M. Hack

发表

Discovery of the first known small-molecule inhibitors of heme-regulated eukaryotic initiation factor 2alpha (HRI) kinase.

M. Rosen, C. Woods, S. Goldberg, 2009, Bioorganic & medicinal chemistry letters.

Structural Basis of Small-Molecule Aggregate Induced Inhibition of a Protein-Protein Interaction.

Taraneh Mirzadegan, Michael D Hack, Alec D Lebsack, 2017, Journal of medicinal chemistry.

A Single Amino Acid Difference between Mouse and Human 5-Lipoxygenase Activating Protein (FLAP) Explains the Speciation and Differential Pharmacology of Novel FLAP Inhibitors*

M. Milla, T. Mirzadegan, M. Hack, 2016, The Journal of Biological Chemistry.

Chimeric, mutant orexin receptors show key interactions between orexin receptors, peptides and antagonists.

P. Bonaventure, C. Dvorak, T. Lovenberg, 2011, European journal of pharmacology.

Discovery of potent cholecystokinin-2 receptor antagonists: elucidation of key pharmacophore elements by X-ray crystallographic and NMR conformational analysis.

Jiejun Wu, C. Schubert, M. Rosen, 2008, Bioorganic & medicinal chemistry.

Tetrahydroindazole inhibitors of bacterial type II topoisomerases. Part 2: SAR development and potency against multidrug-resistant strains.

John J. M. Wiener, Cheryl A. Grice, M. Hack, 2007, Bioorganic & medicinal chemistry letters.

Novel pyrazole derivatives as potent inhibitors of type II topoisomerases. Part 1: synthesis and preliminary SAR analysis.

John J. M. Wiener, Cheryl A. Grice, M. Hack, 2007, Bioorganic & medicinal chemistry letters.

SAR studies of 1,5-diarylpyrazole-based CCK1 receptor antagonists.

M. Hack, T. Barrett, N. Shankley, 2007, Bioorganic & medicinal chemistry letters.

2-Aryl benzimidazoles featuring alkyl-linked pendant alcohols and amines as inhibitors of checkpoint kinase Chk2.

L. Karlsson, M. Hack, A. Brunmark, 2007, Bioorganic & medicinal chemistry letters.

Discovery and synthesis of 6,7,8,9-tetrahydro-5H-pyrimido-[4,5-d]azepines as novel TRPV1 antagonists.

Hong Ao, A. Bhattacharya, M. Hack, 2010, Bioorganic & medicinal chemistry letters.

Discovery and SAR of 6-alkyl-2,4-diaminopyrimidines as histamine H₄ receptor antagonists.

R. Thurmond, J. Edwards, M. Hack, 2014, Journal of medicinal chemistry.

Pyrazole CCK(1) receptor antagonists. Part 1: Solution-phase library synthesis and determination of Free-Wilson additivity.

M. Hack, T. Barrett, N. Shankley, 2006, Bioorganic & medicinal chemistry letters.

Identification and optimization of anthranilic sulfonamides as novel, selective cholecystokinin-2 receptor antagonists.

M. Rosen, C. Woods, M. Hack, 2006, Journal of medicinal chemistry.

Identification and synthesis of 2,7-diamino-thiazolo[5,4-d]pyrimidine derivatives as TRPV1 antagonists.

M. Peterson, Hong Ao, A. Bhattacharya, 2009, Bioorganic & medicinal chemistry letters.

R3(BΔ23–27)R/I5 Chimeric Peptide, a Selective Antagonist for GPCR135 and GPCR142 over Relaxin Receptor LGR7

P. Bonaventure, F. Kamme, T. Lovenberg, 2007, Journal of Biological Chemistry.

Impact of Protein Preparation on Resulting Accuracy of FEP Calculations

Taraneh Mirzadegan, Amy Y Shih, Michael Hack, 2020, J. Chem. Inf. Model..

R3(BDelta23 27)R/I5 chimeric peptide, a selective antagonist for GPCR135 and GPCR142 over relaxin receptor LGR7: in vitro and in vivo characterization.

P. Bonaventure, F. Kamme, T. Lovenberg, 2007, The Journal of biological chemistry.

1 R 3 ( B ∆ 23-27 ) R / I 5 CHIMERIC PEPTIDE , A SELECTIVE ANTAGONIST FOR GPCR 135 AND GPCR 142 OVER RELAXIN RECEPTOR LGR 7 : IN VITRO AND IN VIVO CHARACTERIZATION

P. Bonaventure, F. Kamme, Jiejun Wu, 2007 .

Library Enhancement through the Wisdom of Crowds

Dimitris K. Agrafiotis, Dmitrii N. Rassokhin, Andrew Skalkin, 2011, J. Chem. Inf. Model..

An Analysis of Different Components of a High-Throughput Screening Library

Taraneh Mirzadegan, Arjun Saha, Teena Varghese, 2018, J. Chem. Inf. Model..

Identification of 2-arylbenzimidazoles as potent human histamine H4 receptor ligands.

James P Edwards, Lars Karlsson, J Guy Breitenbucher, 2006, Bioorganic & medicinal chemistry letters.

Pyrazole CCK(1) receptor antagonists. Part 2: SAR studies by solid-phase library synthesis and determination of Free-Wilson additivity.

M. Hack, T. Barrett, N. Shankley, 2006, Bioorganic & medicinal chemistry letters.