P. Sinclair

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Cytochrome P450 regulation: the interplay between its heme* and apoprotein moieties in synthesis, assembly, repair, and disposal

Maria Almira Correia, P. Sinclair, F. De Matteis, 2011, Drug metabolism reviews.

A Mechanism of Oxygen Sensing in Yeast

R. O. Poyton, Li Zhang, T. Hon, 2003, Journal of Biological Chemistry.

Cytochrome P450

Benveniste, F. Durst, M. J. Coon, 1993, Handbook of Experimental Pharmacology.

Protection of the Cyp1a2(-/-) null mouse against uroporphyria and hepatic injury following exposure to 2,3,7,8-tetrachlorodibenzo-p-dioxin.

D. Nebert, P. Sinclair, T. Dalton, 2001, Toxicology and applied pharmacology.

Mutant yields and mutational spectra of the heterocyclic amines MeIQ and PhIP at the S1 locus of human-hamster AL cells with activation by chick embryo liver (CELC) co-cultures.

T. Puck, M. Shibuya, P. Sinclair, 1999, Mutation research.

Comparison of the form(s) of cytochrome P-450 induced by ethanol and glutethimide in cultured chick hepatocytes.

E. L. Smith, D. Koop, P. Sinclair, 1989, Biochemical pharmacology.

Branched electron-transport systems in bacteria.

D. White, P. Sinclair, 1971, Advances in microbial physiology.

Inhibition of protein synthesis increases the transcription of the phenobarbital-inducible CYP2H1 and CYP2H2 genes in chick embryo hepatocytes.

P. Sinclair, J. Sinclair, J. Hamilton, 1992, Archives of biochemistry and biophysics.

Induction of cytochrome P-450 and 5-aminolevulinate synthase activities in cultured rat hepatocytes.

P. Sinclair, P. Guzelian, J. Sinclair, 1990, Cancer research.

Hormonal palliation of chemoresistant ovarian cancer: three consecutive phase II trials of the Mid-Atlantic Oncology Program.

G. Wampler, P. Sinclair, J. Lokich, 1993, Journal of clinical oncology : official journal of the American Society of Clinical Oncology.

2-Amino-3,4-dimethylimidazo[4,5-f]quinoline induces and inhibits cytochrome P450 from the IA subfamily in chick and rat hepatocytes.

E. L. Smith, P. Sinclair, N. Gorman, 1992, Cancer research.

ARSENITE DECREASES CYP3A4 AND RXRα IN PRIMARY HUMAN HEPATOCYTES

S. Wrighton, R. Evans, S. Strom, 2005, Drug Metabolism and Disposition.

ARSENITE DECREASES CYP3A4 AND RXRα IN PRIMARY HUMAN HEPATOCYTES

S. Wrighton, R. Evans, S. Strom, 2005, Drug Metabolism and Disposition.

Inhibition of uroporphyrinogen decarboxylase by halogenated biphenyls in chick hepatocyte cultures. Essential role for induction of cytochrome P-448.

H. Bonkovsky, P. Sinclair, J. Sinclair, 1984, The Biochemical journal.

Uroporphyrin accumulation in cultured chick embryo hepatocytes: comparison of 2,3,7,8-tetrachlorodibenzo-p-dioxin and 3,4,3',4'-tetrachlorobiphenyl.

P. Sinclair, J. Sinclair, R. Lambrecht, 1988, Toxicology and applied pharmacology.

Role of cytochrome P450 1A2 in bilirubin degradation Studies in Cyp1a2 (-/-) mutant mice.

D. Nebert, S. Sweitzer, P. Sinclair, 2001, Biochemical pharmacology.

Ethanol-mediated increase in cytochrome P-450 in cultured hepatocytes.

E. L. Smith, P. Sinclair, J. Sinclair, 1981, Biochemical pharmacology.

CYP1A-catalyzed uroporphyrinogen oxidation in hepatic microsomes from non-mammalian vertebrates (chick and duck embryos, scup and alligator).

P. Sinclair, N. Gorman, J. Sinclair, 1998, Comparative biochemistry and physiology. Part C, Pharmacology, toxicology & endocrinology.

Identification of CYP1A5 as the CYP1A enzyme mainly responsible for uroporphyrinogen oxidation induced by AH receptor ligands in chicken liver and kidney.

P. Sinclair, N. Gorman, J. Sinclair, 1997, Drug metabolism and disposition: the biological fate of chemicals.

Multiple roles of polyhalogenated biphenyls in causing increases in cytochrome P450 and uroporphyrin accumulation in cultured hepatocytes.

P. Sinclair, J. Jacobs, N. Gorman, 1997, Toxicology and applied pharmacology.

IDENTIFICATION OF CYP 1 A 5 AS THE CYP 1 A ENZYME MAINLY RESPONSIBLE FOR UROPORPHYRINOGEN OXIDATION INDUCED BY AH RECEPTOR LIGANDS IN CHICKEN LIVER AND KIDNEY

P. Sinclair, N. Gorman, J. Sinclair, 1997 .

Ascorbic acid inhibits chemically induced uroporphyria in ascorbate‐requiring rats

P. Sinclair, N. Gorman, J. Sinclair, 1995, Hepatology.

Relationship between lucigenin-enhanced chemiluminescence and uroporphyrinogen oxidation in mouse and chick embryo liver microsomes.

G. Elder, P. Sinclair, J. Jacobs, 1990, Biochemical pharmacology.

Role of heme in phenobarbital induction of cytochromes P450 and 5-aminolevulinate synthase in cultured rat hepatocytes maintained on an extracellular matrix.

E. Schuetz, P. Sinclair, P. Guzelian, 1990, Archives of biochemistry and biophysics.

Uroporphyria caused by acetone and 5-aminolevulinic acid in iron-loaded mice.

P. Sinclair, J. Jacobs, J. Sinclair, 1989, Biochemical pharmacology.

Effect of uroporphyrin on the spectral measurement of cytochrome P450.

H. Bonkovsky, S. Shedlofsky, P. Sinclair, 1984, Biochemical pharmacology.

Improved retention of heme with increased resolution of microsomal proteins in polyacrylamide gel electrophoresis.

P. Sinclair, J. Healey, J. Sinclair, 1981, Analytical biochemistry.

Hepatic Heme Metabolism and Its Control

P. Sinclair, J. Sinclair, H. Bonkowsky, 1979, The Yale journal of biology and medicine.

Effects of iron‐EDTA on uroporphyrinogen oxidation by liver microsomes

P. Sinclair, J. Jacobs, J. Sinclair, 1989, FEBS letters.

Immunochemical detection of different isoenzymes of cytochrome P-450 induced in chick hepatocyte cultures.

H. Bonkovsky, P. Sinclair, J. Healey, 1989, The Biochemical journal.

Chlorinated biphenyls induce cytochrome P450IA2 and uroporphyrin accumulation in cultures of mouse hepatocytes.

P. Sinclair, N. Gorman, J. Sinclair, 1990, Archives of biochemistry and biophysics.

Inhibition of uroporphyrinogen decarboxylase activity. The role of cytochrome P-450-mediated uroporphyrinogen oxidation.

P. Sinclair, J. Jacobs, J. Sinclair, 1990, The Biochemical journal.

Effect of interleukin 6 on phenobarbital induction of cytochrome P-450IIB in cultured rat hepatocytes.

P. Sinclair, J. Williams, J. Sinclair, 1991, Biochemical and biophysical research communications.

Oxidation of uroporphyrinogen by methylcholanthrene-induced cytochrome P-450. Essential role of cytochrome P-450d.

J. Goldstein, P. Sinclair, J. Jacobs, 1989, The Biochemical journal.

Drug-mediated induction of cytochrome(s) P-450 and drug metabolism in cultured hepatocytes maintained in chemically defined medium.

F. Althaus, P. Sinclair, J. Sinclair, 1979, The Journal of biological chemistry.

Role of inducer binding in cytochrome P-450 IA2-mediated uroporphyrinogen oxidation.

Nicholas J. Jacobs, P. Sinclair, J. Jacobs, 1990, Journal of biochemical toxicology.

Hemopexin from four species inhibits the association of heme with cultured hepatoma cells or primary rat hepatocytes exhibiting a small number of species specific hemopexin receptors

P. Sinclair, S. Taketani, S. Immenschuh, 1998, Hepatology.

Role of mouse CYP2E1 in the O-hydroxylation of p-nitrophenol: comparison of activities in hepatic microsomes from Cyp2e1(-/-) and wild-type mice.

S. Wrighton, F. Gonzalez, E. Jeffery, 2004, Drug metabolism and disposition: the biological fate of chemicals.

Involvement of Toll-like receptor 4 in acetaminophen hepatotoxicity.

S. Wrighton, P. Sinclair, J. Hunt, 2006, American journal of physiology. Gastrointestinal and liver physiology.

Measurement of Heme Concentration

P. Sinclair, J. Jacobs, N. Gorman, 1999, Current protocols in toxicology.

Arsenite decreases CYP3A23 induction in cultured rat hepatocytes by transcriptional and translational mechanisms.

S. Wrighton, R. Evans, P. Sinclair, 2005, Toxicology and applied pharmacology.

Cyp1a1(-/-) male mice: protection against high-dose TCDD-induced lethality and wasting syndrome, and resistance to intrahepatocyte lipid accumulation and uroporphyria.

Andrew G Smith, D. Nebert, P. Sinclair, 2004, Toxicology and applied pharmacology.

Induction of cytochrome P450IA1 and its recombinant construct in H4IIE rat hepatoma cells.

E. Bresnick, P. Sinclair, L. Xu, 1993, The International journal of biochemistry.

ROLE OF THE NUCLEAR RECEPTOR PREGNANE X RECEPTOR IN ACETAMINOPHEN HEPATOTOXICITY

D. Greenblatt, S. Wrighton, R. Evans, 2005, Drug Metabolism and Disposition.

Ethanol increases cytochromes P450IIE, IIB1/2, and IIIA in cultured rat hepatocytes.

E. L. Smith, J. Schenkman, P. Sinclair, 1991, Archives of biochemistry and biophysics.

Effect of 17 alpha-ethynylestradiol on the induction of cytochrome P-450 by 3-methylcholanthrene in cultured chick embryo hepatocytes.

E. L. Smith, P. Sinclair, J. Sinclair, 1988, Biochemical pharmacology.

Avian Cytochrome P450

P. Sinclair, J. Sinclair, 1993 .

High-throughput non-heme iron assay for animal tissues.

P. Sinclair, G. Gerhard, N. Gorman, 2004, Journal of biochemical and biophysical methods.

Arsenic decreases RXRα-dependent transcription of CYP3A and suppresses immune regulators in hepatocytes.

S. Wrighton, R. Evans, S. Strom, 2012, International immunopharmacology.

High-performance liquid chromatographic separation and quantitation of tetrapyrroles from biological materials.

H. Bonkovsky, S. Howell, P. Sinclair, 1986, Analytical biochemistry.

Cobalt regulation of heme synthesis and degradation in avian embryo liver cell culture.

P. Sinclair, M. Maines, 1977, The Journal of biological chemistry.

Uroporphyria caused by ethanol in Hfe(−/−) mice as a model for porphyria cutanea tarda

G. Elder, P. Sinclair, N. Gorman, 2003, Hepatology.

Uroporphyria in Hfe mutant mice given 5‐aminolevulinate: A new model of Fe‐mediated porphyria cutanea tarda

N. Andrews, P. Sinclair, G. Gerhard, 2001, Hepatology.

Genetic factors influence ethanol‐induced uroporphyria in Hfe (—/—) mice

Nicholas J. Jacobs, G. Elder, P. Sinclair, 2004, Hepatology.

Uroporphyria in mice: Thresholds for hepatic CYP1A2 and iron

D. Nebert, P. Sinclair, T. Dalton, 2002, Hepatology.

Relative roles of CYP2E1 and CYP1A2 in mouse uroporphyria caused by acetone.

D. Nebert, F. Gonzalez, P. Sinclair, 2000, Archives of biochemistry and biophysics.

CYP1A2 is essential in murine uroporphyria caused by hexachlorobenzene and iron.

D. Nebert, P. Sinclair, T. Dalton, 2000, Toxicology and applied pharmacology.

Role of small differences in CYP1A2 in the development of uroporphyria produced by iron and 5-aminolevulinate in C57BL/6 and SWR strains of mice.

P. Sinclair, N. Gorman, J. Sinclair, 1999, Biochemical pharmacology.

Iron loading of cultured hepatocytes. Effect of iron on 5-aminolaevulinate synthase is independent of lipid peroxidation.

S. Shedlofsky, P. Sinclair, J. Sinclair, 1983, The Biochemical journal.

Dose-response relationships for the induction of P450 2B by 1,4-bis[2-(3,5-dichloropyridyloxy)]benzene (TCPOBOP) in rat and cultured rat hepatocytes

K. Dragnev, P. Thomas, R. Lubet, 1993 .

Uroporphyrin accumulation produced by halogenated biphenyls in chick-embryo hepatocytes. Reversal of the accumulation by piperonyl butoxide.

H. Bonkovsky, G. Elder, P. Sinclair, 1986, The Biochemical journal.

Formation of zinc protoporphyrin in cultured hepatocytes: effects of ferrochelatase inhibition, iron chelation or lead.

P. Sinclair, J. Jacobs, N. Gorman, 1998, Toxicology.

Effects of hemopexin on heme‐mediated repression of 5‐aminolevulinate synthase and induction of heme oxygenase in cultured hepatocytes

H. Bonkovsky, U. Muller-eberhard, P. Sinclair, 1994, Hepatology.

Effects of diphenyl ether herbicides on porphyrin accumulation by cultured hepatocytes.

Nicholas J. Jacobs, P. Sinclair, J. Jacobs, 1992, Journal of biochemical toxicology.

Biosynthesis of the farnesyl moiety of heme a from exogenous mevalonic acid by cultured chick liver cells.

S. Beale, P. Sinclair, J. Weinstein, 1986, Archives of biochemistry and biophysics.

Mechanism of the synergistic induction of CYP2H by isopentanol plus ethanol: comparison to glutethimide and relation to induction of 5-aminolevulinate synthase.

P. Sinclair, J. Sinclair, S. Wood, 1998, Archives of biochemistry and biophysics.

Isolation of four forms of acetone-induced cytochrome P-450 in chicken liver by h.p.l.c. and their enzymic characterization.

P. Sinclair, N. Gorman, J. Sinclair, 1990, The Biochemical journal.

Uroporphyrin accumulation in hepatoma cells expressing human or mouse CYP1A2: relation to the role of CYP1A2 in human porphyria cutanea tarda.

D. Nebert, P. Sinclair, T. Dalton, 2003, Biochemical pharmacology.

Uroporphyria produced in mice by iron and 5-aminolaevulinic acid does not occur in Cyp1a2(-/-) null mutant mice.

D. Nebert, P. Sinclair, T. Dalton, 1998, The Biochemical journal.

Ascorbic acid deficiency in porphyria cutanea tarda.

M. Karagas, K. Anderson, S. Shedlofsky, 1997, The Journal of laboratory and clinical medicine.

Short-term treatment with alcohols causes hepatic steatosis and enhances acetaminophen hepatotoxicity in Cyp2e1(-/-) mice.

S. Wrighton, F. Gonzalez, E. Jeffery, 2000, Toxicology and applied pharmacology.

Acetaminophen hepatotoxicity precipitated by short-term treatment of rats with ethanol and isopentanol: protection by triacetyloleandomycin.

S. Wrighton, E. Jeffery, P. Sinclair, 2000, Biochemical pharmacology.

Enhancement of 3-methylcholanthrene-mediated induction of cytochrome P-450 by 17 alpha-ethynylestradiol: immunochemical studies.

E. L. Smith, P. Sinclair, J. Sinclair, 1989, Biochemical pharmacology.

Iron increases collagenase production by rabbit synovial fibroblasts.

C. Brinckerhoff, P. Sinclair, I. Okazaki, 1981, The Journal of laboratory and clinical medicine.

Expression of 5-aminolaevulinate synthase and cytochrome P-450 mRNAs in chicken embryo hepatocytes in vivo and in culture. Effect of porphyrinogenic drugs and haem.

P. Sinclair, J. Sinclair, J. Hamilton, 1989, The Biochemical journal.

Electron Transport System of the Protoheme-requiring Anaerobe Bacteroides melaninogenicus

D. White, P. Sinclair, V. Rizza, 1968, Journal of bacteriology.

Hepatic uroporphyrin accumulation and uroporphyrinogen decarboxylase activity in cultured chick-embryo hepatocytes and in Japanese quail (Coturnix coturnix japonica) and mice treated with polyhalogenated aromatic compounds.

D. Buhler, G. Elder, P. Sinclair, 1988, The Biochemical journal.

Uroporphyrin formation induced by chlorinated hydrocarbons (lindane, polychlorinated biphenyls, tetrachlorodibenzo-p-dioxin). Requirements for endogenous iron, protein synthesis and drug-metabolizing activity.

S. Granick, P. Sinclair, 1974, Biochemical and biophysical research communications.

The transport of hemin and protoporphyrin across the plasma membrane of chick embryo liver cells in culture.

S. Granick, P. Sinclair, 1976, Annals of clinical research.

Seizure management in acute hepatic porphyria

P. Sinclair, J. Sinclair, H. Bonkowsky, 1980, Neurology.

Decreased activity of uroporphyrinogen decarboxylase caused by 2,4,5,3′,4′‐pentabromobiphenyl in chick embryo hepatocyte cultures

G. Elder, P. Sinclair, J. Sinclair, 1983, FEBS letters.

Complementary use of amperometric and spectrophotometric detection for concurrent monitoring of serum tryptophan metabolites by reversed-phase liquid chromatography.

P. Sinclair, A. Krstulović, J. Felice, 1981, Clinical chemistry.

Iron and the liver. Acute and long-term effects of iron-loading on hepatic haem metabolism.

P. Sinclair, J. Healey, J. Sinclair, 1981, The Biochemical journal.

Protoporphyrinogen accumulation in cultured hepatocytes treated with the diphenyl ether herbicide, acifluorfen.

Nicholas J. Jacobs, P. Sinclair, J. Jacobs, 1994, Cellular and molecular biology.

Effects by heme, insulin, and serum albumin on heme and protein synthesis in chick embryo liver cells cultured in a chemically defined medium, and a spectrofluorometric assay for porphyrin composition.

S. Granick, P. Sinclair, S. Sassa, 1975, The Journal of biological chemistry.

Increased glutathione in cultured hepatocytes associated with induction of cytochrome P-450. Lack of effect of glutathione depletion on induction of cytochrome P-450 and delta-aminolevulinate synthase.

H. Bonkovsky, S. Shedlofsky, P. Sinclair, 1984, Biochemical pharmacology.

Hormonal requirements for the induction of cytochrome P-450 in hepatocytes cultured in a serum-free medium.

P. Sinclair, J. Sinclair, H. Bonkowsky, 1979, Biochemical and biophysical research communications.

Effect of sodium arsenite on heme metabolism in cultured chick embryo hepatocytes.

P. Sinclair, J. Jacobs, J. Sinclair, 1999, Archives of biochemistry and biophysics.

On the functions of the yeast COX10 and COX11 gene products.

P. Sinclair, N. Gorman, A. Tzagoloff, 1993, Biochemistry and molecular biology international.

Mechanism of arsenite-mediated decreases in CYP3A23 in rat hepatocytes.

S. Wrighton, P. Sinclair, J. Jacobs, 2005, Biochemical and biophysical research communications.

Effect of arsenite on induction of CYP1A and CYP2H in primary cultures of chick hepatocytes.

P. Sinclair, J. Jacobs, J. Sinclair, 1998, Toxicology and applied pharmacology.

Effect of serum proteins on haem uptake and metabolism in primary cultures of liver cells.

A. Wolkoff, U. Muller-eberhard, P. Sinclair, 1988, The Biochemical journal.

Induction of 5-aminolaevulinate synthase by two- to five-carbon alcohols in cultured chick-embryo hepatocytes. Relationship to induction of cytochrome P-450.

H. Bonkovsky, E. L. Smith, S. Howell, 1986, The Biochemical journal.

Conversion of 5-aminolaevulinate into haem by liver homogenates. Comparison of rat and chick embryo.

P. Sinclair, J. Healey, J. Sinclair, 1981, The Biochemical journal.

Two methods for determining the activity of delta-aminolevulinate synthetase within intact liver cells in culture.

S. Granick, P. Sinclair, 1977, Analytical biochemistry.

Heme regulates hepatic 5-aminolevulinate synthase mRNA expression by decreasing mRNA half-life and not by altering its rate of transcription.

P. Sinclair, J. Sinclair, J. Hamilton, 1991, Archives of biochemistry and biophysics.

Role of Cytochrome P‐450 in Porphyria Caused by Halogenated Aromatic Compounds a

H. Bonkovsky, P. Sinclair, J. Sinclair, 1987, Annals of the New York Academy of Sciences.

Alcohol-mediated increases in acetaminophen hepatotoxicity: role of CYP2E and CYP3A.

S. Wrighton, E. Jeffery, P. Sinclair, 1998, Biochemical pharmacology.

Protection of ethanol-mediated acetaminophen hepatotoxicity by triacetyloleandomycin, a specific inhibitor of CYP3A.

S. Wrighton, E. Jeffery, P. Sinclair, 1997, Annals of clinical and laboratory science.

Acute hepatotoxicity of acetaminophen in rats treated with ethanol plus isopentanol.

E. Jeffery, P. Sinclair, J. Sinclair, 1995, Biochemical pharmacology.

Uroporphyria produced in mice by 20-methylcholanthrene and 5-aminolaevulinic acid.

G. Elder, P. Sinclair, A. Roberts, 1988, The Biochemical journal.

Formation of cobalt protoporphyrin by chicken hepatocytes in culture. Relationship to decrease of 5-aminolaevulinate synthase caused by cobalt.

P. Sinclair, F. De Matteis, J. Sinclair, 1982, Biochemical pharmacology.

Hexachlorobenzene stimulates uroporphyria in low affinity AHR mice without increasing CYP1A2.

Andrew G Smith, S. Robinson, P. Sinclair, 2007, Toxicology and applied pharmacology.

Evidence for cytochrome P450-mediated oxidation of uroporphyrinogen by cell-free liver extracts from chick embryos treated with 3-methylcholanthrene.

P. Sinclair, J. Sinclair, R. Lambrecht, 1987, Biochemical and biophysical research communications.

Effect of an oral iron chelator or iron‐deficient diets on uroporphyria in a murine model of porphyria cutanea tarda

Nicholas J. Jacobs, P. Sinclair, J. Jacobs, 2007, Hepatology.

Induction of cytochrome P4503A by taxol in primary cultures of human hepatocytes.

S. Wrighton, S. Strom, E. Schuetz, 1998, Archives of biochemistry and biophysics.

Metabolism of hepatic haem and 'green pigments' in rats given 2-allyl-2-isopropylacetamide and ferric citrate. A new model for hepatic haem turnover.

P. Sinclair, J. Healey, R. Erny, 1980, The Biochemical journal.

KINETICS OF HEPATIC HEME TURNOVER IN RATS GIVEN ALLYLISOPROPYLACETAMIDE: A NEW MODEL FOR LIVER HEME CATABOLISM

P. Sinclair, J. Healey, J. Sinclair, 1980 .

Effect of Nitrate, Fumarate, and Oxygen on the Formation of the Membrane-Bound Electron Transport System of Haemophilus parainfluenzae

D. White, P. Sinclair, 1970, Journal of bacteriology.

Effect of arsenite on the induction of CYP1A4 and CYP1A5 in cultured chick embryo hepatocytes.

P. Sinclair, J. Jacobs, N. Gorman, 2000, Toxicology and applied pharmacology.

Oxidation and reduction of membrane-bound cytochrome c in Hemophilus parainfluenzae. Reaction with oxygen, hydrogen peroxide and nitrate.

D. White, L. Smith, P. Sinclair, 1976, Biochimica et biophysica acta.

Rapid reactions of cytochromes of Hemophilus parainfluenzae on addition of substrates or oxygen.

B. Chance, D. White, L. Smith, 1970, The Journal of biological chemistry.

Increases in cytochrome p-450 in cultured hepatocytes mediated by 3- and 4-carbon alcohols.

L. Smith, P. Sinclair, J. Sinclair, 1982, Biochemical pharmacology.

Effect of arsenite on induction of CYP1A, CYP2B, and CYP3A in primary cultures of rat hepatocytes.

S. Wrighton, P. Sinclair, J. Jacobs, 1999, Toxicology and applied pharmacology.

Effect of insulin and glucagon on accumulation of uroporphyrin and coproporphyrin from 5-aminolevulinate in hepatocyte cultures.

Nicholas J. Jacobs, P. Sinclair, J. Jacobs, 2005, Archives of biochemistry and biophysics.

Effect of Taxol on cytochrome P450 3A and acetaminophen toxicity in cultured rat hepatocytes: comparison to dexamethasone.

S. Wrighton, P. Sinclair, L. Lewis, 1997, Toxicology and applied pharmacology.

Synergistic induction of cytochrome P450 by ethanol and isopentanol in cultures of chick embryo and rat hepatocytes.

E. L. Smith, P. Sinclair, J. Sinclair, 1993, Toxicology and applied pharmacology.

Pharmacodynamics of cytochrome P450 2B induction by phenobarbital, 5-ethyl-5-phenylhydantoin, and 5-ethyl-5-phenyloxazolidinedione in the male rat liver or in cultured rat hepatocytes.

P. Thomas, R. Lubet, P. Sinclair, 1993, Chemical research in toxicology.

Aminopyrine and biphenyl metabolism in cultured hepatocytes. Induction by alcohols.

E. L. Smith, P. Sinclair, J. Sinclair, 1984, Biochemical pharmacology.

Detection and localization of 3,3',4,4'-tetrachlorobiphenyl-induced P4501A protein in avian primary immune tissues.

S. Bloom, P. Sinclair, J. Sinclair, 1994, International journal of immunopharmacology.

Synergistic increases in rat hepatic cytochrome P450s by ethanol and isopentanol.

P. Sinclair, J. Sinclair, S. Wood, 1994, The Journal of pharmacology and experimental therapeutics.

Iron and the liver: acute effects of iron-loading on hepatic heme synthesis of rats. Role of decreased activity of 5-aminolevulinate dehydrase.

S. Shedlofsky, G. Elder, P. Sinclair, 1983, The Journal of clinical investigation.

Effect of iron and ascorbate on uroporphyria in ascorbate‐requiring mice as a model for porphyria cutanea tarda

Nicholas J. Jacobs, P. Sinclair, J. Jacobs, 2007, Hepatology.

Formation of cobalt protoporphyrin in the liver of rats. A mechanism for the inhibition of liver haem biosynthesis by inorganic cobalt.

P. Sinclair, F. De Matteis, J. Sinclair, 1979, The Biochemical journal.

COINCIDENT INDUCTION OF CYTOCHROME P450 AND PHENOL RED CONJUGATION IN CULTURED CHICK EMBRYO HEPATOCYTES: EFFECTS OF COBALTOUS AND MANGANOUS IONS

P. Sinclair, J. Sinclair, W. Bement, 1980 .

The carcinogen chromate causes DNA damage and inhibits drug-mediated induction of porphyrin accumulation and glucuronidation in chick embryo hepatocytes.

T. Hampton, P. Sinclair, J. Sinclair, 1983, Carcinogenesis.

Uroporphyrinogen oxidation catalyzed by human cytochromes P450.

U. Fuhr, P. Sinclair, N. Gorman, 1998, Drug metabolism and disposition: the biological fate of chemicals.

Mechanisms of Coupling between Angiotensin Converting Enzyme 2 and Nicotinic Acetylcholine Receptors

A. Ramanathan, R. Colwell, N. Kabbani, 2021, bioRxiv.

Haem synthesis from exogenous 5-aminolaevulinate in cultured chick-embryo hepatocytes. Effects of inducers of cytochromes P-450.

H. Bonkovsky, S. Shedlofsky, P. Sinclair, 1987, The Biochemical journal.

Ethanol and isopentanol increase CYP3A and CYP2E in primary cultures of human hepatocytes.

S. Wrighton, S. Strom, P. Sinclair, 1995, Archives of biochemistry and biophysics.

Arsenite decreases CYP3A4 and RXRalpha in primary human hepatocytes.

S. Wrighton, R. Evans, S. Strom, 2005, Drug metabolism and disposition: the biological fate of chemicals.

Role of CYP3A and CYP2E1 in Alcohol-Mediated Increases in Acetaminophen Hepatotoxicity: Comparison of Wild-Type and Cyp2e1(–/–) Mice

D. Greenblatt, S. Wrighton, F. Gonzalez, 2007, Drug Metabolism and Disposition.

Uroporphyrinogen oxidation catalyzed by reconstituted cytochrome P450IA2.

P. Sinclair, N. Gorman, J. Sinclair, 1992, Archives of biochemistry and biophysics.

Norcocaine and N-hydroxynorcocaine formation in human liver microsomes: role of cytochrome P-450 3A4.

D. Greenblatt, J. Evans, P. Sinclair, 1993, Pharmacology.

Role of CYP3A in ethanol-mediated increases in acetaminophen hepatotoxicity.

S. Wrighton, E. Jeffery, P. Sinclair, 1997, Toxicology and applied pharmacology.

Protection o f Ethanol-mediated Acetaminophen Hepatotoxicity by Triacetyloleandomycin , a Specific Inhibitor or CYP 3 A *

S. Wrighton, E. Jeffery, P. Sinclair, 2015 .

Release of Cr(III) from Cr(III) picolinate upon metabolic activation.

P. Sinclair, H. Walton, C. Kelley, 2001, Journal of hazardous materials.

Metabolism of the liver tumor promoter ethinyl estradiol by primary cultures of rat hepatocytes.

J. Yager, P. Sinclair, A. Standeven, 1990, Toxicology and applied pharmacology.

Decrease in hepatic cytochrome P-450 by cobalt. Evidence for a role of cobalt protoporphyrin.

E. L. Smith, P. Sinclair, J. Healey, 1982, The Biochemical journal.

Induction of Cytochrome P450 by Barbiturates in Chick Embryo Hepatocytes: A Quantitative Structure-Activity Analysis

C. Hansch, P. Sinclair, J. Sinclair, 1990 .

Oxidation of porphyrinogens by horseradish peroxidase and formation of a green pyrrole pigment.

Nicholas J. Jacobs, S. Duke, F. Dayan, 1996, Biochemical and biophysical research communications.

Hepatic heme and drug metabolism in rats with chronic mountain sickness.

H. Bonkovsky, U. Muller-eberhard, P. Sinclair, 1986, The American journal of physiology.

Effect of caffeine on acetaminophen hepatotoxicity in cultured hepatocytes treated with ethanol and isopentanol.

S. Wrighton, E. Jeffery, P. Sinclair, 2002, Toxicology and applied pharmacology.

Conversion of 5-aminolaevulinate into haem by homogenates of human liver. Comparison with rat and chick-embryo liver homogenates.

H. Bonkovsky, P. Sinclair, J. Healey, 1985, Biochemical Journal.

Toxicity of paracetamol in cultured chick hepatocytes treated with methotrexate.

S. Howell, P. Sinclair, J. Sinclair, 1993, European journal of pharmacology.

Heme-a, the heme prosthetic group of cytochrome c oxidase, is increased in Alzheimer's disease

Xiongwei Zhu, Mark A. Smith, P. Sinclair, 2009, Neuroscience Letters.

Formation of cytochrome P-450 containing haem or cobalt-protoporphyrin in liver homogenates of rats treated with phenobarbital and allylisopropylacetamide.

H. Bonkovsky, E. L. Smith, P. Sinclair, 1984, The Biochemical journal.

In vivo fate of hemopexin and heme-hemopexin complexes in the rat.

U. Muller-eberhard, J. Baynes, P. Sinclair, 1993, Archives of biochemistry and biophysics.