Laura Hulea

发表

Targeting the translation machinery in cancer

N. Sonenberg, J. Pelletier, I. Topisirovic, 2015, Nature Reviews Drug Discovery.

nanoCAGE reveals 5′ UTR features that define specific modes of translation of functionally related MTOR-sensitive mRNAs

J. Pelletier, O. Larsson, Marie Cargnello, 2016, Genome research.

mTOR-sensitive translation: Cleared fog reveals more trees

O. Larsson, I. Topisirovic, L. Furic, 2017, RNA biology.

Mitochondrial complex IV defects induce metabolic and signaling perturbations that expose potential vulnerabilities in HCT116 cells

Alexander V. Zhdanov, P. Baranov, D. Andreev, 2022, FEBS open bio.

Autocrine Activation of the Wnt/β-Catenin Pathway by CUX1 and GLIS1 in Breast Cancers

M. Hallett, R. Lesurf, Morag Park, 2014, Biology Open.

PRDM15 is a key regulator of metabolism critical to sustain B-cell lymphomagenesis

Dachuan Huang, C. Ong, A. Jeyasekharan, 2020, Nature Communications.

Biomedical Potential of mTOR Modulation by Nanoparticles.

I. Topisirovic, Z. Marković, T. Simmet, 2016, Trends in biotechnology.

SBI-0640756 Attenuates the Growth of Clinically Unresponsive Melanomas by Disrupting the eIF4F Translation Initiation Complex.

K. Brown, M. Bosenberg, Z. Ronai, 2015, Cancer research.

EIF4A inhibition targets bioenergetic homeostasis in AML MOLM-14 cells in vitro and in vivo and synergizes with cytarabine and venetoclax

N. Johnson, Alexandre Orthwein, Laura Hulea, 2022, Journal of experimental & clinical cancer research : CR.

A hydride transfer complex reprograms NAD metabolism and bypasses senescence.

L. Kenner, G. Ferbeyre, J. Omichinski, 2021, Molecular cell.

mTOR coordinates protein synthesis, mitochondrial activity and proliferation

O. Larsson, M. Pollak, I. Topisirovic, 2015, Cell cycle.

mTOR Controls Mitochondrial Dynamics and Cell Survival via MTFP1.

H. McBride, N. Sonenberg, H. Vali, 2017, Molecular cell.

METTL13 Methylation of eEF1A Increases Translational Output to Promote Tumorigenesis

Joshua E. Elias, Capucine Van Rechem, A. Maitra, 2019, Cell.

Oncogenic kinases and perturbations in protein synthesis machinery and energetics in neoplasia

M. Pollak, I. Topisirovic, Laura Hulea, 2018, Journal of molecular endocrinology.

mTOR as a central regulator of lifespan and aging

Frédérick A. Mallette, L. Kazak, M. Pollak, 2019, F1000Research.

RAS Transformation Requires CUX1-Dependent Repair of Oxidative DNA Damage

M. Paquet, D. Dankort, A. Karnezis, 2014, PLoS biology.

Starvation-induced proteasome assemblies in the nucleus link amino acid supply to apoptosis

Frédérick A. Mallette, J. Masson, Mikhail Sergeev, 2021, Nature Communications.

Selective inhibitors of mTORC1 activate 4EBP1 and suppress tumor growth

G. Kiss, N. Rosen, Mallika Singh, 2021, Nature Chemical Biology.

The oncometabolite 2-hydroxyglutarate activates the mTOR signalling pathway

Frédérick A. Mallette, E. E. Vincent, Russell G. Jones, 2016, Nature Communications.

Translational and HIF1α-dependent metabolic reprograming underpin oncometabolome plasticity and synergy between oncogenic kinase inhibitors and biguanides

C. Greenwood, J. Ursini-Siegel, M. Ohh, 2017, bioRxiv.

Serine deprivation enhances antineoplastic activity of biguanides.

M. Pollak, I. Topisirovic, E. Birman, 2014, Cancer research.

Therapeutics , Targets , and Chemical Biology Serine Deprivation Enhances Antineoplastic Activity of Biguanides

M. Pollak, I. Topisirovic, E. Birman, 2014 .

CUX1 transcription factors: from biochemical activities and cell-based assays to mouse models and human diseases.

Laura Hulea, A. Nepveu, 2012, Gene.

CBFA2T3-GLIS2-dependent pediatric acute megakaryoblastic leukemia is driven by GLIS2 and sensitive to Navitoclax

Frédérick A. Mallette, J. Zuber, Laura Hulea, 2022, bioRxiv.

Translational and HIF-1α-Dependent Metabolic Reprogramming Underpin Metabolic Plasticity and Responses to Kinase Inhibitors and Biguanides.

C. Greenwood, E. Ma, Russell G. Jones, 2018, Cell metabolism.

Perturbations of cancer cell metabolism by the antidiabetic drug canagliflozin

M. Pollak, I. Topisirovic, Laura Hulea, 2021, Neoplasia.

Flaviviruses alter endoplasmic reticulum-mitochondria contacts to regulate respiration and apoptosis

A. Pichlmair, Laura Hulea, Laurent Chatel-Chaix, 2023, bioRxiv.

mTOR Controls Mitochond rial Dynamics and Cell Survival via MTFP 1 Graphical Abstract Highlights

H. McBride, N. Sonenberg, H. Vali, 2017 .

The mitochondrial pyruvate carrier complex potentiates the efficacy of proteasome inhibitors in multiple myeloma

Alexandre Orthwein, E. Taylor, I. Topisirovic, 2023, Blood advances.

CUX1 transcription factors: from biochemical activities and cell-based assays to mouse models and human diseases.

Laura Hulea, A. Nepveu, 2012, Gene.

Translational and HIF1α-dependent metabolic reprograming underpin oncometabolome plasticity and synergy between oncogenic kinase inhibitors and biguanides

C. Greenwood, M. Ohh, O. Larsson, 2017, bioRxiv.

ZO-1 interacts with YB-1 in endothelial cells to regulate stress granule formation during angiogenesis

S. Angers, J. Gratton, I. Topisirovic, 2024, Nature communications.