J. Halperin

发表

Development of 1-((1,4-trans)-4-Aryloxycyclohexyl)-3-arylurea Activators of Heme-Regulated Inhibitor as Selective Activators of the Eukaryotic Initiation Factor 2 Alpha (eIF2α) Phosphorylation Arm of the Integrated Endoplasmic Reticulum Stress Response.

Peimin Wang, B. Hammock, C. Morisseau, 2017, Journal of medicinal chemistry.

Explorations of substituted urea functionality for the discovery of new activators of the heme-regulated inhibitor kinase.

B. Hammock, C. Morisseau, Sandeep Rana, 2013, Journal of Medicinal Chemistry.

Chemical Genetics Identify eIF2α Kinase Heme Regulated Inhibitor as Anti-Cancer Target

J. Supko, S. Denoyelle, J. Halperin, 2011, Nature chemical biology.

Small-Molecule Inhibition of the Interaction between the Translation Initiation Factors eIF4E and eIF4G

A. Degterev, Junying Yuan, G. Wagner, 2007, Cell.

Depletion of eIF2.GTP.Met-tRNAi translation initiation complex up-regulates BRCA1 expression in vitro and in vivo

J. Halperin, B. Aktas, P. Bordelois, 2015, Oncotarget.

Inhibition of Translation Initiation as a Novel Paradigm for Cancer Therapy

G. Wagner, J. Halperin, M. Chorev, 2011 .

Small-molecule targeting of translation initiation for cancer therapy

S. Singer, J. Halperin, B. Aktas, 2013, Oncotarget.

Translational Regulation of Gene Expression by ω-3 Fatty Acids

J. Halperin, H. Aktas, 2004 .

Depletion of intracellular Ca2+ stores, phosphorylation of eIF2alpha, and sustained inhibition of translation initiation mediate the anticancer effects of clotrimazole.

J. Halperin, H. Aktas, R. Flückiger, 1998, Proceedings of the National Academy of Sciences of the United States of America.

Plasma glycated CD59 (gCD59), a novel biomarker for the diagnosis, management and follow up of women with Gestational Diabetes (GDM) – protocol for prospective cohort study

J. Halperin, D. Bogdanet, P. O'Shea, 2020, BMC Pregnancy and Childbirth.

Building blocks for the synthesis of post‐translationally modified glycated peptides and proteins

A. Papini, P. Rovero, J. Halperin, 2009, Journal of peptide science : an official publication of the European Peptide Society.

Molecular basis for a link between complement and the vascular complications of diabetes.

A. Goldfine, J. Halperin, R. Flückiger, 2000, Proceedings of the National Academy of Sciences of the United States of America.

The structure of the complex between the translation initiation factor eIF 4 E with the inhibitor 4 EGI-1 reveals an allosteric mechanism for dissociating eIF 4

R. E. Luna, E. Papadopoulos, G. Wagner, 2014 .

Increased digitalis-like activity in human cerebrospinal fluid after expansion of the extracellular fluid volume.

J. Halperin, A. Martín, S. Malavé, 1985, Life sciences.

Genomic structure, functional comparison, and tissue distribution of mouse Cd59a and Cd59b

Charles Lee, C. Morton, J. Halperin, 2001, Mammalian Genome.

Synthesis and SAR study of novel 3,3-diphenyl-1,3-dihydroindol-2-one derivatives as potent eIF2·GTP·Met-tRNAiMet ternary complex inhibitors.

Ying Zhang, S. Denoyelle, J. Halperin, 2013, European journal of medicinal chemistry.

Tumor suppression by small molecule inhibitors of translation initiation

G. Wagner, Nancy Zhang, J. Supko, 2012, Oncotarget.

Effect of heparin-binding growth factors on monovalent cation transport in Balb/C 3T3 cells.

J. Halperin, R. Lobb, 1987, Biochemical and biophysical research communications.

Plasma-glycated CD59 as an early biomarker for gestational diabetes mellitus: prospective cohort study protocol

J. Halperin, S. Sen, Huseyin Aktas, 2022, BMJ Open.

The Diagnostic Accuracy of Second Trimester Plasma Glycated CD59 (pGCD59) to Identify Women with Gestational Diabetes Mellitus Based on the 75 g OGTT Using the WHO Criteria: A Prospective Study of Non-Diabetic Pregnant Women in Ireland

F. Dunne, J. Halperin, M. Luque-Fernández, 2022, Journal of clinical medicine.

Deficiency of the complement regulatory protein CD59 accelerates the development of diabetes-induced atherosclerosis in mice.

Rupam Sahoo, J. Halperin, Pamela Ghosh, 2017, Journal of diabetes and its complications.

Cell surface complement regulators moderate experimental myasthenia gravis pathology

J. Halperin, H. Kaminski, L. Kusner, 2013, Muscle & nerve.

Identification and Functional Characterization of a New Gene Encoding the Mouse Terminal Complement Inhibitor CD59

J. Halperin, Xiujun Sun, Wen-chao Song, 2000, The Journal of Immunology.

CD59 Mouse Terminal Complement Inhibitor the Characterization of a New Gene Encoding Identification and Functional

J. Halperin, Wen-chao Song, X. Qin, 2000 .

The Transient Pore Formed by Homologous Terminal Complement Complexes Functions as a Bidirectional Route for the Transport of Autocrine and Paracrine Signals across Human Cell Membranes

J. Halperin, D. Goldstein, M. Tosteson, 1996, Molecular medicine.

The utility of first trimester plasma glycated CD59 (pGCD59) in predicting gestational diabetes mellitus: A prospective study of non-diabetic pregnant women in Ireland

F. Dunne, J. Halperin, P. O’Shea, 2022, Diabetes research and clinical practice.

Glycation inactivation of the complement regulatory protein CD59: a possible role in the pathogenesis of the vascular complications of human diabetes.

A. Hays, J. Halperin, M. Chorev, 2004, Diabetes.

Transient changes in erythrocyte membrane permeability are induced by sublytic amounts of the complement membrane attack complex (C5b-9).

M. Rynkiewicz, J. Halperin, A. Nicholson-Weller, 1993, Blood.

Complement Regulator CD59 Protects Against Angiotensin II–Induced Abdominal Aortic Aneurysms in Mice

R. Bronson, Gongxiong Wu, J. Halperin, 2010, Circulation.

Mast cell histamine and cell dehydration thirst

J. Halperin, D. Goldstein, Daniel J. Goldstein, 1977, Nature.

Terminal complement complex C5b-9 stimulates mitogenesis in 3T3 cells.

J. Halperin, A. Nicholson-Weller, A. Taratuska, 1993, The Journal of clinical investigation.

Terminal Complement Complex C 5 b9 Stimulates Mitogenesis in 3 T 3 Cells

J. Halperin, A. Taratuska, Anne Nicholson-Wellert, 2022 .

The critical roles of platelet activation and reduced NO bioavailability in fatal pulmonary arterial hypertension in a murine hemolysis model.

J. Loscalzo, R. Bronson, Zhihai Peng, 2010, Blood.

Novel Biochemical Markers of Glycemia to Predict Pregnancy Outcomes in Women With Type 1 Diabetes

D. Feig, H. Murphy, E. Scott, 2021, Diabetes Care.

DAF/CD55 and Protectin/CD59 modulate adaptive immunity and disease outcome in experimental autoimmune myasthenia gravis

J. Halperin, J. Šoltys, Qin Xuebin, 2012, Journal of Neuroimmunology.

Ouabain-like activity in human cerebrospinal fluid.

J. Halperin, S. Malavé, R. Schaeffer, 1983, Proceedings of the National Academy of Sciences of the United States of America.

Prostaglandin E1 inhibits acute cell dehydration thirst

J. Halperin, D. Goldstein, D. J. Pérez, 1979, Pharmacology Biochemistry and Behavior.

Terminal complement proteins C5b-9 release basic fibroblast growth factor and platelet-derived growth factor from endothelial cells

J. Halperin, A. Nicholson-Weller, L. Benzaquen, 1994, The Journal of experimental medicine.

Effect of cephalic glucose infusion on insulin secretion

J. Halperin, J. Basabe, J. Farina, 1975, Diabetologia.

Structure-activity relationship study of 4EGI-1, small molecule eIF4E/eIF4G protein-protein interaction inhibitors.

E. Papadopoulos, G. Wagner, S. Cantel, 2014, European journal of medicinal chemistry.

Deficiency of the mouse complement regulatory protein mCd59b results in spontaneous hemolytic anemia with platelet activation and progressive male infertility.

J. Halperin, H. Aktas, X. Qin, 2003, Immunity.

Characteristics of an inhibitor of the Na+/K+ pump in human cerebrospinal fluid.

D. Tosteson, J. Riordan, J. Halperin, 1988, The Journal of biological chemistry.

Voltage-activated cation transport in human erythrocytes.

D. Tosteson, C. Brugnara, J. Halperin, 1989, The American journal of physiology.

Properties of the Na+-K+ pump in human red cells with increased number of pump sites.

D. Tosteson, J. Ingwall, C. Brugnara, 1987, The Journal of clinical investigation.

The ability of pGCD59 to predict adverse pregnancy outcomes: a prospective study of non-diabetic pregnant women in Ireland

F. Dunne, J. Halperin, M. Luque-Fernández, 2022, Acta Diabetologica.

Ca2+-activated K+ efflux limits complement-mediated lysis of human erythrocytes.

C. Brugnara, J. Halperin, A. Nicholson-Weller, 1989, The Journal of clinical investigation.

Complement induces a transient increase in membrane permeability in unlysed erythrocytes.

D. Tosteson, C. Brugnara, J. Halperin, 1988, The Journal of clinical investigation.

Membrane signaling by complement C5b-9, the membrane attack complex

J. Halperin, A. Nicholson-Weller, A. Nicholson‐Weller, 1993, Immunologic research.

Activated complement directly modifies the performance of isolated heart muscle cells from guinea pig and rat.

J. Halperin, T. Smith, H. Berger, 1993, The American journal of physiology.

Synthesis and conformational analysis of a cyclic peptide obtained via i to i+4 intramolecular side-chain to side-chain azide-alkyne 1,3-dipolar cycloaddition.

S. Cantel, M. Scrima, A. D'Ursi, 2008, The Journal of organic chemistry.

Novel arylsulfoanilide-oxindole hybrid as an anticancer agent that inhibits translation initiation.

J. Halperin, A. Natarajan, M. Chorev, 2004, Journal of medicinal chemistry.

3,3-diaryl-1,3-dihydroindol-2-ones as antiproliferatives mediated by translation initiation inhibition.

W. Christ, J. Halperin, A. Natarajan, 2004, Journal of medicinal chemistry.

3‐Substituted Indazoles as Configurationally Locked 4EGI‐1 Mimetics and Inhibitors of the eIF4E/eIF4G Interaction

G. Wagner, Rupam Sahoo, Revital Yefidoff-Freedman, 2014, ChemBioChem.

Synthesis and biological evaluation of thiazolidine-2,4-dione and 2,4-thione derivatives as inhibitors of translation initiation.

W. Christ, J. Halperin, A. Natarajan, 2004, Bioorganic & medicinal chemistry letters.

In vitro inhibition of translation initiation by N,N'-diarylureas--potential anti-cancer agents.

S. Denoyelle, J. Halperin, M. Chorev, 2012, Bioorganic & medicinal chemistry letters.

Role of Symmetry in 3,3-Diphenyl-1,3-dihydroindol-2-one Derivatives as Inhibitors of Translation Initiation.

Ying Zhang, S. Denoyelle, Jing Fan, 2022, Bioorganic & medicinal chemistry letters.

Clotrimazole inhibits cell proliferation in vitro and in vivo

C. Brugnara, J. Halperin, H. Byers, 1995, Nature Medicine.

Structure-activity requirements for the antiproliferative effect of troglitazone derivatives mediated by depletion of intracellular calcium.

W. Christ, J. Halperin, A. Natarajan, 2004, Bioorganic & medicinal chemistry letters.

Ultrahigh-resolution (1)H-(13)C HSQC spectra of metabolite mixtures using nonlinear sampling and forward maximum entropy reconstruction.

Gerhard Wagner, Sven G Hyberts, Gregory J Heffron, 2007, Journal of the American Chemical Society.

Human CD59 inhibitor sensitizes rituximab-resistant lymphoma cells to complement-mediated cytolysis.

Gongxiong Wu, Jennifer R. Brown, Zhihai Peng, 2011, Cancer research.

Voltage-activated cation permeability in high-potassium but not low-potassium red blood cells.

D. Tosteson, C. Brugnara, J. Halperin, 1990, The American journal of physiology.

Synthesis of fluorescein labeled 7-methylguanosinemonophosphate.

G. Wagner, N. Moerke, W. Christ, 2004, Bioorganic & medicinal chemistry letters.

Rapid conditional targeted ablation of cells expressing human CD59 in transgenic mice by intermedilysin

R. Bronson, Gongxiong Wu, R. Tweten, 2008, Nature Medicine.

Anticancer effects of thiazolidinediones are independent of peroxisome proliferator-activated receptor gamma and mediated by inhibition of translation initiation.

J. Halperin, R. Mortensen, H. Aktas, 2001, Cancer research.

Inhibition of Translation Initiation and Mediated by γ Peroxisome Proliferator-activated Receptor Anticancer Effects of Thiazolidinediones Are Independent of Updated

J. Halperin, R. Mortensen, H. Aktas, 2001 .

Emerging Protein Biomarkers for the Diagnosis or Prediction of Gestational Diabetes—A Scoping Review

F. Dunne, J. Halperin, P. O’Shea, 2021, Journal of clinical medicine.

Structure of the eukaryotic translation initiation factor eIF4E in complex with 4EGI-1 reveals an allosteric mechanism for dissociating eIF4G

R. E. Luna, E. Papadopoulos, G. Wagner, 2014, Proceedings of the National Academy of Sciences.

Synthesis of Rigidified eIF4E/eIF4G Inhibitor-1 (4EGI-1) Mimetic and Their in Vitro Characterization as Inhibitors of Protein–Protein Interaction

E. Papadopoulos, G. Wagner, Rupam Sahoo, 2014, Journal of medicinal chemistry.

Cancer and n–3PUFAs: The Translation Initiation Connection

J. Halperin, M. Chorev, B. Aktas, 2010 .

Mapping of the auto-inhibitory interactions of protein kinase R by nuclear magnetic resonance.

S. Hyberts, G. Wagner, D. Rovnyak, 2006, Journal of molecular biology.

Role of complement and complement regulatory proteins in the complications of diabetes.

Rupam Sahoo, J. Halperin, M. Chorev, 2015, Endocrine reviews.

Complement and Complement Regulatory Proteins in Diabetes

J. Halperin, M. Chorev, A. Vaidya, 2015 .

Complement Regulator CD59 Protects Against Atherosclerosis by Restricting the Formation of Complement Membrane Attack Complex

Gongxiong Wu, G. Sukhova, J. Halperin, 2009, Circulation research.

A possible role for complement in the pathogenesis of chronic chagasic cardiomyopathy

J. Halperin, M. de Lourdes Higuchi, M. Martins Reis, 2002, The Journal of pathology.

Generation and phenotyping of mCd59a and mCd59b double‐knockout mice

Gongxiong Wu, J. Halperin, X. Qin, 2009, American journal of hematology.

New activators of eIF2α Kinase Heme-Regulated Inhibitor (HRI) with improved biophysical properties.

A. Bohm, Revital Yefidoff-Freedman, Qingwen Zhang, 2019, European journal of medicinal chemistry.

Further Characterization of Reproductive Abnormalities in mCd59b Knockout Mice: A Potential New Function of mCd59 in Male Reproduction1

R. Bronson, J. Halperin, P. Visconti, 2005, The Journal of Immunology.

ReproductionPotential New Function of mCd59 in Male Knockout Mice: A mCd59b Abnormalities in Further Characterization of Reproductive

R. Bronson, J. Halperin, P. Visconti, 2005 .

Inhibition of translation initiation mediates the anticancer effect of the n-3 polyunsaturated fatty acid eicosapentaenoic acid.

H. Aktas, J. Halperin, A. Shahsafaei, 2000, Cancer research.

A High-Affinity Inhibitor of Human CD59 Enhances Complement-Mediated Virolysis of HIV-1: Implications for Treatment of HIV-1/AIDS

B. Shiramizu, C. Shikuma, Qigui Yu, 2009, The Journal of Immunology.

A voltage-activated cation transport pathway associated with the sodium pump.

F. Cornelius, J. Halperin, 1991, Biochimica et biophysica acta.

Complement-mediated neurotoxicity is regulated by homologous restriction

Chi-Ming Lee, J. Halperin, Yong Shen, 1995, Brain Research.

Glycation of the complement regulatory protein CD59 is a novel biomarker for glucose handling in humans.

L. Bry, N. Herring, Rupam Sahoo, 2014, The Journal of clinical endocrinology and metabolism.

A specific and sensitive assay for blood levels of glycated CD59: A novel biomarker for diabetes

L. Bry, S. Cantel, N. Herring, 2013, American journal of hematology.

Plasma Glycated CD59 Predicts Early Gestational Diabetes and Large for Gestational Age Newborns.

F. Dunne, J. Halperin, G. Desoye, 2020, The Journal of clinical endocrinology and metabolism.

Plasma Glycated CD59, a Novel Biomarker for Detection of Pregnancy-Induced Glucose Intolerance

C. Zera, E. Seely, T. McElrath, 2017, Diabetes Care.

Complement and complement regulatory proteins as potential molecular targets for vascular diseases.

J. Halperin, X. Qin, J. Acosta, 2004, Current pharmaceutical design.

HIV-1: Implications for Treatment of of Enhances Complement-Mediated Virolysis A High-Affinity Inhibitor of Human CD59

B. Shiramizu, C. Shikuma, Qigui Yu, 2013 .

Balancing role of nitric oxide in complement‐mediated activation of platelets from mCd59a and mCd59b double‐knockout mice

J. Loscalzo, Gongxiong Wu, J. Halperin, 2009, American journal of hematology.

A distinctive histidine residue is essential for in vivo glycation‐inactivation of human CD59 transgenically expressed in mice erythrocytes: Implications for human diabetes complications

Rupam Sahoo, J. Halperin, M. Chorev, 2017, American journal of hematology.

Characterization of neuronal cell death induced by complement activation.

J. Halperin, C. Lee, Y. Shen, 1997, Brain research. Brain research protocols.

CHAPTER 30 – Dietary Lipids

J. Halperin, M. Chorev, H. Aktas, 2006 .

Analysis of the promoters and 5′-UTR of mouse Cd59 genes, and of their functional activity in erythrocytes

W. Hu, J. Halperin, X. Qin, 2006, Genes and Immunity.

Synthetic studies toward aryl-(4-aryl-4H-[1,2,4]triazole-3-yl)-amine from 1,3-diarylthiourea as urea mimetics.

G. Wagner, J. Halperin, A. Natarajan, 2005, The Journal of organic chemistry.

Palytoxin induces an increase in the cation conductance of red cells

D. Tosteson, J. Halperin, M. Tosteson, 1991, The Journal of general physiology.

Paroxysmal nocturnal hemoglobinuria. A complement-mediated disease.

J. Halperin, A. Nicholson‐Weller, 1989, Complement and inflammation.

Small-molecule targeting of translation initiation for cancer therapy

S. Singer, J. Halperin, B. Aktas, 2013, Oncotarget.

Increase in mast cell number and altered vascular permeability in thirsty rats.

J. Halperin, D. J. Pérez, J. Gunst, 1978, Life sciences.

The utility of plasma glycated CD59 in predicting postpartum glucose intolerance: A prospective study of women diagnosed with GDM during a period of universal GDM screening

F. Dunne, J. Halperin, M. Luque-Fernández, 2023, Diabetic medicine : a journal of the British Diabetic Association.