A. Rossello

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Discovery of a new selective inhibitor of A Disintegrin And Metalloprotease 10 (ADAM-10) able to reduce the shedding of NKG2D ligands in Hodgkin's lymphoma cell models.

Armando Rossello, Tiziano Tuccinardi, Elisa Nuti, 2016, European journal of medicinal chemistry.

X-ray crystal structure and activity of fluorenyl-based compounds as transthyretin fibrillogenesis inhibitors

E. Stura, S. Nencetti, L. Ciccone, 2016, Journal of enzyme inhibition and medicinal chemistry.

N-O-Isopropyl Sulfonamido-Based Hydroxamates as Matrix Metalloproteinase Inhibitors: Hit Selection and in Vivo Antiangiogenic Activity.

Armando Rossello, Tiziano Tuccinardi, Adriano Martinelli, 2015, Journal of medicinal chemistry.

Matrix metalloproteinase inhibitors: new challenges in the era of post broad-spectrum inhibitors.

T. Tuccinardi, E. Nuti, A. Rossello, 2007, Current pharmaceutical design.

Targeting ADAM17 Sheddase Activity in Cancer.

S. Ferrini, E. Nuti, A. Rossello, 2016, Current drug targets.

N-O-isopropyl sulfonamido-based hydroxamates: design, synthesis and biological evaluation of selective matrix metalloproteinase-13 inhibitors as potential therapeutic agents for osteoarthritis.

E. Novellino, Valeria La Pietra, L. Marinelli, 2009, Journal of medicinal chemistry.

Different Subcellular Localization of ALCAM Molecules in Neuroblastoma: Association with Relapse

S. Ferrini, C. Gambini, A. Rossello, 2010, Cellular oncology : the official journal of the International Society for Cellular Oncology.

Multicomponent mixtures for cryoprotection and ligand solubilization☆

E. Stura, L. Vera, L. Ciccone, 2015, Biotechnology reports.

The ALCAM Shedding by the Metalloprotease ADAM17/TACE Is Involved in Motility of Ovarian Carcinoma Cells

S. Canevari, S. Ferrini, A. Rossello, 2007, Molecular Cancer Research.

Hop derived flavonoid xanthohumol inhibits endothelial cell functions via AMPK activation

D. Noonan, A. Albini, A. Rossello, 2016, Oncotarget.

Design, synthesis, biological evaluation, and NMR studies of a new series of arylsulfones as selective and potent matrix metalloproteinase-12 inhibitors.

Armando Rossello, Tiziano Tuccinardi, Adriano Martinelli, 2009, Journal of medicinal chemistry.

Ionic liquid-promoted green synthesis of biologically relevant diaryl thioethers

E. Nuti, A. Rossello, C. Chiappe, 2020 .

Study of the binding interaction between fluorinated matrix metalloproteinase inhibitors and Human Serum Albumin.

C. Geraldes, A. Maiocchi, T. Tuccinardi, 2014, European journal of medicinal chemistry.

Synthesis and preliminary evaluation in tumor bearing mice of new (18)F-labeled arylsulfone matrix metalloproteinase inhibitors as tracers for positron emission tomography.

L. Tei, A. Maiocchi, A. Quattrini, 2013, Journal of medicinal chemistry.

Arylsulfonamide inhibitors of aggrecanases as potential therapeutic agents for osteoarthritis: synthesis and biological evaluation.

E. Novellino, F. Da Settimo, S. Taliani, 2013, European journal of medicinal chemistry.

Immobilization of matrix metalloproteinase 8 (MMP-8) for online drug screening.

E. Nuti, A. Rossello, A. Petri, 2011, Journal of chromatography. B, Analytical technologies in the biomedical and life sciences.

Synthesis and biological evaluation in U87MG glioma cells of (ethynylthiophene)sulfonamido-based hydroxamates as matrix metalloproteinase inhibitors.

E. Novellino, F. Da Settimo, C. Martini, 2011, European journal of medicinal chemistry.

Synthesis and antimicrobial activity of 7 beta-(S)- and 7 beta-[(R)-3-(methyleneaminoxy)-2-methylpropionamido]substituted cephalosporanic acid derivatives.

E. Orlandini, A. Rossello, M. Macchia, 1996, Farmaco.

Discovery of 1,1'-Biphenyl-4-sulfonamides as a New Class of Potent and Selective Carbonic Anhydrase XIV Inhibitors.

C. Supuran, A. Coluccia, D. Vullo, 2015, Journal of medicinal chemistry.

Synthesis and in vitro Evaluation of ADAM10 and ADAM17 Highly Selective Bioimaging Probes

Caterina Camodeca, E. Nuti, A. Poggi, 2018, ChemMedChem.

Carbonic anhydrase and matrix metalloproteinase inhibitors. Inhibition of human tumor-associated isozymes IX and cytosolic isozyme I and II with sulfonylated hydroxamates.

C. Supuran, A. Scozzafava, A. Innocenti, 2007, Bioorganic & medicinal chemistry.

Synthesis and α2-adrenergic activity of 2-[(methyleneamino)oxy]-N-(guanidino)ethaneimines. A bioisosteric replacement of the aryl of guanabenz-type benzylideneaminoguanidine α2-agonists with the [(methyleneamino)oxy]methyl moiety (MAOMM)

A. Rossello, M. Macchia, A. Balsamo, 1996 .

Synthesis and antiviral activity of dihydroxycyclohexyl pyrimidine and purine carbocyclic nucleosides

L. Drago, M. Gismondo, M. Cisternino, 1995 .

The metalloprotease ADAM10 (a disintegrin and metalloprotease 10) undergoes rapid, postlysis autocatalytic degradation

C. Blobel, P. Noy, M. Tomlinson, 2018, FASEB journal : official publication of the Federation of American Societies for Experimental Biology.

Vascular ADAM17 as a Novel Therapeutic Target in Mediating Cardiovascular Hypertrophy and Perivascular Fibrosis Induced by Angiotensin II

H. Kwok, S. Eguchi, E. Nuti, 2016, Hypertension.

Development of a fluorogenic ADAMTS-7 substrate

A. Snijders, Steven A. Howell, T. Tuccinardi, 2021, Journal of enzyme inhibition and medicinal chemistry.

Chiral 2-(3′-(5′-p-chlorophenyl)isoxazolidinyl)ethanolamines as conformationally restrained analogs of methyloxyiminomethyl (MOIM) β-adrenergic antagonists: synthesis, configuration and β-adrenergic properties*

P. Cozzini, M. Breschi, G. Chiellini, 1996 .

Editorial: ADAM10 in Cancer Immunology and Autoimmunity: More Than a Simple Biochemical Scissor

A. Poggi, M. Zocchi, A. Rossello, 2020, Frontiers in Immunology.

Inhibitors of ADAM10 reduce Hodgkin lymphoma cell growth in 3D microenvironments and enhance brentuximab-vedotin effect

M. Gobbi, Roberta Pece, Caterina Camodeca, 2021, Haematologica.

ADAM10 new selective inhibitors reduce NKG2D ligand release sensitizing Hodgkin lymphoma cells to NKG2D-mediated killing

Caterina Camodeca, E. Nuti, A. Poggi, 2015, Oncoimmunology.

The metalloproteinase ADAM10 requires its activity to sustain surface expression

M. Tomlinson, E. Nuti, A. Rossello, 2020, Cellular and Molecular Life Sciences.

Exosite inhibition of ADAMTS-5 by a glycoconjugated arylsulfonamide

T. Tuccinardi, L. Ciccone, E. Nuti, 2021, Scientific reports.

Exosite inhibition of A Disintegrin And Metalloproteinase with Thrombospondin motif (ADAMTS)-5 by a glycoconjugated arylsulfonamide

T. Tuccinardi, L. Ciccone, E. Nuti, 2020, bioRxiv.

Targeting Aggrecanases for Osteoarthritis Therapy: From Zinc Chelation to Exosite Inhibition

L. Ciccone, E. Nuti, A. Rossello, 2022, Journal of medicinal chemistry.

Synthesis and α-adrenergic and I1-imidazoline activity of 3-phenylpiperidines dimethyl-substituted on the phenyl ring

D. Bylund, G. Giannaccini, A. Lucacchini, 1998 .

Conformationally restrained β-blocking oxime ethers. 2. Synthesis and β-adrenergic properties of diastereoisomeric anti and syn 2-(5′-(3′-aryl-substituted)isoxazolidinyl)-N-alkylethanolamines

C. Martini, M. Breschi, G. Chiellini, 1994 .

A new D₂ dopamine receptor agonist allosterically modulates A(2A) adenosine receptor signalling by interacting with the A(2A)/D₂ receptor heteromer.

M. Trincavelli, C. Martini, C. Lluis, 2012, Cellular signalling.

New NO-releasing pharmacodynamic hybrids of losartan and its active metabolite: design, synthesis, and biopharmacological properties.

M. Breschi, S. Rapposelli, A. Rossello, 2006, Journal of medicinal chemistry.

Inhibition of matrix degrading enzymes and invasion in rat glioblastoma (C6) Cells

C. Martini, E. Nuti, A. Rossello, 2009 .

Hepatitis C virus-induced NK cell activation causes metzincin-mediated CD16 cleavage and impaired antibody-dependent cytotoxicity.

S. Ludovisi, M. Mondelli, E. Nuti, 2017, Journal of hepatology.

The metalloproteinase ADAM10 requires its activity to sustain surface expression

M. Tomlinson, E. Nuti, A. Rossello, 2020, Cellular and Molecular Life Sciences.

Inhibition of metalloproteinases derived from tumours: new insights in the treatment of human glioblastoma

E. Novellino, C. Martini, E. Orlandini, 2010, Neuroscience.

Enantiopure 3-(arylmethylidene)aminoxy-2-methylpropionic acids: synthesis and antiinflammatory properties.

A. Lapucci, S. Rapposelli, S. Nencetti, 2001, European journal of medicinal chemistry.

Identification of a Novel p53 Modulator Endowed with Antitumoural and Antibacterial Activity through a Scaffold Repurposing Approach

C. Martini, A. Carotenuto, Valeria La Pietra, 2022, Pharmaceuticals.

Antioxidant Quercetin 3-O-Glycosylated Plant Flavonols Contribute to Transthyretin Stabilization

C. Fruchart-Gaillard, S. Nencetti, L. Ciccone, 2022, Crystals.

New N-arylsulfonyl-N-alkoxyaminoacetohydroxamic acids as selective inhibitors of gelatinase A (MMP-2).

A. Albini, S. Rapposelli, E. Orlandini, 2004, Bioorganic & medicinal chemistry.

New bifunctional metalloproteinase inhibitors: an integrated approach towards biological improvements and cancer therapy.

E. Nuti, A. Rossello, S. Marques, 2013, Journal of Inorganic Biochemistry.

Synthesis and antimicrobial activity of new 7 beta-(benzo[a]dihydrocarbazolyloxyacetyl)-substituted cephalosporins.

S. Rapposelli, E. Orlandini, E. Nuti, 2004, Il Farmaco.

Synthesis of heteroaromatic analogues of (2-aryl-1-cyclopentenyl-1-alkylidene)-(arylmethyloxy)amine COX-2 inhibitors: effects on the inhibitory activity of the replacement of the cyclopentene central core with pyrazole, thiophene or isoxazole ring.

F. Mancini, S. Rapposelli, M. Pinza, 2003, European journal of medicinal chemistry.

Synthesis and Antimicrobial Activity of New 7β-(Benzo[a]dihydrocarbazolyloxyacetyl)-Substituted Cephalosporins.

S. Rapposelli, E. Orlandini, E. Nuti, 2005 .

New N-substituted 7-aminocephalosporanic acid derivatives as potential agents against Streptococcus pneumoniae. Synthesis and in vitro activity.

A. Rossello, E. Di Modugno, M. Macchia, 1999, Bioorganic & medicinal chemistry letters.

Synthesis and antimicrobial activity of benzo[a]dihydrocarbazole and benzotetrahydrocyclohept[1,2-b]indole derivatives.

S. Nencetti, A. Rossello, C. Manera, 1996, Farmaco.

Identification of novel molecular scaffolds for the design of MMP-13 inhibitors: a first round of lead optimization.

E. Novellino, F. Da Settimo, S. Taliani, 2012, European journal of medicinal chemistry.

Structural insights on carbonic anhydrase inhibitory action, isoform selectivity, and potency of sulfonamides and coumarins incorporating arylsulfonylureido groups.

C. Supuran, A. Scozzafava, E. Masini, 2014, Journal of medicinal chemistry.

Combining the tail and the ring approaches for obtaining potent and isoform-selective carbonic anhydrase inhibitors: solution and X-ray crystallographic studies.

C. Supuran, A. Scozzafava, M. Ferraroni, 2014, Bioorganic & medicinal chemistry.

Methotrexate γ-hydroxamate derivatives as potential dual target antitumor drugs

S. Krupenko, E. Nuti, A. Rossello, 2007 .

Synthesis and cycloxygenase inhibitory properties of new naphthalene-methylsulfonamido, naphthalene-methylsulfonyl and tetrahydronaphthalen-methylsulfonamido compounds

S. Nencetti, L. Ciccone, E. Orlandini, 2015, Journal of enzyme inhibition and medicinal chemistry.

Synthesis and antimicrobial properties of cephalosporin derivatives substituted on the C(7) nitrogen with arylmethyloxyimino or arylmethyloxyamino alkanoyl groups.

S. Nencetti, E. Orlandini, A. Rossello, 1999, Farmaco.

Synthesis and β-adrenergic properties of tetrahydronaphthalene analogs of dichloroisoproterenol

C. Martini, M. Breschi, G. Giannaccini, 1993 .

Synthesis, SAR, and Biological Evaluation of α‐Sulfonylphosphonic Acids as Selective Matrix Metalloproteinase Inhibitors

Cristina Campestre, Mariangela Agamennone, E. Nuti, 2009, ChemMedChem.

Synthesis and Aldose Reductase Inhibitory Activity of Some N-(Aroyl)-N- (arylalkyloxy)-glycines and -β-Alanines.

S. Nencetti, E. Orlandini, A. Rossello, 1996 .

Role of the benzylic hydroxyl group of adrenergic catecholamines in eliciting α-adrenergic activity. Synthesis and α1- and α2-adrenergic activity of 3-phenyl-3-piperidinols and their desoxy analogs*

S. Nencetti, E. Orlandini, A. Rossello, 1995 .

X-ray analysis, theoretical studies and α-adrenergic biopharmacological properties of 1-(2,5-dimethoxyphenyl)-2-aminoethanol and its morpholine analogue

P. Cozzini, G. Giannaccini, A. Martinelli, 1992 .

Synthesis, inhibitory activity towards human leukocyte elastase and molecular modelling studies of 1-carbamoyl-4-methyleneaminoxyazetidinones.

A. Martinelli, E. Orlandini, A. Rossello, 2000, European journal of medicinal chemistry.

An overview of carbohydrate-based carbonic anhydrase inhibitors

E. Nuti, A. Rossello, Doretta Cuffaro, 2020, Journal of enzyme inhibition and medicinal chemistry.

Tricyclic sulfonamides incorporating benzothiopyrano[4,3-c]pyrazole and pyridothiopyrano[4,3-c]pyrazole effectively inhibit α- and β-carbonic anhydrase: X-ray crystallography and solution investigations on 15 isoforms.

F. Da Settimo, S. Taliani, C. La Motta, 2012, Journal of medicinal chemistry.

Developments in Carbohydrate-Based Metzincin Inhibitors

E. Nuti, A. Rossello, F. D’Andrea, 2020, Pharmaceuticals.

Targeting Different Transthyretin Binding Sites with Unusual Natural Compounds

A. Martinelli, S. Nencetti, L. Ciccone, 2016, ChemMedChem.

alpha-Biphenylsulfonylamino 2-methylpropyl phosphonates: enantioselective synthesis and selective inhibition of MMPs.

Cristina Campestre, Mariangela Agamennone, E. Nuti, 2007, Bioorganic & medicinal chemistry.

Design and Synthesis of Ionic Liquid‐Based Matrix Metalloproteinase Inhibitors (MMPIs): A Simple Approach to Increase Hydrophilicity and to Develop MMPI‐Coated Gold Nanoparticles

V. Cappello, M. Gemmi, S. Nencetti, 2019, ChemMedChem.

Amber force field implementation, molecular modelling study, synthesis and MMP-1/MMP-2 inhibition profile of (R)- and (S)-N-hydroxy-2-(N-isopropoxybiphenyl-4-ylsulfonamido)-3-methylbutanamides.

Armando Rossello, Tiziano Tuccinardi, Adriano Martinelli, 2006, Bioorganic & medicinal chemistry.

N-i-Propoxy-N-biphenylsulfonylaminobutylhydroxamic acids as potent and selective inhibitors of MMP-2 and MT1-MMP.

Armando Rossello, Marco Macchia, Federica Balzano, 2005, Bioorganic & medicinal chemistry letters.

Synthesis, antifungal activity, and molecular modeling studies of new inverted oxime ethers of oxiconazole.

A. Lapucci, S. Rapposelli, A. Martinelli, 2002, Journal of medicinal chemistry.

Design, synthesis and molecular modeling study of iminodiacetyl monohydroxamic acid derivatives as MMP inhibitors.

T. Tuccinardi, A. Rossello, S. Marques, 2006, Bioorganic & medicinal chemistry.

Synthesis and β-adrenergic properties of (E)-N-[3-(alkylamino)-2-hydroxypropylidene](methyloxy)amines substituted with an aromatic group on their [(methyloxy)imino]methyl moiety (MOIMM): an investigation into the biopharmacological effects of an aryl substitution in the class of MOIM β-blocking drug

C. Martini, M. Breschi, G. Chiellini, 1995 .

Synthesis and antiangiogenic activity study of new hop chalcone Xanthohumol analogues.

Armando Rossello, Elisabetta Orlandini, Elisa Nuti, 2017, European journal of medicinal chemistry.

Tafamidis (Vyndaqel): A Light for FAP Patients

S. Nencetti, E. Orlandini, A. Rossello, 2013, ChemMedChem.

MMP‐8 Is Critical for Dexamethasone Therapy in Alkali‐Burned Corneas Under Dry Eye Conditions

Changjun Wang, Caterina Camodeca, E. Nuti, 2016, Journal of cellular physiology.

G. Vozzi, S. Nencetti, E. Orlandini, 2019, Current drug targets.

Sugar‐Based Arylsulfonamide Carboxylates as Selective and Water‐Soluble Matrix Metalloproteinase‐12 Inhibitors

Armando Rossello, Marina Fabbi, Lidia Ciccone, 2016, ChemMedChem.

The [(methyloxy)imino]methyl moiety (MOIMM) in the design of a new type of β-adrenergic blocking agent

Armando Rossello, Adriano Martinelli, Marco Macchia, 1999 .

Conformationally restrained β-blocking oxime ethers: synthesis and β-adrenergic properties of diastereoisomeric anti and syn 2-(5′-isoxazolidinyl)-ethanolamines

C. Martini, M. Breschi, G. Giannaccini, 1992 .

Synthesis and β-Adrenergic Properties of (Z)-N-[3-(Alkylamino)-2-hydroxypropylidene](aryl-methyloxy)amines: Effects of the Configuration Around the Methyloxyiminomethyl (MOIM) Double Bond on the Biopharmacological Properties of MOIM-type β-Blocking Agents

A. Lapucci, M. Breschi, G. Chiellini, 1998 .

Conformationally restrained β-blocking oxime ethers. 3. Synthesis and β-adrenergic antagonistic activity of diastereomeric anti and syn 2-(5′-(3′-methyl)isoxazolidinyl)-N-alkylethanolamines*

M. Breschi, S. Nencetti, A. Rossello, 1996 .

Strategies to Target ADAM17 in Disease: From Its Discovery to the iRhom Revolution

E. Nuti, A. Rossello, S. D. Scilabra, 2021, Molecules.

Activation of carbonic anhydrases from human brain by amino alcohol oxime ethers: towards human carbonic anhydrase VII selective activators

C. Supuran, S. Nencetti, L. Ciccone, 2020, Journal of enzyme inhibition and medicinal chemistry.

Synthesis, binding affinity, and transcriptional activity of hydroxy- and methoxy-Substituted 3,4-Diarylsalicylaldoximes on estrogen receptors α and β

J. Katzenellenbogen, K. Carlson, S. Rapposelli, 2003 .

ADAM10 correlates with uveal melanoma metastasis and promotes in vitro invasion

P. Queirolo, M. Gualco, S. Ferrini, 2014, Pigment cell & melanoma research.

Dual inhibitors of matrix metalloproteinases and carbonic anhydrases: iminodiacetyl-based hydroxamate-benzenesulfonamide conjugates.

C. Supuran, T. Tuccinardi, A. Martinelli, 2008, Journal of medicinal chemistry.

Identification of histone deacetylase inhibitors with (arylidene)aminoxy scaffold active in uveal melanoma cell lines

G. Marshall, F. Ballante, S. Nencetti, 2020, Journal of enzyme inhibition and medicinal chemistry.

Metalloprotease inhibitor profiles of human ADAM8 in vitro and in cell-based assays

T. Tuccinardi, E. Nuti, A. Rossello, 2019, Biological chemistry.

Identification of Broad-Spectrum MMP Inhibitors by Virtual Screening

M. Mulero, S. Garcia-Vallvé, G. Pujadas, 2021, Molecules.

Kinetic characterization of 4,4′-biphenylsulfonamides as selective non-zinc binding MMP inhibitors

C. Supuran, R. Silvestri, G. La Regina, 2015, Journal of enzyme inhibition and medicinal chemistry.

Biphenyl Sulfonylamino Methyl Bisphosphonic Acids as Inhibitors of Matrix Metalloproteinases and Bone Resorption

P. Campiglia, Cristina Campestre, R. Faccio, 2011, ChemMedChem.

Omega-3 PUFAs as a Dietary Supplement in Senile Systemic Amyloidosis

S. Nencetti, L. Ciccone, E. Orlandini, 2023, Nutrients.

Novel folate-hydroxamate based antimetabolites: synthesis and biological evaluation.

S. Krupenko, T. Tuccinardi, A. Martinelli, 2011, Medicinal chemistry (Shariqah (United Arab Emirates)).

Monoaryl derivatives as transthyretin fibril formation inhibitors: Design, synthesis, biological evaluation and structural analysis.

W. Shepard, S. Nencetti, L. Ciccone, 2020, Bioorganic & medicinal chemistry.

Synthesis and structural analysis of halogen substituted fibril formation inhibitors of Human Transthyretin (TTR)

E. Stura, S. Nencetti, L. Ciccone, 2016, Journal of enzyme inhibition and medicinal chemistry.

3‐[(aryl)(4‐fluorobenzyloxy)methyl]piperidine derivatives: high‐affinity ligands for the serotonin transporter

G. Demontis, A. Lapucci, S. Nencetti, 2007, The Journal of pharmacy and pharmacology.

Deficient Natural Killer Cell NKp30‐Mediated Function and Altered NCR3 Splice Variants in Hepatocellular Carcinoma

C. Porta, F. Negro, S. Clément, 2019, Hepatology.

ADAM metalloproteinases as potential drug targets.

Caterina Camodeca, E. Nuti, A. Rossello, 2019, Current medicinal chemistry.

Activated leukocyte cell adhesion molecule soluble form: a potential biomarker of epithelial ovarian cancer is increased in type II tumors

S. Canevari, S. Ferrini, A. Rossello, 2013, International journal of cancer.

Specific ADAM10 inhibitors localize in exosome-like vesicles released by Hodgkin lymphoma and stromal cells and prevent sheddase activity carried to bystander cells

Caterina Camodeca, E. Nuti, A. Poggi, 2017, Oncoimmunology.

Crystallization of bi-functional ligand protein complexes.

Armando Rossello, Elisa Nuti, E. Stura, 2013, Journal of structural biology.

Matrix metalloproteinase-12 inhibitors: synthesis, structure-activity relationships and intestinal absorption of novel sugar-based biphenylsulfonamide carboxylates.

E. Orlandini, Caterina Camodeca, E. Nuti, 2018, Bioorganic & medicinal chemistry.

Bivalent Inhibitor with Selectivity for Trimeric MMP-9 Amplifies Neutrophil Chemotaxis and Enables Functional Studies on MMP-9 Proteoforms

G. Opdenakker, Caterina Camodeca, E. Nuti, 2020, Cells.

Synthesis and HIV-1 inhibitory properties of new tetrahydrobenzoquinazolinedione and tetrahydrobenzocycloheptenuracil derivatives and of their thioxo analogues.

O. Turriziani, G. Antonelli, A. Martinelli, 1999, Farmaco.

Design, synthesis and biological evaluation of bifunctional inhibitors of membrane type 1 matrix metalloproteinase (MT1-MMP).

N. Ito, Y. Itoh, T. Tuccinardi, 2019, Bioorganic & medicinal chemistry.

Development of a receptor-based 3D-QSAR study for the analysis of MMP2, MMP3, and MMP9 inhibitors.

T. Tuccinardi, A. Martinelli, E. Nuti, 2008, Bioorganic & medicinal chemistry.

Peptidyl 3-substituted 1-hydroxyureas as isosteric analogues of succinylhydroxamate MMP inhibitors.

Cristina Campestre, Mariangela Agamennone, E. Nuti, 2008, European journal of medicinal chemistry.

Analysis of Human Carbonic Anhydrase II: Docking Reliability and Receptor-Based 3D-QSAR Study

Claudiu T. Supuran, Armando Rossello, Tiziano Tuccinardi, 2007, J. Chem. Inf. Model..

Selective arylsulfonamide inhibitors of ADAM-17: hit optimization and activity in ovarian cancer cell models.

E. Novellino, S. Ferrini, Valeria La Pietra, 2013, Journal of medicinal chemistry.

Matrix metalloproteinase inhibitors prevent the release and proteolytic activity of monocyte/macrophage-derived microparticles

S. Fogli, Caterina Camodeca, E. Nuti, 2019, Pharmacological reports : PR.

Synthesis, experimental evaluation and molecular modelling of hydroxamate derivatives as zinc metalloproteinase inhibitors.

I. Sylte, Stian Sjøli, O. A. Adekoya, 2016, European journal of medicinal chemistry.

In Vivo Imaging of Matrix Metalloproteinase 12 and Matrix Metalloproteinase 13 Activities in the Mouse Model of Collagen‐Induced Arthritis

V. Dive, M. Meldal, George Bou-Gharios, 2014, Arthritis & rheumatology.

N-O-isopropyl sulfonamido-based hydroxamates: kinetic characterisation of a series of MMP-12/MMP-13 dual target inhibitors.

E. Novellino, Valeria La Pietra, L. Marinelli, 2012, Biochemical pharmacology.

Novel 1-hydroxypiperazine-2,6-diones as new leads in the inhibition of metalloproteinases.

Armando Rossello, Tiziano Tuccinardi, Adriano Martinelli, 2011, Journal of medicinal chemistry.

N-(Aroyl)-N-(arylmethyloxy)-α-alanines: Selective inhibitors of aldose reductase.

C. La Motta, S. Sartini, S. Nencetti, 2017, Bioorganic & medicinal chemistry.

Development of Thioaryl-Based Matrix Metalloproteinase-12 Inhibitors with Alternative Zinc-Binding Groups: Synthesis, Potentiometric, NMR, and Crystallographic Studies.

E. Stura, L. Vera, V. Dive, 2018, Journal of medicinal chemistry.

Synthesis and inhibitory activity towards human leukocyte elastase of new 7α-methoxy and 7α-chloro (2-acyloxymethyl) cephem derivatives

A. Lapucci, S. Rapposelli, E. Orlandini, 2001 .

Bacterial Zinc Metalloenzyme Inhibitors: Recent Advances and Future Perspectives

E. Nuti, A. Rossello, Riccardo Di Leo, 2023, Molecules.

Crystal and molecular structure of tetrabutylammonium (3lS, 4S)-3-phenylacetamido-4-methyl-2-oxoazetidine-1-sulfonate

A. Rossello, A. Balsamo, F. Macchia, 1991 .

Synthesis and antimicrobial properties of new cepham and penam derivatives with the carboxylic group in the wrong β-configuration

S. Nencetti, E. Orlandini, A. Rossello, 1989 .

Novel Transthyretin Amyloid Fibril Formation Inhibitors: Synthesis, Biological Evaluation, and X-Ray Structural Analysis

Joel S. Freundlich, J. Sacchettini, A. Lapucci, 2009, PloS one.

New isoxazolidinyl-based N-alkylethanolamines as new activators of human brain carbonic anhydrases

C. Supuran, L. Ciccone, E. Nuti, 2023, Journal of enzyme inhibition and medicinal chemistry.

Identification of N-Acyl Hydrazones as New Non-Zinc-Binding MMP-13 Inhibitors by Structure-Based Virtual Screening Studies and Chemical Optimization

G. Pujadas, S. Nencetti, E. Nuti, 2023, International journal of molecular sciences.

A new development of matrix metalloproteinase inhibitors: twin hydroxamic acids as potent inhibitors of MMPs.

S. Rapposelli, T. Tuccinardi, E. Orlandini, 2005, Bioorganic & medicinal chemistry letters.

Synthesis and prostaglandin synthase inhibitory activity of new aromatic O-alkyloxime ethers substituted with methylsulfonamido or methylsulfonyl groups on their aliphatic portion.

F. Mancini, S. Rapposelli, M. Pinza, 2003, Farmaco.

Pomegranate: A Source of Multifunctional Bioactive Compounds Potentially Beneficial in Alzheimer’s Disease

S. Nencetti, L. Ciccone, E. Orlandini, 2023, Pharmaceuticals.

Inhibition of pseudolysin and thermolysin by hydroxamate-based MMP inhibitors.

I. Sylte, Stian Sjøli, O. A. Adekoya, 2015, European journal of medicinal chemistry.

3-(4-iodomethyl-2-oxo-1-azetidinyl)propynoic acidt-butyl ester: a new β-lactam derivative, synthesis of an ynamide by reaction of 4-iodomethylazetidin-2-one with the t-butyl ester of propiolic acid in the presence of copper(i)

A. Rossello, A. Balsamo, F. Macchia, 1985 .

Bifunctional Inhibitors as a New Tool To Reduce Cancer Cell Invasion by Impairing MMP-9 Homodimerization.

C. Martini, E. Stura, L. Vera, 2017, ACS medicinal chemistry letters.

Amino Acid Derivatives as New Zinc Binding Groups for the Design of Selective Matrix Metalloproteinase Inhibitors

E. Novellino, A. Di Pizio, A. Bertamino, 2013, Journal of amino acids.

Screening Using Polymorphs for the Crystallization of Protein–Ligand Complexes

E. Stura, L. Vera, V. Dive, 2013 .

Pomegranate: A Source of Multifunctional Bioactive Compounds Potentially Beneficial in Alzheimer's Disease.

S. Nencetti, L. Ciccone, E. Orlandini, 2023, Pharmaceuticals.

Potent arylsulfonamide inhibitors of tumor necrosis factor-alpha converting enzyme able to reduce activated leukocyte cell adhesion molecule shedding in cancer cell models.

E. Novellino, S. Ferrini, V. Limongelli, 2010, Journal of medicinal chemistry.

New Hybrid Compounds Incorporating Natural Products as Multifunctional Agents against Alzheimer’s Disease

C. La Motta, S. Nencetti, L. Ciccone, 2023, Pharmaceutics.

Tafamidis (Vyndaqel): A Light for FAP Patients

S. Nencetti, E. Orlandini, A. Rossello, 2013, ChemMedChem.

F. Da Settimo, S. Taliani, C. La Motta, 2012, Journal of medicinal chemistry.