B. Aktas

发表

Development of 1-((1,4-trans)-4-Aryloxycyclohexyl)-3-arylurea Activators of Heme-Regulated Inhibitor as Selective Activators of the Eukaryotic Initiation Factor 2 Alpha (eIF2α) Phosphorylation Arm of the Integrated Endoplasmic Reticulum Stress Response.

Peimin Wang, B. Hammock, C. Morisseau, 2017, Journal of medicinal chemistry.

Explorations of substituted urea functionality for the discovery of new activators of the heme-regulated inhibitor kinase.

B. Hammock, C. Morisseau, Sandeep Rana, 2013, Journal of Medicinal Chemistry.

Chemical Genetics Identify eIF2α Kinase Heme Regulated Inhibitor as Anti-Cancer Target

J. Supko, S. Denoyelle, J. Halperin, 2011, Nature chemical biology.

Depletion of eIF2.GTP.Met-tRNAi translation initiation complex up-regulates BRCA1 expression in vitro and in vivo

J. Halperin, B. Aktas, P. Bordelois, 2015, Oncotarget.

Inhibition of Translation Initiation as a Novel Paradigm for Cancer Therapy

G. Wagner, J. Halperin, M. Chorev, 2011 .

Identification of di-substituted ureas that prevent growth of trypanosomes through inhibition of translation initiation

U. Lopes, B. Aktas, S. Schenkman, 2018, Scientific Reports.

Emerging Role for the PERK/eIF2α/ATF4 in Human Cutaneous Leishmaniasis

U. Lopes, B. Aktas, N. Fasel, 2017, Scientific Reports.

Dual Activators of Protein Kinase R (PKR) and Protein Kinase R‐Like Kinase (PERK) Identify Common and Divergent Catalytic Targets

Q. Jin, Hong Sun, M. Chorev, 2013, Chembiochem : a European journal of chemical biology.

The eIF2-alpha kinase HRI: a potential target beyond the red blood cell

N. Burwick, B. Aktas, 2017, Expert opinion on therapeutic targets.

Small-molecule targeting of translation initiation for cancer therapy

S. Singer, J. Halperin, B. Aktas, 2013, Oncotarget.

SARS-CoV-2 Infects Endothelial Cells In Vivo and In Vitro

L. Dölken, Xiao-Ming Yin, S. Ergün, 2021, Frontiers in Cellular and Infection Microbiology.

eIF2α Phosphorylation Mediates IL24-Induced Apoptosis through Inhibition of Translation

B. Aktas, Xuelin Zhong, M. Sauane, 2017, Molecular Cancer Research.

Synthesis and SAR study of novel 3,3-diphenyl-1,3-dihydroindol-2-one derivatives as potent eIF2·GTP·Met-tRNAiMet ternary complex inhibitors.

Ying Zhang, S. Denoyelle, J. Halperin, 2013, European journal of medicinal chemistry.

Tumor suppression by small molecule inhibitors of translation initiation

G. Wagner, Nancy Zhang, J. Supko, 2012, Oncotarget.

Versatile cell ablation tools and their applications to study loss of cell functions

Hongzhen Hu, S. Ergün, B. Aktas, 2019, Cellular and Molecular Life Sciences.

The eIF2α Kinase Heme-Regulated Inhibitor Protects the Host from Infection by Regulating Intracellular Pathogen Trafficking

B. Aktas, N. Shrestha, Justin C. Boucher, 2018, Infection and Immunity.

The eIF2α kinase Heme Regulated Inhibitor (HRI) protects the host from infection by regulating intracellular pathogen trafficking

B. Aktas, N. Shrestha, Justin C. Boucher, 2017, bioRxiv.

Eukaryotic Translation Initiation Factor 4A Down-Regulation Mediates Interleukin-24-Induced Apoptosis through Inhibition of Translation

B. Aktas, Xuelin Zhong, M. Sauane, 2018, Cancers.

Structure-activity relationship study of 4EGI-1, small molecule eIF4E/eIF4G protein-protein interaction inhibitors.

E. Papadopoulos, G. Wagner, S. Cantel, 2014, European journal of medicinal chemistry.

Unveiling the Role of the Integrated Endoplasmic Reticulum Stress Response in Leishmania Infection – Future Perspectives

U. Lopes, B. Aktas, N. Fasel, 2016, Front. Immunol..

Restriction of drug transport by the tumor environment

S. Ergün, B. Aktas, E. Henke, 2018, Histochemistry and Cell Biology.

The integrated endoplasmic reticulum stress response in Leishmania amazonensis macrophage infection: the role of X‐box binding protein 1 transcription factor

U. Lopes, B. Aktas, K. L. Dias-Teixeira, 2015, FASEB journal : official publication of the Federation of American Societies for Experimental Biology.

3‐Substituted Indazoles as Configurationally Locked 4EGI‐1 Mimetics and Inhibitors of the eIF4E/eIF4G Interaction

G. Wagner, Rupam Sahoo, Revital Yefidoff-Freedman, 2014, ChemBioChem.

In vitro inhibition of translation initiation by N,N'-diarylureas--potential anti-cancer agents.

S. Denoyelle, J. Halperin, M. Chorev, 2012, Bioorganic & medicinal chemistry letters.

Role of Symmetry in 3,3-Diphenyl-1,3-dihydroindol-2-one Derivatives as Inhibitors of Translation Initiation.

Ying Zhang, S. Denoyelle, Jing Fan, 2022, Bioorganic & medicinal chemistry letters.

Human CD59 inhibitor sensitizes rituximab-resistant lymphoma cells to complement-mediated cytolysis.

Gongxiong Wu, Jennifer R. Brown, Zhihai Peng, 2011, Cancer research.

Distinct fate, dynamics and niches of renal macrophages of bone marrow or embryonic origins

Hong Wang, P. Datta, Xiaofeng Yang, 2020, Nature Communications.

Structure of the eukaryotic translation initiation factor eIF4E in complex with 4EGI-1 reveals an allosteric mechanism for dissociating eIF4G

R. E. Luna, E. Papadopoulos, G. Wagner, 2014, Proceedings of the National Academy of Sciences.

Synthesis of Rigidified eIF4E/eIF4G Inhibitor-1 (4EGI-1) Mimetic and Their in Vitro Characterization as Inhibitors of Protein–Protein Interaction

E. Papadopoulos, G. Wagner, Rupam Sahoo, 2014, Journal of medicinal chemistry.

Cancer and n–3PUFAs: The Translation Initiation Connection

J. Halperin, M. Chorev, B. Aktas, 2010 .

The Best for the Most Important: Maintaining a Pristine Proteome in Stem and Progenitor Cells

S. Ergün, B. Aktas, M. Padmasekar, 2019, Stem cells international.

potentiationent hippocampal long-term Multiple components of eIF4F are required for protein

R. E. Luna, E. Papadopoulos, J. Lacaille, 2015 .

New activators of eIF2α Kinase Heme-Regulated Inhibitor (HRI) with improved biophysical properties.

A. Bohm, Revital Yefidoff-Freedman, Qingwen Zhang, 2019, European journal of medicinal chemistry.

The eIF2 Complex and eIF2α

B. Aktas, Ting Chen, 2014 .

Endothelial cell infection and dysfunction, immune activation in severe COVID-19

R. Veazey, S. Ergün, J. Kolls, 2021, Theranostics.

Embryonic Lethal Abnormal Vision-like HuR-dependent mRNA Stability Regulates Post-transcriptional Expression of Cyclin-dependent Kinase Inhibitor p27Kip1

B. Aktas, Ting Chen, X. Qin, 2010, The Journal of Biological Chemistry.

Emerging Role for the PERK/eIF2α/ATF4 in Human Cutaneous Leishmaniasis

U. Lopes, B. Aktas, N. Fasel, 2017, Scientific Reports.

Distinct fate, dynamics and niches of renal macrophages of bone marrow or embryonic origins

P. Datta, Xiaofeng Yang, B. Aktas, 2020, Nature Communications.

IL-24 Promotes Apoptosis through cAMP-Dependent PKA Pathways in Human Breast Cancer Cells

B. Aktas, S. Redenti, Xuelin Zhong, 2018, International journal of molecular sciences.

Restriction of drug transport by the tumor environment

S. Ergün, B. Aktas, E. Henke, 2018, Histochemistry and Cell Biology.

Small-molecule targeting of translation initiation for cancer therapy

S. Singer, J. Halperin, B. Aktas, 2013, Oncotarget.

Structural and Dynamical Analyses of Apo and Cap-binding eIF4E: An in silico Study

E. Papadopoulos, B. Aktas, Ziyuan Niu, 2024, bioRxiv.

Activity of the Di-Substituted Urea-Derived Compound I-17 in Leishmania In Vitro Infections

B. Aktas, L. Galluzzi, A. Diotallevi, 2024, Pathogens.

An AI-Driven Framework for Discovery of BACE1 Inhibitors for Alzheimer’s Disease

E. Papadopoulos, B. Aktas, Yuefan Deng, 2024, bioRxiv.