A. Natarajan

发表

Development of 1-((1,4-trans)-4-Aryloxycyclohexyl)-3-arylurea Activators of Heme-Regulated Inhibitor as Selective Activators of the Eukaryotic Initiation Factor 2 Alpha (eIF2α) Phosphorylation Arm of the Integrated Endoplasmic Reticulum Stress Response.

Peimin Wang, B. Hammock, C. Morisseau, 2017, Journal of medicinal chemistry.

Explorations of substituted urea functionality for the discovery of new activators of the heme-regulated inhibitor kinase.

B. Hammock, C. Morisseau, Sandeep Rana, 2013, Journal of Medicinal Chemistry.

2,3-Substituted quinoxalin-6-amine analogs as antiproliferatives: a structure-activity relationship study.

D. Kelly, A. Natarajan, Xu Luo, 2011, Bioorganic & medicinal chemistry letters.

Cyclin Dependent Kinase 9 Inhibitors for Cancer Therapy

Sandeep Rana, Jacob I. Contreras, A. Natarajan, 2016, Journal of medicinal chemistry.

Chemical Composition of Aqueous Leaf Extract of Murraya koenigii

A. Natarajan, K. Vinodh, K. Devi, 2013 .

Hepatoprotective Activity of Boerhavia Diffusa Linn. (Nyctaginaceae) against Ibuprofen Induced Hepatotoxicity in Wistar Albino Rats

A. Natarajan, B. Senthil, A. Jayavelu, 2013 .

Isatin Derived Spirocyclic Analogues with α-Methylene-γ-butyrolactone as Anticancer Agents: A Structure-Activity Relationship Study.

Sandeep Rana, Jacob I. Contreras, A. Natarajan, 2016, Journal of medicinal chemistry.

Dimers of isatin derived α-methylene-γ-butyrolactone as potent anti-cancer agents.

T. Huxford, Sandeep Rana, A. Natarajan, 2022, Bioorganic & medicinal chemistry letters.

Spirocyclic dimer SpiD7 activates the unfolded protein response to selectively inhibit growth and induce apoptosis of cancer cells

Nicholas T. Woods, Sandeep Rana, A. Natarajan, 2022, The Journal of biological chemistry.

Micellar formulation of indocyanine green for phototherapy of melanoma.

R. Mahato, Sandeep Rana, A. Natarajan, 2015, Journal of controlled release : official journal of the Controlled Release Society.

The human AP-endonuclease 1 (APE1) is a DNA G-quadruplex structure binding protein and regulates KRAS expression in pancreatic ductal adenocarcinoma cells

P. Singh, K. Bhakat, L. Marky, 2022, Nucleic acids research.

Systemic Administration of a Brain Permeable Cdk5 Inhibitor Alters Neurobehavior

J. Bibb, E. Acosta, F. Plattner, 2022, Frontiers in Pharmacology.

RAC1 GTPase promotes the survival of breast cancer cells in response to hyper-fractionated radiation treatment

S. Batra, C. Enke, Ying Yan, 2016, Oncogene.

Chemically induced degradation of CDK9 by a proteolysis targeting chimera (PROTAC).

Sandeep Rana, Jacob I. Contreras, A. Natarajan, 2017, Chemical communications.

Impact of structurally modifying hyaluronic acid on CD44 interaction.

A. Mohs, J. Souchek, A. Natarajan, 2017, Journal of materials chemistry. B.

PIK3C3 Inhibition Promotes Sensitivity to Colon Cancer Therapy by Inhibiting Cancer Stem Cells

C. Hopkins, P. Dhawan, D. Oupický, 2021, Cancers.

Protein Kinase RNA-activated Controls Mitotic Progression and Determines Paclitaxel Chemosensitivity through B-cell lymphoma 2 in Ovarian Cancer

Tian-Li Wang, L. Yin, A. Natarajan, 2021, Oncogene.

Chemical Genetic Screens Identify Kinase Inhibitor Combinations that Target Anti-Apoptotic Proteins for Cancer Therapy.

Ayrianne J. Crawford, M. Hollingsworth, Sandeep Rana, 2018, ACS chemical biology.

Beyond the frog: the evolution of homology models of human IKKβ.

Nicholas Y. Palermo, A. Natarajan, 2011, Bioorganic & medicinal chemistry letters.

Investigation on Potential Efficacy of Methanol Extract of Lawsonia inermis L. against Carbon Tetrachloride Induced Hepatotoxicity in Wistar Albino Rats

A. Natarajan, B. S. Kumar, A. Jayavelu, 2021, International Journal of Pharmaceutical Sciences Review and Research.

PROTECTIVE POTENTIAL OF ETHANOL EXTRACT OF Annona squamosa AGAINST CISPLATIN INDUCED HEPATORENAL TOXICITY IN ALBINO RATS

A. Natarajan, B. S. Kumar, A. Jayavelu, 2015 .

Targeting the NF-κB and mTOR Pathways with a Quinoxaline Urea Analog That Inhibits IKKβ for Pancreas Cancer Therapy

M. Hollingsworth, S. Lele, A. Natarajan, 2013, Clinical Cancer Research.

Pharmacokinetics, protein binding and metabolism of a quinoxaline urea analog as an NF-κB inhibitor in mice and rats by LC-MS/MS.

A. Natarajan, N. Gautam, Y. Alnouti, 2013, Biomedical chromatography : BMC.

Selective degradation of CDK6 by a palbociclib based PROTAC.

M. Bendjennat, Sandeep Rana, A. Natarajan, 2019, Bioorganic & medicinal chemistry letters.

Characterization and Preclinical Treatment of Rotational Force-Induced Brain Injury

M. S. Mukhtar, J. Bibb, A. Sorace, 2022, bioRxiv.

Exploiting the P-1 pocket of BRCT domains toward a structure guided inhibitor design.

Nicholas Y. Palermo, Eric A. Kumar, S. J. Campbell, 2011, ACS medicinal chemistry letters.

Small molecule induced polymerization of BCL6 facilitates SIAH1 mediated degradation

Sandeep Rana, A. Natarajan, 2021, Signal Transduction and Targeted Therapy.

Small-molecule IKKβ activation modulator (IKAM) targets MAP3K1 and inhibits pancreatic tumor growth

Ayrianne J. Crawford, G. Borgstahl, M. Hollingsworth, 2022, Proceedings of the National Academy of Sciences of the United States of America.

Oncogenic Signaling by Leukemia-Associated Mutant Cbl Proteins.

G. Borgstahl, V. Band, H. Band, 2012, Biochemistry and analytical biochemistry : current research.

Mouse Pancreatic Tumor Model Independent of Tumor Suppressor Gene Inactivation.

M. Naramura, A. Natarajan, 2018, Pancreas.

Microwave-assisted cleavage of phosphate, phosphonate and phosphoramide esters

A. Natarajan, G. L. Lokesh, G. D. K. Kumar, 2006 .

Peptide truncation leads to a twist and an unusual increase in affinity for casitas B-lineage lymphoma tyrosine kinase binding domain.

Nicholas Y. Palermo, Eric A. Kumar, G. Borgstahl, 2012, Journal of medicinal chemistry.

High-throughput fluorescence polarization assay to identify inhibitors of Cbl(TKB)-protein tyrosine kinase interactions.

Eric A. Kumar, A. Natarajan, C. Charvet, 2011, Analytical biochemistry.

High throughput fluorescence polarization assay to identify inhibitors of Cbl(TKB)-PTK interactions

Eric A. Kumar, A. Natarajan, C. Charvet, 2011 .

High-throughput compatible fluorescence resonance energy transfer-based assay to identify small molecule inhibitors of AMSH deubiquitinase activity.

C. Das, A. Natarajan, S. Raja, 2013, Analytical biochemistry.

Perturbing pro-survival proteins using quinoxaline derivatives: a structure-activity relationship study.

A. Natarajan, Xu Luo, Vashti C. Bryant, 2012, Bioorganic & medicinal chemistry.

Face selective reduction of the exocyclic double bond in isatin derived spirocyclic lactones.

Sandeep Rana, A. Natarajan, 2013, Organic and biomolecular chemistry.

Novel arylsulfoanilide-oxindole hybrid as an anticancer agent that inhibits translation initiation.

J. Halperin, A. Natarajan, M. Chorev, 2004, Journal of medicinal chemistry.

3,3-diaryl-1,3-dihydroindol-2-ones as antiproliferatives mediated by translation initiation inhibition.

W. Christ, J. Halperin, A. Natarajan, 2004, Journal of medicinal chemistry.

Optimization of variables for screening solid-supported metal complexes as oxidation catalysts

A. Natarajan, J. Madalengoitia, 2000 .

Synthesis and biological evaluation of thiazolidine-2,4-dione and 2,4-thione derivatives as inhibitors of translation initiation.

W. Christ, J. Halperin, A. Natarajan, 2004, Bioorganic & medicinal chemistry letters.

Synthesis and screening of 3-substituted thioxanthen-9-one-10,10-dioxides.

A. Natarajan, S. Gilbertson, G. L. Lokesh, 2007, Bioorganic & medicinal chemistry letters.

Synthesis of unnatural amino acid derivatives via palladium catalyzed 1,4 addition of boronic acids.

A. Natarajan, D. Ray, Abijah M. Nyong, 2010, Tetrahedron letters.

Irreversible binding of an anticancer compound (BI-94) to plasma proteins

Sandeep Rana, A. Natarajan, N. Gautam, 2015, Xenobiotica; the fate of foreign compounds in biological systems.

Structure activity relationship (SAR) study identifies a quinoxaline urea analog that modulates IKKβ phosphorylation for pancreatic cancer therapy.

Sandeep Rana, Jacob I. Contreras, A. Natarajan, 2021, European journal of medicinal chemistry.

Genetic Impairment of Succinate Metabolism Disrupts Bioenergetic Sensing in Adrenal Neuroendocrine Tumor

J. Bibb, L. Meijer, A. Carter, 2022, bioRxiv.

EFFECT OF AQUEOUS FLOWER EXTRACT OF CATHARANTHUS ROSEUS ON ALLOXAN INDUCED DIABETES IN MALE ALBINO RATS

A. Natarajan, A. Sivaraj, B. S. Kumar, 2012 .

Structure-activity requirements for the antiproliferative effect of troglitazone derivatives mediated by depletion of intracellular calcium.

W. Christ, J. Halperin, A. Natarajan, 2004, Bioorganic & medicinal chemistry letters.

Inhibitors, PROTACs and Molecular Glues as Diverse Therapeutic Modalities to Target Cyclin-Dependent Kinase

Sandeep Rana, A. Natarajan, Sarbjit Singh, 2021, Cancers.

Identification of the DNA-Binding Domains of Human Replication Protein A That Recognize G-Quadruplex DNA

G. Borgstahl, M. Ouellette, L. Marky, 2011, Journal of nucleic acids.

Synthesis of fluorescein labeled 7-methylguanosinemonophosphate.

G. Wagner, N. Moerke, W. Christ, 2004, Bioorganic & medicinal chemistry letters.

EHD1 and RUSC2 Control Basal Epidermal Growth Factor Receptor Cell Surface Expression and Recycling

P. Singh, C. Guda, A. Barnekow, 2020, Molecular and Cellular Biology.

Selective killing of homologous recombination-deficient cancer cell lines by inhibitors of the RPA:RAD52 protein-protein interaction

G. Borgstahl, Sandeep Rana, J. Lovelace, 2021, PloS one.

Aminopyrazole based CDK9 PROTAC sensitizes pancreatic cancer cells to venetoclax.

Nicholas T. Woods, M. Naldrett, Sandeep Rana, 2021, Bioorganic & medicinal chemistry letters.

Symbiotic Prodrugs (SymProDs) Dual Targeting of NFkappaB and CDK.

Sandeep Rana, Jacob I. Contreras, A. Natarajan, 2020, Chemical biology & drug design.

CDK5 Inhibitor Downregulates Mcl-1 and Sensitizes Pancreatic Cancer Cell Lines to Navitoclax

Ayrianne J. Crawford, M. Hollingsworth, M. Bendjennat, 2019, Molecular Pharmacology.

Protein tyrosine kinase regulation by ubiquitination: critical roles of Cbl-family ubiquitin ligases.

Lin Dong, Nicholas Y. Palermo, G. Borgstahl, 2013, Biochimica et biophysica acta.

Anticancer activity of Celastrol in combination with ErbB2-targeted therapeutics for treatment of ErbB2-overexpressing breast cancers

Lei Duan, V. Band, H. Band, 2011, Cancer biology & therapy.

Discovery and characterization of small molecule Rac1 inhibitors

Ying Yan, M. Ouellette, A. L. Hein, 2017, Oncotarget.

A Kinase Inhibitor Screen Reveals Protein Kinase C-dependent Endocytic Recycling of ErbB2 in Breast Cancer Cells*

V. Band, H. Band, D. Kelly, 2014, The Journal of Biological Chemistry.

Small molecule adenosine 5'-monophosphate activated protein kinase (AMPK) modulators and human diseases.

Sandeep Rana, A. Natarajan, Elizabeth C Blowers, 2015, Journal of medicinal chemistry.

Fbxo7 promotes Cdk6 activity to inhibit PFKP and glycolysis in T cells

H. Laman, C. Frezza, A. Natarajan, 2021, bioRxiv.

Characterization of Promiscuous Binding of Phosphor Ligands to Breast-Cancer-Gene 1 (BRCA1) C-Terminal (BRCT): Molecular Dynamics, Free Energy, Entropy and Inhibitor Design

Wanli You, Chia-en A. Chang, Smitha Kizhake, 2016, PLoS Comput. Biol..

Small molecule binding to inhibitor of nuclear factor kappa-B kinase subunit beta in an ATP non-competitive manner.

Nicholas Y. Palermo, T. Huxford, M. Ouellette, 2021, Chemical communications.

A quinoxaline urea analog uncouples inflammatory and pro-survival functions of IKKβ.

M. Naramura, Sandeep Rana, A. Natarajan, 2015, Immunology letters.

Novel Treatment for Mantle Cell Lymphoma Including Therapy-Resistant Tumor by NF-κB and mTOR Dual-Targeting Approach

J. Vose, S. Joshi, A. Natarajan, 2013, Molecular Cancer Therapeutics.

Catalytically inactive Dnmt3b rescues mouse embryonic development by accessory and repressive functions

A. Riva, R. Opavsky, O. Guryanova, 2019, Nature Communications.

Inhibition of BRCT(BRCA1)-phosphoprotein interaction enhances the cytotoxic effect of olaparib in breast cancer cells: a proof of concept study for synthetic lethal therapeutic option

Ying Yan, A. Natarajan, T. Bessho, 2012, Breast Cancer Research and Treatment.

Human Apurinic/Apyrimidinic Endonuclease (APE1) Is Acetylated at DNA Damage Sites in Chromatin, and Acetylation Modulates Its DNA Repair Activity

Shiladitya Sengupta, K. Bhakat, A. Natarajan, 2016, Molecular and Cellular Biology.

RE SE EE DUB Proteasome Lysosome MVB / Late Endosome ESCRT Degradative Pathway EGF CblUbiquitin EGFR Associated Protiens Recycling Pathway

Nicholas Y. Palermo, G. Borgstahl, V. Band, 2012 .

Mutant Cbl proteins as oncogenic drivers in myeloproliferative disorders

V. Band, H. Band, M. Sattler, 2011, Oncotarget.

Cdk5 mediates rotational force-induced brain injury

J. Bibb, A. Sorace, D. Crossman, 2023, Scientific Reports.

A mitotic CDK5-PP4 phospho-signaling cascade primes 53BP1 for DNA repair in G1

G. Adelmant, J. Marto, K. Shah, 2019, Nature Communications.

Characterization of CDK(5) inhibitor, 20-223 (aka CP668863) for colorectal cancer therapy

M. Hollingsworth, J. Black, M. Brattain, 2017, Oncotarget.

Computational and experimental studies of the interaction between phospho-peptides and the C-terminal domain of BRCA1

Claudio N. Cavasotto, Victor M. Anisimov, Arturas Ziemys, 2011, J. Comput. Aided Mol. Des..

Synthesis and evaluation of macrocyclic diarylether heptanoid natural products and their analogs.

A. Natarajan, Vashti C. Bryant, G. D. Kishore Kumar, 2012, Bioorganic & medicinal chemistry letters.

Total synthesis of ovalifoliolatin B, acerogenins A and C

A. Natarajan, G. D. K. Kumar, 2008 .

Synthesis of aminopyrazole analogs and their evaluation as CDK inhibitors for cancer therapy.

Sandeep Rana, A. Natarajan, M. Zahid, 2018, Bioorganic & medicinal chemistry letters.

Synthesis and Evaluation of Macrocyclic Diarylether Heptanoid Natural Products and Their Analogues.

A. Natarajan, Vashti C. Bryant, G. D. K. Kumar, 2012 .

Total Synthesis of Ovalifoliolatin B (IV/V), Acerogenins A (VIIa) and C (VIIb).

A. Natarajan, G. D. K. Kumar, 2008 .

Ferulic acid dimer as a non-opioid therapeutic for acute pain

A. Natarajan, T. Berta, N. Bhuvanesh, 2018, Journal of pain research.

A study on ethnomedicinal plants of Kalavai, Vellore District, Tamil Nadu, India

A. Natarajan, B. S. Kumar, A. Jayavelu, 2013 .

The paradox of conformational constraint in the design of Cbl(TKB)-binding peptides

Eric A. Kumar, G. Borgstahl, A. Natarajan, 2013, Scientific Reports.

Dual-fluorophore quantitative high-throughput screen for inhibitors of BRCT-phosphoprotein interaction.

Sam Michael, Christopher P Austin, Anton Simeonov, 2008, Analytical biochemistry.

Structure–Activity Relationship Studies with Tetrahydroquinoline Analogs as EPAC Inhibitors

Xiaodong Cheng, A. Natarajan, J. Garrison, 2017, ACS medicinal chemistry letters.

Recent Advances in EPAC-Targeted Therapies: A Biophysical Perspective

G. Melacini, Stephen Boulton, Xiaodong Cheng, 2019, Cells.

Protein–protein interactions as therapeutic targets in neuropsychopharmacology

M. Reilly, A. Natarajan, K. Cunningham, 2009, Neuropsychopharmacology.

Synthetic studies toward aryl-(4-aryl-4H-[1,2,4]triazole-3-yl)-amine from 1,3-diarylthiourea as urea mimetics.

G. Wagner, J. Halperin, A. Natarajan, 2005, The Journal of organic chemistry.

Structure-activity relationship studies to probe the phosphoprotein binding site on the carboxy terminal domains of the breast cancer susceptibility gene 1.

Eric A. Kumar, A. Natarajan, Ziyan Yuan, 2011, Journal of medicinal chemistry.

A simple fluorescent assay for the discovery of protein-protein interaction inhibitors.

G. Borgstahl, D. Kelly, A. Natarajan, 2019, Analytical biochemistry.

Pulse design for broadband correlation NMR spectroscopy by multi-rotating frames

Paul W. Coote, N. Khaneja, G. Wagner, 2013, Journal of Biomolecular NMR.

Design, synthesis, and evaluation of a mitoxantrone probe (MXP) for biological studies

G. Borgstahl, A. Natarajan, Sarbjit Singh, 2023, bioRxiv.

Structural characterization of BRCT-tetrapeptide binding interactions.

Eric A. Kumar, K. Rajarathnam, A. Natarajan, 2010, Biochemical and biophysical research communications.

Thermodynamics of phosphopeptide tethering to BRCT: the structural minima for inhibitor design.

B. K. Muralidhara, A. Natarajan, G. L. Lokesh, 2007, Journal of the American Chemical Society.

High-throughput fluorescence polarization assay to identify small molecule inhibitors of BRCT domains of breast cancer gene 1.

A. Natarajan, A. Rachamallu, G. L. Lokesh, 2006, Analytical biochemistry.

DHODH inhibition enhances the efficacy of immune checkpoint blockade by increasing cancer cell antigen presentation

M. Hollingsworth, D. Price, Pankaj Singh, 2023, bioRxiv.

A Kinase Inhibitor Screen Reveals Protein Kinase C-dependent Endocytic Recycling of ErbB2 in Breast Cancer Cells*

V. Band, H. Band, D. Kelly, 2014, The Journal of Biological Chemistry.

GD2 and its biosynthetic enzyme GD3 synthase promote tumorigenesis in prostate cancer by regulating cancer stem cell behavior

V. Band, C. Morrissey, A. Natarajan, 2024, Scientific reports.

Cancer-associated fibroblast-derived acetate promotes pancreatic cancer development by altering polyamine metabolism via the ACSS2–SP1–SAT1 axis

B. Edil, K. Wellen, J. Souchek, 2024, Nature cell biology.

DHODH inhibition enhances the efficacy of immune checkpoint blockade by increasing cancer cell antigen presentation

A. Natarajan, Nina V. Chaika, Kamiya Mehla, 2024, eLife.

GD2 and its biosynthetic enzyme GD3 synthase promote tumorigenesis in prostate cancer by regulating cancer stem cell behavior

J. Meza, M. Rowley, V. Band, 2023, bioRxiv.

Domino Reactions Enable Zn-Mediated Direct Synthesis of Spiro-Fused 2-Oxindole-α-Methylene-γ-Butyrolactones/Lactams from Isatin Derivatives and 2-(Bromomethyl)acrylates

A. Natarajan, Prathap Reddy Mukthapuram, 2024, Molecules.