C. Escolano

发表

Heme-Regulated eIF2α Kinase Modulates Hepatic FGF21 and Is Activated by PPARβ/δ Deficiency

T. Quesada-López, F. Villarroya, W. Wahli, 2016, Diabetes.

Heterocycles as Inputs in MCRs : An Update

C. Escolano, R. Lavilla, Ouldouz Ghashghaei, 2021, Multicomponent Reactions towards Heterocycles.

Aryl radical cyclisation onto pyrroles: a divergent synthesis of spiropyrrolidinyloxindoles and pyrroloquinolines

C. Escolano, Keith Jones, 2000 .

Stephacidin B, the avrainvillamide dimer: a formidable synthetic challenge.

C. Escolano, 2005, Angewandte Chemie.

Aryl radical cyclisation onto pyrroles

C. Escolano, Keith Jones, 2002 .

Access to the enantiopure pyrrolobenzodiazepine (PBD) dilactam nucleus via self-disproportionation of enantiomers

E. Molins, C. Escolano, C. Arróniz, 2018 .

Pharmacological Inhibition of Soluble Epoxide Hydrolase as a New Therapy for Alzheimer’s Disease

M. Loza, J. Brea, M. Pallàs, 2020, Neurotherapeutics.

Dynamic kinetic resolution of racemic γ-aryl-δ-oxoesters. Enantioselective synthesis of 3-arylpiperidines

E. Molins, C. Escolano, J. Bosch, 2002 .

Insights into the Pharmacokinetics and In Vitro Cell-Based Studies of the Imidazoline I2 Receptor Ligand B06

M. Loza, J. Brea, M. Pallàs, 2022, International journal of molecular sciences.

Glycosylation defects, offset by PEPCK-M, drive entosis in breast carcinoma cells

F. Viñals, P. García-Rovés, J. C. Perales, 2022, Cell Death & Disease.

Syntheses of Cinacalcet: An Enantiopure Active Pharmaceutical Ingredient (API)

S. Vázquez, R. Leiva, C. Escolano, 2016, Synthesis.

Pharmacology and preclinical validation of a novel anticancer compound targeting PEPCK-M.

F. J. Luque, M. Loza, J. Brea, 2019, Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie.

An Imidazoline 2 Receptor Ligand Relaxes Mouse Aorta via Off-Target Mechanisms Resistant to Aging

M. Pallàs, C. Escolano, L. Giménez-Llort, 2022, Frontiers in Pharmacology.

Neuroprotective Effects of a Structurally New Family of High Affinity Imidazoline I2 Receptor Ligands.

C. Escolano, J. García-Sevilla, L. Callado, 2017, ACS chemical neuroscience.

Heterocycle-Based Multicomponent Reactions in Drug Discovery: From Hit Finding to Rational Design

C. Escolano, R. Lavilla, Ouldouz Ghashghaei, 2022, Biomedicines.

Chiral oxazolopiperidone lactams: versatile intermediates for the enantioselective synthesis of piperidine-containing natural products.

C. Escolano, J. Bosch, M. Amat, 2006, Chemistry.

On the configuration of (3R,8aS)-5-oxo-3-phenyl-2,3,6,7,8,8a-hexahydro-5H-oxazolo[3,2-a]pyridine

E. Molins, C. Escolano, J. Bosch, 2003 .

Enantioselective formal synthesis of (+)-dihydrocorynantheine and (-)-dihydrocorynantheol.

Maria M. M. Santos, E. Molins, C. Escolano, 2009, Journal of Organic Chemistry.

Straightforward methodology for the enantioselective synthesis of benzo[a]- and indolo[2,3-a]quinolizidines.

Maria M. M. Santos, E. Molins, V. McKee, 2007, Journal of Organic Chemistry.

Stereoselective α-amidoalkylation of phenylglycinol-derived lactams. Synthesis of enantiopure 5,6-disubstituted 2-piperidones

E. Molins, C. Escolano, J. Bosch, 2006 .

Stereoselective α-amidoalkylation reactions of phenylglycinol-derived bicyclic lactams

C. Escolano, J. Bosch, N. Llor, 2003 .

Enantioselective synthesis of piperidine, indolizidine, and quinolizidine alkaloids from a phenylglycinol-derived delta-lactam.

C. Escolano, J. Bosch, N. Llor, 2003, The Journal of organic chemistry.

Stereocontrolled Generation of Benzo[a]‐ and Indolo[2,3‐a]quinolizidines from (S)‐Tryptophanol and (S)‐(3,4‐Dimethoxyphenyl)alaninol‐Derived Lactams

Maria M. M. Santos, C. Escolano, J. Bosch, 2011 .

Alkylation of phenylglycinol-derived oxazolopiperidone lactams. Enantioselective synthesis of beta-substituted piperidines.

E. Molins, C. Escolano, J. Bosch, 2006, The Journal of organic chemistry.

Conjugate additions to phenylglycinol-derived unsaturated delta-lactams. Enantioselective synthesis of uleine alkaloids.

F. J. Luque, E. Molins, C. Escolano, 2004, The Journal of organic chemistry.

Enantioselective synthesis of 3,3-disubstituted piperidine derivatives by enolate dialkylation of phenylglycinol-derived oxazolopiperidone lactams.

E. Molins, C. Escolano, J. Bosch, 2007, The Journal of organic chemistry.

A practical procedure for the removal of the phenylethanol moiety from phenylglycinol-derived lactams

C. Escolano, C. Arróniz, J. Bosch, 2010 .

Alkylation of Phenylglycinol-Derived Oxazolopiperidone Lactams. Enantioselective Synthesis of β-Substituted Piperidines.

E. Molins, C. Escolano, J. Bosch, 2006 .

Decarbonylative radical cyclization of alpha-amino selenoesters upon electrophilic alkenes. A general method for the 6-azabicyclo[3.2.1]octane synthesis.

C. Escolano, J. Bonjoch, J. Quirante, 2002, The Journal of organic chemistry.

Facile microwave-assisted synthesis of thioformamides from isocyanides and carbon disulfide

C. Escolano, Sònia Abás, Ulrike Moens, 2017 .

Nitrile Ylides: Generation, Properties and Synthetic Applications

M. D. Duque, S. Vázquez, C. Escolano, 2007 .

Cooperative Catalysis for the First Asymmetric Formal [3+2] Cycloaddition Reaction of Isocyanoacetates to α,β‐Unsaturated Ketones

C. Escolano, C. Arróniz, J. Bosch, 2011 .

N -Substituted Nitriles and Other Heteroanalogs of Nitriles of the Type RCZ

S. Vázquez, C. Escolano, 2005 .

Synthesis of 2-azabicyclo[3.3.1]nonanes by means of (carbamoyl)dichloromethyl radical cyclization

C. Escolano, J. Bonjoch, J. Quirante, 1980 .

Synthesis and evaluation of tacrine-related compounds for the treatment of Alzheimer's disease

M. Dierssen, P. Camps, J. Baños, 1994 .

First diastereoselective [3 + 2] cycloaddition reaction of diethyl isocyanomethylphosphonate and maleimides.

F. J. Luque, E. Molins, C. Escolano, 2013, Organic & biomolecular chemistry.

Cyclization of 1-(carbamoyl)dichloromethyl radicals upon activated alkenes. A new entry to 2-azabicyclo[3.3.1]nonanes

C. Escolano, J. Bonjoch, J. Quirante, 1997 .

First Total Synthesis of (±)-Melinonine-E and (±)-Strychnoxanthine Using a Radical Cyclization Process as the Core Ring-Forming Step

C. Escolano, J. Bonjoch, J. Quirante, 1998 .

Direct reductive alkylation of amine hydrochlorides with aldehyde bisulfite adducts

S. Vázquez, C. Escolano, S. Codony, 2014 .

Synthesis of biaryls via intramolecular free radical ipso-substitution reactions

S. Vázquez, F. Ujjainwalla, C. Escolano, 2015 .

A New Method to Generate α-Aminoalkyl Radicals: Treatment of Methyl α-Amino Selenoesters with Hydride Reagents. Synthesis of 6-Azabicyclo[3.2.1]octanes by Radical Cyclization

C. Escolano, J. Bonjoch, J. Quirante, 1997 .

First total synthesis of (±)-melinonine-E

C. Escolano, J. Bonjoch, J. Bosch, 1995 .

Radical promoted cyclisations of trichloroacetamides with silyl enol ethers and enol acetates: the role of the hydride reagent [tris(trimethylsilyl)silane vs. tributylstannane]

C. Escolano, J. Bonjoch, F. Diaba, 1999 .

Bicyclic -iminophosphonates as highly affinity imidazoline I2 receptor ligands for Alzheimer's Disease.

F. J. Luque, P. Pérez-Lozano, L. Naesens, 2020, Journal of medicinal chemistry.

Running title : Formulation of Solid Triheptanoin-Rich Ketogenic Diet for Rodents Synthesis of trieheptanoin and formulation as a solid diet for rodents

I. Ferrer, J. C. Perales, A. Calpena, 2013 .

Synthesis of triheptanoin and formulation as a solid diet for rodents

I. Ferrer, J. C. Perales, A. Calpena, 2012 .

Synthesis and structural study of 6-amino-1,4,6,7-tetrahydroimidazo[4,5-b]pyridin-5-ones

C. Escolano, M. Rubiralta, A. Diez, 2002 .

Easy access to (2-imidazolin-4-yl)phosphonates by a microwave assisted multicomponent reaction

F. J. Luque, C. Estarellas, C. Escolano, 2015 .

Enantioselective, protecting group-free synthesis of 1S-ethyl-4-substituted quinolizidines.

E. Molins, C. Escolano, J. Bosch, 2012, Organic & biomolecular chemistry.

Enantioselective synthesis of cis- and trans-3,5-disubstituted piperidines. Synthesis of 20S- and 20R-dihydrocleavamine.

C. Escolano, J. Bosch, N. Llor, 2003, Organic letters.

Amelioration of BPSD-Like Phenotype and Cognitive Decline in SAMP8 Mice Model Accompanied by Molecular Changes after Treatment with I2-Imidazoline Receptor Ligand MCR5

M. Pallàs, C. Escolano, C. Griñán-Ferré, 2020, Pharmaceutics.

Microarray Analysis Revealed Inflammatory Transcriptomic Changes after LSL60101 Treatment in 5XFAD Mice Model

M. Pallàs, C. Escolano, C. Griñán-Ferré, 2021, Genes.

I2 imidazoline receptor modulation protects aged SAMP8 mice against cognitive decline by suppressing the calcineurin pathway

M. Pallàs, C. Escolano, C. Griñán-Ferré, 2020, GeroScience.

Pharmacological Inhibition of Soluble Epoxide Hydrolase as a New Therapy for Alzheimer’s Disease

M. Loza, J. Brea, M. Pallàs, 2020, Neurotherapeutics.

Pharmacological Inhibition of Soluble Epoxide Hydrolase as a New Therapy for Alzheimer’s Disease

M. Loza, J. Brea, M. Pallàs, 2019, Neurotherapeutics.

Phosphoenolpyruvate from Glycolysis and PEPCK Regulate Cancer Cell Fate by Altering Cytosolic Ca2+

P. García-Rovés, J. C. Perales, C. Escolano, 2019, Cells.

Disease‐modifying treatment with I2 imidazoline receptor ligand LSL60101 in an Alzheimer's disease mouse model: a comparative study with donepezil

M. Pallàs, C. Escolano, C. Griñán-Ferré, 2021, British journal of pharmacology.

Behavioral and Cognitive Improvement Induced by Novel Imidazoline I2 Receptor Ligands in Female SAMP8 Mice

M. Pallàs, C. Escolano, B. Pérez, 2018, Neurotherapeutics.

Triheptanoin supplementation to ketogenic diet curbs cognitive impairment in APP/PS1 mice used as a model of familial Alzheimer's disease.

I. Ferrer, J. C. Perales, A. Calpena, 2013, Current Alzheimer research.

Highly stereoselective double (R)-phenylglycinol-induced cyclocondensation reactions of symmetric aryl bis(oxoacids).

E. Molins, C. Escolano, C. Arróniz, 2011, Organic & biomolecular chemistry.

On the origin of the stereoselectivity in the alkylation of oxazolopiperidone enolates.

F. J. Luque, M. Orozco, C. Escolano, 2006, Journal of the American Chemical Society.

Sex differences in the antidepressant-like response and molecular events induced by the imidazoline-2 receptor agonist CR4056 in rats

C. Escolano, M. García-Fuster, S. Ledesma-Corvi, 2023, Pharmacology Biochemistry and Behavior.

Behavioral and Cognitive Improvement Induced by Novel Imidazoline I2 Receptor Ligands in Female SAMP8 Mice

M. Pallàs, C. Escolano, B. Pérez, 2018, Neurotherapeutics.

Discovery of Novel BRD4 Ligand Scaffolds by Automated Navigation of the Fragment Chemical Space.

X. Barril, F. von Delft, P. Filippakopoulos, 2021, Journal of medicinal chemistry.

Alkylation of phenylglycinol-derived bicyclic lactams. Enantioselective synthesis of 3-alkylpiperidines

C. Escolano, J. Bosch, N. Llor, 2005 .

Stephacidin B, the Avrainvillamide Dimer: A Formidable Synthetic Challenge

C. Escolano, 2006 .

Complete 1H and 13C NMR chemical shift assignment of N1‐ and N3‐alkylnitrohistidines and of 1,4,6,7‐tetrahydroimidazo[4,5‐b]pyridines

E. Giralt, M. Kogan, C. Escolano, 2003 .

Synthesis of enantiopure 2-azabicyclo[3.3.1]nonanes by a radical ring closure

C. Escolano, J. Bonjoch, J. Quirante, 1999 .

Asymmetric synthesis of tetracyclic substructures of Strychnos indole alkaloids

E. Molins, C. Escolano, J. Bosch, 2003 .

First asymmetric cascade reaction catalysed by chiral primary aminoalcohols.

C. Escolano, J. Bosch, M. Amat, 2011, Organic & biomolecular chemistry.

Disease‐modifying treatment with I2 imidazoline receptor ligand LSL60101 in an Alzheimer's disease mouse model: a comparative study with donepezil

M. Pallàs, C. Escolano, C. Griñán-Ferré, 2020, British journal of pharmacology.

Benzofuranyl-2-imidazoles as imidazoline I2 receptor ligands for Alzheimer's disease.

M. Loza, J. Brea, K. Nikolić, 2021, European journal of medicinal chemistry.

Synthesis, Characterization and HPLC Analysis of the (1S,2S,5R)-Diastereomer and the Enantiomer of the Clinical Candidate AR-15512

Eugènia Pujol, C. Escolano, S. Vázquez, 2021, Molecules.

Design and Synthesis of AMPK Activators and GDF15 Inducers

C. Escolano, X. Palomer, M. Vázquez-Carrera, 2023, Molecules.

Neuroprotective Effects of a Structurally New Family of High Affinity Imidazoline I2 Receptor Ligands.

C. Escolano, J. García-Sevilla, L. Callado, 2017, ACS chemical neuroscience.