S. P. Romeril

发表

Discovery of GSK2656157: An Optimized PERK Inhibitor Selected for Preclinical Development.

A. Hassell, R. Gampe, J. Axten, 2013, ACS medicinal chemistry letters.

Structure-based design of potent and selective 3-phosphoinositide-dependent kinase-1 (PDK1) inhibitors.

S. Rabindran, N. Campobasso, V. Sudakin, 2011, Journal of medicinal chemistry.

Investigation into the absolute stereochemistry of the marine sponge alkaloid pyrinodemin A

S. P. Romeril, T. Claridge, J. Baldwin, 2003 .

On the synthesis of pyrinodemin A. Part 1: The location of the olefin

S. P. Romeril, T. Claridge, J. Baldwin, 2005 .

On the mechanism of the palladium(II)-catalyzed decarboxylative olefination of arene carboxylic acids. Crystallographic characterization of non-phosphine palladium(II) intermediates and observation of their stepwise transformation in Heck-like processes.

S. P. Romeril, A. Myers, Daisuke Tanaka, 2005, Journal of the American Chemical Society.

Discovery of a first-in-class reversible DNMT1-selective inhibitor with improved tolerability and efficacy in acute myeloid leukemia

Peter A. Jones, Philip J. Chapman, P. Grandi, 2021, Nature Cancer.

Discovery of 7-methyl-5-(1-{[3-(trifluoromethyl)phenyl]acetyl}-2,3-dihydro-1H-indol-5-yl)-7H-pyrrolo[2,3-d]pyrimidin-4-amine (GSK2606414), a potent and selective first-in-class inhibitor of protein kinase R (PKR)-like endoplasmic reticulum kinase (PERK).

L. Shewchuk, S. Rabindran, A. Hassell, 2012, Journal of medicinal chemistry.

Synthesis of marine sponge alkaloid hachijodine B and a comment on the structure of ikimine B and on the absolute configuration of niphatesine D

S. P. Romeril, J. Baldwin, Victor C. S. Lee, 2004 .

Identification of Potent, Selective, Cell-Active Inhibitors of the Histone Lysine Methyltransferase EZH2.

A. P. Graves, L. Lafrance, Christine Thompson, 2012, ACS medicinal chemistry letters.

Studies toward the total synthesis of the cytotoxic sponge alkaloid pyrinodemin A.

S. P. Romeril, T. Claridge, J. Baldwin, 2001, Organic letters.