Chang-Lung Lee

发表

A next-generation dual-recombinase system for time- and host-specific targeting of pancreatic cancer

Christian Veltkamp, Ruby Banerjee, Ignacio Varela, 2014, Nature Medicine.

Assessing cardiac injury in mice with dual energy-microCT, 4D-microCT, and microSPECT imaging after partial heart irradiation.

G. Johnson, C. Badea, Y. Qi, 2014, International journal of radiation oncology, biology, physics.

p21 Protects “Super p53” Mice from the Radiation-Induced Gastrointestinal Syndrome

D. Kirsch, Chang-Lung Lee, J. M. Sullivan, 2012, Radiation research.

Radiation therapy and cardiotoxicity

D. Kirsch, Chang-Lung Lee, S. Yusuf, 2017 .

Characterization of cardiovascular injury in mice following partial-heart irradiation with clinically relevant dose and fractionation.

C. Badea, D. Kirsch, L. Mao, 2021, Radiotherapy and oncology : journal of the European Society for Therapeutic Radiology and Oncology.

Mice Lacking RIP3 Kinase are not Protected from Acute Radiation Syndrome

K. D. Castle, E. Moding, D. Kirsch, 2018, Radiation Research.

Inhibiting Glycogen Synthase Kinase-3 Mitigates the Hematopoietic Acute Radiation Syndrome in Mice

K. D. Castle, D. Kirsch, Chang-Lung Lee, 2014, Radiation research.

Investigating the Role of Inflammasome Caspases 1 and 11 in the Acute Radiation Syndrome

D. Kirsch, A. R. Daniel, Chang-Lung Lee, 2021, Radiation Research.

Acute DNA damage activates the tumour suppressor p53 to promote radiation-induced lymphoma

K. D. Castle, E. Moding, D. Kirsch, 2015, Nature Communications.

Assessing the Radiation Response of Lung Cancer with Different Gene Mutations Using Genetically Engineered Mice

Sayan Mukherjee, C. Badea, D. Kirsch, 2013, Front. Oncol..

Reining in Radiation Injury: HIF2α in the Gut

E. Moding, D. Kirsch, Chang-Lung Lee, 2014, Science Translational Medicine.

Generation of primary tumors with Flp recombinase in FRT-flanked p53 mice

E. Moding, D. Kirsch, Chang-Lung Lee, 2011, Disease Models & Mechanisms.

Epithelial Regeneration After Doxorubicin Arises Primarily From Early Progeny of Active Intestinal Stem Cells

Chang-Lung Lee, L. Samuelson, Theresa M. Keeley, 2021, Cellular and molecular gastroenterology and hepatology.

Sensitization of Vascular Endothelial Cells to Ionizing Radiation Promotes the Development of Delayed Intestinal Injury in Mice.

C. Badea, D. Kirsch, A. R. Daniel, 2019, Radiation research.

Transplantation of Unirradiated Bone Marrow Cells after Total-Body Irradiation Prevents the Development of Thymic Lymphoma in Mice through Niche Competition

Chang-Lung Lee, Stephanie Hasapis, Isibel Caraballo, 2020, Radiation Research.

Blocking Cyclin-Dependent Kinase 4/6 During Single Dose Versus Fractionated Radiation Therapy Leads to Opposite Effects on Acute Gastrointestinal Toxicity in Mice.

D. Kirsch, A. R. Daniel, Chang-Lung Lee, 2018, International journal of radiation oncology, biology, physics.

Temporary knockdown of p53 during focal limb irradiation increases the development of sarcomas

Sara R. Selitsky, S. Selitsky, D. Kirsch, 2022, bioRxiv.

Sensitization of Endothelial Cells to Ionizing Radiation Exacerbates Delayed Radiation Myelopathy in Mice

William T. Harrison, M. Oldham, D. Kirsch, 2021, Radiation Research.

Inhibiting Glycogen Synthase Kinase-3 Mitigates the Hematopoietic Acute Radiation Syndrome in a Sex- and Strain-dependent Manner in Mice

D. Kirsch, A. R. Daniel, Chang-Lung Lee, 2020, Health physics.

NF1+/- Hematopoietic Cells Accelerate Malignant Peripheral Nerve Sheath Tumor Development without Altering Chemotherapy Response.

W. Eward, A. Lazar, D. Kirsch, 2017, Cancer research.

The p53 Transactivation Domain 1-Dependent Response to Acute DNA Damage in Endothelial Cells Protects against Radiation-Induced Cardiac Injury

D. Kirsch, L. Attardi, Chang-Lung Lee, 2021, Radiation Research.

Tracing Tumor Evolution in Sarcoma Reveals Clonal Origin of Advanced Metastasis

B. Alman, Sin-Ho Jung, D. Kirsch, 2019, Cell reports.

Notch-Induced Myeloid Reprogramming in Spontaneous Pancreatic Ductal Adenocarcinoma by Dual Genetic Targeting.

E. Moding, D. Saur, M. Heikenwalder, 2018, Cancer research.

Atm deletion with dual recombinase technology preferentially radiosensitizes tumor endothelium.

K. D. Castle, E. Moding, S. Zha, 2014, The Journal of clinical investigation.

MicroRNA-182 drives metastasis of primary sarcomas by targeting multiple genes.

Jeffrey K. Mito, D. Kirsch, D. Lev, 2014, The Journal of clinical investigation.

Selective ERBB2 and BCL2 Inhibition Is Synergistic for Mitochondrial-Mediated Apoptosis in MDS and AML Cells

N. Spector, Angel Y. F. Kam, D. Rizzieri, 2021, Molecular Cancer Research.

Role of p53 in regulating tissue response to radiation by mechanisms independent of apoptosis.

D. Kirsch, Jordan M. Blum, Chang-Lung Lee, 2013, Translational cancer research.

Tumor cells, but not endothelial cells, mediate eradication of primary sarcomas by stereotactic body radiation therapy

K. D. Castle, E. Moding, D. Kirsch, 2015, Science Translational Medicine.

Whole-Exome Sequencing of Radiation-Induced Thymic Lymphoma in Mouse Models Identifies Notch1 Activation as a Driver of p53 Wild-Type Lymphoma

K. Owzar, D. Kirsch, A. R. Daniel, 2021, Cancer Research.

Activation of Notch1 drives the development of radiation-induced thymic lymphoma in p53 wild-type mice

K. Owzar, D. Kirsch, A. R. Daniel, 2020, bioRxiv.

An extra copy of p53 suppresses development of spontaneous Kras-driven but not radiation-induced cancer.

K. D. Castle, E. Moding, D. Kirsch, 2016, JCI insight.

Mutational landscape in genetically engineered, carcinogen-induced, and radiation-induced mouse sarcoma.

K. Owzar, D. Kirsch, A. R. Daniel, 2019, JCI insight.

Characterizing the Potency and Impact of Carbon Ion Therapy in a Primary Mouse Model of Soft Tissue Sarcoma

K. D. Castle, Sin-Ho Jung, M. Durante, 2018, Molecular Cancer Therapeutics.

Spectrotemporal CT data acquisition and reconstruction at low dose.

Darin P Clark, Cristian T Badea, Chang-Lung Lee, 2015, Medical physics.

p53 Functions in Endothelial Cells to Prevent Radiation-Induced Myocardial Injury in Mice

E. Moding, D. Kirsch, H. Rockman, 2012, Science Signaling.

A Novel Wide Field-of-View Imaging System for Real-Time, Intra-Operative Tumor Bed Assessment

Jeffrey K. Mito, M. Bawendi, L. Griffith, 2010 .

Intraoperative detection and removal of microscopic residual sarcoma using wide-field imaging

Jeffrey K. Mito, M. Bawendi, L. Griffith, 2012, Cancer.

Deletion of Atm in Tumor but not Endothelial Cells Improves Radiation Response in a Primary Mouse Model of Lung Adenocarcinoma.

Lixia Luo, K. D. Castle, Chang-Lung Lee, 2018, Cancer research.

Mis-splicing Drives Loss of Function of p53E224D Point Mutation

D. Kirsch, Chang-Lung Lee, Yan Ma, 2023, bioRxiv.

p53 promotes revival stem cells in the regenerating intestine after severe radiation injury

J. Wrana, A. Minn, D. Kirsch, 2023, bioRxiv.

MicroRNA-182 drives metastasis of primary sarcomas by targeting multiple genes.

Jeffrey K. Mito, D. Kirsch, D. Lev, 2016, The Journal of clinical investigation.

Spectrotemporal CT data acquisition and reconstruction at low dose.

C. Badea, D. Clark, D. Kirsch, 2015, Medical physics.

MicroRNA-182 drives metastasis of primary sarcomas by targeting multiple genes.

Jeffrey K. Mito, D. Kirsch, D. Lev, 2014, The Journal of clinical investigation.

NF1+/- Hematopoietic Cells Accelerate Malignant Peripheral Nerve Sheath Tumor Development without Altering Chemotherapy Response.

W. Eward, A. Lazar, D. Kirsch, 2017, Cancer research.

Mutational landscape in genetically engineered, carcinogen-induced, and radiation-induced mouse sarcoma.

K. Owzar, D. Kirsch, A. R. Daniel, 2019, JCI insight.

p53 promotes revival stem cells in the regenerating intestine after severe radiation injury

C. Koumenis, Chang-Lung Lee, Yan Ma, 2024, Nature communications.