D. Rodenhiser

发表

Peripheral blood epi-signature of Claes-Jensen syndrome enables sensitive and specific identification of patients and healthy carriers with pathogenic mutations in KDM5C

C. Skinner, C. Schwartz, G. Paré, 2018, Clinical Epigenetics.

Gene domain-specific DNA methylation episignatures highlight distinct molecular entities of ADNP syndrome

H. Hakonarson, R. Stevenson, C. Schwartz, 2019, Clinical Epigenetics.

DNA binding sites for putative methylation boundaries in the unmethylated region of the BRCA1 promoter

D. Butcher, T. Archer, D. Rodenhiser, 2004, International journal of cancer.

Identification of epigenetic signature associated with alpha thalassemia/mental retardation X-linked syndrome

C. Skinner, C. Schwartz, G. Paré, 2017, Epigenetics & Chromatin.

Multi-Platform Whole-Genome Microarray Analyses Refine the Epigenetic Signature of Breast Cancer Metastasis with Gene Expression and Copy Number

Ann F. Chambers, A. Chambers, D. Rodenhiser, 2010, PloS one.

Preparative labeling of proteins with [35S]methionine.

D. Rodenhiser, L. W. Browder, J. Wilkes, 1992, Analytical Biochemistry.

Heterogenous point mutations in the BRCA1 breast cancer susceptibility gene occur in high frequency at the site of homonucleotide tracts, short repeats and methylatable CpG/CpNpG motifs.

P. Ainsworth, D. Rodenhiser, J. Andrews, 1996, Oncogene.

Characterization of functional elements in the neurofibromatosis (NF1) proximal promoter region

D. Butcher, B. Sadikovic, D. Rodenhiser, 2004, Oncogene.

Epigenetic inactivation of BRCA1 is associated with aberrant expression of CTCF and DNA methyltransferase (DNMT3B) in some sporadic breast tumours.

D. Butcher, D. Rodenhiser, 2007, European journal of cancer.

Chemically induced DNA hypomethylation in breast carcinoma cells detected by the amplification of intermethylated sites

D. Butcher, B. Sadikovic, D. Rodenhiser, 2004, Breast Cancer Research.

A novel RsaI polymorphism within intron 39 of the neurofibromatosis type 1 (NF1) gene

D. Rodenhiser, K. Hovland, 1995, Human Genetics.

A genetic study of neurofibromatosis type 1 (NF1) in south-western Ontario. II. A PCR based approach to molecular and prenatal diagnosis using linkage.

J. Jung, P. Ainsworth, D. Rodenhiser, 1993, Journal of medical genetics.

A genetic study of neurofibromatosis 1 in south-western Ontario. I. Population, familial segregation of phenotype, and molecular linkage.

J. Jung, D. Rodenhiser, M. Coulter-Mackie, 1991, Journal of medical genetics.

Rapid nonradioactive detection by PCR of pHHH202/RsaI RFLP linked to neurofibromatosis type I.

P. Ainsworth, D. Rodenhiser, 1991, American journal of human genetics.

Site and sequence specific DNA methylation in the neurofibromatosis (NF1) gene includes C5839T: the site of the recurrent substitution mutation in exon 31.

D. Rodenhiser, J. Andrews, S. Singh, 1996, Human molecular genetics.

Genomic DNA Methylation-Derived Algorithm Enables Accurate Detection of Malignant Prostate Tissues

P. Ainsworth, J. Cutz, B. Sadikovic, 2018, Front. Oncol..

Clinical Validation of a Genome-Wide DNA Methylation Assay for Molecular Diagnosis of Imprinting Disorders.

C. Skinner, C. Schwartz, G. Paré, 2017, The Journal of molecular diagnostics : JMD.

Mammalian lymphocytes: stress-induced synthesis of heat-shock proteins in vitro and in vivo.

J. Jung, D. Rodenhiser, B. Atkinson, 1985, Canadian journal of biochemistry and cell biology = Revue canadienne de biochimie et biologie cellulaire.

Cancer Metastasis: Tracking and Attacking a Moving Target

A. Chambers, D. Rodenhiser, Ann F. Chambers, 2015 .

Lymphatic metastasis of breast cancer cells is associated with differential gene expression profiles that predict cancer stem cell-like properties and the ability to survive, establish and grow in a foreign environment.

A. Chambers, Guihua Zhang, D. Rodenhiser, 2009, International journal of oncology.

Constitutional Epi/Genetic Conditions: Genetic, Epigenetic, and Environmental Factors

V. Siu, P. Ainsworth, B. Sadikovic, 2016, Journal of Pediatric Genetics.

DNA methylation analysis in constitutional disorders: Clinical implications of the epigenome

G. Paré, P. Ainsworth, B. Sadikovic, 2016, Critical reviews in clinical laboratory sciences.

Site-specific DNA methylation in the neurofibromatosis (NF1) promoter interferes with binding of CREB and SP1 transcription factors

Shiva M. Singh, T. Archer, D. Rodenhiser, 1999, Oncogene.

Evidence of DNA methylation in the neurofibromatosis type 1 (NF1) gene region of 17q11.2.

D. Rodenhiser, M. Coulter-Mackie, S. Singh, 1993, Human molecular genetics.

Constitutively methylated CpG dinucleotides as mutation hot spots in the retinoblastoma gene (RB1).

P. Ainsworth, D. Rodenhiser, D. Mancini, 1997, American journal of human genetics.

Identification and characterization of sporadic and inherited mutations in exon 31 of the neurofibromatosis (NF1) gene

P. Ainsworth, D. Rodenhiser, M. Costa, 1993, Human Genetics.

Homonucleotide tracts, short repeats and CpG/CpNpG motifs are frequent sites for heterogeneous mutations in the neurofibromatosis type 1 (NF1) tumour-suppressor gene.

J. Jung, D. Rodenhiser, J. Andrews, 1997, Mutation research.

Strategies and applications of DNA level diagnosis in genetic diseases: past experiences and future directions.

J. Jung, P. Ainsworth, Shiva M. Singh, 1996, Biotechnology annual review.

Diagnostic Utility of Genome-wide DNA Methylation Testing in Genetically Unsolved Individuals with Suspected Hereditary Conditions.

I. Krantz, A. Beaudet, C. Schwartz, 2019, American journal of human genetics.

Epigenetic mapping and functional analysis in a breast cancer metastasis model using whole-genome promoter tiling microarrays

A. Chambers, B. Sadikovic, D. Rodenhiser, 2008, Breast Cancer Research.

Epigenetic contributions to cancer metastasis

D. Rodenhiser, David I. Rodenhiser, 2008, Clinical and Experimental Metastasis.

Genome-Wide Analysis in Human Colorectal Cancer Cells Reveals Ischemia-Mediated Expression of Motility Genes via DNA Hypomethylation

D. Rodenhiser, B. Coomber, J. Andrews, 2014, PloS one.

DNA methylation signatures in mendelian developmental disorders as a diagnostic bridge between genotype and phenotype.

B. Sadikovic, E. Aref-Eshghi, D. Rodenhiser, 2019, Epigenomics.

Epigenetics and human disease: translating basic biology into clinical applications

D. Rodenhiser, M. Mann, 2006, Canadian Medical Association Journal.

Functional analysis of CpG methylation in the BRCA1 promoter region

D. Butcher, T. Archer, D. Rodenhiser, 2001, Oncogene.

Gene domain-specific DNA methylation episignatures highlight distinct molecular entities of ADNP syndrome

H. Hakonarson, R. Stevenson, C. Schwartz, 2019, Clinical Epigenetics.

Clinical Validation of Fragile X Syndrome Screening by DNA Methylation Array.

C. Skinner, C. Schwartz, G. Paré, 2016, The Journal of molecular diagnostics : JMD.

Epigenetic Mediation of Environmental Exposures to Polycyclic Aromatic Hydrocarbons

B. Sadikovic, D. Rodenhiser, B. Sadikovic, 2012 .

New clinical and experimental approaches for studying tumor dormancy: does tumor dormancy offer a therapeutic target?

P. Goss, A. Chambers, P. Foster, 2008, APMIS : acta pathologica, microbiologica, et immunologica Scandinavica.

Genome-wide H3K9 Histone Acetylation Profiles Are Altered in Benzopyrene-treated MCF7 Breast Cancer Cells*

David R F Carter, B. Sadikovic, D. Rodenhiser, 2008, Journal of Biological Chemistry.

New clinical and experimental approaches for studying tumor dormancy: does tumor dormancy offer a therapeutic target?

P. Goss, A. Chambers, P. Foster, 2008 .

DNA methylation analysis using CpG microarrays is impaired in benzopyrene exposed cells.

B. Sadikovic, D. Rodenhiser, J. Andrews, 2007, Toxicology and applied pharmacology.

Benzopyrene exposure disrupts DNA methylation and growth dynamics in breast cancer cells.

B. Sadikovic, D. Rodenhiser, 2006, Toxicology and applied pharmacology.

Genomic DNA Methylation Signatures Enable Concurrent Diagnosis and Clinical Genetic Variant Classification in Neurodevelopmental Syndromes.

Hanxin Lin, Bekim Sadikovic, Kym M Boycott, 2018, American journal of human genetics.

Evaluation of DNA Methylation Episignatures for Diagnosis and Phenotype Correlations in 42 Mendelian Neurodevelopmental Disorders.

M. Shaw, N. de Leeuw, J. Gécz, 2020, American journal of human genetics.

BAFopathies’ DNA methylation epi-signatures demonstrate diagnostic utility and functional continuum of Coffin–Siris and Nicolaides–Baraitser syndromes

S. Cheung, R. Hennekam, C. Schwartz, 2018, Nature Communications.

The defining DNA methylation signature of Kabuki syndrome enables functional assessment of genetic variants of unknown clinical significance

C. Skinner, C. Schwartz, G. Paré, 2017, Epigenetics.

Allele-specific non-CpG methylation of the Nf1 gene during early mouse development.

P. Ainsworth, D. Rodenhiser, T. R. Haines, 2001, Developmental biology.

Gene signatures of breast cancer progression and metastasis

A. Chambers, T. Vandenberg, D. Rodenhiser, 2011, Breast Cancer Research.

Evaluation of DNA Methylation Episignatures for Diagnosis and Phenotype Correlations in 42 Mendelian Neurodevelopmental Disorders.

M. Shaw, N. de Leeuw, J. Gécz, 2021, American journal of human genetics.

CpG methylation within the 5′ regulatory region of the BRCA1 gene is tumor specific and includes a putative CREB binding site

F. O'Malley, P. Ainsworth, Shiva M. Singh, 1998, Oncogene.

A meeting summary of the Canadian Conference on Epigenetics

N. Bérubé, D. Rodenhiser, M. Mann, 2011 .

Ischemia dysregulates DNA methyltransferases and p16INK4a methylation in human colorectal cancer cells

D. Rodenhiser, B. Coomber, Sonam Dubey, 2010, Epigenetics.

Clinical Validation of Copy Number Variant Detection from Targeted Next-Generation Sequencing Panels.

Hanxin Lin, Bekim Sadikovic, Robert A Hegele, 2017, The Journal of molecular diagnostics : JMD.

Molecular cytogenetic characterization of human breast cancer cell line MDA-MB-468 and its variant 468LN, which displays aggressive lymphatic metastasis.

A. Chambers, D. Rodenhiser, A. Tuck, 2008, Cancer genetics and cytogenetics.

Sodium bisulfite analysis of the methylation status of DNA from small portions of paraffin slides.

D. Butcher, B. Sadikovic, D. Rodenhiser, 2001, BioTechniques.

Basic principles of epigenetics: DNA methylation and histone modifications

D. Rodenhiser, 2006 .

Human 21T breast epithelial cell lines mimic breast cancer progression in vivo and in vitro and show stage-specific gene expression patterns

A. Chambers, Guihua Zhang, H. Leong, 2010, Laboratory Investigation.

Distinct karyotypes in three breast cancer cell lines --21PTCi, 21NTCi, and 21MT-1 --derived from the same patient and representing different stages of tumor progression.

A. Chambers, D. Rodenhiser, A. Tuck, 2008, Cancer genetics and cytogenetics.

Abstracts from the 53rd European Society of Human Genetics (ESHG) Conference: Oral Presentations

K., Lin, H., 2020, European Journal of Human Genetics.

Characterization of an intron 31 splice junction mutation in the neurofibromatosis type 1 (NF1) gene.

P. Ainsworth, D. Rodenhiser, A. Stuart, 1994, Human molecular genetics.

Gene signatures of breast cancer progression and metastasis

A. Chambers, T. Vandenberg, D. Rodenhiser, 2011, Breast Cancer Research.

Scholarship@Western Scholarship@Western

N. Bérubé, D. Rodenhiser, Mellissa R.W. Mann, 2022 .

Genomic DNA Methylation Signatures Enable Concurrent Diagnosis and Clinical Genetic Variant Classification in Neurodevelopmental Syndromes.

C. Skinner, C. Schwartz, G. Paré, 2018, American journal of human genetics.

The synergistic effect of hyperthermia and ethanol on changing gene expression of mouse lymphocytes.

D. Rodenhiser, B. Atkinson, J. Jung, 1986, Canadian journal of genetics and cytology. Journal canadien de genetique et de cytologie.