D. Gray

发表

Characterization of Transgenic Mice with Targeted Disruption of the Catalytic Domain of the Double-stranded RNA-dependent Protein Kinase, PKR*

H. Atkins, N. Sonenberg, B. Vanderhyden, 1999, The Journal of Biological Chemistry.

Protective effect of vagotomy suggests source organ for Parkinson disease

D. Munoz, J. Woulfe, D. Gray, 2015, Annals of neurology.

Coordination of glioblastoma cell motility by PKCι

D. Gray, D. Parolin, I. Lorimer, 2010, Molecular Cancer.

Analysis of ubiquitination in vivo using a transgenic mouse model.

B. Vanderhyden, M. Dubé, D. Gray, 2001, BioTechniques.

Elevated expression of Unph, a proto-oncogene at 3p21.3, in human lung tumors.

R. Ueda, T. Takahashi, D. Gray, 1995, Oncogene.

Structural disorder and the loss of RNA homeostasis in aging and neurodegenerative disease

J. Woulfe, D. Gray, 2013, Front. Genet..

Damage control – a possible non‐proteolytic role for ubiquitin in limiting neurodegeneration

D. Gray, D. A. Gray, 2001, Neuropathology and applied neurobiology.

Lysine 63-Polyubiquitination Guards against Translesion Synthesis–Induced Mutations

P. Lambin, B. Wouters, D. Gray, 2006, PLoS genetics.

Expression of a K48R mutant ubiquitin protects mouse testis from cryptorchid injury and aging.

K. Boekelheide, D. Gray, R. Rasoulpour, 2003, The American journal of pathology.

Protease Activity in the Aging Brain

D. Gray, 2007 .

Lipofuscin and aging: a matter of toxic waste.

J. Woulfe, D. Gray, 2005, Science of aging knowledge environment : SAGE KE.

Ubiquitin C-terminal hydrolase L1 deletion ameliorates glomerular injury in mice with ACTN4-associated focal segmental glomerulosclerosis.

D. Gray, C. Holterman, C. Kennedy, 2014, Biochimica et biophysica acta.

NF-κB activation and polyubiquitin conjugation are required for pulmonary inflammation-induced diaphragm atrophy.

S. Shoelson, A. Schols, D. Gray, 2012, American journal of physiology. Lung cellular and molecular physiology.

Evolution of the highly networked deubiquitinating enzymes USP4, USP15, and USP11

X. Xia, D. Gray, C. Vlasschaert, 2015, BMC Evolutionary Biology.

Formation of lysine 63-linked poly-ubiquitin chains protects human lung cells against benzo[a]pyrene-diol-epoxide-induced mutagenicity.

P. Lambin, B. Wouters, R. Godschalk, 2007, DNA repair.

hMMS2 serves a redundant role in human PCNA polyubiquitination

W. Xiao, B. Wouters, D. Gray, 2008, BMC Molecular Biology.

Dysfunction of the Ubiquitin/Proteasome System and Mitochondria in Neurodegenerative Disease

D. Gray, M. Tang, 2012 .

Ubiquitin COOH-terminal hydrolase L1 deletion is associated with urinary α-klotho deficiency and perturbed phosphate homeostasis.

D. Gray, C. Holterman, C. Kennedy, 2018, American journal of physiology. Renal physiology.

Loss of UCHL1 promotes age-related degenerative changes in the enteric nervous system

J. Woulfe, D. Gray, Madison T. Gray, 2014, Front. Aging Neurosci..

Metformin Abrogates Age-Associated Ovarian Fibrosis

B. Vanderhyden, K. Rayner, J. Upham, 2019, Clinical Cancer Research.

Targeting the ubiquitin proteasome pathway for the treatment of septic shock in patients

D. Gray, J. Brun, 2009, Critical care.

Stimulation of the murine Uchl1 gene promoter by the B-Myb transcription factor.

D. Gray, Michael A. Long, M. Tsirigotis, 2003, Lung cancer.

Activation of int-1 and int-2 loci in GRf mammary tumors.

V. Morris, D. Gray, D. Percy, 1986, Virology.

STY, a tyrosine-phosphorylating enzyme with sequence homology to serine/threonine kinases

J. Bell, D. Gray, B. Howell, 1991, Molecular and cellular biology.

Effects of Mutant Ubiquitin on ts1 Retrovirus-Mediated Neuropathology

P. K. Wong, K. Reuhl, D. Gray, 2003, Journal of Virology.

Strategies for engineered negligible senescence.

D. Gray, 2003, Science of aging knowledge environment : SAGE KE.

Akt promotes chemoresistance in human ovarian cancer cells by modulating cisplatin-induced, p53-dependent ubiquitination of FLICE-like inhibitory protein

B. Tsang, M. Abedini, R. Bergeron, 2010, Oncogene.

Pulmonary inflammation-induced loss and subsequent recovery of skeletal muscle mass require functional poly-ubiquitin conjugation

M. Kelders, A. Schols, D. Gray, 2018, Respiratory Research.

A replication-competent promoter-trap retrovirus

D. Gray, J. Coulombe, Y. Avis, 1996, Journal of virology.

FUS‐Immunoreactive Intranuclear Inclusions in Neurodegenerative Disease

I. Mackenzie, J. Woulfe, D. Gray, 2010, Brain pathology.

The Evolution and Functional Diversification of the Deubiquitinating Enzyme Superfamily

X. Xia, D. Gray, C. Vlasschaert, 2017, Genome Biology and Evolution.

Selection preserves Ubiquitin Specific Protease 4 alternative exon skipping in therian mammals

X. Xia, D. Gray, C. Vlasschaert, 2016, Scientific Reports.

Genomic structure of Unp, a murine gene encoding a ubiquitin-specific protease.

R. Baker, D. Gray, C. Gilchrist, 1998, Biochimica et biophysica acta.

Protective Effects of Mutant Ubiquitin in Transgenic Mice

J. Woulfe, D. Gray, J. Brun, 2004, Annals of the New York Academy of Sciences.

Identification of a DNA region required for growth of Pseudomonas syringae pv. tomato on tomato plants

V. Morris, D. Gray, D. Cuppels, 1992 .

A common mouse mammary tumor virus integration site in chemically induced precancerous mammary hyperplasias.

V. Morris, D. Gray, C. Mcgrath, 1986, Virology.

Cisplatin induces p53-dependent FLICE-like inhibitory protein ubiquitination in ovarian cancer cells.

B. Tsang, M. Abedini, R. Bergeron, 2008, Cancer research.

Cisplatin Induces p 53-Dependent FLICE-Like Inhibitory Protein Ubiquitination in Ovarian Cancer Cells

B. Tsang, M. Abedini, R. Bergeron, 2008 .

Viewpoint Targeting the ubiquitin proteasome pathway for the treatment of septic shock in patients

D. Gray, J. Brun, 2009 .

Depletion of Beta Cell Intranuclear Rodlets in Human Type II Diabetes

J. Woulfe, D. Gray, F. Balaa, 2017, Endocrine Pathology.

ReportRegulation of PCNA polyubiquitination in human cells

B. Wouters, D. Gray, R. Chiu, 2015 .

Regulation of PCNA polyubiquitination in human cells

B. Wouters, D. Gray, R. Chiu, 2010, BMC Research Notes.

What deubiquitinating enzymes, oncogenes, and tumor suppressors actually do: Are current assumptions supported by patient outcomes?

D. Gray, Sophie Gregoire-Mitha, 2021, BioEssays : news and reviews in molecular, cellular and developmental biology.

Protection against murine osteoarthritis by inhibition of the 26S proteasome and lysine-48 linked ubiquitination

D. Gray, M. Radwan, A. Rowan, 2014, Annals of the rheumatic diseases.

Transgenic manipulation of the ubiquitin-proteasome system.

D. Gray, 2005, Essays in biochemistry.

Mutations in Transgenic Mice

R. Jaenisch, T. Noda, D. Gray, 1989 .

Hyperfiltration in ubiquitin C-terminal hydrolase L1-deleted mice.

L. D. Costa, C. H. Comin, R. Hébert, 2018, Clinical science.

Association of UNP, a ubiquitin-specific protease, with the pocket proteins pRb, p107 and p130

P. Blanchette, R. Baker, D. Gray, 2001, Oncogene.

Proviral inactivation of the Npat gene of Mpv 20 mice results in early embryonic arrest

R. Jaenisch, B. Vanderhyden, T. Shiomi, 1997, Molecular and cellular biology.

Insertional mutagenesis: neoplasia arising from retroviral integration.

D. Gray, 1991, Cancer investigation.

Developmental Mutations Generated by Retroviral Insertional Mutagenesis

R. Jaenisch, T. Noda, A. Sharpe, 1992 .

STY,aTyrosine-Phosphorylating EnzymewithSequence Homology toSerine/Threonine Kinases

D. Gray, P. L. Icely, J. Douville, 1991 .

The Unp proto-oncogene encodes a nuclear protein.

M. Chevrette, D. Gray, K. Gupta, 1994, Oncogene.

(ADP-ribose)n participates in DNA excision repair

B. Durkacz, D. Gray, S. Shall, 1980, Nature.

Hypothesis: a role for EBV-induced molecular mimicry in Parkinson's disease.

D. Munoz, J. Woulfe, Jaap M Middeldorp, 2014, Parkinsonism & related disorders.

Investigating Interventions in Alzheimer's Disease with Computer Simulation Models

Carole J. Proctor, Douglas A. Gray, James A. R. Nicoll, 2013, PloS one.

Activation of p38MAPK Contributes to Expanded Polyglutamine-Induced Cytotoxicity

Douglas A. Gray, Matthew Y. Tang, Maria Tsirigotis, 2008, PloS one.

Transgenic mouse model of kidney disease: Insertional inactivation of ubiquitously expressed gene leads to nephrotic syndrome

R. Jaenisch, T. Noda, A. Sharpe, 1990, Cell.

Poly(ADP‐ribose) polymerase activity in nucleotide permeable cells

D. Gray, S. Shall, H. Halldórsson, 1978, FEBS letters.

VIVA1: a more invasive subclone of MDA-MB-134VI invasive lobular carcinoma cells with increased metastatic potential in xenograft models

B. Vanderhyden, M. Clemons, C. Addison, 2022, British Journal of Cancer.

SIRT1 is a Highly Networked Protein That Mediates the Adaptation to Chronic Physiological Stress.

M. McBurney, D. Gray, K. Clark-Knowles, 2013, Genes & cancer.

Reversible modulation of SIRT1 activity in a mouse strain

Danielle Dewar-Darch, M. McBurney, D. Gray, 2017, PloS one.

Maneuvering for advantage: the genetics of mouse susceptibility to virus infection

N. Beauchemin, K. Dimock, S. Vidal, 2003, Trends in Genetics.

Nuclear IMPDH Filaments in Human Gliomas.

J. Woulfe, E. Engle, D. Gray, 2021, Journal of neuropathology and experimental neurology.

Alpha‐synuclein in the appendiceal mucosa of neurologically intact subjects

D. Munoz, J. Woulfe, D. Gray, 2014, Movement disorders : official journal of the Movement Disorder Society.

Explaining oscillations and variability in the p53-Mdm2 system

Carole J. Proctor, Douglas A. Gray, C. Proctor, 2008, BMC Systems Biology.

GSK3 and p53 - is there a link in Alzheimer's disease?

Carole J Proctor, C. Proctor, D. Gray, 2010, Molecular Neurodegeneration.

Unp, a mouse gene related to the tre oncogene.

N. Copeland, D. Gilbert, N. Jenkins, 1993, Oncogene.

Restriction endonuclease map of endogenous mouse mammary tumor virus loci in GR, DBA, and NFS mice.

V. Morris, D. Gray, J. MacInnes, 1986, Virology.

Mouse mammary tumor virus DNA sequences in tumorigenic and nontumorigenic cells from a mammary adenocarcinoma.

V. Morris, D. Gray, E. Chan, 1982, Virology.

Ubiquitin-Specific Proteases 4 and 15

D. Gray, 2013 .

A Ubiquitin-specific Protease That Efficiently Cleaves the Ubiquitin-Proline Bond*

R. Baker, D. Gray, C. Gilchrist, 1997, The Journal of Biological Chemistry.

Characterization of Int-5, a locus associated with early events in mammary carcinogenesis.

C. Kozak, V. Morris, D. Gray, 1991, Oncogene research.

Bone marrow–derived stem cells initiate pancreatic regeneration

Li Li, B. Strutt, D. Hess, 2003, Nature Biotechnology.

Deubiquitinating Enzymes in Model Systems and Therapy: Redundancy and Compensation Have Implications.

D. Gray, S. Zachariah, 2019, BioEssays : news and reviews in molecular, cellular and developmental biology.

Interference with ubiquitination causes oxidative damage and increased protein nitration: implications for neurodegenerative diseases

B. Halliwell, D. Gray, P. Jenner, 2004, Journal of neurochemistry.

Differential cytotoxicity of deoxyguanosine and 8‐aminoguanosine for human leukemic cell lines and normal bone marrow progenitor cells

A. Hoffbrand, R. Michalevicz, D. Gray, 1984, Hematological oncology.

Structure and heterogeneity of the a sequences of human herpesvirus 6 strain variants U1102 and Z29 and identification of human telomeric repeat sequences at the genomic termini

S. Dewhurst, D. Gray, B. Thomson, 1994, Journal of virology.

Human herpesvirus 6 (HHV-6) is a helper virus for adeno-associated virus type 2 (AAV-2) and the AAV-2 rep gene homologue in HHV-6 can mediate AAV-2 DNA replication and regulate gene expression.

R. Heilbronn, D. Gray, V. Schwaab, 1994, Virology.

An in silico model of the ubiquitin-proteasome system that incorporates normal homeostasis and age-related decline

Carole J. Proctor, Douglas A. Gray, Maria Tsirigotis, 2007, BMC Systems Biology.

OP-GBEV170021 1..16 ++

X. Xia, D. Gray, C. Vlasschaert, 2017 .

Experimental and Computational Analysis of Polyglutamine-Mediated Cytotoxicity

John Woulfe, Carole J. Proctor, Douglas A. Gray, 2010, PLoS Comput. Biol..

Engineering PTEN-L for Cell-Mediated Delivery

W. Stanford, D. Gray, C. Vlasschaert, 2017, Molecular therapy. Methods & clinical development.

Molecular analysis of the Mov 34 mutation: transcript disrupted by proviral integration in mice is conserved in Drosophila.

R. Jaenisch, D. Barton, U. Francke, 1990, Development.

Ubiquitin C-terminal hydrolase 1: A novel functional marker for liver myofibroblasts and a therapeutic target in chronic liver disease.

Caroline L. Wilson, N. Sheerin, D. Gray, 2015, Journal of hepatology.

AUnifying Hypothesis for Familial and Sporadic Alzheimer ’ s Disease

C. Proctor, D. Gray, 2014 .

A Unifying Hypothesis for Familial and Sporadic Alzheimer's Disease

Carole J. Proctor, Douglas A. Gray, C. Proctor, 2012, International journal of Alzheimer's disease.

Sensitivity of Mammalian Cells Expressing Mutant Ubiquitin to Protein-damaging Agents*

B. Wouters, D. Gray, R. Chiu, 2001, The Journal of Biological Chemistry.

Inhibitors of nuclear ADP‐ribosyl transferase retard DNA repair after N‐methyl‐N‐nitroso‐urea

B. Durkacz, D. Gray, S. Shall, 1981, FEBS letters.

Delayed spinocerebellar ataxia in transgenic mice expressing mutant ubiquitin

J. Woulfe, D. Gray, M Tsirigotis, 2006, Neuropathology and applied neurobiology.

Effect of ubiquitin expression on neuropathogenesis in a mouse model of familial amyotrophic lateral sclerosis

N. Gonatas, D. Gray, C. Gilchrist, 2005, Neuropathology and applied neurobiology.

Reply to: Alimentary, my dear Watson? The challenges of enteric α‐synuclein as a Parkinson's disease biomarker

J. Woulfe, D. Gray, Madison T. Gray, 2014, Movement disorders : official journal of the Movement Disorder Society.

Evolution of the highly networked deubiquitinating enzymes USP4, USP15, and USP11

X. Xia, D. Gray, C. Vlasschaert, 2015, BMC Evolutionary Biology.

Ubiquitin, proteasomes, and the aging brain.

John Woulfe, Maria Tsirigotis, J. Woulfe, 2003, Science of aging knowledge environment : SAGE KE.

An in silico model of the ubiquitin-proteasome system that incorporates normal homeostasis and age-related decline

D. Gray, M. Tsirigotis, C. Proctor, 2007, BMC Systems Biology.