A. Angeli

发表

New Histamine-Related Five-Membered N-Heterocycle Derivatives as Carbonic Anhydrase I Activators

C. Supuran, Niccolò Chiaramonte, Alessio Gabellini, 2022, Molecules.

Expanding the anticancer potential of 1,2,3-triazoles via simultaneously targeting Cyclooxygenase-2, 15-lipoxygenase and tumor-associated carbonic anhydrases.

C. Supuran, A. Eid, A. El-Yazbi, 2020, European journal of medicinal chemistry.

Synthesis, biological evaluation and in silico modelling studies of 1,3,5-trisubstituted pyrazoles carrying benzenesulfonamide as potential anticancer agents and selective cancer-associated hCA IX isoenzyme inhibitors.

C. Supuran, C. Yamali, H. Sakagami, 2019, Bioorganic chemistry.

The influence of storage on the “chemical age” of red wines

F. Mattivi, A. Angeli, D. Perenzoni, 2014, Metabolomics.

Synthesis of coumarin-sulfonamide derivatives and determination of their cytotoxicity, carbonic anhydrase inhibitory and molecular docking studies.

C. Supuran, A. Angeli, B. Zengin Kurt, 2019, European journal of medicinal chemistry.

Screening of benzenesulfonamide in combination with chemically diverse fragments against carbonic anhydrase by differential scanning fluorimetry

C. Supuran, A. Angeli, S. Zozulya, 2019, Journal of enzyme inhibition and medicinal chemistry.

Chagas Disease: Perspectives on the Past and Present and Challenges in Drug Discovery

C. Supuran, A. Angeli, Alane Beatriz Vermelho, 2020, Molecules.

Amine- and Amino Acid-Based Compounds as Carbonic Anhydrase Activators

S. Carradori, C. Supuran, A. Angeli, 2021, Molecules.

Perfluorinated alkylsubstances of significant environmental concern can strongly inhibit human carbonic anhydrase isozymes.

C. Supuran, A. Angeli, A. Nocentini, 2020, Analytical chemistry.

Metabolite profiling of wines made from disease-tolerant varieties

M. Stefanini, F. Mattivi, A. Angeli, 2019, European Food Research and Technology.

Proximate composition, lipid and phenolic profiles, and antioxidant activity of different ecotypes of Lupinus albus, Lupinus luteus and lupinus angustifolius

R. Mhamdi, D. Masuero, A. Angeli, 2020, Journal of Food Measurement and Characterization.

Inoculation of Lupinus albus with the nodule-endophyte Paenibacillus glycanilyticus LJ121 improves grain nutritional quality

R. Mhamdi, D. Masuero, A. Angeli, 2019, Archives of Microbiology.

Synthesis and Biological Evaluation of 4‐Sulfamoylphenyl/Sulfocoumarin Carboxamides as Selective Inhibitors of Carbonic Anhydrase Isoforms hCA II, IX, and XII

C. Supuran, A. Angeli, M. Arifuddin, 2018, ChemMedChem.

Sulfonamide Inhibition Studies of an α-Carbonic Anhydrase from Schistosoma mansoni, a Platyhelminth Parasite Responsible for Schistosomiasis

C. Supuran, M. Pinteala, B. Simionescu, 2020, International journal of molecular sciences.

Lipoyl-Homotaurine Derivative (ADM_12) Reverts Oxaliplatin-Induced Neuropathy and Reduces Cancer Cells Malignancy by Inhibiting Carbonic Anhydrase IX (CAIX).

C. Supuran, V. Calderone, M. Fragai, 2017, Journal of medicinal chemistry.

Tellurides Bearing Sulfonamides as Novel Inhibitors of Leishmanial Carbonic Anhydrase with Potent Antileishmanial Activity.

C. Supuran, A. Azqueta, A. Angeli, 2020, Journal of medicinal chemistry.

Development of Thiazolidinones as Fungal Carbonic Anhydrase Inhibitors

S. Carradori, C. Supuran, R. Grande, 2020, International journal of molecular sciences.

Novel sulfonamides incorporating 1,3,5-triazine and amino acid structural motifs as inhibitors of the physiological carbonic anhydrase isozymes I, II and IV and tumor-associated isozyme IX.

C. Supuran, A. Angeli, Silvia Bua, 2018, Bioorganic chemistry.

Sulfocoumarin‐, Coumarin‐, 4‐Sulfamoylphenyl‐Bearing Indazole‐3‐carboxamide Hybrids: Synthesis and Selective Inhibition of Tumor‐Associated Carbonic Anhydrase Isozymes IX and XII

C. Supuran, A. Angeli, M. Arifuddin, 2017, ChemMedChem.

Inhibitors of Mitochondrial Human Carbonic Anhydrases VA and VB as a Therapeutic Strategy against Paclitaxel-Induced Neuropathic Pain in Mice

C. Supuran, C. Ghelardini, A. Angeli, 2022, International journal of molecular sciences.

Synthesis of 4-(thiazol-2-ylamino)-benzenesulfonamides with carbonic anhydrase I, II and IX inhibitory activity and cytotoxic effects against breast cancer cell lines.

C. Supuran, V. De Luca, C. Capasso, 2016, Bioorganic & medicinal chemistry.

Selective inhibition of carbonic anhydrase IX by sulphonylated 1,2,3-triazole incorporated benzenesulphonamides capable of inducing apoptosis

R. Kumar, C. Supuran, Amit Kumar, 2022, Journal of enzyme inhibition and medicinal chemistry.

New anticancer drug candidates sulfonamides as selective hCA IX or hCA XII inhibitors.

C. Supuran, A. Kazaks, K. Tārs, 2018, Bioorganic chemistry.

Reconsidering anion inhibitors in the general context of drug design studies of modulators of activity of the classical enzyme carbonic anhydrase

S. Carradori, C. Supuran, J. Winum, 2021, Journal of enzyme inhibition and medicinal chemistry.

Mechanisms of action of carbonic anhydrase inhibitors

A. Angeli, M. Tanc, M. Bozdağ, 2019, Carbonic Anhydrases.

Synthesis of N'-phenyl-N-hydroxyureas and investigation of their inhibitory activities on human carbonic anhydrases.

C. Supuran, Z. Alothman, A. Angeli, 2018, Bioorganic chemistry.

Investigation of carbonic anhydrase inhibitory effects and cytotoxicities of pyrazole-based hybrids carrying hydrazone and zinc-binding benzenesulfonamide pharmacophores.

C. Supuran, Y. Uesawa, K. Bandow, 2022, Bioorganic chemistry.

Design, synthesis, and biological evaluation of selective hCA IX inhibitors

D. Vullo, A. Angeli, F. Carta, 2021 .

Structural investigations on coumarins leading to chromeno[4,3-c]pyrazol-4-ones and pyrano[4,3-c]pyrazol-4-ones: New scaffolds for the design of the tumor-associated carbonic anhydrase isoforms IX and XII.

C. Supuran, C. Ghelardini, A. Angeli, 2018, European journal of medicinal chemistry.

3-Hydroxy-1H-quinazoline-2,4-dione as a New Scaffold To Develop Potent and Selective Inhibitors of the Tumor-Associated Carbonic Anhydrases IX and XII.

C. Supuran, C. Ghelardini, A. Angeli, 2017, Journal of medicinal chemistry.

Ionic liquids as an alternative reaction medium for HMDST based synthesis of thioaldehydes

A. Angeli, A. Capperucci, D. Tanini, 2016 .

Sulfonamide Diuretic Azosemide as an Efficient Carbonic Anhydrase Inhibitor

C. Supuran, M. Ferraroni, M. Pinteala, 2022, Journal of Molecular Structure.

Crystal Structure of a Tetrameric Type II β-Carbonic Anhydrase from the Pathogenic Bacterium Burkholderia pseudomallei

C. Supuran, M. Ferraroni, C. Capasso, 2020, Molecules.

X-ray crystallography of Epacadostat in adduct with Carbonic Anhydrase IX.

C. Supuran, T. Peat, A. Angeli, 2020, Bioorganic chemistry.

Synthesis of novel tellurides bearing benzensulfonamide moiety as carbonic anhydrase inhibitors with antitumor activity.

C. Supuran, T. Peat, C. Ghelardini, 2019, European journal of medicinal chemistry.

Crystal structure and chemical inhibition of essential schistosome host-interactive virulence factor carbonic anhydrase SmCA

C. Supuran, M. Ferraroni, A. Angeli, 2019, Communications Biology.

Benzensulfonamides bearing spyrohydantoin moieties act as potent inhibitors of human carbonic anhydrases II and VII and show neuropathic pain attenuating effects.

C. Supuran, T. Peat, C. Ghelardini, 2019, European journal of medicinal chemistry.

Design, synthesis and X-ray crystallography of selenides bearing benzenesulfonamide moiety with neuropathic pain modulating effects.

C. Supuran, T. Peat, C. Ghelardini, 2018, European journal of medicinal chemistry.

Wine metabolomics reveals new sulfonated products in bottled white wines, promoted by small amounts of oxygen.

F. Mattivi, A. Angeli, D. Perenzoni, 2016, Journal of chromatography. A.

Novel insights on saccharin- and acesulfame-based carbonic anhydrase inhibitors: design, synthesis, modelling investigations and biological activity evaluation

S. Carradori, C. Supuran, A. Angeli, 2020, Journal of enzyme inhibition and medicinal chemistry.

Polypharmacology of epacadostat: a potent and selective inhibitor of the tumor associated carbonic anhydrases IX and XII.

C. Supuran, M. Ferraroni, A. Angeli, 2019, Chemical communications.

Discovering a new class of antifungal agents that selectively inhibits microbial carbonic anhydrases

C. Supuran, C. Capasso, A. Angeli, 2018, Journal of enzyme inhibition and medicinal chemistry.

Acyl selenoureido benzensulfonamides show potent inhibitory activity against carbonic anhydrases from the pathogenic bacterium Vibrio cholerae.

C. Supuran, C. Capasso, G. Abbas, 2017, Bioorganic chemistry.

Synthesis and Evaluation of Carbonic Anhydrase Inhibitors with Carbon Monoxide Releasing Properties for the Management of Rheumatoid Arthritis.

C. Supuran, D. Vullo, C. Ghelardini, 2019, Journal of medicinal chemistry.

1,2,4-Triazole-based anticonvulsant agents with additional ROS scavenging activity are effective in a model of pharmacoresistant epilepsy

C. Supuran, K. Musílek, A. Angeli, 2020, Journal of enzyme inhibition and medicinal chemistry.

Lipoyl-Based Antagonists of Transient Receptor Potential Cation A (TRPA1) Downregulate Osteosarcoma Cell Migration and Expression of Pro-Inflammatory Cytokines.

C. Supuran, M. Chatzinikolaidou, A. Angeli, 2022, ACS pharmacology & translational science.

Taurultams incorporating arylsulfonamide: First in vitro inhibition studies of α-, β- and γ-class Carbonic Anhydrases from Vibrio cholerae and Burkholderia pseudomallei.

C. Supuran, C. Capasso, A. Angeli, 2021, European journal of medicinal chemistry.

Dependence on linkers’ flexibility designed for benzenesulfonamides targeting discovery of novel hCA IX inhibitors as potent anticancer agents

C. Supuran, A. Angeli, Alessandro Bonardi, 2022, Journal of enzyme inhibition and medicinal chemistry.

Small Molecule Alkoxy Oriented Selectiveness on Human Carbonic Anhydrase II and IX Inhibition

C. Supuran, A. Angeli, F. Carta, 2022, ChemMedChem.

Novel 2-(2-arylmethylthio-4-chloro-5-methylbenzenesulfonyl)-1-(1,3,5-triazin-2-ylamino)guanidine derivatives: Inhibition of human carbonic anhydrase cytosolic isozymes I and II and the transmembrane tumor-associated isozymes IX and XII, anticancer activity, and molecular modeling studies.

C. Supuran, T. Bączek, A. Angeli, 2018, European journal of medicinal chemistry.

Inhibition of the α-carbonic anhydrase from Vibrio cholerae with amides and sulfonamides incorporating imidazole moieties

C. Supuran, E. Suffredini, C. Capasso, 2017, Journal of enzyme inhibition and medicinal chemistry.

Discovery of a Potent and Highly Selective Dipeptidyl Peptidase IV and Carbonic Anhydrase Inhibitor as “Antidiabesity” Agents Based on Repurposing and Morphing of WB-4101

C. Supuran, R. Matucci, G. Vistoli, 2022, Journal of medicinal chemistry.

The production and biochemical characterization of α-carbonic anhydrase from Lactobacillus rhamnosus GG

C. Supuran, Harlan R. Barker, V. Hytönen, 2022, Applied Microbiology and Biotechnology.

Design, synthesis and biological activity of selective hCAs inhibitors based on 2-(benzylsulfinyl)benzoic acid scaffold

C. De Monte, S. Carradori, C. Supuran, 2019, Journal of enzyme inhibition and medicinal chemistry.

The first activation study of a δ-carbonic anhydrase: TweCAδ from the diatom Thalassiosira weissflogii is effectively activated by amines and amino acids

C. Supuran, C. Capasso, Z. Alothman, 2018, Journal of enzyme inhibition and medicinal chemistry.

Effect of Carbonic Anhydrase IX inhibitors on human endothelial cell survival.

C. Supuran, L. Morbidelli, A. Angeli, 2020, Pharmacological research.

Thiosemicarbazide-Substituted Coumarins as Selective Inhibitors of the Tumor Associated Human Carbonic Anhydrases IX and XII

C. Supuran, A. Angeli, F. Carta, 2022, Molecules.

Heterobimetallic complexes containing organometallic acylhydrazone ligands as potential inhibitors of human carbonic anhydrases.

C. Supuran, A. Angeli, Claudio A. Jiménez, 2022, Journal of inorganic biochemistry.

Novel 2-indolinones containing a sulfonamide moiety as selective inhibitors of candida β-carbonic anhydrase enzyme

C. Supuran, A. Angeli, N. Karalı, 2019, Journal of enzyme inhibition and medicinal chemistry.

Novel Indole-Based Hydrazones as Potent Inhibitors of the α-class Carbonic Anhydrase from Pathogenic Bacterium Vibrio cholerae

C. Supuran, A. Angeli, Özlen Güzel-Akdemir, 2020, International journal of molecular sciences.

Glyco-Coated CdSe/ZnS Quantum Dots as Nanoprobes for Carbonic Anhydrase IX Imaging in Cancer Cells

C. Supuran, M. Marelli, C. Ghelardini, 2021, ACS Applied Nano Materials.

Tellurides bearing benzensulfonamide as carbonic anhydrase inhibitors with potent antitumor activity.

C. Supuran, C. Ghelardini, M. Pinteala, 2021, Bioorganic & medicinal chemistry letters.

Inhibition studies on carbonic anhydrase isoforms I, II, IV and IX with N-arylsubstituted secondary sulfonamides featuring a bicyclic tetrahydroindazole scaffold.

E. Novellino, F. Da Settimo, S. Taliani, 2021, European journal of medicinal chemistry.

Seleno Containing Compounds as Potent and Selective Antifungal Agents

C. Supuran, C. Capasso, A. Angeli, 2022, ACS infectious diseases.

Exploring new structural features of the 4-[(3-methyl-4-aryl-2,3-dihydro-1,3-thiazol-2-ylidene)amino]benzenesulphonamide scaffold for the inhibition of human carbonic anhydrases

C. Supuran, C. Capasso, A. Angeli, 2019, Journal of enzyme inhibition and medicinal chemistry.

Prostaglandin receptor agonists as antiglaucoma agents (a patent review 2013 – 2018)

C. Supuran, A. Angeli, 2019, Expert opinion on therapeutic patents.

New β-arylchalcogeno amines with procognitive properties targeting Carbonic Anhydrases and Monoamine Oxidases.

S. Carradori, C. Supuran, D. Vullo, 2022, European journal of medicinal chemistry.

Synthesis and biological evaluation of novel 4, 7-disubstituted coumarins as selective tumor-associated carbonic anhydrase IX and XII inhibitors.

C. Supuran, K. Chandra, A. Angeli, 2021, Bioorganic & medicinal chemistry letters.

Synthesis and anticancer activity of new benzensulfonamides incorporating s-triazines as cyclic linkers for inhibition of carbonic anhydrase IX

C. Supuran, A. Angeli, T. El-Moselhy, 2022, Scientific Reports.

The effect of soybean oil quality and vitamin E supplementation on turkey diet nutrition

A. Angeli, A. Maiorka, A. Silva, 2012 .

Design, synthesis, biological evaluation and crystal structure determination of dual modulators of carbonic anhydrases and estrogen receptors.

G. Rastelli, J. Nwachukwu, K. Nettles, 2022, European journal of medicinal chemistry.

Identification of New Carbonic Anhydrase VII Inhibitors by Structure-Based Virtual Screening

A. Talevi, C. Supuran, D. Vullo, 2022, J. Chem. Inf. Model..

Discovery of 4-sulfamoyl-phenyl-β-lactams as a new class of potent carbonic anhydrase isoforms I, II, IV and VII inhibitors: The first example of subnanomolar CA IV inhibitors.

S. M. Monti, A. Angeli, Mallika Alvala, 2017, Bioorganic & medicinal chemistry.

Pharmacological Inhibition of CA-IX Impairs Tumor Cell Proliferation, Migration and Invasiveness

C. Supuran, L. Morbidelli, A. Angeli, 2020, International journal of molecular sciences.

Spirocyclic sulfonamides with carbonic anhydrase inhibitory and anti-neuropathic pain activity.

Abdul-Malek S. Al-Tamimi, C. Supuran, C. Ghelardini, 2019, Bioorganic chemistry.

2-(2-Hydroxyethyl)piperazine derivatives as potent human carbonic anhydrase inhibitors: Synthesis, enzyme inhibition, computational studies and Antiglaucoma activity

C. Supuran, Niccolò Chiaramonte, A. Angeli, 2021, European Journal of Medicinal Chemistry.

Carbonic Anhydrase Inhibition with Sulfonamides Incorporating Pyrazole- and Pyridazinecarboxamide Moieties Provides Examples of Isoform-Selective Inhibitors

C. Supuran, M. Pinteala, A. Angeli, 2021, Molecules.

First evaluation of organotellurium derivatives as carbonic anhydrase I, II, IV, VII and IX inhibitors.

C. Supuran, A. Angeli, A. Capperucci, 2018, Bioorganic chemistry.

Tail approach synthesis of novel benzenesulfonamides incorporating 1,3,4-oxadiazole hybrids as potent inhibitor of carbonic anhydrase I, II, IX, and XII isoenzymes.

R. Kumar, C. Supuran, A. Angeli, 2020, European journal of medicinal chemistry.

Iodine-mediated one-pot intramolecular decarboxylation domino reaction for accessing functionalised 2-(1,3,4-oxadiazol-2-yl)anilines with carbonic anhydrase inhibitory action

C. Supuran, A. Angeli, N. Nagesh, 2018, Journal of enzyme inhibition and medicinal chemistry.

Novel benzenesulfonamide‐bearing pyrazoles and 1,2,4‐thiadiazoles as selective carbonic anhydrase inhibitors

R. Kumar, C. Supuran, A. Angeli, 2021, Archiv der Pharmazie.

Investigation on Hydrazonobenzenesulfonamides as Human Carbonic Anhydrase I, II, IX and XII Inhibitors

C. Supuran, G. Balboni, A. Angeli, 2022, Molecules.

Synthesis of Sulfonamides Incorporating Piperidinyl-Hydrazidoureido and Piperidinyl-Hydrazidothioureido Moieties and Their Carbonic Anhydrase I, II, IX and XII Inhibitory Activity

C. Supuran, G. Balboni, A. Angeli, 2022, Molecules.

Comprehensive study on potent and selective carbonic anhydrase inhibitors: Synthesis, bioactivities and molecular modelling studies of 4-(3-(2-arylidenehydrazine-1-carbonyl)-5-(thiophen-2-yl)-1H-pyrazole-1-yl) benzenesulfonamides.

C. Supuran, Y. Uesawa, C. Yamali, 2021, European journal of medicinal chemistry.

Carbonic Anhydrase Inhibitors Targeting Metabolism and Tumor Microenvironment

S. Carradori, C. Supuran, S. Dedhar, 2020, Metabolites.

Sulfonamides incorporating piperazine bioisosteres as potent human carbonic anhydrase I, II, IV and IX inhibitors.

C. Supuran, M. Ferraroni, Niccolò Chiaramonte, 2019, Bioorganic chemistry.

Novel 1,3,5-Triazinyl Aminobenzenesulfonamides Incorporating Aminoalcohol, Aminochalcone and Aminostilbene Structural Motifs as Potent Anti-VRE Agents, and Carbonic Anhydrases I, II, VII, IX, and XII Inhibitors

C. Supuran, M. Brázdová, J. Jampílek, 2021, International journal of molecular sciences.

Chromene-Containing Aromatic Sulfonamides with Carbonic Anhydrase Inhibitory Properties

C. Supuran, M. Pinteala, A. Angeli, 2021, International journal of molecular sciences.

Benzenesulfonamides with trisubstituted triazole motif as selective carbonic anhydrase I, II, IV, and IX inhibitors

R. Kumar, C. Supuran, A. Angeli, 2022, Archiv der Pharmazie.

N-Acylbenzenesulfonamide Dihydro-1,3,4-oxadiazole Hybrids: Seeking Selectivity toward Carbonic Anhydrase Isoforms

C. Supuran, M. Gaspari, A. Kazaks, 2017, ACS medicinal chemistry letters.

Design, synthesis and biological evaluation of coumarin linked 1,2,4-oxadiazoles as selective carbonic anhydrase IX and XII inhibitors.

C. Supuran, A. Angeli, Pavitra S Thacker, 2020, Bioorganic chemistry.

Coumarin-Based Dual Inhibitors of Human Carbonic Anhydrases and Monoamine Oxidases Featuring Amino Acyl and (Pseudo)-Dipeptidyl Appendages: In Vitro and Computational Studies

S. Carradori, C. Supuran, Mariangela Agamennone, 2022, Molecules.

Selective inhibition of carbonic anhydrase IX and XII by coumarin and psoralen derivatives

C. Supuran, A. Angeli, D. Secci, 2021, Journal of enzyme inhibition and medicinal chemistry.

Benzylaminoethyureido-Tailed Benzenesulfonamides: Design, Synthesis, Kinetic and X-ray Investigations on Human Carbonic Anhydrases

U. Farooq, C. Supuran, G. Zanotti, 2020, International journal of molecular sciences.

Coumarins from Magydaris pastinacea as inhibitors of the tumour-associated carbonic anhydrases IX and XII: isolation, biological studies and in silico evaluation

P. Caboni, C. Supuran, A. Angeli, 2020, Journal of enzyme inhibition and medicinal chemistry.

Targeting Tumor Associated Carbonic Anhydrases IX and XII: Highly Isozyme Selective Coumarin and Psoralen Inhibitors.

C. Supuran, M. Gaspari, C. Capasso, 2018, ACS medicinal chemistry letters.

Synthesis carbonic anhydrase enzyme inhibition and antioxidant activity of novel benzothiazole derivatives incorporating glycine, methionine, alanine, and phenylalanine moieties

C. Supuran, A. Angeli, F. Küçükbay, 2018, Journal of enzyme inhibition and medicinal chemistry.

Synthesis and carbonic anhydrase activating properties of a series of 2-amino-imidazolines structurally related to clonidine1

C. Supuran, Niccolò Chiaramonte, A. Angeli, 2020, Journal of enzyme inhibition and medicinal chemistry.

Coumarin‐Thiourea Hybrids Show Potent Carbonic Anhydrase IX and XIII Inhibitory Action

C. Supuran, A. Angeli, Priti Singh, 2020, ChemMedChem.

Pyrazolo[4,3-c]pyridine Sulfonamides as Carbonic Anhydrase Inhibitors: Synthesis, Biological and In Silico Studies

C. Supuran, M. Pinteala, A. Angeli, 2022, Pharmaceuticals.

Synthesis and Biological Evaluation of Imidazo[2,1-b]Thiazole based Sulfonyl Piperazines as Novel Carbonic Anhydrase II Inhibitors

C. Supuran, A. Angeli, Mallika Alvala, 2020, Metabolites.

4-Anilinoquinazoline-based benzenesulfonamides as nanomolar inhibitors of carbonic anhydrase isoforms I, II, IX, and XII: design, synthesis, in-vitro, and in-silico biological studies

C. Supuran, A. Angeli, Hossam Nada, 2022, Journal of enzyme inhibition and medicinal chemistry.

Discovery of New Selenoureido Analogues of 4-(4-Fluorophenylureido)benzenesulfonamide as Carbonic Anhydrase Inhibitors.

C. Supuran, T. Peat, C. Ghelardini, 2017, ACS medicinal chemistry letters.

Inhibition of the β-carbonic anhydrase from the protozoan pathogen Trichomonas vaginalis with sulphonamides

C. Supuran, V. Hytönen, A. Angeli, 2020, Journal of enzyme inhibition and medicinal chemistry.

New coumarin/sulfocoumarin linked phenylacrylamides as selective transmembrane carbonic anhydrase inhibitors: Synthesis and in-vitro biological evaluation.

C. Supuran, A. Angeli, Priti Singh, 2020, Bioorganic & medicinal chemistry.

Design, Synthesis, and Biological Evaluation of 1,2,3-Triazole-linked triazino[5,6-b]indole-benzene sulfonamide Conjugates as Potent Carbonic Anhydrase I, II, IX, and XIII Inhibitors

C. Supuran, A. Angeli, Pavitra S Thacker, 2020, Metabolites.

Synthesis and biological evaluation of coumarin-1,3,4-oxadiazole hybrids as selective carbonic anhydrase IX and XII inhibitors.

C. Supuran, A. Angeli, Mallika Alvala, 2019, Bioorganic chemistry.

Design, synthesis and biological evaluation of coumarin-3-carboxamides as selective carbonic anhydrase IX and XII inhibitors.

C. Supuran, A. Angeli, Mallika Alvala, 2019, Bioorganic chemistry.

Synthesis, biological activity and multiscale molecular modeling studies of bis-coumarins as selective carbonic anhydrase IX and XII inhibitors with effective cytotoxicity against hepatocellular carcinoma.

C. Supuran, S. Durdağı, A. Angeli, 2019, Bioorganic chemistry.

Synthesis, biological activity and multiscale molecular modeling studies for coumaryl-carboxamide derivatives as selective carbonic anhydrase IX inhibitors

C. Supuran, S. Durdağı, A. Angeli, 2017, Journal of enzyme inhibition and medicinal chemistry.

Synthesis of novel 4-functionalized 1,5-diaryl-1,2,3-triazoles containing benzenesulfonamide moiety as carbonic anhydrase I, II, IV and IX inhibitors.

R. Kumar, C. Supuran, A. Angeli, 2018, European journal of medicinal chemistry.

Synthesis and biological evaluation of cyclic imides incorporating benzenesulfonamide moieties as carbonic anhydrase I, II, IV and IX inhibitors.

C. Supuran, A. Angeli, A. Abdel-Aziz, 2017, Bioorganic & medicinal chemistry.

Fluoroenesulphonamides: N-sulphonylurea isosteres showing nanomolar selective cancer-related transmembrane human carbonic anhydrase inhibition

C. Supuran, A. Angeli, G. Evano, 2018, Journal of enzyme inhibition and medicinal chemistry.

Synthesis of Novel Selenides Bearing Benzenesulfonamide Moieties as Carbonic Anhydrase I, II, IV, VII, and IX Inhibitors.

C. Supuran, A. Angeli, A. Capperucci, 2017, ACS medicinal chemistry letters.

Sulfur, selenium and tellurium containing amines act as effective carbonic anhydrase activators.

C. Supuran, A. Angeli, A. Capperucci, 2019, Bioorganic chemistry.

Inhibition of bacterial α-, β- and γ-class carbonic anhydrases with selenazoles incorporating benzenesulfonamide moieties

C. Supuran, C. Capasso, M. Pinteala, 2018, Journal of enzyme inhibition and medicinal chemistry.

Microwave-assisted extraction, HPLC analysis, and inhibitory effects on carbonic anhydrase I, II, VA, and VII isoforms of 14 blueberry Italian cultivars

S. Carradori, A. Mollica, C. Supuran, 2016, Journal of enzyme inhibition and medicinal chemistry.

Direct and straightforward access to substituted alkyl selenols as novel carbonic anhydrase inhibitors.

C. Supuran, M. Ferraroni, A. Angeli, 2019, European journal of medicinal chemistry.

Syntesis of thio- and seleno-acetamides bearing benzenesulfonamide as potent inhibitors of human carbonic anhydrase II and XII.

C. Supuran, A. Angeli, A. Capperucci, 2019, Bioorganic chemistry.

Synthesis of different thio-scaffolds bearing sulfonamide with subnanomolar carbonic anhydrase II and IX inhibitory properties and X-ray investigations for their inhibitory mechanism.

F. Turco, C. Supuran, M. Ferraroni, 2018, Bioorganic chemistry.

Evaluation of selenide, diselenide and selenoheterocycle derivatives as carbonic anhydrase I, II, IV, VII and IX inhibitors.

S. Menichetti, C. Supuran, C. Viglianisi, 2017, Bioorganic & medicinal chemistry.

Discovery of Benzenesulfonamides with Potent Human Carbonic Anhydrase Inhibitory and Effective Anticonvulsant Action: Design, Synthesis, and Pharmacological Assessment.

C. B. Mishra, C. Supuran, S. M. Monti, 2017, Journal of medicinal chemistry.

Improvement of sea fennel (Crithmum maritimum L.) nutritional value through iodine biofortification in a hydroponic floating system.

P. Chatzopoulou, A. Angeli, A. Siomos, 2019, Food chemistry.

Evaluation of parsley (Petroselinum crispum) germplasm diversity from the Greek Gene Bank using morphological, molecular and metabolic markers

A. Kalivas, Ioannis Ganopoulos, A. Xanthopoulou, 2021 .

Activation of the β-carbonic anhydrase from the protozoan pathogen Trichomonas vaginalis with amines and amino acids

C. Supuran, V. Hytönen, A. Angeli, 2021, Journal of enzyme inhibition and medicinal chemistry.

Sulfonamide Inhibition Profile of the β-Carbonic Anhydrase from Malassezia restricta, An Opportunistic Pathogen Triggering Scalp Conditions

C. Supuran, C. Capasso, A. Angeli, 2020, Metabolites.

Phenols from Origanum dictamnus L. and Thymus vulgaris L. and their activity against Malassezia globosa carbonic anhydrase

C. Supuran, C. Capasso, A. Angeli, 2021, Natural product research.

Biological investigation of N-methyl thiosemicarbazones as antimicrobial agents and bacterial carbonic anhydrases inhibitors

S. Carradori, C. Supuran, R. Venanzoni, 2022, Journal of enzyme inhibition and medicinal chemistry.

Activation studies with amino acids and amines of a β-carbonic anhydrase from Mammaliicoccus (Staphylococcus) sciuri previously annotated as Staphylococcus aureus (SauBCA) carbonic anhydrase

C. Supuran, C. Capasso, A. Angeli, 2022, Journal of enzyme inhibition and medicinal chemistry.

Selective Inhibition of Helicobacter pylori Carbonic Anhydrases by Carvacrol and Thymol Could Impair Biofilm Production and the Release of Outer Membrane Vesicles

S. Carradori, C. Supuran, V. De Luca, 2021, International journal of molecular sciences.

De novo transcriptome assembly and functional analysis reveal a dihydrochalcone 3-hydroxylase(DHC3H) of wild Malus species that produces sieboldin in vivo

M. Malnoy, R. Espley, A. Angeli, 2022, Frontiers in Plant Science.

Synthesis and Biological Evaluation of Coumarin-Linked 4-Anilinomethyl-1,2,3-Triazoles as Potent Inhibitors of Carbonic Anhydrases IX and XIII Involved in Tumorigenesis

C. Supuran, A. Angeli, B. Swain, 2021, Metabolites.

Isatin: a privileged scaffold for the design of carbonic anhydrase inhibitors

C. Supuran, C. Capasso, A. Angeli, 2016, Journal of enzyme inhibition and medicinal chemistry.

Bioactive isoflavones from Pueraria lobata root and starch: Different extraction techniques and carbonic anhydrase inhibition.

S. Carradori, A. Mollica, C. Supuran, 2017, Food and chemical toxicology : an international journal published for the British Industrial Biological Research Association.

The influence of storage on the “chemical age” of red wines

F. Mattivi, A. Angeli, D. Perenzoni, 2014, Metabolomics.

Exploring structural properties of potent human carbonic anhydrase inhibitors bearing a 4-(cycloalkylamino-1-carbonyl)benzenesulfonamide moiety.

C. Supuran, E. Russo, S. Ferro, 2019, European journal of medicinal chemistry.

New Sulfanilamide Derivatives Incorporating Heterocyclic Carboxamide Moieties as Carbonic Anhydrase Inhibitors

C. Supuran, V. De Luca, C. Capasso, 2021, Pharmaceuticals.

Glycomimetic Based Approach toward Selective Carbonic Anhydrase Inhibitors.

C. Supuran, A. Angeli, C. Matassini, 2020, ACS medicinal chemistry letters.

Synthesis of Azasugar–Sulfonamide conjugates and their Evaluation as Inhibitors of Carbonic Anhydrases: the Azasugar Approach to Selectivity

C. Supuran, M. Ferraroni, A. Angeli, 2021 .

Discovery of new organoselenium compounds as antileishmanial agents.

Abdul-Malek S. Al-Tamimi, C. Supuran, A. Angeli, 2019, Bioorganic chemistry.

Azidothymidine “Clicked” into 1,2,3-Triazoles: First Report on Carbonic Anhydrase–Telomerase Dual-Hybrid Inhibitors

S. Carradori, C. Supuran, T. Peat, 2020, Journal of medicinal chemistry.

Synthesis of novel acyl selenoureido benzensulfonamides as carbonic anhydrase I, II, VII and IX inhibitors.

C. Supuran, A. Angeli, G. Bartolucci, 2017, Bioorganic & medicinal chemistry.

Activation Effects of Carnosine- and Histidine-Containing Dipeptides on Human Carbonic Anhydrases: A Comprehensive Study

G. Aldini, C. Supuran, G. Vistoli, 2020, International journal of molecular sciences.

A structure-based approach towards the identification of novel antichagasic compounds: Trypanosoma cruzi carbonic anhydrase inhibitors

Maria L. Villalba, A. Talevi, C. Supuran, 2019, Journal of enzyme inhibition and medicinal chemistry.

Inhibition of carbonic anhydrases by a substrate analog: benzyl carbamate directly coordinates the catalytic zinc ion mimicking bicarbonate binding.

C. Supuran, J. Winum, A. Angeli, 2018, Chemical communications.

Activation studies with amines and amino acids of the β-carbonic anhydrase from the pathogenic protozoan Leishmania donovani chagasi.

C. Supuran, A. Angeli, S. Parkkila, 2018, Bioorganic chemistry.

Discovery of potent anti-convulsant carbonic anhydrase inhibitors: Design, synthesis, in vitro and in vivo appraisal.

C. B. Mishra, C. Supuran, A. Angeli, 2018, European journal of medicinal chemistry.

Discovery of Benzenesulfonamide Derivatives as Carbonic Anhydrase Inhibitors with Effective Anticonvulsant Action: Design, Synthesis, and Pharmacological Evaluation.

C. B. Mishra, C. Supuran, A. Angeli, 2018, Journal of medicinal chemistry.

Quinoline-sulfamoyl carbamates/sulfamide derivatives: Synthesis, cytotoxicity, carbonic anhydrase activity, and molecular modelling studies.

C. Supuran, A. Angeli, B. Zengin Kurt, 2021, Bioorganic chemistry.

Tuning the Dual Inhibition of Carbonic Anhydrase and Cyclooxygenase by Dihydrothiazole Benzensulfonamides.

C. Supuran, M. Gaspari, C. Capasso, 2018, ACS medicinal chemistry letters.

Probing Molecular Interactions between Human Carbonic Anhydrases (hCAs) and a Novel Class of Benzenesulfonamides.

C. Supuran, S. Ferro, A. Angeli, 2017, Journal of medicinal chemistry.

Carbonic anhydrase activation profile of indole-based derivatives

F. Da Settimo, S. Taliani, C. Martini, 2021, Journal of enzyme inhibition and medicinal chemistry.

The first activation studies of the η-carbonic anhydrase from the malaria parasite Plasmodium falciparum with amines and amino acids.

C. Supuran, C. Capasso, Z. Alothman, 2018, Bioorganic chemistry.

Resveratrol Analogues as Dual Inhibitors of Monoamine Oxidase B and Carbonic Anhydrase VII: A New Multi-Target Combination for Neurodegenerative Diseases?

S. Carradori, C. Supuran, Mariangela Agamennone, 2022, Molecules.

Click chemistry approaches for developing carbonic anhydrase inhibitors and their applications

C. Supuran, A. Angeli, 2023, Journal of enzyme inhibition and medicinal chemistry.

Schiff bases as linker in the development of quinoline-sulfonamide hybrids as selective cancer-associated carbonic anhydrase isoforms IX/XII inhibitors: A new regioisomerism tactic.

C. Supuran, Ehab S. Taher, A. Angeli, 2022, Bioorganic chemistry.

Design, Synthesis and Biological Assessment of Rhodanine-Linked Benzenesulfonamide Derivatives as Selective and Potent Human Carbonic Anhydrase Inhibitors

S. Carradori, C. Supuran, A. Angeli, 2022, Molecules.

Development of benzene and benzothiazole-sulfonamide analogues as selective inhibitors of the tumor-associated carbonic anhydrase IX.

S. Carradori, C. Supuran, A. Angeli, 2022, European journal of medicinal chemistry.

Novel Insights on Human Carbonic Anhydrase Inhibitors Based on Coumalic Acid: Design, Synthesis, Molecular Modeling Investigation, and Biological Studies

S. Carradori, C. Supuran, A. Ciogli, 2022, International journal of molecular sciences.

1,3-Dipolar cycloaddition, HPLC enantioseparation and docking studies of saccharin/isoxazole and saccharin/isoxazoline derivatives as selective carbonic anhydrase IX and XII inhibitors.

S. Carradori, C. Supuran, T. Tuccinardi, 2020, Journal of medicinal chemistry.

Psychoactive substances belonging to the amphetamine class potently activate brain carbonic anhydrase isoforms VA, VB, VII, and XII

C. Supuran, A. Angeli, E. Bertol, 2017, Journal of enzyme inhibition and medicinal chemistry.

Synthesis and biological evaluation of novel 8-substituted quinoline-2-carboxamides as carbonic anhydrase inhibitors

C. Supuran, A. Angeli, Pavitra S Thacker, 2019, Journal of enzyme inhibition and medicinal chemistry.

Heterologous expression and biochemical characterisation of the recombinant β-carbonic anhydrase (MpaCA) from the warm-blooded vertebrate pathogen malassezia pachydermatis

A. Scaloni, C. Supuran, V. De Luca, 2021, Journal of enzyme inhibition and medicinal chemistry.

Inhibitory Effects of Sulfonamide Derivatives on the β-Carbonic Anhydrase (MpaCA) from Malassezia pachydermatis, a Commensal, Pathogenic Fungus Present in Domestic Animals

A. Scaloni, C. Supuran, V. De Luca, 2021, International journal of molecular sciences.

N-aryl-N'-ureido-O-sulfamates: Potent and selective inhibitors of the human Carbonic Anhydrase VII isoform with neuropathic pain relieving properties.

C. Supuran, J. Winum, C. Ghelardini, 2019, Bioorganic chemistry.

Benzamide-4-Sulfonamides Are Effective Human Carbonic Anhydrase I, II, VII, and IX Inhibitors

C. Supuran, A. Angeli, M. Bozdağ, 2018, Metabolites.

Synthesis and carbonic anhydrase I, II, VII, and IX inhibition studies with a series of benzo[d]thiazole-5- and 6-sulfonamides

C. Supuran, A. Angeli, F. Carta, 2017, Journal of enzyme inhibition and medicinal chemistry.

Carbonic Anhydrase inhibitors bearing organotelluride moieties as novel agents for antitumor therapy.

C. Supuran, M. Pinteala, A. Fifere, 2022, European journal of medicinal chemistry.

One-Pot Procedure for the Synthesis of Asymmetric Substituted Ureido Benzene Sulfonamides as Effective Inhibitors of Carbonic Anhydrase Enzymes.

C. Supuran, E. Masini, M. Ferraroni, 2021, Journal of medicinal chemistry.

Sulphonamide inhibition profile of Staphylococcus aureus β-carbonic anhydrase

C. Supuran, V. Hytönen, A. Angeli, 2020, Journal of enzyme inhibition and medicinal chemistry.

Synthesis and carbonic anhydrase inhibition studies of sulfonamide based indole-1,2,3-triazole chalcone hybrids.

C. Supuran, A. Angeli, Priti Singh, 2020, Bioorganic chemistry.

Crystal structure and chemical inhibition of essential schistosome host-interactive virulence factor carbonic anhydrase SmCA

C. Supuran, M. Ferraroni, A. Angeli, 2019, Communications Biology.

Synthesis of a new series of 3-functionalised-1-phenyl-1,2,3-triazole sulfamoylbenzamides as carbonic anhydrase I, II, IV and IX inhibitors

C. Supuran, A. Angeli, Priti Singh, 2019, Journal of enzyme inhibition and medicinal chemistry.

Development of Praziquantel sulphonamide derivatives as antischistosomal drugs

J. Keiser, C. Supuran, M. Ferraroni, 2022, Journal of enzyme inhibition and medicinal chemistry.

Inhibition of Schistosoma mansoni carbonic anhydrase by the antiparasitic drug clorsulon: X-ray crystallographic and in vitro studies

S. Carradori, C. Supuran, M. Ferraroni, 2022, Acta crystallographica. Section D, Structural biology.

Biochemical and structural characterization of beta-carbonic anhydrase from the parasite Trichomonas vaginalis

C. Supuran, V. Hytönen, Latifeh Azizi, 2021, Journal of molecular medicine.

Structural Insights into Schistosoma mansoni Carbonic Anhydrase (SmCA) Inhibition by Selenoureido-Substituted Benzenesulfonamides.

C. Supuran, M. Ferraroni, M. Pinteala, 2021, Journal of medicinal chemistry.

Discovery of Potent Carbonic Anhydrase Inhibitors as Effective Anticonvulsant Agents: Drug Design, Synthesis, and In Vitro and In Vivo Investigations.

C. B. Mishra, C. Supuran, R. Mongre, 2021, Journal of medicinal chemistry.

Development of sulfonamides incorporating phenylacrylamido functionalities as carbonic anhydrase isoforms I, II, IX and XII inhibitors.

C. Supuran, C. Capasso, A. Angeli, 2017, Bioorganic & medicinal chemistry.

Synthesis of a new series of quinoline/pyridine indole-3-sulfonamide hybrids as selective carbonic anhydrase IX inhibitors.

C. Supuran, A. Angeli, B. Swain, 2022, Bioorganic & medicinal chemistry letters.

Exploration of 2-phenylquinoline-4-carboxamide linked benzene sulfonamide derivatives as isoform selective inhibitors of transmembrane human carbonic anhydrases.

C. Supuran, A. Angeli, Priti Singh, 2022, European journal of medicinal chemistry.

Identification of Novel and Potent Indole-Based Benzenesulfonamides as Selective Human Carbonic Anhydrase II Inhibitors: Design, Synthesis, In Vitro, and In Silico Studies

C. Supuran, A. Angeli, Hossam Nada, 2022, International journal of molecular sciences.

Design and development of novel series of indole‐3‐sulfonamide ureido derivatives as selective carbonic anhydrase II inhibitors

C. Supuran, A. Angeli, Priti Singh, 2021, Archiv der Pharmazie.

Discovery of a novel series of indolylchalcone-benzenesulfonamide hybrids acting as selective carbonic anhydrase II inhibitors.

C. Supuran, A. Angeli, Priti Singh, 2021, Bioorganic chemistry.

Vasodilation of Pre-contracted Porcine Retinal Arteries by Carbonic Anhydrase Inhibitors with Enhanced Lipophilicity

C. Supuran, A. Angeli, F. Carta, 2022, Current eye research.

Biochemical and structural characterisation of a protozoan beta-carbonic anhydrase from Trichomonas vaginalis

C. Supuran, V. Hytönen, Latifeh Azizi, 2020, Journal of enzyme inhibition and medicinal chemistry.

Activation studies with amines and amino acids of the α-carbonic anhydrase from the pathogenic protozoan Trypanosoma cruzi.

C. Supuran, A. Angeli, S. Parkkila, 2018, Bioorganic & medicinal chemistry.

Tail-Approach-Based Design and Synthesis of Coumarin-Monoterpenes as Carbonic Anhydrase Inhibitors and Anticancer Agents

C. Supuran, A. Angeli, B. Zengin Kurt, 2023, ACS omega.

Discovery of Novel Nonsteroidal Anti-Inflammatory Drugs and Carbonic Anhydrase Inhibitors Hybrids (NSAIDs-CAIs) for the Management of Rheumatoid Arthritis.

C. Supuran, A. Scozzafava, D. Vullo, 2018, Journal of medicinal chemistry.

Synthesis, Computational Studies and Assessment of in Vitro Activity of Squalene Derivatives as Carbonic Anhydrase Inhibitors

C. Supuran, M. Pinteala, A. Angeli, 2020, ChemMedChem.

The first activation study of the β-carbonic anhydrases from the pathogenic bacteria Brucella suis and Francisella tularensis with amines and amino acids

C. Supuran, C. Capasso, M. Pinteala, 2019, Journal of enzyme inhibition and medicinal chemistry.

The zinc - but not cadmium - containing ζ-carbonic from the diatom Thalassiosira weissflogii is potently activated by amines and amino acids.

C. Supuran, A. Angeli, W. Donald, 2018, Bioorganic chemistry.

The γ-carbonic anhydrase from the pathogenic bacterium Vibrio cholerae is potently activated by amines and amino acids.

C. Supuran, C. Capasso, A. Angeli, 2018, Bioorganic chemistry.

Activation of β- and γ-carbonic anhydrases from pathogenic bacteria with tripeptides

A. Mollica, C. Supuran, C. Capasso, 2018, Journal of enzyme inhibition and medicinal chemistry.

Activation studies with amines and amino acids of the β-carbonic anhydrase encoded by the Rv3273 gene from the pathogenic bacterium Mycobacterium tuberculosis

C. Supuran, C. Capasso, Z. Alothman, 2018, Journal of enzyme inhibition and medicinal chemistry.

Investigation of piperazines as human carbonic anhydrase I, II, IV and VII activators

C. Supuran, Niccolò Chiaramonte, A. Angeli, 2017, Journal of enzyme inhibition and medicinal chemistry.

Five- and Six-Membered Nitrogen-Containing Compounds as Selective Carbonic Anhydrase Activators

S. Carradori, A. Mollica, C. Supuran, 2017, Molecules.

Synthesis and biological evaluation of some coumarin hybrids as selective carbonic anhydrase IX and XII inhibitors.

C. Supuran, A. Angeli, Mallika Alvala, 2020, Bioorganic chemistry.

Discovery of curcumin inspired sulfonamide derivatives as a new class of carbonic anhydrase isoforms I, II, IX, and XII inhibitors

C. Supuran, A. Angeli, A. Kamal, 2017, Journal of enzyme inhibition and medicinal chemistry.

Response to Perspectives on the Classical Enzyme Carbonic Anhydrase and the Search for Inhibitors.

S. Carradori, C. Supuran, S. Dedhar, 2020, Biophysical journal.

Design, synthesis and biochemical evaluation of novel carbonic anhydrase inhibitors triggered by structural knowledge on hCA VII.

C. Supuran, A. Angeli, R. Gitto, 2021, Bioorganic & medicinal chemistry.

In Silico-Guided Identification of New Potent Inhibitors of Carbonic Anhydrases Expressed in Vibrio cholerae.

C. Supuran, C. Capasso, A. Angeli, 2020, ACS medicinal chemistry letters.

Looking toward the Rim of the Active Site Cavity of Druggable Human Carbonic Anhydrase Isoforms.

C. Supuran, A. Angeli, R. Gitto, 2020, ACS medicinal chemistry letters.

Inhibitory effects and structural insights for a novel series of coumarin-based compounds that selectively target human CA IX and CA XII carbonic anhydrases.

C. Supuran, C. Capasso, S. Ferro, 2018, European journal of medicinal chemistry.

Activation studies of the α- and β-carbonic anhydrases from the pathogenic bacterium Vibrio cholerae with amines and amino acids

C. Supuran, C. Capasso, Z. Alothman, 2017, Journal of enzyme inhibition and medicinal chemistry.

Discovery of New Potential Anti‐Infective Compounds Based on Carbonic Anhydrase Inhibitors by Rational Target‐Focused Repurposing Approaches

C. Supuran, D. Vullo, C. Capasso, 2016, ChemMedChem.

First-in-Class Dual Hybrid Carbonic Anhydrase Inhibitors and Transient Receptor Potential Vanilloid 1 Agonists Revert Oxaliplatin-Induced Neuropathy

C. Supuran, M. Ferraroni, C. Ghelardini, 2023, Journal of medicinal chemistry.

Inhibition of the newly discovered β‑carbonic anhydrase from the protozoan pathogen Trichomonas vaginalis with inorganic anions and small molecules.

C. Supuran, V. Hytönen, A. Angeli, 2020, Journal of inorganic biochemistry.

Preparation, carbonic anhydrase enzyme inhibition and antioxidant activity of novel 7-amino-3,4-dihydroquinolin-2(1H)-one derivatives incorporating mono or dipeptide moiety

C. Supuran, A. Angeli, G. Bartolucci, 2020, Journal of enzyme inhibition and medicinal chemistry.

Activation studies of the β-carbonic anhydrases from Malassezia restricta with amines and amino acids

C. Supuran, C. Capasso, A. Angeli, 2020, Journal of enzyme inhibition and medicinal chemistry.

Activation Studies of the γ-Carbonic Anhydrases from the Antarctic Marine Bacteria Pseudoalteromonas haloplanktis and Colwellia psychrerythraea with Amino Acids and Amines

C. Supuran, C. Capasso, Z. Alothman, 2019, Marine drugs.

Inhibition of α-, β-, γ-, δ-, ζ- and η-class carbonic anhydrases from bacteria, fungi, algae, diatoms and protozoans with famotidine

C. Supuran, C. Capasso, M. Pinteala, 2019, Journal of enzyme inhibition and medicinal chemistry.

Anion Inhibition Profile of the β-Carbonic Anhydrase from the Opportunist Pathogenic Fungus Malassezia restricta Involved in Dandruff and Seborrheic Dermatitis

C. Supuran, C. Capasso, A. Angeli, 2019, Metabolites.

Synthesis and biological evaluation of sulfonamide‐based compounds as inhibitors of carbonic anhydrase from Vibrio cholerae

C. Supuran, V. De Luca, C. Capasso, 2022, Archiv der Pharmazie.

Diversely substituted sulfamides for fragment-based drug discovery of carbonic anhydrase inhibitors: synthesis and inhibitory profile

C. Supuran, M. Ferraroni, A. Angeli, 2022, Journal of enzyme inhibition and medicinal chemistry.

Selenides bearing benzenesulfonamide show potent inhibition activity against carbonic anhydrases from pathogenic bacteria Vibrio cholerae and Burkholderia pseudomallei.

C. Supuran, C. Capasso, G. Abbas, 2018, Bioorganic chemistry.

Design, synthesis and human carbonic anhydrase I, II, IX and XII inhibitory properties of 1,3-thiazole sulfonamides.

C. Supuran, A. Angeli, C. Altug, 2022, Bioorganic & medicinal chemistry letters.

Benzylaminoethylureido‐Tailed Benzenesulfonamides Show Potent Inhibitory Activity against Bacterial Carbonic Anhydrases

U. Farooq, C. Supuran, C. Capasso, 2020, ChemMedChem.

Carbonic anhydrase inhibitors based on sorafenib scaffold: Design, synthesis, crystallographic investigation and effects on primary breast cancer cells.

Abdul-Malek S. Al-Tamimi, C. Supuran, M. Ferraroni, 2019, European journal of medicinal chemistry.

Design, synthesis and biological evaluation of N-(5-methyl-isoxazol-3-yl/1,3,4-thiadiazol-2-yl)-4-(3-substitutedphenylureido) benzenesulfonamides as human carbonic anhydrase isoenzymes I, II, VII and XII inhibitors

C. B. Mishra, C. Supuran, A. Angeli, 2016, Journal of enzyme inhibition and medicinal chemistry.

Heterocyclic periphery in the design of carbonic anhydrase inhibitors: 1,2,4-Oxadiazol-5-yl benzenesulfonamides as potent and selective inhibitors of cytosolic hCA II and membrane-bound hCA IX isoforms.

C. Supuran, T. Tuccinardi, A. Angeli, 2018, Bioorganic chemistry.

Heterocoumarins Are Selective Carbonic Anhydrase IX and XII Inhibitors with Cytotoxic Effects against Cancer Cells Lines.

C. Supuran, C. Ghelardini, A. Angeli, 2018, ACS medicinal chemistry letters.

Ureidosulfocoumarin Derivatives As Selective and Potent Carbonic Anhydrase IX and XII Inhibitors

C. Supuran, A. Angeli, Priti Singh, 2021 .

Discovery of first-in-class multi-target adenosine A2A receptor antagonists-carbonic anhydrase IX and XII inhibitors. 8-Amino-6-aryl-2-phenyl-1,2,4-triazolo [4,3-a]pyrazin-3-one derivatives as new potential antitumor agents.

C. Supuran, G. Marucci, M. Buccioni, 2020, European journal of medicinal chemistry.

Design, synthesis, SAR, and biological evaluation of saccharin‐based hybrids as carbonic anhydrase inhibitors

C. Supuran, A. Angeli, S. Nanduri, 2022, Archiv der Pharmazie.

Synthesis and exploration of 2-morpholino-4-phenylthiazol-5-yl acrylamide derivatives for their effects against carbonic anhydrase I, II, IX and XII isoforms as a non-sulfonamide class of inhibitors.

C. Supuran, A. Angeli, Priti Singh, 2019, Bioorganic & medicinal chemistry.

Tail-approach based design and synthesis of Arylthiazolylhydrazono-1,2,3-triazoles incorporating sulfanilamide and metanilamide as human carbonic anhydrase I, II, IV and IX inhibitors.

C. Supuran, Arunandan Kumar, A. Angeli, 2022, Bioorganic chemistry.

Synthesis and carbonic anhydrase inhibition of polycyclic imides incorporating N-benzenesulfonamide moieties.

C. Supuran, A. Angeli, A. Nocentini, 2017, Bioorganic & medicinal chemistry.

Unconventional amino acids in medicinal chemistry: First report on taurine merged within carbonic anhydrase inhibitors.

C. Supuran, D. Vullo, A. Angeli, 2020, Bioorganic chemistry.

3-Functionalised Benzenesulphonamide based 1,3,4-oxadiazoles as Selective Carbonic Anhydrase XIII Inhibitors: Design, Synthesis and Biological Evaluation.

Abhay, C. Supuran, A. Angeli, 2021, Bioorganic & medicinal chemistry letters.

Novel thiazolidinone-containing compounds, without the well-known sulphonamide zinc-binding group acting as human carbonic anhydrase IX inhibitors

C. Supuran, A. Angeli, Özlen Güzel-Akdemir, 2018, Journal of enzyme inhibition and medicinal chemistry.

Chalcogenides-incorporating carbonic anhydrase inhibitors concomitantly reverted oxaliplatin-induced neuropathy and enhanced antiproliferative action.

S. Carradori, C. Supuran, M. Ferraroni, 2021, European journal of medicinal chemistry.

Anticancer effects of new dibenzenesulfonamides by inducing apoptosis and autophagy pathways and their carbonic anhydrase inhibitory effects on hCA I, hCA II, hCA IX, hCA XII isoenzymes.

C. Supuran, C. Yamali, A. Angeli, 2018, Bioorganic chemistry.

Dual Carbonic Anhydrase IX/XII Inhibitors and Carbon Monoxide Releasing Molecules Modulate LPS-Mediated Inflammation in Mouse Macrophages

S. Carradori, C. Supuran, H. Schweikl, 2021, Antioxidants.

Novel benzenesulfonamides aryl and arylsulfone conjugates adopting tail/dual tail approaches: Synthesis, carbonic anhydrase inhibitory activity and molecular modeling studies.

C. Supuran, A. Angeli, H. Abdel‐Aziz, 2021, European journal of medicinal chemistry.

Synthesis and biological evaluation of coumarin‐thiazole hybrids as selective carbonic anhydrase IX and XII inhibitors

C. Supuran, A. Angeli, N. S. Goud, 2022, Archiv der Pharmazie.

Structural Basis of Nanomolar Inhibition of Tumor-Associated Carbonic Anhydrase IX: X-Ray Crystallographic and Inhibition Study of Lipophilic Inhibitors with Acetazolamide Backbone.

C. Supuran, M. Ilies, A. Angeli, 2020, Journal of medicinal chemistry.

Unprotected primary sulfonamide group facilitates ring-forming cascade en route to polycyclic [1,4]oxazepine-based carbonic anhydrase inhibitors.

C. Supuran, A. Angeli, S. Kalinin, 2018, Bioorganic chemistry.

Mechanisms of the Antiproliferative and Antitumor Activity of Novel Telomerase-Carbonic Anhydrase Dual-Hybrid Inhibitors.

C. Supuran, M. Ferraroni, A. Veselovsky, 2021, Journal of medicinal chemistry.

Cloning, characterization, and inhibition of the novel β-carbonic anhydrase from parasitic blood fluke, Schistosoma mansoni

C. Supuran, A. Angeli, S. Parkkila, 2023, Journal of enzyme inhibition and medicinal chemistry.

A novel small molecule that kills a subset of MLL-rearranged leukemia cells by inducing mitochondrial dysfunction

A. Osterman, C. Supuran, R. Pearson, 2019, Oncogene.

Terminators or Guardians? Design, Synthesis, and Cytotoxicity Profiling of Chalcone-Sulfonamide Hybrids

C. Supuran, A. Angeli, Haytham O. Tawfik, 2023, ACS omega.

Measuring the effect of Mankai® (Wolffia globosa) on the gut microbiota and its metabolic output using an in vitro colon model

F. Fava, K. Tuohy, A. Angeli, 2021 .

From random to rational: A discovery approach to selective subnanomolar inhibitors of human carbonic anhydrase IV based on the Castagnoli-Cushman multicomponent reaction.

C. Supuran, V. Sharoyko, T. Tennikova, 2019, European journal of medicinal chemistry.

Lucky Switcheroo: Dramatic Potency and Selectivity Improvement of Imidazoline Inhibitors of Human Carbonic Anhydrase VII.

C. Supuran, T. Tuccinardi, A. Angeli, 2017, ACS medicinal chemistry letters.

Structure‐guided identification of a selective sulfonamide‐based inhibitor targeting the human carbonic anhydrase VA isoform

C. Supuran, A. Angeli, R. Gitto, 2022, Archiv der Pharmazie.

N-aryl-N'-ureido-O-sulfamates as potent and selective inhibitors of hCA VB over hCA VA: Deciphering the binding mode of new potential agents in mitochondrial dysfunctions.

C. Supuran, T. Tuccinardi, A. Angeli, 2020, Bioorganic chemistry.

Novel sulfonamide-containing 2-indolinones that selectively inhibit tumor-associated alpha carbonic anhydrases.

C. Supuran, A. Angeli, N. Karalı, 2017, Bioorganic & medicinal chemistry.

Discovery of new 2, 5-disubstituted 1,3-selenazoles as selective human carbonic anhydrase IX inhibitors with potent anti-tumor activity.

C. Supuran, M. Ferraroni, C. Ghelardini, 2018, European journal of medicinal chemistry.

Five-Membered Heterocyclic Sulfonamides as Carbonic Anhydrase Inhibitors

C. Supuran, A. Angeli, Niccolò Paoletti, 2023, Molecules.

Carbonic Anhydrases: Versatile and Useful Biocatalysts in Chemistry and Biochemistry

C. Supuran, A. Angeli, F. Carta, 2020, Catalysts.

Developing an in vitro elicitation strategy for specialized secondary metabolites production in adventitious root cultures of Primula veris subsp. veris

A. Angeli, E. Sarrou, S. Martens, 2023, Industrial Crops and Products.

Selenols: a new class of carbonic anhydrase inhibitors.

C. Supuran, M. Ferraroni, A. Angeli, 2019, Chemical communications.

Sultam based Carbonic Anhydrase VII inhibitors for the management of neuropathic pain.

C. Supuran, C. Ghelardini, K. D'Ambrosio, 2021, European journal of medicinal chemistry.

Polypharmacology of Epacadostat: a Potent and Selective Inhibitor of the Tumor Associated Carbonic Anhydrases IX and XII

C. Supuran, M. Ferraroni, A. Angeli, 2019 .

Synthesis and anti-inflammatory activity of sulfonamides and carboxylates incorporating trimellitimides: Dual cyclooxygenase/carbonic anhydrase inhibitory actions.

C. Supuran, A. Angeli, A. Abdel-Aziz, 2019, Bioorganic chemistry.

Tail approach synthesis of triazolylthiazolotriazole bearing benzenesulfonamides as carbonic anhydrase inhibitors capable of inducing apoptosis

C. Supuran, A. Angeli, Lalit Vats, 2022, Archiv der Pharmazie.

Selenocarbamates As a Prodrug‐Based Approach to Carbonic Anhydrase Inhibition

C. Supuran, M. Ferraroni, A. Angeli, 2022, ChemMedChem.

Novel ureidosulfocoumarin derivatives as selective and potent carbonic anhydrase IX and XII inhibitors: Design, synthesis and biological evaluation.

C. Supuran, A. Angeli, Priti Singh, 2021, ChemMedChem.

Selenium-analogs based on natural sources as cancer-associated carbonic anhydrase isoforms IX and XII inhibitors

C. Supuran, A. Angeli, P. Gratteri, 2023, Journal of enzyme inhibition and medicinal chemistry.

Measuring phenolic compounds in Mankai: a novel polyphenol and amino rich plant protein source

K. Tuohy, A. Angeli, M. Gobbetti, 2020, Proceedings of the Nutrition Society.

Further validation of strecker-type α-aminonitriles as a new class of potent human carbonic anhydrase II inhibitors: hit expansion within the public domain using differential scanning fluorimetry leads to chemotype refinement

C. Supuran, A. Angeli, S. Zozulya, 2019, Journal of enzyme inhibition and medicinal chemistry.

Evaluation of Thio- and Seleno-Acetamides Bearing Benzenesulfonamide as Inhibitor of Carbonic Anhydrases from Different Pathogenic Bacteria

C. Supuran, C. Capasso, G. Abbas, 2020, International journal of molecular sciences.

Multiplexed cellular profiling identifies an organoselenium compound as an inhibitor of CRM1‐mediated nuclear export

C. Supuran, R. Silvestri, W. Link, 2022, Traffic.

Substituted furan sulfonamides as carbonic anhydrase inhibitors: Synthesis, biological and in silico studies.

C. Supuran, A. Angeli, A. Geronikaki, 2023, Bioorganic chemistry.

Famotidine, an Antiulcer Agent, Strongly Inhibits Helicobacter pylori and Human Carbonic Anhydrases.

C. Supuran, M. Ferraroni, A. Angeli, 2018, ACS medicinal chemistry letters.

Intramolecular oxidative deselenization of acylselenoureas: a facile synthesis of benzoxazole amides and carbonic anhydrase inhibitors.

C. Supuran, T. Peat, A. Angeli, 2016, Organic & biomolecular chemistry.

Fibrate-based N-acylsulphonamides targeting carbonic anhydrases: synthesis, biochemical evaluation, and docking studies

S. Carradori, C. Supuran, A. Angeli, 2019, Journal of enzyme inhibition and medicinal chemistry.

Discovery of sulfonamide-tethered isatin derivatives as novel anticancer agents and VEGFR-2 inhibitors

C. Supuran, A. Angeli, Wagdy M. Eldehna, 2023, Journal of enzyme inhibition and medicinal chemistry.

Photoactivatable Heptamethine-Based Carbonic Anhydrase Inhibitors Leading to New Anti-Antibacterial Agents

S. Carradori, C. Supuran, C. Capasso, 2023, International journal of molecular sciences.

An efficient method for the synthesis of novel derivatives 4-{5-[4-(4-amino-5-mercapto-4H-[1,2,4]triazol-3-yl)-phenyl]-3-trifluoromethyl-pyrazol-1-yl}-benzenesulfonamide and their anti-inflammatory potential.

C. Supuran, A. Angeli, M. Zia-ur-Rehman, 2019, Bioorganic chemistry.

Synthesis, Biological and In Silico Studies of Griseofulvin and Usnic Acid Sulfonamide Derivatives as Fungal, Bacterial and Human Carbonic Anhydrase Inhibitors

C. Supuran, C. Capasso, A. Angeli, 2023, International journal of molecular sciences.

Multitargeting application of proline-derived peptidomimetics addressing cancer-related human matrix metalloproteinase 9 and carbonic anhydrase II.

C. Supuran, A. Angeli, F. Carta, 2021, European journal of medicinal chemistry.

Design, Synthesis, and X-ray of Selenides as New Class of Agents for Prevention of Diabetic Cerebrovascular Pathology.

C. Supuran, T. Peat, C. Ghelardini, 2018, ACS medicinal chemistry letters.

Crystal structure and chemical inhibition of essential schistosome host-interactive virulence factor carbonic anhydrase SmCA

C. Supuran, M. Ferraroni, A. Angeli, 2019, Communications Biology.

Selenolesterase enzyme activity of carbonic anhydrases.

C. Supuran, M. Ferraroni, A. Angeli, 2020, Chemical communications.

Discovery of a new potent oxindole multi-kinase inhibitor among a series of designed 3-alkenyl-oxindoles with ancillary carbonic anhydrase inhibitory activity as antiproliferative agents

C. Supuran, A. Angeli, Nagwa M. Abdel Gawad, 2023, BMC Chemistry.

Handling drug-target selectivity: A study on ureido containing Carbonic Anhydrase inhibitors.

C. Supuran, A. Angeli, F. Carta, 2020, European journal of medicinal chemistry.

Catechols: a new class of carbonic anhydrase inhibitors.

S. Carradori, C. Supuran, K. D'Ambrosio, 2020, Chemical communications.

Selenols: a new class of Carbonic Anhydrase inhibitors

C. Supuran, M. Ferraroni, A. Angeli, 2018 .

Benzenesulfonamide derivatives as Vibrio cholerae carbonic anhydrases inhibitors: a computational-aided insight in the structural rigidity-activity relationships

S. Carradori, C. Supuran, C. Capasso, 2023, Journal of enzyme inhibition and medicinal chemistry.

Treatment of sleep apnea with a combination of a carbonic anhydrase inhibitor and an aldosterone antagonist: a patent evaluation of CA2958110 and IN6616DEN2012

C. Supuran, A. Angeli, 2018, Expert opinion on therapeutic patents.

Nature as a source and inspiration for human monoamine oxidase B (hMAO-B) inhibition: A review of the recent advances in chemical modification of natural compounds

S. Carradori, A. Angeli, Francesco Melfi, 2023, Expert opinion on drug discovery.

New Insights into Conformationally Restricted Carbonic Anhydrase Inhibitors

C. Supuran, A. Angeli, F. Carta, 2023, Molecules.

Synthesis of new 7‐amino‐3,4‐dihydroquinolin‐2(1H)‐one‐peptide derivatives and their carbonic anhydrase enzyme inhibition, antioxidant, and cytotoxic activities

C. Supuran, Ö. Yeşilada, A. Angeli, 2021, Archiv der Pharmazie.

Synthesis, computational studies and assessment of in vitro inhibitory activity of umbelliferon-based compounds against tumour-associated carbonic anhydrase isoforms IX and XII

C. Supuran, C. Capasso, A. Angeli, 2020, Journal of enzyme inhibition and medicinal chemistry.

Novel Carbonic Anhydrase Inhibitors with Dual-Tail Core Sulfonamide Show Potent and Lasting Effects for Glaucoma Therapy.

C. Supuran, M. Ferraroni, C. Capasso, 2024, Journal of medicinal chemistry.

Mono- and three-tailed sugar and iminosugar decorated benzenesulfonamide carbonic anhydrase inhibitors.

C. Supuran, M. Ferraroni, A. Angeli, 2023, Organic & biomolecular chemistry.