S. Sahni

发表

The metastasis suppressor, NDRG1, differentially modulates the endoplasmic reticulum stress response.

D. Richardson, A. M. Merlot, G. Porter, 2019, Biochimica et biophysica acta. Molecular basis of disease.

P-glycoprotein Mediates Drug Resistance via a Novel Mechanism Involving Lysosomal Sequestration*

D. Richardson, S. Sahni, A. Arvind, 2013, The Journal of Biological Chemistry.

Guidelines for the use and interpretation of assays formonitoring autophagy (3rd edition)

Sangeeta Khare, Xin Qi, Ying Wang, 2016 .

In Vitro Characterization of the Pharmacological Properties of the Anti-Cancer Chelator, Bp4eT, and Its Phase I Metabolites

D. Richardson, K. Vávrová, D. Kalinowski, 2015, PloS one.

A Nitric Oxide Storage and Transport System That Protects Activated Macrophages from Endogenous Nitric Oxide Cytotoxicity*

D. Richardson, S. Sahni, C. Hawkins, 2016, The Journal of Biological Chemistry.

Ectopic expression of Atleafy in Brassica juncea cv. Geeta for early flowering

S. Sahni, A. Narula, P. Srivastava, 2013, Physiology and Molecular Biology of Plants.

Impact of Climate Change on Functional AM Fungi in Rhizosphere

Manoj Kumar Singh, S. Sahni, Anita Narang, 2021, Soil Biology.

Data independent acquisition of plasma biomarkers of response to neoadjuvant chemotherapy in pancreatic ductal adenocarcinoma.

J. Samra, M. Molloy, S. Sahni, 2020, Journal of proteomics.

Nitric oxide reduces oxidative stress in cancer cells by forming dinitrosyliron complexes.

Jason R. Hickok, S. Sahni, D. Thomas, 2018, Nitric oxide : biology and chemistry.

protein kinase in skeletal muscle Energy-sensing and signaling by AMP-activated

C. S. Bickel, B. Lay, J. Rubenson, 2015 .

The Metastasis Suppressor, N-MYC Downstream-regulated Gene-1 (NDRG1), Down-regulates the ErbB Family of Receptors to Inhibit Downstream Oncogenic Signaling Pathways*

D. Richardson, D. Kalinowski, S. Sahni, 2015, The Journal of Biological Chemistry.

The role of NDRG1 in the pathology and potential treatment of human cancers

D. Richardson, C. S. Lee, D. Kalinowski, 2013, Journal of Clinical Pathology.

Nitric Oxide Suppresses Tumor Cell Migration through N-Myc Downstream-regulated Gene-1 (NDRG1) Expression

M. Bonini, Jason R. Hickok, S. Sahni, 2011, The Journal of Biological Chemistry.

Lysosomal membrane stability plays a major role in the cytotoxic activity of the anti-proliferative agent, di-2-pyridylketone 4,4-dimethyl-3-thiosemicarbazone (Dp44mT).

D. Richardson, D. Kalinowski, S. Sahni, 2016, Biochimica et biophysica acta.

Unraveling the AM fungal community for understanding its ecosystem resilience to changed climate in agroecosystems

F. Oehl, Mahaveer P. Sharma, A. Prakash, 2021, Symbiosis.

Role of ABCB1 in Mediating Chemo-resistance of Triple Negative Breast Cancers.

A. Spillane, S. Sahni, P. Jansson, 2021, Bioscience reports.

Quick Cycle neoadjuvant chemotherapy in squamous cell carcinoma of cervix

S. Sahni, S. Agarwal, S. Rajaram, 2005 .

"Quick Cycle" neoadjuvant chemotherapy in squamous cell "Quick Cycle" neoadjuvant chemotherapy in squamous cell "Quick Cycle" neoadjuvant chemotherapy in squamous cell "Quick Cycle" neoadjuvant chemotherapy in squamous cell "Quick Cycle" neoadjuvant chemotherapy in squamous cell

S. Sahni, N. Goel, S. Agarwal, 2005 .

Two mechanisms involving the autophagic and proteasomal pathways process the metastasis suppressor protein, N-myc downstream regulated gene 1.

D. Richardson, K. Park, S. Sahni, 2019, Biochimica et biophysica acta. Molecular basis of disease.

Dinitrosyliron complexes are the most abundant nitric oxide-derived cellular adduct: biological parameters of assembly and disappearance.

Jason R. Hickok, S. Sahni, A. Arvind, 2011, Free radical biology & medicine.

PSMD11, PTPRM and PTPRB as novel biomarkers of pancreatic cancer progression.

J. Samra, A. Gill, M. Molloy, 2020, Biochimica et biophysica acta. General subjects.

Serum Biomarker Panel for Diagnosis and Prognosis of Pancreatic Ductal Adenocarcinomas

J. Samra, A. Gill, S. Sahni, 2021, Frontiers in Oncology.

Increased postoperative pancreatic fistula rate after distal pancreatectomy compared with pancreatoduodenectomy is attributable to a difference in acinar scores

J. Samra, A. Gill, S. Sahni, 2021, Journal of hepato-biliary-pancreatic sciences.

Cellular Uptake of the Antitumor Agent Dp44mT Occurs via a Carrier/Receptor-Mediated Mechanism

D. Richardson, D. Kalinowski, S. Sahni, 2013, Molecular Pharmacology.

Regulation and control of nitric oxide (NO) in macrophages: Protecting the "professional killer cell" from its own cytotoxic arsenal via MRP1 and GSTP1.

D. Wink, D. Richardson, S. Sahni, 2017, Biochimica et biophysica acta. General subjects.

Autophagy: A Key Player in Pancreatic Cancer Progression and a Potential Drug Target

N. Pavlakis, J. Samra, S. Sahni, 2022, Cancers.

Guidelines for the use and interpretation of assays for monitoring autophagy (4th edition)1

Mark R. Marten, Erinna F. Lee, Dana L. Miller, 2021, Autophagy.

A Critical Assessment of Postneoadjuvant Therapy Pancreatic Cancer Regression Grading Schemes With a Proposal for a Novel Approach.

N. Pavlakis, A. Chou, J. Samra, 2020, The American journal of surgical pathology.

Tissue biomarker panel as a surrogate marker for squamous subtype of pancreatic cancer.

N. Pavlakis, J. Samra, A. Gill, 2020, European journal of surgical oncology : the journal of the European Society of Surgical Oncology and the British Association of Surgical Oncology.

The anti-tumor agent, Dp44mT, promotes nuclear translocation of TFEB via inhibition of the AMPK-MTORC1 axis.

D. Richardson, S. Sahni, S. Krishan, 2020, Biochimica et biophysica acta. Molecular basis of disease.

Making a case for albumin – a highly promising drug-delivery system.

D. Richardson, D. Kalinowski, S. Sahni, 2015, Future medicinal chemistry.

Identification of differential phosphorylation and sub-cellular localization of the metastasis suppressor, NDRG1.

D. Richardson, K. Park, D. Kalinowski, 2018, Biochimica et biophysica acta. Molecular basis of disease.

Redox cycling metals: Pedaling their roles in metabolism and their use in the development of novel therapeutics.

T. Ganz, D. Richardson, S. Toyokuni, 2016, Biochimica et biophysica acta.

Letter to the Editor: “Analysis of the Interaction of Dp44mT with Human Serum Albumin and Calf Thymus DNA Using Molecular Docking and Spectroscopic Techniques”

D. Richardson, D. Kalinowski, S. Sahni, 2016, International journal of molecular sciences.

Novel Mechanism of Cytotoxicity for the Selective Selenosemicarbazone, 2-Acetylpyridine 4,4-Dimethyl-3-selenosemicarbazone (Ap44mSe): Lysosomal Membrane Permeabilization.

D. Richardson, D. Kalinowski, S. Sahni, 2016, Journal of medicinal chemistry.

Exploiting Cancer Metal Metabolism using Anti-Cancer Metal- Binding Agents.

D. Richardson, D. Kalinowski, S. Sahni, 2019, Current medicinal chemistry.

Duodenal Cytochrome b (DCYTB) in Iron Metabolism: An Update on Function and Regulation

D. Richardson, S. Sahni, D. Lane, 2015, Nutrients.

The Anticancer Agent, Di-2-Pyridylketone 4,4-Dimethyl-3-Thiosemicarbazone (Dp44mT), Up-Regulates the AMPK-Dependent Energy Homeostasis Pathway in Cancer Cells.

D. Richardson, S. Sahni, S. Krishan, 2016, Biochimica et biophysica acta.

The renaissance of polypharmacology in the development of anti-cancer therapeutics: Inhibition of the "Triad of Death" in cancer by Di-2-pyridylketone thiosemicarbazones.

D. Richardson, D. Kalinowski, S. Sahni, 2015, Pharmacological research.

A novel class of thiosemicarbazones show multi-functional activity for the treatment of Alzheimer's disease.

D. Hibbs, D. Richardson, D. Kalinowski, 2017, European journal of medicinal chemistry.

Potentiating the cellular targeting and anti-tumor activity of Dp44mT via binding to human serum albumin: two saturable mechanisms of Dp44mT uptake by cells

D. Hibbs, M. Doddareddy, D. Richardson, 2015, Oncotarget.

Di-2-pyridylketone 4,4-Dimethyl-3-thiosemicarbazone (Dp44mT) Overcomes Multidrug Resistance by a Novel Mechanism Involving the Hijacking of Lysosomal P-Glycoprotein (Pgp)*

D. Richardson, S. Sahni, N. Seebacher, 2015, The Journal of Biological Chemistry.

Targeting the Metastasis Suppressor, N-Myc Downstream Regulated Gene-1, with Novel Di-2-Pyridylketone Thiosemicarbazones: Suppression of Tumor Cell Migration and Cell-Collagen Adhesion by Inhibiting Focal Adhesion Kinase/Paxillin Signaling

M. Zheng, D. Richardson, Xiongzhi Wangpu, 2016, Molecular Pharmacology.

Roads to melanoma: Key pathways and emerging players in melanoma progression and oncogenic signaling.

D. Richardson, D. Kalinowski, A. M. Merlot, 2016, Biochimica et biophysica acta.

Emerging Role of Autophagy in the Development and Progression of Oral Squamous Cell Carcinoma

S. Sahni, P. Jansson, Yomna S. Abd El-Aziz, 2021, Cancers.

The Role of the Antioxidant Response in Mitochondrial Dysfunction in Degenerative Diseases: Cross-Talk between Antioxidant Defense, Autophagy, and Apoptosis

D. Richardson, D. Kalinowski, S. Sahni, 2019, Oxidative medicine and cellular longevity.

Mechanically stressed cancer microenvironment: Role in pancreatic cancer progression.

J. Samra, H. Zreiqat, S. Sahni, 2020, Biochimica et biophysica acta. Reviews on cancer.

Molecular functions of the iron-regulated metastasis suppressor, NDRG1, and its potential as a molecular target for cancer therapy.

D. Richardson, K. Park, D. Kalinowski, 2012, Biochimica et biophysica acta.

The molecular effect of metastasis suppressors on Src signaling and tumorigenesis: new therapeutic targets

M. Zheng, D. Richardson, Zhihai Peng, 2015, Oncotarget.

Frataxin and the molecular mechanism of mitochondrial iron-loading in Friedreich's ataxia.

D. Richardson, D. Kalinowski, S. Sahni, 2016, Clinical science.

Mechanism of the induction of endoplasmic reticulum stress by the anti-cancer agent, di-2-pyridylketone 4,4-dimethyl-3-thiosemicarbazone (Dp44mT): Activation of PERK/eIF2α, IRE1α, ATF6 and calmodulin kinase.

D. Richardson, Yu Yu, D. Kalinowski, 2016, Biochemical pharmacology.

Copper and conquer: copper complexes of di-2-pyridylketone thiosemicarbazones as novel anti-cancer therapeutics.

D. Richardson, K. Park, D. Kalinowski, 2016, Metallomics : integrated biometal science.

Drain fluid biomarkers for prediction and diagnosis of clinically relevant postoperative pancreatic fistula: A narrative review

J. Samra, S. Sahni, A. Mittal, 2022, World journal of gastrointestinal surgery.

Small Molecule KRAS Inhibitors: The Future for Targeted Pancreatic Cancer Therapy?

N. Pavlakis, J. Samra, A. Gorfe, 2020, Cancers.

NDRG1 as a molecular target to inhibit the epithelial-mesenchymal transition: the case for developing inhibitors of metastasis.

D. Richardson, S. Sahni, S. Krishan, 2014, Future medicinal chemistry.

Metastasis suppressor, NDRG1, mediates its activity through signaling pathways and molecular motors.

M. Zheng, Daohai Zhang, D. Richardson, 2013, Carcinogenesis.

Tumor stressors induce two mechanisms of intracellular P-glycoprotein–mediated resistance that are overcome by lysosomal-targeted thiosemicarbazones

D. Richardson, K. Park, S. Sahni, 2018, The Journal of Biological Chemistry.

AMP kinase (PRKAA1)

D. Richardson, S. Sahni, S. Krishan, 2014, Journal of Clinical Pathology.

The proto-oncogene c-Src and its downstream signaling pathways are inhibited by the metastasis suppressor, NDRG1

M. Zheng, D. Richardson, D. Kalinowski, 2015, Oncotarget.

Regulation of autophagy and apoptosis by Dp44mT-mediated activation of AMPK in pancreatic cancer cells.

D. Richardson, S. Sahni, P. Jansson, 2020, Biochimica et biophysica acta. Molecular basis of disease.

Novel Thiosemicarbazones Regulate the Signal Transducer and Activator of Transcription 3 (STAT3) Pathway: Inhibition of Constitutive and Interleukin 6–Induced Activation by Iron Depletion

D. Richardson, D. Kalinowski, S. Sahni, 2015, Molecular Pharmacology.

Cellular iron uptake, trafficking and metabolism: Key molecules and mechanisms and their roles in disease.

D. Richardson, D. Kalinowski, S. Sahni, 2015, Biochimica et biophysica acta.

The mechanistic role of chemically diverse metal ions in the induction of autophagy

D. Richardson, S. Sahni, P. Jansson, 2017, Pharmacological research.

The Metastasis Suppressor, N-myc Downstream-regulated Gene 1 (NDRG1), Inhibits Stress-induced Autophagy in Cancer Cells

D. Richardson, D. Kalinowski, S. Sahni, 2014, The Journal of Biological Chemistry.

Dinitrosyl Iron Complexes and their Role in Patho-physiological Conditions

S. Sahni, 2011 .

Interplay of the iron-regulated metastasis suppressor NDRG1 with epidermal growth factor receptor (EGFR) and oncogenic signaling

D. Richardson, S. Sahni, Z. Kovacevic, 2017, The Journal of Biological Chemistry.

Glutathione S-transferase and MRP1 form an integrated system involved in the storage and transport of dinitrosyl-dithiolato iron complexes in cells.

D. Richardson, D. Kalinowski, S. Sahni, 2014, Free radical biology & medicine.

Autophagy: A Promising Target for Triple Negative Breast Cancers.

S. Sahni, P. Jansson, Yomna S. Abd El-Aziz, 2021, Pharmacological research.

The Prognostic and Predictive Role of the Neutrophil-to-Lymphocyte Ratio (NLR), Platelet-to-Lymphocyte Ratio (PLR), and Lymphocyte-to-Monocyte Ratio (LMR) as Biomarkers in Resected Pancreatic Cancer

N. Pavlakis, E. Colvin, J. Samra, 2023, Journal of clinical medicine.

Identification of Novel Biomarkers in Pancreatic Tumor Tissue to Predict Response to Neoadjuvant Chemotherapy

N. Pavlakis, J. Samra, A. Gill, 2020, Frontiers in Oncology.

The Right Treatment Strategy for the Right Patient: A Biomarker-Driven Approach to Neoadjuvant vs. Surgery-First Management of Resectable and Borderline Resectable Pancreatic Cancer

N. Pavlakis, E. Colvin, A. Chou, 2022, Cancers.

NDRG1 suppresses basal and hypoxia-induced autophagy at both the initiation and degradation stages and sensitizes pancreatic cancer cells to lysosomal membrane permeabilization.

D. Richardson, K. Park, S. Sahni, 2020, Biochimica et biophysica acta. General subjects.

Targeting Wnt/tenascin C-mediated cross talk between pancreatic cancer cells and stellate cells via activation of the metastasis suppressor NDRG1

D. Richardson, M. Apte, S. Sahni, 2022, The Journal of biological chemistry.

Breaking the cycle: Targeting of NDRG1 to inhibit bi‐directional oncogenic cross‐talk between pancreatic cancer and stroma

M. Pajic, D. Richardson, K. Park, 2021, FASEB journal : official publication of the Federation of American Societies for Experimental Biology.

Optimal Upfront Treatment in Surgically Resectable Pancreatic Cancer Candidates: A High-Volume Center Retrospective Analysis

N. Pavlakis, J. Samra, A. Gill, 2021, Journal of clinical medicine.

Urinary metabolite prognostic biomarker panel for pancreatic ductal adenocarcinomas.

J. Samra, A. Gill, S. Sahni, 2021, Biochimica et biophysica acta. General subjects.

IRON METABOLISM AND AUTOPHAGY: A POORLY EXPLORED RELATIONSHIP THAT HAS IMPORTANT CONSEQUENCES FOR HEALTH AND DISEASE

D. Richardson, S. Sahni, P. Jansson, 2015, Nagoya journal of medical science.

Gene of the month: BECN1

D. Richardson, S. Sahni, P. Jansson, 2014, Journal of Clinical Pathology.

Adenosine Monophosphate–Activated Kinase and Its Key Role in Catabolism: Structure, Regulation, Biological Activity, and Pharmacological Activation

D. Richardson, S. Sahni, S. Krishan, 2015, Molecular Pharmacology.

The use of iron chelators in biocidal compositions: evaluation of patent, WO2014059417A1

D. Richardson, S. Sahni, S. Krishan, 2015, Expert opinion on therapeutic patents.

A unique urinary metabolomic signature for the detection of pancreatic ductal adenocarcinoma

J. Samra, A. Gill, S. Sahni, 2020, International journal of cancer.

Postoperative pancreatitis and pancreatic fistulae: a review of current evidence.

J. Samra, S. Sahni, A. Mittal, 2023, HPB : the official journal of the International Hepato Pancreato Biliary Association.

Erratum to: Guidelines for the use and interpretation of assays for monitoring autophagy (3rd edition) (Autophagy, 12, 1, 1-222, 10.1080/15548627.2015.1100356

Sara W. Bird, Erinna F. Lee, Michael D. Kim, 2016 .

Editorial :Guidelines for the use and interpretation of assays for monitoring autophagy (3rd edition). DOI: 10.1080/15548627.2015.1100356;WOS:000373595400001; 2-s2.0-85013763791&;PMID: 26799652

Lee, Duchen, Izzo, 2016 .

The role of diagnostic, prognostic, and predictive biomarkers in the management of early pancreatic cancer.

N. Pavlakis, E. Colvin, J. Samra, 2023, Journal of cancer research and clinical oncology.

Drain fluid biomarkers for the diagnosis of clinically relevant postoperative pancreatic fistula: a diagnostic accuracy systematic review and meta-analysis

J. Samra, S. Sahni, A. Mittal, 2023, International journal of surgery.

Copper that cancer with lysosomal love!

D. Richardson, S. Sahni, Z. Kovacevic, 2016, Aging.

Heterogeneous tumor microenvironment in pancreatic ductal adenocarcinoma: An emerging role of single‐cell analysis

J. Samra, A. Gill, S. Sahni, 2023, Cancer medicine.

Metastasis suppressor, NDRG1, mediates its activity through signaling pathways and molecular motors.

M. Zheng, Daohai Zhang, D. Richardson, 2013, Carcinogenesis.

Nitric oxide reduces oxidative stress in cancer cells by forming dinitrosyliron complexes.

Jason R. Hickok, S. Sahni, Douglas D. Thomas, 2018, Nitric oxide : biology and chemistry.

Inhibition of autophagy initiation: A novel strategy for oral squamous cell carcinomas.

S. Sahni, P. Jansson, L. Sioson, 2023, Biochimica et biophysica acta. Molecular cell research.

Ectopic expression of Atleafy in Brassica juncea cv. Geeta for early flowering

S. Sahni, A. Narula, P. Srivastava, 2013, Physiology and Molecular Biology of Plants.

Drain fluid biomarkers for prediction and diagnosis of clinically relevant postoperative pancreatic fistula: A narrative review

J. Samra, S. Sahni, A. Mittal, 2022, World journal of gastrointestinal surgery.

Nitric Oxide Suppresses Tumor Cell Migration Through N-Myc Downstream Regulated Gene-1 (NDRG1) Expression: the Role of Chelatable Iron

Jason R. Hickok, S. Sahni, Y. Mikhed, 2011 .

The metastasis suppressor, NDRG1, differentially modulates the endoplasmic reticulum stress response.

G. Porter, S. Sahni, E. Lim, 2019, Biochimica et biophysica acta. Molecular basis of disease.

Targeting autophagy in antitumor agent design: furthering the 'lysosomal love' strategy.

D. Richardson, D. Kalinowski, S. Sahni, 2016, Future medicinal chemistry.

Novel combinatorial autophagy inhibition therapy for triple negative breast cancers.

S. Sahni, P. Jansson, L. Sioson, 2024, European journal of pharmacology.

Non-Surgical Interventions for the Prevention of Clinically Relevant Postoperative Pancreatic Fistula—A Narrative Review

J. Samra, S. Sahni, A. Mittal, 2023, Cancers.