D. Cavener

发表

The GCN2 eIF2α Kinase Is Required for Adaptation to Amino Acid Deprivation in Mice

S. Kimball, L. Jefferson, R. Wek, 2002, Molecular and Cellular Biology.

Ultrabithorax and Antennapedia 5' untranslated regions promote developmentally regulated internal translation initiation

D. Cavener, X. Ye, P. Fong, 1997, Molecular and cellular biology.

Brain ischemia and reperfusion activates the eukaryotic initiation factor 2α kinase, PERK

D. Ron, Rita Kumar, G. Krause, 2001, Journal of neurochemistry.

The Combined Effects of Tryptophan Starvation and Tryptophan Catabolites Down-Regulate T Cell Receptor ζ-Chain and Induce a Regulatory Phenotype in Naive T Cells1

U. Grohmann, M. L. Belladonna, C. Orabona, 2006, The Journal of Immunology.

PHOSPHOGLUCONATE DEHYDROGENASE IN DROSOPHILA

J. Williamson, D. Cavener, B. W. Geer, 1981 .

Dietary Modulation of Glucose-6-Phosphate Dehydrogenase and 6-Phosphogluconate Dehydrogenase in Drosophila

J. Williamson, D. Cavener, B. W. Geer, 1981 .

Eukaryotic start and stop translation sites.

D. Cavener, D R Cavener, S. C. Ray, 1991, Nucleic acids research.

Phosphorylation of the alpha subunit of eukaryotic initiation factor 2 is required for activation of NF-kappaB in response to diverse cellular stresses.

D. Scheuner, R. Kaufman, R. Wek, 2003, Molecular and cellular biology.

Endoplasmic Reticulum Stress Response Mediated by the PERK-eIF2α-ATF4 Pathway Is Involved in Osteoblast Differentiation Induced by BMP2*

A. Saito, D. Cavener, K. Imaizumi, 2010, The Journal of Biological Chemistry.

A mammalian homologue of GCN2 protein kinase important for translational control by phosphorylation of eukaryotic initiation factor-2alpha.

R. Sood, R. Wek, D. Cavener, 2000, Genetics.

Translation initiation in Drosophila melanogaster is reduced by mutations upstream of the AUG initiator codon

E. Organ, D. Cavener, Y. Feng, 1991 .

Seeing spots: Measuring, quantifying heritability, and assessing fitness consequences of coat pattern traits in a wild population of giraffes (Giraffa camelopardalis)

Derek E. Lee, D. Cavener, M. Bond, 2017, bioRxiv.

Rapid Turnover of the mTOR Complex 1 (mTORC1) Repressor REDD1 and Activation of mTORC1 Signaling following Inhibition of Protein Synthesis*

S. Kimball, L. Jefferson, D. Cavener, 2008, Journal of Biological Chemistry.

Perk Gene Dosage Regulates Glucose Homeostasis by Modulating Pancreatic β-Cell Functions

Barbara C. McGrath, D. Cavener, Siying Zhu, 2014, PloS one.

Insulin Secretion and Ca2+ Dynamics in β-Cells Are Regulated by PERK (EIF2AK3) in Concert with Calcineurin*

Barbara C. McGrath, D. Cavener, R. Kopp, 2013, The Journal of Biological Chemistry.

PERK regulates insulin secretion and Ca 2 + dynamics 1 Insulin secretion and Ca 2 + dynamics in β-cells are regulated by PERK eIF 2 α kinase in concert with calcineurin

Barbara C. McGrath, D. Cavener, R. Kopp, 2013 .

PERK (eIF2alpha kinase) is required to activate the stress-activated MAPKs and induce the expression of immediate-early genes upon disruption of ER calcium homoeostasis.

Wei Zhang, S. Liang, Peichuan Zhang, 2006, The Biochemical journal.

PERK is responsible for the increased phosphorylation of eIF2α and the severe inhibition of protein synthesis after transient global brain ischemia

Rita Kumar, G. Krause, Peichuan Zhang, 2005, Journal of neurochemistry.

COMMUNICATION Brain ischemia and reperfusion activates the eukaryotic initiation factor 2a kinase, PERK

D. Ron, Rita Kumar, G. Krause, 2001 .

Organ-specific patterns of gene expression in the reproductive tract of Drosophila are regulated by the sex-determination genes.

D. Cavener, Y. Feng, N. M. Schiff, 1991, Developmental biology.

in mouse liver mRNAs transcription and translation of distinct sets of kinases GCN2 and PERK modulate

S. Kimball, L. Jefferson, G. C. Henderson, 2015 .

Proinsulin Disulfide Maturation and Misfolding in the Endoplasmic Reticulum*

P. Arvan, Ming Liu, D. Cavener, 2005, Journal of Biological Chemistry.

1 Evolutionary analysis of vision genes identifies potential drivers of visual 2 differences between giraffe and okapi 3

M. Agaba, D. Cavener, E. Ishengoma, 2022 .

Isolation of genes encoding proteins of immunological importance.

D. Cavener, 1987, Methods in enzymology.

Induce a Regulatory Phenotype in Naive T-Chain and ζ DownRegulate T Cell Receptor Starvation and Tryptophan Catabolites The Combined Effects of Tryptophan Puccetti

U. Grohmann, M. L. Belladonna, C. Orabona, 2006 .

PERK eIF2alpha kinase regulates neonatal growth by controlling the expression of circulating insulin-like growth factor-I derived from the liver.

S. Liang, C. Rosen, Peichuan Zhang, 2003, Endocrinology.

PERK-dependent regulation of lipogenesis during mouse mammary gland development and adipocyte differentiation

C. Thompson, G. Hatzivassiliou, J. Diehl, 2008, Proceedings of the National Academy of Sciences.

A Mammalian Homologue of GCN 2 Protein Kinase Important for Translational Control by Phosphorylation of Eukaryotic Initiation Factor-2 a

R. Sood, R. Wek, D. Cavener, 2000 .

Using spot pattern recognition to examine population biology, evolutionary ecology, sociality, and movements of giraffes: a 70-year retrospective

Derek E. Lee, D. Cavener, M. Bond, 2022, Mammalian Biology.

Translation initiation in Drosophila melanogaster is reduced by mutations upstream of the AUG initiator codon

E. Organ, D. Cavener, Y. Feng, 1991, Molecular and cellular biology.

Calcineurin Activity Is Increased in Charcot-Marie-Tooth 1B Demyelinating Neuropathy

P. Paez, R. Kaufman, L. Wrabetz, 2021, The Journal of Neuroscience.

Ablation of Perk in Schwann Cells Improves Myelination in the S63del Charcot-Marie-Tooth 1B Mouse

L. Wrabetz, D. Cavener, M. D'Antonio, 2016, The Journal of Neuroscience.

GCN2 regulates the CCAAT enhancer binding protein beta and hepatic gluconeogenesis.

Barbara C. McGrath, D. Cavener, Jingjie Hu, 2013, American journal of physiology. Endocrinology and metabolism.

Activating Transcription Factor 3 Is Integral to the Eukaryotic Initiation Factor 2 Kinase Stress Response

Tsonwin Hai, Xiaozhong Wang, D. Ron, 2004, Molecular and Cellular Biology.

Chronic granulomatous disease

D. Cavener, 1987, Nature.

Dynamics of correlated genetic systems. IV. Multilocus effects of ethanol stress environments.

M. Clegg, D. Cavener, 1978, Genetics.

Tryptophan catabolism generates autoimmune-preventive regulatory T cells.

U. Grohmann, M. L. Belladonna, C. Orabona, 2006, Transplant immunology.

EIF 2 AK 3 control of pancreatic b cell differentiation and proliferation is required for postnatal glucose homeostasis

Barbara C. McGrath, D. Cavener, Wei Zhang, 2022 .

Hyperthermia Induces the ER Stress Pathway

Sounak Gupta, Barbara C. McGrath, D. Cavener, 2011, PloS one.

Acute ablation of PERK results in ER dysfunctions followed by reduced insulin secretion and cell proliferation

Sounak Gupta, Barbara C. McGrath, D. Cavener, 2009, BMC Cell Biology.

Endoplasmic Reticulum Stress Sensor Protein Kinase R–Like Endoplasmic Reticulum Kinase (PERK) Protects Against Pressure Overload–Induced Heart Failure and Lung Remodeling

Xinli Hu, Huan Wang, Xin Xu, 2014, Hypertension.

The protein kinase PERK/EIF2AK3 regulates proinsulin processing not via protein synthesis but by controlling endoplasmic reticulum chaperones

Barbara C. McGrath, D. Cavener, M. Nicolino, 2018, The Journal of Biological Chemistry.

Ribosome binding protein GCN1 regulates the cell cycle and cell proliferation and is essential for the embryonic development of mice

Satoru Takahashi, K. Itoh, Masayuki Yamamoto, 2020, PLoS genetics.

GCN2 Protein Kinase Is Required to Activate Amino Acid Deprivation Responses in Mice Treated with the Anti-cancer Agent l-Asparaginase*

T. Anthony, R. Wek, D. Cavener, 2009, The Journal of Biological Chemistry.

Mutations at the Ser50 residue of translation factor eIF-2alpha dominantly affect developmental rate, body weight, and viability of Drosophila melanogaster.

E. Organ, D. Cavener, S. Qu, 1997, Gene expression.

Biphasic expression and function of glucose dehydrogenase in Drosophila melanogaster.

D. Cavener, R. MacIntyre, R. Macintyre, 1983, Proceedings of the National Academy of Sciences of the United States of America.

Genetics of male-specific glucose oxidase and the identification of other unusual hexose enzymes in Drosophila melanogaster

D. Cavener, 1980, Biochemical Genetics.

Evolutionary analysis of vision genes identifies potential drivers of visual differences between giraffe and okapi

M. Agaba, D. Cavener, E. Ishengoma, 2017, PeerJ.

BMC Cell Biology

C. Atreya, Barbara C. McGrath, D. Cavener, 2007 .

The Drosophila melanogaster stranded at second (sas) gene encodes a putative epidermal cell surface receptor required for larval development.

E. Organ, D. Cavener, S. Qu, 1992, Developmental biology.

Molecular structure and transformation of the glucose dehydrogenase gene in Drosophila melanogaster.

E. Organ, D. Cavener, D. Cox-Foster, 1988, Genetics.

New Ways of Initiating Translation in Eukaryotes?

M. Hentze, R. Jackson, O. Elroy-Stein, 2001, Molecular and Cellular Biology.

Comparison of the consensus sequence flanking translational start sites in Drosophila and vertebrates.

D. Cavener, D R Cavener, 1987, Nucleic acids research.

Isolation of the eclosion gene cluster and the developmental expression of the Gld gene in Drosophila melanogaster.

D. Cavener, R. Whetten, D. Cox, 1986, The EMBO journal.

GCN2 in the Brain Programs PPARγ2 and Triglyceride Storage in the Liver during Perinatal Development in Response to Maternal Dietary Fat

Barbara C. McGrath, D. Cavener, Jingjie Hu, 2013, PloS one.

THE GCN 2 EIF 2 ALPHA KINASE REGULATES LIPID AND GLUCOSE HOMEOSTASIS

D. Cavener, Gong Chen, Xu Xu, 2011 .

Expansion and evolution of insect GMC oxidoreductases

Wen-Ya Ko, D. Cavener, Xiaolong Yang, 2007, BMC Evolutionary Biology.

Suppression of eIF2 a kinases alleviates Alzheimer’s disease–related plasticity and memory deficits

E. Klann, D. Cavener, P. Pierre, 2013 .

Suppression of eIF2α kinases alleviates AD-related synaptic plasticity and spatial memory deficits

E. Klann, T. Ma, D. Cavener, 2013, Nature Neuroscience.

Phosphorylation of the α Subunit of Eukaryotic Initiation Factor 2 Is Required for Activation of NF-κB in Response to Diverse Cellular Stresses

D. Scheuner, R. Kaufman, R. Wek, 2003, Molecular and Cellular Biology.

eIF2alpha kinases GCN2 and PERK modulate transcription and translation of distinct sets of mRNAs in mouse liver.

S. Kimball, L. Jefferson, D. Cavener, 2009, Physiological genomics.

Uncharged tRNA and Sensing of Amino Acid Deficiency in Mammalian Piriform Cortex

T. Anthony, R. Wek, Barbara C. McGrath, 2005, Science.

MULTIGENIC RESPONSE TO ETHANOL IN DROSOPHILA MELANOGASTER

M. Clegg, D. Cavener, 1981, Evolution; international journal of organic evolution.

The PERK Eukaryotic Initiation Factor 2α Kinase Is Required for the Development of the Skeletal System, Postnatal Growth, and the Function and Viability of the Pancreas

Peichuan Zhang, Barbara C. McGrath, Jamie Reinert, 2002, Molecular and Cellular Biology.

Mutations in GLIS3 are responsible for a rare syndrome with neonatal diabetes mellitus and congenital hypothyroidism

C. Julier, C. Charon, C. Chelala, 2006, Nature Genetics.

Co-opting regulation bypass repair as a gene-correction strategy for monogenic diseases

Barbara C. McGrath, D. Cavener, Jingjie Hu, 2020, Molecular therapy : the journal of the American Society of Gene Therapy.

PERK EIF2AK3 control of pancreatic beta cell differentiation and proliferation is required for postnatal glucose homeostasis.

Barbara C. McGrath, D. Cavener, Wei Zhang, 2006, Cell metabolism.

Preservation of Liver Protein Synthesis during Dietary Leucine Deprivation Occurs at the Expense of Skeletal Muscle Mass in Mice Deleted for eIF2 Kinase GCN2*

T. Anthony, M. McNurlan, R. Wek, 2004, Journal of Biological Chemistry.

Isolation of the gene encoding the Drosophila melanogaster homolog of the Saccharomyces cerevisiae GCN2 eIF-2alpha kinase.

D. Chen, R. Wek, D. S. Olsen, 1998, Genetics.

The GCN2 eIF2alpha kinase regulates fatty-acid homeostasis in the liver during deprivation of an essential amino acid.

F. Guo, D. Cavener, 2007, Cell metabolism.

Diverse Cellular Stresses B in Response to κ for Activation of NF-Eukaryotic Initiation Factor 2 Is Required Subunit of α Phosphorylation of the

D. Scheuner, R. Kaufman, R. Wek, 2003 .

Evolution of the expression of the Gld gene in the reproductive tract of Drosophila.

D. Cavener, P. Krasney, Y. Feng, 1992, Molecular biology and evolution.

Transgenic animal studies on the evolution of genetic regulatory circuitries

D. Cavener, 1992, BioEssays : news and reviews in molecular, cellular and developmental biology.

Evolution of the glucose dehydrogenase gene in Drosophila.

D. Cavener, C. Carr, P. Krasney, 1990, Molecular biology and evolution.

Developmental expression of the glucose dehydrogenase gene in Drosophila melanogaster.

M. Murtha, D. Cavener, D. Cox-Foster, 1990, Genetics.

Evidence for biochemical and physiological differences between enzyme genotypes in Drosophila melanogaster.

M. Clegg, D. Cavener, 1981, Proceedings of the National Academy of Sciences of the United States of America.

J. Ross, D. Cavener, P. Fong, 1994, Developmental genetics.

Glucose dehydrogenase is required for normal sperm storage and utilization in female Drosophila melanogaster

D. Cavener, K. Iida, Kaori Iida, 2004, Journal of Experimental Biology.

The Response of Enzyme Polymorphisms to Developmental Rate Selection in DROSOPHILA MELANOGASTER.

D. Cavener, 1983, Genetics.

Seeing spots: quantifying mother-offspring similarity and assessing fitness consequences of coat pattern traits in a wild population of giraffes (Giraffa camelopardalis)

Derek E. Lee, D. Cavener, M. Bond, 2018, PeerJ.

Translational control and the unfolded protein response.

R. Wek, D. Cavener, 2007, Antioxidants & redox signaling.

Brain-specific disruption of the eIF2α kinase PERK decreases ATF4 expression and impairs behavioral flexibility.

E. Klann, H. Kaphzan, R. Wek, 2012, Cell reports.

The PERK arm of the unfolded protein response regulates satellite cell-mediated skeletal muscle regeneration

S. Whittemore, Ashok Kumar, Yann S. Gallot, 2017, eLife.

Dynamics of Correlated Genetic Systems. VII. Demographic Aspects of Sex-Linked Transmission

M. Clegg, D. Cavener, 1982, The American Naturalist.

Binding analysis of the estrogen receptor to its specific DNA target site in human breast cancer.

F. Parl, B. Foster, D. Cavener, 1991, Cancer research.

PERK in beta cell biology and insulin biogenesis

Sounak Gupta, Barbara C. McGrath, D. Cavener, 2010, Trends in Endocrinology & Metabolism.

25-Hydroxycholesterol Activates the Integrated Stress Response to Reprogram Transcription and Translation in Macrophages*

C. Glass, S. Subramaniam, M. Maurya, 2013, The Journal of Biological Chemistry.

Correction: PERK Regulates the Proliferation and Development of Insulin-Secreting Beta-Cell Tumors in the Endocrine Pancreas of Mice

Sounak Gupta, Barbara C. McGrath, D. Cavener, 2009, PLoS ONE.

PERK Regulates the Proliferation and Development of Insulin-Secreting Beta-Cell Tumors in the Endocrine Pancreas of Mice

Sounak Gupta, Barbara C. McGrath, D. Cavener, 2009, PloS one.

PERK promotes cancer cell proliferation and tumor growth by limiting oxidative DNA damage

Jiangbin Ye, C. Koumenis, J. Diehl, 2010, Oncogene.

Repression of the eIF2α kinase PERK alleviates mGluR-LTD impairments in a mouse model of Alzheimer's disease

E. Klann, Wenzhong Yang, Xueyan Zhou, 2016, Neurobiology of Aging.

Analysis of the PvuII restriction fragment-length polymorphism and exon structure of the estrogen receptor gene in breast cancer and peripheral blood.

W D Dupont, W. Dupont, F. Parl, 1992, Cancer research.

Temporal Stability of Allozyme Frequencies in a Natural Population of DROSOPHILA MELANOGASTER.

M. Clegg, D. Cavener, 1981, Genetics.

Genomic DNA analysis of the estrogen receptor gene in breast cancer

W. Dupont, F. Parl, D. Cavener, 1989, Breast Cancer Research and Treatment.

PERK Regulates Working Memory and Protein Synthesis-Dependent Memory Flexibility

Barbara C. McGrath, D. Cavener, Siying Zhu, 2016, PloS one.

Genetic inactivation of PERK signaling in mouse oligodendrocytes: Normal developmental myelination with increased susceptibility to inflammatory demyelination

B. Popko, D. Cavener, Y. Hussien, 2014, Glia.

PERK is essential for neonatal skeletal development to regulate osteoblast proliferation and differentiation

Barbara C. McGrath, D. Cavener, Daorong Feng, 2008, Journal of cellular physiology.

PERK regulates Gq protein-coupled intracellular Ca2+ dynamics in primary cortical neurons

Barbara C. McGrath, D. Cavener, Siying Zhu, 2016, Molecular Brain.

Ecdysteroid regulation of glucose dehydrogenase and alcohol dehydrogenase gene expression in Drosophila melanogaster.

M. Murtha, D. Cavener, 1989, Developmental biology.

The Pennsylvania State University The Graduate School Eberly College of Science COFILIN RODS AND NEURODEGENERATION

D. Cavener, Gong Chen, B. Luscher, 2009 .

Isolation and characterization of the Drosophila melanogaster gene encoding translation-initiation factor eIF-2β

D. Cavener, X. Ye, 1994 .

Isolation and characterization of the Drosophila melanogaster eIF-2 alpha gene encoding the alpha subunit of translation initiation factor eIF-2.

D. Cavener, S. Qu, 1994, Gene.

Detection of estrogen receptor mRNA in human uterus

F. Parl, D. Cavener, D. Cox, 1987, Molecular and Cellular Endocrinology.

A rehabilitation of the genetic map of the 84B-D region in Drosophila melanogaster.

D. Otteson, T. Kaufman, D. Cavener, 1986, Genetics.

THE EFFECTS OF LEUCINE DEPRIVATION AND CALORIC RESTRICTION ON THE HUMAN METABOLISM

D. Cavener, Qing Wang, R. Cyr, 2010 .

PERK (EIF2AK3) Regulates Proinsulin Trafficking and Quality Control in the Secretory Pathway

Sounak Gupta, Barbara C. McGrath, D. Cavener, 2010, Diabetes.

Giraffe genome sequence reveals clues to its unique morphology and physiology

W. Miller, C. Praul, R. Chikhi, 2016, Nature Communications.

The eIF2α kinase PERK limits the expression of hippocampal metabotropic glutamate receptor-dependent long-term depression

E. Klann, H. Kaphzan, T. Ma, 2014, Learning & memory.

Preference for ethanol inDrosophila melanogaster associated with the alcohol dehydrogenase polymorphism

D. Cavener, Douglas Cavener, 1979, Behavior Genetics.

GMC oxidoreductases. A newly defined family of homologous proteins with diverse catalytic activities.

D. Cavener, D. Cavener, 1992, Journal of molecular biology.

Genetic connectivity and population structure of African savanna elephants (Loxodonta africana) in Tanzania

Barbara C. McGrath, D. Cavener, A. Estes, 2020, Ecology and evolution.

5 Nutrient signaling through mammalian GCN2

S. Kimball, L. Jefferson, T. Anthony, 2004 .

PERK regulates Gq protein-coupled intracellular Ca2+ dynamics in primary cortical neurons

Barbara C. McGrath, D. Cavener, Siying Zhu, 2016, Molecular Brain.

Coevolution of the glucose dehydrogenase gene and the ejaculatory duct in the genus Drosophila.

D. Cavener, 1985, Molecular biology and evolution.

Genetic evidence of population subdivision among Masai giraffes separated by the Gregory Rift Valley in Tanzania

Derek E. Lee, D. Cavener, M. Bond, 2023, Ecology and evolution.

Author response: The PERK arm of the unfolded protein response regulates satellite cell-mediated skeletal muscle regeneration

S. Whittemore, Yann S. Gallot, D. Cavener, 2017 .

Drosophila glucose dehydrogenase and yeast alcohol oxidase are homologous and share N-terminal homology with other flavoenzymes.

D. Cavener, P. Krasney, 1991, Molecular biology and evolution.

Masai giraffe population change over 40 years in Arusha National Park

D. Cavener, M. Bond, Derek E. Lee, 2023, African Journal of Ecology.

Masai giraffe population change over 40 years in Arusha National Park

Derek E. Lee, D. Cavener, M. Bond, 2023 .

Evolution of Developmental Regulation

D. Cavener, 1989, The American Naturalist.

PERK eIF2 alpha kinase is required to regulate the viability of the exocrine pancreas in mice

Barbara C. McGrath, D. Cavener, Yulin Li, 2007, BMC Cell Biology.

Combinatorial control of structural genes in Drosophila: Solutions that work for the animal

D. Cavener, 1987, BioEssays : news and reviews in molecular, cellular and developmental biology.

upstream of the AUG initiator codon. melanogaster is reduced by mutations Translation initiation in Drosophila

E. Organ, D. Cavener, L. E. Gunter, 2013 .

Suppression of eIF 2 α kinases alleviates AD-related synaptic plasticity and spatial memory deficits

E. Klann, T. Ma, D. Cavener, 2016 .

eIF2alpha kinases GCN2 and PERK modulate transcription and translation of distinct sets of mRNAs in mouse liver.

S. Kimball, L. Jefferson, D. Cavener, 2009, Physiological genomics.

Sleeping Beauty, Awake! Regulation of Insulin Gene Expression by Methylation of Histone H3

D. Cavener, 2009, Diabetes.

PERK promotes cancer cell proliferation and tumor growth by limiting oxidative DNA damage

C. Koumenis, J. Diehl, E. Bobrovnikova-Marjon, 2010, Oncogene.

MULTIGENIC RESPONSE TO ETHANOL IN DROSOPHILA MELANOGASTER

M. Clegg, D. Cavener, 1981, Evolution; international journal of organic evolution.

Response of theG6pd and6Pgd polymorphisms inDrosophila melanogaster to dietary selection

D. Cavener, 2004, Genetica.

Complex organization of promoter and enhancer elements regulate the tissue- and developmental stage-specific expression of the Drosophila melanogaster Gld gene.

D. Cavener, Y. Feng, J. Quine, 2001, Genetics.

Sexual dimorphisms in body proportions of Masai giraffes and the evolution of the giraffe’s neck

D. Cavener, M. Bond, Derek E. Lee, 2024, Mammalian Biology.

Heat shock effects on phosphorylation of protein synthesis initiation factor proteins eIF-4E and eIF-2 alpha in Drosophila.

D. Cavener, R. Duncan, S. Qu, 1995, Biochemistry.