C. Löwik

发表

In vivo quantification of the scattering properties of tissue using multi-diameter single fiber reflectance spectroscopy

A. Amelink, H. S. de Bruijn, U. A. Gamm, 2013, Biomedical optics express.

Optical Image-Guided Cancer Surgery: Challenges and Limitations

A. Vahrmeijer, H. Sterenborg, R. J. Baatenburg de Jong, 2013, Clinical Cancer Research.

Whole-Body Optical Imaging in Animal Models to Assess Cancer Development and Progression

C. Löwik, E. Kaijzel, G. van der Pluijm, 2007, Clinical Cancer Research.

Multimodal imaging and treatment of bone metastasis

T. Snoeks, C. Löwik, E. Kaijzel, 2008, Clinical & Experimental Metastasis.

EGFR targeted nanobody–photosensitizer conjugates for photodynamic therapy in a pre-clinical model of head and neck cancer

H. S. de Bruijn, P. V. van Diest, C. V. D. van de Velde, 2016, Journal of controlled release : official journal of the Controlled Release Society.

Chapter 12:“In Vivo” Molecular Imaging

B. Lelieveldt, T. Snoeks, C. Löwik, 2010 .

Near-infrared fluorescence imaging of liver metastases in rats using indocyanine green.

H. Putter, P. Kuppen, C. V. D. van de Velde, 2012, The Journal of surgical research.

Near-Infrared Fluorescence Imaging in Patients Undergoing Pancreaticoduodenectomy

M. Hutteman, P. Kuppen, C. V. D. van de Velde, 2011, European Surgical Research.

Image-guided tumor resection using real-time near-infrared fluorescence in a syngeneic rat model of primary breast cancer

Jouke Dijkstra, Alexander L. Vahrmeijer, Ivo Que, 2011, Breast Cancer Research and Treatment.

Optical Image-guided Surgery—Where Do We Stand?

Alexander L. Vahrmeijer, Ivo Que, Cornelis J. H. van de Velde, 2010, Molecular Imaging and Biology.

Toward Optimization of Imaging System and Lymphatic Tracer for Near-Infrared Fluorescent Sentinel Lymph Node Mapping in Breast Cancer

Sylvain Gioux, Alan Stockdale, Hein Putter, 2011, Annals of Surgical Oncology.

Near-infrared fluorescence sentinel lymph node mapping of the oral cavity in head and neck cancer patients.

Cornelis J H van de Velde, Alexander L Vahrmeijer, John V Frangioni, 2013, Oral oncology.

Near‐infrared fluorescence‐guided resection of colorectal liver metastases

Cornelis J H van de Velde, Alexander L Vahrmeijer, John V Frangioni, 2013, Cancer.

Randomized, double-blind comparison of indocyanine green with or without albumin premixing for near-infrared fluorescence imaging of sentinel lymph nodes in breast cancer patients

Hein Putter, John V. Frangioni, Alexander L. Vahrmeijer, 2011, Breast Cancer Research and Treatment.

Intraoperative near-infrared fluorescence imaging of colorectal metastases targeting integrin α(v)β(3) expression in a syngeneic rat model.

M. Hutteman, H. Tanke, P. Kuppen, 2011, European journal of surgical oncology : the journal of the European Society of Surgical Oncology and the British Association of Surgical Oncology.

Optical Mammography Using Diffuse Optical Spectroscopy for Monitoring Tumor Response to Neoadjuvant Chemotherapy in Women with Locally Advanced Breast Cancer

Boudewijn P F Lelieveldt, Jouke Dijkstra, Cornelis J H van de Velde, 2014, Clinical Cancer Research.

Towards a Successful Clinical Implementation of Fluorescence-Guided Surgery

V. Ntziachristos, A. L. Vahrmeijer, C. W. G. M. Löwik, 2013, Molecular Imaging and Biology.

Environmental 24-hr Cycles Are Essential for Health

Johanna H. Meijer, J. Meijer, M. V. D. Velde, 2016, Current Biology.

Evaluating reporter genes of different luciferases for optimized in vivo bioluminescence imaging of transplanted neural stem cells in the brain.

Markus Aswendt, Mathias Hoehn, Laura Mezzanotte, 2013, Contrast media & molecular imaging.

‘In vivo’ optical approaches to angiogenesis imaging

C. W. G. M. Löwik, T. Snoeks, C. Löwik, 2010, Angiogenesis.

Click beetle luciferase mutant and near infrared naphthyl-luciferins for improved bioluminescence imaging

Yanto Ridwan, Ivo Que, Laura Mezzanotte, 2018, Nature Communications.

In vivo bioluminescence imaging of vascular remodeling after stroke

Mathias Hoehn, Ivo Que, Ernst Suidgeest, 2014, Front. Cell. Neurosci..

Degradation, intra-articular retention and biocompatibility of monospheres composed of [PDLLA-PEG-PDLLA]-b-PLLA multi-block copolymers.

H. Weinans, W. Hennink, N. Kops, 2017, Acta biomaterialia.

Interference with the microenvironmental support impairs the de novo formation of bone metastases in vivo.

Ivo Que, Antoinette Wetterwald, A. Wetterwald, 2005, Cancer research.

Chapter 7 BMP 7 , a Putative Regulator of Epithelial Homeostasis in the Human Prostate , is a Potent Inhibitor of Prostate Cancer Bone Metastasis In Vivo

S. Vukicevic, P. Dijke, F. Borovečki, 2009 .

Application of an in vitro model and a clinical protocol in the assessment of the potency of a new bisphosphonate

C. Löwik, S. Papapoulos, K. Hoekman, 1989, Journal of bone and mineral research : the official journal of the American Society for Bone and Mineral Research.

Ceramic hydroxyapatite implants for the release of bisphosphonate.

C. Löwik, S. Papapoulos, A. van den Hooff, 1994, Bone and mineral.

Necroptotic Cell Death in Liver Transplantation and Underlying Diseases: Mechanisms and Clinical Perspective

M. Verstegen, L. J. van der Laan, C. Löwik, 2019, Liver transplantation : official publication of the American Association for the Study of Liver Diseases and the International Liver Transplantation Society.

Regulation of parathyroid hormonelike protein production in cultured normal and malignant keratinocytes.

R. Offringa, M. Ponec, G. Hendy, 1992, The Journal of investigative dermatology.

Identification of receptor-type protein tyrosine phosphatase μ as a new marker for osteocytes

J. Waarsing, C. Löwik, E. Kaijzel, 2015, Histochemistry and Cell Biology.

Sclerostin: Current Knowledge and Future Perspectives

C. Löwik, S. Papapoulos, R. Van Bezooijen, 2010, Calcified Tissue International.

Microscopic analysis of the localization of two chlorin‐based photosensitizers in OSC19 tumors in the mouse oral cavity

H. S. de Bruijn, U. A. Gamm, A. Amelink, 2014, Lasers in surgery and medicine.

Antigen-adjuvant nanoconjugates for nasal vaccination: an improvement over the use of nanoparticles?

W. Jiskoot, J. Bouwstra, C. Löwik, 2010, Molecular pharmaceutics.

Pre-clinical Evaluation of a Cyanine-Based SPECT Probe for Multimodal Tumor Necrosis Imaging

R. Dacosta, T. Snoeks, C. Löwik, 2016, Molecular Imaging and Biology.

Effect of interleukin-17 on nitric oxide production and osteoclastic bone resorption: is there dependency on nuclear factor-kappaB and receptor activator of nuclear factor kappaB (RANK)/RANK ligand signaling?

C. Löwik, S. Papapoulos, R. Van Bezooijen, 2001, Bone.

Near Infrared Fluorescence Imaging for early detection, monitoring and improved intervention of diseases involving the joint

C. Löwik, M. D. Slooter, A. Chan, 2015, Connective tissue research.

Dissociation of Angiogenesis and Osteoclastogenesis During Endochondral Bone Formation in Neonatal Mice

A. Wetterwald, M. Cecchini, C. Löwik, 2002, Journal of bone and mineral research : the official journal of the American Society for Bone and Mineral Research.

Interleukin 17 synergises with tumour necrosis factor α to induce cartilage destruction in vitro

C. Löwik, S. Papapoulos, R. Van Bezooijen, 2002 .

Expression of estrogen receptors and enzymes involved in sex steroid metabolism in the rat tibia during sexual maturation.

J. Wit, M. Karperien, B. V. D. van der Eerden, 2004, The Journal of endocrinology.

Ovariectomy and orchidectomy induce a transient increase in the osteoclastogenic potential of bone marrow cells in the mouse.

C. Löwik, S. Papapoulos, A. Ederveen, 1997, Bone.

Alternative delivery of a thermostable inactivated polio vaccine.

Jean‐Pierre Amorij, G. Kersten, C. Löwik, 2015, Vaccine.

0021-972X/05/$15.00/0 The Journal of Clinical Endocrinology & Metabolism 90(12):6392–6395 Printed in U.S.A. Copyright © 2005 by The Endocrine Society doi: 10.1210/jc.2005-1235 Bone Mineral Density in Sclerosteosis; Affected Individuals and Gene Carriers

P. Beighton, C. Löwik, S. Papapoulos, 2022 .

Farnesyl pyrophosphate synthase is the molecular target of nitrogen-containing bisphosphonates.

E. Pieterman, C. Löwik, S. Papapoulos, 1999, Biochemical and biophysical research communications.

Plasma nitrate+nitrite levels are regulated by ovarian steroids but do not correlate with trabecular bone mineral density in rats.

C. Löwik, I. Que, S. Papapoulos, 1998, The Journal of endocrinology.

Inhibition of Gsk3β in cartilage induces osteoarthritic features through activation of the canonical Wnt signaling pathway.

J. Goeman, H. Weinans, L. Finos, 2011, Osteoarthritis and cartilage.

Ultrasound-mediated gene delivery of naked plasmid DNA in skeletal muscles: a case for bolus injections.

H. Grüll, C. Löwik, E. Kaijzel, 2014, Journal of controlled release : official journal of the Controlled Release Society.

Identification of a retinoic acid-inducible element in the murine PTH/PTHrP (parathyroid hormone/parathyroid hormone-related peptide) receptor gene.

B. Lanske, L. Defize, M. Karperien, 1999, Molecular endocrinology.

Active Nano-targeting of Macrophages.

C. Löwik, L. Mezzanotte, Natasa Gaspar, 2019, Current pharmaceutical design.

Sclerostin in Mineralized Matrices and van Buchem Disease

P. Hogendoorn, W. Hul, C. Löwik, 2009, Journal of dental research.

In Vivo Non-Invasive Tracking of Macrophage Recruitment to Experimental Stroke

M. Hoehn, A. Tennstaedt, C. Löwik, 2016, PloS one.

Adenomatous polyposis coli-mediated control of β-catenin is essential for both chondrogenic and osteogenic differentia- tion of skeletal precursors

R. Fodde, T. Kobayashi, J. Wit, 2011 .

Adenomatous polyposis coli-mediated control of β-catenin is essential for both chondrogenic and osteogenic differentiation of skeletal precursors

R. Fodde, J. Wit, H. Kronenberg, 2009, BMC Developmental Biology.

Chapter 4 Interference with the Microenvironment Support Impairs the De Novo Formation of Bone Metastasis In Vivo

A. Wetterwald, M. Cecchini, C. Löwik, 2009 .

CD40-targeted dendritic cell delivery of PLGA-nanoparticle vaccines induce potent anti-tumor responses.

S. H. van der Burg, J. Oostendorp, W. Jiskoot, 2015, Biomaterials.

VEGF and inhibitors of TGFβ type-I receptor kinase synergistically promote blood-vessel formation by inducing α5-integrin expression

M. Goumans, P. Dijke, T. van Laar, 2009, Journal of Cell Science.

Fluorinated PLGA-PEG-Mannose Nanoparticles for Tumor-Associated Macrophage Detection by Optical Imaging and MRI

U. Himmelreich, R. Censi, P. Di Martino, 2021, Frontiers in Medicine.

Control of bone mass by sclerostin: Inhibiting BMP- and WNT-induced bone formation

P. Dijke, C. Löwik, D. J. J. Gorter, 2008 .

Imaging Bioluminescent Exogenous Stem Cells in the Intact Guinea Pig Cochlea

M. Huisman, C. Löwik, L. Mezzanotte, 2019, Anatomical record.

uPAR-targeted multimodal tracer for pre- and intraoperative imaging in cancer surgery

F. Beekman, P. Kuppen, C. V. D. van de Velde, 2015, Oncotarget.

The Necrosis-Avid Small Molecule HQ4-DTPA as a Multimodal Imaging Agent for Monitoring Radiation Therapy-Induced Tumor Cell Death

R. Dacosta, T. Snoeks, C. Löwik, 2016, Front. Oncol..

Necrosis avid near infrared fluorescent cyanines for imaging cell death and their use to monitor therapeutic efficacy in mouse tumor models

M. Hoehn, V. Ntziachristos, D. Razansky, 2015, Oncotarget.

In Vivo Evaluation of Gallium-68-Labeled IRDye800CW as a Necrosis Avid Contrast Agent in Solid Tumors

Y. Seimbille, M. de Jong, Kranthi M Panth, 2021, Contrast media & molecular imaging.

Effective chemoimmunotherapy by co-delivery of doxorubicin and immune adjuvants in biodegradable nanoparticles

C. Löwik, F. Ossendorp, M. Camps, 2019, Theranostics.

The clinical use of indocyanine green as a near‐infrared fluorescent contrast agent for image‐guided oncologic surgery

Merlijn Hutteman, P. Kuppen, C. V. D. van de Velde, 2011, Journal of surgical oncology.

Novel Intraoperative Near-Infrared Fluorescence Camera System for Optical Image-Guided Cancer Surgery

Jouke Dijkstra, Alexander L. Vahrmeijer, Ivo Que, 2010, Molecular imaging.

Red-shifted click beetle luciferase mutant expands the multicolor bioluminescent palette for deep tissue imaging

L. Encell, Monika G. Wood, Y. Ridwan, 2020, iScience.

Transition of healthy to diseased synovial tissue in rheumatoid arthritis is associated with gain of mesenchymal/fibrotic characteristics

T. Huizinga, R. Toes, M. DeRuiter, 2006, Arthritis research & therapy.

Plaque Rupture Complications in Murine Atherosclerotic Vein Grafts Can Be Prevented by TIMP-1 Overexpression

J. Hamming, J. Jukema, P. Quax, 2012, PloS one.

Variations in surgical procedures for hind limb ischaemia mouse models result in differences in collateral formation.

J. Hamming, P. Quax, L. Seghers, 2010, European journal of vascular and endovascular surgery : the official journal of the European Society for Vascular Surgery.

Single and combined effects of αvβ3- and α5β1-integrins on capillary tube formation in a human fibrinous matrix

M. Engelse, V. V. van Hinsbergh, P. Koolwijk, 2009, Angiogenesis.

In vivo 808 nm image-guided photodynamic therapy based on an upconversion theranostic nanoplatform.

Yulei Chang, C. Löwik, Hong Zhang, 2015, Nanoscale.

Expression of the parathyroid hormone-related peptide gene in retinoic acid-induced differentiation: involvement of ETS and Sp1.

J. Boonstra, L. Defize, M. Karperien, 1997, Molecular endocrinology.

Bisphosphonates in osteoporosis?

R. Valkema, C. Löwik, S. Papapoulos, 2005, Osteoporosis International.

The use of bisphosphonates in the treatment of osteoporosis.

R. Valkema, E. Pauwels, C. Löwik, 1992, Bone.

Bone resorption and renal calcium reabsorption in renal cell carcinoma‐bearing mice: the effects of bisphosphonate

K. Kurth, D. Schamhart, C. Löwik, 2007, BJU international.

The Role of Geranylgeranylation in Bone Resorption and Its Suppression by Bisphosphonates in Fetal Bone Explants In Vitro: A Clue to the Mechanism of Action of Nitrogen‐Containing Bisphosphonates

C. Löwik, G. van der Pluijm, S. Papapoulos, 1999, Journal of bone and mineral research : the official journal of the American Society for Bone and Mineral Research.

SOST/Sclerostin: An Osteocyte-Derived Inhibitor of Bone Formation that Antagonizes Canonical Wnt Signaling

C. Löwik, S. Papapoulos, N. Hamdy, 2008 .

A two-receptor model for the action of parathyroid hormone on osteoblasts: a role for intracellular free calcium and cAMP.

J. V. van Leeuwen, C. Löwik, J. M. Meer, 1985, Cell calcium.

Effects of experimental conditions on the release of 45calcium from prelabeled fetal mouse long bones.

C. Löwik, S. Papapoulos, E. V. van Beek, 1995, Bone.

Development of a Multicolor Bioluminescence Imaging Platform to Simultaneously Investigate Transcription Factor NF-κB Signaling and Apoptosis.

M. Rabelink, C. Löwik, E. Kaijzel, 2016, Methods in molecular biology.

3 Atlas-Based Whole-Body Segmentation of Mice from Low-Contrast MicroCT Data

J. Milles, B. Lelieveldt, J. Reiber, 2011 .

In Vivo Fluorescence Imaging of IgG1 Aggregates After Subcutaneous and Intravenous Injection in Mice

W. Jiskoot, J. Carpenter, C. Löwik, 2013, Pharmaceutical Research.

Differentiation of murine preosteoblastic KS483 cells depends on autocrine bone morphogenetic protein signaling during all phases of osteoblast formation.

M. Karperien, C. Löwik, G. van der Horst, 2002, Bone.

Interleukin‐17: A New Bone Acting Cytokine In Vitro

C. Löwik, S. Papapoulos, R. Van Bezooijen, 1999, Journal of bone and mineral research : the official journal of the American Society for Bone and Mineral Research.

Two distinct effects of recombinant human tumor necrosis factor-alpha on osteoclast development and subsequent resorption of mineralized matrix.

C. Löwik, G. van der Pluijm, G. Pluijm, 1991, Endocrinology.

Investigative Urology: Hypercalcemia and Cosecretion of Interleukin-6 and Parathyroid Hormone Related Peptide by a Human Renal Cell Carcinoma Implanted Into Nude Mice

K. Kurth, D. Schamhart, P. Vos, 1995 .

Development of a Three-Dimensional In Vitro Model for Longitudinal Observation of Cell Behavior: Monitoring by Magnetic Resonance Imaging and Optical Imaging

M. Hoehn, T. Hilger, C. Löwik, 2009, Molecular Imaging and Biology.

A new paradigm in the treatment of osteoporosis: Wnt pathway proteins and their antagonists.

C. Löwik, A. Chan, R. Van Bezooijen, 2007, Current opinion in investigational drugs.

Integrins and osteoclastic resorption in three bone organ cultures: Differential sensitivity to synthetic arg‐gly‐asp peptides during osteoclast formation

C. Löwik, G. van der Pluijm, S. Papapoulos, 1994, Journal of bone and mineral research : the official journal of the American Society for Bone and Mineral Research.

Inhibition of terminal chondrocyte differentiation by bone morphogenetic protein 7 (OP-1) in vitro depends on the periarticular region but is independent of parathyroid hormone-related peptide.

E. Burger, B. Lanske, M. Karperien, 1999, Bone.

Interleukin 6/Wnt interactions in rheumatoid arthritis: interleukin 6 inhibits Wnt signaling in synovial fibroblasts and osteoblasts

S. Rose-John, R. Stoika, D. Baeten, 2016, Croatian medical journal.

ShRNA-mediated knockdown of interleukin-6 expression rescues tumor necrosis factor α-inhibited osteogenesis in mouse mesenchymal precursor cells

R. Stoika, D. Baeten, C. Löwik, 2015 .

IL‐1α, IL‐1β, IL‐6, and TNF‐α Steady‐State mRNA Levels Analyzed by Reverse Transcription‐Competitive PCR in Bone Marrow of Gonadectomized Mice

C. Löwik, S. Papapoulos, R. Van Bezooijen, 1998 .

A multi-modality platform to image stem cell graft survival in the naïve and stroke-damaged mouse brain.

M. Hoehn, M. Aswendt, J. Adamczak, 2014, Biomaterials.

Validation of a simple and fast method to quantify in vitro mineralization with fluorescent probes used in molecular imaging of bone.

I. Mol, C. Löwik, E. Kaijzel, 2014, Biochemical and biophysical research communications.

Endostatin's heparan sulfate-binding site is essential for inhibition of angiogenesis and enhances in situ binding to capillary-like structures in bone explants.

U. Felbor, B. Olsen, C. Löwik, 2005, Matrix biology : journal of the International Society for Matrix Biology.

Effect of Angiogenic and Antiangiogenic Compounds on the Outgrowth of Capillary Structures from Fetal Mouse Bone Explants

C. Löwik, G. Pluijm, S. Papapoulos, 2001, Laboratory Investigation.

First missense mutation in the SOST gene causing sclerosteosis by loss of sclerostin function

D. Adriaensen, T. Mueller, J. Timmermans, 2010, Human mutation.

Inhibition of intravacuolar acidification by antisense RNA decreases osteoclast differentiation and bone resorption in vitro.

C. Löwik, H. Väänänen, S. Papapoulos, 1999, Journal of cell science.

SOST expression is restricted to the great arteries during embryonic and neonatal cardiovascular development

C. Mummery, M. DeRuiter, P. Hogendoorn, 2007, Developmental dynamics : an official publication of the American Association of Anatomists.

Bisphosphonates suppress bone resorption by a direct effect on early osteoclast precursors without affecting the osteoclastogenic capacity of osteogenic cells: the role of protein geranylgeranylation in the action of nitrogen-containing bisphosphonates on osteoclast precursors.

C. Löwik, S. Papapoulos, E. V. van Beek, 2002, Bone.

Osteoclast formation together with interleukin-6 production in mouse long bones is increased by insulin-like growth factor-I.

C. Löwik, S. Papapoulos, L. Schot, 1992, The Journal of endocrinology.

Novel mutations in the parathyroid hormone (PTH)/PTH-related peptide receptor type 1 causing Blomstrand osteochondrodysplasia types I and II.

J. Wit, M. Karperien, C. Löwik, 2007, The Journal of clinical endocrinology and metabolism.

In vitro and in vivo endochondral bone formation models allow identification of anti-angiogenic compounds.

C. Löwik, A. Baxter, G. van der Pluijm, 2003, The American journal of pathology.

Parathyroid hormone (PTH) and PTH-like protein (PLP) stimulate interleukin-6 production by osteogenic cells: a possible role of interleukin-6 in osteoclastogenesis.

L. Aarden, C. Löwik, G. van der Pluijm, 1989, Biochemical and biophysical research communications.

Modulation of the production of a parathyroid hormone-like protein in human squamous carcinoma cell lines by interaction with fibroblasts.

M. Ponec, C. Löwik, K. Hoekman, 1990, Cancer research.

Expression of the parathyroid hormone-related peptide gene in retinoic acid-induced differentiation: involvement of ETS and Sp1.

J. Boonstra, L. Defize, M. Karperien, 1997, Molecular endocrinology.

Prolonged in vivo gene silencing by electroporation-mediated plasmid delivery of small interfering RNA.

R. Moon, P. Quax, J. H. van Bockel, 2007, Human gene therapy.

Quantification of adherent and nonadherent cells cultured in 96-well plates using the supravital stain neutral red.

C. Löwik, G. van der Pluijm, S. Papapoulos, 1993, Analytical biochemistry.

Interleukin 17 synergises with tumour necrosis factor alpha to induce cartilage destruction in vitro.

C. Löwik, S. Papapoulos, R. Van Bezooijen, 2002, Annals of the rheumatic diseases.

SOST/sclerostin, an osteocyte-derived negative regulator of bone formation.

P. ten Dijke, C. Löwik, S. Papapoulos, 2005, Cytokine & growth factor reviews.

Independent pathways in the modulation of osteoclastic resorption by intermediates of the mevalonate biosynthetic pathway: the role of the retinoic acid receptor.

M. Karperien, C. Löwik, S. Papapoulos, 2006, Bone.

Regulation of the production of plasminogen activators by bone resorption enhancing and inhibiting factors in three types of osteoblast-like cells.

J. Verheijen, C. Löwik, S. Papapoulos, 1991, Bone and mineral.

3 Nherf 2 , but not Nherf 1 overexpression , stimulates osteoblast and chondrocyte matrix mineralization

Debbie, J. Wit, M. Karperien, 2006 .

Regulation of plasminogen activation, matrix metalloproteinases and urokinase‐type plasminogen activator‐mediated extracellular matrix degradation in human osteosarcoma cell line MG63 by interleukin‐1 alpha

J. Verheijen, C. Löwik, P. Quax, 1995, Journal of bone and mineral research : the official journal of the American Society for Bone and Mineral Research.

The Role of Sclerostin in the Pathophysiology of Sclerosing Bone Dysplasias

C. Löwik, S. Papapoulos, N. Hamdy, 2012, Clinical Reviews in Bone and Mineral Metabolism.

Bone morphogenetic proteins and their antagonists: the sclerostin paradigm.

C. Löwik, S. Papapoulos, R. Van Bezooijen, 2005, Journal of endocrinological investigation.

Expression of estrogen receptor alpha and beta in the epiphyseal plate of the rat.

J. Wit, M. Karperien, B. V. D. van der Eerden, 2002, Bone.

Parathyroid hormone-related peptide (PTHrP) induces parietal endoderm formation exclusively via the Type I PTH/PTHrP receptor

B. Lanske, H. Kronenberg, L. Defize, 1999, Mechanisms of Development.

Differentiating the mechanisms of antiresorptive action of nitrogen containing bisphosphonates.

C. Löwik, S. Papapoulos, F. Ebetino, 2003, Bone.

5 Downregulation of Wnt signaling by increased expression of Dkk-1 and –2 is a pre-requisite for late stage osteoblast diﬀ erentiation of KS483 cells

C. Löwik, G. Horst, Marcel, 2005 .

Multimodality Imaging Reveals a Gradual Increase in Matrix Metalloproteinase Activity at Aneurysmal Lesions in Live Fibulin-4 Mice

P. Wielopolski, W. V. van Cappellen, J. Dijkstra, 2010, Circulation. Cardiovascular imaging.

Uncomplicated differentiation of stem cells into bipolar neurons and myelinating glia.

M. Huisman, J. Frijns, C. Löwik, 2008, Biochemical and biophysical research communications.

Differential regulation of plasminogen activation in normal keratinocytes and SCC-4 cells by fibroblasts.

P. Quax, M. Ponec, J. Verheijen, 1995, The Journal of investigative dermatology.

Multimodal imaging of hair follicle bulge-derived stem cells in a mouse model of traumatic brain injury

M. Huisman, C. Löwik, E. Suidgeest, 2020, Cell and Tissue Research.

Immunohistochemical investigations on the differentiation marker protein E11 in rat calvaria, calvaria cell culture and the osteoblastic cell line ROS 17/2.8

M. Kasper, C. Löwik, R. Funk, 1999, Histochemistry and Cell Biology.

Stimulation of bone resorption by inflamed nasal mucosa, dermonecrotic toxin-containing conditioned medium from Pasteurella multocida, and purified dermonecrotic toxin from P. multocida

T. Kimman, C. Löwik, O. Bijvoet, 1987, Infection and immunity.

Registration of Whole-Body Follow-Up MicroCT Data of Mice 6 . 1

M. Staring, B. Lelieveldt, J. Reiber, 2011 .

Celecoxib enhances doxorubicin-induced cytotoxicity in MDA-MB231 cells by NF-kappaB-mediated increase of intracellular doxorubicin accumulation.

V. V. van Hinsbergh, C. Löwik, G. van der Pluijm, 2007, European journal of cancer.

Fate of Multimeric Oligomers, Submicron, and Micron Size Aggregates of Monoclonal Antibodies Upon Subcutaneous Injection in Mice.

Jared S. Bee, W. Jiskoot, S. Bishop, 2016, Journal of pharmaceutical sciences.

A frame-shift mutation in the type I parathyroid hormone (PTH)/PTH-related peptide receptor causing Blomstrand lethal osteochondrodysplasia.

P. Nijweide, P. Nijweide, M. Karperien, 1999, The Journal of clinical endocrinology and metabolism.

Recombinant human extracellular matrix protein 1 inhibits alkaline phosphatase activity and mineralization of mouse embryonic metatarsals in vitro.

P. Feng, R. Gentz, D. Parmelee, 2001, Bone.

Nitrogen-containing bisphosphonates inhibit isopentenyl pyrophosphate isomerase/farnesyl pyrophosphate synthase activity with relative potencies corresponding to their antiresorptive potencies in vitro and in vivo.

E. Pieterman, C. Löwik, S. Papapoulos, 1999, Biochemical and biophysical research communications.

The PTTG1 is a novel inhibitor of osteogenic differentiation of mouse mesenchymal stem cells

R. Stoika, C. Löwik, O. Korchynskyi, 2016 .

The role of interleukin-6 in the induction of hypercalcemia in renal cell carcinoma transplanted into nude mice Weissglas,

K. Kurth, D. Schamhart, C. Löwik, 1997 .

Sclerostin is a delayed secreted product of osteocytes that inhibits bone formation

J. Reeve, C. Löwik, K. Poole, 2005, FASEB journal : official publication of the Federation of American Societies for Experimental Biology.

Sclerostin Is an Osteocyte-expressed Negative Regulator of Bone Formation, But Not a Classical BMP Antagonist

M. Karperien, B. Roelen, P. ten Dijke, 2004, The Journal of experimental medicine.

Expression of estrogen receptor α and β in the epiphyseal plate of the rat

J. Wit, M. Karperien, C. Löwik, 2002 .

Expression of Indian Hedgehog, Parathyroid Hormone‐Related Protein, and Their Receptors in the Postnatal Growth Plate of the Rat: Evidence for a Locally Acting Growth Restraining Feedback Loop After Birth

Marcel Karperien, J. Wit, M. Karperien, 2000, Journal of bone and mineral research : the official journal of the American Society for Bone and Mineral Research.

Increased plasma calcitonin levels in young spontaneously hypertensive rats: role in disturbed phosphate homeostasis

M. Jongen, R. Bindels, C. Löwik, 1987, Pflügers Archiv.

Osteocyte-derived sclerostin inhibits bone formation: its role in bone morphogenetic protein and Wnt signaling.

David J J de Gorter, P. ten Dijke, C. Löwik, 2008, The Journal of bone and joint surgery. American volume.

Induction of ornithine decarboxylase activity in isolated chicken osteoblasts by parathyroid hormone: The role of cAMP and calcium

C. Löwik, J. Leeuwen, M. Herrmann‐Erlee, 1988, Calcified Tissue International.

Differential expression of estrogen receptors alpha and beta mRNA during differentiation of human osteoblast SV-HFO cells.

H. Pols, J. Gustafsson, J. V. van Leeuwen, 1997, Endocrinology.

Dissociation of binding and antiresorptive properties of hydroxybisphosphonates by substitution of the hydroxyl with an amino group

C. Löwik, I. Que, S. Papapoulos, 1996, Journal of bone and mineral research : the official journal of the American Society for Bone and Mineral Research.

Binding and antiresorptive properties of heterocycle-containing bisphosphonate analogs: structure-activity relationships.

C. Löwik, F. H. Ebetino, S. Papapoulos, 1998, Bone.

The Balance Between Concurrent Activation of ERs and PPARs Determines Daidzein‐Induced Osteogenesis and Adipogenesis

C. Löwik, Z. Dang, 2004, Journal of bone and mineral research : the official journal of the American Society for Bone and Mineral Research.

Peroxisome Proliferator-activated Receptor γ (PPARγ) as a Molecular Target for the Soy Phytoestrogen Genistein*

J. Boutin, C. Löwik, V. Audinot, 2003, The Journal of Biological Chemistry.

Peroxisome proliferator-activated receptor gamma (PPARgamma ) as a molecular target for the soy phytoestrogen genistein.

J. Boutin, C. Löwik, V. Audinot, 2003, The Journal of biological chemistry.

Near-infrared labeled, ovalbumin loaded polymeric nanoparticles based on a hydrophilic polyester as model vaccine: In vivo tracking and evaluation of antigen-specific CD8(+) T cell immune response.

W. Hennink, W. Jiskoot, M. Amidi, 2015, Biomaterials.

Mesenchymal stem cells promote engraftment of human umbilical cord blood-derived CD34(+) cells in NOD/SCID mice.

J. Falkenburg, M. Heemskerk, R. Willemze, 2002, Experimental hematology.

Parathyroid hormone-related peptide as an endogenous inducer of parietal endoderm differentiation

H. Jüppner, L. Defize, A. van de Stolpe, 1993, The Journal of cell biology.

2-Methoxyestradiol Analogue ENMD-1198 Reduces Breast Cancer-Induced Osteolysis and Tumor Burden Both In Vitro and In Vivo

T. Snoeks, I. Mol, C. Löwik, 2011, Molecular Cancer Therapeutics.

Tumour progression and angiogenesis in bone metastasis from breast cancer: new approaches to an old problem.

C. Löwik, G. Pluijm, S. Papapoulos, 2000, Cancer treatment reviews.

Downregulation of Wnt Signaling by Increased Expression of Dickkopf‐1 and ‐2 is a Prerequisite for Late‐Stage Osteoblast Differentiation of KS483 Cells

M. Karperien, C. Löwik, G. van der Horst, 2005, Journal of bone and mineral research : the official journal of the American Society for Bone and Mineral Research.

Optical imaging of treatment-related tumor cell death using a heat shock protein-90 alkylator.

P. Hogg, C. Löwik, I. Que, 2013, Molecular pharmaceutics.

Optical imaging of cell death in traumatic brain injury using a heat shock protein-90 alkylator

P. Hogg, C. Löwik, E. Kaijzel, 2013, Cell Death and Disease.

Journal of Psychology and Mental Health Care

C. Löwik, 2018 .

Role of fibroblasts in the regulation of proinflammatory interleukin IL-1, IL-6 and IL-8 levels induced by keratinocyte-derived IL-1

M. Ponec, C. Ruwhof, O. Boerman, 1996, Archives of Dermatological Research.

A New Multicolor Bioluminescence Imaging Platform to Investigate NF-κB Activity and Apoptosis in Human Breast Cancer Cells

I. Mol, C. Löwik, E. Kaijzel, 2014, PloS one.

Bmc Developmental Biology

R. Fodde, J. Wit, H. Kronenberg, 2022 .

The tumor suppressor Smad4 is required for transforming growth factor beta-induced epithelial to mesenchymal transition and bone metastasis of breast cancer cells.

P. ten Dijke, C. Löwik, G. van der Pluijm, 2006, Cancer research.

Activin Receptor-like Kinase 1 Ligand Trap Reduces Microvascular Density and Improves Chemotherapy Efficiency to Various Solid Tumors

M. Goumans, J. Jonkers, P. ten Dijke, 2015, Clinical Cancer Research.

BMP-9 signals via ALK1 and inhibits bFGF-induced endothelial cell proliferation and VEGF-stimulated angiogenesis

M. V. Dinther, P. Dijke, P. ten Dijke, 2007, Journal of Cell Science.

Class III β-tubulin, a novel biomarker in the human melanocyte lineage.

M. Huisman, N. Gruis, S. M. Chuva de Sousa Lopes, 2013, Differentiation; research in biological diversity.

Monitoring Metastatic Behavior of Human Tumor Cells in Mice with Species‐Specific Polymerase Chain Reaction: Elevated Expression of Angiogenesis and Bone Resorption Stimulators by Breast Cancer in Bone Metastases

H. Vloedgraven, C. Löwik, G. van der Pluijm, 2001, Journal of bone and mineral research : the official journal of the American Society for Bone and Mineral Research.

Cytokine production by calvariae of osteopetrotic mice.

M. Cecchini, C. Löwik, W. Hofstetter, 1995, Bone.

Optical advances in skeletal imaging applied to bone metastases.

B P F Lelieveldt, T J A Snoeks, E L Kaijzel, 2011, Bone.

Advances in optical imaging and novel model systems for cancer metastasis research

R. Bachelier, P. Clézardin, C. Löwik, 2007, Clinical & Experimental Metastasis.

Modulation of IL-6 production and IL-1 activity by keratinocyte-fibroblast interaction.

M. Ponec, L. Aarden, C. Löwik, 1993, The Journal of investigative dermatology.

Apc bridges Wnt/β-catenin and BMP signaling during osteoblast differentiation of KS483 cells.

J. Wit, M. Karperien, C. Löwik, 2011, Experimental cell research.

Adenomatous polyposis coli-gene dosage controls β-catenin-mediated differentia- tion of skeletal precursors

R. Fodde, J. Wit, M. Karperien, 2011 .

Improved Multimodal Tumor Necrosis Imaging with IRDye800CW-DOTA Conjugated to an Albumin-Binding Domain

Y. Seimbille, M. de Jong, Kranthi M Panth, 2022, Cancers.

Novel Late Response Genes of PTHrP in Chondrocytes

J. Wit, M. Karperien, C. Löwik, 2006, Hormone Research in Paediatrics.

Multiple Mechanisms Are Involved in Inhibition of Osteoblast Differentiation by PTHrP and PTH in KS483 Cells

M. Karperien, C. Löwik, G. van der Horst, 2005, Journal of bone and mineral research : the official journal of the American Society for Bone and Mineral Research.

Removal of hematopoietic cells and macrophages from mouse bone marrow cultures: isolation of fibroblastlike stromal cells.

P. Nijweide, C. Löwik, T. Vrijheid-Lammers, 1994, Experimental hematology.

Effect of parathyroid hormone and parathyroid hormone fragments on the intracellular ionized calcium concentration in an osteoblast cell line.

J. V. van Leeuwen, C. Löwik, M. Bos, 1988, Bone and mineral.

Fluorescence-Guided Surgery: A Promising Approach for Future Oncologic Surgery

T. Snoeks, C. Löwik, S. Keereweer, 2014 .

Combination of Photodynamic Therapy and Specific Immunotherapy Efficiently Eradicates Established Tumors

P. B. van Driel, T. Snoeks, C. Löwik, 2015, Clinical Cancer Research.

Real-time fluorescence imaging in intraoperative decision making for cancer surgery.

E. Rosenthal, A. Vahrmeijer, G. Puppels, 2021, The Lancet. Oncology.

Preclinical uPAR-targeted multimodal imaging of locoregional oral cancer.

C. V. D. van de Velde, A. Vahrmeijer, A. Mazar, 2017, Oral oncology.

In Vivo Evaluation of Indium-111–Labeled 800CW as a Necrosis-Avid Contrast Agent

Y. Seimbille, M. de Jong, C. D. de Ridder, 2020, Molecular Imaging and Biology.

Intraoperative MET-receptor targeted fluorescent imaging and spectroscopy for lymph node detection in papillary thyroid cancer: novel diagnostic tools for more selective central lymph node compartment dissection

P. V. van Diest, R. Fehrmann, A. Gill, 2022, European Journal of Nuclear Medicine and Molecular Imaging.

Molecular imaging of tumor angiogenesis using αvβ3-integrin targeted multimodal quantum dots

Z. Fayad, M. O. oude Egbrink, K. Nicolay, 2008, Angiogenesis.

The effect of tissue type plasminogen activator (tPA) on osteoclastic resorption in embryonic mouse long bone explants: a possible role for the growth factor domain of tPA.

J. Verheijen, C. Löwik, S. Papapoulos, 1992, Bone and mineral.

Imaging bone morphogenetic protein 7 induced cell cycle arrest in experimental gliomas.

S. Vukicevic, A. Jacobs, A. Winkeler, 2011, Neoplasia.

Distinct Modes of Inhibition by Sclerostin on Bone Morphogenetic Protein and Wnt Signaling Pathways*

T. Mueller, A. Economides, David J J de Gorter, 2010, The Journal of Biological Chemistry.

Targeting nanoparticles to CD40, DEC-205 or CD11c molecules on dendritic cells for efficient CD8(+) T cell response: a comparative study.

C. Löwik, F. Ossendorp, Rodney A. Rosalia, 2014, Journal of controlled release : official journal of the Controlled Release Society.

The Tumor Suppressor Smad 4 Is Required for Transforming Growth Factor B – Induced Epithelial to Mesenchymal Transition and Bone Metastasis of Breast Cancer Cells

M. V. Dinther, P. Dijke, C. Löwik, 2006 .

Novel early target genes of parathyroid hormone-related peptide in chondrocytes.

J. Wit, M. Karperien, C. Löwik, 2006, Endocrinology.

Hedgehog stimulates only osteoblastic differentiation of undifferentiated KS483 cells.

M. Karperien, C. Löwik, G. van der Horst, 2003, Bone.

Murine malaria parasite sequestration: CD36 is the major receptor, but cerebral pathology is unlinked to sequestration.

Ivo Que, Chris J Janse, M. Mota, 2005, Proceedings of the National Academy of Sciences of the United States of America.

Wnt but Not BMP Signaling Is Involved in the Inhibitory Action of Sclerostin on BMP‐Stimulated Bone Formation

H. Vrieling, M. Karperien, P. ten Dijke, 2006, Journal of bone and mineral research : the official journal of the American Society for Bone and Mineral Research.

Different roles for calcium and cyclic AMP in the action of PTH: studies in bone explants and isolated bone cells.

P. Boonekamp, J. V. van Leeuwen, C. Löwik, 1988, Bone.

Leukemia inhibitory factor inhibits osteoclastic resorption, growth, mineralization, and alkaline phosphatase activity in fetal mouse metacarpal bones in culture

P. Nijweide, C. Löwik, S. Papapoulos, 1993, Journal of bone and mineral research : the official journal of the American Society for Bone and Mineral Research.

In vitro and Ex vivo evidence that estrogens suppress increased bone resorption induced by ovariectomy or PTH stimulation through an effect on osteoclastogenesis

C. Löwik, S. Papapoulos, L. Schot, 1995, Journal of bone and mineral research : the official journal of the American Society for Bone and Mineral Research.

pH-Channeling in Cancer: How pH-Dependence of Cation Channels Shapes Cancer Pathophysiology

A. Schwab, C. Löwik, Etmar Bulk, 2020, Cancers.

Targeted nanoparticles for the non-invasive detection of traumatic brain injury by optical imaging and fluorine magnetic resonance imaging

M. Hoehn, M. Aswendt, C. Löwik, 2016, Nano Research.

Inhibition of GSK3β Stimulates BMP Signaling and Decreases SOST Expression Which Results in Enhanced Osteoblast Differentiation

E. Valstar, R. Nelissen, C. Löwik, 2015, Journal of cellular biochemistry.

Identification of receptor-type protein tyrosine phosphatase μ as a new marker for osteocytes

J. Waarsing, C. Löwik, E. Kaijzel, 2015, Histochemistry and Cell Biology.

Lack of noggin expression by cancer cells is a determinant of the osteoblast response in bone metastases.

F. Hamdy, C. Rentsch, A. Wetterwald, 2007, The American journal of pathology.

Control of bone formation by osteocytes? lessons from the rare skeletal disorders sclerosteosis and van Buchem disease

P. Dijke, C. Löwik, Peter ten Dijke, 2005 .

Clinical Translation of Ex Vivo Sentinel Lymph Node Mapping for Colorectal Cancer Using Invisible Near-Infrared Fluorescence Light

Hak Soo Choi, John V. Frangioni, Alexander L. Vahrmeijer, 2010, Annals of Surgical Oncology.

Photodynamic-Immune Checkpoint Therapy Eradicates Local and Distant Tumors by CD8+ T Cells

C. Löwik, F. Ossendorp, M. Fransen, 2017, Cancer Immunology Research.

Optimization of near-infrared fluorescent sentinel lymph node mapping for vulvar cancer.

Cornelis J H van de Velde, Alexander L Vahrmeijer, John V Frangioni, 2012, American journal of obstetrics and gynecology.

Wnt signaling is involved in the inhibitory action of sclerostin on BMP-stimulated bone formation.

C. Löwik, R. Van Bezooijen, 2006, Journal of musculoskeletal & neuronal interactions.

immunotherapy efficiently eradicates established tumors

T. Snoeks, C. Löwik, L. Mezzanotte, 2015 .

Disodium 1‐hydroxy‐3‐(1‐pyrrolidinyl)‐propylidene‐1,1‐bisphosphonate (EB‐1053) is a potent inhibitor of bone resorption in vitro and in vivo

L. Binderup, C. Löwik, G. van der Pluijm, 1992, Journal of bone and mineral research : the official journal of the American Society for Bone and Mineral Research.

Nasal vaccination with N-trimethyl chitosan and PLGA based nanoparticles: nanoparticle characteristics determine quality and strength of the antibody response in mice against the encapsulated antigen.

Ivo Que, Joke Bouwstra, Patrick Augustijns, 2010, Vaccine.

Hypercalcemia and cosecretion of interleukin-6 and parathyroid hormone related peptide by a human renal cell carcinoma implanted into nude mice.

K. Kurth, D. Schamhart, P. Vos, 1995, The Journal of urology.

Bone morphogenetic protein 7 in the development and treatment of bone metastases from breast cancer.

S. Vukicevic, A. Cleton-Jansen, R. Lidereau, 2007, Cancer research.

BMP7, a putative regulator of epithelial homeostasis in the human prostate, is a potent inhibitor of prostate cancer bone metastasis in vivo.

Antoinette Wetterwald, Ruth Schwaninger, S. Vukicevic, 2007, The American journal of pathology.

Effects of exogenous prostanoids on the proliferation of osteoblast-like cells in vitro.

A. van der Plas, P. Nijweide, C. Löwik, 1985, Prostaglandins.

Identification of differentially expressed genes in a renal cell carcinoma tumor model after endostatin-treatment

C. Löwik, I. Que, E. V. Beek, 2004, Laboratory Investigation.

An in vitro model that can distinguish between effects on angiogenesis and on established vasculature: actions of TNP-470, marimastat and the tubulin-binding agent Ang-510.

V. V. van Hinsbergh, T. Snoeks, C. Löwik, 2010, Biochemical and biophysical research communications.

Chapter 2 Prognostic Significance of Periodic Acid-Schiff-positive Patterns in Primary Breast Cancer and its Lymph Node Metastases

V. Smit, C. Löwik, J. Buijs, 2009 .

Prognostic Significance of Periodic Acid-Schiff-Positive Patterns in Primary Breast Cancer and its Lymph Node Metastases

V. Smit, C. Löwik, G. van der Pluijm, 2004, Breast Cancer Research and Treatment.

Accelerated Atherosclerosis and Calcification in Vein Grafts: A Study in APOE*3 Leiden Transgenic Mice

P. Quax, J. H. van Bockel, V. V. van Hinsbergh, 2002, Circulation research.

A novel luciferase fusion protein for highly sensitive optical imaging: from single-cell analysis to in vivo whole-body bioluminescence imaging

C. Löwik, E. Kaijzel, L. Mezzanotte, 2014, Analytical and Bioanalytical Chemistry.

Characterization and Evaluation of the Artemis Camera for Fluorescence-Guided Cancer Surgery

A. L. Vahrmeijer, B. P. F. Lelieveldt, C. W. G. M. Löwik, 2014, Molecular Imaging and Biology.

Targeting integrins and enhanced permeability and retention (EPR) effect for optical imaging of oral cancer

A. Vahrmeijer, R. J. Baatenburg de Jong, P. B. van Driel, 2012, Journal of surgical oncology.

Bone metastasis imaging with SPECT/CT/MRI: a preclinical toolbox for therapy studies.

Steffie M. B. Peters, H. Grüll, R. Rossin, 2015, Bone.

CT-based handling and analysis of preclinical multimodality imaging data of bone metastases.

Boudewijn P F Lelieveldt, Martin Baiker, B. Lelieveldt, 2012, BoneKEy reports.

First Report on Ex vivo Delivery of Paracrine Active Human Mesenchymal Stromal Cells to Liver Grafts During Machine Perfusion.

J. Ijzermans, B. Kessler, M. Verstegen, 2020, Transplantation.

IL-1alpha, IL-1beta, IL-6, and TNF-alpha steady-state mRNA levels analyzed by reverse transcription-competitive PCR in bone marrow of gonadectomized mice.

C. Löwik, S. Papapoulos, R. Van Bezooijen, 1998, Journal of bone and mineral research : the official journal of the American Society for Bone and Mineral Research.

Near-Infrared Fluorescence Imaging of Both Colorectal Cancer and Ureters Using a Low-Dose Integrin Targeted Probe

A. Valentijn, A. Vahrmeijer, J. Vorst, 2014, Annals of Surgical Oncology.

Optical imaging of cancer metastasis to bone marrow: a mouse model of minimal residual disease.

Ivo Que, Marcel Karperien, Antoinette Wetterwald, 2002, The American journal of pathology.

Evaluating Brightness and Spectral Properties of Click Beetle and Firefly Luciferases Using Luciferin Analogues: Identification of Preferred Pairings of Luciferase and Substrate for In Vivo Bioluminescence Imaging

L. Encell, Y. Ridwan, C. Löwik, 2020, Molecular Imaging and Biology.

A Dual-Color Bioluminescence Reporter Mouse for Simultaneous in vivo Imaging of T Cell Localization and Function

C. Löwik, F. Ossendorp, L. Mezzanotte, 2019, Front. Immunol..

Early identification of non-responding locally advanced breast tumors receiving neoadjuvant chemotherapy

Jouke Dijkstra, Alexander L. Vahrmeijer, Martijn Van de Giessen, 2015, Photonics West - Biomedical Optics.

Role of trimethylated chitosan (TMC) in nasal residence time, local distribution and toxicity of an intranasal influenza vaccine.

W. Jiskoot, E. Mastrobattista, J. Heldens, 2010, Journal of controlled release : official journal of the Controlled Release Society.

Dual-Wavelength Imaging of Tumor Progression by Activatable and Targeting Near-Infrared Fluorescent Probes in a Bioluminescent Breast Cancer Model

Ivo Que, Eric L. Kaijzel, Thomas J. A. Snoeks, 2012, PloS one.

Exposure of KS483 Cells to Estrogen Enhances Osteogenesis and Inhibits Adipogenesis

M. Karperien, C. Löwik, S. Papapoulos, 2002, Journal of bone and mineral research : the official journal of the American Society for Bone and Mineral Research.

Automated Registration of Whole-Body Follow-Up MicroCT Data of Mice

Boudewijn P. F. Lelieveldt, Johan H. C. Reiber, Marius Staring, 2011, MICCAI.

Interleukin‐6 and the acute phase response during treatment of patients with paget's disease with the nitrogen‐containing bisphosphonate dimethylaminohydroxypropylidene bisphosphonate

C. Löwik, G. van der Pluijm, S. Papapoulos, 1995, Journal of bone and mineral research : the official journal of the American Society for Bone and Mineral Research.

Inducible production of nitric oxide in osteoblast-like cells and in fetal mouse bone explants is associated with suppression of osteoclastic bone resorption.

P. Nibbering, C. Löwik, S. Papapoulos, 1994, The Journal of clinical investigation.

Multicolor fluorescence imaging of traumatic brain injury in a cryolesion mouse model.

M. Hoehn, Bryan A. Smith, C. Löwik, 2012, ACS chemical neuroscience.

Bioluminescent imaging: emerging technology for non-invasive imaging of bone tissue engineering.

Clemens van Blitterswijk, Jan de Boer, C. V. van Blitterswijk, 2006, Biomaterials.

Anin situ assay system to measure ornithine decarboxylase activity in primary cultures of chicken osteoblasts: Effects of bone-seeking hormones

C. Löwik, M. Herrmann‐Erlee, J. K. Zeeland, 2007, Calcified Tissue International.

Contrast enhancement by lipid-based MRI contrast agents in mouse atherosclerotic plaques; a longitudinal study.

G. Strijkers, C. Löwik, L. van der Weerd, 2013, Contrast media & molecular imaging.

Inhibition of bone resorption and growth of breast cancer in the bone microenvironment.

C. Löwik, G. van der Pluijm, J. Buijs, 2009, Bone.

Automated Bone Volume and Thickness Measurements in Small Animal Whole-Body MicroCT Data

Boudewijn P. F. Lelieveldt, Jouke Dijkstra, Martin Baiker, 2011, Molecular Imaging and Biology.

Detecting tumour-positive resection margins after oral cancer surgery by spraying a fluorescent tracer activated by gamma-glutamyltranspeptidase.

Hisataka Kobayashi, A. Vahrmeijer, M. C. Boonstra, 2018, Oral oncology.

Optimized Longitudinal Monitoring of Stem Cell Grafts in Mouse Brain Using a Novel Bioluminescent/Near Infrared Fluorescent Fusion Reporter

C. Löwik, E. Kaijzel, L. Mezzanotte, 2017, Cell transplantation.

Effect of alendronate treatment on the osteoclastogenic potential of bone marrow cells in mice.

C. Löwik, S. Papapoulos, E. V. van Beek, 1997, Bone.

In Vivo Fluorescence Imaging of IgG1 Aggregates After Subcutaneous and Intravenous Injection in Mice

W. Jiskoot, J. Carpenter, C. Löwik, 2013, Pharmaceutical Research.

Intrinsic photosensitizer fluorescence measured using multi-diameter single-fiber spectroscopy in vivo

Arjen Amelink, H. S. de Bruijn, U. A. Gamm, 2014, Journal of biomedical optics.

Effect of PLGA NP size on efficiency to target traumatic brain injury.

T. Snoeks, C. Löwik, E. Kaijzel, 2016, Journal of controlled release : official journal of the Controlled Release Society.

EpCAM as multi-tumour target for near-infrared fluorescence guided surgery

P. Kuppen, C. V. D. van de Velde, A. Vahrmeijer, 2016, BMC Cancer.

Translational optical imaging in diagnosis and treatment of cancer.

C. V. D. van de Velde, A. Vahrmeijer, M. Hutteman, 2012, Current pharmaceutical biotechnology.

Normalized volume of interest selection and measurement of bone volume in microCT scans.

T J A Snoeks, E L Kaijzel, I Que, 2011, Bone.

Chapter 6 Bone Morphogenetic Protein 7 in the Development and Treatment of Bone Metastases from Breast Cancer

S. Vukicevic, A. Cleton-Jansen, R. Lidereau, 2009 .

Dual wavelength tumor targeting for detection of hypopharyngeal cancer using near‐infrared optical imaging in an animal model

Alexander L Vahrmeijer, Robert J Baatenburg de Jong, A. Vahrmeijer, 2012, International journal of cancer.

Differential effects of angiotensin II and transforming growth factor beta on the production of heparan sulfate proteoglycan by mesangial cells in vitro.

M. Daha, J. van den Born, L. P. Van den Heuvel, 1996, Journal of the American Society of Nephrology : JASN.

Bioluminescence imaging of bone metastasis in rodents.

T. Snoeks, C. Löwik, E. Kaijzel, 2012, Methods in molecular biology.

Design of a Variant of Vascular Endothelial Growth Factor-A (VEGF-A) Antagonizing KDR/Flk-1 and Flt-1

D. Ruiter, R. Waal, G. Breier, 2002, Laboratory Investigation.

Molecular Imaging of Inflammation in Aortic Aneurysmal Disease

J. Essers, C. Löwik, E. Kaijzel, 2012, Current Cardiovascular Imaging Reports.

Parathyroid hormone related protein and interleukin-6 mRNA expression in larynx and renal cell carcinomas from normocalcaemic and hypercalcaemic patients.

R. J. Baatenburg de Jong, C. Löwik, J. V. van Krieken, 1995, Journal of clinical pathology.

A transgenic Tie2-GFP athymic mouse model; a tool for vascular biology in xenograft tumors.

Arjan W Griffioen, M. O. oude Egbrink, A. Griffioen, 2008, Biochemical and biophysical research communications.

Multimodal imaging of hair follicle bulge-derived stem cells in a mouse model of traumatic brain injury

M. Huisman, C. Löwik, E. Suidgeest, 2020, Cell and Tissue Research.

Sensitive Dual Color In Vivo Bioluminescence Imaging Using a New Red Codon Optimized Firefly Luciferase and a Green Click Beetle Luciferase

Aldo Roda, Ivo Que, Laura Mezzanotte, 2011, PloS one.

Bioluminescence imaging on-chip platforms for non-invasive high-content bioimaging.

J. Leijten, M. Karperien, C. Löwik, 2023, Biosensors & bioelectronics.

Atlas-based whole-body segmentation of mice from low-contrast Micro-CT data

Boudewijn P. F. Lelieveldt, Julien Milles, Johan H. C. Reiber, 2010, Medical Image Anal..

Expression of vascular endothelial growth factors and their receptors during osteoblast differentiation.

M. Karperien, C. Löwik, S. Papapoulos, 2000, Endocrinology.

Optical imaging of oral squamous cell carcinoma and cervical lymph node metastasis

A. Vahrmeijer, R. J. Baatenburg de Jong, P. B. van Driel, 2012, Head & neck.

Sex steroid metabolism in the tibial growth plate of the rat.

J. Wit, M. Karperien, B. V. D. van der Eerden, 2002, Endocrinology.

Whole body optical imaging in small animals and its translation to the clinic: intra-operative optical imaging guided surgery.

P. Kuppen, C. V. D. van de Velde, A. Vahrmeijer, 2009, European Journal of Cancer.

DLP technology's pivotal role in O2view's versatile medical projection/illumination device

R. G. M. van Melick, D. Bakker, R. J. C. Meester, 2010, MOEMS-MEMS.

Image‐guided surgery in head and neck cancer: Current practice and future directions of optical imaging

H. Sterenborg, P. B. van Driel, C. Löwik, 2012, Head & neck.

Optical imaging of cancer metastasis to bone marrow: a mouse model of minimal residual disease.

M. Karperien, A. Wetterwald, M. Cecchini, 2002, The American journal of pathology.

Full Length or Fragments in Hormone Studies?

M. Karperien, C. Löwik, G. van der Horst, 2006 .

A multi-modality platform to image stem cell graft survival in the naïve and stroke-damaged mouse brain.

M. Hoehn, M. Aswendt, J. Adamczak, 2014, Biomaterials.

Integrated visualization of multi-angle bioluminescence imaging and micro CT

Charl P. Botha, Boudewijn P. F. Lelieveldt, Frits H. Post, 2007, SPIE Medical Imaging.

Articulated Planar Reformation for Change Visualization in Small Animal Imaging

Charl P. Botha, Emile A. Hendriks, Boudewijn P. F. Lelieveldt, 2010, IEEE Transactions on Visualization and Computer Graphics.

Multicolor fluorescence imaging of traumatic brain injury in a cryolesion mouse model.

M. Hoehn, C. Löwik, E. Kaijzel, 2012, ACS chemical neuroscience.

The Monoclonal Antibodies 18d7/91f2 Recognize a Receptor Regulatory Protein on Mouse Bone Marrow Stromal Cells

M. Karperien, P. van Vlasselaer, C. Löwik, 2000, Journal of bone and mineral research : the official journal of the American Society for Bone and Mineral Research.

Dual wavelength tumor targeting for detection of hypopharyngeal cancer using near‐infrared optical imaging in an animal model

A. Vahrmeijer, R. J. Baatenburg de Jong, P. B. van Driel, 2012, International journal of cancer.