J. Sutherland

发表

The salt dependence of DNA recognition by NF-kappaB p50: a detailed kinetic analysis of the effects on affinityand specificity.

D. Hart, R. Speight, M. Cooper, 1999, Nucleic acids research.

Towards an evolutionary theory of the origin of life based on kinetics and thermodynamics

J. Sutherland, R. Pascal, A. Pross, 2013, Open Biology.

Synthesis of Cytidine Ribonucleotides by Stepwise Assembly of the Heterocycle on a Sugar Phosphate

B. Hayter, J. Sutherland, Abdul-Aziz Ingar, 2003, Chembiochem : a European journal of chemical biology.

Synthesis of potentially prebiotic RNA precursors: Cytosine and guanine derivatives

J. Sutherland, J. Whitfield, 1997 .

Prebiotic synthesis of simple sugars by photoredox systems chemistry.

J. Sutherland, John D Sutherland, Dougal J. Ritson, 2012, Nature chemistry.

A new plasmid display technology for the in vitro selection of functional phenotype-genotype linked proteins.

D. Hart, R. Speight, J. Sutherland, 2001, Chemistry & biology.

Purification and characterization of cloned isopenicillin N synthetase.

J. Sutherland, N. Turner, A. Willis, 1987, The Journal of antibiotics.

Analysis of the conversion of δ-(l-α-aminoadipoyl)-l-cysteinyl-d-α-aminobutyrate by active-site mutants of Aspergillus nidulans isopenicillin N synthase

C. Rowe, J. Sutherland, T. Claridge, 1998 .

A practical method for the combinatorial synthesis of peptide aldehydes

J. Sutherland, B. J. Hall, 1998 .

Photoredox chemistry in the synthesis of 2-aminoazoles implicated in prebiotic nucleic acid synthesis† †Electronic supplementary information (ESI) available. CCDC 2024098. For ESI and crystallographic data in CIF or other electronic format see DOI: 10.1039/d0cc05752e

Long-Fei Wu, A. Bond, J. Sutherland, 2020, Chemical communications.

Acyl coenzyme A: 6‐aminopenicillanic acid acyltransferase from Penicillium chrysogenum and Aspergillus nidulans

C. Schofield, J. Sutherland, J. Baldwin, 1990, FEBS letters.

Supply of phosphate to early Earth by photogeochemistry after meteoritic weathering

S. Mojzsis, J. Sutherland, Dougal J. Ritson, 2020, Nature Geoscience.

Structural basis for the inhibition of the SARS-CoV-2 RNA-dependent RNA polymerase by favipiravir-RTP

D. Barford, D. Kimanius, C. Russo, 2020, bioRxiv.

UV-light-driven prebiotic synthesis of iron-sulfur clusters.

J. Szostak, D. Sasselov, S. Mansy, 2017, Nature chemistry.

Prebiotic Chemistry: A Bioorganic Perspective

J. Sutherland, J. Whitfield, 1997 .

Oxidation of primary bile acids by a 7 alpha-hydroxysteroid dehydrogenase elaborating Clostridium bifermentans soil isolate.

J. Sutherland, L. Holdeman, C. Williams, 1987, Canadian journal of microbiology.

Bile acid induction of 7 alpha- and 7 beta-hydroxysteroid dehydrogenases in Clostridium limosum.

J. Sutherland, C. Williams, 1985, Journal of lipid research.

Bile acid induction of 7a- and 76-hydroxysteroid dehydrogenases in Clostridium limosum

J. Sutherland, C. Williams, 1985 .

Formation of urso- and ursodeoxy-cholic acids from primary bile acids by a Clostridium limosum soil isolate.

J. Sutherland, L. Holdeman, C. Williams, 1984, Journal of lipid research.

The metabolism of primary, 7-oxo, and 7 beta-hydroxy bile acids by Clostridium absonum.

J. Sutherland, I. Macdonald, 1982, Journal of lipid research.

Effect of bile acid oxazoline derivatives on microorganisms participating in 7 alpha-hydroxyl epimerization of primary bile acids.

J. Sutherland, E. Mosbach, I. Macdonald, 1983, Journal of lipid research.

Further studies on the bile salt induction of 7 alpha- and 7 beta-hydroxysteroid dehydrogenases in Clostridium absonum.

J. Sutherland, I. Macdonald, Ian A. MacDonald, 1983, Biochimica et biophysica acta.

Site-specific forced misincorporation mutagenesis using modified T7 DNA polymerase.

S. Martin, J. Sutherland, J. Baldwin, 1991, Protein engineering.

Killing two birds with one stone : a chemically plausible 05 s r + scheme for linked nucleic acid replication and coded Qf # 2 ; , & # i peptide synthesis

J. Sutherland, J. Blackburn, 2004 .

Tuning the reactivity of nitriles using Cu(ii) catalysis – potentially prebiotic activation of nucleotides

Long-Fei Wu, D. Murphy, J. Sutherland, 2018, Chemical science.

Expeditious, potentially primordial, aminoacylation of nucleotides.

J. Sutherland, R. Pascal, J. Biron, 2005, Angewandte Chemie.

Exploratory Studies to Investigate a Linked Prebiotic Origin of RNA and Coded Peptides. 3rd Communication

J. Sutherland, K. Ace, 2004, Chemistry & biodiversity.

Illuminating Life’s Origins: UV Photochemistry in Abiotic Synthesis of Biomolecules

J. Sutherland, Nicholas J. Green, Jianfeng Xu, 2021, Journal of the American Chemical Society.

The enzymic and chemical synthesis of ursodeoxycholic and chenodeoxycholic acid from cholic acid.

J. Sutherland, T. P. Forrest, I. Macdonald, 1982, Preparative biochemistry.

Exploratory Studies to Investigate a Linked Prebiotic Origin of RNA and Coded Peptides

Tony Cox, J. Sutherland, Vinciane Borsenberger, 2004, Chemistry & biodiversity.

Synthesis of activated pyrimidine ribonucleotides in prebiotically plausible conditions

J. Sutherland, M. Powner, Matthew W. Powner, 2009, Nature.

Azoles as Auxiliaries and Intermediates in Prebiotic Nucleoside Synthesis

A. Bond, J. Sutherland, M. Popławski, 2022, Journal of the American Chemical Society.

Cyanamide as a prebiotic phosphate activating agent – catalysis by simple 2-oxoacid salts

J. Sutherland, Maria Tsanakopoulou, 2017, Chemical communications.

A new and potentially prebiotic α-cytidine derivative

A. Bond, J. Sutherland, Jianfeng Xu, 2017, Chemical communications.

Mixed Anhydride Intermediates in the Reaction of 5(4H)‐Oxazolones with Phosphate Esters and Nucleotides

J. Sutherland, R. Pascal, Ziwei Liu, 2016, Chemistry.

Conversion of Biosynthetic Precursors of RNA to Those of DNA by Photoredox Chemistry

J. Sutherland, Dougal J. Ritson, 2014, Journal of Molecular Evolution.

Phosphate-mediated interconversion of ribo- and arabino-configured prebiotic nucleotide intermediates.

J. Sutherland, M. Powner, 2010, Angewandte Chemie.

On the Prebiotic Synthesis of Ribonucleotides: Photoanomerisation of Cytosine Nucleosides and Nucleotides Revisited

J. Sutherland, J. Raftery, M. Powner, 2007, Chembiochem : a European journal of chemical biology.

An approach to prevent aggregation during the purification and crystallization of wild type acyl coenzyme A: isopenicillin N acyltransferase from Penicillium chrysogenum.

D. Hart, B. Dijkstra, H. Yoshida, 2005, Protein expression and purification.

Length-Selective Synthesis of Acylglycerol-Phosphates through Energy-Dissipative Cycling

J. Sutherland, C. Caumes, Claudia Percivalle, 2019, Journal of the American Chemical Society.

Novel stereochemical manipulations of the penicillin nucleus

J. Sutherland, J. Baldwin, Robert Y. Chan, 1994 .

Potentially Prebiotic Synthesis of Aminoacyl-RNA via a Bridging Phosphoramidate-Ester Intermediate

J. Sutherland, Ziwei Liu, Samuel J. Roberts, 2022, bioRxiv.

Solid-Phase Synthesis and Hybrization Behavior of Partially 2′/3′-O-Acetylated RNA Oligonucleotides

Christopher K. W. Chan, J. Sutherland, Jianfeng Xu, 2014, The Journal of organic chemistry.

Simultaneous nucleotide activation and synthesis of amino acid amides by a potentially prebiotic multi-component reaction.

J. Sutherland, John D Sutherland, Lee B Mullen, 2007, Angewandte Chemie.

Chemoselective Multicomponent One-Pot Assembly of Purine Precursors in Water

J. Szostak, J. Sutherland, M. Powner, 2010, Journal of the American Chemical Society.

A heuristic approach to the analysis of enzymic catalysis: reaction of delta-(L-alpha-aminoadipoyl)-L-cysteinyl-D-alpha-aminobutyrate and delta-(L-alpha-aminoadipoyl)-L-cysteinyl-D-allylglycine catalyzed by isopenicillin N synthase isozymes.

J. Sutherland, J. Blackburn, J. Baldwin, 1995, Biochemistry.

Aldolisation of Bis(glycolaldehyde) Phosphate and Formaldehyde

J. Sutherland, James M. Smith, 2005, Chembiochem : a European journal of chemical biology.

A Light-Releasable Potentially Prebiotic Nucleotide Activating Agent

D. A. Russell, David A Russell, D. Russell, 2018, Journal of the American Chemical Society.

Photochemical reductive homologation of hydrogen cyanide using sulfite and ferrocyanide† †Electronic supplementary information (ESI) available. See DOI: 10.1039/c8cc01499j

D. Sasselov, J. Sutherland, S. Ranjan, 2018, Chemical communications.

Provisioning the origin and early evolution of life

Long-Fei Wu, J. Sutherland, Long-Fei Wu, 2019, Emerging topics in life sciences.

Direct interplay between stereochemistry and conformational preferences in aminoacylated oligoribonucleotides

J. Sutherland, A. Polyansky, B. Žagrović, 2019, Nucleic acids research.

Opinion: Studies on the origin of life — the end of the beginning

J. Sutherland, 2017 .

Mimicking the surface and prebiotic chemistry of early Earth using flow chemistry

S. Ley, J. Sutherland, C. Battilocchio, 2018, Nature Communications.

Detection of Potential TNA and RNA Nucleoside Precursors in a Prebiotic Mixture by Pure Shift Diffusion-Ordered NMR Spectroscopy

M. Nilsson, G. Morris, J. Aguilar, 2013, Chemistry.

Reduction of Δ1-pyrroline-2-carboxylic acid to proline by an escherichia coli proline auxotroph.

M. Wright, C. Rowe, J. Sutherland, 1993 .

Directed evolution of novel biosynthetic pathways: growth of an escherichia coli proline auxotroph on Δ1-pyrroline-2-carboxylic acid.

M. Wright, J. Sutherland, E. Wilson, 1993 .

The effect of pH on the solution structure of Δ1-pyrroline-2-carboxylic acid as revealed by NMR and electrospray mass spectroscopy.

M. Wright, C. Rowe, J. Sutherland, 1993 .

A simple general synthesis of 2,4-dinitrophenyl glycopyranosides

M. Sinnott, J. Sutherland, D. Cocker, 1974 .

Exploratory Studies to Investigate a Linked Prebiotic Origin of RNA and Coded Peptides. 2nd Communication

J. Sutherland, Vinciane Borsenberger, J. Raftery, 2004, Chemistry & biodiversity.

Directed evolution of novel biosynthetic pathways: Overexpression of leucine aminopeptidase allows an Escherichia coli proline auxotroph to grow faster on prolinamide

J. Sutherland, E. Wilson, A. J. Little, 1994 .

Directed evolution of novel biosynthetic pathways: Construction of a randomly mutated gene library in an Escherichia coli proline auxotroph and selection for growth on potential proline precursors

M. Wright, J. Sutherland, E. Wilson, 1994 .

SYNTHESIS AND SOLUTION STRUCTURES OF AMINOACYL COMPOUNDS OF POTENTIAL PREBIOTIC SIGNIFICANCE

J. Sutherland, S. D. Cook, 1998 .

Studies on the reactivity of bisglycoaldehyde phosphodiester in alkaline solution

J. Sutherland, S. D. Cook, 1996 .

Solution structures of bis(glycoaldehyde) phosphodiester and mixed glycoaldehyde-triose phosphodiesters

J. Sutherland, G. Weaver, 1994 .

Exploratory Studies to Investigate a Linked Prebiotic Origin of RNA and Coded Peptides. 4th Communication

J. Sutherland, J. Raftery, M. Helliwell, 2005, Chemistry & biodiversity.

Studies on a potentially prebiotic synthesis of RNA

J. Sutherland, G. Weaver, 1997 .

The Origin of Life--Out of the Blue.

J. Sutherland, John D Sutherland, 2016, Angewandte Chemie.

RNA: Prebiotic Product, or Biotic Invention?

Alastair L Parkes, J. Sutherland, John D Sutherland, 2007, Chemistry & biodiversity.

Direct assembly of nucleoside precursors from two- and three-carbon units.

J. Sutherland, John D Sutherland, M. Powner, 2006, Angewandte Chemie.

Reaction of Cytidine Nucleotides with Cyanoacetylene: Support for the Intermediacy of Nucleoside‐2′,3′‐cyclic Phosphates in the Prebiotic Synthesis of RNA

J. Sutherland, Michael A. Crowe, 2006, ChemBioChem.

Prebiotic phosphorylation of 2-thiouridine provides either nucleotides or DNA building blocks via photoreduction

J. Sutherland, R. Krishnamurthy, Nicholas J. Green, 2019, Nature Chemistry.

The search for a potentially prebiotic synthesis of nucleotides via arabinose-3-phosphate and its cyanamide derivative.

J. Sutherland, J. Raftery, M. Helliwell, 2008, Chemistry.

Prebiotically plausible oligoribonucleotide ligation facilitated by chemoselective acetylation.

Christopher K. W. Chan, J. Sutherland, S. Islam, 2013, Nature chemistry.

Self-assembly of phosphate amphiphiles in mixtures of prebiotically plausible surfactants.

P. Monnard, J. Sutherland, A. Albertsen, 2014, Astrobiology.

Prebiotic Photochemical Coproduction of Purine Ribo- and Deoxyribonucleosides

D. A. Russell, D. Russell, J. Sutherland, 2021, Journal of the American Chemical Society.

Potentially Prebiotic Synthesis of Pyrimidine β‐D‐Ribonucleotides by Photoanomerization/Hydrolysis of α‐D‐Cytidine‐2′‐Phosphate

J. Sutherland, M. Powner, 2008, Chembiochem : a European journal of chemical biology.

Synthesis of potentially prebiotic RNA precursors: Adenine and uracil derivatives

J. Sutherland, G. Weaver, J. Whitfield, 1995 .

Common origins of RNA, protein and lipid precursors in a cyanosulfidic protometabolism.

Claudia Percivalle, J. Sutherland, Claudia Percivalle, 2015, Nature chemistry.

A stereoelectronic effect in prebiotic nucleotide synthesis.

R. Raines, K. Kamer, J. Sutherland, 2010, ACS chemical biology.

Formation of potentially prebiotic amphiphiles by reaction of beta-hydroxy-n-alkylamines with cyclotriphosphate.

J. Sutherland, Lee B Mullen, 2007, Angewandte Chemie.

Engineering of Penicillium chrysogenum for fermentative production of a novel carbamoylated cephem antibiotic precursor.

J. Pronk, J. Daran, A. K. Gombert, 2009, Metabolic engineering.

Mimicking the surface and prebiotic chemistry of early Earth using flow chemistry

S. Ley, J. Sutherland, C. Battilocchio, 2018, Nature Communications.

Prebiotic photoredox synthesis from carbon dioxide and sulfite

D. Sasselov, W. Fischer, Long-Fei Wu, 2021, Nature Chemistry.

Activation chemistry drives the emergence of functionalised protocells†

D. Russell, J. Sutherland, A. Mariani, 2020, Chemical science.

The chemical origins of life and its early evolution: an introduction

D. Lilley, J. Sutherland, 2011, Philosophical Transactions of the Royal Society B: Biological Sciences.

Structure of the SARS-CoV-2 RNA-dependent RNA polymerase in the presence of favipiravir-RTP

D. Barford, D. Kimanius, C. Russo, 2021, Proceedings of the National Academy of Sciences.

Structures of an isopenicillin N converting Ntn-hydrolase reveal different catalytic roles for the active site residues of precursor and mature enzyme.

B. Dijkstra, H. Yoshida, J. Sutherland, 2010, Structure.

An approach to prevent aggregation during the purification and crystallization of wild type acyl coenzyme A: Isopenicillin acyltransferase from

B. Dijkstra, D. W. Hart, H. Yoshida, 2005 .

Amino-acid substitutions in the cleavage site of acyl-coenzyme A:isopenicillin N acyltransferase from Penicillium chrysogenum: effect on proenzyme cleavage and activity.

J. Sutherland, M. Tobin, J. Baldwin, 1995, Gene.

Acyl-coenzyme A: isopenicillin N acyltransferase from Penicillium chrysogenum: effect of amino acid substitutions at Ser227, Ser230 and Ser309 on proenzyme cleavage and activity.

J. Sutherland, M. Tobin, J. Baldwin, 1994, FEMS microbiology letters.

The requirement for subunit interaction in the production of Penicillium chrysogenum acyl-coenzyme A:isopenicillin N acyltransferase in Escherichia coli.

J. Sutherland, P. Skatrud, M. Tobin, 1993, Gene.

On the production of α,β‐heterodimeric acyl‐coenzyme A: isopenicillin N‐acyltransferase of Penicillium chrysogenum

J. Sutherland, M. Tobin, J. Baldwin, 1993 .

Substrate ambiguity and catalytic promiscuity within a bacterial proteome probed by an easy phenotypic screen for aldehydes.

J. Sutherland, G. Krebs, Laure Hugonet, 2005, Angewandte Chemie.

Timescales for Prebiotic Photochemistry Under Realistic Surface Ultraviolet Conditions

D. A. Russell, D. Queloz, D. Russell, 2021, Astrobiology.

Sulfidic Anion Concentrations on Early Earth for Surficial Origins-of-Life Chemistry

D. Sasselov, J. Sutherland, S. Ranjan, 2018, Astrobiology.

pH-Driven RNA Strand Separation under Prebiotically Plausible Conditions

J. Sutherland, Christopher M. Johnson, A. Mariani, 2018, Biochemistry.

Purification, crystallization and preliminary X-ray diffraction of Cys103Ala acyl coenzyme A: isopenicillin N acyltransferase from Penicillium chrysogenum.

B. Dijkstra, J. Sutherland, C. Hensgens, 2002, Acta crystallographica. Section D, Biological crystallography.

High-level soluble expression of isopenicillin N synthase isozymes in E. coli

M. Wright, J. Sutherland, J. Blackburn, 1991 .

Evolutionary optimisation of enzymes.

J. Sutherland, J D Sutherland, 2000, Current opinion in chemical biology.

Antimalarial tetranortriterpenoids from the seeds of Lansium domesticum Corr.

J. Sutherland, K. Chantrapromma, N. Saewan, 2006, Phytochemistry.

The origin of RNA precursors on exoplanets

D. Queloz, E. Gillen, J. Sutherland, 2018, Science Advances.

The origin of life as a planetary phenomenon

J. Grotzinger, D. Sasselov, J. Sutherland, 2020, Science Advances.

Reduction of Δ1-pyrroline-2-carboxylic acid to proline in escherichia coli: lack of involvement of glutamate dehydrogenase and Δ1-pyrroline-5-carboxylate reductase.

M. Wright, C. Rowe, J. Sutherland, 1993 .

Selective prebiotic formation of RNA pyrimidine and DNA purine nucleosides

D. A. Russell, D. Russell, A. Bond, 2020, Nature.

Substrate specificity of cloned deacetoxycephalosporin C/deacetylcephalosporin C synthetase.

C. Schofield, J. Sutherland, J. Baldwin, 1988, The Journal of antibiotics.

Synthesis of Aldehydic Ribonucleotide and Amino Acid Precursors by Photoredox Chemistry

J. Sutherland, Dougal J. Ritson, 2013, Angewandte Chemie.

Estimation of ursodeoxycholic acid in human and bear biles using Clostridium absonum 7 beta-hydroxysteroid dehydrogenase.

J. Sutherland, C. Williams, I. Macdonald, 1983, Analytical biochemistry.

Prebiotic chemistry: a new modus operandi

J. Sutherland, John D Sutherland, M. Powner, 2011, Philosophical Transactions of the Royal Society B: Biological Sciences.

Catalyst Screening Using an Array of Thermistors.

J. Sutherland, Ashley R Connolly, John D Sutherland, 2000, Angewandte Chemie.

Template-Free Assembly of Functional RNAs by Loop-Closing Ligation

J. Szostak, J. Sutherland, Meng Su, 2022, Journal of the American Chemical Society.

Interstrand Aminoacyl Transfer in a tRNA Acceptor Stem-Overhang Mimic

J. Sutherland, Ziwei Liu, Meng-Yao Su, 2021, Journal of the American Chemical Society.

Excited-state hydrogen atom abstraction initiates the photochemistry of β-2′-deoxycytidine

J. Šponer, J. Šponer, J. Sutherland, 2015, Chemical science.

A prebiotically plausible synthesis of pyrimidine β-ribonucleosides and their phosphate derivatives involving photoanomerization.

Rafał Szabla, Judit E Šponer, J. Šponer, 2017, Nature chemistry.

Prebiotic Synthesis of N-Formylaminonitriles and Derivatives in Formamide

D. Russell, J. Sutherland, Nicholas J. Green, 2023, Journal of the American Chemical Society.

Substrate specificity of recombinant Streptomyces clavuligerus deacetoxycephalosporin C synthase.

I. Andersson, J. Sutherland, J. Baldwin, 1994 .

Substrate specificity of soluble recombinant deacetoxycephalosporin C/deacetylcephalosporin C synthase

R. Heath, J. Sutherland, J. Baldwin, 1992 .

The Origins of Nucleotides

J. Szostak, J. Sutherland, M. Powner, 2011 .

Non‐Enzymatic RNA Backbone Proofreading through Energy‐Dissipative Recycling

J. Sutherland, John D Sutherland, A. Mariani, 2017, Angewandte Chemie.

Conversion of Biosynthetic Precursors of RNA to Those of DNA by Photoredox Chemistry

J. Sutherland, Dougal J. Ritson, 2014, Journal of Molecular Evolution.

The origin of RNA precursors on exoplanets.

D. Queloz, E. Gillen, J. Sutherland, 2018, Science advances.

Nonenzymatic loop-closing ligation generates RNA hairpins and is a template-free way to assemble functional RNAs

J. Szostak, M. Su, J. Sutherland, 2021, bioRxiv.

Triplet-encoded prebiotic RNA aminoacylation

D. Wales, A. Jäschke, J. Sutherland, 2023, bioRxiv.

Harnessing chemical energy for the activation and joining of prebiotic building blocks

D. Russell, J. Sutherland, Jianfeng Xu, 2019, Nature Chemistry.

On the production of alpha, beta-heterodimeric acyl-coenzyme A: isopenicillin N-acyltransferase of Penicillium chrysogenum. Studies using a recombinant source.

J. Sutherland, R. Aplin, M. Tobin, 1993, FEBS letters.

Analysis of the NF-κB p50 dimer interface by diversity screening

D. Hart, R. Speight, J. Sutherland, 2001 .

Killing two birds with one stone: a chemically plausible scheme for linked nucleic acid replication and coded peptide synthesis.

J. Sutherland, J. Blackburn, 1997, Chemistry & biology.

UV-light-driven prebiotic synthesis of iron-sulfur clusters.

J. Szostak, D. Sasselov, S. Mansy, 2017, Nature chemistry.

Common origins of RNA, protein and lipid precursors in a cyanosulfidic protometabolism.

J. Sutherland, Claudia Percivalle, Dougal J. Ritson, 2015, Nature chemistry.

A novel cell-based scintillation proximity assay for studying protein function and activity in vitro using membrane-soluble scintillants.

A. Sutherland, J. Sutherland, J. Blackburn, 2002, Biochemical and biophysical research communications.

Mutational Analysis of the Kinetics and Thermodynamics of Transcription Factor NF‐κB Homodimerisation

J. Sutherland, J D Sutherland, J M Blackburn, 2002, Chembiochem : a European journal of chemical biology.