J. Lepock

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Cellular effects of hyperthermia: relevance to the minimum dose for thermal damage

J. Lepock, James R Lepock, 2003, International journal of hyperthermia : the official journal of European Society for Hyperthermic Oncology, North American Hyperthermia Group.

Sonication of proteins causes formation of aggregates that resemble amyloid

J. Rumfeldt, P. Stathopulos, E. Meiering, 2004, Protein science : a publication of the Protein Society.

Minimal model for studying prion‐like folding pathways

A. Lemak, J. Lepock, Jeff Z. Y. Chen, 2003, Proteins.

Differential effects of senescence on the molecular organization of membranes in ripening tomato fruit.

J. Thompson, J. Lepock, R. Legge, 1986, Plant physiology.

The effects of cotyledon senescence on the composition and physical properties of membrane lipid.

J. Thompson, J. Lepock, J. Kruuv, 1978, Biochimica et biophysica acta.

The Role of a Conserved Water Molecule in the Redox-dependent Thermal Stability of Iso-1-cytochrome c *

A. Berghuis, J. Lepock, J. G. Guillemette, 1996, The Journal of Biological Chemistry.

PROTEIN DENATURATION: ITS ROLE IN THERMAL KILLING

J. Lepock, 1992 .

The nuclear matrix is a thermolabile cellular structure

R. Warters, J. Lepock, G. Senisterra, 2001, Cell stress & chaperones.

Radioprotective Thiolamines WR-1065 and WR-33278 Selectively Denature Nonhistone Nuclear Proteins

R. Warters, B. H. Wilmore, J. Lepock, 2000, Radiation research.

Proteins containing non‐native disulfide bonds generated by oxidative stress can act as signals for the induction of the heat shock response

J. Morrow, M. Freeman, M. Borrelli, 1997, Journal of cellular physiology.

Effects of 4-h ischemia and 1-h reperfusion on rat muscle sarcoplasmic reticulum function.

N. McKee, J. Lepock, G. Senisterra, 2001, American journal of physiology. Endocrinology and metabolism.

Effects of ischemia on sarcoplasmic reticulum Ca(2+) uptake and Ca(2+) release in rat skeletal muscle.

N. McKee, J. Lepock, G. Senisterra, 2001, American journal of physiology. Endocrinology and metabolism.

Thermal activation of the bovine Hsc70 molecular chaperone at physiological temperatures: physical evidence of a molecular thermometer.

L. Hightower, S. Sadis, J. Lepock, 1996, Cell stress & chaperones.

Human mitochondrial manganese superoxide dismutase polymorphic variant Ile58Thr reduces activity by destabilizing the tetrameric interface.

M. Boissinot, G. Borgstahl, J. Tainer, 1996, Biochemistry.

Novel dimeric interface and electrostatic recognition in bacterial Cu,Zn superoxide dismutase.

J. Tainer, E. Getzoff, J. Lepock, 1996, Proceedings of the National Academy of Sciences of the United States of America.

Function of the Greek key connection analysed using circular permutants of superoxide dismutase

M. Boissinot, J. Tainer, E. Getzoff, 1997, The EMBO journal.

Thermal analysis of bacteria by differential scanning calorimetry: relationship of protein denaturation in situ to maximum growth temperature.

W. E. Inniss, J. Lepock, H. Frey, 1990, Biochimica et biophysica acta.

Factors influencing survival of mammalian cells exposed to hypothermia. IV. Effects of iron chelation.

J. Lepock, J. Kruuv, M. Zieger, 1990, Cryobiology.

Factors influencing survival of mammalian cells exposed to hypothermia. V. Effects of hepes, free radicals, and H2O2 under light and dark conditions.

J. Lepock, J. Kruuv, M. Zieger, 1991, Cryobiology.

Structural analyses of various Cu2+, Zn2+-superoxide dismutases by differential scanning calorimetry and Raman spectroscopy.

J. Lepock, J. Kruuv, L. Arnold, 1985, Archives of biochemistry and biophysics.

Rotational diffusion of TEMPONE in the cytoplasm of Chinese hamster lung cells.

J. Lepock, J. Kruuv, K. Cheng, 1983, Biophysical journal.

Amino Acid Substitution at the Dimeric Interface of Human Manganese Superoxide Dismutase*

J. Tainer, D. Silverman, H. Nick, 2004, Journal of Biological Chemistry.

Changes in crystallographic structure and thermostability of a Cu,Zn superoxide dismutase mutant resulting from the removal of a buried cysteine.

J. Tainer, E. Getzoff, D. McRee, 1993, The Journal of biological chemistry.

Protection of the membrane calcium adenosine triphosphatase by cholesterol from thermal inactivation.

S. Hui, J. Lepock, K. Cheng, 1987, Cancer research.

Effect of the organic Ca2+ channel blocker D-600 on sarcoplasmic reticulum Ca2+ uptake in skeletal muscle.

J. Lepock, A. Ortega, H. Gonzalez-serratos, 1997, The American journal of physiology.

Dismutase Superoxide Interface of Human Manganese Amino Acid Substitution at the Dimeric Enzyme Catalysis and Regulation

J. Tainer, D. Silverman, H. Nick, 2014 .

Cycloheximide increases the thermostability of proteins in Chinese hamster ovary cells.

Y. Lee, M. Borrelli, J. Lepock, 1991, Biochemical and biophysical research communications.

Amino acid pools in CHL V79 cells during induction of thermotolerance: Reduction in free intracellular glutamine

E. B. Dumbroff, J. Lepock, C. Goh, 1988, Journal of cellular physiology.

Use of spin labels and electron spin resonance spectroscopy to characterize membranes of bovine sperm: effect of butylated hydroxytoluene and cold shock.

R. Hammerstedt, A. Keith, J. Lepock, 1976, Biology of reproduction.

Spin labels for cell surfaces

R. Hammerstedt, A. Keith, J. Lepock, 1975, FEBS letters.

The role of cholesterol in the activity of reconstituted Ca-ATPase vesicles containing unsaturated phosphatidylethanolamine.

S. Hui, P. Yeagle, J. Lepock, 1986, The Journal of biological chemistry.

Hyperthermia (heat shock)-induced protein denaturation in liver, muscle and lens tissue as determined by differential scanning calorimetry.

B. M. Keller, J. Lepock, K. Ritchie, 1994, International journal of hyperthermia : the official journal of European Society for Hyperthermic Oncology, North American Hyperthermia Group.

Interaction of superoxide dismutase with phospholipid liposomes. An uptake, spin label and calorimetric study.

J. Lepock, L. Arnold, A. Petkau, 1981, Biochimica et biophysica acta.

Effect of membrane lipid perturbers on the temperature dependence of repair of sublethal and potentially lethal radiation damage.

J. Thompson, J. Lepock, J. Kruuv, 1981, International journal of radiation biology and related studies in physics, chemistry, and medicine.

Spin label studies of microsomal membranes from Acanthamoeba castellanii in different states of differentiation.

J. Thompson, J. Lepock, K. P. Pauls, 1980, Archives of biochemistry and biophysics.

Effect of salt solutions on the radiosensitivity of mammalian cells as a function of the state of adhesion and the water structure.

J. Lepock, J. Kruuv, P. G. Moggach, 1979, International journal of radiation biology and related studies in physics, chemistry, and medicine.

Factors influencing survival and growth of mammalian cells exposed to hypothermia. I. Effects of temperature and membrane lipid perturbers

J. Lepock, J. Kruuv, K. Cheng, 1983, Journal of cellular physiology.

Reversibility of the thermal denaturation of yeast superoxide dismutase

J. Lepock, L. Arnold, 1982, FEBS letters.

Damage due to ultraviolet and ionizing radiation during the ejection of shielded micro-organisms from the vicinity of 1M⊙ main sequence and red giant stars

J. Secker, J. Lepock, P. Wesson, 1994 .

Protein degradation in CHL V79 cells during and after exposure to 43 degrees C.

J. Lepock, J. Kruuv, M. Heynen, 1989, Radiation research.

Sensitization of rat hepatocytes to hyperthermia by calcium

J. Lepock, A. Malhotra, J. Kruuv, 1986, Journal of cellular physiology.

CALORIMETRIC ANALYSIS OF THERMODYNAMIC STABILITY AND AGGREGATION FOR APO AND HOLO ALS-ASSOCIATED GLY93 MUTANTS OF SUPEROXIDE DISMUTASE 1

J. Rumfeldt, P. Stathopulos, E. Meiering, 2005 .

Role of hydrogen bonding in the active site of human manganese superoxide dismutase.

J. Tainer, D. Silverman, J. Perry, 2004, Biochemistry.

Interrupting the Hydrogen Bond Network at the Active Site of Human Manganese Superoxide Dismutase*

J. Tainer, D. Silverman, Y. Guan, 1999, The Journal of Biological Chemistry.

Factors influencing survival of mammalian cells exposed to hypothermia. II. Effects of various hypertonic media.

J. Lepock, J. Kruuv, D. Glofcheski, 1985, Cryobiology.

The effect of fluidity of membrane lipids on freeze-thaw survival of yeast.

A. Keith, J. Lepock, J. Kruuv, 1978, Cryobiology.

How do cells respond to their thermal environment?

J. Lepock, 2005, International journal of hyperthermia : the official journal of European Society for Hyperthermic Oncology, North American Hyperthermia Group.

Freeze-thaw damage in isolated lobster sarcoplasmic reticulum membranes: a model system for membrane damage.

A. Keith, J. Lepock, J. Kruuv, 1978, Cryobiology.

The effect of membrane lipid perturbers on survival of mammalian cells to cold.

J. Thompson, J. Frim, J. Lepock, 1978, Cryobiology.

Effects of butylated hydroxytoluene on membrane lipid fluidity and freeze-thaw survival in mammalian cells.

J. Lepock, J. Kruuv, S. D. Campbell, 1986, Cryobiology.

Analysis of all protein amino acids as their tert.-butyldimethylsilyl derivatives by gas-liquid chromatography.

E. B. Dumbroff, J. Lepock, K. Craven, 1987, Analytical biochemistry.

Equilibrium thermodynamic analysis of amyotrophic lateral sclerosis-associated mutant apo Cu,Zn superoxide dismutases.

J. Rumfeldt, P. Stathopulos, Kenrick A. Vassall, 2006, Biochemistry.

Calorimetric Analysis of Thermodynamic Stability and Aggregation for Apo and Holo Amyotrophic Lateral Sclerosis-associated Gly-93 Mutants of Superoxide Dismutase*

J. Rumfeldt, P. Stathopulos, E. Meiering, 2006, Journal of Biological Chemistry.

Contribution of conformational stability and reversibility of unfolding to the increased thermostability of human and bovine superoxide dismutase mutated at free cysteines.

J. Lepock, R. Hallewell, H. Frey, 1990, The Journal of biological chemistry.

Mechanism of freeze-thaw damage to liver alcohol dehydrogenase and protection by cryoprotectants and amino acids.

J. Lepock, J. Kruuv, D. Glofcheski, 1990, Cryobiology.

Ischemia-induced structural change in SR Ca2+-ATPase is associated with reduced enzyme activity in rat muscle.

N. McKee, J. Lepock, G. Senisterra, 2001, American journal of physiology. Regulatory, integrative and comparative physiology.

HSP70 Binds to the Fast-twitch Skeletal Muscle Sarco(endo)plasmic Reticulum Ca2+-ATPase (SERCA1a) and Prevents Thermal Inactivation*

A. Gramolini, M. Hori, K. Otsu, 2004, Journal of Biological Chemistry.

Simultaneous Two-photon Excitation of Photofrin in Relation to Photodynamic Therapy

Mamta Khurana, Aliaksandr Karotki, Brian C Wilson, 2006, Photochemistry and photobiology.

Protein denaturation in intact hepatocytes and isolated cellular organelles during heat shock

J. Lepock, J R Lepock, H E Frey, 1993, The Journal of cell biology.

Recombinant lysine:N(6)-hydroxylase: effect of cysteine-->alanine replacements on structural integrity and catalytic competence.

J. Lepock, S. Siemann, T. Viswanatha, 2002, Biochimica et biophysica acta.

Unfolding and folding kinetics of amyotrophic lateral sclerosis-associated mutant Cu,Zn superoxide dismutases.

Elizabeth M Meiering, J. Rumfeldt, E. Meiering, 2009, Journal of molecular biology.

Mechanism and thermodynamics of guanidinium chloride-induced denaturation of ALS-associated mutant Cu,Zn superoxide dismutases.

J. Rumfeldt, P. Stathopulos, E. Meiering, 2006, Journal of molecular biology.

Monomeric Cu,Zn-superoxide Dismutase Is a Common Misfolding Intermediate in the Oxidation Models of Sporadic and Familial Amyotrophic Lateral Sclerosis*[boxs]

A. Chakrabartty, J. Lepock, N. Cashman, 2004, Journal of Biological Chemistry.

Lack of a correlation between hyperthermic cell killing, thermotolerance, and membrane lipid fluidity.

J. Lepock, J. Kruuv, G. Rule, 1981, Radiation research.

Characterization and radiation response of a heat-resistant variant of V79 cells.

J. Lepock, J. Kruuv, S. D. Campbell, 1983, Radiation research.

Protective effect of L-glutamine against freeze-thaw damage in mammalian cells.

J. Lepock, J. Kruuv, D. Glofcheski, 1988, Cryobiology.

Involvement of membranes in cellular responses to hyperthermia.

J. Lepock, J R Lepock, 1982, Radiation research.

Relationship of hyperthermia-induced hemolysis of human erythrocytes to the thermal denaturation of membrane proteins.

J. Lepock, J R Lepock, H E Frey, 1989, Biochimica et biophysica acta.

Thermal denaturation of the Ca2(+)-ATPase of sarcoplasmic reticulum reveals two thermodynamically independent domains.

J. Lepock, J R Lepock, A M Rodahl, 1990, Biochemistry.

Thermal destabilization of transmembrane proteins by local anaesthetics

J. Lepock, G. Senisterra, J R Lepock, 2000, International journal of hyperthermia : the official journal of European Society for Hyperthermic Oncology, North American Hyperthermia Group.

Novel chemical enhancers of heat shock increase thermal radiosensitization through a mitotic catastrophe pathway.

R. Bristow, P. Crooks, N. Horikoshi, 2007, Cancer research.

Differential polarized phase fluorometric studies of the perturbation of phospholipid packing by BHT.

J. Lepock, K. Cheng, 1985, Chemistry and physics of lipids.

Protein Denaturation During Heat Shock

J. Lepock, 1997 .

Destabilization and denaturation of cellular protein by glutathione depletion.

M. Freeman, J. Lepock, G. Senisterra, 1997, Cell stress & chaperones.

On the path to the heat shock response: destabilization and formation of partially folded protein intermediates, a consequence of protein thiol modification.

M. Freeman, M. Borrelli, J. Lepock, 1999, Free radical biology & medicine.

Diamide‐induced cytotoxicity and thermotolerance in CHO cells

M. Borrelli, L. J. Bernock, J. Lepock, 1998, Journal of cellular physiology.

Role of nuclear protein denaturation and aggregation in thermal radiosensitization

J. Lepock, J. R. Lepock, James R. Lepock, 2004, International journal of hyperthermia : the official journal of European Society for Hyperthermic Oncology, North American Hyperthermia Group.

Thermotolerance as a Possible Cause of the Critical Temperature at 43 in Mammalian Cells1

J. Lepock, J. Kruuv, 2006 .

Thermotropic lipid and protein transitions in chinese hamster lung cell membranes: relationship to hyperthermic cell killing.

J. Lepock, J. Kruuv, K. Cheng, 1983, Canadian journal of biochemistry and cell biology = Revue canadienne de biochimie et biologie cellulaire.

Multiphoton ANS fluorescence microscopy as an in vivo sensor for protein misfolding stress

S. Croul, A. Guha, J. McLaurin, 2011, Cell Stress and Chaperones.

Role of extracellular calcium in the hyperthermic killing of CHL V79 cells.

J. Lepock, A. Malhotra, M. Heynen, 1987, Radiation research.

Evidence for two modes of hypothermia damage in five cell lines.

J. Lepock, J. Kruuv, D. Glofcheski, 1995, Cryobiology.

Interaction of D-600 with the transmembrane domain of the sarcoplasmic reticulum Ca(2+)-ATPase.

J. Lepock, A. Ortega, R. Álvarez, 2000, American journal of physiology. Cell physiology.

Calorimetric characterization of critical targets for killing and acquired thermotolerance in yeast

H. Iwahashi, J. Lepock, Y. Komatsu, 2000, Yeast.

Interaction of dibucaine with the transmembrane domain of the Ca(2+)-ATPase of sarcoplasmic reticulum.

C. Anteneodo, E. Meiering, J. Lepock, 1994, Biochemistry.

Influence of transition rates and scan rate on kinetic simulations of differential scanning calorimetry profiles of reversible and irreversible protein denaturation.

J. Lepock, J. Kruuv, M. Kolios, 1992, Biochemistry.

Measurement of protein stability and protein denaturation in cells using differential scanning calorimetry.

J. Lepock, 2005, Methods.

Stabilization of two families of critical targets for hyperthermic cell killing and acquired thermotolerance of yeast cells

H. Iwahashi, J. Lepock, Y. Komatsu, 1998, Yeast.

Increased thermostability of thermotolerant CHL V79 cells as determined by differential scanning calorimetry

J. Lepock, J. Nishio, J. Kruuv, 1990, Journal of cellular physiology.

Inactivation of calcium uptake by EGTA is due to an irreversible thermotropic conformational change in the calcium binding domain of the Ca(2+)-ATPase.

J. Lepock, K. Cheng, 1992, Biochemistry.

Multiple replacements of glutamine 143 in human manganese superoxide dismutase: effects on structure, stability, and catalysis.

J. Tainer, D. Silverman, M. Stroupe, 2000, Biochemistry.

Computer Simulations of Mechanical Micromanipulation of Proteins

J. Lepock, Jeff Z. Y. Chen, A. S. Lemak, 2004 .

Molecular dynamics simulations of a protein model in uniform and elongational flows

J. Lepock, Jeff Z. Y. Chen, A. S. Lemak, 2003, Proteins.

Photoinduced cell killing and crosslinking of fluorescein conjugated concanavalin A to cell surface proteins.

M. Gruber, J. Lepock, J. Kruuv, 1979, Biochemical and biophysical research communications.

Cu/Zn superoxide dismutase mutants associated with amyotrophic lateral sclerosis show enhanced formation of aggregates in vitro

J. Rumfeldt, P. Stathopulos, E. Meiering, 2003, Proceedings of the National Academy of Sciences of the United States of America.

Hyperthermia-induced inhibition of respiration and mitochondrial protein denaturation in CHL cells.

C. Koch, J. Lepock, J. Kruuv, 1987, International journal of hyperthermia : the official journal of European Society for Hyperthermic Oncology, North American Hyperthermia Group.

Destabilization of the Ca2+-ATPase of sarcoplasmic reticulum by thiol-specific, heat shock inducers results in thermal denaturation at 37 degrees C.

M. Escaravage, M. Freeman, M. Borrelli, 1997, Biochemistry.

Characterization of a signal generated by oxidation of protein thiols that activates the heat shock transcription factor

M. Borrelli, J. Lepock, G. Senisterra, 1995, Journal of cellular physiology.

In vivo resolution of oligomers with fluorescence photobleaching recovery histograms

M. Borrelli, J. Lepock, E. Jervis, 2006, Cell stress & chaperones.

Photoinduced crosslinking of membrane proteins by fluorescein isothiocyanate.

J. Thompson, J. Lepock, J. Kruuv, 1978, Biochemical and biophysical research communications.

Cholesterol increases the thermal stability of the Ca2+/Mg(2+)-ATPase of cardiac microsomes.

J. Mas-Oliva, J. Lepock, J. Santiago-García, 1996, Biochimica et biophysica acta.

Membrane lipid fluidity as rate limiting in the concanavalin A-mediated agglutination of pyBHK cells.

J. Lepock, J. Kruuv, G. Rule, 1979, Biochimica et biophysica acta.