M. Kilberg

发表

ER-stress-induced transcriptional regulation increases protein synthesis leading to cell death

R. Kaufman, J. Hur, M. Hatzoglou, 2013, Nature Cell Biology.

CHOP induces activating transcription factor 5 (ATF5) to trigger apoptosis in response to perturbations in protein homeostasis

J. McClintick, Donghui Zhou, R. Wek, 2013, Molecular biology of the cell.

Activation of the ATF3 gene through a co-ordinated amino acid-sensing response programme that controls transcriptional regulation of responsive genes following amino acid limitation.

Yuan-Xiang Pan, M. M. Thiaville, M. Kilberg, 2007, The Biochemical journal.

Asparagine synthetase chemotherapy.

Nigel G J Richards, N. Richards, M. Kilberg, 2006, Annual review of biochemistry.

Mass spectrometric quantification of asparagine synthetase in circulating leukemia cells from acute lymphoblastic leukemia patients.

Susan E Abbatiello, Susan E. Abbatiello, Thomas P Conrads, 2008, Journal of proteomics.

Influence of Amino Acid Metabolism on Embryonic Stem Cell Function and Differentiation.

N. Terada, J. Shan, M. Kilberg, 2016, Advances in nutrition.

C/EBP Homology Protein (CHOP) Interacts with Activating Transcription Factor 4 (ATF4) and Negatively Regulates the Stress-dependent Induction of the Asparagine Synthetase Gene*

N. Su, M. Kilberg, 2008, Journal of Biological Chemistry.

The transcription factor network associated with the amino acid response in mammalian cells.

J. Shan, M. Kilberg, M. Balasubramanian, 2012, Advances in nutrition.

Human CHAC1 Protein Degrades Glutathione, and mRNA Induction Is Regulated by the Transcription Factors ATF4 and ATF3 and a Bipartite ATF/CRE Regulatory Element*

I. Mungrue, J. Shan, M. Kilberg, 2015, The Journal of Biological Chemistry.

The C/ebp-Atf response element (CARE) location reveals two distinct Atf4-dependent, elongation-mediated mechanisms for transcriptional induction of aminoacyl-tRNA synthetase genes in response to amino acid limitation

Fan Zhang, J. Shan, M. Kilberg, 2016, Nucleic acids research.

Specificity of amino acid regulated gene expression: analysis of genes subjected to either complete or single amino acid deprivation

M. Kilberg, A. Bruhat, P. Fafournoux, 2009, Amino Acids.

Protein or amino acid deprivation differentially regulates the hepatic forkhead box protein A (FOXA) genes through an activating transcription factor‐4–independent pathway

N. Su, Thomas P. Yang, M. M. Thiaville, 2009, Hepatology.

Induction of p21 and p27 expression by amino acid deprivation of HepG2 human hepatoma cells involves mRNA stabilization.

M. Kilberg, Hong Chen, V. Leung-Pineda, 2004, The Biochemical journal.

Induction and decay of amino acid transport in the liver. Turnover of transport activity in isolated hepatocytes after stimulation by diabetes or glucagon.

M. Kilberg, M. Handlogten, 1984, The Journal of biological chemistry.

Placental anionic and cationic amino acid transporter expression in growth hormone overexpressing and null IGF-II or null IGF-I receptor mice.

A. Bartke, E. Dialynas, M. Kilberg, 1999, Placenta.

Response of placental amino acid transport to gestational age and intrauterine growth retardation

M. Kilberg, J. Matthews, D. Novak, 1998, Proceedings of the Nutrition Society.

Surviving Stress: Modulation of ATF4-Mediated Stress Responses in Normal and Malignant Cells

Inge M. N. Wortel, M. Kilberg, F. N. Leeuwen, 2017, Trends in Endocrinology & Metabolism.

Transcriptional induction of the human asparagine synthetase gene during the unfolded protein response does not require the ATF6 and IRE1/XBP1 arms of the pathway.

N. Su, M. Kilberg, Altin Gjymishka, 2009, The Biochemical journal.

Induction of early growth response gene 1 (EGR1) by endoplasmic reticulum stress is mediated by the extracellular regulated kinase (ERK) arm of the MAPK pathways.

E. Dudenhausen, J. Shan, M. Kilberg, 2019, Biochimica et biophysica acta. Molecular cell research.

Differences in the Molecular Mechanisms Involved in the Transcriptional Activation of the CHOP and Asparagine Synthetase Genes in Response to Amino Acid Deprivation or Activation of the Unfolded Protein Response*

A. Reimold, V. Carraro, J. Averous, 2002, The Journal of Biological Chemistry.

The mechanism for transcriptional activation of the human ATA2 transporter gene by amino acid deprivation is different than that for asparagine synthetase.

M. Kilberg, K. M. Leach, Hong Chen, 2002, The Journal of nutrition.

A Mitogen-activated Protein Kinase/Extracellular Signal-regulated Kinase Kinase (MEK)-dependent Transcriptional Program Controls Activation of the Early Growth Response 1 (EGR1) Gene during Amino Acid Limitation*

H. Baker, J. Shan, M. Kilberg, 2014, The Journal of Biological Chemistry.

Ontogeny of the neutral amino acid transporter SAT1/ATA1 in rat brain.

M. Kilberg, M. Weiss, J. Erickson, 2003, Brain research. Developmental brain research.

Glucocorticoid regulation of splanchnic glutamine, alanine, glutamate, ammonia, and glutathione fluxes.

M. Kilberg, B. K. Tamarappoo, T. Welbourne, 1993, The American journal of physiology.

Asparagine Synthetase Is Highly Expressed at Baseline in the Pancreas Through Heightened PERK Signaling

R. Bottino, A. Mukherjee, S. Husain, 2019, Cellular and molecular gastroenterology and hepatology.

Characteristics and hormonal regulation of amino acid transport system A in isolated rat hepatocytes.

M. Kilberg, M. Handlogten, E. F. Barber, 1985, Current topics in cellular regulation.

Amino Acid Transport, Cell Volume and Regulation of Cell Growth

D. Häussinger, F. Lang, M. Kilberg, 1992 .

Characteristics of an amino acid transport system in rat liver for glutamine, asparagine, histidine, and closely related analogs.

M. Kilberg, M. Handlogten, H. Christensen, 1980, The Journal of biological chemistry.

Substrate-dependent adaptive regulation and trans-inhibition of System A-mediated amino acid transport. Studies using rat hepatoma plasma membrane vesicles.

M. Kilberg, M. Handlogten, A. Fong, 1990, Biochimica et biophysica acta.

AMINO ACID TRANSPORT IN LIVER

D. Häussinger, M. Kilberg, 1992 .

Haem oxygenase 1 gene induction by glucose deprivation is mediated by reactive oxygen species via the mitochondrial electron-transport chain.

J. Melendez, M. Kilberg, A. Agarwal, 2003, The Biochemical journal.

Plasma membrane clustering of system y+ (CAT-1) amino acid transporter as detected by immunohistochemistry.

E. Block, O. Simell, M. Kilberg, 1994, The American journal of physiology.

Amino acid activation of amino acid transport system N early in primary cultures of rat hepatocytes

L. Weissbach, M. Kilberg, L. Weissbach, 1984, Journal of cellular physiology.

Neutral amino acid transport systems in Chinese hamster ovary cells.

M. Kilberg, D. Jayme, D. Oxender, 1981, The Journal of biological chemistry.

Cloning and expression of a novel Na(+)-dependent neutral amino acid transporter structurally related to mammalian Na+/glutamate cotransporters.

J. McNamara, R. Fremeau, A. Guadaño-Ferraz, 1993, The Journal of biological chemistry.

Evidence for two Na+-independent neutral amino acid transport systems in primary cultures of rat hepatocytes. Time-dependent changes in activity.

M. Kilberg, M. Handlogten, H. Christensen, 1982, The Journal of biological chemistry.

Elevated cJUN expression and an ATF/CRE site within the ATF3 promoter contribute to activation of ATF3 transcription by the amino acid response.

M. Kilberg, L. Fu, 2013, Physiological genomics.

Nutrient Control of Metabolism and Cell Signaling The Transcription Factor Network Associated With the Amino Acid Response in Mammalian Cells 1 , 2

J. Shan, M. Kilberg, M. Balasubramanian, 2012 .

Elevated ATF4 Expression, in the Absence of Other Signals, Is Sufficient for Transcriptional Induction via CCAAT Enhancer-binding Protein-activating Transcription Factor Response Elements*

J. Shan, M. Kilberg, Daima Örd, 2009, The Journal of Biological Chemistry.

Human CCAAT/Enhancer-binding Protein β Gene Expression Is Activated by Endoplasmic Reticulum Stress through an Unfolded Protein Response Element Downstream of the Protein Coding Sequence*

Yuan-Xiang Pan, E. Dudenhausen, M. Kilberg, 2004, Journal of Biological Chemistry.

MAPK signaling triggers transcriptional induction of cFOS during amino acid limitation of HepG2 cells.

E. Dudenhausen, Fan Zhang, J. Shan, 2015, Biochimica et biophysica acta.

An example of nutrient control of gene expression: amino acid-dependent regulation of asparagine synthetase.

D. Häussinger, M. Kilberg, U. Warskulat, 1996, Clinical nutrition.

Glucose Deprivation Induces Heme Oxygenase-1 Gene Expression by a Pathway Independent of the Unfolded Protein Response*

M. Kilberg, A. Agarwal, Se-Ho Chang, 2002, The Journal of Biological Chemistry.

Ontogeny and localization of the neutral amino acid transporter ASCT1 in rat brain.

M. Kilberg, M. Weiss, K. Anderson, 2001, Brain research. Developmental brain research.

Characterization of the amino acid response element within the human sodium-coupled neutral amino acid transporter 2 (SNAT2) System A transporter gene.

Yuan-Xiang Pan, M. Kilberg, C. Zhong, 2006, The Biochemical journal.

Auto-activation of c-JUN Gene by Amino Acid Deprivation of Hepatocellular Carcinoma Cells Reveals a Novel c-JUN-mediated Signaling Pathway*

E. Dudenhausen, J. Shan, M. Kilberg, 2011, The Journal of Biological Chemistry.

Amino acid control of asparagine synthetase: relation to asparaginase resistance in human leukemia cells.

S. Schuster, M. Kilberg, T. Kitoh, 1997, American Journal of Physiology.

Characterization of the nutrient-sensing response unit in the human asparagine synthetase promoter.

M. Kilberg, C. Zhong, Chin Chen, 2003, The Biochemical journal.

Amino-acid limitation induces transcription from the human C/EBPbeta gene via an enhancer activity located downstream of the protein coding sequence.

Yuan-Xiang Pan, E. Dudenhausen, M. Kilberg, 2005, The Biochemical journal.

Physiological importance of system A-mediated amino acid transport to rat fetal development.

M. Kilberg, D. Novak, M. Beveridge, 2002, American journal of physiology. Cell physiology.

Inhibition of endothelial cell amino acid transport System y+ by arginine analogs that inhibit nitric oxide synthase.

E. Block, R. D. Allison, O. Griffith, 1997, Biochimica et biophysica acta.

Plasma membrane domain localization and transcytosis of the glucagon-induced hepatic system A carrier.

M. Kilberg, R. Cariappa, 1992, The American journal of physiology.

Growth-dependent regulation of system A in SV40-transformed fetal rat hepatocytes.

M. Kilberg, M. Handlogten, 1988, The American journal of physiology.

Production of monospecific antibodies to a low-abundance hepatic membrane protein using nitrocellulose immobilized protein as antigen.

T. Chiles, T. W. O'brien, M. Kilberg, 1987, Analytical biochemistry.

Myeloma Cells Deplete Bone Marrow Glutamine and Inhibit Osteoblast Differentiation Limiting Asparagine Availability

G. Pruneri, C. Mancini, V. Franceschi, 2020, Cancers.

Demonstration of system y+L activity on the basal plasma membrane surface of rat placenta and developmentally regulated expression of 4F2HC mRNA.

J. Young, M. Kilberg, J. Matthews, 1997, Placenta.

Effect of low-protein diet-induced intrauterine growth retardation on rat placental amino acid transport.

M. Kilberg, D. Novak, M. Beveridge, 1996, The American journal of physiology.

Ontogeny of cationic amino acid transport systems in rat placenta.

M. Kilberg, D. Novak, M. Beveridge, 1994, The American journal of physiology.

Activation of the amino acid response modulates lineage specification during differentiation of murine embryonic stem cells.

N. Terada, J. Shan, M. Kilberg, 2013, American journal of physiology. Endocrinology and metabolism.

Transcriptional Control of the Human Sodium-coupled Neutral Amino Acid Transporter System A Gene by Amino Acid Availability Is Mediated by an Intronic Element*

M. Kilberg, Hong Chen, S. Palii, 2004, Journal of Biological Chemistry.

Glucose‐Responsive Expression of the Human Insulin Promoter in HepG2 Human Hepatoma Cells

T. Flotte, B. Burkhardt, M. Atkinson, 2003, Annals of the New York Academy of Sciences.

Cellular and molecular characterization of two novel asparagine synthetase gene mutations linked to asparagine synthetase deficiency

L. Bloom, M. Kilberg, Z. Qian, 2022, The Journal of biological chemistry.

Cellular and molecular characterization of two novel asparagine synthetase gene mutations linked to asparagine synthetase de ﬁ ciency

L. Bloom, M. Kilberg, Z. Qian, 2022 .

Amino acid-dependent increase in hepatic system N activity is linked to cell swelling.

M. Kilberg, B. Bode, 1991, The Journal of biological chemistry.

Molecular biology of mammalian amino acid transporters.

M. Kilberg, M. Malandro, 1996, Annual review of biochemistry.

Amino acid transport in isolated rat hepatocytes

M. Kilberg, 2005, The Journal of Membrane Biology.

Biosynthesis, Intracellular Targeting, and Degradation of the EAAC1 Glutamate/Aspartate Transporter in C6 Glioma Cells*

Wenbo Yang, M. Kilberg, 2002, The Journal of Biological Chemistry.

Mammalian Amino Acid Transport

D. Häussinger, M. Kilberg, 1992, Springer US.

Glutamine transport by basolateral plasma-membrane vesicles prepared from rabbit intestine.

M. Kilberg, S. Wilde, Stephen W. Wilde, 1991, The Biochemical journal.

Electron-transferring enzymes in the plasma membrane of the Ehrlich ascites tumor cell.

M. Kilberg, H. Christensen, 1979, Biochemistry.

Asparagine Synthetase in Cancer: Beyond Acute Lymphoblastic Leukemia

M. Bianchi, M. Kilberg, O. Bussolati, 2020, Frontiers in Oncology.

Asparagine synthetase expression alone is sufficient to induce l-asparaginase resistance in MOLT-4 human leukaemia cells.

M. Kilberg, B. Fletcher, A. Aslanian, 2001, The Biochemical journal.

System a transport activity in normal rat hepatocytes and transformed liver cells: Substrate protection from inactivation by sulfhydryl‐modifying reagents

T. Chiles, M. Kilberg, 1986, Journal of cellular physiology.

Sodium-dependent neutral amino acid transport by human liver plasma membrane vesicles.

M. Kilberg, M. Mailliard, 1990, The Journal of biological chemistry.

Characteristics and regulation of hepatic glutamine transport.

M. Kilberg, B. K. Tamarappoo, M. Mailliard, 1990, JPEN. Journal of parenteral and enteral nutrition.

Maintenance of glucagon-stimulated system A amino acid transport activity in rat liver plasma membrane vesicles.

M. Schenerman, M. Kilberg, 1986, Biochimica et biophysica acta.

Alignment of the transcription start site coincides with increased transcriptional activity from the human asparagine synthetase gene following amino acid deprivation of HepG2 cells.

M. Kilberg, Hong Chen, 2006, The Journal of nutrition.

Plasma membrane transport of 2-ketoisocaproate by rat hepatocytes in primary culture.

M. Kilberg, M. Gwynn, 1983, The Journal of biological chemistry.

An inhibitor of human asparagine synthetase suppresses proliferation of an L-asparaginase-resistant leukemia cell line.

N. Richards, M. Kilberg, J. Hiratake, 2006, Chemistry & biology.

The regulation of neutral amino acid transport in mammalian cells.

M. Kilberg, D. Oxender, M. Shotwell, 1983, Biochimica et biophysica acta.

A Caveolar Complex between the Cationic Amino Acid Transporter 1 and Endothelial Nitric-oxide Synthase May Explain the “Arginine Paradox”*

E. Block, M. Kilberg, K. McDonald, 1997, The Journal of Biological Chemistry.

Energization of amino acid transport in energy-depleted Ehrlich cells and plasma membrane vesicles.

G. Kimmel, M. Kilberg, H. Christensen, 1980, Biochimica et biophysica acta.

Mammalian amino acid transport: mechanisms and control.

D. Häussinger, M. Kilberg, Gamma-Glutamyl Compounds, 1992 .

The relation between membrane potential and the transport activity of system A and L in plasma membrane vesicles of the Ehrlich cell.

M. Kilberg, H. Christensen, 1980, Membrane biochemistry.

Induction of amino acid transport system A in rat hepatocytes is blocked by tunicamycin.

M. Kilberg, M. Handlogten, E. F. Barber, 1983, The Journal of biological chemistry.

Incomplete correspondence between repressive and substrate action by amino acids on transport systems A and N in monolayered rat hepatocytes.

M. Kilberg, M. Handlogten, H. Christensen, 1982, The Journal of biological chemistry.

Association of hepatic system A amino acid transporter with the membrane-cytoskeletal proteins ankyrin and fodrin.

E. Dudenhausen, M. Kilberg, M. Handlogten, 1996, Biochimica et biophysica acta.

Amino acid transport systems

A. Lajtha, J. Vadgama, G. Guidotti, 1984, Nature.

Characteristics of system ASC for transport of neutral amino acids in the isolated rat hepatocyte.

M. Kilberg, M. Handlogten, H. Christensen, 1981, The Journal of biological chemistry.

Activity and protein localization of multiple glutamate transporters in gestation day 14 vs. day 20 rat placenta.

J. Rothstein, J. Verlander, M. Kilberg, 1998, American journal of physiology. Cell physiology.

Recent advances in mammalian amino acid transport.

M. Kilberg, B. Stevens, D. Novak, 1993, Annual review of nutrition.

The role of stimulated amino acid transport in promoting glycogenesis in the irradiated rat.

M. Kilberg, O. Neuhaus, 1976, Radiation research.

Sequencing of Argonaute-bound microRNA/mRNA hybrids reveals regulation of the unfolded protein response by microRNA-320a

Tongjun Gu, Mingyi Xie, J. Shan, 2021, PLoS genetics.

Sequencing of Argonaute-bound miRNA/mRNA hybrids reveals regulation of the unfolded protein response by microRNA-320a

Tongjun Gu, Mingyi Xie, J. Shan, 2021, bioRxiv.

Metabolic Regulation of Manganese Superoxide Dismutase Expression via Essential Amino Acid Deprivation*

H. Nick, M. Kilberg, K. Aiken, 2008, Journal of Biological Chemistry.

Regulation of the ATF3 gene by a single promoter in response to amino acid availability and endoplasmic reticulum stress in human primary hepatocytes and hepatoma cells.

J. Shan, M. Kilberg, Jaclyn N. Hayner, 2018, Biochimica et biophysica acta. Gene regulatory mechanisms.

Genomic and proteomic analysis of transcription factor TFII-I reveals insight into the response to cellular stress

J. Strouboulis, G. Papadopoulos, Jianhong Hu, 2014, Nucleic acids research.

ATF4-dependent transcription mediates signaling of amino acid limitation

N. Su, J. Shan, M. Kilberg, 2009, Trends in Endocrinology & Metabolism.

Amino Acid Deprivation and Endoplasmic Reticulum Stress Induce Expression of Multiple Activating Transcription Factor-3 mRNA Species That, When Overexpressed in HepG2 Cells, Modulate Transcription by the Human Asparagine Synthetase Promoter*

M. Kilberg, Hong Chen, YuanXiang Pan, 2003, Journal of Biological Chemistry.

ATF4 Is a Mediator of the Nutrient-sensing Response Pathway That Activates the Human Asparagine Synthetase Gene*

M. Kilberg, Hong Chen, P. Bain, 2002, The Journal of Biological Chemistry.

Nutritional control of gene expression: how mammalian cells respond to amino acid limitation.

Hong Chen, M. Kilberg, V. Leung-Pineda, 2005, Annual review of nutrition.

Asparagine synthetase: regulation by cell stress and involvement in tumor biology.

M. Kilberg, M. Balasubramanian, E. Butterworth, 2013, American journal of physiology. Endocrinology and metabolism.

Multiple adaptive mechanisms affect asparagine synthetase substrate availability in asparaginase-resistant MOLT-4 human leukaemia cells.

M. Kilberg, A. Aslanian, 2001, The Biochemical journal.

Activation of the human asparagine synthetase gene by the amino acid response and the endoplasmic reticulum stress response pathways occurs by common genomic elements.

S. Schuster, H. Nick, C. Chen, 2000, The Journal of biological chemistry.

Amino acid‐regulated gene expression in eukaryotic cells

M. Kilberg, R. Hutson, R. O. Laine, 1994, FASEB journal : official publication of the Federation of American Societies for Experimental Biology.

Expression profiling after activation of amino acid deprivation response in HepG2 human hepatoma cells.

H. Baker, J. Shan, M. Kilberg, 2010, Physiological genomics.

Activated transcription via mammalian amino acid response elements does not require enhanced recruitment of the Mediator complex

E. Dudenhausen, M. Kilberg, C. Zhong, 2008, Nucleic acids research.

HIF1α Represses Cell Stress Pathways to Allow Proliferation of Hypoxic Fetal Cardiomyocytes.

A. McCulloch, M. Nóbrega, I. Aneas, 2015, Developmental cell.

Solubilization and reconstitution of hepatic System A-mediated amino acid transport. Preparation of proteoliposomes containing glucagon-stimulated transport activity.

M. Schenerman, M. Kilberg, D. S. Bracy, 1987, Biochimica et biophysica acta.

Cysteine as a system-specific substrate for transport system ASC in rat hepatocytes.

M. Kilberg, M. Handlogten, H. Christensen, 1979, Biochemical and biophysical research communications.

Hormonal regulation of hepatic amino acid transport.

M. Kilberg, O. Neuhaus, 1977, Journal of supramolecular structure.

Preferential binding of vasoactive intestinal peptide to hepatic nonparenchymal cells.

M. Wolfe, R. Misbin, M. Kilberg, 1985, The American journal of physiology.

Interaction of RNA-binding Proteins HuR and AUF1 with the Human ATF3 mRNA 3′-Untranslated Region Regulates Its Amino Acid Limitation-induced Stabilization*

M. Kilberg, Hong Chen, Yuan-Xiang Pan, 2005, Journal of Biological Chemistry.

PACT-mediated PKR activation acts as a hyperosmotic stress intensity sensor weakening osmoadaptation and enhancing inflammation

M. Hatzoglou, C. Cotton, P. Ramakrishnan, 2020, eLife.

Correlation between asparaginase sensitivity and asparagine synthetase protein content, but not mRNA, in acute lymphoblastic leukemia cell lines

S. Hunger, R. Harvey, M. Kilberg, 2008, Pediatric blood & cancer.

NUTRITIONAL CONTROL OF GENE EXPRESSION

M. Kilberg, V. Leung-Pineda, Hong Chen, 2005 .

ATF4-dependent Regulation of the JMJD3 Gene during Amino Acid Deprivation Can Be Rescued in Atf4-deficient Cells by Inhibition of Deacetylation*

T. Anthony, J. Shan, M. Kilberg, 2012, The Journal of Biological Chemistry.

Parkin is transcriptionally regulated by ATF4: evidence for an interconnection between mitochondrial stress and ER stress

David S. Park, W. Wurst, D. Trümbach, 2011, Cell Death and Differentiation.

Tumor suppressor BTG1 promotes PRMT1-mediated ATF4 function in response to cellular stress

B. Scheijen, G. Poelmans, J. Shan, 2015, Oncotarget.

Characterizing asparagine synthetase deficiency variants in lymphoblastoid cell lines

E. Dudenhausen, M. Kilberg, M. Merritt, 2023, JIMD reports.

Analysis of Enzyme Activity and Cellular Function for the N80S and S480F Asparagine Synthetase Variants Expressed in a Child with Asparagine Synthetase Deficiency

F. Lecoquierre, M. Kilberg, S. Bekri, 2022, International journal of molecular sciences.

Characterization of a novel variant in siblings with Asparagine Synthetase Deficiency.

S. Sacharow, E. Dudenhausen, M. Kilberg, 2017, Molecular genetics and metabolism.

Activation of the Unfolded Protein Response Pathway Induces Human Asparagine Synthetase Gene Expression*

S. Schuster, M. Kilberg, C. Zhong, 1999, The Journal of Biological Chemistry.

Transcriptional regulation of the human asparagine synthetase gene by carbohydrate availability.

S. Schuster, H. Nick, M. Kilberg, 1999, The Biochemical journal.

Eukaryotic gene expression: metabolite control by amino acids.

M. Kilberg, R. Hutson, R. O. Laine, 1996, Progress in nucleic acid research and molecular biology.

Amino Acid Deprivation Induces the Transcription Rate of the Human Asparagine Synthetase Gene through a Timed Program of Expression and Promoter Binding of Nutrient-responsive Basic Region/Leucine Zipper Transcription Factors as Well as Localized Histone Acetylation*

Yuan-Xiang Pan, E. Dudenhausen, M. Kilberg, 2004, Journal of Biological Chemistry.

The role of asparagine synthetase on nutrient metabolism in pancreatic disease.

Cheng-Yu Tsai, S. Husain, M. Kilberg, 2020, Pancreatology : official journal of the International Association of Pancreatology (IAP) ... [et al.].

MEK Signaling Is Required for Phosphorylation of eIF2α following Amino Acid Limitation of HepG2 Human Hepatoma Cells*

R. Kaufman, M. Kilberg, C. Zhong, 2008, Journal of Biological Chemistry.

Deprivation of protein or amino acid induces C/EBPbeta synthesis and binding to amino acid response elements, but its action is not an absolute requirement for enhanced transcription.

E. Dudenhausen, M. Kilberg, C. Zhong, 2008, The Biochemical journal.

Asparagine synthetase: Function, structure, and role in disease

M. Kilberg, R. McKenna, C. Lomelino, 2017, The Journal of Biological Chemistry.

Dynamic changes in genomic histone association and modification during activation of the ASNS and ATF3 genes by amino acid limitation.

J. Shan, M. Kilberg, M. Balasubramanian, 2013, The Biochemical journal.

Characterization and distribution of the neuronal glutamate transporter EAAC1 in rat brain.

R. Fremeau, M. Kilberg, M. Velaz-Faircloth, 1996, The American journal of physiology.

Despite Increased ATF4 Binding at the C/EBP-ATF Composite Site following Activation of the Unfolded Protein Response, System A Transporter 2 (SNAT2) Transcription Activity Is Repressed in HepG2 Cells*

J. Shan, M. Kilberg, S. Palii, 2008, Journal of Biological Chemistry.

An expression system for mammalian amino acid transporters using a stably maintained episomal vector.

M. Kilberg, J. Matthews, D. Novak, 1997, Analytical biochemistry.

Adaptive Regulation of the Cationic Amino Acid Transporter-1 (Cat-1) in Fao Cells*

S. L. Hyatt, M. Hatzoglou, M. Kilberg, 1997, The Journal of Biological Chemistry.

Amino acid-dependent inactivation of glucagon-induced system A transport activity in cultured rat hepatocytes

M. Kilberg, M. Handlogten, E. F. Barber, 1985, Molecular and Cellular Endocrinology.

Inactivation of amino acid transport in rat hepatocytes and hepatoma cells by PCMBS.

T. Chiles, M. Kilberg, K. L. Dudeck-Collart, 1988, The American journal of physiology.

Disulfide bond disrupting agents activate the unfolded protein response in EGFR- and HER2-positive breast tumor cells

P. Higgins, N. Terada, C. Heldermon, 2017, Oncotarget.

Expressed human hippocampal ASCT1 amino acid transporter exhibits a pH-dependent change in substrate specificity.

M. Kilberg, B. K. Tamarappoo, K. McDonald, 1996, Biochimica et biophysica acta.

Hormonal control of amino acid transport in the liver of rats exposed to whole-body gamma irradiation.

M. Kilberg, O. Neuhaus, 1978, Radiation research.

Enhanced mRNA content in response to amino acid starvation for a 73 kDa protein of the inner mitochondrial membrane.

T. Chiles, H. Nick, M. Kilberg, 1993, Biochemical and Biophysical Research Communications - BBRC.

Metabolomic Profiling of Asparagine Deprivation in Asparagine Synthetase Deficiency Patient-Derived Cells

M. Kilberg, M.C.Y. Chang, Stephen J. Staklinski, 2023, Nutrients.

Asparagine Synthetase Deficiency causes reduced proliferation of cells under conditions of limited asparagine.

A. Bye, M. Cowley, M. Dinger, 2015, Molecular genetics and metabolism.

Cloning of rat asparagine synthetase and specificity of the amino acid-dependent control of its mRNA content.

M. Kilberg, R. Hutson, 1994, The Biochemical journal.

1 Transcriptional regulatory mechanisms for the response to amino acid deprivation of mammalian cells

M. Kilberg, C. Zhong, R. McClellan, 2004 .

Genomic sequences necessary for transcriptional activation by amino acid deprivation of mammalian cells.

M. Kilberg, I. Barbosa-Tessmann, 2002, The Journal of nutrition.

Recent Advances in Nutritional Sciences Genomic Sequences Necessary for Transcriptional Activation by Amino Acid Deprivation of Mammalian Cells 1 , 2

M. Kilberg, I. Barbosa-Tessmann, 2002 .

CCAAT/Enhancer-binding Protein-β Is a Mediator of the Nutrient-sensing Response Pathway That Activates the Human Asparagine Synthetase Gene*

M. Kilberg, C. Zhong, Chin Chen, 2001, The Journal of Biological Chemistry.

Role of Sp1 and Sp3 in the Nutrient-regulated Expression of the Human Asparagine Synthetase Gene*

M. Kilberg, V. Leung-Pineda, 2002, The Journal of Biological Chemistry.

Solubilization and reconstitution characteristics of hepatic system A-mediated amino acid transport.

E. Dudenhausen, M. Kilberg, P. Fafournoux, 1989, The Journal of biological chemistry.

Regulation of neutral amino acid transport in hepatocytes isolated from adrenalectomized rats

M. Kilberg, T. Vida, E. F. Barber, 1983, Journal of cellular physiology.

Ontogeny and plasma-membrane domain localization of amino acid transport system L in rat liver.

M. Kilberg, D. Novak, M. Beveridge, 1994, The Biochemical journal.

Hormone-induced system A amino acid transport activity in rat liver plasma membrane and Golgi vesicles. Evidence for a differential sensitivity to inactivation by N-ethylmaleimide during carrier maturation.

M. Kilberg, R. Cariappa, 1990, The Journal of biological chemistry.

System A-mediated amino acid transport: metabolic control at the plasma membrane

M. Kilberg, 1986 .

Regulation of Hepatic Amino Acid Transport and Partial Purification of the System A Carrier

M. Kilberg, 1989 .

Measurement of amino acid transport by hepatocytes in suspension or monolayer culture.

M. Kilberg, 1989, Methods in enzymology.

Cis-inhibition, trans-inhibition, and repression of hepatic amino acid transport mediated by System A. Substrate specificity and other properties.

M. Kilberg, H. Han, M. Handlogten, 1986, The Journal of biological chemistry.

Adaptive regulation of neutral amino acid transport system A in rat H4 hepatoma cells

T. Chiles, M. Kilberg, H. Han, 1985, Journal of cellular physiology.

Neutral amino acid transport in hepatocytes isolated from streptozotocin-induced diabetic rats.

M. Kilberg, M. Handlogten, T. Vida, 1982, The Journal of biological chemistry.

Characterization of neutral and cationic amino acid transport in Xenopus oocytes

M. Campa, M. Kilberg, 1989, Journal of Cellular Physiology.

Identification of a System N‐Like Na+‐Dependent Glutamine Transport Activity in Rat Brain Neurons

M. Raizada, M. Kilberg, B. K. Tamarappoo, 1997, Journal of neurochemistry.

Nuclear retention of the induced mRNA following amino acid-dependent transcriptional regulation of mammalian ribosomal proteins L17 and S25.

M. Kilberg, N. Shay, R. O. Laine, 1994, The Journal of biological chemistry.

Activity and protein localization of multiple glutamate transporters in gestation day 14 vs. day 20 rat placenta.

J. Rothstein, J. Verlander, M. Kilberg, 1998, The American journal of physiology.

Heterogeneity of Na+-independent 2-aminobicyclo-(2,2,1)-heptane-2-carboxylic acid and L-leucine transport in isolated rat hepatocytes in primary culture.

M. Kilberg, M. Handlogten, L. Weissbach, 1982, Biochemical and biophysical research communications.

Transport of branched-chain amino acids and their corresponding 2-keto acids by mammalian cells.

M. Kilberg, M. Handlogten, 1988, Methods in enzymology.

Expression of the mammalian system A neutral amino acid transporter in Xenopus oocytes.

R. Tarnuzzer, M. Campa, N. Qian, 1990, The Journal of biological chemistry.

Transport system a is not responsive to hormonal stimulation in primary cultures of fetal rat hepatocytes.

M. Kilberg, M. Handlogten, 1982, Biochemical and biophysical research communications.

Identification of the protein responsible for hepatic system N amino acid transport activity.

M. Kilberg, B. K. Tamarappoo, M. Handlogten, 1992, The Journal of biological chemistry.

Functional reconstitution of the hepatic system N amino acid transport activity.

M. Kilberg, B. K. Tamarappoo, 1991, The Biochemical journal.

Molecular cloning of an amino acid-regulated mRNA (amino acid starvation-induced) in rat hepatoma cells.

H. Nick, M. Kilberg, N. Shay, 1990, The Journal of biological chemistry.