S. Gerhardt

发表

Seeding for sirtuins: microseed matrix seeding to obtain crystals of human Sirt3 and Sirt2 suitable for soaking

Tobias Rumpf, M. Jung, S. Gerhardt, 2015, Acta crystallographica. Section F, Structural biology communications.

4-Acyl pyrroles: mimicking acetylated lysines in histone code reading.

R. Schüle, S. Günther, M. Jung, 2013, Angewandte Chemie.

Dipeptidyl nitrile inhibitors of Cathepsin L.

S. Steinbacher, Matthew Grist, M. Augustin, 2009, Bioorganic & medicinal chemistry letters.

Action at a distance for glp repressor control of glpTQ transcription in Escherichia coli K‐12

T. Larson, S. Gerhardt, B. Yang, 1997, Molecular microbiology.

Crystal structures of human ADAMTS-1 reveal a conserved catalytic domain and a disintegrin-like domain with a fold homologous to cysteine-rich domains.

A. Parker, D. Hargreaves, R. Pauptit, 2007, Journal of molecular biology.

Structure of IL-17A in complex with a potent, fully human neutralizing antibody.

S. Tuske, Y. Hamuro, D. Hargreaves, 2009, Journal of molecular biology.

A mechanism to prevent production of reactive oxygen species by Escherichia coli respiratory complex I

T. Friedrich, S. Gerhardt, O. Einsle, 2019, Nature Communications.

Variant G129D of NuoEF from Aquifex aeolicus bound to NAD+

T. Friedrich, S. Gerhardt, O. Einsle, 2019 .

Structural basis of O-methylation of (2-heptyl-)1-hydroxyquinolin-4(1H)-one and related compounds by the heterocyclic toxin methyltransferase Rv0560c of Mycobacterium tuberculosis.

S. Fetzner, S. Gerhardt, O. Einsle, 2021, Journal of structural biology.

Structure-Based Development of an Affinity Probe for Sirtuin 2.

J. Ovádi, Tobias Rumpf, W. Sippl, 2016, Angewandte Chemie.

Crystal structure of Cdc11, a septin subunit from Saccharomyces cerevisiae.

N. Johnsson, S. Gerhardt, O. Einsle, 2016, Journal of structural biology.

Direct Reductive Amination of Ketones: Structure and Activity of S‐Selective Imine Reductases from Streptomyces

S. Gerhardt, O. Einsle, Michael Müller, 2014 .

Functional and structural characterisation of a bacterial O‐methyltransferase and factors determining regioselectivity

M. Richter, S. Gerhardt, O. Einsle, 2017, FEBS letters.

The structural basis of riboflavin binding to Schizosaccharomyces pombe 6,7-dimethyl-8-ribityllumazine synthase.

S. Steinbacher, R. Huber, A. Bacher, 2002, Journal of molecular biology.

Crystal structure of VnfH, the iron protein component of vanadium nitrogenase

S. Gerhardt, O. Einsle, D. Sippel, 2018, JBIC Journal of Biological Inorganic Chemistry.

Crystal structure of VnfH, the iron protein component of vanadium nitrogenase

S. Gerhardt, O. Einsle, D. Sippel, 2018, JBIC Journal of Biological Inorganic Chemistry.

Design of selective Cathepsin inhibitors.

S. Steinbacher, M. Augustin, Galith Karoutchi, 2009, Bioorganic & medicinal chemistry letters.

Identification and optimisation of 3,3-dimethyl-azetidin-2-ones as potent and selective inhibitors of 11β-hydroxysteroid dehydrogenase type 1 (11β-HSD1)

S. Steinbacher, M. Augustin, D. Ogg, 2014 .

Aminothiazoles as Potent and Selective Sirt2 Inhibitors: A Structure-Activity Relationship Study.

J. Ovádi, Tobias Rumpf, J. Olah, 2016, Journal of medicinal chemistry.

Biocatalytic Properties and Structural Analysis of Phloroglucinol Reductases.

Michael Müller, S. Gerhardt, O. Einsle, 2016, Angewandte Chemie.

Structure and Properties of an Engineered Transketolase from Maize1

Robert Huber, R. Huber, A. Bacher, 2003, Plant Physiology.

Improving coiled coil stability while maintaining specificity by a bacterial hitchhiker selection system.

K. Müller, K. Arndt, S. Gerhardt, 2014, Journal of structural biology.

A combined spectroscopic and crystallographic approach to probing drug-human serum albumin interactions.

David Buttar, S. Steinbacher, A. Plowright, 2010, Bioorganic & medicinal chemistry.

Substrate recognition and mechanism revealed by ligand-bound polyphosphate kinase 2 structures

P. Roach, S. Gerhardt, O. Einsle, 2018, Proceedings of the National Academy of Sciences.

Assembly of methylated KDM1A and CHD1 drives androgen receptor–dependent transcription and translocation

M. Schleicher, R. Schüle, S. Perner, 2016, Nature Structural &Molecular Biology.

Structure and Properties of an Engineered Transketolase from Maize 1 Structure of Transketolase from Maize

R. Huber, A. Bacher, G. Auerbach, 2003 .

Structure and Properties of an Engineered Transketolase from Maize 1

R. Huber, A. Bacher, W. Martin, 2003 .

Engineering a high-affinity anti-IL-15 antibody: crystal structure reveals an α-helix in VH CDR3 as key component of paratope.

D. Hargreaves, R. Pauptit, Malcolm A. Anderson, 2011, Journal of molecular biology.

Selective non zinc binding inhibitors of MMP13.

D. Hargreaves, P. Macfaul, Galith Karoutchi, 2011, Bioorganic & medicinal chemistry letters.

Prevention of MKK6-dependent activation by binding to p38alpha MAP kinase.

Jon Read, Alexander L Breeze, Richard A Norman, 2005, Biochemistry.

Gramicidin S synthetase. Temperature dependence and thermodynamic parameters of substrate amino acid activation reactions.

S. Gerhardt, J. Vater, A. Gadow, 1985, Biochemistry.

A Conformational Switch Triggers Nitrogenase Protection from Oxygen Damage by Shethna Protein II (FeSII).

S. Gerhardt, O. Einsle, M. Rohde, 2016, Journal of the American Chemical Society.

Structural basis of the action of glucosyltransferase Lgt1 from Legionella pneumophila.

K. Aktories, Juan Du, S. Gerhardt, 2010, Journal of molecular biology.

Selective Sirt2 inhibition by ligand-induced rearrangement of the active site

Wolfgang Sippl, Judit Ovádi, Manfred Jung, 2015, Nature Communications.

Novel acidic 11β-hydroxysteroid dehydrogenase type 1 (11β-HSD1) inhibitor with reduced acyl glucuronide liability: the discovery of 4-[4-(2-adamantylcarbamoyl)-5-tert-butyl-pyrazol-1-yl]benzoic acid (AZD8329).

Martin J Packer, Nidhal Selmi, Andrew Stocker, 2012, Journal of medicinal chemistry.

The discovery of N-cyclopropyl-4-methyl-3-[6-(4-methylpiperazin-1-yl)-4-oxoquinazolin-3(4H)-yl]benzamide (AZD6703), a clinical p38α MAP kinase inhibitor for the treatment of inflammatory diseases.

R. Pauptit, S. Gerhardt, D. Brown, 2012, Bioorganic & medicinal chemistry letters.

4-Acyl Pyrrole Derivatives Yield Novel Vectors for Designing Inhibitors of the Acetyl-Lysine Recognition Site of BRD4(1).

Stefan Günther, Xavier Lucas, S. Günther, 2016, Journal of medicinal chemistry.

Structural Basis for Inhibition of ROS‐Producing Respiratory Complex I by NADH‐OH

S. Günther, A. Randazzo, T. Friedrich, 2021, Angewandte Chemie.

Crystal Structure of an Archaeal Pentameric Riboflavin Synthase in Complex with a Substrate Analog Inhibitor

R. Huber, W. Eisenreich, A. Bacher, 2006, Journal of Biological Chemistry.

Riboflavin synthase of Schizosaccharomyces pombe. Protein dynamics revealed by 19F NMR protein perturbation experiments

S. Steinbacher, R. Huber, W. Eisenreich, 2003, BMC Biochemistry.

Incorporation of an amide into 5-phosphonoalkyl-6-D-ribitylaminopyrimidinedione lumazine synthase inhibitors results in an unexpected reversal of selectivity for riboflavin synthase vs lumazine synthase.

R. Huber, A. Bacher, M. Fischer, 2002, The Journal of organic chemistry.

Studies on the reaction mechanism of riboflavin synthase: X-ray crystal structure of a complex with 6-carboxyethyl-7-oxo-8-ribityllumazine.

S. Steinbacher, R. Huber, W. Eisenreich, 2002, Structure.

Design, synthesis, and evaluation of 6-carboxyalkyl and 6-phosphonoxyalkyl derivatives of 7-oxo-8-ribitylaminolumazines as inhibitors of riboflavin synthase and lumazine synthase.

R. Huber, A. Bacher, M. Fischer, 2002, The Journal of organic chemistry.

Biosynthesis of riboflavin: 6,7-dimethyl-8-ribityllumazine synthase of Schizosaccharomyces pombe.

R. Huber, J. Changeux, A. Bacher, 2002, European journal of biochemistry.

Crystal structure of the type II isopentenyl diphosphate:dimethylallyl diphosphate isomerase from Bacillus subtilis.

S. Steinbacher, R. Huber, W. Eisenreich, 2003, Journal of molecular biology.

Structure of 2C-methyl-d-erythritol-2,4-cyclodiphosphate synthase involved in mevalonate-independent biosynthesis of isoprenoids.

S. Steinbacher, W. Eisenreich, A. Bacher, 2002, Journal of molecular biology.

Beyond the BET Family: Targeting CBP/p300 with 4-Acyl Pyrroles.

S. Günther, M. Jung, S. Gerhardt, 2017, Angewandte Chemie.

Structural and functional characterization of 4-hydroxyphenylpyruvate dioxygenase from the thermoacidophilic archaeon Picrophilus torridus

S. Gerhardt, O. Einsle, Wolfgang Hüttel, 2014, Extremophiles.

Structural characterization of O- and C-glycosylating variants of the landomycin glycosyltransferase LanGT2.

J. Thorson, J. Rohr, Guojun Wang, 2015, Angewandte Chemie.

Discovery of a potent, selective, and orally bioavailable acidic 11β-hydroxysteroid dehydrogenase type 1 (11β-HSD1) inhibitor: discovery of 2-[(3S)-1-[5-(cyclohexylcarbamoyl)-6-propylsulfanylpyridin-2-yl]-3-piperidyl]acetic acid (AZD4017).

Martin J Packer, Nidhal Selmi, David Hargreaves, 2012, Journal of medicinal chemistry.

Structural and functional characterisation of the methionine adenosyltransferase from Thermococcus kodakarensis

M. Richter, S. Gerhardt, O. Einsle, 2013, BMC Structural Biology.

MacA is a second cytochrome c peroxidase of Geobacter sulfurreducens.

S. Elliott, S. Gerhardt, O. Einsle, 2012, Biochemistry.

The design and synthesis of novel N-hydroxyformamide inhibitors of ADAM-TS4 for the treatment of osteoarthritis.

Chris Davies, S. Gerhardt, David J. Milne, 2011, Bioorganic & medicinal chemistry letters.

Matched triplicate design sets in the optimisation of glucokinase activators – maximising medicinal chemistry information content

Michael J. Waring, David Hargreaves, Nathaniel G. Martin, 2013 .

D. Hargreaves, D. Ogg, James S. Scott, 2012, Journal of medicinal chemistry.

4-Acyl pyrroles: mimicking acetylated lysines in histone code reading.

R. Schüle, S. Günther, S. Gerhardt, 2013, Angewandte Chemie.