W. Hol

发表

An accurate numerical model for calculating the equilibration rate of a hanging-drop experiment.

D J Diller, D. Diller, W. Hol, 1999, Acta crystallographica. Section D, Biological crystallography.

Selective inhibition of trypanosomal glyceraldehyde-3-phosphate dehydrogenase by protein structure-based design: toward new drugs for the treatment of sleeping sickness.

F. Opperdoes, C. Verlinde, P. Herdewijn, 1994, Journal of medicinal chemistry.

Synthesis and structure-activity relationships of analogs of 2'-deoxy-2'-(3-methoxybenzamido)adenosine, a selective inhibitor of trypanosomal glycosomal glyceraldehyde-3-phosphate dehydrogenase.

P. Herdewijn, S. van Calenbergh, J. Rozenski, 1995, Journal of medicinal chemistry.

Using a Galactose Library for Exploration of a Novel Hydrophobic Pocket in the Receptor Binding Site of the Escherichia coliHeat-labile Enterotoxin*

C. Verlinde, W. Hol, W. Hol, 1999, The Journal of Biological Chemistry.

A mutant cholera toxin B subunit that binds GM1- ganglioside but lacks immunomodulatory or toxic activity

E. Merritt, W. Lencer, T. Hirst, 2001, Proceedings of the National Academy of Sciences of the United States of America.

Removal of Escherichia coli in wastewater by activated sludge

C. Stumm, W. Hol, C. Drift, 1977, Applied and environmental microbiology.

Structural foundation for the design of receptor antagonists targeting Escherichia coli heat-labile enterotoxin.

E A Merritt, E. Merritt, W. Hol, 1997, Structure.

A flash-annealing technique to improve diffraction limits and lower mosaicity in crystals of glycerol kinase.

Joanne I. Yeh, W. Hol, 1998, Acta crystallographica. Section D, Biological crystallography.

A genetically detoxified derivative of heat-labile Escherichia coli enterotoxin induces neutralizing antibodies against the A subunit

R. Rappuoli, M. Pizza, M. Giuliani, 1994, The Journal of experimental medicine.

RoleofGM,binding inthemucosal immunogenicity andadjuvant activity ofthe Escherichia coli heat-labile enterotoxin anditsBsubunit

L. DeHaan, J. Wilschut, M. Holtrop, 1998 .

Intermolecular interactions between the A and B subunits of heat-labile enterotoxin from Escherichia coli promote holotoxin assembly and stability in vivo.

T. Sixma, T. Hirst, S. Streatfield, 1992, Proceedings of the National Academy of Sciences of the United States of America.

Structure-based drug design: progress, results and challenges.

C L Verlinde, W G Hol, C. Verlinde, 1994, Structure.

INTERACTION OF PYROPHOSPHATE MOIETIES WITH ALPHA-HELIXES IN DINUCLEOTIDE BINDING-PROTEINS

R. Wierenga, M. de Maeyer, W. Hol, 1985 .

Anion binding at the active site of trypanosomal triosephosphate isomerase. Monohydrogen phosphate does not mimic sulphate.

C L Verlinde, M. Noble, C. Verlinde, 1991, European journal of biochemistry.

Dihydrofolate reductase from Lactobacillus casei. X-ray structure of the enzyme methotrexate.NADPH complex.

N. Xuong, J. Bolin, D. Filman, 1978, Journal of Biological Chemistry.

The coenzyme analogue adenosine 5-diphosphoribose displaces FAD in the active site of p-hydroxybenzoate hydroxylase. An x-ray crystallographic investigation.

J. Drenth, R. Wierenga, W. Hol, 1989, Biochemistry.

Crystal structure of the p-hydroxybenzoate hydroxylase-substrate complex refined at 1.9 A resolution. Analysis of the enzyme-substrate and enzyme-product complexes.

G Vriend, K S Wilson, G. Vriend, 1989, Journal of molecular biology.

Solid-phase synthesis of N-acyl-N'-alkyl/aryl disubstituted guanidines.

A. Ghosh, W. Hol, E. Fan, 2001, The Journal of organic chemistry.

Glycolysis as a target for the design of new anti-trypanosome drugs.

C L Verlinde, F. Opperdoes, M. Gelb, 2001, Drug resistance updates : reviews and commentaries in antimicrobial and anticancer chemotherapy.

Refined 1.83 A structure of trypanosomal triosephosphate isomerase crystallized in the presence of 2.4 M-ammonium sulphate. A comparison with the structure of the trypanosomal triosephosphate isomerase-glycerol-3-phosphate complex.

G Vriend, G. Vriend, M. Noble, 1991, Journal of molecular biology.

Prediction of the occurrence of the ADP-binding beta alpha beta-fold in proteins, using an amino acid sequence fingerprint.

P. Terpstra, R. Wierenga, W. Hol, 1986, Journal of molecular biology.

Structure determination of the glycosomal triosephosphate isomerase from Trypanosoma brucei brucei at 2.4 A resolution.

K. H. Kalk, R. Wierenga, W. Hol, 1987, Journal of molecular biology.

The role of waters in docking strategies with incremental flexibility for carbohydrate derivatives: heat-labile enterotoxin, a multivalent test case.

C L Verlinde, D J Diller, C. Verlinde, 1999, Journal of medicinal chemistry.

Preliminary crystallographic studies of glycosomal glyceraldehyde phosphate dehydrogenase from Trypanosoma brucei brucei.

R J Read, F. Opperdoes, R. Read, 1987, Journal of molecular biology.

Structure-based exploration of the ganglioside GM1 binding sites of Escherichia coli heat-labile enterotoxin and cholera toxin for the discovery of receptor antagonists.

C L Verlinde, C. Verlinde, W. Hol, 1999, Biochemistry.

Crystallographic and molecular modeling studies on trypanosomal triosephosphate isomerase: a critical assessment of the predicted and observed structures of the complex with 2-phosphoglycerate.

C L Verlinde, M. Noble, C. Verlinde, 1991, Journal of medicinal chemistry.

Synthesis and Conformational Analysis of 2′-Deoxy-2′-(3-methoxybenzamido)adenosine, a Rational-Designed Inhibitor of Trypanosomal Glyceraldehyde Phosphate Dehydrogenase (GAPDH).

P. Herdewijn, J. Rozenski, A. Aerschot, 1994 .