Hong Wang

发表

Structural Determinants of PERK Inhibitor Potency and Selectivity

D. Ron, Jaime D. Blais, Hong Wang, 2010, Chemical biology & drug design.

Can the Energy Gap in the Protein-Ligand Binding Energy Landscape Be Used as a Descriptor in Virtual Ligand Screening?

Hong Wang, T. Cardozo, Hong Wang, 2012, PloS one.

Discovery and optimization of a novel spiropyrrolidine inhibitor of β-secretase (BACE1) through fragment-based drug design.

M. Mansour, J. Pandit, BinQing Wei, 2012, Journal of medicinal chemistry.

Design, Synthesis, and Biological Evaluation of New Cathepsin B-Sensitive Camptothecin Nanoparticles Equipped with a Novel Multifuctional Linker.

Yan-fen Fang, Wei Lu, Hong Wang, 2016, Bioconjugate chemistry.

Synthesis and fluorescence properties of 5,7-diphenylquinoline and 2,5,7-triphenylquinoline derived from m-terphenylamine.

Hong Wang, S. Qi, Kehui Shi, 2007, Molecules.

Structural basis for AMPK activation: natural and synthetic ligands regulate kinase activity from opposite poles by different molecular mechanisms.

R. Kurumbail, M. Harris, Hong Wang, 2014, Structure.

Discovery of 1-arylcarbonyl-6,7-dimethoxyisoquinoline derivatives as glutamine fructose-6-phosphate amidotransferase (GFAT) inhibitors.

S. So, Shaoqing Chen, Nam T Le, 2011, Bioorganic & medicinal chemistry letters.

L-4, a Well-Tolerated and Orally Active Inhibitor of Hedgehog Pathway, Exhibited Potent Anti-tumor Effects Against Medulloblastoma in vitro and in vivo

Yan-fen Fang, T. Zhu, Hong Wang, 2019, Front. Pharmacol..

Synthesis and evaluation of novel dimethylpyridazine derivatives as hedgehog signaling pathway inhibitors.

Hong Wang, Xiongwen Zhang, Weili Zhao, 2018, Bioorganic & medicinal chemistry.

Molecular basis for the MacroD1-mediated hydrolysis of ADP-ribosylation

Xiaochun Yu, Chen Wu, Hong Wang, 2020, DNA Repair.

Synthesis and preliminary cytotoxicity study of a cephalosporin-CC-1065 analogue prodrug

J. Larrick, Yuqiang Wang, Hong Wang, 2001, BMC chemical biology.

2-[(3aR,4R,5S,7aS)-5-{(1S)-1-[3,5-bis(trifluoromethyl)phenyl]-2-hydroxyethoxy}-4-(2-methylphenyl)octahydro-2H-isoindol-2-yl]-1,3-oxazol-4(5H)-one: a potent human NK1 receptor antagonist with multiple clearance pathways.

L. Gantert, R. DeVita, R. Hargreaves, 2013, Journal of medicinal chemistry.

Activation of CPP 32-like Proteases Is Not Sufficient to Trigger Apoptosis : Inhibition of Apoptosis by Agents that Suppress Activation of AP 24 , but Not CPP 32-like Activity

J. Larrick, Hong Wang, S. C. Wright, 1997 .

Activation of CPP32-like Proteases Is Not Sufficient to Trigger Apoptosis: Inhibition of Apoptosis by Agents that Suppress Activation of AP24, but Not CPP32-like Activity

J. Larrick, Hong Wang, S. C. Wright, 1997, The Journal of experimental medicine.

A New Series of Cytotoxic Pyrazoline Derivatives as Potential Anticancer Agents that Induce Cell Cycle Arrest and Apoptosis

Cheng Chen, Hong Wang, Duncan Wei, 2017, Molecules.

cis-2,5-dicyanopyrrolidine inhibitors of dipeptidyl peptidase IV: synthesis and in vitro, in vivo, and X-ray crystallographic characterization.

M. Ammirati, D. Danley, S. Wright, 2006, Journal of medicinal chemistry.

Synthesis and preliminary cytotoxicity study of glucuronide derivatives of CC-1065 analogues.

J. Larrick, Yuqiang Wang, Hong Wang, 2003, Bioorganic & medicinal chemistry.

CC-1065 analogues bearing different DNA-binding subunits: synthesis, antitumor activity, and preliminary toxicity study.

J. Larrick, Yuqiang Wang, Hong Wang, 2003, Journal of medicinal chemistry.

Synthesis and cytotoxicity of a biotinylated CC-1065 analogue

J. Larrick, Yuqiang Wang, Hong Wang, 2002, BMC chemical biology.

Glycomimetic ligands for the human asialoglycoprotein receptor.

David A. Price, M. Finn, J. Pfefferkorn, 2012, Journal of the American Chemical Society.

Structural Characterization of Proline-rich Tyrosine Kinase 2 (PYK2) Reveals a Unique (DFG-out) Conformation and Enables Inhibitor Design

Leonard Buckbinder, Daniel P. Walker, L. Buckbinder, 2009, Journal of Biological Chemistry.

Discovery of Brain-Penetrant, Irreversible Kynurenine Aminotransferase II Inhibitors for Schizophrenia.

J. Pandit, Ji-Young Kim, M. Hayward, 2012, ACS medicinal chemistry letters.

Synthesis and Evaluation of New Pyrazoline Derivatives as Potential Anticancer Agents in HepG-2 Cell Line

Cheng Chen, Hong Wang, Duncan Wei, 2017, Molecules.

Triazolo[4,5-d]pyrimidines as Validated General Control Nonderepressible 2 (GCN2) Protein Kinase Inhibitors Reduce Growth of Leukemia Cells

H. Ryoo, R. Tibes, Hong Wang, 2018, Computational and structural biotechnology journal.

Crystal structure of nicotinic acid mononucleotide adenylyltransferase from Staphyloccocus aureus: structural basis for NaAD interaction in functional dimer.

D. Danley, Hong Wang, Seungil Han, 2006, Journal of molecular biology.

Structural basis for AMPK activation: natural and synthetic ligands regulate kinase activity from opposite poles by different molecular mechanisms.

R. Kurumbail, M. Harris, Hong Wang, 2014, Structure.

Activation of CPP32-like Proteases Is Not Sufficient to Trigger Apoptosis: Inhibition of Apoptosis by Agents that Suppress Activation of AP24, but Not CPP32-like Activity

J. Larrick, Hong Wang, S. C. Wright, 1997, The Journal of experimental medicine.

Glycomimetic ligands for the human asialoglycoprotein receptor.

M. Finn, J. Pfefferkorn, Hong Wang, 2012, Journal of the American Chemical Society.