D. Villareal

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Aerobic Plus Resistance Exercise in Obese Older Adults Improves Muscle Protein Synthesis and Preserves Myocellular Quality Despite Weight Loss.

K. Yarasheski, N. Putluri, C. Qualls, 2019, Cell metabolism.

Effective SLOPE: EffectS of Lifestyle interventions in Older PEople with obesity: a systematic review and network meta-analysis protocol

D. Volkert, G. Rücker, D. Schoene, 2020, BMJ Open.

A 2-Year Randomized Controlled Trial of Human Caloric Restriction: Feasibility and Effects on Predictors of Health Span and Longevity.

Corby K. Martin, W. Kraus, E. Ravussin, 2015, The journals of gerontology. Series A, Biological sciences and medical sciences.

Cognitive and Neural Correlates of Aerobic Fitness in Obese Older Adults

Denise Head, Krupa Shah, D. Head, 2012, Experimental aging research.

2 years of calorie restriction and cardiometabolic risk (CALERIE): exploratory outcomes of a multicentre, phase 2, randomised controlled trial.

W. Kraus, E. Ravussin, L. Redman, 2019, The lancet. Diabetes & endocrinology.

IL-1-induced murine osteoblast IL-6 production is mediated by the type 1 IL-1 receptor and is increased by 1,25 dihydroxyvitamin D3.

D. Lacey, D. Villareal, R. Pacifici, 1993, The Journal of clinical investigation.

Dehydroepiandrosterone replacement therapy in older adults: 1- and 2-y effects on bone.

J. Holloszy, E. Weiss, C. Lambert, 2009, The American journal of clinical nutrition.

Effects of Exercise Training Added to Ongoing Hormone Replacement Therapy on Bone Mineral Density in Frail Elderly Women

K. Yarasheski, W. Kohrt, D. Sinacore, 2003, Journal of the American Geriatrics Society.

Effect of Aerobic or Resistance Exercise, or Both, on Intermuscular and Visceral Fat and Physical and Metabolic Function in Older Adults with Obesity While Dieting.

C. Qualls, D. Sinacore, L. Aguirre, 2021, The journals of gerontology. Series A, Biological sciences and medical sciences.

Effects of Dehydroepiandrosterone on Bone Mineral Density

D. Villareal, 2002 .

Exercise but not diet-induced weight loss decreases skeletal muscle inflammatory gene expression in frail obese elderly persons.

C. Lambert, D. Villareal, B. Finck, 2008, Journal of applied physiology.

Long-term maintenance of weight loss after lifestyle intervention in frail, obese older adults

C. Qualls, R. Armamento-Villareal, D. Villareal, 2012, The journal of nutrition, health & aging.

Effect of CYP1A1 Gene Polymorphisms on Estrogen Metabolism and Bone Density

S. Mumm, N. Napoli, R. Armamento-Villareal, 2004, Journal of bone and mineral research : the official journal of the American Society for Bone and Mineral Research.

Bone mineral density response to caloric restriction-induced weight loss or exercise-induced weight loss: a randomized controlled trial.

K. Schechtman, S. Klein, S. Racette, 2006, Archives of internal medicine.

Exercise training in obese older adults prevents increase in bone turnover and attenuates decrease in hip bone mineral density induced by weight loss despite decline in bone‐active hormones

C. Qualls, D. Sinacore, N. Napoli, 2011, Journal of bone and mineral research : the official journal of the American Society for Bone and Mineral Research.

Weight loss in obese older adults increases serum sclerostin and impairs hip geometry but both are prevented by exercise training

C. Qualls, D. Sinacore, N. Napoli, 2012, Journal of bone and mineral research : the official journal of the American Society for Bone and Mineral Research.

Calorie restriction in humans inhibits the PI3K/AKT pathway and induces a younger transcription profile

E. Mercken, Dudley Lamming, D. Sabatini, 2013, Aging cell.

Effect of Aerobic or Resistance Exercise, or Both, on Bone Mineral Density and Bone Metabolism in Obese Older Adults While Dieting: A Randomized Controlled Trial

C. Qualls, N. Napoli, L. Aguirre, 2019, Journal of bone and mineral research : the official journal of the American Society for Bone and Mineral Research.

Weight Loss-Induced Reduction of Bone Mineral Density in Older Adults with Obesity

D. Villareal, Bryan C Jiang, Bryan C. Jiang, 2019, Journal of nutrition in gerontology and geriatrics.

Regular Multicomponent Exercise Increases Physical Fitness and Muscle Protein Anabolism in Frail, Obese, Older Adults

D. Sinacore, D. Villareal, B. Mittendorfer, 2011, Obesity.

Endothelial function after high-sugar-food ingestion improves with endurance exercise performed on the previous day.

J. Holloszy, E. Weiss, D. Villareal, 2008, The American journal of clinical nutrition.

The FTO gene is associated with a paradoxically favorable cardiometabolic risk profile in frail, obese older adults

C. Qualls, N. Napoli, G. Colleluori, 2016, Pharmacogenetics and genomics.

Sex‐specific effects of dehydroepiandrosterone (DHEA) on bone mineral density and body composition: A pooled analysis of four clinical trials

K. Nair, M. Jensen, S. Khosla, 2018, Clinical endocrinology.

Dehydroepiandrosterone (DHEA) replacement decreases insulin resistance and lowers inflammatory cytokines in aging humans

J. Holloszy, E. Weiss, D. Villareal, 2011, Aging.

Effect of DHEA on abdominal fat and insulin action in elderly women and men: a randomized controlled trial.

J. Holloszy, D. Villareal, 2004, JAMA.

Effects of DHEA replacement on bone mineral density and body composition in elderly women and men

W. Kohrt, J. Holloszy, D. Villareal, 2000, Clinical endocrinology.

Definition and Diagnostic Criteria for Sarcopenic Obesity: ESPEN and EASO Consensus Statement

D. Volkert, S. Heymsfield, L. Donini, 2022, Obesity Facts.

Association between high-sensitivity troponin T and cardiovascular risk in individuals with and without metabolic syndrome: The ARIC study

J. Pankow, E. Boerwinkle, S. Solomon, 2017, European journal of preventive cardiology.

Truncal Fat and Frailty Are Important Predictors of Cognitive Performance among Aging Adults with Obesity

M. Kunik, D. Villareal, H. D. Heisey, 2022, The journal of nutrition, health & aging.

DHEA enhances effects of weight training on muscle mass and strength in elderly women and men.

J. Holloszy, D. Villareal, 2006, American journal of physiology. Endocrinology and metabolism.

Bone Mineral Density Response to Estrogen Replacement in Frail Elderly Women

K. Yarasheski, K. Schechtman, W. Kohrt, 2013 .

Bone mineral density response to estrogen replacement in frail elderly women: a randomized controlled trial.

K. Yarasheski, D. B. Williams, K. Schechtman, 2001, JAMA.

Absence of left ventricular and arterial adaptations to exercise in octogenarians.

A. Ehsani, R. Spina, D. Villareal, 2004, Journal of applied physiology.

Effects of 2‐year calorie restriction on circulating levels of IGF‐1, IGF‐binding proteins and cortisol in nonobese men and women: a randomized clinical trial

E. Ravussin, S. Klein, S. Meydani, 2015, Aging cell.

Safety of two-year caloric restriction in non-obese healthy individuals

W. Kraus, E. Ravussin, L. Redman, 2016, Oncotarget.

Weight loss in obese adults 65years and older: A review of the controversy

Aimee L. Ward, D. Villareal, D. Waters, 2013, Experimental Gerontology.

Fat Mass Follows a U-Shaped Distribution Based on Estradiol Levels in Postmenopausal Women

C. Qualls, N. Napoli, G. Colleluori, 2018, Front. Endocrinol..

Weight loss and improved fitness slow down the decline in mobility in obese adults with type 2 diabetes

D. Villareal, K. Shah, 2012, Evidence-Based Medicine.

CHAPTER 83 – Obesity

D. Villareal, K. Shah, 2010 .

Effect of weight loss and exercise therapy on bone metabolism and mass in obese older adults: a one-year randomized controlled trial.

S. Klein, D. Sinacore, D. Villareal, 2008, The Journal of clinical endocrinology and metabolism.

Subclinical vitamin D deficiency in postmenopausal women with low vertebral bone mass.

L. Avioli, R. Civitelli, A. Chines, 1991, The Journal of clinical endocrinology and metabolism.

Vitamin K and Bone Health in Older Adults

D. Villareal, K. Shah, L. Gleason, 2014, Journal of nutrition in gerontology and geriatrics.

One-Year Mean A1c of > 7% is Associated with Poor Bone Microarchitecture and Strength in Men with Type 2 Diabetes Mellitus

G. Colleluori, R. Armamento-Villareal, D. Villareal, 2022, Calcified Tissue International.

Increasing adiposity is associated with higher adipokine levels and lower bone mineral density in obese older adults.

C. Qualls, N. Napoli, L. Aguirre, 2014, The Journal of clinical endocrinology and metabolism.

Fat, Muscle, and Bone Interactions in Obesity and the Metabolic Syndrome

N. Napoli, R. Armamento-Villareal, D. Villareal, 2014, International journal of endocrinology.

Editorial Fat, Muscle, and Bone Interactions in Obesity and the Metabolic Syndrome

M. Debakey, N. Napoli, R. Armamento-Villareal, 2014 .

Effect of estrogen and calcitonin on vertebral bone density and vertebral height in osteoporotic women

L. Avioli, R. Civitelli, D. Villareal, 1992, Osteoporosis International.

Estrogen status and heredity are major determinants of premenopausal bone mass.

L. Avioli, R. Civitelli, R. Armamento-Villareal, 1992, The Journal of clinical investigation.

Effects of soy protein isolate and moderate exercise on bone turnover and bone mineral density in postmenopausal women

E. Evans, S. Racette, R. V. Van Pelt, 2007, Menopause.

Effects of exercise training on bone mineral density in frail older women and men: a randomised controlled trial.

K. Yarasheski, K. Schechtman, M. Brown, 2004, Age and ageing.

Diet and Exercise Interventions Reduce Intrahepatic Fat Content and Improve Insulin Sensitivity in Obese Older Adults

S. Klein, D. Sinacore, D. Villareal, 2009, Obesity.

Long‐term effects of calorie or protein restriction on serum IGF‐1 and IGFBP‐3 concentration in humans

S. Klein, J. Holloszy, E. Weiss, 2008, Aging cell.

Xenin-25 Amplifies GIP-Mediated Insulin Secretion in Humans With Normal and Impaired Glucose Tolerance but Not Type 2 Diabetes

K. Polonsky, M. Wallendorf, D. Reeds, 2012, Diabetes.

Testosterone and Adipokines are Determinants of Physical Performance, Strength, and Aerobic Fitness in Frail, Obese, Older Adults

L. Aguirre, Kenneth Fowler, R. Armamento-Villareal, 2014, International journal of endocrinology.

obese elderly persons skeletal muscle inflammatory gene expression in frail Exercise but not diet-induced weight loss decreases

B. Pedersen, C. Schéele, D. Cameron-Smith, 2010 .

Xenin-25 Ampli fi es GIP-Mediated Insulin Secretion in Humans With Normal and Impaired Glucose Tolerance but Not Type 2 Diabetes

K. Polonsky, M. Wallendorf, D. Reeds, 2012 .

Testosterone Replacement Therapy added to Intensive Lifestyle Intervention in Older Men with Obesity and Hypogonadism.

Vijay Nambi, M. Marcelli, C. Qualls, 2020, The Journal of clinical endocrinology and metabolism.

Muscle protein synthesis response to exercise training in obese, older men and women.

D. Sinacore, D. Villareal, B. Mittendorfer, 2012, Medicine and science in sports and exercise.

Effect of Weight Loss on the Rate of Muscle Protein Synthesis During Fasted and Fed Conditions in Obese Older Adults

D. Villareal, B. Mittendorfer, K. Shah, 2012, Obesity.

during basal, postabsorptive conditions measured muscle protein fractional synthesis rate Timing of the initial muscle biopsy does not affect the

D. Reeds, C. Lambert, D. Villareal, 2010 .

Timing of the initial muscle biopsy does not affect the measured muscle protein fractional synthesis rate during basal, postabsorptive conditions.

D. Reeds, B. S. Mohammed, C. Lambert, 2010, Journal of applied physiology.

Differences in Muscle Protein Synthesis and Anabolic Signaling in the Postabsorptive State and in Response to Food in 65–80 Year Old Men and Women

M. Rennie, D. Villareal, B. Mittendorfer, 2008, PloS one.

Measurement of human mixed muscle protein fractional synthesis rate depends on the choice of amino acid tracer.

D. Villareal, B. Mittendorfer, Gordon I. Smith, 2007, American journal of physiology. Endocrinology and metabolism.

High aromatase activity in hypogonadal men is associated with higher spine bone mineral density, increased truncal fat and reduced lean mass.

C. Qualls, G. Colleluori, L. Aguirre, 2015, European journal of endocrinology.

Long-term effects of caloric restriction or exercise on DNA and RNA oxidation levels in white blood cells and urine in humans.

S. Anton, T. Hofer, E. Weiss, 2008, Rejuvenation research.

Long-Term Calorie Restric tion Enhances Cellular Quality-Control Processes in HumanSkeletalMuscle Graphical

N. Veronese, G. Hotamisligil, J. Holloszy, 2016 .

Long-Term Calorie Restriction Enhances Cellular Quality-Control Processes in Human Skeletal Muscle.

N. Veronese, G. Hotamisligil, J. Holloszy, 2016, Cell reports.

Low bone mass in subjects on a long-term raw vegetarian diet.

J. Holloszy, D. Villareal, L. Fontana, 2005, Archives of internal medicine.

Association of triglyceride-glucose index and lung health: a population-based study.

M. McCormack, I. Rosas, N. Hanania, 2021, Chest.

Designing Drug Trials for Frailty: ICFSR Task Force 2018

S. Kritchevsky, M. Pahor, J. Morley, 2018, The Journal of Frailty & Aging.

Effect of weight loss and exercise on frailty in obese older adults.

S. Klein, D. Sinacore, D. Villareal, 2006, Archives of internal medicine.

Outcomes addressed in randomized controlled lifestyle intervention trials in community‐dwelling older people with (sarcopenic) obesity—An evidence map

D. Volkert, M. Visser, D. Schoene, 2022, Obesity reviews : an official journal of the International Association for the Study of Obesity.

Effect of Weight Loss, Exercise, or Both on Undercarboxylated Osteocalcin and Insulin Secretion in Frail, Obese Older Adults

N. Napoli, G. Colleluori, Uma Phadnis, 2017, Oxidative medicine and cellular longevity.

Sarcopenic obesity: how do we treat it?

D. Villareal, M. Bouchonville, 2013, Current opinion in endocrinology, diabetes, and obesity.

Weight loss, exercise, or both and physical function in obese older adults.

Clifford Qualls, Nicola Napoli, David R Sinacore, 2011, The New England journal of medicine.

Effect of Diet, Exercise, or Both on Biological Age and Healthy Aging in Older Adults with Obesity: Secondary Analysis of a Randomized Controlled Trial

D. Villareal, E. Ho, C. Qualls, 2022, The journal of nutrition, health & aging.

WEIGHT‐LOSS THERAPY IMPROVES ENDURANCE CAPACITY IN OBESE OLDER ADULTS

C. Lambert, D. Villareal, K. Shah, 2008, Journal of the American Geriatrics Society.

Baseline Testosterone Predicts Body Composition and Metabolic Response to Testosterone Therapy

G. Colleluori, L. Aguirre, R. Armamento-Villareal, 2022, Frontiers in Endocrinology.

Comparison of Methods for Assessing Abdominal Adipose Tissue from Magnetic Resonance Images

S. Racette, J. Holloszy, E. Weiss, 2007, Obesity.

Testosterone Therapy Effects on Bone Mass and Turnover in Hypogonadal Men with Type 2 Diabetes.

C. Qualls, N. Napoli, G. Colleluori, 2021, The Journal of clinical endocrinology and metabolism.

Bone and body composition response to testosterone therapy vary according to polymorphisms in the CYP19A1 gene

C. Qualls, G. Colleluori, L. Aguirre, 2019, Endocrine.

Hypogonadal men with type 2 diabetes mellitus have smaller bone size and lower bone turnover.

C. Qualls, G. Colleluori, L. Aguirre, 2017, Bone.

Is there an effective treatment for glucocorticoid-induced osteoporosis?

L. Avioli, R. Civitelli, D. Villareal, 1991, Calcified Tissue International.

Effect of lifestyle intervention on the hormonal profile of frail, obese older men

C. Qualls, L. Aguirre, R. Armamento-Villareal, 2016, The journal of nutrition, health & aging.

Two Years of Calorie Restriction and Cardiometabolic Risk Factors

W. Kraus, L. Redman, C. Pieper, 2019 .

Attenuation of cardiovascular adaptations to exercise in frail octogenarians.

J. Holloszy, A. Ehsani, R. Spina, 2003, Journal of applied physiology.

Trophic Factors in Aging

J. Morley, D. Villareal, 1994 .

Circulating osteogenic progenitors and osteoclast precursors are associated with long-term glycemic control, sex steroids, and visceral adipose tissue in men with type 2 diabetes mellitus

S. Bathina, R. Armamento-Villareal, D. Villareal, 2022, Frontiers in Endocrinology.

Weight strategy in older adults with obesity: calorie restriction or not?

G. Colleluori, D. Villareal, 2022, Current opinion in clinical nutrition and metabolic care.

Effects of dehydroepiandrosterone on bone mineral density: what implications for therapy?

D. Villareal, 2002, Treatments in endocrinology.

Aerobic plus Resistance Exercise in Obese Older Adults Improves Muscle Protein Synthesis and Preserves Myocellular Quality Despite Calorie Restriction

K. Yarasheski, Qualls, N. Putluri, 2019 .

Exercise attenuates the weight-loss-induced reduction in muscle mass in frail obese older adults.

D. Sinacore, D. Villareal, T. N. Frimel, 2008, Medicine and science in sports and exercise.

Weight Loss Therapy Improves Pancreatic Endocrine Function in Obese Older Adults

K. Polonsky, S. Klein, D. Villareal, 2008, Obesity.

Obesity in older adults: technical review and position statement of the American Society for Nutrition and NAASO, The Obesity Society.

Robert F Kushner, C. Apovian, S. Klein, 2005, Obesity research.

PREVENTING FRAILTY IN OBESE OLDER ADULTS.

D. Villareal, K. Shah, 2012, The Journal of frailty & aging.

Changes in thigh muscle volume predict bone mineral density response to lifestyle therapy in frail, obese older adults

C. Qualls, D. Sinacore, N. Napoli, 2014, Osteoporosis International.

Measurement of nitric oxide synthase and its mRNA in genetically obese (ob/ob) mice.

J. Morley, D. Villareal, V. B. Kumar, 1995, Life sciences.

Effects of prolonged calorie restriction on inflammation and immune function: a randomized controlled trial in non‐obese humans (40.4)

S. Klein, S. Meydani, J. Holloszy, 2014 .

IGF‐1, nutrition and aging: the big picture

S. Klein, J. Holloszy, E. Weiss, 2009 .

Improvements in glucose tolerance and insulin action induced by increasing energy expenditure or decreasing energy intake: a randomized controlled trial.

K. Schechtman, S. Klein, S. Racette, 2006, The American journal of clinical nutrition.

Effect of lifestyle intervention on metabolic coronary heart disease risk factors in obese older adults.

S. Klein, Bernard V. Miller, D. Sinacore, 2006, The American journal of clinical nutrition.

Estrogen for Bone Health in Frail Elderly Women—Reply

K. Yarasheski, K. Schechtman, W. Kohrt, 2001 .

Obesity in older adults: technical review and position statement of the American Society for Nutrition and NAASO, The Obesity Society.

Robert F Kushner, C. Apovian, S. Klein, 2005, The American journal of clinical nutrition.

Dietary L-lysine and calcium metabolism in humans.

L. Avioli, R. Civitelli, D. Villareal, 1992, Nutrition.

Sarcopenic obesity in older adults: aetiology, epidemiology and treatment strategies

J. Batsis, D. Villareal, 2018, Nature Reviews Endocrinology.

TCF7L2 Variant rs7903146 Affects the Risk of Type 2 Diabetes by Modulating Incretin Action

K. Polonsky, G. Bell, D. Villareal, 2009, Diabetes.

The diagnosis of Alzheimer's disease.

John X. Morris, J. Morris, D. Villareal, 1999, Journal of Alzheimer's disease : JAD.

Aging, obesity, sarcopenia and the effect of diet and exercise intervention

G. Colleluori, D. Villareal, 2021, Experimental Gerontology.

Kir6.2 Variant E23K Increases ATP-Sensitive K+ Channel Activity and Is Associated With Impaired Insulin Release and Enhanced Insulin Sensitivity in Adults With Normal Glucose Tolerance

K. Polonsky, G. Bell, C. Nichols, 2009, Diabetes.

Aromatase Inhibitors Plus Weight Loss Improves the Hormonal Profile of Obese Hypogonadal Men Without Causing Major Side Effects

C. Qualls, G. Colleluori, R. Armamento-Villareal, 2020, Frontiers in Endocrinology.

Inflammatory Osteolysis in Diabetic Neuropathic (Charcot) Arthropathies of the Foot

D. Sinacore, D. Villareal, M. Hastings, 2008, Physical Therapy.

Long-term moderate calorie restriction inhibits inflammation without impairing cell-mediated immunity: a randomized controlled trial in non-obese humans

C. Pieper, S. Klein, S. Meydani, 2016, Aging.

Hemoglobin A1c Threshold for Reduction in Bone Turnover in Men With Type 2 Diabetes Mellitus

G. Colleluori, L. Aguirre, R. Armamento-Villareal, 2021, Frontiers in Endocrinology.

Preferential reductions in intermuscular and visceral adipose tissue with exercise-induced weight loss compared with calorie restriction.

E. Weiss, D. Villareal, L. Fontana, 2012, Journal of applied physiology.

Lower extremity muscle size and strength and aerobic capacity decrease with caloric restriction but not with exercise-induced weight loss.

K. Schechtman, S. Klein, S. Racette, 2007, Journal of applied physiology.

Painful diffuse osteosclerosis after intravenous drug abuse.

W. Murphy, S. Teitelbaum, M. Whyte, 1992, The American journal of medicine.

Paget's disease of bone affecting a single vertebra: Clinical, radiologic, and histopathologic correlations

A. Chines, D. Villareal, R. Pacifici, 1992, Calcified Tissue International.

Obesity in Older Adults and Strategies for Weight Management

D. Villareal, K. Shah, 2015 .

Obesity in Older Adults – A Growing Problem

D. Villareal, K. Shah, 2009 .

In Men With Obesity, T2DM Is Associated With Poor Trabecular Microarchitecture and Bone Strength, and Low Bone Turnover.

C. Qualls, N. Napoli, G. Colleluori, 2021, The Journal of clinical endocrinology and metabolism.

Cognitive response to testosterone replacement added to intensive lifestyle intervention in older men with obesity and hypogonadism: prespecified secondary analyses of a randomized clinical trial.

C. Qualls, N. Napoli, R. Armamento-Villareal, 2021, The American journal of clinical nutrition.

Effects of Weight Loss on Lean Mass, Strength, Bone, and Aerobic Capacity

E. Weiss, D. Villareal, S. Albert, 2017, Medicine and science in sports and exercise.

exercise-induced weight loss capacity decrease with caloric restriction but not with Lower extremity muscle size and strength and aerobic

S. Blair, T. Church, C. Earnest, 2015 .

Physical Exercise as Therapy for Frailty.

L. Aguirre, D. Villareal, Dennis T Villareal, 2015, Nestle Nutrition Institute workshop series.

Sexually dimorphic patterns of nutritional intake and eating behaviors in community-dwelling older adults with normal and slow gait speed

M. Cesari, S. Wayne, S. Andrieu, 2014, The journal of nutrition, health & aging.

Body-composition changes in the Comprehensive Assessment of Long-term Effects of Reducing Intake of Energy (CALERIE)-2 study: a 2-y randomized controlled trial of calorie restriction in nonobese humans.

Corby K. Martin, W. Kraus, E. Ravussin, 2017, The American journal of clinical nutrition.

Calorie restriction or exercise: effects on coronary heart disease risk factors. A randomized, controlled trial.

S. Klein, S. Racette, J. Holloszy, 2007, American journal of physiology. Endocrinology and metabolism.

International Clinical Practice Guidelines for Sarcopenia (ICFSR): Screening, Diagnosis and Management

L. Ferrucci, L. Rodríguez-Mañas, J. Guralnik, 2018, The journal of nutrition, health & aging.

STAT1 Dissociates Adipose Tissue Inflammation From Insulin Sensitivity in Obesity

David A. Bader, Sean M. Hartig, K. Rajapakshe, 2020, Diabetes.

International Exercise Recommendations in Older Adults (ICFSR): Expert Consensus Guidelines

L. Ferrucci, L. Rodríguez-Mañas, S. Kritchevsky, 2021, The journal of nutrition, health & aging.

of Outcomes Among Healthy Adults Insulin Sensitivity Following Exercise Interventions: Systematic Review and Meta-Analysis

R. Koopman, D. Mehr, E. Evans, 2015 .

Aerobic power and insulin action improve in response to endurance exercise training in healthy 77-87 yr olds.

E. Evans, S. Racette, J. Holloszy, 2005, Journal of applied physiology.

Sarcopenia Trials in Specific Diseases: Report by the International Conference on Frailty and Sarcopenia Research Task Force.

L. Rodríguez-Mañas, J. Guralnik, S. Kritchevsky, 2016, The Journal of frailty & aging.

Effects of Two Years of Calorie Restriction on Aerobic Capacity and Muscle Strength

Corby K. Martin, W. Kraus, L. Redman, 2017, Medicine and science in sports and exercise.

Clinical outcomes of possible versus probable Alzheimer’s disease

J. Morris, J. Miller, M. Storandt, 2003, Neurology.

Dehydroepiandrosterone replacement therapy in older adults improves indices of arterial stiffness

J. Holloszy, A. Ehsani, E. Weiss, 2012, Aging cell.

Influence of Weekend Lifestyle Patterns on Body Weight

Karen Steger-May, K. Schechtman, S. Racette, 2008, Obesity.

Testosterone therapy and bone quality in men with diabetes and hypogonadism: Study design and protocol

M. Liebschner, C. Qualls, G. Colleluori, 2021, Contemporary clinical trials communications.

Effects of matched weight loss from calorie restriction, exercise, or both on cardiovascular disease risk factors: a randomized intervention trial.

D. Reeds, S. Klein, E. Weiss, 2016, The American journal of clinical nutrition.

Bone Mineral Density Response to Caloric Restriction-Induced Weight Loss or Exercise-Induced Weight Loss

K. Schechtman, S. Klein, S. Racette, 2016 .

Weight Loss, Exercise, or Both and Cardiometabolic Risk Factors in Obese Older Adults: Results of a Randomized Controlled Trial

David R. Sinacore, Clifford Qualls, Nicola Napoli, 2013, International Journal of Obesity.

The effects of caloric restriction- and exercise-induced weight loss on left ventricular diastolic function.

S. Kovacs, S. Racette, J. Holloszy, 2008, American journal of physiology. Heart and circulatory physiology.

Physical frailty and body composition in obese elderly men and women.

S. Klein, D. Sinacore, D. Villareal, 2004, Obesity research.

Definition and diagnostic criteria for sarcopenic obesity: ESPEN and EASO consensus statement.

D. Volkert, S. Heymsfield, L. Donini, 2022, Clinical nutrition.

Aerobic or Resistance Exercise, or Both, in Dieting Obese Older Adults

C. Qualls, D. Sinacore, L. Aguirre, 2017, The New England journal of medicine.

Effect of Two‐Year Caloric Restriction on Bone Metabolism and Bone Mineral Density in Non‐Obese Younger Adults: A Randomized Clinical Trial

L. Redman, C. Pieper, A. Schwartz, 2016, Journal of bone and mineral research : the official journal of the American Society for Bone and Mineral Research.

Reduced bone mineral density is not associated with significantly reduced bone quality in men and women practicing long‐term calorie restriction with adequate nutrition

M. Kleerekoper, R. Armamento-Villareal, D. Villareal, 2011, Aging cell.

Calorie Restriction and Matched Weight Loss From Exercise: Independent and Additive Effects on Glucoregulation and the Incretin System in Overweight Women and Men

D. Reeds, S. Klein, E. Weiss, 2015, Diabetes Care.

Therapeutic and lifestyle approaches to obesity in older persons

D. Villareal, Bryan C. Jiang, 2019, Current opinion in clinical nutrition and metabolic care.

One year of caloric restriction in humans: feasibility and effects on body composition and abdominal adipose tissue.

K. Schechtman, S. Klein, S. Racette, 2006, The journals of gerontology. Series A, Biological sciences and medical sciences.

Estrogen status and bone mass in the premenopausal period: Is osteoporosis a developmental disease?

R. Civitelli, R. Armamento-Villareal, D. Villareal, 1993, Journal of endocrinological investigation.

Circulating cytokines as determinants of weight loss-induced improvements in insulin sensitivity

D. Reeds, E. Weiss, D. Villareal, 2016, Endocrine.

Plasma dehydroepiandrosterone sulfate and cardiovascular disease risk in older men and women.

J. Bressler, E. Boerwinkle, I. Gorlov, 2020, The Journal of clinical endocrinology and metabolism.

Osteoporosis‐Epidemiology and Pathophysiology: A Review and Update for Physical Therapists

D. Sinacore, D. Villareal, K. Moylan, 2005 .

Lifestyle Intervention Strategy to Treat Diabetes in Older Adults: A Randomized Controlled Trial.

G. Colleluori, R. Armamento-Villareal, D. Villareal, 2022, Diabetes care.

Systemic acid load from the diet affects maximal-exercise RER.

E. Weiss, D. Villareal, L. Fontana, 2012, Medicine and science in sports and exercise.

Adipocytes ESR1 Expression, Body Fat and Response to Testosterone Therapy in Hypogonadal Men Vary According to Estradiol Levels

C. Qualls, N. Napoli, G. Colleluori, 2018, Nutrients.

Caloric restriction but not exercise-induced reductions in fat mass decrease plasma triiodothyronine concentrations: a randomized controlled trial.

S. Klein, S. Racette, E. Weiss, 2008, Rejuvenation research.

Reversible states of physical and/or cognitive dysfunction: A 9-year longitudinal study

S. Andrieu, B. Vellas, C. Qualls, 2017, The journal of nutrition, health & aging.

Hypogonadal Men with Higher Body Mass Index have Higher Bone Density and Better Bone Quality but Reduced Muscle Density

C. Qualls, G. Colleluori, L. Aguirre, 2017, Calcified Tissue International.

Effect of weight loss, exercise, or both on cognition and quality of life in obese older adults.

C. Qualls, D. Sinacore, N. Napoli, 2014, The American journal of clinical nutrition.

Trophic factors in aging. Should older people receive hormonal replacement therapy?

J. Morley, D. Villareal, 1994, Drugs & aging.

Peak exercise stroke volume: associations with cardiac structure and diastolic function.

K. Schechtman, A. Ehsani, R. Spina, 2003, Journal of applied physiology.

Effects of polymorphisms of the sex hormone-binding globulin (SHBG) gene on free estradiol and bone mineral density.

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