P. Ponka

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Inhibition of heme oxygenase ameliorates anemia and reduces iron overload in a β-thalassemia mouse model.

D. Garcia-Santos, Amel Hamdi, Zuzana Saxova, 2018, Blood.

TIBS 1335 No . of Pages 12 Key Figure Mechanisms Involved in the Removal of ‘ Toxic Heme ’ from the Circulation

A. English, D. Garcia-Santos, P. Ponka, 2017 .

Extracellular glycine is necessary for optimal hemoglobinization of erythroid cells

D. Garcia-Santos, P. Ponka, A. Sheftel, 2017, Haematologica.

Do Mammalian Cells Really Need to Export and Import Heme?

A. English, D. Garcia-Santos, P. Ponka, 2017, Trends in biochemical sciences.

Inhibition of heme oxygenase ameliorates anemia and reduces iron overload in β-thalassemia mouse model Short Title : Thalassemia treatment by heme oxygenase inhibition

D. Garcia-Santos, Amel Hamdi, Zuzana Saxova, 2017 .

Heme oxygenase 1 is expressed in murine erythroid cells where it controls the level of regulatory heme.

D. Garcia-Santos, Monika Horváthová, P. Ponka, 2014, Blood.

Nitrogen monoxide inhibits haem synthesis in mouse reticulocytes.

P. Ponka, Marc R. Mikhael, Tariq M. Roshan, 2013, The Biochemical journal.

Erythroid Iron Metabolism

P. Ponka, A. Sheftel, 2012 .

Molecular basis of hereditary iron homeostasis defects

V. Divoky, Monika Horváthová, P. Ponka, 2010, Hematology.

Tissue-specific regulation of iron metabolism and heme synthesis: distinct control mechanisms in erythroid cells.

P. Ponka, 1997, Blood.

The transferrin receptor: role in health and disease.

C. Lok, P. Ponka, P Ponka, 1999, The international journal of biochemistry & cell biology.

Estimation of the pluripotential stem cells in bone marrow after hydroxyurea.

P. Ponka, E. Nečas, J. Neuwirt, 1979, Haematology and blood transfusion.

Iron chelation-afforded cardioprotection against chronic anthracycline cardiotoxicity: a study of salicylaldehyde isonicotinoyl hydrazone (SIH).

P. Ponka, M. Štěrba, M. Adamcová, 2007, Toxicology.

Cardioprotective Effects of a Novel Iron Chelator, Pyridoxal 2-Chlorobenzoyl Hydrazone, in the Rabbit Model of Daunorubicin-Induced Cardiotoxicity

P. Ponka, M. Štěrba, M. Adamcová, 2006, Journal of Pharmacology and Experimental Therapeutics.

Hypoxia. 5. Hypoxia and hematopoiesis.

J. Prchal, P. Ponka, D. Yoon, 2011, American journal of physiology. Cell physiology.

Human cytomegalovirus-induced host cell enlargement is iron dependent.

P. Ponka, W. Crowe, J. Russell, 2004, American journal of physiology. Cell physiology.

Transferrin receptor 1 controls systemic iron homeostasis by fine-tuning hepcidin expression to hepatocellular iron load.

H. Vali, J. Presley, D. Garcia-Santos, 2019, Blood.

Nramp1 promotes efficient macrophage recycling of iron following erythrophagocytosis in vivo

B. Andriopoulos, D. Garcia-Santos, P. Ponka, 2009, Proceedings of the National Academy of Sciences.

Activation of macrophage cytostatic effector mechanisms during acute graft-versus-host disease: release of intracellular iron and nitric oxide-mediated cytostasis.

F. P. Nestel, W. Lapp, P. Ponka, 2000, Blood.

Transferrin receptor hyperexpression in primary erythroblasts is lost on transformation by avian erythroblastosis virus.

H. Beug, Robert B. Wilson, I. Killisch, 2002, Blood.

Lysosomal proteolysis is the primary degradation pathway for cytosolic ferritin and cytosolic ferritin degradation is necessary for iron exit.

Wei Li, Yuliang Zhao, Yiye Li, 2010, Antioxidants & redox signaling.

Transferrin and iron uptake by human lymphoblastoid and K-562 cells.

A. Wilczyńska, P. Ponka, H. Schulman, 1981, Biochemical and biophysical research communications.

Direct interorganellar transfer of iron from endosome to mitochondrion.

Claire M. Brown, O. Shirihai, P. Ponka, 2006, Blood.

Mitochondrial Iron Metabolism and Sideroblastic Anemia

D. Richardson, J. Prchal, P. Ponka, 2009, Acta Haematologica.

Cardiac troponin T following repeated administration of pyridoxal isonicotinoyl hydrazone in rabbits.

V. Pelouch, P. Ponka, M. Adamcová, 2002, Physiological Research.

Intracellular kinetics of iron in reticulocytes: evidence for endosome involvement in iron targeting to mitochondria.

P. Ponka, A. Sheftel, An-Sheng Zhang, 2005, Blood.

Study of intracellular iron distribution in rabbit reticulocytes with normal and inhibited heme synthesis.

P. Ponka, J. Neuwirt, J. Borová, 1973, Biochimica et biophysica acta.

Selective Inhibition of IκBα Phosphorylation and HIV-1 LTR-Directed Gene Expression by Novel Antioxidant Compounds☆

J. Hiscott, P. Beauparlant, P. Ponka, 1997 .

Regulation of protein kinase C (PKC) expression by iron: effect of different iron compounds on PKC-beta and PKC-alpha gene expression and role of the 5'-flanking region of the PKC-beta gene in the response to ferric transferrin.

L. Obeid, Y. Hannun, P. Ponka, 1994, Blood.

Function and regulation of transferrin and ferritin.

C. Beaumont, D. Richardson, P. Ponka, 1998, Seminars in hematology.

Identification of a mechanism of iron uptake by cells which is stimulated by hydroxyl radicals generated via the iron-catalysed Haber-Weiss reaction.

D. Richardson, P. Ponka, Des R. Richardson, 1995, Biochimica et biophysica acta.

Transferrin-receptor-independent but iron-dependent proliferation of variant Chinese hamster ovary cells.

P. Ponka, H. Schulman, R. Chan, 1992, Experimental cell research.

Identification of nonferritin mitochondrial iron deposits in a mouse model of Friedreich ataxia

Lucía Gutiérrez, F. Lázaro, T. S. St. Pierre, 2012, Proceedings of the National Academy of Sciences.

Thioredoxin-interacting protein regulates the differentiation of murine erythroid precursors.

D. Garcia-Santos, P. Ponka, Marc R. Mikhael, 2015, Experimental hematology.

The mouse Char10 locus regulates severity of pyruvate kinase deficiency and susceptibility to malaria

P. Gros, G. Min-oo, P. Ponka, 2017, PloS one.

Snx3 regulates recycling of the transferrin receptor and iron assimilation.

B. Paw, H. Lodish, M. Freedman, 2013, Cell metabolism.

Effect of pyridoxal isonicotinoyl hydrazone and other hydrazones on iron release from macrophages, reticulocytes and hepatocytes.

D. Richardson, P. Ponka, H. Schulman, 1988, Biochimica et biophysica acta.

Pyridoxal Isonicotinoyl Hydrazone (PIH) and Its Analogues: A New Group of Effective Chelators

P. Ponka, H. Schulman, J. T. Edward, 1988 .

The effect of various chelating agents on the mobilization of iron from reticulocytes in the presence and absence of pyridoxal isonicotinoyl hydrazone.

A. Wilczyńska, P. Ponka, R. Grady, 1984, Biochimica et biophysica acta.

Hepcidin, the hormone of iron metabolism, is bound speciﬁcally to (cid:1) -2-macroglobulin in blood

P. Kuchel, P. Halada, P. Ponka, 2009 .

An update on iron metabolism: Summary of the Fifth International Conference on Disorders of Iron Metabolism

H. Bonkovsky, B. Bacon, A. Tavill, 1996, Hepatology.

Ferritin does not donate its iron for haem synthesis in macrophages.

P. Ponka, A. Sheftel, Marc R. Mikhael, 2010, The Biochemical journal.

Nramp1 equips macrophages for efficient iron recycling.

P. Ponka, A. Sheftel, S. Soe-Lin, 2008, Experimental hematology.

Rare causes of hereditary iron overload.

P. Ponka, 2002, Seminars in hematology.

Response to: Dietary and pharmacological factors affecting iron absorption in mice and man

Manuela M. Santos, D. Garcia-Santos, C. Fillebeen, 2016, Haematologica.

Non-heme Induction of Heme Oxygenase-1 Does Not Alter Cellular Iron Metabolism*

P. Ponka, A. Sheftel, Sangwon F. Kim, 2007, Journal of Biological Chemistry.

The iron chelator pyridoxal isonicotinoyl hydrazone (PIH) protects plasmid pUC-18 DNA against *OH-mediated strand breaks.

P. Ponka, H. Schulman, M. Hermes-Lima, 1998, Free radical biology & medicine.

involvement in iron targeting to mitochondria Intracellular kinetics of iron in reticulocytes: evidence for endosome

P. Ponka, A. Sheftel, An-Sheng Zhang, 2013 .

the iron transport pathway in erythroid cells Severe hypochromic microcytic anemia caused by a congenital defect of

V. Divoky, J. Prchal, D. Pospíšilová, 2011 .

Both Nramp1 and DMT1 are necessary for efficient macrophage iron recycling.

Guangjun Nie, P. Ponka, Marc R. Mikhael, 2009, Experimental hematology.

Use of Nramp2-transfected Chinese hamster ovary cells and reticulocytes from mk/mk mice to study iron transport mechanisms.

P. Gros, S. Gruenheid, P. Ponka, 2008, Experimental hematology.

The anemia of "haemoglobin-deficit" (hbd/hbd) mice is caused by a defect in transferrin cycling.

P. Ponka, A. Sheftel, An-Sheng Zhang, 2006, Experimental hematology.

Functional consequences of the human DMT1 (SLC11A2) mutation on protein expression and iron uptake.

V. Divoky, D. Pospíšilová, Guangjun Nie, 2005, Blood.

Severe hypochromic microcytic anemia caused by a congenital defect of the iron transport pathway in erythroid cells.

V. Divoky, J. Prchal, V. Mihál, 2004, Blood.

Ferric‐salicylaldehyde isonicotinoyl hydrazone, a synthetic iron chelate, alleviates defective iron utilization by reticulocytes of the belgrade rat

J. Hoke, P. Ponka, M. Garrick, 1991, Journal of cellular physiology.

Evidence that transferrin supports cell proliferation by supplying iron for DNA synthesis.

P. Ponka, H. Schulman, I. Webb, 1988, Experimental cell research.

A study of intracellular iron metabolism using pyridoxal isonicotinoyl hydrazone and other synthetic chelating agents.

P. Ponka, E. Nečas, J. Neuwirt, 1979, Biochimica et biophysica acta.

Mobilization of iron from reticulocytes

P. Ponka, J. Neuwirt, O. Fuchs, 1979, FEBS letters.

Control of erythroid differentiation: Possible role of the transferrin cycle

H. Beug, M. Hayman, P. Ponka, 1986, Cell.

Hepcidin, the hormone of iron metabolism, is bound specifically to alpha-2-macroglobulin in blood.

P. Kuchel, D. Richardson, Y. Suryo Rahmanto, 2009, Blood.

Distribution of iron in reticulocytes after inhibition of heme synthesis with succinylacetone: examination of the intermediates involved in iron metabolism.

D. Richardson, P. Ponka, D. Vyoral, 1996, Blood.

Overexpression of mitochondrial ferritin sensitizes cells to oxidative stress via an iron-mediated mechanism.

Zhiyong Zhang, Yiye Li, Guangjun Nie, 2009, Antioxidants & redox signaling.

Nrf2 controls iron homoeostasis in haemochromatosis and thalassaemia via Bmp6 and hepcidin

P. Klenerman, C. Willberg, J. Hughes, 2019, Nature Metabolism.

Erythroid cell mitochondria receive endosomal iron by a "kiss-and-run" mechanism.

A. Mason, Amel Hamdi, P. Ponka, 2016, Biochimica et biophysica acta.

Investigation of the role of heme oxygenase-1 in β-thalassemia pathophysiology

P. Ponka, A. Mendel', D. Santos, 2009, McGill Science Undergraduate Research Journal.

Ferric pyridoxal isonicotinoyl hydrazone can provide iron for heme synthesis in reticulocytes.

A. Wilczyńska, P. Ponka, H. Schulman, 1982, Biochimica et biophysica acta.

Regulation of heme biosynthesis: Distinct regulatory features in erythroid cells

P. Ponka, H. Schulman, 1993, Stem cells.

mediated cytostasis - graft-versus-host disease: release of intracellular iron and nitric oxide Activation of macrophage cytostatic effector mechanisms during acute

F. P. Nestel, W. Lapp, P. Ponka, 2013 .

Regulation of transferrin receptor mRNA expression. Distinct regulatory features in erythroid cells.

L. Kühn, P. Ponka, H. Schulman, 1994, European journal of biochemistry.

Transferrin receptor and ferritin levels during murine mammary gland development.

G. Shyamala, A. Wilczyńska, P. Ponka, 1989, Biochimica et biophysica acta.

Antagonistic roles of the ERK and p38 MAPK signalling pathways in globin expression, haem biosynthesis and iron uptake.

B. Paw, P. Ponka, M. Schranzhofer, 2010, The Biochemical journal.

iron metabolism with succinylacetone: examination of the intermediates involved in Distribution of iron in reticulocytes after inhibition of heme synthesis

P. Ponka, D. Vyoral, 2011 .

Distinct features of iron metabolism in erythroid cells: implications for heme synthesis regulation.

P. Ponka, H. Schulman, 1994, Advances in experimental medicine and biology.

Haem inhibits iron uptake subsequent to endocytosis of transferrin in reticulocytes.

P. Ponka, H. Schulman, J. Martínez-Medellín, 1988, The Biochemical journal.

Alternative treatment paradigm for thalassemia using iron chelators.

P. Ponka, S. Soe-Lin, M. Trudel, 2008, Experimental hematology.

Iron can boost hepcidin both ways

B. Andriopoulos, P. Ponka, 2007 .

Red blood cell degradation products modify responsiveness of erythropoietin gene to hypoxia.

P. Ponka, E. Nečas, J. Živný, 1999, Advances in experimental medicine and biology.

Regulation of heme synthesis in erythroid cells: hemin inhibits transferrin iron utilization but not protoporphyrin synthesis.

P. Ponka, H. Schulman, 1985, Blood.

Iron utilization in rabbit reticulocytes. A study using succinylacetone as an inhibitor or heme synthesis.

A. Wilczyńska, P. Ponka, H. Schulman, 1982, Biochimica et biophysica acta.

The stimulation of globin synthesis by cobalt in reticulocytes with inhibited heme synthesis.

P. Ponka, H. Schulman, 1981, Biochimica et biophysica acta.

Synthesis of new acylhydrazones as iron-chelating compounds

P. Ponka, J. T. Edward, M. Gauthier, 1988 .

Evaluation of the iron chelation potential of hydrazones of pyridoxal, salicylaldehyde and 2‐hydroxy‐1‐naphthylaldehyde using the hepatocyte in culture

D. Richardson, P. Ponka, S. Gross, 1992, Hepatology.

Mice are poor heme absorbers and do not require intestinal Hmox1 for dietary heme iron assimilation

Manuela M. Santos, D. Garcia-Santos, C. Fillebeen, 2015, Haematologica.

Ceruloplasmin Protects Injured Spinal Cord from Iron-Mediated Oxidative Damage

A. Redensek, P. Ponka, S. David, 2008, The Journal of Neuroscience.

Safety and tolerability of repeated administration of pyridoxal 2-chlorobenzoyl hydrazone in rabbits

P. Ponka, M. Štěrba, M. Adamcová, 2005, Human & experimental toxicology.

Iron-transferrin requirements and transferrin receptor expression in proliferating cells

L. Kühn, P. Ponka, H. Schulman, 1990 .

Iron overload in human disease.

P. Ponka, R. Fleming, 2012, The New England journal of medicine.

Chapter 41 – Iron

J. Eaton, P. Ponka, M. Tenenbein, 2015 .

Iron chelators of the pyridoxal isonicotinoyl hydrazone class. Relationship of the lipophilicity of the apochelator to its ability to mobilise iron from reticulocytes in vitro.

D. Richardson, P. Ponka, J. T. Edward, 1994, Canadian journal of physiology and pharmacology.

The antioxidant effects of a novel iron chelator salicylaldehyde isonicotinoyl hydrazone in the prevention of H(2)O(2) injury in adult cardiomyocytes.

P. Ponka, M. Horackova, Z. Byczko, 2000, Cardiovascular research.

Lipophilicity of analogs of pyridoxal isonicotinoyl hydrazone (PIH) determines the efflux of iron complexes and toxicity in K562 cells.

P. Ponka, J. Buss, E. Arduini, 2003, Biochemical pharmacology.

Mobilization of intracellular iron by analogs of pyridoxal isonicotinoyl hydrazone (PIH) is determined by the membrane permeability of the iron-chelator complexes.

P. Ponka, J. Buss, E. Arduini, 2002, Biochemical pharmacology.

Effective Iron Chelation following Oral Administration of an Isoniazid‐Pyridoxal Hydrazone

A. Williams, P. Ponka, J. Humphrys, 1979, British journal of haematology.

Pyridoxal isonicotinoyl hydrazone and its analogs: potential orally effective iron-chelating agents for the treatment of iron overload disease.

D. Richardson, P. Ponka, 1998, The Journal of laboratory and clinical medicine.

Partition coefficients of the iron(III) complexes of pyridoxal isonicotinoyl hydrazone and its analogs and the correlation to iron chelation efficacy

D. Richardson, P. Ponka, J. T. Edward, 1995, Biometals.

Pyridoxal isonicotinoyl hydrazone and its analogues.

P. Ponka, M. Hermes-Lima, J. Buss, 2002, Advances in experimental medicine and biology.

Prevention of postasphyxia electroretinal dysfunction with a pyridoxal hydrazone.

P. Hardy, S. Chemtob, P. Ponka, 1997, Free radical biology & medicine.

The potential of iron chelators of the pyridoxal isonicotinoyl hydrazone class as effective antiproliferative agents.

D. Richardson, P. Ponka, E. Tran, 1995, Blood.

In vitro antioxidant properties of the iron chelator pyridoxal isonicotinoyl hydrazone and some of its analogs.

P. Ponka, H. Schulman, M. Hermes-Lima, 1995, Redox report : communications in free radical research.

Effects of Combined Chelation Treatment with Pyridoxal Isonicotinoyl Hydrazone (PIH) Analogs and Deferoxamine in Hypertransfused Rats and in Iron-Loaded Rat Heart Cells Running Head: Combined PIH analog and DFO Chelation Treatment Heading: Red Cells

G. Link, P. Ponka, W. Breuer, 2017 .

iron-loaded rat heart cells hydrazone analogs and deferoxamine in hypertransfused rats and in Effects of combined chelation treatment with pyridoxal isonicotinoyl

P. Ponka, W. Breuer, Z. Cabantchik, 2013 .

Effects of combined chelation treatment with pyridoxal isonicotinoyl hydrazone analogs and deferoxamine in hypertransfused rats and in iron-loaded rat heart cells.

Z. Cabantchik, G. Link, P. Ponka, 2003, Blood.

Development of iron chelators to treat iron overload disease and their use as experimental tools to probe intracellular iron metabolism

P. Ponka, D. R. Richardson, Přemysl Poňka, 1998, American journal of hematology.

A study of the mechanism of action of pyridoxal isonicotinoyl hydrazone at the cellular level using reticulocytes loaded with non-heme 59Fe.

P. Ponka, A. Huang, 1983, Biochimica et biophysica acta.

Biliary Iron Excretion in Rats following Pyridoxal Isonicotinoyl Hydrazone

P. Ponka, E. Nečas, M. Cikrt, 1980, British journal of haematology.

Hydrolysis of pyridoxal isonicotinoyl hydrazone and its analogs.

P. Ponka, J. Buss, 2003, Biochimica et biophysica acta.

Antitumor activity of metal-chelating compound Dp44mT is mediated by formation of a redox-active copper complex that accumulates in lysosomes.

D. Richardson, P. Ponka, U. Brunk, 2011, Cancer research.

Development of high-performance liquid chromatographic determination of salicylaldehyde isonicotinoyl hydrazone in rabbit plasma and application of this method to an in vivo study.

J. Klimeš, P. Ponka, M. Štěrba, 2005, Journal of separation science.

SIH--a novel lipophilic iron chelator--protects H9c2 cardiomyoblasts from oxidative stress-induced mitochondrial injury and cell death.

W. Paulus, R. Musters, A. Versteilen, 2005, Journal of molecular and cellular cardiology.

Anthracycline toxicity to cardiomyocytes or cancer cells is differently affected by iron chelation with salicylaldehyde isonicotinoyl hydrazone

P. Ponka, M. Štěrba, M. Adamcová, 2008, British journal of pharmacology.

A class of iron chelators with a wide spectrum of potent antitumor activity that overcomes resistance to chemotherapeutics

D. Richardson, P. Ponka, Des R Richardson, 2006, Proceedings of the National Academy of Sciences.

A study of potential toxic effects after repeated 10-week administration of a new iron chelator--salicylaldehyde isonicotinoyl hydrazone (SIH) to rabbits.

P. Ponka, M. Štěrba, M. Adamcová, 2003, Acta medica.

The effect of the iron(III) chelator, desferrioxamine, on iron and transferrin uptake by the human malignant melanoma cell.

D. Richardson, P. Ponka, E. Baker, 1994, Cancer research.

HPLC determination of a novel aroylhydrazone iron chelator (o-108) in rabbit plasma and its application to a pilot pharmacokinetic study.

J. Klimeš, P. Ponka, M. Štěrba, 2006, Journal of chromatography. B, Analytical technologies in the biomedical and life sciences.

Pyridoxal Isonicotinoyl Hydrazone (PIH) and its Analogs as Protectants Against Anthracycline-Induced Cardiotoxicity

P. Ponka, M. Štěrba, M. Adamcová, 2008, Hemoglobin.

The treatment of animal models of malaria with iron chelators by use of a novel polymeric device for slow drug release.

J. Golenser, Z. Cabantchik, W. Eling, 1997, The Journal of pharmacology and experimental therapeutics.

Mode of action of iron (III) chelators as antimalarials. IV. Potentiation of desferal action by benzoyl and isonicotinoyl hydrazone derivatives.

Z. Cabantchik, P. Ponka, M. Loyevsky, 1996, The Journal of laboratory and clinical medicine.

CHAPTER 30 – Iron

P. Ponka, 2007 .

Haem synthesis and iron uptake by reticulocytes.

P. Ponka, J. Neuwirt, 1974, British journal of haematology.

Regulation of Haemoglobin Synthesis

P. Ponka, J. Neuwirt, 1977, Springer Netherlands.

Pyridoxal isonicotinoyl hydrazone analogs induce apoptosis in hematopoietic cells due to their iron-chelating properties.

C. Weber, J. Neuzil, P. Ponka, 2003, Biochemical pharmacology.

Mitochondrial iron trafficking and the integration of iron metabolism between the mitochondrion and cytosol

D. Richardson, P. Ponka, A. Sheftel, 2010, Proceedings of the National Academy of Sciences.

The long history of iron in the Universe and in health and disease.

A. Mason, P. Ponka, A. Sheftel, 2012, Biochimica et biophysica acta.

Regulation of iron entry into reticulocytes. I. Feedback inhibitory effect of heme on iron entry into reticulocytes and on heme synthesis.

P. Ponka, J. Neuwirt, 1969, Blood.

Control of iron delivery to haemoglobin in erythroid cells.

P. Ponka, J. Neuwirt, O. Fuchs, 1976, Ciba Foundation symposium.

Acquisition of iron from transferrin regulates reticulocyte heme synthesis.

P. Ponka, H. Schulman, Prem PonkaSB, 1985, The Journal of biological chemistry.

A novel iron uptake mechanism mediated by GPI‐anchored human p97.

W. Jefferies, D. Richardson, P. Ponka, 1995, The EMBO journal.

Role of nitric oxide in cellular iron metabolism

P. Ponka, Sangwon F. Kim, 2003, Biometals.

Cell Biology of Heme

P. Ponka, 1999 .

Decreased Sensitivity to Hydroxyurea and to [3H]Thymidine Suicide In the Middle of the S Phase

P. Ponka, E. Nečas, J. Neuwirt, 1981, Cell and tissue kinetics.

The role of heme in the regulation of delta-aminolevulinic acid and heme synthesis in rabbit reticulocytes.

P. Ponka, J. Neuwirt, J. Borová, 1969, European journal of biochemistry.

STUDY ON THE PROLIFERATIVE STATE OF HAEMOPOIETIC STEM CELLS (CFU)

P. Ponka, E. Nečas, J. Neuwirt, 1976, Cell and tissue kinetics.

Cellular and subcellular localization of the Nramp2 iron transporter in the intestinal brush border and regulation by dietary iron.

P. Gros, S. Gruenheid, P. Ponka, 1999, Blood.

Control of heme synthesis during Friend cell differentiation: Role of iron and transferrin

P. Ponka, H. Schulman, Jennifer D. Laskey, 1986, Journal of cellular physiology.

Tissue-Specific Regulation of Iron Metabolism and Heme Synthesis: Distinct Control Mechanisms in Erythroid Cells

P. Ponka, 1997 .

The use of exogenous -aminolaevulinic acid for the studies of the regulation of haem synthesis in rabbit reticulocytes.

P. Ponka, J. Neuwirt, J. Borová, 1973, Biochimica et biophysica acta.

The Use of Reticulocytes with High Non‐haem Iron Pool for Studies of Regulation of Haem Synthesis *

P. Ponka, J. Neuwirt, 1970, British journal of haematology.

The molecular mechanisms of the metabolism and transport of iron in normal and neoplastic cells.

D. Richardson, P. Ponka, 1997, Biochimica et biophysica acta.

Iron targeting to mitochondria in erythroid cells.

P. Ponka, A. Sheftel, A. Zhang, 2001, Biochemical Society transactions.

Cell biology of heme.

P. Ponka, 1999, The American journal of the medical sciences.

Identification of a Hypoxia Response Element in the Transferrin Receptor Gene*

C. Lok, P. Ponka, 1999, The Journal of Biological Chemistry.

compared to molecules involved in iron metabolism and hemoglobinization expression in Friend cells: characterization of frataxin expression Erythroid differentiation and protoporphyrin IX down-regulate frataxin

D. Richardson, P. Ponka, J. Greer, 2013 .

Erythroid differentiation and protoporphyrin IX down-regulate frataxin expression in Friend cells: characterization of frataxin expression compared to molecules involved in iron metabolism and hemoglobinization.

D. Richardson, P. Ponka, J. Greer, 2002, Blood.

Identification of an Erythroid Active Element in the Transferrin Receptor Gene*

C. Lok, P. Ponka, 2000, The Journal of Biological Chemistry.

Can ferritin provide iron for hemoglobin synthesis?

D. Richardson, P. Ponka, 1997, Blood.

Iron and transferrin distribution in reticulocytes incubated with heme synthesis inhibitors.

P. Ponka, J. Neuwirt, J. Borová, 1980, Biochimica et biophysica acta.

disease Iron trafficking in the mitochondrion: novel pathways revealed by

D. Richardson, P. Ponka, I. Napier, 2013 .

Iron trafficking in the mitochondrion: novel pathways revealed by disease.

D. Richardson, P. Ponka, Des R Richardson, 2005, Blood.

mechanismsofaction ofDFO in neoplasticcellsand becauserecentstudies

D. Richardson, P. Ponka, E. Baker, 2006 .

Uptake by the Human Malignant Melanoma Cell

D. Richardson, P. Ponka, E. Baker, 1994 .

S-Nitrosylation of IRP2 Regulates Its Stability via the Ubiquitin-Proteasome Pathway

S. Wing, P. Ponka, Sangwon F. Kim, 2004, Molecular and Cellular Biology.

Effects of Interferon-γ and Lipopolysaccharide on Macrophage Iron Metabolism Are Mediated by Nitric Oxide-induced Degradation of Iron Regulatory Protein 2*

P. Ponka, Sangwon F. Kim, 2000, The Journal of Biological Chemistry.

The effect of redox-related species of nitrogen monoxide on transferrin and iron uptake and cellular proliferation of erythroleukemia (K562) cells.

D. Richardson, P. Ponka, E. Nagy, 1995, Blood.

Hepcidin Bound to α2-Macroglobulin Reduces Ferroportin-1 Expression and Enhances Its Activity at Reducing Serum Iron Levels

M. Sari, D. Richardson, Y. Suryo Rahmanto, 2013, The Journal of Biological Chemistry.

Iron Levels Enhances Its Activity at Reducing Serum Reduces Ferroportin-1 Expression and-Macroglobulin 2 α Hepcidin Bound to Metabolism :

M. Sari, D. Richardson, P. Ponka, 2013 .

The effect of plasma and transferrin on the hemin inhibition of iron uptake by reticulocytes

P. Ponka, J. Neuwirt, 1972, Experientia.

Decreasing TfR1 expression reverses anemia and hepcidin suppression in β-thalassemic mice.

S. Rivella, Gui-yuan Li, N. Mohandas, 2017, Blood.

Mechanisms of Disease Iron Overload in Human Disease

P. Ponka, R. Fleming, 2012 .

The ins and outs of mitochondrial iron-loading: the metabolic defect in Friedreich’s ataxia

D. Richardson, Y. Suryo Rahmanto, P. Ponka, 2010, Journal of Molecular Medicine.

Iron metabolism: Physiology and pathophysiology

P. Ponka, 2000 .

Effect of heme on globin messenger RNA synthesis in spleen erythroid cells.

P. Ponka, J. Neuwirt, O. Fuchs, 1981, Journal of supramolecular structure and cellular biochemistry.

Characterization of the iron transporter DMT1 (NRAMP2/DCT1) in red blood cells of normal and anemic mk/mk mice.

P. Gros, P. Ponka, F. Canonne-Hergaux, 2001, Blood.

IL-12 p40 messenger RNA expression in target organs during acute graft-versus-host disease. Possible involvement of IFN-gamma.

F. P. Nestel, W. Lapp, P. Ponka, 1996, Journal of immunology.

Elucidation of the mechanism of mitochondrial iron loading in Friedreich's ataxia by analysis of a mouse mutant

D. Richardson, P. Ponka, M. Huang, 2009, Proceedings of the National Academy of Sciences.

Inherited Disorders of Brain Iron Homeostasis

P. Ponka, H. Schipper, 2009 .

Hypoxia-inducible Factor-1 Deficiency Results in Dysregulated Erythropoiesis Signaling and Iron Homeostasis in Mouse Development*

G. Semenza, J. Prchal, P. Ponka, 2006, Journal of Biological Chemistry.

Changes In Stem Cell Compartments In Mice After Hydroxyurea

P. Ponka, E. Nečas, J. Neuwirt, 1978, Cell and tissue kinetics.

The effect of heme and iron on haemoglobin A and F synthesis in human cord blood

P. Ponka, J. Neuwirt, J. Borová, 1968, FEBS letters.

Accumulation of heme in mitochondria from rabbit reticulocytes with inhibited globin synthesis.

P. Ponka, J. Neuwirt, J. Borová, 1973, Biochimica et biophysica acta.

and changes cellular iron homeostasis Overexpression of mitochondrial ferritin causes cytosolic iron depletion

Guangjun Nie, P. Ponka, A. Sheftel, 2013 .

In vivo tumor growth is inhibited by cytosolic iron deprivation caused by the expression of mitochondrial ferritin.

Guangjun Nie, K. Pantopoulos, P. Ponka, 2006, Blood.

Overexpression of mitochondrial ferritin causes cytosolic iron depletion and changes cellular iron homeostasis.

Guangjun Nie, P. Ponka, A. Sheftel, 2004, Blood.

New insights into erythropoiesis: the roles of folate, vitamin B12, and iron.

M. Koury, P. Ponka, 2004, Annual review of nutrition.

The ability of exogenous heme to restore globin synthesis in reticulocytes with impaired heme formation.

M. Sperl, P. Ponka, J. Neuwirt, 1970, Biochemical and biophysical research communications.

Problems of reduced heme synthesis in reticulocytes with impaired globin synthesis

P. Ponka, J. Neuwirt, J. Borová, 1969, Blut.

Translation of exogenous mRNA in a wheat embryo cell-free system; Effect of composition of cell-free system

P. Ponka, J. Neuwirt, O. Fuchs, 1978 .

Nrf2 controls iron homoeostasis in haemochromatosis and thalassaemia via Bmp6 and hepcidin

P. Klenerman, C. Willberg, J. Hughes, 2019, Nature Metabolism.

The iron chelator pyridoxal isonicotinoyl hydrazone (PIH) and its analogues prevent damage to 2-deoxyribose mediated by ferric iron plus ascorbate.

P. Ponka, H. Schulman, M. Hermes-Lima, 2000, Biochimica et biophysica acta.

Oxidative stress mediates toxicity of pyridoxal isonicotinoyl hydrazone analogs.

J. Neuzil, P. Ponka, J. Buss, 2004, Archives of biochemistry and biophysics.

EPR spin trapping and 2-deoxyribose degradation studies of the effect of pyridoxal isonicotinoyl hydrazone (PIH) on *OH formation by the Fenton reaction.

P. Ponka, H. Schulman, M. Hermes-Lima, 1999, Biochimica et biophysica acta.

Deoxyribose degradation catalyzed by Fe(III)-EDTA: kinetic aspects and potential usefulness for submicromolar iron measurements

K. Storey, P. Ponka, H. Schulman, 1994, Molecular and Cellular Biochemistry.

Expression of ferrochelatase mRNA in erythroid and non-erythroid cells.

P. Ponka, H. Schulman, R. Chan, 1993, The Biochemical journal.

Effects of nitrogen monoxide and carbon monoxide on molecular and cellular iron metabolism: mirror-image effector molecules that target iron.

D. Richardson, P. Ponka, R. Watts, 2003, The Biochemical journal.

S-Nitrosylation of IRP 2 Regulates Its Stability via the Ubiquitin-Proteasome Pathway

S. Wing, P. Ponka, Sangwon F. Kim, 2003 .

Control of Transferrin Receptor Expression via Nitric Oxide-mediated Modulation of Iron-regulatory Protein 2*

P. Ponka, Sangwon F. Kim, 1999, The Journal of Biological Chemistry.

29 - Effects of Nitrogen Monoxide on Cellular Iron Metabolism

D. Richardson, P. Ponka, 1996 .

Nitric Oxide Storage and Transport in Cells Are Mediated by Glutathione S-Transferase P1-1 and Multidrug Resistance Protein 1 via Dinitrosyl Iron Complexes*

D. Richardson, A. Townsend, D. Kalinowski, 2011, The Journal of Biological Chemistry.

Iron is still hot: hepcidin keeps it ablaze

P. Ponka, 2005 .

Evidence for the presence of free and protein-bound nonhemoglobin heme in rabbit reticulocytes.

P. Ponka, J. Neuwirt, J. Borová, 1972, Biochimica et biophysica acta.

Transferrin receptors and iron utilization in DMSO-inducible and -uninducible Friend erythroleukemia cells.

A. Wilczyńska, P. Ponka, H. Schulman, 1984, Experimental cell research.

Identification of a human mutation of DMT1 in a patient with microcytic anemia and iron overload.

J. Prchal, D. Pospíšilová, K. Indrák, 2005, Blood.

Iron Inactivates the RNA Polymerase NS5B and Suppresses Subgenomic Replication of Hepatitis C Virus*

M. Hentze, M. Muckenthaler, A. Koromilas, 2005, Journal of Biological Chemistry.

{alpha}-2-macroglobulin in blood Hepcidin, the hormone of iron metabolism, is bound specifically to

P. Kuchel, P. Halada, P. Ponka, 2009 .

Hepcidin, the hormone of iron metabolism, is bound specifically to -2-macroglobulin in blood

P. Kuchel, P. Halada, P. Ponka, 2009 .

Development of potential iron chelators for the treatment of Friedreich's ataxia: ligands that mobilize mitochondrial iron.

D. Richardson, P. Ponka, E. Becker, 2001, Biochimica et biophysica acta.

S-Nitrosothiols control breathing and oxygen homeostasis

P. Ponka, Sangwon F. Kim, 2002, Redox report : communications in free radical research.

Cellular iron metabolism.

P. Ponka, P Ponka, 1999, Kidney international. Supplement.

Hereditary Causes of Disturbed Iron Homeostasis in the Central Nervous System

P. Ponka, 2004, Annals of the New York Academy of Sciences.

The MCK mouse heart model of Friedreich's ataxia: Alterations in iron-regulated proteins and cardiac hypertrophy are limited by iron chelation

D. Richardson, P. Ponka, Marc R. Mikhael, 2008, Proceedings of the National Academy of Sciences.

Nitric oxide-mediated modulation of iron regulatory proteins: implication for cellular iron homeostasis.

P. Ponka, Sangwon F. Kim, 2002, Blood cells, molecules & diseases.

Erythropoiesis, Hemoglobin Synthesis, and Erythroid Mitochondrial Iron Homeostasis

M. Koury, P. Ponka, A. Sheftel, 2013 .

Nitrogen monoxide decreases iron uptake from transferrin but does not mobilise iron from prelabelled neoplastic cells.

D. Richardson, P. Ponka, V. Neumannová, 1995, Biochimica et biophysica acta.

Nitrogen monoxide (NO)-mediated iron release from cells is linked to NO-induced glutathione efflux via multidrug resistance-associated protein 1

D. Richardson, P. Ponka, C. Hawkins, 2006, Proceedings of the National Academy of Sciences of the United States of America.

Dysregulation of Iron Homeostasis in the CNS Contributes to Disease Progression in a Mouse Model of Amyotrophic Lateral Sclerosis

P. Ponka, P. Arosio, S. David, 2009, The Journal of Neuroscience.

Iron regulatory protein‐independent regulation of ferritin synthesis by nitrogen monoxide

P. Ponka, A. Sheftel, M. Schranzhofer, 2006, The FEBS journal.

Mobilization of iron from cells by hydroxyquinoline-based chelators.

P. Ponka, B. Stranix, J. Buss, 2005, Biochemical pharmacology.

Evaluation of ECG time intervals in a rabbit model of anthracycline-induced cardiomyopathy: a useful tool for assessment of cardioprotective agents.

P. Ponka, M. Štěrba, M. Adamcová, 2007, Physiological research.

The prolyl 4‐hydroxylase inhibitor ethyl‐3,4‐dihydroxybenzoate generates effective iron deficiency in cultured cells

K. Pantopoulos, P. Ponka, Guohua Chen, 2002, FEBS letters.

Commentary 1: Abnormal Mitochondrial Iron Metabolism in Friedreich Ataxia

P. Ponka, 2002 .

The role of heme in the release of iron from transferrin in reticulocytes.

P. Ponka, J. Neuwirt, J. Borová, 1974, Enzyme.

The iron metabolism of the human neuroblastoma cell: lack of relationship between the efficacy of iron chelation and the inhibition of DNA synthesis.

D. Richardson, P. Ponka, 1994, Journal of Laboratory and Clinical Medicine.

Study of daunorubicin cardiotoxicity prevention with pyridoxal isonicotinoyl hydrazone in rabbits.

P. Ponka, M. Štěrba, M. Adamcová, 2005, Pharmacological research.

Cardiac troponins following repeated administration of an iron chelator--salicylaldehyde isonicotinoyl hydrazone (SIH)--in rabbits.

P. Ponka, M. Štěrba, M. Adamcová, 2003, Acta medica.

Iron Utilization in Erythrocyte Formation and Hemoglobin Synthesis

P. Ponka, 2002 .

Letter: Mitochondrial iron overload.

P. Ponka, J. Neuwirt, 1975, New England Journal of Medicine.

It's hepcidin again, but is it the only master?

P. Ponka, A. Sheftel, 2006 .

Transferrin Receptor (CD71)

P. Ponka, 2002 .

Nitrogen monoxide-mediated control of ferritin synthesis: Implications for macrophage iron homeostasis

P. Ponka, Sangwon F. Kim, 2002, Proceedings of the National Academy of Sciences of the United States of America.

Recent advances in cellular iron metabolism

P. Ponka, 2003 .

Hepcidin, the hormone of iron metabolism, is bound specifically to alpha-2-macroglobulin in blood.

P. Kuchel, D. Richardson, Y. Suryo Rahmanto, 2009, Blood.

Lysosomal proteolysis is the primary degradation pathway for cytosolic ferritin and cytosolic ferritin degradation is necessary for iron exit.

Wei Li, Yuliang Zhao, Yiye Li, 2010, Antioxidants & redox signaling.

Selective inhibition of l kappaB alpha phosphorylation and HIV-1 LTR-directed gene expression by novel antioxidant compounds.

J. Hiscott, P. Beauparlant, P. Ponka, 1997, Virology.

D. Richardson, P. Ponka, J. Greer, 2013 .

Heme oxygenase 1 is expressed in murine erythroid cells where it controls the level of regulatory heme.

P. Ponka, A. Sheftel, M. Schranzhofer, 2014, Blood.

Effect of some cytostatics on the haemopoietic stem cells (CFUs) in blood

P. Ponka, E. Nečas, J. Neuwirt, 2004, Cancer Chemotherapy and Pharmacology.

Orally effective iron chelators for the treatment of iron overload disease: the case for a further look at pyridoxal isonicotinoyl hydrazone and its analogs.

D. Richardson, P. Ponka, 1998, The Journal of laboratory and clinical medicine.

Disappearance of haemopoietic stem cells from blood after hydroxyurea.

P. Ponka, E. Nečas, J. Neuwirt, 1978, Folia biologica.

Iron and cell proliferation: another piece of the puzzle

P. Ponka, 2004 .