D. Stuehr

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Nitric oxide blocks cellular heme insertion into a broad range of heme proteins.

S. M. Waheed, Arnab Ghosh, Ritu Chakravarti, 2010, Free radical biology & medicine.

Calcium | Calcium Signaling: NO Synthase

Zhi‐qiang Wang, D. Stuehr, Chin-Chuan Wei, 2021, Encyclopedia of Biological Chemistry III.

Release of reactive nitrogen intermediates and reactive oxygen intermediates from mouse peritoneal macrophages. Comparison of activating cytokines and evidence for independent production.

C. Nathan, A. Ding, D. Stuehr, 1988, Journal of immunology.

Ascorbate attenuates pulmonary emphysema by inhibiting tobacco smoke and Rtp801-triggered lung protein modification and proteolysis

K. Panda, D. Stuehr, C. Rozanas, 2016, Proceedings of the National Academy of Sciences.

Hsp90 interacts with inducible NO synthase client protein in its heme‐free state and then drives heme insertion by an ATP‐dependent process

Arnab Ghosh, D. Stuehr, M. Chawla-Sarkar, 2011, FASEB journal : official publication of the Federation of American Societies for Experimental Biology.

Visualizing inducible nitric-oxide synthase in living cells with a heme-binding fluorescent inhibitor.

S. Erzurum, K. Panda, D. Stuehr, 2005, Proceedings of the National Academy of Sciences of the United States of America.

Inhibition of nitric oxide synthesis in corneas in storage media.

J. Connor, J. Hollyfield, D. Stuehr, 2004, Experimental Eye Research.

Immunohistochemical detection and Western blot analysis of nitrated protein in stored human corneal epithelium.

J. Connor, J. Hollyfield, D. Stuehr, 2005, Experimental eye research.

Nitric oxide synthases reveal a role for calmodulin in controlling electron transfer.

D. Stuehr, H. Abu-Soud, 1993, Proceedings of the National Academy of Sciences of the United States of America.

Excretory/secretory products from plerocercoids of Spirometra erinacei reduce iNOS and chemokine mRNA levels in peritoneal macrophages stimulated with cytokines and/or LPS

Y. Ohmori, D. Stuehr, T. Hamilton, 1997, Parasite immunology.

Tyrosine nitration on calmodulin enhances calcium-dependent association and activation of nitric-oxide synthase

Joseph J. Porter, R. Mehl, M. Haque, 2019, The Journal of Biological Chemistry.

Myoglobin maturation is driven by the hsp90 chaperone machinery and by soluble guanylyl cyclase

Arnab Ghosh, D. Stuehr, Yue Dai, 2019, FASEB journal : official publication of the Federation of American Societies for Experimental Biology.

Induction of nitrite/nitrate synthesis in murine macrophages by BCG infection, lymphokines, or interferon-gamma.

M. Marletta, D. Stuehr, 1987, Journal of immunology.

Regulation of sGC via hsp90, Cellular Heme, sGC Agonists, and NO: New Pathways and Clinical Perspectives.

Arnab Ghosh, D. Stuehr, 2017, Antioxidants & redox signaling.

Evidence That Light Modulates Protein Nitration in Rat Retina *

M. Miyagi, H. Sakaguchi, J. Hollyfield, 2002, Molecular & Cellular Proteomics.

Restricting the conformational freedom of the neuronal nitric-oxide synthase flavoprotein domain reveals impact on electron transfer and catalysis

M. Haque, D. Stuehr, Yue Dai, 2017, The Journal of Biological Chemistry.

Phosphorylation Controls Endothelial Nitric-oxide Synthase by Regulating Its Conformational Dynamics*

M. Haque, D. Stuehr, S. Ray, 2016, The Journal of Biological Chemistry.

Distinct conformational behaviors of four mammalian dual‐flavin reductases (cytochrome P450 reductase, methionine synthase reductase, neuronal nitric oxide synthase, endothelial nitric oxide synthase) determine their unique catalytic profiles

L. Waskell, M. Haque, D. Stuehr, 2014, The FEBS journal.

A kinetic model linking protein conformational motions, interflavin electron transfer and electron flux through a dual‐flavin enzyme – simulating the reductase activity of the endothelial and neuronal nitric oxide synthase flavoprotein domains

M. Haque, D. Stuehr, J. Tejero, 2011, The FEBS journal.

Surface Charges and Regulation of FMN to Heme Electron Transfer in Nitric-oxide Synthase*

D. Stuehr, J. Tejero, L. Hannibal, 2010, The Journal of Biological Chemistry.

Regulation of FMN subdomain interactions and function in neuronal nitric oxide synthase.

J. Zweier, Zhi‐qiang Wang, Robielyn P. Ilagan, 2009, Biochemistry.

Structural and mechanistic aspects of flavoproteins: electron transfer through the nitric oxide synthase flavoprotein domain

M. Haque, D. Stuehr, J. Tejero, 2009, The FEBS journal.

Surface Charge Interactions of the FMN Module Govern Catalysis by Nitric-oxide Synthase*

E. Getzoff, M. Haque, K. Panda, 2006, Journal of Biological Chemistry.

C-terminal Tail Residue Arg1400 Enables NADPH to Regulate Electron Transfer in Neuronal Nitric-oxide Synthase*

E. Getzoff, Manisha Sharma, K. Panda, 2005, Journal of Biological Chemistry.

The FAD-shielding Residue Phe1395 Regulates Neuronal Nitric-oxide Synthase Catalysis by Controlling NADP+ Affinity and a Conformational Equilibrium within the Flavoprotein Domain*

Manisha Sharma, Keng Zhu, G. Brudvig, 2004, Journal of Biological Chemistry.

Enzymology of Nitric Oxide Synthases

D. Stuehr, Sanjay Ghosh, 2000 .

Role of Reductase Domain Cluster 1 Acidic Residues in Neuronal Nitric-oxide Synthase

S. Ghosh, D. Stuehr, Sanjay Ghosh, 1999, The Journal of Biological Chemistry.

Nitric oxide alters hyaluronan deposition by airway smooth muscle cells

S. Erzurum, Ritu Chakravarti, D. Stuehr, 2018, PloS one.

GAPDH regulates cellular heme insertion into inducible nitric oxide synthase

Ritu Chakravarti, D. Stuehr, P. Fox, 2010, Proceedings of the National Academy of Sciences.

Macrophage and endothelial cell nitric oxide synthesis: cell-type selective inhibition by NG-aminoarginine, NG-nitroarginine and NG-methylarginine.

E. Jaffe, O. Griffith, D. Stuehr, 1990, Biochemical and biophysical research communications.

Irreversible inactivation of macrophage and brain nitric oxide synthase by L-NG-methylarginine requires NADPH-dependent hydroxylation.

O. Griffith, D. Stuehr, P. Feldman, 1993, Journal of medicinal chemistry.

Tyrosine Nitration Impairs Mammalian Aldolase A Activity*

S. Hazen, D. Stuehr, B. Levison, 2004, Molecular & Cellular Proteomics.

Nitric Oxide and Heat Shock Protein 90 Activate Soluble Guanylate Cyclase by Driving Rapid Change in Its Subunit Interactions and Heme Content*

J. Stasch, A. Papapetropoulos, Arnab Ghosh, 2014, The Journal of Biological Chemistry.

Glucose-mediated tyrosine nitration in adipocytes: targets and consequences.

M. Kinter, D. Stuehr, J. Crabb, 2009, Free radical biology & medicine.

Spectroscopic, catalytic and binding properties of Bacillus subtilis NO synthase-like protein: comparison with other bacterial and mammalian NO synthases.

J. Boucher, D. Mansuy, D. Stuehr, 2012, Journal of inorganic biochemistry.

Bacterial Nitric-oxide Synthases Operate without a Dedicated Redox Partner*

S. Lippard, E. Nudler, I. Gusarov, 2008, Journal of Biological Chemistry.

The Ferrous Dioxygen Complex of the Oxygenase Domain of Neuronal Nitric-oxide Synthase*

D. Rousseau, D. Stuehr, M. Couture, 2000, The Journal of Biological Chemistry.

Structure-function aspects in the nitric oxide synthases.

D. Stuehr, 1997, Annual review of pharmacology and toxicology.

Comparative Effects of Substrates and Pterin Cofactor on the Heme Midpoint Potential in Inducible and Neuronal Nitric Oxide Synthases

D. Stuehr, A. Presta, M. Stankovich, 1998 .

Higher blood flow and circulating NO products offset high-altitude hypoxia among Tibetans

C. Beall, N. Bryan, S. Erzurum, 2007, Proceedings of the National Academy of Sciences.

Interaction between Caveolin-1 and the Reductase Domain of Endothelial Nitric-oxide Synthase

M. Lisanti, S. Ghosh, D. Stuehr, 1998, The Journal of Biological Chemistry.

Electron Transfer, Oxygen Binding, and Nitric Oxide Feedback Inhibition in Endothelial Nitric-oxide Synthase*

D. Stuehr, A. Presta, K. Ichimori, 2000, The Journal of Biological Chemistry.

Soluble guanylyl cyclase requires heat shock protein 90 for heme insertion during maturation of the NO-active enzyme

Arnab Ghosh, D. Stuehr, 2012, Proceedings of the National Academy of Sciences.

14‐3‐3 in Thoracic Aortic Aneurysms: Identification of a Novel Autoantigen in Large Vessel Vasculitis

T. Daly, L. Svensson, Ritu Chakravarti, 2015, Arthritis & rheumatology.

Nitrosation of amines by stimulated macrophages.

S. Tannenbaum, M. Marletta, D. Stuehr, 1987, Carcinogenesis.

Proteomic method for identification of tyrosine-nitrated proteins.

D. Stuehr, J. Crabb, T. Koeck, 2004, Methods in molecular biology.

Conformational changes in nitric oxide synthases induced by chlorzoxazone and nitroindazoles: crystallographic and computational analyses of inhibitor potency.

Garrett M Morris, John A Tainer, Arthur J Olson, 2002, Biochemistry.

Inhibitory effects of a series of 7-substituted-indazoles toward nitric oxide synthases: particular potency of 1H-indazole-7-carbonitrile.

J. Boucher, D. Mansuy, F. Acher, 2008, Bioorganic & medicinal chemistry.

Structures of tetrahydrobiopterin binding-site mutants of inducible nitric oxide synthase oxygenase dimer and implicated roles of Trp457.

J. Tainer, E. Getzoff, S. Ghosh, 2001, Biochemistry.

Tetrahydrobiopterin binding to macrophage inducible nitric oxide synthase: heme spin shift and dimer stabilization by the potent pterin antagonist 4-amino-tetrahydrobiopterin.

E. Werner, B. Mayer, D. Stuehr, 1997, Biochemistry.

L-arginine and calmodulin regulation of the heme iron reactivity in neuronal nitric oxide synthase.

M. Ikeda-Saito, J. Olson, D. Stuehr, 1994, The Journal of biological chemistry.

Mutagenesis of acidic residues in the oxygenase domain of inducible nitric-oxide synthase identifies a glutamate involved in arginine binding.

B. Crane, D. Stuehr, R. Gachhui, 1997, Biochemistry.

High-level expression of mouse inducible nitric oxide synthase in Escherichia coli requires coexpression with calmodulin.

D. Stuehr, J. Zhang, H. Abu-Soud, 1996, Biochemical and biophysical research communications.

Rapid and Selective Oxygen-regulated Protein Tyrosine Denitration and Nitration in Mitochondria*

S. Hazen, D. Stuehr, J. Crabb, 2004, Journal of Biological Chemistry.

Characterization of the proximal ligand in the P420 form of inducible nitric oxide synthase.

D. Rousseau, D. Stuehr, S. Yeh, 2009, Journal of the American Chemical Society.

Ascorbate in Aqueous Humor Augments Nitric Oxide Production by Macrophages

Arnab Ghosh, D. Stuehr, Alex F. Chen, 2013, The Journal of Immunology.

Nitric Oxide Production by Macrophages Ascorbate in Aqueous Humor Augments

Arnab Ghosh, D. Stuehr, Alex F. Chen, 2012 .

NO synthase isoforms specifically modify peroxynitrite reactivity

T. Mattioli, D. Stuehr, A. Maréchal, 2010, The FEBS journal.

BYK 191023 ( 2-[ 2-( 4-Methoxy-pyridin-2-yl )-ethyl ]-3 H-imidazo [ 4 , 5b ] pyridine ) Is an NADPH-and Time-Dependent Irreversible Inhibitor of Inducible Nitric-Oxide Synthase

D. Stuehr, Mauro Tiso, R. Boer, 2008 .

BYK191023 (2-[2-(4-Methoxy-pyridin-2-yl)-ethyl]-3H-imidazo[4,5-b]pyridine) Is an NADPH- and Time-Dependent Irreversible Inhibitor of Inducible Nitric-Oxide Synthase

D. Stuehr, Mauro Tiso, R. Boer, 2008, Molecular Pharmacology.

BYK191023 Is A NADPH- And Time-Dependent Irreversible Inhibitor Of Inducible Nitric-Oxide Synthase

D. Stuehr, Mauro Tiso, R. Boer, 2007 .

Spectral characterization of brain and macrophage nitric oxide synthases. Cytochrome P-450-like hemeproteins that contain a flavin semiquinone radical.

M. Ikeda-Saito, D. Stuehr, Masao Ikeda-Saito, 1992, The Journal of biological chemistry.

Continuous nitric oxide synthesis by inducible nitric oxide synthase in normal human airway epithelium in vivo.

S. Erzurum, T. Rice, F. Thunnissen, 1995, Proceedings of the National Academy of Sciences of the United States of America.

Novel insights in mammalian catalase heme maturation: effect of NO and thioredoxin-1.

K. Gupta, Ritu Chakravarti, D. Stuehr, 2015, Free radical biology & medicine.

Inducible nitric oxide synthase: role of the N‐terminal β‐hairpin hook and pterin‐binding segment in dimerization and tetrahydrobiopterin interaction

J. Tainer, E. Getzoff, D. Wolan, 1999, The EMBO journal.

Regulation of the Monomer-Dimer Equilibrium in Inducible Nitric-oxide Synthase by Nitric Oxide*

D. Rousseau, K. Panda, D. Stuehr, 2006, Journal of Biological Chemistry.

Heme Distortion Modulated by Ligand-Protein Interactions in Inducible Nitric-oxide Synthase*

D. Rousseau, D. Stuehr, S. Yeh, 2004, Journal of Biological Chemistry.

Inactivation of soluble guanylyl cyclase in living cells proceeds without loss of haem and involves heterodimer dissociation as a common step

D. Stuehr, Yue Dai, 2021, British journal of pharmacology.

Superoxide generation mediated by 8-nitroguanosine, a highly redox-active nucleic acid derivative.

H. Maeda, T. Akaike, T. Akuta, 2003, Biochemical and biophysical research communications.

Generation of nitroxyl by heme protein-mediated peroxidation of hydroxylamine but not N-hydroxy-L-arginine.

G. C. Yeh, D. Wink, C. Switzer, 2008, Free radical biology & medicine.

Catalytic Reduction of a Tetrahydrobiopterin Radical within Nitric-oxide Synthase*

Zhi‐qiang Wang, R. Hille, D. Stuehr, 2008, Journal of Biological Chemistry.

Soluble guanylate cyclase as an alternative target for bronchodilator therapy in asthma

J. Stasch, S. Erzurum, S. Comhair, 2016, Proceedings of the National Academy of Sciences.

Bacterial Flavodoxins Support Nitric Oxide Production by Bacillus subtilis Nitric-oxide Synthase*♦

A. Munro, B. Crane, Zhi‐qiang Wang, 2007, Journal of Biological Chemistry.

A Pivotal Role for Tryptophan 447 in Enzymatic Coupling of Human Endothelial Nitric Oxide Synthase (eNOS)

S. Bhattacharya, M. Crabtree, K. Channon, 2013, The Journal of Biological Chemistry.

Dynamic regulation of NADPH oxidase 5 by intracellular heme levels and cellular chaperones

D. Stuehr, Elizabeth A. Sweeny, S. Schlanger, 2020, Redox biology.

Thioredoxin-1 Regulates Cellular Heme Insertion by Controlling S-Nitrosation of Glyceraldehyde-3-phosphate Dehydrogenase*

Ritu Chakravarti, D. Stuehr, 2012, The Journal of Biological Chemistry.

Comparative functioning of dihydro- and tetrahydropterins in supporting electron transfer, catalysis, and subunit dimerization in inducible nitric oxide synthase.

S. Erzurum, L. Huang, D. Stuehr, 1998, Biochemistry.

Analysis of substrate-induced electronic, catalytic, and structural changes in inducible NO synthase.

D. Stuehr, N. Sennequier, 1996, Biochemistry.

Intracellular Assembly of Inducible NO Synthase Is Limited by Nitric Oxide-mediated Changes in Heme Insertion and Availability

D. Stuehr, Q. A. Albakri, Qussay A. Albakri, 1996, The Journal of Biological Chemistry.

Macrophage nitric oxide synthase subunits. Purification, characterization, and role of prosthetic groups and substrate in regulating their association into a dimeric enzyme.

K. Baek, D. Stuehr, S. Lucas, 1993, The Journal of biological chemistry.

Tetrahydrobiopterin redox cycling in nitric oxide synthase: evidence supports a through‐heme electron delivery

M. Haque, D. Stuehr, M. Gangoda, 2016, The FEBS journal.

Mutational Analysis of the Tetrahydrobiopterin-binding Site in Inducible Nitric-oxide Synthase*

J. Tainer, E. Getzoff, D. Wolan, 1999, The Journal of Biological Chemistry.

Stopped-flow analysis of CO and NO binding to inducible nitric oxide synthase.

D. Stuehr, H. Abu-Soud, D. Ghosh, 1998, Biochemistry.

The Ferrous-dioxy Complex of Neuronal Nitric Oxide Synthase

F. Raushel, D. Stuehr, R. Gachhui, 1997, The Journal of Biological Chemistry.

Interactions between substrate analogues and heme ligands in nitric oxide synthase.

D. Rousseau, D. Stuehr, J. Wang, 1997, Biochemistry.

An inherent dysfunction in soluble guanylyl cyclase is present in the airway of severe asthmatics and is associated with aberrant redox enzyme expression and compromised NO-cGMP signaling

S. Erzurum, R. Panettieri, Arnab Ghosh, 2020, Redox biology.

Low levels of nitric oxide promotes heme maturation into several hemeproteins and is also therapeutic

S. Erzurum, H. Shimokawa, Arnab Ghosh, 2022, Redox biology.

Structure of a nitric oxide synthase heme protein from Bacillus subtilis.

B. Crane, A. Bilwes, D. Stuehr, 2002, Biochemistry.

Mammalian nitric oxide synthases.

O. Griffith, D. Stuehr, 1999, Advances in enzymology and related areas of molecular biology.

Tetrahydrobiopterin in nitric oxide synthase

D. Stuehr, J. Tejero, 2013, IUBMB life.

Charge-pairing interactions control the conformational setpoint and motions of the FMN domain in neuronal nitric oxide synthase.

M. Haque, D. Stuehr, M. Bayachou, 2013, The Biochemical journal.

How does a valine residue that modulates heme-NO binding kinetics in inducible NO synthase regulate enzyme catalysis?

Zhi‐qiang Wang, D. Stuehr, Chin-Chuan Wei, 2010, Journal of inorganic biochemistry.

Role of substrate functional groups in binding to nitric oxide synthase.

D. Rousseau, D. Stuehr, B. Fan, 2009, Biochemical and biophysical research communications.

Differences in a Conformational Equilibrium Distinguish Catalysis by the Endothelial and Neuronal Nitric-oxide Synthase Flavoproteins*

R. Hille, Robielyn P. Ilagan, D. Stuehr, 2008, Journal of Biological Chemistry.

Oxygenase domain of Drosophila melanogaster nitric oxide synthase: unique kinetic parameters enable a more efficient NO release.

T. Tully, A. Bhattacharjee, M. Regulski, 2007, Biochemistry.

Activation of Peroxynitrite by Inducible Nitric-oxide Synthase

T. Mattioli, D. Stuehr, A. Maréchal, 2007, Journal of Biological Chemistry.

Relationship between the structure of guanidines and N‐hydroxyguanidines, their binding to inducible nitric oxide synthase (iNOS) and their iNOS‐catalysed oxidation to NO

J. Boucher, D. Mansuy, D. Stuehr, 2005, The FEBS journal.

A Conserved Val to Ile Switch near the Heme Pocket of Animal and Bacterial Nitric-oxide Synthases Helps Determine Their Distinct Catalytic Profiles*

B. Crane, Manisha Sharma, Zhi‐qiang Wang, 2004, Journal of Biological Chemistry.

Distinct Influence of N-terminal Elements on Neuronal Nitric-oxide Synthase Structure and Catalysis*

K. Panda, D. Stuehr, K. Aulak, 2003, Journal of Biological Chemistry.

Chimeras of Nitric-oxide Synthase Types I and III Establish Fundamental Correlates between Heme Reduction, Heme-NO Complex Formation, and Catalytic Activity*

D. Stuehr, K. Aulak, S. Adak, 2001, The Journal of Biological Chemistry.

Molecular Basis for Hyperactivity in Tryptophan 409 Mutants of Neuronal NO Synthase*

D. Stuehr, S. Adak, Q. Wang, 2000, The Journal of Biological Chemistry.

Tryptophan 409 Controls the Activity of Neuronal Nitric-oxide Synthase by Regulating Nitric Oxide Feedback Inhibition*

Qian Wang, J. Tainer, E. Getzoff, 1999, The Journal of Biological Chemistry.

Electron transfer in the nitric-oxide synthases. Characterization of L-arginine analogs that block heme iron reduction.

D. Stuehr, P. Feldman, H. Abu-Soud, 1994, The Journal of biological chemistry.

Calmodulin controls neuronal nitric-oxide synthase by a dual mechanism. Activation of intra- and interdomain electron transfer.

D. Stuehr, H. Abu-Soud, L. L. Yoho, 1994, The Journal of biological chemistry.

Heme coordination of NO in NO synthase.

D. Rousseau, D. Stuehr, H. Abu-Soud, 1994, Proceedings of the National Academy of Sciences of the United States of America.

Substrate specificity of NO synthases: detailed comparison of L-arginine, homo-L-arginine, their N omega-hydroxy derivatives, and N omega-hydroxynor-L-arginine.

J. Boucher, D. Mansuy, M. Sari, 1998, Biochemistry.

Substrate Specificity of NO Synthases: Detailed Comparison of l-Arginine, Homo-l-arginine, Their Nω-Hydroxy Derivatives, and Nω-Hydroxynor-l-arginine†

J. Boucher, D. Mansuy, M. Sari, 1998 .

Characterization of Drosophila nitric oxide synthase: a biochemical study.

T. Tully, M. Regulski, Rupam Sahoo, 2003, Biochemical and biophysical research communications.

Thermodynamic characterization of five key kinetic parameters that define neuronal nitric oxide synthase catalysis

Zhi‐qiang Wang, M. Haque, D. Stuehr, 2013, The FEBS journal.

Soluble Guanylate Cyclase Agonists Induce Bronchodilation in Human Small Airways.

R. Panettieri, Arnab Ghosh, D. Stuehr, 2020, American journal of respiratory cell and molecular biology.

Mutation Nitric-oxide Synthase Stabilized by the Catalytic Intermediates of Inducible Enzymology :

D. Rousseau, T. Egawa, D. Stuehr, 2013 .

Catalytic Intermediates of Inducible Nitric-oxide Synthase Stabilized by the W188H Mutation*

D. Rousseau, T. Egawa, D. Stuehr, 2012, The Journal of Biological Chemistry.

Cotransplantation With Myeloid-Derived Suppressor Cells Protects Cell Transplants: A Crucial Role of Inducible Nitric Oxide Synthase

J. Fung, J. Qin, S. Qian, 2014, Transplantation.

Hsp90 chaperones hemoglobin maturation in erythroid and nonerythroid cells

Yukio Nakamura, Arnab Ghosh, D. Stuehr, 2018, Proceedings of the National Academy of Sciences.

Endothelial nitric oxide synthase oxygenase on lipid nanodiscs: A nano-assembly reflecting native-like function of eNOS.

M. Haque, D. Stuehr, Ghaith Altawallbeh, 2017, Biochemical and biophysical research communications.

Reactivity of the heme–dioxygen complex of the inducible nitric oxide synthase in the presence of alternative substrates

J. Boucher, D. Mansuy, D. Stuehr, 2006, The FEBS journal.

Formation and reactions of the heme-dioxygen intermediate in the first and second steps of nitric oxide synthesis as studied by stopped-flow spectroscopy under single-turnover conditions.

L. Huang, D. Stuehr, S. Boggs, 2000, Biochemistry.

Reconstitution of the second step in NO synthesis using the isolated oxygenase and reductase domains of macrophage NO synthase.

D. Stuehr, H. Abu-Soud, D. Ghosh, 1995, Biochemistry.

Heme coordination and structure of the catalytic site in nitric oxide synthase.

D. Rousseau, M. Ikeda-Saito, D. Stuehr, 1993, Journal of Biological Chemistry.

Picosecond photoreduction of inducible nitric oxide synthase by rhenium(I)-diimine wires.

H. Gray, A. Dunn, J. Winkler, 2005, Journal of the American Chemical Society.

NO synthase isozymes have distinct substrate binding sites.

D. Rousseau, D. Stuehr, J. Wang, 1997, Biochemistry.

Oxidations of N(omega)-hydroxyarginine analogues and various N-hydroxyguanidines by NO synthase II: key role of tetrahydrobiopterin in the reaction mechanism and substrate selectivity.

J. Boucher, D. Mansuy, D. Stuehr, 2001, Chemical research in toxicology.

A Conserved Tryptophan 457 Modulates the Kinetics and Extent of N-Hydroxy-l-Arginine Oxidation by Inducible Nitric-oxide Synthase*

Zhi‐qiang Wang, D. Stuehr, Chin-Chuan Wei, 2002, The Journal of Biological Chemistry.

Stopped-flow analysis of substrate binding to neuronal nitric oxide synthase.

D. Rousseau, D. Stuehr, H. Abu-Soud, 1999, Biochemistry.

Alterations of cellular bioenergetics in pulmonary artery endothelial cells

Raed A Dweik, Frank P DiFilippo, Thomas Koeck, 2007, Proceedings of the National Academy of Sciences.

Nitric oxide. A macrophage product responsible for cytostasis and respiratory inhibition in tumor target cells

C. Nathan, D. Stuehr, D J Stuehr, 1989, The Journal of experimental medicine.

Inhibition of Tumor Cell Ribonucleotide Reductase by Macrophage-derived Nitric Oxide By Nyoun

C. Nathan, N. Kwon, D. Stuehr, 2003 .

Tetrahydrobiopterin Radical Enzymology

B. Crane, D. Stuehr, Chin-Chuan Wei, 2003 .

A DNA microarray study of nitric oxide-induced genes in mouse hepatocytes: implications for hepatic heme oxygenase-1 expression in ischemia/reperfusion.

Ruben Zamora, Timothy R Billiar, Yoram Vodovotz, 2002, Nitric oxide : biology and chemistry.

Mammalian nitric oxide synthases.

D. Stuehr, 1999, Biochimica et biophysica acta.

Function of Mitochondrial Stat3 in Cellular Respiration

P. Fawcett, Xin-Yuan Fu, D. Baker, 2009, Science.

The surprising life of nitric oxide

O. Griffith, D. Stuehr, P. Feldman, 1993 .

The Reactions of Silver(I) With Tetraaza Macrocyclic Ligands

D. Stuehr, J. Knox, E. Blinn, 1989 .

Dynamic Regulation of the Inducible Nitric-oxide Synthase by NO

Zhi‐qiang Wang, D. Stuehr, J. Lambry, 2004, Journal of Biological Chemistry.

Structures of the N(omega)-hydroxy-L-arginine complex of inducible nitric oxide synthase oxygenase dimer with active and inactive pterins.

J. Tainer, E. Getzoff, B. Crane, 2000, Biochemistry.

Structure of nitric oxide synthase oxygenase dimer with pterin and substrate.

J. Tainer, E. Getzoff, B. Crane, 1998, Science.

Superoxide-promoted oxidation reactions of aniline and N-methylaniline in dimethyl sulfoxide

M. Marletta, D. Stuehr, 1985 .

Characterization of the 1st and 2nd EF-hands of NADPH oxidase 5 by fluorescence, isothermal titration calorimetry, and circular dichroism

Zhi‐qiang Wang, D. Stuehr, Chin-Chuan Wei, 2012, Chemistry Central Journal.

NADPH oxidase 5 by fluorescence, isothermal titration calorimetry, and circular dichroism

Zhi‐qiang Wang, D. Stuehr, Chin-Chuan Wei, 2012 .

Conformational States and Kinetics of the Calcium Binding Domain of NADPH Oxidase 5

D. Stuehr, Liu Qi Chen, Chin-Chuan Wei, 2010, The open biochemistry journal.

Inhibition of tumor cell ribonucleotide reductase by macrophage-derived nitric oxide

C. Nathan, N. Kwon, D. Stuehr, 1991, The Journal of experimental medicine.

Novel Mechanism of Activation of NADPH Oxidase 5

D. Fulton, M. Marrero, D. Stuehr, 2007, Journal of Biological Chemistry.

FT-Infrared spectroscopic studies of the iron ligand CO stretch mode of iNOS oxygenase domain: effect of arginine and tetrahydrobiopterin.

D. Stuehr, C. Jung, D. Ghosh, 2000, Biochemistry.

Antifungal Imidazoles Block Assembly of Inducible NO Synthase into an Active Dimer*

D. Wolan, D. Stuehr, N. Sennequier, 1999, The Journal of Biological Chemistry.

Nitric Oxide Generated by Corneas in Corneal Storage Media

J. Connor, J. Hollyfield, D. Stuehr, 2002, Cornea.

Anchored plasticity opens doors for selective inhibitor design in nitric oxide synthase

J. Tainer, E. Getzoff, R. Rosenfeld, 2008, Nature chemical biology.

Does endothelium-derived nitric oxide have a role in cytokine-induced hypotension?

C. Nathan, D. Stuehr, 1990, Journal of the National Cancer Institute.

Macrophage synthesis of nitrite, nitrate, and N-nitrosamines: precursors and role of the respiratory burst.

M. Marletta, D. Stuehr, R. Iyengar, 1987, Proceedings of the National Academy of Sciences of the United States of America.

Mammalian nitrate biosynthesis: mouse macrophages produce nitrite and nitrate in response to Escherichia coli lipopolysaccharide.

M. Marletta, D. Stuehr, 1985, Proceedings of the National Academy of Sciences of the United States of America.

4 – The Intracellular Reactions of Nitric Oxide in the Immune System and Its Enzymatic Synthesis

J. Lancaster, D. Stuehr, 1996 .

Purification and characterization of the cytokine-induced macrophage nitric oxide synthase: an FAD- and FMN-containing flavoprotein.

C. Nathan, N. Kwon, D. Stuehr, 1991, Proceedings of the National Academy of Sciences of the United States of America.

Mutants of Cytochrome P450 Reductase Lacking Either Gly-141 or Gly-143 Destabilize Its FMN Semiquinone*

L. Waskell, M. Haque, D. Stuehr, 2016, The Journal of Biological Chemistry.

Heme binding properties of glyceraldehyde-3-phosphate dehydrogenase.

J. Dawson, J. Brassard, Ritu Chakravarti, 2012, Biochemistry.

Synthesis and evaluation of new sulfur-containing L-arginine-derived inhibitors of nitric oxide synthase.

R. Atkinson, D. Stuehr, K. Ichimori, 1999, Journal of medicinal chemistry.

Reduced biopterin as a cofactor in the generation of nitrogen oxides by murine macrophages.

C. Nathan, N. Kwon, D. Stuehr, 1989, The Journal of biological chemistry.

Nitric oxide synthase enzymology in the 20 years after the Nobel Prize

M. Haque, D. Stuehr, Mohammad Mahfuzul Haque, 2018, British journal of pharmacology.

Occurrence, structure, and evolution of nitric oxide synthase–like proteins in the plant kingdom

G. Wong, M. Melkonian, D. Wendehenne, 2016, Science Signaling.

Metabolic activation of the antitumor drug 5-(Aziridin-1-yl)-2,4-dinitrobenzamide (CB1954) by NO synthases.

J. Boucher, D. Mansuy, D. Stuehr, 2008, Chemical research in toxicology.

Regulation of inducible nitric oxide synthase by self-generated NO.

D. Stuehr, K. Ichimori, H. Abu-Soud, 2001, Biochemistry.

Tetrahydrobiopterin-deficient nitric oxide synthase has a modified heme environment and forms a cytochrome P-420 analogue.

D. Rousseau, D. Stuehr, J. Wang, 1995, Biochemistry.

Engineering nitric oxide synthase chimeras to function as NO dioxygenases.

Manisha Sharma, Zhi‐qiang Wang, M. Haque, 2016, Journal of inorganic biochemistry.

Dissecting structural and electronic effects in inducible nitric oxide synthase.

S. Misra, M. Haque, D. Stuehr, 2015, The Biochemical journal.

Update on Mechanism and Catalytic Regulation in the NO Synthases*

Zhi‐qiang Wang, D. Stuehr, J. Santolini, 2004, Journal of Biological Chemistry.

A Conserved Aspartate (Asp-1393) Regulates NADPH Reduction of Neuronal Nitric-oxide Synthase

Manisha Sharma, K. Panda, D. Stuehr, 2004, Journal of Biological Chemistry.

Differences in Three Kinetic Parameters Underpin the Unique Catalytic Profiles of Nitric-oxide Synthases I, II, and III*

D. Stuehr, D J Stuehr, J. Santolini, 2001, The Journal of Biological Chemistry.

Indoleamine dioxygenase and tryptophan dioxygenase activities are regulated through control of cell heme allocation by nitric oxide

D. Stuehr, Pranjal Biswas, 2022, bioRxiv.

Indoleamine dioxygenase and tryptophan dioxygenase activities are regulated through GAPDH- and Hsp90-dependent control of their heme levels.

D. Stuehr, Yue Dai, Pranjal Biswas, 2022, Free radical biology & medicine.

Synergistic cooperation between T cell lymphokines for induction of the nitric oxide synthase gene in murine peritoneal macrophages.

C. Tannenbaum, D. Stuehr, T. Hamilton, 1993, Journal of immunology.

Nitric oxide synthases: properties and catalytic mechanism.

O. Griffith, D. Stuehr, Owen W. Griffith, 1995, Annual review of physiology.

Nitric oxide and nitric oxide‐generating compounds inhibit hepatocyte protein synthesis

T. Billiar, D. Stuehr, J. Stadler, 1991, FASEB journal : official publication of the Federation of American Societies for Experimental Biology.

Control of electron transfer in neuronal nitric oxide synthase by calmodulin, substrate, substrate analogs, and nitric oxide.

D. Rousseau, D. Stuehr, P. Feldman, 1995, Advances in pharmacology.

Protection of Extraribosomal RPL13a by GAPDH and Dysregulation by S-Nitrosylation.

S. Hazen, Jonathan D. Smith, D. Stuehr, 2023, Molecular cell.

Tyk2 Tyrosine Kinase Expression Is Required for the Maintenance of Mitochondrial Respiration in Primary Pro-B Lymphocytes

D. Baker, B. Hoit, S. Planchon, 2006, Molecular and Cellular Biology.

Dynamics of protein nitration in cells and mitochondria.

D. Stuehr, J. Crabb, T. Koeck, 2004, American journal of physiology. Heart and circulatory physiology.

The exchanged EF-hands in calmodulin and troponin C chimeras impair the Ca2+-induced hydrophobicity and alter the interaction with Orai1: a spectroscopic, thermodynamic and kinetic study

Zhi‐qiang Wang, D. Stuehr, Chin-Chuan Wei, 2015, BMC Biochemistry.

Abnormalities in nitric oxide and its derivatives in lung cancer.

R. Dweik, S. Erzurum, S. Comhair, 2005, American journal of respiratory and critical care medicine.

Recognition of alpha-amino acids bearing various C=NOH functions by nitric oxide synthase and arginase involves very different structural determinants.

D. Mansuy, M. Sari, D. Stuehr, 2000, Biochemistry.

Hsp90 and Its Role in Heme-Maturation of Client Proteins: Implications for Human Diseases

Arnab Ghosh, D. Stuehr, 2019, Heat Shock Proteins.

Substrate- and isoform-specific dioxygen complexes of nitric oxide synthase.

D. Rousseau, D. Stuehr, S. Yeh, 2007, Journal of the American Chemical Society.

Inhibition of macrophage and endothelial cell nitric oxide synthase by diphenyleneiodonium and its analogs 1

C. Nathan, N. Kwon, D. Stuehr, 1991, FASEB journal : official publication of the Federation of American Societies for Experimental Biology.

Evidence that L-arginine is the biosynthetic precursor of vascular and cardiac nitric oxide

O. Griffith, D. Stuehr, K. Aisaka, 1990 .

Structural Basis for Isozyme-specific Regulation of Electron Transfer in Nitric-oxide Synthase*[boxs]

J. Tainer, E. Getzoff, D. Hosfield, 2004, Journal of Biological Chemistry.

Oxygen Reduction by Nitric-oxide Synthases*

D. Stuehr, G. Rosen, S. Pou, 2001, The Journal of Biological Chemistry.

Glyceraldehyde-3-phosphate dehydrogenase is a chaperone that allocates labile heme in cells

Anuradha Singh, P. Dans, Osiris Martinez-Guzman, 2018, The Journal of Biological Chemistry.

Identification of arginine as a precursor of endothelium-derived relaxing factor.

C. Nathan, D. Stuehr, S. Gross, 1988, Proceedings of the National Academy of Sciences of the United States of America.

NO rapidly mobilizes cellular heme to trigger assembly of its own receptor

D. Stuehr, Arnab Ghosh, Yue Dai, 2022, Proceedings of the National Academy of Sciences.

GAPDH delivers heme to soluble guanylyl cyclase

Arnab Ghosh, D. Stuehr, Yue Dai, 2020, The Journal of Biological Chemistry.

N omega-hydroxy-L-arginine is an intermediate in the biosynthesis of nitric oxide from L-arginine.

C. Nathan, N. Kwon, O. Griffith, 1991, The Journal of biological chemistry.

First non-alpha-amino acid guanidines acting as efficient NO precursors upon oxidation by NO-synthase II or activated mouse macrophages.

J. Boucher, D. Mansuy, D. Stuehr, 2002, Biochemistry.

Role of Arginine Guanidinium Moiety in Nitric-oxide Synthase Mechanism of Oxygen Activation

J. Boucher, T. Mattioli, D. Stuehr, 2009, The Journal of Biological Chemistry.

Enzymes of the L-arginine to nitric oxide pathway.

D. Stuehr, 2004, The Journal of nutrition.

Mesohaem substitution reveals how haem electronic properties can influence the kinetic and catalytic parameters of neuronal NO synthase.

Zhi‐qiang Wang, R. Hille, D. Goodwin, 2011, The Biochemical journal.

Maturation, inactivation, and recovery mechanisms of soluble guanylyl cyclase

S. Misra, Arnab Ghosh, D. Stuehr, 2021, The Journal of biological chemistry.

N-nitrosamine formation by macrophages.

S. Tannenbaum, M. Marletta, D. Stuehr, 1987, IARC scientific publications.

Domain Swapping in Inducible Nitric-oxide Synthase

D. Wolan, D. Rousseau, D. Stuehr, 1998, The Journal of Biological Chemistry.

Direct Evidence for Nitric Oxide Production by a Nitric-oxide Synthase-like Protein from Bacillus subtilis *

D. Stuehr, K. Aulak, S. Adak, 2002, The Journal of Biological Chemistry.

Macrophage deactivating factor and transforming growth factors-beta 1 -beta 2 and -beta 3 inhibit induction of macrophage nitrogen oxide synthesis by IFN-gamma.

R. Derynck, J. Graycar, C. Nathan, 1990, Journal of immunology.

The structure of nitric oxide synthase oxygenase domain and inhibitor complexes.

J. Tainer, E. Getzoff, B. Crane, 1997, Science.

GAPDH is involved in the heme‐maturation of myoglobin and hemoglobin

D. Stuehr, Arnab Ghosh, Elizabeth A. Sweeny, 2021, FASEB journal : official publication of the Federation of American Societies for Experimental Biology.

Stabilization and Characterization of a Heme-Oxy Reaction Intermediate in Inducible Nitric-oxide Synthase*

J. Zweier, S. Misra, Zhi‐qiang Wang, 2008, Journal of Biological Chemistry.

Nitric oxide synthesis in the lung. Regulation by oxygen through a kinetic mechanism.

D. Laskowski, R. Dweik, S. Erzurum, 1998, The Journal of clinical investigation.

Subunit dissociation and unfolding of macrophage NO synthase: relationship between enzyme structure, prosthetic group binding, and catalytic function.

M. Loftus, D. Stuehr, H. Abu-Soud, 1995, Biochemistry.

A cross-domain charge interaction governs the activity of NO synthase

M. Haque, D. Stuehr, J. Tejero, 2018, The Journal of Biological Chemistry.

Glucose-modulated tyrosine nitration in beta cells: targets and consequences.

J. Corbett, D. Stuehr, J. Crabb, 2009, Archives of biochemistry and biophysics.

Proteomic method identifies proteins nitrated in vivo during inflammatory challenge

M. Miyagi, D. Stuehr, J. Crabb, 2001, Proceedings of the National Academy of Sciences of the United States of America.

Cloning, expression, and characterization of a nitric oxide synthase protein from Deinococcus radiodurans

J. Tainer, E. Getzoff, D. Hosfield, 2001, Proceedings of the National Academy of Sciences of the United States of America.

Nitric Oxide Binding to the Heme of Neuronal Nitric-oxide Synthase Links Its Activity to Changes in Oxygen Tension*

D. Rousseau, D. Stuehr, H. Abu-Soud, 1996, The Journal of Biological Chemistry.

Mechanism of Inducible Nitric-oxide Synthase Dimerization Inhibition by Novel Pyrimidine Imidazoles*

Arnab Ghosh, M. Haque, K. Panda, 2013, The Journal of Biological Chemistry.

Substrate binding and calmodulin binding to endothelial nitric oxide synthase coregulate its enzymatic activity.

W. Sessa, D. Stuehr, A. Presta, 1997, Nitric oxide : biology and chemistry.

Activated Murine Macrophages Secrete a Metabolite of Arginine with the Bioactivity of Endothelium-derived Relaxing Factor and the Chemical Reactivity of Nitric Oxide Materials and Methods

C. Nathan, D. Stuehr, S. Gross, 2022 .

Distinct Dimer Interaction and Regulation in Nitric-oxide Synthase Types I, II, and III*

E. Getzoff, R. Rosenfeld, K. Panda, 2002, The Journal of Biological Chemistry.

Isoform-specific effects of salts on nitric oxide synthase activity.

B. Mayer, D. Stuehr, A. Gorren, 1998, Biochimica et biophysica acta.

Phosphorylation inactivation of endothelial nitric oxide synthesis in pulmonary arterial hypertension.

S. Erzurum, S. Comhair, S. N. Naga Prasad, 2016, American journal of physiology. Lung cellular and molecular physiology.

Lys842 in Neuronal Nitric-oxide Synthase Enables the Autoinhibitory Insert to Antagonize Calmodulin Binding, Increase FMN Shielding, and Suppress Interflavin Electron Transfer*

E. Getzoff, M. Haque, D. Stuehr, 2009, The Journal of Biological Chemistry.

Neuronal Nitric-oxide Synthase Mutant (Ser-1412 → Asp) Demonstrates Surprising Connections between Heme Reduction, NO Complex Formation, and Catalysis*

Qian Wang, J. Johnson, D. Stuehr, 2001, The Journal of Biological Chemistry.

N‐terminal domain swapping and metal ion binding in nitric oxide synthase dimerization

J. Tainer, E. Getzoff, R. Rosenfeld, 1999, The EMBO journal.

Heat Shock Protein 90 Associates with the Per-Arnt-Sim Domain of Heme-free Soluble Guanylate Cyclase

S. Hazen, S. Misra, Arnab Ghosh, 2015, The Journal of Biological Chemistry.

Metal binding and conformational studies of the calcium binding domain of NADPH oxidase 5 reveal its similarity and difference to calmodulin

D. Stuehr, Chin-Chuan Wei, Nichole E. M. Kaufman, 2020, Journal of biomolecular structure & dynamics.

Single-molecule spectroscopy reveals how calmodulin activates NO synthase by controlling its conformational fluctuation dynamics

M. Haque, D. Stuehr, Yufan He, 2015, Proceedings of the National Academy of Sciences.

An ab initio study of an oxidative mechanism that forms nitric oxide from theN-hydroxyguanidinium ion

A. Sapse, D. Stuehr, D. Sapse, 1993 .

L-citrulline production from L-arginine by macrophage nitric oxide synthase. The ureido oxygen derives from dioxygen.

C. Nathan, N. Kwon, O. Griffith, 1990, The Journal of biological chemistry.

Mitochondria and regulated tyrosine nitration.

D. Stuehr, T. Koeck, K. Aulak, 2005, Biochemical Society transactions.

Abstracts from the 8th International Conference on cGMP Generators, Effectors and Therapeutic Implications

Jordi Villà-Freixa, Peter Sandner, Bernd J. Pichler, 2017, BMC Pharmacology and Toxicology.

Function of Mitochondrial Stat 3 in Cellular Respiration

P. Fawcett, Xin-Yuan Fu, D. Baker, 2022 .

Functional interactions between NADPH oxidase 5 and actin

D. Stuehr, Elizabeth A. Sweeny, S. Richter, 2023, Frontiers in Cell and Developmental Biology.

Mechanism and regulation of ferrous heme-nitric oxide (NO) oxidation in NO synthases

N. Lehnert, D. Stuehr, J. Santolini, 2019, The Journal of Biological Chemistry.

FAD and GSH participate in macrophage synthesis of nitric oxide.

C. Nathan, N. Kwon, D. Stuehr, 1990, Biochemical and biophysical research communications.

Purification and properties of nitric oxide synthases.

D. Stuehr, 1996, Methods in enzymology.

Reductase domain of Drosophila melanogaster nitric-oxide synthase: redox transformations, regulation, and similarity to mammalian homologues.

T. Tully, M. Regulski, Rupam Sahoo, 2007, Biochemistry.

Characterization of the Reductase Domain of Rat Neuronal Nitric Oxide Synthase Generated in the Methylotrophic Yeast Pichia pastoris

G. Brudvig, D. Stuehr, R. Gachhui, 1996, The Journal of Biological Chemistry.

Resonance Raman study of Bacillus subtilis NO synthase-like protein: similarities and differences with mammalian NO synthases.

T. Mattioli, D. Stuehr, J. Santolini, 2006, Biochemistry.

Immunohistochemical Localization of eNOS, iNOS, bNOS, and Peroxynitrite in Stored Human Corneas

J. Hollyfield, D. Stuehr, D. Meisler, 2002 .

Influence of Heme-Thiolate in Shaping the Catalytic Properties of a Bacterial Nitric-oxide Synthase*

D. Stuehr, J. Tejero, L. Hannibal, 2011, The Journal of Biological Chemistry.

Arginine Conversion to Nitroxide by Tetrahydrobiopterin-free Neuronal Nitric-oxide Synthase

Qian Wang, D. Stuehr, Dennis J. Stuehr, 2000, The Journal of Biological Chemistry.

Characterization of the inducible nitric oxide synthase oxygenase domain identifies a 49 amino acid segment required for subunit dimerization and tetrahydrobiopterin interaction.

E. Werner, B. Mayer, D. Stuehr, 1997, Biochemistry.

Protein Tyrosine Nitration in the Mitochondria from Diabetic Mouse Heart

F. Murad, D. Stuehr, I. Turko, 2003, Journal of Biological Chemistry.

Hydrogen sulfide and nitric oxide metabolites in the blood of free-ranging brown bears and their potential roles in hibernation.

F. Jensen, A. Evans, J. Kindberg, 2014, Free radical biology & medicine.

Reduction of nilutamide by NO synthases: implications for the adverse effects of this nitroaromatic antiandrogen drug.

J. Boucher, D. Mansuy, M. Sari, 2003, Chemical research in toxicology.

Nitric oxidesynthases reveal aroleforcalmodulin incontrolling electron transfer (flavoprotein/cytochrome P-450/calcium-bindIng protein/arginine)

D. Stuehr, H. Abu-Soud, 1993 .

Calmodulin Activates Intersubunit Electron Transfer in the Neuronal Nitric-oxide Synthase Dimer*

K. Panda, D. Stuehr, Sanjay Ghosh, 2001, The Journal of Biological Chemistry.

Neuronal Nitric Oxide Synthase Self-inactivates by Forming a Ferrous-Nitrosyl Complex during Aerobic Catalysis (*)

L. Ignarro, D. Rousseau, D. Stuehr, 1995, The Journal of Biological Chemistry.

A Kinetic Simulation Model That Describes Catalysis and Regulation in Nitric-oxide Synthase*

D. Stuehr, J. Santolini, S. Adak, 2001, The Journal of Biological Chemistry.

Heat shock protein 90 regulates soluble guanylyl cyclase maturation by a dual mechanism

S. Misra, M. Haque, D. Stuehr, 2019, The Journal of Biological Chemistry.

Mechanistic Studies with Potent and Selective Inducible Nitric-oxide Synthase Dimerization Inhibitors*

Sanjay Ghosh, Douglas S. Auld, Wei Xia, 2002, The Journal of Biological Chemistry.

Distal Val346Ile mutation in inducible NO synthase promotes substrate-dependent NO confinement.

Zhi‐qiang Wang, D. Stuehr, J. Lambry, 2007, Biochemistry.

A tryptophan that modulates tetrahydrobiopterin-dependent electron transfer in nitric oxide synthase regulates enzyme catalysis by additional mechanisms.

Zhi‐qiang Wang, K. Panda, D. Stuehr, 2005, Biochemistry.

A conserved tryptophan in nitric oxide synthase regulates heme-dioxy reduction by tetrahydrobiopterin.

S. Ghosh, R. Hille, D. Stuehr, 2001, Biochemistry.

Nitric oxide synthases-from genes to function.

D. Stuehr, J. Vasquez-Vivar, 2017, Nitric oxide : biology and chemistry.

Efficient formation of nitric oxide from selective oxidation of N-aryl N'-hydroxyguanidines by inducible nitric oxide synthase.

J. Boucher, D. Mansuy, D. Stuehr, 1999, Biochemistry.

Reactivity of the flavin semiquinone of nitric oxide synthase in the oxygenation of arginine to NG-hydroxyarginine, the first step of nitric oxide synthesis.

S. Kaufman, M. B. Yim, D. Stuehr, 1998, Biochemical and biophysical research communications.

Analysis of neuronal NO synthase under single-turnover conditions: conversion of Nomega-hydroxyarginine to nitric oxide and citrulline.

B. Mayer, D. Stuehr, A. Presta, 1997, Biochemistry.

Identification of Nitric Oxide Synthase as a Thiolate-ligated Heme Protein Using Magnetic Circular Dichroism Spectroscopy

M. Ikeda-Saito, J. Dawson, D. Stuehr, 1995, The Journal of Biological Chemistry.

Synthesis of nitrogen oxides from L-arginine by macrophage cytosol: requirement for inducible and constitutive components.

C. Nathan, N. Kwon, D. Stuehr, 1989, Biochemical and biophysical research communications.

Luminescent ruthenium(II)- and rhenium(I)-diimine wires bind nitric oxide synthase.

E. Getzoff, H. Gray, A. Dunn, 2005, Journal of the American Chemical Society.

Heme Iron Reduction and Catalysis by a Nitric Oxide Synthase Heterodimer Containing One Reductase and Two Oxygenase Domains (*)

D. Stuehr, H. Abu-Soud, D. Ghosh, 1996, The Journal of Biological Chemistry.

Nitric oxide-generated P420 nitric oxide synthase: characterization and roles for tetrahydrobiopterin and substrate in protecting against or reversing the P420 conversion.

R. Hille, D. Stuehr, H. Abu-Soud, 1999, Biochemistry.

Exploring the redox reactions between heme and tetrahydrobiopterin in the nitric oxide synthases.

Zhi‐qiang Wang, R. Hille, D. Stuehr, 2005, Dalton transactions.

Why do nitric oxide synthases use tetrahydrobiopterin?

Zhi‐qiang Wang, D. Stuehr, Chin-Chuan Wei, 2002, Journal of inorganic biochemistry.

Fast ferrous heme–NO oxidation in nitric oxide synthases

Jérôme Santolini, D. Stuehr, J. Santolini, 2009, The FEBS journal.

Neutralizing a Surface Charge on the FMN Subdomain Increases the Activity of Neuronal Nitric-oxide Synthase by Enhancing the Oxygen Reactivity of the Enzyme Heme-Nitric Oxide Complex*

Zhi‐qiang Wang, M. Haque, K. Panda, 2009, The Journal of Biological Chemistry.

A proximal tryptophan in NO synthase controls activity by a novel mechanism.

D. Stuehr, S. Adak, 2001, Journal of inorganic biochemistry.

Neuronal Nitric-oxide Synthase Interaction with Calmodulin-Troponin C Chimeras

B. Mayer, S. George, D. Stuehr, 1998, The Journal of Biological Chemistry.

Arg375 tunes tetrahydrobiopterin functions and modulates catalysis by inducible nitric oxide synthase.

Zhi‐qiang Wang, M. Haque, D. Stuehr, 2012, Journal of inorganic biochemistry.

Control of Electron Transfer and Catalysis in Neuronal Nitric-oxide Synthase (nNOS) by a Hinge Connecting Its FMN and FAD-NADPH Domains*

Arnab Ghosh, M. Haque, D. Stuehr, 2012, The Journal of Biological Chemistry.

A Bridging Interaction Allows Calmodulin to Activate NO Synthase through a Bi-modal Mechanism*

M. Haque, D. Stuehr, J. Tejero, 2010, The Journal of Biological Chemistry.

Versatile regulation of neuronal nitric oxide synthase by specific regions of its C-terminal tail.

K. Panda, D. Stuehr, K. Aulak, 2007, Biochemistry.

A connecting hinge represses the activity of endothelial nitric oxide synthase

M. Haque, K. Panda, D. Stuehr, 2007, Proceedings of the National Academy of Sciences.

Role of Asp1393 in catalysis, flavin reduction, NADP(H) binding, FAD thermodynamics, and regulation of the nNOS flavoprotein.

Manisha Sharma, D. Stuehr, N. Takaya, 2006, Biochemistry.

Tetrahydrobiopterin radical enzymology.

B. Crane, D. Stuehr, Chin-Chuan Wei, 2003, Chemical reviews.

Regulation of the properties of the heme-NO complexes in nitric-oxide synthase by hydrogen bonding to the proximal cysteine.

D. Rousseau, D. Stuehr, M. Couture, 2001, The Journal of biological chemistry.

Rapid Kinetic Studies Link Tetrahydrobiopterin Radical Formation to Heme-dioxy Reduction and Arginine Hydroxylation in Inducible Nitric-oxide Synthase*

Qianqian Wang, Zhi‐qiang Wang, R. Hille, 2001, The Journal of Biological Chemistry.

Nitric oxide synthase: use of stopped-flow spectroscopy and rapid-quench methods in single-turnover conditions to examine formation and reactions of heme-O2 intermediate in early catalysis.

Zhi‐qiang Wang, D. Stuehr, Chin-Chuan Wei, 2002, Methods in enzymology.

Domains of macrophage N(O) synthase have divergent roles in forming and stabilizing the active dimeric enzyme.

D. Stuehr, H. Abu-Soud, D. Ghosh, 1996, Biochemistry.

A conserved flavin-shielding residue regulates NO synthase electron transfer and nicotinamide coenzyme specificity

Manisha Sharma, D. Stuehr, S. Adak, 2002, Proceedings of the National Academy of Sciences of the United States of America.

Macrophage NO synthase: characterization of isolated oxygenase and reductase domains reveals a head-to-head subunit interaction.

D. Stuehr, D. Ghosh, Dipak K. Ghosh, 1995, Biochemistry.

Mechanisms of Mammalian Nitric Oxide Biosynthesis

O. Griffith, D. Stuehr, J. Fukuto, 1995 .

Hemoglobin resident in the lung epithelium is protective for smooth muscle soluble guanylate cyclase function

S. Erzurum, S. Comhair, D. Stuehr, 2023, Redox biology.

Peracid oxidation of an N-hydroxyguanidine compound: a chemical model for the oxidation of N omega-hydroxyl-L-arginine by nitric oxide synthase.

M. Bova, D. Stuehr, J. Fukuto, 1993, Journal of medicinal chemistry.

A Tetrahydrobiopterin Radical Forms and then Becomes Reduced during Nω-Hydroxyarginine Oxidation by Nitric-oxide Synthase*

Zhi‐qiang Wang, R. Hille, D. Stuehr, 2003, Journal of Biological Chemistry.

Spectroscopic characterization of five- and six-coordinate ferrous-NO heme complexes. Evidence for heme Fe-proximal cysteinate bond cleavage in the ferrous-NO adducts of the Trp-409Tyr/Phe proximal environment mutants of neuronal nitric oxide synthase.

D. Goodin, M. Ikeda-Saito, J. Dawson, 2003, Biochemistry.

Formation of nitric oxide synthase-iron(II) nitrosoalkane complexes: severe restriction of access to the iron(II) site in the presence of tetrahydrobiopterin.

J. Boucher, D. Mansuy, M. Sari, 1998, Biochemistry.

Further studies on murine macrophage synthesis of nitrite and nitrate.

M. Marletta, D. Stuehr, 1987, IARC scientific publications.

Nitric Oxide and heme-NO stimulate superoxide production by NADPH Oxidase 5.

N. Lehnert, D. Stuehr, Elizabeth A. Sweeny, 2021, Free radical biology & medicine.

A natural heme deficiency exists in biology that allows nitric oxide to control heme protein functions by regulating cellular heme distribution

D. Stuehr, Dhanya T. Jayaram, Pranjal Biswas, 2023, BioEssays : news and reviews in molecular, cellular and developmental biology.

New roles for GAPDH, Hsp90, and NO in regulating heme allocation and hemeprotein function in mammals

D. Stuehr, Arnab Ghosh, Elizabeth A. Sweeny, 2022, Biological chemistry.

Unbiased proteomics identifies plasminogen activator inhibitor-1 as a negative regulator of endothelial nitric oxide synthase

W. Sessa, D. Stuehr, B. Isakson, 2020, Proceedings of the National Academy of Sciences.

Radical reactions of nitric oxide synthases.

E. Getzoff, D. Stuehr, J. Santolini, 2004, Biochemical Society symposium.

Specific O-GlcNAc modification at Ser-615 modulates eNOS function

R. Dweik, Liping Tian, M. Haque, 2020, Redox biology.

Multiple cytokines are required to induce hepatocyte nitric oxide production and inhibit total protein synthesis.

T. Billiar, B. Harbrecht, R. Simmons, 1990, Annals of surgery.

Inducible cytosolic enzyme activity for the production of nitrogen oxides from L-arginine in hepatocytes.

T. Billiar, R. Simmons, D. Stuehr, 1990, Biochemical and biophysical research communications.

Expression of human inducible nitric oxide synthase in a tetrahydrobiopterin (H4B)-deficient cell line: H4B promotes assembly of enzyme subunits into an active dimer.

P. Robbins, T. Billiar, M. Loftus, 1995, Proceedings of the National Academy of Sciences of the United States of America.

Abstracts from the 8th International Conference on cGMP Generators, Effectors and Therapeutic Implications

James C. Campbell, Dong I. Lee, M. Zaccolo, 2017, BMC Pharmacology and Toxicology.

Stopped-flow analysis of no binding to inducible nitric oxide synthase

D. Stuehr, H. Abu-Soud, D. Ghosh, 1998 .

Expression of human inducible nitric oxide synthase in a tetrahydrobiopterin (H4B)-deficient cell line: H4B promotes assembly of enzyme subunits into an active dimer.

T. Billiar, D. Stuehr, E. Tzeng, 1995, Proceedings of the National Academy of Sciences of the United States of America.

Neutralizing a Surface Charge on the FMN Subdomain Increases the Activity of Neuronal Nitric-oxide Synthase by Enhancing the Oxygen Reactivity of the Enzyme Heme-Nitric Oxide Complex*

Zhi‐qiang Wang, M. Haque, K. Panda, 2009, The Journal of Biological Chemistry.

Calcium Signaling: NO Synthase

D. Stuehr, Zhi Qiang Wang, 2013 .

Cytostasis from nitrite a product of activated macrophages

C. Nathan, D. Stuehr, C. Morris, 1988 .

Enzymes of the L-arginine to nitric oxide pathway.

D. Stuehr, 2004, The Journal of nutrition.

Activated murine macrophages secrete a metabolite of arginine with the bioactivity of endothelium-derived relaxing factor and the chemical reactivity of nitric oxide

D. Stuehr, I. Sakuma, Steven S. Gross, 1989, The Journal of experimental medicine.

Synthesis of the L-arginine congener L-indospicine and evaluation of its interaction with nitric oxide synthase

D. Stuehr, P. Feldman, S. Chi, 1996 .

Erratum: EPR spectroscopic characterization of neuronal NO synthase (Biochemistry (February 27, 1996) 35:8 (2804-2810))

D. Stuehr, R. Macarthur, H. Abu-Soud, 1996 .

Heme binding properties of glyceraldehyde-3-phosphate dehydrogenase.

J. Dawson, J. Brassard, Ritu Chakravarti, 2012, Biochemistry.

Oxygen Reduction by Nitric-oxide Synthases*

D. Stuehr, G. Rosen, S. Pou, 2001, The Journal of Biological Chemistry.

Hydrogen sulfide and nitric oxide metabolites in the blood of free-ranging brown bears and their potential roles in hibernation.

F. Jensen, J. Kindberg, A. Fago, 2014, Free radical biology & medicine.

Heme delivery to heme oxygenase-2 involves glyceraldehyde-3-phosphate dehydrogenase

Liu Liu, A. Fleischhacker, S. Ragsdale, 2022, Biological chemistry.

Protection of extraribosomal RPL13a by GAPDH and dysregulation by S-nitrosylation.

S. Hazen, Jonathan D. Smith, D. Stuehr, 2012, Molecular cell.

Engineering nitric oxide synthase chimeras to function as NO dioxygenases.

Manisha Sharma, Zhi‐qiang Wang, M. Haque, 2016, Journal of inorganic biochemistry.

Structure of tetrahydrobiopterin tunes its electron transfer to the heme-dioxy intermediate in nitric oxide synthase.

E. Getzoff, Zhi‐qiang Wang, R. Hille, 2003, Biochemistry.

Nitric Oxide and Heat Shock Protein 90 Activate Soluble Guanylate Cyclase by Driving Rapid Change in Its Subunit Interactions and Heme Content*

J. Stasch, A. Papapetropoulos, Arnab Ghosh, 2014, Journal of Biological Chemistry.

P174 - Probing the mechanism of tetrahydrobiopterin radical reduction within NO synthases

M. Haque, D. Stuehr, J. Tejero, 2014 .

Human Endothelial Nitric Oxide Synthase with 7-Nitroindazole Bound

J. Tainer, E. Getzoff, R. Rosenfeld, 2002 .

inducible nitric oxide synthase with 5-nitroindazole bound

J. Tainer, E. Getzoff, R. Rosenfeld, 2002 .

human endothelial nitric oxide synthase with 6-nitroindazole bound

J. Tainer, E. Getzoff, R. Rosenfeld, 2002 .

human endothelial nitric oxide synthase with 5-nitroindazole bound

J. Tainer, E. Getzoff, R. Rosenfeld, 2002 .

NO synthase isoforms specifically modify peroxynitrite reactivity

T. Mattioli, D. Stuehr, A. Maréchal, 2010, The FEBS journal.

Mesohaem substitution reveals how haem electronic properties can influence the kinetic and catalytic parameters of neuronal NO synthase.

Zhi‐qiang Wang, R. Hille, D. Goodwin, 2011, The Biochemical journal.

BAY58-2667 Activates Different Soluble Guanylyl Cyclase Species by Distinct Mechanisms that Indicate Its Principal Target in Cells is the Heme-Free Soluble Guanylyl Cyclase-Heat Shock Protein 90 Complex

D. Stuehr, Yue Dai, 2023, Molecular Pharmacology.