J. Manson

发表

α‐Hemoglobin stabilizing protein is not a suitable marker for a screening test for variant Creutzfeldt‐Jakob disease

C. Prowse, N. E. Appleford, K. Wilson, 2008, Transfusion.

Analysis of gene expression in the nervous system identifies key genes and novel candidates for health and disease

Sarah M. Carpanini, T. Gillingwater, K. Summers, 2017, neurogenetics.

Explorer Analysis of gene expression in the nervous system identifies key genes and novel candidates for health and disease

Sarah M. Carpanini, T. Gillingwater, K. Summers, 2017 .

High Titers of Transmissible Spongiform Encephalopathy Infectivity Associated with Extremely Low Levels of PrPSc in Vivo*

Declan King, R. Williamson, J. Manson, 2007, Journal of Biological Chemistry.

The transmissible spongiform encephalopathies: emerging and declining epidemics.

M. Bishop, J. Manson, E. Cancellotti, 2006, Biochemical Society transactions.

Polymorphisms at codons 108 and 189 in murine PrP play distinct roles in the control of scrapie incubation time.

Richard C. Moore, D. Melton, Declan King, 2005, The Journal of general virology.

Transmission of murine scrapie to P101L transgenic mice.

D. Melton, Declan King, J. Manson, 2003, The Journal of general virology.

Dissociation of Prion Protein Amyloid Seeding from Transmission of a Spongiform Encephalopathy

G. Telling, Declan King, J. Manson, 2013, Journal of Virology.

The role of the misfolded prion protein in neurodegeneration

J. Manson, V. Perry, James D. Alibhai, 2015 .

The role of the immune system in prion infection.

N. Mabbott, J. Manson, James D. Alibhai, 2018, Handbook of clinical neurology.

Variant CJD

J. Ironside, J. Manson, R. Will, 2014, Prion.

Short Communication Chronic wasting disease and atypical forms of bovine spongiform encephalopathy and scrapie are not transmissible to mice expressing wild-type levels of human prion protein

N. Hunter, F. Tagliavini, M. Simmons, 2012 .

Expression of doppel in the CNS of mice does not modulate transmissible spongiform encephalopathy disease.

D. Melton, J. Manson, N. Tuzi, 2002, The Journal of general virology.

Soluble mediators of immunity: interleukins

J. Symons, G. Duff, J. Manson, 1988 .

Cellular prion protein regulates β-secretase cleavage of the Alzheimer's amyloid precursor protein

N. Hooper, C. Eckman, J. Manson, 2007, Proceedings of the National Academy of Sciences.

Subclinical infection occurs frequently following low dose exposure to prions by blood transfusion

J. Manson, H. Brown, M. Salamat, 2022, Scientific Reports.

The Glycosylation Status of PrPC Is a Key Factor in Determining Transmissible Spongiform Encephalopathy Transmission between Species

J. Ironside, J. Manson, E. Cancellotti, 2015, Journal of Virology.

Human embryonic stem cells rapidly take up and then clear exogenous human and animal prions in vitro

K. Samuel, M. Turner, J. Ironside, 2011, The Journal of pathology.

Effects of human PrPSc type and PRNP genotype in an in-vitro conversion assay

C. Prowse, M. Turner, J. Ironside, 2008, Neuroreport.

Host PrP Glycosylation: A Major Factor Determining the Outcome of Prion Infection

J. Manson, E. Cancellotti, R. Barron, 2008, PLoS biology.

The role of host PrP in control of incubation time

M. Bishop, J. Manson, R. Barron, 2005 .

129/Ola mice carrying a null mutation in PrP that abolishes mRNA production are developmentally normal

I. Mcconnell, A. Clarke, J. Manson, 1994, Molecular Neurobiology.

A novel, resistance-linked ovine PrP variant and its equivalent mouse variant modulate the in vitro cell-free conversion of rPrP to PrP(res).

W. Goldmann, F. Houston, J. Manson, 2006, The Journal of general virology.

Embryonic activation and developmental expression of the murine prion protein gene.

S. Horvat, G. Miele, J. Manson, 2003, Gene expression.

T‐lymphocyte activation and the cellular form of the prion protein

N. Mabbott, J. Manson, M. Bruce, 1997, Immunology.

Characterisation of two promoters for prion protein (PrP) gene expression in neuronal cells.

J. Manson, H. Baybutt, 1997, Gene.

PrP-Deficient Mice in the Study of Transmissible Spongiform Encephalopathies

J. Manson, 1996 .

Transgenic Mice Modelling

M. Bishop, J. Manson, E. Cancellotti, 2013 .

A single amino acid alteration in murine PrP dramatically alters TSE incubation time.

I. Mcconnell, D. Melton, J. Manson, 2000, Archives of virology. Supplementum.

Double Replacement Gene Targeting for the Production of a Series of Mouse Strains with Different Prion Protein Gene Alterations

Richard C. Moore, J. Selfridge, D. Melton, 1995, Bio/Technology.

The prion protein gene

M. Kaufman, J. Manson, Thomson, 1992 .

The Use of Transgenic and Knockout Mice in Prion Research

J. Manson, A. Diack, Abigail B. Diack, 2017 .

Gene Targeted Transgenic Mouse Models in Prion Research.

J. Manson, James D. Alibhai, A. Diack, 2017, Progress in molecular biology and translational science.

Evaluating the Species Barrier.

J. Manson, A. Diack, Abigail B. Diack, 2016, Food safety.

Molecular Barriers to Zoonotic Transmission of Prions

J. Ironside, J. Manson, M. Head, 2014, Emerging infectious diseases.

No Major Change in vCJD Agent Strain after Secondary Transmission via Blood Transfusion

J. Ironside, M. Bishop, J. Manson, 2008, PloS one.

Edinburgh Unravelling the glial response in the pathogenesis of Alzheimer's Disease

J. Manson, James D. Alibhai, A. Diack, 2018 .

Defining sporadic Creutzfeldt-Jakob disease strains and their transmission properties

M. Bishop, J. Manson, R. Will, 2010, Proceedings of the National Academy of Sciences.

Follicular Dendritic Cell-Specific Prion Protein (PrPc) Expression Alone Is Sufficient to Sustain Prion Infection in the Spleen

K. Rajewsky, K. Brown, N. Mabbott, 2011, PLoS pathogens.

A polymorphism in the regulatory region of PRNP is associated with increased risk of sporadic Creutzfeldt-Jakob disease

C. V. van Duijn, P. Sánchez-Juan, M. Bishop, 2011, BMC Medical Genetics.

Significant differences in incubation times in sheep infected with bovine spongiform encephalopathy result from variation at codon 141 in the PRNP gene.

C. de Wolf, W. Goldmann, J. Manson, 2012, The Journal of general virology.

Explorer Molecular barriers to zoonotic transmission of prions

J. Ironside, A. Barria, J. Manson, 2022 .

Preclinical transmission of prions by blood transfusion is influenced by donor genotype and route of infection

C. de Wolf, M. Turner, O. Andréoletti, 2021, PLoS pathogens.

Variant Creutzfeldt-Jakob disease strain is identical in individuals of two PRNP codon 129 genotypes

M. Bishop, J. Manson, R. Will, 2019, Brain : a journal of neurology.

Variant Creutzfeldt-Jakob disease strain is identical in individuals of two PRNP codon 129 genotypes

M. Bishop, J. Manson, R. Will, 2019, Brain : a journal of neurology.

Public health risks from subclinical variant CJD

J. Manson, R. Will, A. Diack, 2017, PLoS pathogens.

Explorer Prion infectivity in the spleen of a PRNP heterozygous individual with subclinical variant Creutzfeldt-Jakob disease

J. Ironside, M. Bishop, J. Manson, 2017 .

Human tonsil-derived follicular dendritic-like cells are refractory to human prion infection in vitro and traffic disease-associated prion protein to lysosomes.

J. Ironside, J. Manson, P. D. De Sousa, 2014, The American journal of pathology.

No Adaptation of the Prion Strain in a Heterozygous Case of Variant Creutzfeldt-Jakob Disease

J. Manson, R. Will, G. Mackenzie, 2020, Emerging infectious diseases.

No adaption of the prion strain in a heterozygous case of variant Creutzfeldt-Jakob disease

J. Manson, R. Will, G. Mackenzie, 2020 .

Oral Prion Neuroinvasion Occurs Independently of PrPC Expression in the Gut Epithelium

A. Clarke, N. Mabbott, J. Manson, 2018, Journal of Virology.

A prion reduction filter does not completely remove endogenous prion infectivity from sheep blood

M. Turner, N. E. Appleford, J. Manson, 2015, Transfusion.

Increased susceptibility of transgenic mice expressing human PrP to experimental sheep bovine spongiform encephalopathy is not due to increased agent titre in sheep brain tissue

N. Hunter, J. Manson, R. Barron, 2014, The Journal of general virology.

Increased susceptibility of transgenic mice expressing human PrP to experimental sheep BSE is not due to increased agent titre in sheep brain tissue

N. Hunter, J. Manson, R. Barron, 2014 .

Constant Transmission Properties of Variant Creutzfeldt-Jakob Disease in 5 Countries

C. V. van Duijn, F. Tagliavini, L. Schonberger, 2012, Emerging infectious diseases.

Increased Susceptibility of Human-PrP Transgenic Mice to Bovine Spongiform Encephalopathy Infection following Passage in Sheep

N. Hunter, A. Chong, J. Foster, 2010, Journal of Virology.

Glycosylation of PrPC Determines Timing of Neuroinvasion and Targeting in the Brain following Transmissible Spongiform Encephalopathy Infection by a Peripheral Route

K. Brown, J. Manson, E. Cancellotti, 2010, Journal of Virology.

A gene-targeted mouse model of P102L Gerstmann-Sträussler-Scheinker syndrome.

J. Manson, R. Barron, 2003, Clinics in laboratory medicine.

Strain Typing of Prion Diseases Using In Vivo Mouse Models.

J. Manson, A. Diack, A. Boyle, 2017, Methods in molecular biology.

Variably Protease-Sensitive Prionopathy, a Unique Prion Variant with Inefficient Transmission Properties

J. Ironside, J. Manson, D. Ritchie, 2014, Emerging infectious diseases.

A novel erythroid-specific marker of transmissible spongiform encephalopathies

G. Miele, J. Manson, M. Clinton, 2001, Nature Medicine.

Mice with gene targetted prion protein alterations show that Prnp, Sine and Prni are congruent

Richard C. Moore, I. Mcconnell, J. Selfridge, 1998, Nature Genetics.

Differential expression of erythroid genes in prion disease.

J. Fazakerley, J. Hopkins, G. Miele, 2007, Biochemical and biophysical research communications.

MM2‐Thalamic Creutzfeldt–Jakob Disease: Neuropathological, Biochemical and Transmission Studies Identify a Distinctive Prion Strain

J. Langeveld, F. Tagliavini, M. Bishop, 2012, Brain pathology.

The role of host PrP in Transmissible Spongiform Encephalopathies.

M. Bishop, J. Manson, E. Cancellotti, 2007, Biochimica et biophysica acta.

Predicting susceptibility and incubation time of human-to-human transmission of vCJD

J. Ironside, M. Bishop, J. Manson, 2005, The Lancet Neurology.

Increased levels of oxidative stress markers detected in the brains of mice devoid of prion protein

Mark A. Smith, David R. Brown, M. Sy, 2001, Journal of neurochemistry.

Dramatic Reduction of PrPC Level and Glycosylation in Peripheral Nerves following PrP Knock-Out from Schwann Cells Does Not Prevent Transmissible Spongiform Encephalopathy Neuroinvasion

J. Manson, E. Cancellotti, N. Tuzi, 2009, The Journal of Neuroscience.

Assessing the risk of Sheep BSE transmission to humans

N. Hunter, J. Foster, J. Manson, 2010 .

Autoregulation of interleukin 1 production

J. Symons, G. Duff, J. Manson, 1989, European journal of immunology.

Male infertility and DNA damage in Doppel knockout and prion protein/Doppel double-knockout mice.

J. Selfridge, D. Melton, P. Saunders, 2004, The American journal of pathology.

Sideroflexin 3 is an α-synuclein-dependent mitochondrial protein that regulates synaptic morphology

Inês S. Amorim, D. Lamont, T. Gillingwater, 2017, Journal of Cell Science.

Cellular pion protein regulates beta-secretase cleavage of the Alzheimers amyloid precurs protein.

N. Hooper, C. Eckman, J. Manson, 2007 .

PrP gene dosage and long term potentiation.

N. MacLeod, A. Clarke, J. Manson, 1995, Neurodegeneration : a journal for neurodegenerative disorders, neuroprotection, and neuroregeneration.

Gene expression changes during murine postnatal brain development

G. Miele, J. Manson, M. Clinton, 2000, Genome Biology.

Mechanism of PrP‐Amyloid Formation in Mice Without Transmissible Spongiform Encephalopathy

Emily V. Chambers, B. Ghetti, Declan King, 2012, Brain pathology.

Distribution of Misfolded Prion Protein Seeding Activity Alone Does Not Predict Regions of Neurodegeneration

V. Perry, T. Freeman, B. Caughey, 2016, PLoS biology.

Insights into Mechanisms of Chronic Neurodegeneration

J. Manson, R. Barron, P. Piccardo, 2016, International journal of molecular sciences.

Astrocyte‐specific expression of hamster prion protein (PrP) renders PrP knockout mice susceptible to hamster scrapie

L. Mucke, A. Aguzzi, B. Chesebro, 1997, The EMBO journal.

The Mechanisms of Prion Disease

J. Manson, A. Gill, James D. Alibhai, 2011 .

Elimination of false positives generated through PCR re-amplification of differential display cDNA.

G. Miele, J. Manson, M. Clinton, 1998, BioTechniques.

Pro-death NMDA receptor signaling is promoted by the GluN2B C-terminus independently of Dapk1

S. Grant, B. McColl, N. Komiyama, 2017, eLife.

Genetic and environmental factors modify bovine spongiform encephalopathy incubation period in mice

I. Jackson, I. Mcconnell, J. Manson, 2001, Proceedings of the National Academy of Sciences of the United States of America.

Conditional Deletion of Prnp Rescues Behavioral and Synaptic Deficits after Disease Onset in Transgenic Alzheimer's Disease

S. Strittmatter, A. Kaufman, J. Manson, 2017, The Journal of Neuroscience.

Defining the Microglia Response during the Time Course of Chronic Neurodegeneration

B. McColl, T. Freeman, Kathleen Grabert, 2015, Journal of Virology.

Post‐translational changes to PrP alter transmissible spongiform encephalopathy strain properties

R. Somerville, J. Manson, S. Mahal, 2013, The EMBO journal.

The cellular prion protein binds copper in vivo

D. Westaway, P. Fraser, A. Giese, 1997, Nature.

Chronic wasting disease and atypical forms of bovine spongiform encephalopathy and scrapie are not transmissible to mice expressing wild-type levels of human prion protein.

Marco Sbriccoli, Maurizio Pocchiari, Cristina Casalone, 2012, The Journal of general virology.

Mechanisms of Cell Death in the Transmissible Spongiform Encephalopathies

J. Manson, A. Gill, James D. Alibhai, 2012 .

J. De Pedro-Cuesta, J. Manson, R. Will, 2017, Emerging infectious diseases.

Ablation of Prion Protein in Wild Type Human Amyloid Precursor Protein (APP) Transgenic Mice Does Not Alter The Proteolysis of APP, Levels of Amyloid-β or Pathologic Phenotype

N. Hooper, K. Kellett, J. Manson, 2016, PloS one.

Prion Protein Interacts with BACE1 Protein and Differentially Regulates Its Activity toward Wild Type and Swedish Mutant Amyloid Precursor Protein*

N. Hooper, K. Kellett, J. Manson, 2011, The Journal of Biological Chemistry.

Changing a single amino acid in the N‐terminus of murine PrP alters TSE incubation time across three species barriers

D. Melton, J. Ironside, J. Manson, 2001, The EMBO journal.

A single amino acid alteration (101L) introduced into murine PrP dramatically alters incubation time of transmissible spongiform encephalopathy

I. Mcconnell, D. Melton, J. Hope, 1999, The EMBO journal.

PRNP contains both intronic and upstream regulatory regions that may influence susceptibility to Creutzfeldt-Jakob Disease.

J. Ironside, J. Manson, R. Will, 2002, Gene.

Prion infectivity in the spleen of a PRNP heterozygous individual with subclinical variant Creutzfeldt–Jakob disease

J. Ironside, M. Bishop, J. Manson, 2013, Brain : a journal of neurology.

Variant CJD

J. Ironside, J. Manson, R. Will, 2014, Journal of the Neurological Sciences.

Accumulation of prion protein in the brain that is not associated with transmissible disease

B. Ghetti, Declan King, J. Manson, 2007, Proceedings of the National Academy of Sciences.

In vitro amplification and detection of variant Creutzfeldt–Jakob disease PrPSc

C. Prowse, J. Ironside, J. Manson, 2007, The Journal of pathology.

Prion protein expression in different species: analysis with a panel of new mAbs.

S. Hornemann, R. Glockshuber, S. Ferrari, 1998, Proceedings of the National Academy of Sciences of the United States of America.

Spermine increases acetylation of tubulins and facilitates autophagic degradation of prion aggregates

V. Macrae, J. Manson, K. Phadwal, 2018, Scientific Reports.

Altered circadian activity rhythms and sleep in mice devoid of prion protein

P. Achermann, T. Rülicke, T. Deboer, 1996, Nature.

PrP gene dosage determines the timing but not the final intensity or distribution of lesions in scrapie pathology.

I. Mcconnell, A. Clarke, J. Manson, 1994, Neurodegeneration : a journal for neurodegenerative disorders, neuroprotection, and neuroregeneration.

Human stem cell–derived astrocytes replicate human prions in a PRNP genotype–dependent manner

S. Chandran, Robert Krencik, E. Ullian, 2017, The Journal of experimental medicine.

Identification of a homology-independent linchpin domain controlling mouse and bank vole prion protein conversion

S. Supattapone, Geoffrey P. Noble, J. Manson, 2020, PLoS pathogens.

Molecular Model of Prion Transmission to Humans

C. Prowse, J. Ironside, J. Manson, 2009, Emerging infectious diseases.

4 Mechanisms of Cell Death in the Transmissible Spongiform Encephalopathies

J. Manson, A. Gill, James D. Alibhai, 2012 .

The scrapie fibril protein and its cellular isoform.

J. Manson, J. Hope, 1991, Current topics in microbiology and immunology.

Understanding transmission of the prion diseases.

J. Manson, Jean C Manson, 1999, Trends in microbiology.

The priori protein gene: a role in mouse embryogenesis?

M. Kaufman, J. Manson, J. West, 2005 .

Anti-prions and other agents

J. Manson, J. Hope, 1991, Nature.

Ablation of cellular prion protein expression affects mitochondrial numbers and morphology.

D. Turnbull, G. Miele, J. Manson, 2002, Biochemical and biophysical research communications.

Altered Glycosylated PrP Proteins Can Have Different Neuronal Trafficking in Brain but Do Not Acquire Scrapie-like Properties*

P. Monaghan, J. Manson, E. Cancellotti, 2005, Journal of Biological Chemistry.

Unravelling the glial response in the pathogenesis of Alzheimer's disease

J. Manson, James D. Alibhai, A. Diack, 2018, FASEB journal : official publication of the Federation of American Societies for Experimental Biology.

Mice devoid of prion protein have cognitive deficits that are rescued by reconstitution of PrP in neurons

S. Henriksen, B. Chesebro, J. Criado, 2005, Neurobiology of Disease.

Cellular Prion Protein Expression Is Not Regulated by the Alzheimer's Amyloid Precursor Protein Intracellular Domain

N. Hooper, J. Manson, V. Lewis, 2012, PloS one.

Variant CJD: Lessons in public health

J. Manson, R. Will, A. Rábano, 2016 .

Minimise transmission risk of CJD and vCJD in healthcare settings. Report on the Prevention of CJD and vCJD by Advisory Committee on Dangerous Pathogens' Transmission Spongiform Encephalopathy (ACDP TSE) Subgroup.

D. Jeffries, R. Cumming, A. Fraise, 2015 .

Variant CJD strain remains stable after secondary transmission

M. Bishop, J. Manson, E. Cancellotti, 2010 .

The impact of viral infection on the innate immune response within the brain during chronic neurodegeneration

T. Freeman, J. Fazakerley, R. Fragkoudis, 2013 .

Influenza A virus infection contributes to Parkinson's disease by driving pathological CD4(+) T cell responses in the brain

Yvonne Ligertwood, B. Dutia, A. Nash, 2013 .

All Clinically-Relevant Blood Components Transmit Prion Disease following a Single Blood Transfusion: A Sheep Model of vCJD

C. de Wolf, C. Prowse, N. Hunter, 2011, PloS one.

7 Knockouts, Transgenics, and Transplants in Prion Research

A. Aguzzi, A. Raeber, J. Manson, 1999 .

Disease-associated protein seeding suggests a dissociation between misfolded protein accumulation and neurodegeneration in prion disease

J. Manson, James D. Alibhai, A. Diack, 2017, Prion.

Cre‐loxP mediated control of PrP to study transmissible spongiform encephalopathy diseases

A. Clarke, J. Manson, N. Tuzi, 2004, Genesis.

Glycosylation and misfolding of PrP.

J. Manson, E. Cancellotti, F. Wiseman, 2005, Biochemical Society transactions.

Transgenic models of the transmissible spongiform encephalopathies

J. Manson, N. Tuzi, 2001, Expert Reviews in Molecular Medicine.

A rapid protocol for the authentication of isolated differential display RT-PCR CDNAs.

G. Miele, J. Manson, M. Clinton, 1999, Preparative biochemistry & biotechnology.

Tobler, I.et al. Altered circadian activity and sleep in mice devoid of prion protein. Nature 380, 639-642

P. Achermann, T. Rülicke, T. Deboer, 1996 .

Defining sporadic Creutzfeldt-Jakob disease strains and their transmission properties

M. Bishop, J. Manson, R. Will, 2010, Proceedings of the National Academy of Sciences of the United States of America.

Sideroflexin 3 is an α-synuclein-dependent mitochondrial protein that regulates synaptic morphology

Inês S. Amorim, D. Lamont, T. Gillingwater, 2017, Journal of Cell Science.

Variant CJD

J. Ironside, J. Manson, R. Will, 2014, Prion.

Follicular Dendritic Cell-Specific Prion Protein (PrPc) Expression Alone Is Sufficient to Sustain Prion Infection in the Spleen

K. Rajewsky, K. Brown, N. Mabbott, 2011, PLoS pathogens.

A prion reduction filter does not completely remove endogenous prion infectivity from sheep blood

M. Turner, N. E. Appleford, J. Manson, 2015, Transfusion.

Edinburgh Research Explorer Variant Creutzfeldt-Jakob Disease strain is identical in individuals of two PRNP codon 129 genotypes

M. Bishop, J. Manson, R. Will, 2022 .

Explorer Constant Transmission Properties of Variant Creutzfeldt-Jakob Disease in 5 Countries

F. Tagliavini, L. Schonberger, P. Gambetti, 2022 .

Codon 141 in ovine PRNP gene modulates incubation time in sheep orally infected with BSE

W. Goldmann, J. Manson, B. Tan, 2010 .

Pro-death NMDA receptor signaling is promoted by the GluN2B C-terminus independently of Dapk1

S. Grant, B. McColl, N. Komiyama, 2017, eLife.

Human tonsil-derived follicular dendritic-like cells are refractory to human prion infection in vitro and traffic disease-associated prion protein to lysosomes.

J. Ironside, J. Manson, P. D. De Sousa, 2014, The American journal of pathology.