A. Marx

发表

Role of ubiquitin and the HPV E6 oncoprotein in E6AP-mediated ubiquitination

M. Scheffner, S. Kühnle, F. Mortensen, 2015, Proceedings of the National Academy of Sciences.

Real-Time Cellular Imaging of Protein Poly(ADP-ribos)ylation.

A. Zumbusch, E. Ferrando-May, A. Marx, 2016, Angewandte Chemie.

Opposed Steric Constraints in Human DNA Polymerase and E . coli DNA

Dina Grohmann, A. Marx, T. Restle, 2009 .

Reverse-transcription quantitative PCR directly from cells without RNA extraction and without isothermal reverse-transcription: a ‘zero-step’ RT-qPCR protocol

M. Leist, A. Marx, Petra Chovancová, 2017, Biology methods & protocols.

Efficient labelling of enzymatically synthesized vinyl-modified DNA by an inverse-electron-demand Diels-Alder reaction.

A. Marx, R. Winter, V. Wittmann, 2014, Chemical communications.

DNA polymerases and biotechnological applications.

A. Marx, Joos Aschenbrenner, 2017, Current opinion in biotechnology.

Engineered DNA Polymerases in Biotechnology

A. Marx, Ramon Kranaster , 2010, Chembiochem : a European journal of chemical biology.

Evolving a thermostable DNA polymerase that amplifies from highly damaged templates.

C. Gloeckner, A. Marx, Katharina B M Sauter, 2007, Angewandte Chemie.

Quantitative analysis of the binding affinity of poly(ADP-ribose) to specific binding proteins as a function of chain length

M. Altmeyer, A. Bürkle, A. Marx, 2007, Nucleic acids research.

Combining the Sensitivity of LAMP and Simplicity of Primer Extension via a DNA-Modified Nucleotide

A. Marx, M. Welter, 2020, Chemistry.

Click chemistry for targeted protein ubiquitylation and ubiquitin chain formation

M. Scheffner, Daniel Schneider, A. Marx, 2015, Nature Protocols.

Bioorthogonally Functionalized NAD(+) Analogues for In-Cell Visualization of Poly(ADP-Ribose) Formation.

A. Zumbusch, Yan Wang, A. Marx, 2016, Angewandte Chemie.

Evolving thermostable reverse transcriptase activity in a DNA polymerase scaffold.

A. Marx, Katharina B M Sauter, 2006, Angewandte Chemie.

Proline-modified DNA as catalyst of the aldol reaction.

A. Marx, Zhuo Tang, 2007, Angewandte Chemie.

A nucleoside triphosphate for site-specific labelling of DNA by the Staudinger ligation.

A. Marx, S. Weisbrod, 2007, Chemical communications.

Novel DNA Catalysts Based on G‐Quadruplex Recognition

Markus Wieland, J. S. Hartig, A. Marx, 2008, Chembiochem : a European journal of chemical biology.

A class of mild surfactants that keep integral membrane proteins water-soluble for functional studies and crystallization

C. Tate, J. Popot, W. Welte, 2011, Molecular membrane biology.

Exploring the Effects of Active Site Constraints on HIV-1 Reverse Transcriptase DNA Polymerase Fidelity*

A. Marx, T. Restle, Michael Strerath, 2002, The Journal of Biological Chemistry.

Prolonged intrathecal release of soluble Fas following severe traumatic brain injury in humans

M. Morganti-Kossmann, T. Kossmann, O. Trentz, 2002, Journal of Neuroimmunology.

Tuning PCR specificity by chemically modified primer probes.

A. Marx, M. Strerath, 2002, Angewandte Chemie.

Identification of Bioactive Small Molecule Inhibitors of Separase.

O. Stemmann, A. Marx, T. Mayer, 2019, ACS chemical biology.

Inhibition of protein synthesis by the T cell receptor-inducible human TDAG51 gene product.

O. Janssen, D. Kabelitz, A. Marx, 2001, Cellular signalling.

Directed Evolution of DNA Polymerases: Construction and Screening of DNA Polymerase Mutant Libraries

C. Gloeckner, A. Marx, R. Kranaster, 2010, Current protocols in chemical biology.

Modified oligonucleotides as tools for allele-specific amplification.

A. Marx, M. Strerath, I. Detmer, 2007, Methods in molecular biology.

Recognition of Remote Mismatches by DNA Polymerases

A. Marx, M. Strerath, J. Gaster, 2004, Chembiochem : a European journal of chemical biology.

Crystal structures of ternary complexes of archaeal B-family DNA polymerases

K. Diederichs, A. Marx, H. Kropp, 2017, PloS one.

Chemical Proteomics of the Tumor Suppressor Fhit Covalently Bound to the Cofactor Ap3A Elucidates Its Inhibitory Action on Translation

K. Diederichs, Florian Stengel, A. Marx, 2022, Journal of the American Chemical Society.

Generation of a Mono‐ubiquitinated PCNA Mimic by Click Chemistry

M. Scheffner, U. Hübscher, M. Rubini, 2011, Chembiochem : a European journal of chemical biology.

A modified uridine for the synthesis of branched DNA

S. Keller, A. Marx, Yan Luo, 2007 .

Anionic surfactants enhance click reaction-mediated protein conjugation with ubiquitin.

M. Scheffner, F. Mortensen, Daniel Schneider, 2016, Bioorganic & medicinal chemistry.

Microenvironment-Sensitive Fluorescent Nucleotide Probes from Benzofuran, Benzothiophene, and Selenophene as Substrates for DNA Polymerases.

K. Diederichs, P. Ghosh, A. Marx, 2022, Journal of the American Chemical Society.

The use of enzymes for construction of DNA-based objects and assemblies.

Sascha Keller, Andreas Marx, S. Keller, 2011, Chemical Society reviews.

The Use of Enzymes for Construction of DNA‐Based Objects and Assemblies

S. Keller, A. Marx, 2012 .

DNA polymerase-catalyzed DNA network growth.

S. Keller, R. Berger, A. Marx, 2008, Journal of the American Chemical Society.

The influence of structural gradients in large pore organosilica materials on the capabilities for hosting cellular communities

M. Leist, S. Polarz, A. Marx, 2020, RSC advances.

Assembly of branched ubiquitin oligomers by click chemistry.

M. Scheffner, A. Marx, Xiaohui Zhao, 2019, Chemical communications.

A New Photoactive Building Block for Investigation of DNA Backbone Interactions: Photoaffinity Labeling of Human DNA Polymerase β

A. Marx, Francesca Di Pasquale, Meike Liebmann, 2006, Chembiochem : a European journal of chemical biology.

Chain-terminating and clickable NAD⁺ analogues for labeling the target proteins of ADP-ribosyltransferases.

Yan Wang, A. Marx, Magdalena Grzywa, 2014, Angewandte Chemie.

Inhibitors of the Diadenosine Tetraphosphate Phosphorylase Rv2613c of Mycobacterium tuberculosis.

J. Dürig, A. Marx, S. Stenger, 2017, ACS chemical biology.

Small‐Molecule Inhibitors of the Tumor Suppressor Fhit

M. Scheffner, A. Marx, S. Hacker, 2017, Chembiochem : a European journal of chemical biology.

Profiling of the ADP‐Ribosylome in Living Cells

Florian Stengel, A. Marx, Sonja Rieth, 2022, Angewandte Chemie.

Combining molecular dynamics simulations and scoring method to computationally model ubiquitylated linker histones in chromatosomes

A. Marx, Kevin Sawade, O. Kukharenko, 2022, bioRxiv.

Electrostatic and steric effects underlie acetylation-induced changes in ubiquitin structure and function

M. Scheffner, Christoph Globisch, Florian Stengel, 2022, Nature Communications.

Enzymatic synthesis of multiple spin-labeled DNA.

G. Jeschke, A. Marx, M. Yulikov, 2008, Angewandte Chemie.

Structure and function of an RNA-reading thermostable DNA polymerase.

K. Diederichs, Markus Wieland, W. Welte, 2013, Angewandte Chemie.

Enzymatic synthesis of 8-vinyl- and 8-styryl-2'-deoxyguanosine modified DNA--novel fluorescent molecular probes.

U. Diederichsen, A. Marx, Vanessa Siegmund, 2012, Bioorganic & medicinal chemistry letters.

Synthesis of disaccharide nucleoside analogues as potential poly(ADP-ribose) polymerase-1 inhibitors.

A. Marx, K. Götz, Martin Mex, 2018, Organic & biomolecular chemistry.

New Light‐Sensitive Nucleosides for Caged DNA Strand Breaks

T. Bickle, B. Giese, A. Marx, 2002, Chembiochem : a European journal of chemical biology.

Site-specific DNA labeling by Staudinger ligation.

A. Marx, S. Weisbrod, Anna Baccaro, 2011, Methods in molecular biology.

Diamondoid-modified DNA.

P. Schreiner, Yan Wang, A. Marx, 2011, Organic & biomolecular chemistry.

DNA-templated synthesis: more versatile than expected.

A. Marx, D. Summerer, 2002, Angewandte Chemie.

A human RNA ligase that operates via auto- and RNA-AMPylation

K. Diederichs, M. Scheffner, Florian Stengel, 2022, bioRxiv.

Exploring the protein stabilizing capability of surfactants against agitation stress and the underlying mechanisms.

J. Carpenter, A. Marx, G. Fricker, 2022, Journal of pharmaceutical sciences.

Structure-function relationship of thiazolide-induced apoptosis in colorectal tumor cells.

T. Brunner, A. Marx, K. Stemmer, 2014, ACS chemical biology.

An efficient method for the construction of functionalized DNA bearing amino acid groups through cross-coupling reactions of nucleoside triphosphates followed by primer extension or PCR.

P. Čapek, R. Pohl, Michal Hocek, 2007, Chemistry.

Live Cell Imaging of Enzymatic Turnover of an Adenosine 5′-Tetraphosphate Analog

A. Zumbusch, M. Winterhalder, A. Marx, 2021, International journal of molecular sciences.

Specific incorporation of an artificial nucleotide opposite a mutagenic DNA adduct by a DNA polymerase.

Fritz Eichenseher, A. Marx, S. Sturla, 2015, Journal of the American Chemical Society.

Thiamine pyrophosphate stimulates acetone activation by Desulfococcus biacutus as monitored by a fluorogenic ATP analogue.

B. Schink, A. Marx, N. Hardt, 2014, ACS chemical biology.

Barcoded nucleotides.

A. Marx, Anna Baccaro, A. Steck, 2012, Angewandte Chemie.

Varied Active‐Site Constraints in the Klenow Fragment of E. coli DNA Polymerase I and the Lesion‐Bypass Dbh DNA Polymerase

A. Marx, T. Restle, Gopinath Rangam, 2008, Chembiochem : a European journal of chemical biology.

Varied DNA Polymerase—Substrate Interactions in the Nucleotide Binding Pocket

A. Marx, D. Summerer, M. Strerath, 2002, Chembiochem : a European journal of chemical biology.

Differential minor groove interactions between DNA polymerase and sugar backbone of primer and template strands.

A. Marx, D. Summerer, 2002, Journal of the American Chemical Society.

Structural Basis for Expansion of the Genetic Alphabet with an Artificial Nucleobase Pair.

K. Diederichs, A. Marx, I. Hirao, 2017, Angewandte Chemie.

Enzymatic synthesis of perfluoroalkylated DNA.

A. Marx, Bastian Holzberger, 2009, Bioorganic & medicinal chemistry.

Structural insights into DNA replication without hydrogen bonds.

K. Diederichs, T. Lavergne, W. Welte, 2013, Journal of the American Chemical Society.

Increased single nucleotide discrimination in arrayed primer elongation by 4'C-modified primer probes.

A. Marx, Gopinath Rangam, J. Gaster, 2007, Chemical communications.

Variants of sequence family B Thermococcus kodakaraensis DNA polymerase with increased mismatch extension selectivity

A. Marx, C. Huber, 2017, PloS one.

Expanding the scope of human DNA polymerase λ and β inhibitors.

T. Brunner, A. Marx, A. Hantusch, 2014, ACS chemical biology.

Small‐molecule Inhibitors of Dna Polymerase Function Weitere Publikationen: 4.4.2) Side‐by‐side Comparison of Sm1 and Sm49 with Reported Inhibitors ...................38 5) Synthesis of 4'‐c‐alkylated‐5‐iodo‐2'‐deoxypyrimidine Nucleosides as Potential Antiviral Drugs and Synthetic Building Blocks ..

G. Müller, T. Brunner, B. Schink, 2022 .

Synthesis and biological evaluation of optimized inhibitors of the mitotic kinesin Kif18A.

A. Marx, T. Mayer, J. Braun, 2015, ACS chemical biology.

DNA minor groove hydration probed with 4'-alkylated thymidines.

A. Marx, D. Summerer, I. Detmer, 2002, Chemical communications.

BTB-1: a small molecule inhibitor of the mitotic motor protein Kif18A.

Andreas Marx, A. Marx, T. Mayer, 2009, Angewandte Chemie.

Selective monitoring of the enzymatic activity of the tumor suppressor Fhit.

M. Scheffner, A. Marx, S. Hacker, 2014, Angewandte Chemie.

Fluorescence-Lifetime-Sensitive Probes for Monitoring ATP Cleavage.

A. Zumbusch, A. Marx, Daniel Hammler, 2018, Chemistry.

Synthesis and fluorescence characteristics of ATP-based FRET probes.

A. Marx, N. Hardt, S. M. Hacker, 2013, Organic & biomolecular chemistry.

Fluorogenic ATP analogues for online monitoring of ATP consumption: observing ubiquitin activation in real time.

M. Scheffner, Daniel Schneider, A. Marx, 2013, Angewandte Chemie.

Fingerprinting differential active site constraints of ATPases

M. Scheffner, C. Hauck, Alexander Buntru, 2013 .

An adamantane-based building block for DNA networks.

A. Marx, Richa Pathak, 2011, Chemistry, an Asian journal.

Novel strategies for the site-specific covalent labelling of nucleic acids.

A. Marx, S. Weisbrod, 2008, Chemical communications.

Molecular Insights into Error‐Prone DNA Replication and Error‐Free Lesion Bypass

A. Marx, D. Summerer, 2002, Chembiochem : a European journal of chemical biology.

Structural basis for the selective incorporation of an artificial nucleotide opposite a DNA adduct by a DNA polymerase.

K. Diederichs, A. Marx, S. Sturla, 2017, Chemical communications.

Antibody–nucleotide conjugate as a substrate for DNA polymerases† †Electronic supplementary information (ESI) available. See DOI: 10.1039/c8sc01839a

J. Bálintová, A. Marx, J Balintová, 2018, Chemical science.

Phosphate-Modified Nucleotides for Monitoring Enzyme Activity

A. Marx, S. M. Hacker, Susanne Ermert, 2017, Topics in Current Chemistry.

Fluorescently Labelled ATP Analogues for Direct Monitoring of Ubiquitin Activation

M. Scheffner, Fabian Offensperger, A. Zumbusch, 2020, Chemistry.

4'C-modified nucleotides as chemical tools for investigation and modulation of DNA polymerase function

A. Marx, D. Summerer, 2004 .

Implications of active site constraints on varied DNA polymerase selectivity.

A. Marx, T. Restle, J. Cramer, 2002, Journal of the American Chemical Society.

The synthesis of 2′-methylseleno adenosine and guanosine 5′-triphosphates

R. Micura, A. Marx, T. Santner, 2012, Bioorganic & medicinal chemistry.

Structural Basis for the KlenTaq DNA Polymerase Catalysed Incorporation of Alkene- versus Alkyne-Modified Nucleotides.

K. Diederichs, A. Marx, A. Hottin, 2017, Chemistry.

Structures of KlenTaq DNA polymerase caught while incorporating C5-modified pyrimidine and C7-modified 7-deazapurine nucleoside triphosphates.

K. Diederichs, W. Welte, A. Marx, 2012, Journal of the American Chemical Society.

Structures of KOD and 9°N DNA Polymerases Complexed with Primer Template Duplex

K. Diederichs, W. Welte, A. Marx, 2013, Chembiochem : a European journal of chemical biology.

Enzymatic synthesis of organic-polymer-grafted DNA.

A. Marx, Anna Baccaro, 2010, Chemistry.

Nucleotide analogues as probes for DNA polymerases

A. Marx, K. Jung, 2005, Cellular and Molecular Life Sciences CMLS.

A molecular beacon for quantitative monitoring of the DNA polymerase reaction in real-time.

A. Marx, D. Summerer, 2002, Angewandte Chemie.

4‘-Acylated Thymidines: A New Class of DNA Chain Terminators and Photocleavable DNA Building Blocks

T. Bickle, B. Giese, A. Marx, 1997 .

Variants of a Thermus aquaticus DNA Polymerase with Increased Selectivity for Applications in Allele- and Methylation-Specific Amplification

R. Blasczyk, A. Marx, R. Kranaster, 2014, PloS one.

Structures of DNA polymerases caught processing size-augmented nucleotide probes.

K. Diederichs, T. Exner, W. Welte, 2010, Angewandte Chemie.

Chemical Biology of DNA Replication : probing DNA Polymerase selectivity mechanisms with modified Nucleotides

A. Marx, 2010 .

Steric Constraints Dependent on Nucleobase Pair Orientation Vary in Different DNA Polymerase Active Sites

H. Möller, A. Marx, Gopinath Rangam, 2009, Chembiochem : a European journal of chemical biology.

Increased Single‐Nucleotide Discrimination of PCR by Primer Probes Bearing Hydrophobic 4′C Modifications

A. Marx, D. Summerer, M. Strerath, 2004, Chembiochem : a European journal of chemical biology.

Synthesis of 4′-C-alkylated-5-iodo-2′-deoxypyrimidine nucleosides

A. Marx, N. Hardt, T. Strittmatter, 2013 .

6‐Substituted 2‐Aminopurine‐2′‐deoxyribonucleoside 5′‐Triphosphates that Trace Cytosine Methylation

A. Marx, Janina von Watzdorf, 2016, Chembiochem : a European journal of chemical biology.

Hydrophobic amino acid and single-atom substitutions increase DNA polymerase selectivity.

A. Marx, R. Kranaster, Nicolas Z. Rudinger, 2007, Chemistry & biology.

Synthesis of C8‐Arylamine‐Modified 2′‐Deoxyadenosine Phosphoramidites and their Site‐Specific Incorporation into Oligonucleotides

A. Marx, C. Meier, Z. Szombati, 2012, Chembiochem : a European journal of chemical biology.

Synthesis of DNA strands site-specifically damaged by c8-arylamine purine adducts and effects on various DNA polymerases.

A. Marx, C. Meier, Francesca Di Pasquale, 2008, Chemistry.

Enzymatic synthesis of 2′-methylseleno-modified RNA

R. Micura, A. Marx, T. Santner, 2011 .

Sequence-Specific Incorporation of Enzyme-Nucleotide Chimera by DNA Polymerases.

A. Marx, M. Welter, D. Verga, 2016, Angewandte Chemie.

Structural Insights into the Processing of Nucleobase-Modified Nucleotides by DNA Polymerases.

A. Marx, A. Hottin, 2016, Accounts of chemical research.

DNA polymerase-catalyzed incorporation of nucleotides modified with a G-quadruplex-derived DNAzyme.

A. Marx, M. Welter, D. Verga, 2015, Chemical communications.

Structural basis for the synthesis of nucleobase modified DNA by Thermus aquaticus DNA polymerase

K. Diederichs, W. Welte, A. Marx, 2010, Proceedings of the National Academy of Sciences.

A DNA Polymerase with Increased Reactivity for Ribonucleotides and C5‐Modified Deoxyribonucleotides

A. Marx, Nadine Staiger, 2010, Chembiochem : a European journal of chemical biology.

Direct Sensing of 5-Methylcytosine by Polymerase Chain Reaction

Markus Wieland, A. Marx, Joos Aschenbrenner, 2014, Angewandte Chemie.

Identification of Thermus aquaticus DNA polymerase variants with increased mismatch discrimination and reverse transcriptase activity from a smart enzyme mutant library

A. Marx, Govindan Raghunathan, 2019, Scientific Reports.

Directed DNA Polymerase Evolution: Effects of Mutations in Motif C on the Mismatch‐Extension Selectivity of Thermus aquaticus DNA Polymerase

C. Gloeckner, Andrea Schnur, A. Marx, 2007, Chembiochem : a European journal of chemical biology.

RNA pathogen detection with one-step reverse transcription PCR and strand-displacement based signal amplification.

A. Marx, Zhuo Tang, Frank Streckenbach, 2013, The Analyst.

One‐step RNA pathogen detection with reverse transcriptase activity of a mutated thermostable Thermus aquaticus DNA polymerase

F. Hufert, M. Weidmann, A. Marx, 2010, Biotechnology journal.

Genotyping--from genomic DNA to genotype in a single tube.

A. Marx, M. Strerath, 2005, Angewandte Chemie.

A new building block for DNA network formation by self-assembly and polymerase chain reaction

S. Keller, M. Drescher, M. Robotta, 2014, Beilstein journal of organic chemistry.

5-methylcytosine-sensitive variants of Thermococcus kodakaraensis DNA polymerase

A. Marx, C. Huber, Janina von Watzdorf, 2016, Nucleic acids research.

Modified Nucleotides for Discrimination between Cytosine and the Epigenetic Marker 5‐Methylcytosine

A. Marx, K. Leitner, Janina von Watzdorf, 2016, Angewandte Chemie.

Detektion von 5‐Methylcytosin in unbehandelter genomischer DNA durch Polymerasekettenreaktion

Markus Wieland, A. Marx, Joos Aschenbrenner, 2014 .

Direct and site-specific quantification of RNA 2′-O-methylation by PCR with an engineered DNA polymerase

Andreas Marx, A. Marx, Joos Aschenbrenner, 2016, Nucleic acids research.

Formation of the Alarmones Diadenosine Triphosphate and Tetraphosphate by Ubiquitin- and Ubiquitin-like-Activating Enzymes.

M. Scheffner, Fabian Offensperger, A. Marx, 2019, Cell chemical biology.

Direct measurement of electrical transport through G-quadruplex DNA with mechanically controllable break junction electrodes.

E. Scheer, A. Marx, A. Erbe, 2010, Angewandte Chemie.

A highly active DNA polymerase with a fluorous core.

M. Rubini, H. Möller, A. Marx, 2010, Angewandte Chemie.

Taking fingerprints of DNA polymerases: multiplex enzyme profiling on DNA arrays.

A. Marx, R. Kranaster, 2009, Angewandte Chemie.

Chemical proteomics reveals interactors of the alarmone diadenosine triphosphate in the cancer cell line H1299 †

Florian Stengel, A. Marx, M. L. Niedermeier, 2022, Journal of peptide science : an official publication of the European Peptide Society.

Chemical proteomic profiling reveals protein interactors of the alarmones diadenosine triphosphate and tetraphosphate

M. Scheffner, Florian Stengel, A. Marx, 2021, Nature Communications.

Chemical Trapping of the Dynamic MutS-MutL Complex Formed in DNA Mismatch Repair in Escherichia coli*

Peter Friedhoff, Ute Curth, Titia K. Sixma, 2011, The Journal of Biological Chemistry.

MutS/MutL crystal structure reveals that the MutS sliding clamp loads MutL onto DNA

J. Lebbink, H. Winterwerp, T. Sixma, 2015, eLife.

Different Enzymatic Processing of γ‐Phosphoramidate and γ‐Phosphoester‐Modified ATP Analogues

M. Scheffner, C. Hauck, Alexander Buntru, 2017, Chembiochem : a European journal of chemical biology.

Application of the C4'-Alkylated Deoxyribose Primer System (CAPS) in Allele-Specific Real-Time PCR for Increased Selectivity in Discrimination of Single Nucleotide Sequence Variants

A. Pingoud, P. Friedhoff, A. Marx, 2003, Biological chemistry.

Improved LNA probe-based assay for the detection of African and South American yellow fever virus strains.

O. Faye, F. Hufert, M. Weidmann, 2010, Journal of clinical virology : the official publication of the Pan American Society for Clinical Virology.

Preferential Extracellular Generation of the Active Parkinsonian Toxin MPP+ by Transporter-Independent Export of the Intermediate MPDP+

Karsten Hiller, Marcel Leist, Andreas Marx, 2015, Antioxidants & redox signaling.

KlenTaq DNA Polymerase Adopts Unique Recognition States when Encountering Matched, Mismatched, and Abasic Template Sites: An NMR Study

M. Pszolla, H. Möller, A. Marx, 2012, Chembiochem : a European journal of chemical biology.

Amino Acid Templating Mechanisms in Selection of Nucleotides Opposite Abasic Sites by a Family A DNA Polymerase*

K. Diederichs, W. Welte, A. Marx, 2012, The Journal of Biological Chemistry.

Learning from Directed Evolution: Thermus aquaticus DNA Polymerase Mutants with Translesion Synthesis Activity

Kay Diederichs, Andreas Marx, K. Diederichs, 2011, Chembiochem : a European journal of chemical biology.

Replication through an abasic DNA lesion: structural basis for adenine selectivity

K. Diederichs, W. Welte, Andrea Schnur, 2010, The EMBO journal.

Modulating the pKa of a Tyrosine in KlenTaq DNA Polymerase that Is Crucial for Abasic Site Bypass by in Vivo Incorporation of a Non‐canonical Amino Acid

A. Deiters, A. Marx, Alexander Prokup, 2014, Chembiochem : a European journal of chemical biology.

Functionalized DNA Hydrogels Produced by Polymerase‐Catalyzed Incorporation of Non‐Natural Nucleotides as a Surface Coating for Cell Culture Applications

C. Niemeyer, M. Leist, A. Marx, 2019, Advanced healthcare materials.

Designer Extracellular Matrix Based on DNA-Peptide Networks Generated by Polymerase Chain Reaction.

A. Marx, M. Manea, Alexander Finke, 2016, Angewandte Chemie.

Interactome of Site-Specifically Acetylated Linker Histone H1.

M. Scheffner, Florian Stengel, A. Marx, 2021, Journal of proteome research.

The interactome of site-specifically acetylated linker histone H1

M. Scheffner, Florian Stengel, A. Marx, 2021, bioRxiv.

The Structure of an Archaeal B-Family DNA Polymerase in Complex with a Chemically Modified Nucleotide.

K. Diederichs, A. Marx, H. Kropp, 2019, Angewandte Chemie.

Snapshots of a modified nucleotide moving through the confines of a DNA polymerase

K. Diederichs, A. Marx, H. Kropp, 2018, Proceedings of the National Academy of Sciences.

PARP1 catalytic variants reveal branching and chain length-specific functions of poly(ADP-ribose) in cellular physiology and stress response

A. Hartwig, A. Bürkle, E. Ferrando-May, 2020, Nucleic acids research.

Engineering of a DNA Polymerase for Direct m6A Sequencing

Andreas Marx, Yuri Motorin, Mark Helm, 2017, Angewandte Chemie.

The use of an artificial nucleotide for polymerase-based recognition of carcinogenic O6-alkylguanine DNA adducts

A. Marx, S. Sturla, L. A. Wyss, 2016, Nucleic acids research.

Site-specific ubiquitylation acts as a regulator of linker histone H1

M. Scheffner, Florian Stengel, Kai-Michael Kammer, 2021, Nature Communications.

Lesion Bypass Activity of DNA Polymerase A from the Extremely Radioresistant Organism Deinococcus radiodurans*

Kathrin Heinz, A. Marx, 2007, Journal of Biological Chemistry.

Small Molecule Inhibitors of Human DNA Polymerase λ.

A. Marx, T. Mayer, T. Huhn, 2011, ACS chemical biology.

Human DNA Polymerase β Mutations Allowing Efficient Abasic Site Bypass*

K. Diederichs, W. Welte, A. Marx, 2010, The Journal of Biological Chemistry.

Direct Monitoring of Nucleotide Turnover in Human Cell Extracts and Cells by Fluorogenic ATP Analogs.

A. Zumbusch, A. Marx, Annette Buntz, 2015, ACS chemical biology.

Structural and functional consequences of NEDD8 phosphorylation

M. Scheffner, A. Marx, M. Kovermann, 2021, Nature Communications.

Improving bioorthogonal protein ubiquitylation by click reaction.

M. Scheffner, Daniel Schneider, A. Marx, 2013, Bioorganic & medicinal chemistry.

Identification of Small-Molecule Activators of the Ubiquitin Ligase E6AP/UBE3A and Angelman Syndrome-Derived E6AP/UBE3A Variants.

M. Scheffner, Florian Stengel, Fabian Offensperger, 2020, Cell chemical biology.

Identification of Proteins Interacting with Ubiquitin Chains.

M. Scheffner, Florian Stengel, A. Marx, 2017, Angewandte Chemie.

Dissecting ubiquitin signaling with linkage-defined and protease resistant ubiquitin chains.

M. Scheffner, Daniel Schneider, A. Marx, 2014, Angewandte Chemie.

Synthesis of defined ubiquitin dimers.

M. Scheffner, M. Rubini, A. Marx, 2010, Journal of the American Chemical Society.

The Length of a Ubiquitin Chain: A General Factor for Selective Recognition by Ubiquitin‐Binding Proteins

M. Scheffner, Florian Stengel, A. Marx, 2020, Angewandte Chemie.

Chemistry and Biochemistry of DNA Radicals

B. Giese, A. Marx, U. Schwitter, 1997 .

Thiazolides promote apoptosis in colorectal tumor cells via MAP kinase-induced Bim and Puma activation

E. Coccia, D. Lenze, M. Tschan, 2015, Cell Death and Disease.

Molecular Beacons: Signalling Nucleic Acid Probes, Methods, and Protocols

O. Seitz, A. Marx, 2008, Methods in Molecular Biology.

Investigation of the action of poly(ADP-ribose)-synthesising enzymes on NAD+ analogues

A. Marx, E. Simpson, Sarah Wallrodt, 2017, Beilstein journal of organic chemistry.

Thiolated nucleotides for immobilisation of DNA oligomers on gold surfaces.

E. Scheer, A. Marx, A. Erbe, 2008, Chemphyschem : a European journal of chemical physics and physical chemistry.

Single-molecule multiparameter fluorescence spectroscopy reveals directional MutS binding to mismatched bases in DNA

Caroline P. Jung, C. Seidel, E. Sisamakis, 2012, Nucleic acids research.

Interactions of non-polar and "Click-able" nucleotides in the confines of a DNA polymerase active site.

K. Diederichs, A. Marx, H. Busskamp, 2012, Chemical communications.

Structural insights into the potential of 4-fluoroproline to modulate biophysical properties of proteins

K. Diederichs, W. Welte, A. Marx, 2012 .

Replacing 32 proline residues by a noncanonical amino acid results in a highly active DNA polymerase.

A. Marx, Bastian Holzberger, 2010, Journal of the American Chemical Society.

Ubiquitin Designer Proteins as a New Additive Generation towards Controlling Crystallization.

A. Marx, C. Ruiz-Agudo, D. Gebauer, 2019, Journal of the American Chemical Society.

Inhibitor-Directed Spin Labelling-A High Precision and Minimally Invasive Technique to Study the Conformation of Proteins in Solution.

A. Schmitz, A. Marx, G. Hagelueken, 2018, Chemistry.

GFAP‐independent inflammatory competence and trophic functions of astrocytes generated from murine embryonic stem cells

Marcel Leist, Sascha Keller, Andreas Marx, 2012, Glia.

Sequence selective naked-eye detection of DNA harnessing extension of oligonucleotide-modified nucleotides.

A. Marx, M. Welter, D. Verga, 2016, Bioorganic & medicinal chemistry letters.

Electrochemical Detection of Oxacillin Resistance using Direct-Labeling Solid-Phase Isothermal Amplification.

A. Marx, D. Corrigan, Adrian Butterworth, 2021, ACS sensors.

Substrates for Investigation of DNA Polymerase Function: Synthesis and Properties of 4′-C-Alkylated Oligonucleotides

A. Marx, D. Summerer, I. Detmer, 2003 .

DNA Polymerase Selectivity: Sugar Interactions Monitored with High-Fidelity Nucleotides This work was supported by a grant from the Deutsche Forschungsgemeinschaft. We thank Professor Dr. Michael Famulok for his continuing support.

A. Marx, D. Summerer, 2001, Angewandte Chemie.

Enhanced fidelity in mismatch extension by DNA polymerase through directed combinatorial enzyme design.

A. Marx, D. Summerer, I. Detmer, 2005, Angewandte Chemie.

Novel Strategies for the Site‐Specific Covalent Labelling of Nucleic Acids

A. Marx, S. Weisbrod, 2009 .

The Structural Basis for Processing of Unnatural Base Pairs by DNA Polymerases

A. Marx, K. Betz, 2020, Chemistry.

KlenTaq polymerase replicates unnatural base pairs by inducing a Watson-Crick geometry

Thomas Lavergne, Phillip Ordoukhanian, Kay Diederichs, 2012, Nature chemical biology.

Nucleotide insertion and bypass synthesis of pyrene- and BODIPY-modified oligonucleotides by DNA polymerases.

A. Marx, H. Wagenknecht, Francesca Di Pasquale, 2008, Chemical communications.

Monitoring enzymatic ATP hydrolysis by EPR spectroscopy.

M. Drescher, A. Marx, C. Hintze, 2014, Chemical communications.

Chemoproteomic discovery of a human RNA ligase

K. Diederichs, M. Scheffner, Florian Stengel, 2023, Nature Communications.

Snapshot of a DNA polymerase while incorporating two consecutive C5-modified nucleotides.

K. Diederichs, W. Welte, A. Marx, 2013, Journal of the American Chemical Society.

Mutant DNA Polymerase for Improved Detection of Single‐Nucleotide Variations in Microarrayed Primer Extension

A. Marx, P. Ketzer, R. Kranaster, 2008, Chembiochem : a European journal of chemical biology.

Five molecules we would take to a remote island.

A. Marx, T. Mayer, 2010, Chemistry & biology.

Solution structure and conformational dynamics of deoxyxylonucleic acids (dXNA): an orthogonal nucleic acid candidate.

P. Herdewijn, A. Ceulemans, Amutha Ramaswamy, 2012, Chemistry.

Artificially Linked Ubiquitin Dimers Characterised Structurally and Dynamically by NMR Spectroscopy

M. Scheffner, A. Marx, M. Kovermann, 2019, Chembiochem : a European journal of chemical biology.

Structural Basis for The Recognition of Deaminated Nucleobases by An Archaeal DNA Polymerase

K. Diederichs, A. Marx, H. Kropp, 2021, Chembiochem : a European journal of chemical biology.

Formation of ubiquitin dimers via azide-alkyne click reaction.

M. Scheffner, M. Rubini, A. Marx, 2012, Methods in molecular biology.

A highly active DNA polymerase with a fluorous core.

M. Rubini, H. Möller, A. Marx, 2010, Angewandte Chemie.

Structural Insights into the Processing of Nucleobase-Modified Nucleotides by DNA Polymerases.

A. Marx, A. Hottin, 2016, Accounts of chemical research.

Chemical trapping of the dynamic MutS-MutL complex formed in DNA mismatch repair in Escherichia coli.

T. Sixma, P. Friedhoff, Luis Giron-Monzon, 2011, The Journal of Biological Chemistry.

An adamantane-based building block for DNA networks.

A. Marx, Richa Pathak, 2011, Chemistry, an Asian journal.

New branched DNA constructs.

S. Keller, C. Gloeckner, A. Marx, 2007, Chemistry.

DNA conjugation by Staudinger ligation.

A. Marx, S. Weisbrod, Anna Baccaro, 2008, Nucleic acids symposium series.

DNA Conjugation by the Staudinger Ligation: New Thymidine Analogues

A. Marx, S. Weisbrod, Anna Baccaro, 2007 .

Human DNA Polymerase β Mutations Allowing Efficient Abasic Site Bypass*

K. Diederichs, W. Welte, A. Marx, 2010, The Journal of Biological Chemistry.

Exploring the Effects of Active Site Constraints on HIV-1 Reverse Transcriptase DNA Polymerase Fidelity*

A. Marx, T. Restle, J. Cramer, 2002, The Journal of Biological Chemistry.