D. Basile

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Flipped classroom model improves graduate student performance in cardiovascular, respiratory, and renal physiology.

Michael Sturek, M. Sturek, J. Tune, 2013, Advances in physiology education.

Renal ischemic injury results in permanent damage to peritubular capillaries and influences long-term function.

D. Basile, J. Osborn, D. Donohoe, 2001, American journal of physiology. Renal physiology.

Rarefaction of peritubular capillaries following ischemic acute renal failure: a potential factor predisposing to progressive nephropathy

D. Basile, 2004, Current opinion in nephrology and hypertension.

The transforming growth factor beta system in kidney disease and repair: recent progress and future directions.

D. Basile, David P. Basile, 1999, Current opinion in nephrology and hypertension.

Basic fibroblast growth factor receptor in the rat adrenal cortex: effects of suramin and unilateral adrenalectomy on receptor numbers.

D. Basile, M. A. Holzwarth, 1994, Endocrinology.

A method to facilitate and monitor expression of exogenous genes in the rat kidney using plasmid and viral vectors.

V. Gattone, R. Bacallao, S. Atkinson, 2013, American journal of physiology. Renal physiology.

Resistance to ischemic acute renal failure in the Brown Norway rat: a new model to study cytoprotection.

Xia Cao, D. Basile, D. Donohoe, 2004, Kidney international.

Pathogenesis of Acute Kidney Injury

R. Basu, D. Basile, S. V. Van Why, 2021, Pediatric Nephrology.

VEGF-121 preserves renal microvessel structure and ameliorates secondary renal disease following acute kidney injury.

D. Basile, Ellen C. Leonard, Jessica L. Friedrich, 2008, American journal of physiology. Renal physiology.

Renal ischemia reperfusion inhibits VEGF expression and induces ADAMTS-1, a novel VEGF inhibitor.

D. Basile, B. Chelladurai, K. Fredrich, 2008, American journal of physiology. Renal physiology.

Impaired endothelial proliferation and mesenchymal transition contribute to vascular rarefaction following acute kidney injury.

B. Molitoris, R. Bacallao, D. Basile, 2011, American journal of physiology. Renal physiology.

Activated pericytes and the inhibition of renal vascular stability: obstacles for kidney repair.

D. Basile, T. A. Sutton, T. Sutton, 2012, Journal of the American Society of Nephrology : JASN.

Progression after AKI: Understanding Maladaptive Repair Processes to Predict and Identify Therapeutic Treatments.

J. Kellum, C. Ronco, M. Nangaku, 2016, Journal of the American Society of Nephrology : JASN.

Identification of persistently altered gene expression in the kidney after functional recovery from ischemic acute renal failure.

Mingyu Liang, D. Basile, C. Vio, 2005, American journal of physiology. Renal physiology.

Th17 cells contribute to pulmonary fibrosis and inflammation during chronic kidney disease progression after acute ischemia.

S. Gunst, D. Basile, P. Mehrotra, 2018, American journal of physiology. Regulatory, integrative and comparative physiology.

Pathogenesis of Acute Kidney Injury

D. Basile, R. Sreedharan, S. Why, 2019, Kidney Protection.

Transforming growth factor-beta in acute renal failure: receptor expression, effects on proliferation, cellularity, and vascularization after recovery from injury.

D. Basile, K. Spurgeon, D. Donohoe, 2005, American journal of physiology. Renal physiology.

The endothelial cell in ischemic acute kidney injury: implications for acute and chronic function.

D. Basile, 2007, Kidney international.

Recovery from acute renal failure predisposes hypertension and secondary renal disease in response to elevated sodium.

D. Basile, D. Mattson, D. Donohoe, 2007, American journal of physiology. Renal physiology.

The case for capillary rarefaction in the AKI to CKD progression: insights from multiple injury models.

D. Basile, 2019, American journal of physiology. Renal physiology.

Role of Renal Hypoxia in the Progression From Acute Kidney Injury to Chronic Kidney Disease.

D. Basile, M. Ullah, 2019, Seminars in nephrology.

Endothelial colony-forming cells ameliorate endothelial dysfunction via secreted factors following ischemia-reperfusion injury.

M. Yoder, D. Basile, W. Shelley, 2017, American journal of physiology. Renal physiology.

TGF-β in Renal Development and Renal Growth

D. Basile, M. Hammerman, 1998, Mineral and Electrolyte Metabolism.

Transforming growth factor-β as a target for treatment in diabetic nephropathy

D. Basile, 2001 .

Serum IL-17 levels are higher in critically ill patients with AKI and associated with worse outcomes

Javier A. Neyra, J. Neyra, R. Toto, 2022, Critical Care.

An expanding role of Toll-like receptors in sepsis-induced acute kidney injury.

D. Basile, P. Dagher, 2008, American journal of physiology. Renal physiology.

Renal endothelial dysfunction in acute kidney ischemia reperfusion injury.

M. Yoder, D. Basile, 2014, Cardiovascular & hematological disorders drug targets.

Chromosome substitution modulates resistance to ischemia reperfusion injury in Brown Norway rats

M. Dwinell, Shur-Jen Wang, B. Shames, 2012, Kidney international.

IL-17 mediates neutrophil infiltration and renal fibrosis following recovery from ischemia reperfusion: compensatory role of natural killer cells in athymic rats.

D. Basile, P. Mehrotra, J. Collett, 2017, American journal of physiology. Renal physiology.

Regeneration and replacement of endothelial cells and renal vascular repair

M. Yoder, D. Basile, 2022 .

Increased ANG II sensitivity following recovery from acute kidney injury: role of oxidant stress in skeletal muscle resistance arteries.

D. Basile, S. Phillips, K. R. Pechman, 2010, American journal of physiology. Regulatory, integrative and comparative physiology.

Angiostatin and matrix metalloprotease expression following ischemic acute renal failure.

D. Weihrauch, D. Basile, W. Chilian, 2004, American journal of physiology. Renal physiology.

The human plasminogen activator inhibitor type I gene promoter targets to kidney.

C. Sorenson, D. Basile, M. Hammerman, 1998, American journal of physiology. Renal physiology.

Recovery from renal ischemia-reperfusion injury is associated with altered renal hemodynamics, blunted pressure natriuresis, and sodium-sensitive hypertension.

D. Basile, D. Mattson, K. R. Pechman, 2009, American journal of physiology. Regulatory, integrative and comparative physiology.

Chronic renal hypoxia after acute ischemic injury: effects of L-arginine on hypoxia and secondary damage.

D. Basile, D. Mattson, D. Donohoe, 2003, American journal of physiology. Renal physiology.

Getting the "inside" scoop on ephrinB2 signaling in pericytes and the effect on peritubular capillary stability.

M. Yoder, D. Basile, 2013, Journal of the American Society of Nephrology : JASN.

Kidney injury risk during prolonged exposure to current and projected wet bulb temperatures occurring during extreme heat events in healthy young men.

Riana R Pryor, Riana R. Pryor, Blair D. Johnson, 2022, Journal of applied physiology.

Angiostatin Does Not Contribute to Skeletal Muscle Microvascular Rarefaction with Low Nitric Oxide Bioavailability

D. Basile, J. Samora, J. Frisbee, 2007, Microcirculation.

Increased transforming growth factor-beta 1 expression in regenerating rat renal tubules following ischemic injury.

D. Basile, D. Martin, M. Hammerman, 1996, The American journal of physiology.

Extracellular matrix-related genes in kidney after ischemic injury: potential role for TGF-beta in repair.

D. Basile, D. Martin, M. Hammerman, 1998, The American journal of physiology.

elevated sodium hypertension and secondary renal disease in response to Recovery from acute renal failure predisposes

D. Basile, D. Mattson, D. Donohoe, 2016 .

Immune suppression blocks sodium-sensitive hypertension following recovery from ischemic acute renal failure.

D. Basile, D. Mattson, K. R. Pechman, 2008, American journal of physiology. Regulatory, integrative and comparative physiology.

Low Proliferative Potential and Impaired Angiogenesis of Cultured Rat Kidney Endothelial Cells

M. Yoder, D. Basile, Ellen C. Leonard, 2012, Microcirculation.

Toward an effective gene therapy in renal disease.

D. Basile, 1999, Kidney international.

Origin, Prospective Identification, and Function of Circulating Endothelial Colony Forming Cells in Mouse and Human

R. Adams, X. Xuei, M. Yoder, 2022, bioRxiv.

Vitamin D deficiency contributes to vascular damage in sustained ischemic acute kidney injury

R. Volpini, D. Basile, L. Andrade, 2016, Physiological reports.

Challenges of targeting vascular stability in acute kidney injury.

D. Basile, 2008, Kidney international.

Mutation of RORγT reveals a role for Th17 cells in both injury and recovery from renal ischemia reperfusion injury.

M. Dwinell, D. Basile, A. Geurts, 2020, American journal of physiology. Renal physiology.

Distinct effects on long-term function of injured and contralateral kidneys following unilateral renal ischemia-reperfusion.

D. Basile, S. Goenka, Ellen C. Leonard, 2012, American journal of physiology. Renal physiology.

Specific Lowering of Asymmetric Dimethylarginine by Pharmacological Dimethylarginine Dimethylaminohydrolase Improves Endothelial Function, Reduces Blood Pressure and Ischemia-Reperfusion Injury

A. Shekhar, D. Basile, J. Sasser, 2020, The Journal of Pharmacology and Experimental Therapeutics.

Specific Lowering of ADMA by Pharmacological DDAH Improves Endothelial Function, Reduces Blood Pressure and Ischemia-Reperfusion Injury.

A. Shekhar, D. Basile, J. Sasser, 2020, The Journal of pharmacology and experimental therapeutics.

Microsoft Word-DDAH-1 JPET- Fast Forward.docx

Jaipal, A. Shekhar, D. Basile, 2020 .

Persistent oxidative stress following renal ischemia-reperfusion injury increases ANG II hemodynamic and fibrotic activity.

D. Basile, Ellen C. Leonard, Jessica L. Friedrich, 2012, American journal of physiology. Renal physiology.

Effect of renal shock wave lithotripsy on the development of metabolic syndrome in a juvenile swine model: a pilot study.

J. Lingeman, A. Evan, B. Connors, 2015, The Journal of urology.

Pathophysiology of acute kidney injury.

D. Basile, T. A. Sutton, Timothy A Sutton, 2012, Comprehensive Physiology.

Sodium reabsorption in the thick ascending limb in relation to blood pressure: a clinical perspective.

D. Basile, J. Pratt, Jeesun Jung, 2011, Hypertension.

Pressure : A Clinical Perspective Sodium Reabsorption in the Thick Ascending Limb in Relation to Blood

D. Basile, J. Pratt, Jeesun Jung, 2011 .

Circulating and Tissue Resident Endothelial Progenitor Cells

M. Yoder, D. Basile, 2013, Journal of cellular physiology.

Crystals or His(stones): Rethinking AKI in Tumor Lysis Syndrome.

D. Basile, 2022, Journal of the American Society of Nephrology : JASN.

Extracellular matrix-related genes in kidney after ischemic injury: potential role for TGF-β in repair.

D. Basile, M. Hammerman, Daniel R. Martin, 1998, American journal of physiology. Renal physiology.

Basic fibroblast growth factor may mediate proliferation in the compensatory adrenal growth response.

D. Basile, M. A. Holzwarth, 1993, The American journal of physiology.

Macrophage dynamics in kidney repair: elucidation of a COX-2-dependent MafB pathway to affect macrophage differentiation.

D. Basile, 2022, Kidney international.

Human adipose stromal cell therapy improves survival and reduces renal inflammation and capillary rarefaction in acute kidney injury

K. March, D. Basile, Stephanie Merfeld‐Clauss, 2017, Journal of cellular and molecular medicine.

Transcriptome analysis and kidney research: toward systems biology.

J. Lazar, M. Hessner, Mingyu Liang, 2005, Kidney international.

Expression of the RNA-stabilizing protein HuR in ischemia-reperfusion injury of rat kidney.

Beth S. Lee, D. Basile, Mamata Singh, 2009, American journal of physiology. Renal physiology.

Soluble thrombomodulin reduces inflammation and prevents microalbuminuria induced by chronic endothelial activation in transgenic mice.

G. Sandusky, M. Clauss, D. Basile, 2012, American journal of physiology. Renal physiology.

Contribution of Th17 cells to tissue injury in hypertension

D. Basile, D. Mattson, Justine M. Abais-Battad, 2020, Current opinion in nephrology and hypertension.

Leptin regulates gallbladder genes related to absorption and secretion.

H. Pitt, D. Basile, A. Mathur, 2007, American journal of physiology. Gastrointestinal and liver physiology.

Vasodilatation in the rat dorsal hindpaw induced by activation of sensory neurons is reduced by paclitaxel.

M. Kelley, D. Basile, M. Vasko, 2011, Neurotoxicology.

Novel approaches in the investigation of acute kidney injury.

D. Basile, 2007, Journal of the American Society of Nephrology : JASN.

Enhanced skeletal muscle arteriolar reactivity to ANG II after recovery from ischemic acute renal failure.

D. Basile, S. Phillips, D. Donohoe, 2005, American journal of physiology. Regulatory, integrative and comparative physiology.

Exogenous Gene Transmission of Isocitrate Dehydrogenase 2 Mimics Ischemic Preconditioning Protection.

B. Molitoris, R. Bacallao, F. Witzmann, 2018, Journal of the American Society of Nephrology : JASN.

Hydrodynamic Isotonic Fluid Delivery Ameliorates Moderate-to-Severe Ischemia-Reperfusion Injury in Rat Kidneys.

B. Molitoris, R. Bacallao, Caroline A. Miller, 2017, Journal of the American Society of Nephrology : JASN.

Hydrodynamic delivery of mitochondrial genes in vivo protects against moderate ischemia‐reperfusion injury in the rat kidney (690.17)

R. Bacallao, F. Witzmann, S. Atkinson, 2014 .

AKI: a path forward.

P. Kimmel, B. Molitoris, T. Nickolas, 2013, American Society of Nephrology. Clinical Journal.

Expression of bcl-2 and bax in regenerating rat renal tubules following ischemic injury.

H. Liapis, D. Basile, M. Hammerman, 1997, The American journal of physiology.

Involvement of the ubiquitin pathway in decreasing Ku70 levels in response to drug-induced apoptosis.

A. Haas, L. Mayo, D. Basile, 2006, Experimental cell research.

Endothelial colony‐forming cells and pro‐angiogenic cells: clarifying definitions and their potential role in mitigating acute kidney injury

M. Yoder, D. Basile, J. Collett, 2018, Acta physiologica.

Th-17 cell activation in response to high salt following acute kidney injury is associated with progressive fibrosis and attenuated by AT-1R antagonism

D. Basile, P. Mehrotra, C. Ivancic, 2015, Kidney international.

T helper 17 cells in the pathophysiology of acute and chronic kidney disease

D. Basile, M. Ullah, P. Mehrotra, 2021, Kidney research and clinical practice.

A GAP in our knowledge of vascular signaling in acute kidney injury.

D. Basile, 2011, Kidney international.

A Therapeutic Extracorporeal Device for Specific Removal of Pathologic Asymmetric Dimethylarginine from the Blood

D. Basile, Jaipal Singh, S. Steinbach, 2022, Blood Purification.

Unique Gene Expression in Developing Ascending Vasa Recta: A Tale of Tie.

M. Yoder, D. Basile, 2018, Journal of the American Society of Nephrology : JASN.

The Renal Lymph Node and Immune Tolerance to Filtered Antigens

M. Yoder, D. Basile, 2013 .

Enhanced skeletal muscle arteriolar reactivity to angiotensin II after recovery from ischemic acute renal failure

D. Basile, S. Phillips, D. Donohoe, 2005 .

Orai1: A New Therapeutic Target for the Acute Kidney Injury-to-Chronic Kidney Disease Transition

D. Basile, J. Collett, 2021, Nephron.

Calcium channel Orai1 promotes lymphocyte IL17 expression and progressive kidney injury.

Javier A. Neyra, J. Neyra, M. Sturek, 2019, The Journal of clinical investigation.

Surprising Enhancement of Fibrosis by Tubule-Specific Deletion of the TGF-β Receptor: A New Twist on an Old Paradigm.

D. Basile, P. Mehrotra, 2017, Journal of the American Society of Nephrology : JASN.

Calcium channel Orai1 promotes lymphocyte IL-17 expression and progressive kidney injury.

Javier A. Neyra, J. Neyra, M. Sturek, 2020, The Journal of clinical investigation.

Hydrodynamic Isotonic Fluid Delivery Ameliorates Moderate-to-Severe Ischemia-Reperfusion Injury in Rat Kidneys.

B. Molitoris, R. Bacallao, Caroline A. Miller, 2017, Journal of the American Society of Nephrology : JASN.

Persistent oxidative stress following renal ischemia-reperfusion injury increases ANG II hemodynamic and fibrotic activity.

D. Basile, Ellen C. Leonard, Jessica L. Friedrich, 2012, American journal of physiology. Renal physiology.

AKI: a path forward.

P. Kimmel, B. Molitoris, T. Nickolas, 2013, Clinical journal of the American Society of Nephrology : CJASN.

curriculumof students from a conventional medical problem-solving tutorials toward better learning: Combination of didactic lectures and case-oriented

M. Sturek, J. Tune, D. Basile, 2015 .

Flipped classroom model improves graduate student performance in cardiovascular, respiratory, and renal physiology.

M. Sturek, J. Tune, D. Basile, 2013, Advances in physiology education.

Specific Lowering of Asymmetric Dimethylarginine by Pharmacological Dimethylarginine Dimethylaminohydrolase Improves Endothelial Function, Reduces Blood Pressure and Ischemia-Reperfusion Injury s

A. Shekhar, D. Basile, J. Sasser, 2021 .