M. Lamb

发表

"The structure of human GCN2 reveals a parallel, back-to-back kinase dimer with a plastic DFG activation loop motif".

Taiana Maia de Oliveira, V. Korboukh, S. Caswell, 2019, The Biochemical journal.

Performance of 3D-database molecular docking studies into homology models.

E. Bradley, P. Grootenhuis, C. Oshiro, 2004, Journal of medicinal chemistry.

Design of a gene family screening library targeting G-protein coupled receptors.

E. Bradley, P. Grootenhuis, M. Lamb, 2004, Journal of molecular graphics & modelling.

Prediction of binding affinities for TIBO inhibitors of HIV-1 reverse transcriptase using Monte Carlo simulations in a linear response method.

M L Lamb, J Tirado-Rives, W L Jorgensen, 1998, Journal of medicinal chemistry.

Inhibition of Mcl-1 through covalent modification of a noncatalytic lysine side chain.

C. Chuaqui, Nancy Su, Matthew A. Belmonte, 2016, Nature chemical biology.

Discovery of a Series of 7-Azaindoles as Potent and Highly Selective CDK9 Inhibitors for Transient Target Engagement.

A. Ferguson, L. Drew, W. Shao, 2021, Journal of medicinal chemistry.

Structure‐Based Design of Selective Noncovalent CDK12 Inhibitors

Toan B. Nguyen, M. Haddrick, A. Ferguson, 2018, ChemMedChem.

Deconvoluting Kinase Inhibitor Induced Cardiotoxicity

Godfrey L. Smith, Clay W Scott, Jonna C. Stålring, 2017, Toxicological sciences : an official journal of the Society of Toxicology.

Discovery of 2,6-disubstituted pyrazine derivatives as inhibitors of CK2 and PIM kinases.

A. Ferguson, P. Lyne, N. Larsen, 2018, Bioorganic & medicinal chemistry letters.

MYELOID NEOPLASIA AZD1208, a potent and selective pan-Pim kinase inhibitor, demonstrates ef ﬁ cacy in preclinical models of acute myeloid leukemia

L. Platanias, P. Lyne, R. Stone, 2014 .

Pharmacological Inhibition of PARP6 Triggers Multipolar Spindle Formation and Elicits Therapeutic Effects in Breast Cancer.

David A. Scott, Edward W. Tate, J. Dry, 2018, Cancer research.

Discovery of AZ0108, an orally bioavailable phthalazinone PARP inhibitor that blocks centrosome clustering.

David A. Scott, S. Kazmirski, A. Ferguson, 2015, Bioorganic & medicinal chemistry letters.

Pyrimidinone nicotinamide mimetics as selective tankyrase and wnt pathway inhibitors suitable for in vivo pharmacology.

S. Kazmirski, Nancy Su, D. Ogg, 2015, ACS medicinal chemistry letters.

Identification of 4-aminopyrazolylpyrimidines as potent inhibitors of Trk kinases.

David A. Scott, Bin Wang, Yongxin Han, 2008, Journal of medicinal chemistry.

Discovery of Mcl-1-specific inhibitor AZD5991 and preclinical activity in multiple myeloma and acute myeloid leukemia

J. A. Hendricks, David M. Wilson, S. Kazmirski, 2018, Nature Communications.

In vitro and in vivo evaluation of 6-aminopyrazolyl-pyridine-3-carbonitriles as JAK2 kinase inhibitors.

David A. Scott, M. Lamb, Hai‐Jun Zhang, 2011, Bioorganic & medicinal chemistry letters.

Discovery of 5-chloro-N2-[(1S)-1-(5-fluoropyrimidin-2-yl)ethyl]-N4-(5-methyl-1H-pyrazol-3-yl)pyrimidine-2,4-diamine (AZD1480) as a novel inhibitor of the Jak/Stat pathway.

Jon Read, Mei Su, Minwei Ye, 2011, Journal of medicinal chemistry.

Computational approaches to molecular recognition.

M L Lamb, W L Jorgensen, W. L. Jorgensen, 1997, Current opinion in chemical biology.

Novel functional M1 selective muscarinic agonists. 2. Synthesis and structure-activity relationships of 3-pyrazinyl-1,2,5,6-tetrahydro-1-methylpyridines. Construction of a molecular model for the M1 pharmacophore.

J S Ward, M L Lamb, F. Bymaster, 1992, Journal of medicinal chemistry.

AZD1208, a potent and selective pan-Pim kinase inhibitor, demonstrates efficacy in preclinical models of acute myeloid leukemia.

Allan Wu, Paul D Lyne, Xiaolan Zheng, 2014, Blood.

Discovery of AZD4573, a Potent and Selective Inhibitor of CDK9 That Enables Short Duration of Target Engagement for the Treatment of Hematological Malignancies.

A. Ferguson, L. Drew, W. Shao, 2020, Journal of medicinal chemistry.

Accurate prediction of the relative potencies of members of a series of kinase inhibitors using molecular docking and MM-GBSA scoring.

Paul D Lyne, P. Lyne, M. Lamb, 2006, Journal of medicinal chemistry.

Targeting adenosine A2A receptor antagonism for treatment of cancer

Michelle L. Lamb, Miles Congreve, M. Congreve, 2018, Expert opinion on drug discovery.

Trk kinase inhibitors as new treatments for cancer and pain

M. Lamb, D. Yu, Tao Wang, 2009, Expert opinion on therapeutic patents.

Discovery of pyrazol-3-ylamino pyrazines as novel JAK2 inhibitors.

M. Lamb, Audrey M Davies, M. Zinda, 2009, Bioorganic & medicinal chemistry letters.

Discovery of novel benzylidene-1,3-thiazolidine-2,4-diones as potent and selective inhibitors of the PIM-1, PIM-2, and PIM-3 protein kinases.

A. Ferguson, P. Lyne, E. Keeton, 2012, Bioorganic & medicinal chemistry letters.

Modulating the strength of hydrogen bond acceptors to achieve low Caco2 efflux for oral bioavailability of PARP inhibitors blocking centrosome clustering.

David A. Scott, S. Kazmirski, P. Lyne, 2016, Bioorganic & medicinal chemistry letters.

Mechanistic Insights into a CDK9 Inhibitor Via Orthogonal Proteomics Methods.

J. A. Hendricks, L. Reiter, D. M. Molina, 2021, ACS chemical biology.

Structure Based Design of Non-Natural Peptidic Macrocyclic Mcl-1 Inhibitors.

Anthony D. Keefe, Christoph E. Dumelin, S. Kazmirski, 2017, ACS medicinal chemistry letters.

Discovery and mechanistic study of a small molecule inhibitor for motor protein KIFC1.

C. Chuaqui, N. Keen, Nancy Su, 2013, ACS chemical biology.

Ensemble-Based Docking Using Biased Molecular Dynamics

Diane Joseph-McCarthy, Michelle L. Lamb, Arthur J. Campbell, 2014, J. Chem. Inf. Model..

Estimation of the binding affinities of FKBP12 inhibitors using a linear response method.

M L Lamb, J Tirado-Rives, W L Jorgensen, 1999, Bioorganic & medicinal chemistry.

Free Ligand 1D NMR Conformational Signatures to Enhance Structure Based Drug Design of a Mcl-1 inhibitor (AZD5991) and other Synthetic Macrocycles.

Nichola L. Davies, E. Chiarparin, M. Lamb, 2019, Journal of medicinal chemistry.

Molecular Recognition of Carbohydrates: Interaction of Diols with Acetate Ion

W. L. Jorgensen, W. Damm, A. Frontera, 1996 .

Evaluating Free Energies of Binding and Conservation of Crystallographic Waters Using SZMAP

Demetri T. Moustakas, Diane Joseph-McCarthy, Michelle L. Lamb, 2015, J. Chem. Inf. Model..

Monte Carlo calculations on HIV-1 reverse transcriptase complexed with the non-nucleoside inhibitor 8-Cl TIBO: contribution of the L100I and Y181C variants to protein stability and biological activity.

M L Lamb, J Tirado-Rives, W L Jorgensen, 2000, Protein engineering.

A computational ensemble pharmacophore model for identifying substrates of P-glycoprotein.

Erik Evensen, J. Penzotti, P. Grootenhuis, 2002, Journal of medicinal chemistry.

Discovery and Optimization of the First ATP Competitive Type-III c-MET Inhibitor

E. Hennessy, T. Moss, C. Stubbs, 2023, Journal of medicinal chemistry.

Discovery of potent KIFC1 inhibitors using a method of integrated high-throughput synthesis and screening.

E. Hennessy, C. Chuaqui, Nancy Su, 2014, Journal of medicinal chemistry.

Design, docking, and evaluation of multiple libraries against multiple targets

Malin M. Young, J R Arnold, I D Kuntz, 2001, Proteins.

Discovery of Disubstituted Imidazo[4,5-b]pyridines and Purines as Potent TrkA Inhibitors.

Bin Wang, Yongxin Han, P. Lyne, 2012, ACS medicinal chemistry letters.

Investigations of neurotrophic inhibitors of FK506 binding protein via Monte Carlo simulations.

M L Lamb, W L Jorgensen, W. L. Jorgensen, 1998, Journal of medicinal chemistry.

Replacement of pyrazol-3-yl amine hinge binder with thiazol-2-yl amine: Discovery of potent and selective JAK2 inhibitors.

M. Lamb, Stephanos Ioannidis, Michelle L Lamb, 2010, Bioorganic & medicinal chemistry letters.

Trk kinase inhibitors as new treatments for cancer and pain

M. Lamb, D. Yu, Tao Wang, 2009, Expert opinion on therapeutic patents.

Discovery of potent KIFC1 inhibitors using a method of integrated high-throughput synthesis and screening.

E. Hennessy, C. Chuaqui, Nancy Su, 2014, Journal of medicinal chemistry.

SitePrint: Three-Dimensional Pharmacophore Descriptors Derived from Protein Binding Sites for Family Based Active Site Analysis, Classification, and Drug Design

Irwin D. Kuntz, James R. Arnold, Keith W. Burdick, 2004, J. Chem. Inf. Model..

Evaluating Free Energies of Binding and Conservation of Crystallographic Waters Using SZMAP

Alexander S. Bayden, D. Joseph-McCarthy, M. Lamb, 2015, J. Chem. Inf. Model..

Identification and Evaluation of Reversible Covalent Binders to Cys55 of Bfl-1 from a DNA-Encoded Chemical Library Screen

Anthony D. Keefe, Nancy Su, N. Selmi, 2024, ACS Medicinal Chemistry Letters.

Discovery, Optimization, and Biological Evaluation of Arylpyridones as Cbl-b Inhibitors.

V. Kantae, N. Grimster, M. Lamb, 2024, Journal of medicinal chemistry.

Discovery of a Novel Benzodiazepine Series of Cbl-b Inhibitors for the Enhancement of Antitumor Immunity.

Kathryn A. Giblin, N. Grimster, M. Lamb, 2023, ACS medicinal chemistry letters.

Identification of 4-aminopyrazolylpyrimidines as potent inhibitors of Trk kinases.

David A. Scott, Bin Wang, Yongxin Han, 2008, Journal of medicinal chemistry.