N. Winssinger

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Identification of Covalent Bromodomain Binders through DNA Display of Small Molecules.

Nicolas Winssinger, Alexander Adibekian, Susanne Müller, 2015, Angewandte Chemie.

DNA display of fragment pairs as a tool for the discovery of novel biologically active small molecules† †Electronic supplementary information (ESI) available. See DOI: 10.1039/c4sc01654h

J. Daguer, C. Zambaldo, S. Barluenga, 2014, Chemical science.

Profiling protein function with small molecule microarrays

P. Schultz, Jennifer L. Harris, S. Ficarro, 2002, Proceedings of the National Academy of Sciences of the United States of America.

PNA-encoded protease substrate microarrays.

Jennifer L. Harris, R. Damoiseaux, B. Geierstanger, 2004, Chemistry & biology.

Synthesis of epothilones A and B in solid and solution phase

K. Nicolaou, P. Giannakakou, D. Vourloumis, 1997, Nature.

The HSP90 binding mode of a radicicol-like E-oxime determined by docking, binding free energy estimations, and NMR 15N chemical shifts.

M. Karplus, H. Kessler, A. Taly, 2009, Biophysical chemistry.

New Selenium-Based Safety-Catch Linkers: Solid-Phase Semisynthesis of Vancomycin

R. Hughes, K. Nicolaou, N. Winssinger, 2000 .

Synthesis of pochoxime prodrugs as potent HSP90 inhibitors.

A. Rubenstein, J. Heck, S. Barluenga, 2009, Bioorganic & medicinal chemistry letters.

Inhibition of HSP90 with Pochoximes: SAR and Structure‐Based Insights

L. Neckers, S. Barluenga, N. Winssinger, 2009, Chembiochem : a European journal of chemical biology.

One‐Step Derivatization of Reducing Oligosaccharides for Rapid and Live‐Cell‐Compatible Chelation‐Assisted CuAAC Conjugation

N. Winssinger, T. Machida, Takuya Machida, 2016, Chembiochem : a European journal of chemical biology.

Divergent synthesis and identification of the cellular targets of deoxyelephantopins

A. Adibekian, D. Abegg, N. Winssinger, 2016, Nature Communications.

Synthesis of sesquiterpene-inspired derivatives designed for covalent binding and their inhibition of the NF-κB pathway.

S. Barluenga, N. Winssinger, M. Cuendet, 2014, Organic & biomolecular chemistry.

Diversity-oriented synthesis of diverse polycyclic scaffolds inspired by the logic of sesquiterpene lactones biosynthesis.

S. Barluenga, N. Winssinger, Christelle Serba, 2012, Angewandte Chemie.

A New Photolabile Linker for the Photoactivation of Carboxyl Groups

K. Nicolaou, N. Winssinger, Brian S. Safina, 2001 .

Expanding the scope of PNA-encoded libraries: divergent synthesis of libraries targeting cysteine, serine and metallo-proteases as well as tyrosine phosphatases

François Debaene, Z. Pianowski, N. Winssinger, 2007 .

Visible Light Photoredox Catalysis Using Ruthenium Complexes in Chemical Biology.

N. Winssinger, Simona Angerani, 2019, Chemistry.

Peptide nucleic acid (PNA) and its applications in chemical biology, diagnostics, and therapeutics.

N. Winssinger, J. Saarbach, Pramod M Sabale, 2019, Current opinion in chemical biology.

Development of a functionalized xenon biosensor.

P. Schultz, A. Pines, D. Wemmer, 2004, Journal of the American Chemical Society.

DNA-templated release of functional molecules with an azide-reduction-triggered immolative linker.

A. Manicardi, S. Barluenga, N. Winssinger, 2011, Chemical communications.

Enhanced SNP-sensing using DNA-templated reactions through confined hybridization of minimal substrates (CHOMS)†

N. Winssinger, Ki Tae Kim, 2020, Chemical science.

Facile access to modified and functionalized PNAs through Ugi-based solid phase oligomerization.

C. Zambaldo, N. Winssinger, J. Saarbach, 2017, Bioorganic & medicinal chemistry.

Nucleic acid encoding to program self-assembly in chemical biology.

Z. Pianowski, N. Winssinger, 2008, Chemical Society reviews.

Azidopeptide nucleic acid. An alternative strategy for solid-phase peptide nucleic acid (PNA) synthesis.

François Debaene, N. Winssinger, 2003, Organic letters.

Asymmetric synthesis of pochonin E and F, revision of their proposed structure, and their conversion to potent Hsp90 inhibitors.

M. Karplus, V. Zoete, C. Zambaldo, 2012, Chemistry.

Divergent synthesis of a pochonin library targeting HSP90 and in vivo efficacy of an identified inhibitor.

L. Neckers, S. Barluenga, N. Winssinger, 2008, Angewandte Chemie.

Metathesis Reactions in Solid-Phase Organic Synthesis

S. Barluenga, N. Winssinger, Pierre-Yves Dakas, 2010 .

Diversity-oriented synthesis of pochonins and biological evaluation against a panel of kinases.

F. Totzke, S. Barluenga, N. Winssinger, 2006, Chemistry.

The HSP90 binding mode of a radicicol-like -oxime from docking, binding free energy estimations, and NMR N chemical shifts

M. Karplus, H. Kessler, A. Taly, 2020 .

Rapid miRNA imaging in cells using fluorogenic templated Staudinger reaction between PNA-based probes.

N. Winssinger, K. Górska, 2014, Methods in molecular biology.

The Molecular Chaperone Hsp90α Is Required for Meiotic Progression of Spermatocytes beyond Pachytene in the Mouse

S. Nef, D. Picard, C. Grey, 2010, PloS one.

A novel HSP90 inhibitor with reduced hepatotoxicity synergizes with radiotherapy to induce apoptosis, abrogate clonogenic survival, and improve tumor control in models of colorectal cancer

C. Belka, K. Lauber, M. Orth, 2016, Oncotarget.

A LecA ligand identified from a galactoside-conjugate array inhibits host cell invasion by Pseudomonas aeruginosa.

A. Imberty, T. Eierhoff, W. Römer, 2014, Angewandte Chemie.

Synthesis of deoxyelephantopin analogues LAGOUTTE , Roman , SERBA , Christelle

N. Winssinger, Christelle Serba, 2021 .

Synthesis of deoxyelephantopin analogues

N. Winssinger, R. Lagoutte, Christelle Serba, 2017, The Journal of Antibiotics.

Substrate screening identifies a novel target sequence for the proteasomal activity regulated by ionizing radiation

M. Pruschy, Z. Pianowski, N. Winssinger, 2010, Proteomics.

Supernatural: Artificial Nucleobases and Backbones to Program Hybridization-Based Assemblies and Circuits.

N. Winssinger, Miguel López-Tena, Si-Kai Chen, 2022, Bioconjugate chemistry.

Assembly of PNA-tagged small molecules, peptides, and carbohydrates onto DNA templates: programming the combinatorial pairing and inter-ligand distance.

J. Daguer, S. Barluenga, N. Winssinger, 2014, Methods in molecular biology.

High Spatial Resolution Imaging of Endogenous Hydrogen Peroxide in Living Cells by Solid‐State Fluorescence

N. Winssinger, E. Lindberg, 2016, Chembiochem : a European journal of chemical biology.

Withaferin A, a polyfunctional pharmacophore that includes covalent engagement of IPO5, is an inhibitor of influenza A replication.

S. Barluenga, N. Winssinger, Rémi Patouret, 2022, Bioorganic & medicinal chemistry.

Suprastapled Peptides: Hybridization-Enhanced Peptide Ligation and Enforced α-Helical Conformation for Affinity Selection of Combinatorial Libraries.

S. Barluenga, N. Winssinger, P. Raia, 2021, Journal of the American Chemical Society.

PNA-Based Dynamic Combinatorial Libraries (PDCL) and screening of lectins.

A. Imberty, J. Daguer, S. Barluenga, 2020, Bioorganic & medicinal chemistry.

Allosterically Regulated Phosphatase Activity from Peptide-PNA Conjugates Folded Through Hybridization.

S. Dutt, N. Winssinger, Takuya Machida, 2016, Angewandte Chemie.

PNA‐Encoded Synthesis (PES) of a 10 000‐Member Hetero‐Glycoconjugate Library and Microarray Analysis of Diverse Lectins

A. Imberty, S. Barluenga, N. Winssinger, 2014, Chembiochem : a European journal of chemical biology.

Cell-Penetrating Streptavidin: A General Tool for Bifunctional Delivery with Spatiotemporal Control, Mediated by Transport Systems Such as Adaptive Benzopolysulfane Networks

E. Derivery, M. Gonzalez-Gaitan, S. Matile, 2020, Journal of the American Chemical Society.

Peptide nucleic acid-templated selenocystine–selenoester ligation enables rapid miRNA detection† †Electronic supplementary information (ESI) available: Materials and methods, compound characterisation, data for ligation reactions and miRNA detection. See DOI: 10.1039/c7sc02736b

R. Payne, N. Winssinger, J. Sayers, 2017, Chemical science.

Solid- and solution-phase synthesis of vancomycin and vancomycin analogues with activity against vancomycin-resistant bacteria.

R. Hughes, K. Nicolaou, N. Winssinger, 2001, Chemistry.

The RB596 antibody recognizes a linear epitope from the spike S protein from SARS-CoV-2

J. Daguer, S. Barluenga, N. Winssinger, 2020 .

SARS‐CoV‐2 infection as a trigger of humoral response against apolipoprotein A‐1

S. Yerly, I. Guessous, S. Stringhini, 2021, European journal of clinical investigation.

SARS-COV2- infection as a trigger of humoral response against apolipoprotein A-1

I. Guessous, S. Stringhini, J. Pugin, 2021, Atherosclerosis.

Site-Specific Glycoconjugation of Protein via Bioorthogonal Tetrazine Cycloaddition with a Genetically Encoded trans-Cyclooctene or Bicyclononyne

J. Chin, Kathrin Lang, N. Winssinger, 2015, Bioconjugate chemistry.

Luciferase-induced photoreductive uncaging of small-molecule effectors

N. Winssinger, E. Lindberg, Simona Angerani, 2018, Nature Communications.

Duplex formation and secondary structure of γ-PNA observed by NMR and CD.

S. Barluenga, N. Winssinger, M. Delsuc, 2015, Biophysical chemistry.

Clickable peptide nucleic acids (cPNA) with tunable affinity.

S. Barluenga, N. Winssinger, Dalila Chouikhi, 2010, Chemical communications.

Expanding the Scope and Orthogonality of PNA Synthesis

Z. Pianowski, N. Winssinger, S. Pothukanuri, 2008 .

Fluorescence-based detection of single nucleotide permutation in DNA via catalytically templated reaction.

Z. Pianowski, N. Winssinger, 2007, Chemical communications.

Divergent syntheses of resorcylic acid lactones: L-783277, LL-Z1640-2, and hypothemycin.

S. Barluenga, N. Winssinger, Pierre-Yves Dakas, 2009, Chemistry.

Concise synthesis of pochonin A, an HSP90 inhibitor.

S. Barluenga, N. Winssinger, E. Moulin, 2005, Organic letters.

Solution- and solid-phase synthesis of radicicol (monorden) and pochonin C.

S. Barluenga, N. Winssinger, E. Moulin, 2005, Chemistry.

In cellulo protein labelling with Ru-conjugate for luminescence imaging and bioorthogonal photocatalysis.

N. Winssinger, K. Sadhu, E. Lindberg, 2015, Chemical communications.

Solid-Phase Synthesis of Macrocyclic Systems by a Cyclorelease Strategy: Application of the Stille Coupling to a Synthesis of (S)-Zearalenone.

K. Nicolaou, N. Winssinger, J. Pastor, 1998, Angewandte Chemie.

Concise modular asymmetric synthesis of deguelin, tephrosin and investigation into their mode of action.

L. Neckers, S. Barluenga, N. Winssinger, 2010, Chemistry.

Mitochondria-specific 1 photoactivation to monitor local 2 sphingosine metabolism and 3 function

J. Martinou, H. Riezman, S. Montessuit, 2018 .

Synthesis of Protein-Oligonucleotide Conjugates

N. Winssinger, E. E. Watson, 2022, Biomolecules.

Lysosome-targeted photoactivation reveals local sphingosine metabolism signatures† †Electronic supplementary information (ESI) available. See DOI: 10.1039/c8sc03614d

H. Riezman, J. Hannich, N. Winssinger, 2018, Chemical science.

Rapid and scalable synthesis of chiral bromolactones as precursors to α-exo-methylene-γ-butyrolactone-containing sesquiterpene lactones

N. Winssinger, R. Lagoutte, M. Pastor, 2018, Tetrahedron.

Nucleic acid templated uncaging of fluorophores using Ru-catalyzed photoreduction with visible light.

N. Winssinger, K. Górska, M. Röthlingshöfer, 2012, Organic letters.

Turn On of a Ruthenium(II) Photocatalyst by DNA-Templated Ligation.

N. Winssinger, Marcello Anzola, 2018, Chemistry.

Accelerating Turnover Frequency in Nucleic Acid Templated Reactions.

N. Winssinger, Dalu Chang, E. Lindberg, 2017, Bioconjugate chemistry.

Critical Analysis of Rate Constants and Turnover Frequency in Nucleic Acid-Templated Reactions: Reaching Terminal Velocity.

N. Winssinger, Dalu Chang, E. Lindberg, 2017, Journal of the American Chemical Society.

Selection of a synthetic glycan oligomer from a library of DNA-templated fragments against DC-SIGN and inhibition of HIV gp120 binding to dendritic cells.

O. Chaloin, J. Daguer, S. Barluenga, 2011, Chemical communications.

Combinatorial Self‐Assembly of Glycan Fragments into Microarrays

S. Barluenga, N. Winssinger, K. Górska, 2011, Chembiochem : a European journal of chemical biology.

Novel strategies for the solid phase synthesis of substituted indolines and indoles.

R. Hughes, K. Nicolaou, J. Pfefferkorn, 2003, Bioorganic & medicinal chemistry.

Imaging of mRNA in live cells using nucleic acid-templated reduction of azidorhodamine probes.

Christoph A. Merten, Z. Pianowski, N. Winssinger, 2009, Journal of the American Chemical Society.

Polymer-supported selenium reagents for organic synthesis

K. Nicolaou, S. Barluenga, N. Winssinger, 1998 .

Synthesis and biological evaluation of vancomycin dimers with potent activity against vancomycin-resistant bacteria: target-accelerated combinatorial synthesis.

R. Hughes, K. Nicolaou, N. Winssinger, 2001, Chemistry.

Target-Accelerated Combinatorial Synthesis and Discovery of Highly Potent Antibiotics Effective Against Vancomycin-Resistant Bacteria.

Robert Hughes, Nicolas Winssinger, K C Nicolaou, 2000, Angewandte Chemie.

Synthesis of a resorcylic acid lactone (RAL) library using fluorous-mixture synthesis and profile of its selectivity against a panel of kinases.

S. Barluenga, N. Winssinger, Pierre-Yves Dakas, 2009, Chemistry.

Modular synthesis of radicicol A and related resorcylic acid lactones, potent kinase inhibitors.

F. Totzke, S. Barluenga, N. Winssinger, 2007, Angewandte Chemie.

Chemistry and biology of resorcylic acid lactones.

S. Barluenga, N. Winssinger, 2007, Chemical communications.

Modular asymmetric synthesis of aigialomycin D, a kinase-inhibitory scaffold.

L. Meijer, S. Barluenga, N. Winssinger, 2006, Angewandte Chemie.

Covalent inhibitors: an opportunity for rational target selectivity.

N. Winssinger, R. Lagoutte, Rémi Patouret, 2017, Current opinion in chemical biology.

Total Synthesis of Vancomycin—Part 4: Attachment of the Sugar Moieties and Completion of the Synthesis

R. Hughes, K. Nicolaou, N. Winssinger, 1999 .

Following the Lead from Nature: Divergent Pathways in Natural Product Synthesis and Diversity-Oriented Synthesis

N. Winssinger, Christelle Serba, 2013 .

Total synthesis of 16-desmethylepothilone B, epothilone B10, epothilone F, and related side chain modified epothilone B analogues.

K. Nicolaou, B. Werschkun, D. Hepworth, 2000, Chemistry.

Kinesin-1 activity recorded in living cells with a precipitating dye

N. Klena, N. Winssinger, Christopher K. E. Bleck, 2021, Nature Communications.

Kinesin-1 motility traced by an activity-based precipitating dye

N. Klena, N. Winssinger, Christopher K. E. Bleck, 2020, bioRxiv.

Allosterically Regulated Phosphatase Activity from Peptide-PNA Conjugates Folded Through Hybridization.

S. Dutt, N. Winssinger, Takuya Machida, 2016, Angewandte Chemie.

Total Synthesis of Vancomycin

R. Hughes, K. Nicolaou, N. Winssinger, 1999 .

A highly efficient azide-based protecting group for amines and alcohols.

N. Winssinger, S. Pothukanuri, 2007, Organic letters.

A General and Highly Efficient Solid Phase Synthesis of Oligosaccharides. Total Synthesis of a Heptasaccharide Phytoalexin Elicitor (HPE)

K. Nicolaou, N. Winssinger, J. Pastor, 1997 .

Activation of Cell-Penetrating Peptides with Ionpair-π Interactions and Fluorophiles.

S. Matile, P. Metrangolo, G. Resnati, 2016, Journal of the American Chemical Society.

Synthesis of a PNA-encoded cysteine protease inhibitor library

Jennifer L. Harris, François Debaene, N. Winssinger, 2004 .

SOLID AND SOLUTION PHASE SYNTHESIS AND BIOLOGICAL EVALUATION OF COMBINATORIAL SARCODICTYIN LIBRARIES

Nicolas Winssinger, Jeffrey A. Pfefferkorn, K. Nicolaou, 1998 .

Reactions templated by nucleic acids: more ways to translate oligonucleotide-based instructions into emerging function.

N. Winssinger, K. Górska, 2013, Angewandte Chemie.

DNA as a Platform to Program Assemblies with Emerging Functions in Chemical Biology

N. Winssinger, K. Sadhu, M. Röthlingshöfer, 2013 .

Coupling of DNA Circuit and Templated Reactions for Quadratic Amplification and Release of Functional Molecules.

N. Winssinger, Dalu Chang, Simona Angerani, 2019, Journal of the American Chemical Society.

Identification of a Covalent Importin-5 Inhibitor, Goyazensolide, from a Collective Synthesis of Furanoheliangolides

R. Loewith, M. Plank, S. Barluenga, 2021, ACS central science.

Rapid and Scalable Synthesis of cis-Fused Guaiane-Type Sesquiterpenes

N. Winssinger, R. Lagoutte, Christelle Serba, 2016 .

Nucleic Acid Templated Chemical Reaction in a Live Vertebrate

M. Gonzalez-Gaitan, L. Holtzer, N. Winssinger, 2016, ACS central science.

Solid Phase Synthesis of Macrocycles by an Intramolecular Ketophosphonate Reaction. Synthesis of a (dl)-Muscone Library

K. Nicolaou, N. Winssinger, J. Pastor, 1998 .

Designed Epothilones: Combinatorial Synthesis, Tubulin Assembly Properties, abd Cytotoxic Action against Taxol-Resistant Tumor Cells†

K. Nicolaou, Tianhu Li, D. Vourloumis, 1997 .

Solid phase synthesis of glycopeptides using Shoda's activation of unprotected carbohydrates.

S. Barluenga, N. Winssinger, Christelle Serba, 2013, Chemical communications.

Sphingolipids and membrane targets for therapeutics.

R. Loewith, H. Riezman, N. Winssinger, 2019, Current opinion in chemical biology.

Solid-Phase Synthesis of Oligosaccharides: Construction of a Dodecasaccharide.

K. Nicolaou, N. Winssinger, J. Pastor, 1998, Angewandte Chemie.

IPy2BF4‐Mediated Glycosylation and Glycosyl Fluoride Formation

N. Winssinger, Kuo‐Ting Huang, 2007 .

Correction: Synthesis of epothilones A and B in solid and solution phase

K. Nicolaou, P. Giannakakou, D. Vourloumis, 1997, Nature.

In Vivo Efficacy of Natural Product‐Inspired Irreversible Kinase Inhibitors

S. Barluenga, N. Winssinger, Girish K Koripelly, 2010, Chembiochem : a European journal of chemical biology.

Resorcylic acid lactones: A pluripotent scaffold with therapeutic potential

S. Barluenga, N. Winssinger, Pierre-Yves Dakas, 2008 .

Modular asymmetric synthesis of pochonin C.

S. Barluenga, N. Winssinger, E. Moulin, 2004, Angewandte Chemie.

Molecular Editing of Kinase‐Targeting Resorcylic Acid Lactones (RAL): Fluoroenone RAL

S. Barluenga, N. Winssinger, Rajamalleswaramma Jogireddy, 2010, ChemMedChem.

Screening for covalent inhibitors using DNA-display of small molecule libraries functionalized with cysteine reactive moieties

J. Daguer, C. Zambaldo, S. Barluenga, 2016 .

Design, synthesis, and biological evaluation of HSP90 inhibitors based on conformational analysis of radicicol and its analogues.

Vincent Zoete, Nicolas Winssinger, Martin Karplus, 2005, Journal of the American Chemical Society.

The Novel Hsp90 Inhibitor NXD30001 Induces Tumor Regression in a Genetically Engineered Mouse Model of Glioblastoma Multiforme

R. Bronson, A. Rubenstein, A. Charest, 2010, Molecular Cancer Therapeutics.

Cysteine mapping in conformationally distinct kinase nucleotide binding sites: application to the design of selective covalent inhibitors.

D. Moras, J. Wurtz, S. Barluenga, 2011, Journal of medicinal chemistry.

Inhibition of HSP90 as a Strategy to Radiosensitize Glioblastoma: Targeting the DNA Damage Response and Beyond

A. Walch, C. Belka, H. Zitzelsberger, 2021, Frontiers in Oncology.

Priming of Anti-tumor Immune Mechanisms by Radiotherapy Is Augmented by Inhibition of Heat Shock Protein 90

M. Sperandio, C. Belka, S. Shirasawa, 2020, Frontiers in Oncology.

HSP90 inhibition as a means of radiosensitizing resistant, aggressive soft tissue sarcomas.

C. Belka, K. Lauber, M. Orth, 2015, Cancer letters.

Double‐Stranded RNA‐Specific Templated Reaction with Triplex Forming PNA

N. Winssinger, Dalu Chang, Ki Tae Kim, 2018 .

Identification of immunodominant linear epitopes from SARS-CoV-2 patient plasma

S. Yerly, S. Pagano, L. Kaiser, 2020, medRxiv.

Kinase-templated abiotic reaction

O. Hantschel, S. Georgeon, N. Winssinger, 2017, Chemical science.

Dual Bcl-XL /Bcl-2 inhibitors discovered from DNA-encoded libraries using a fragment pairing strategy.

J. Daguer, S. Barluenga, N. Winssinger, 2021, Bioorganic & medicinal chemistry.

Chemical Genetics of AGC-kinases Reveals Shared Targets of Ypk1, Protein Kinase A and Sch9*

Markus Müller, R. Aebersold, R. Loewith, 2020, Molecular & Cellular Proteomics.

Chemical Genetics of AGC-kinases Reveals Shared Targets of Ypk1, Protein Kinase A and Sch9*

Markus Müller, R. Aebersold, R. Loewith, 2019, Molecular & Cellular Proteomics.

From Split-Pool Libraries to Spatially Addressable Microarrays and Its Application to Functional Proteomic Profiling.

Peter G Schultz, Nicolas Winssinger, P. Schultz, 2001, Angewandte Chemie.

Selective affinity-based probe for oncogenic kinases suitable for live cell imaging

J. Daguer, C. Zambaldo, S. Barluenga, 2013 .

Biosupramolecular Systems: Integrating Cues into Responses.

N. Winssinger, E. E. Watson, Simona Angerani, 2021, Journal of the American Chemical Society.

Polyubiquitination of Transforming Growth Factor β (TGFβ)-associated Kinase 1 Mediates Nuclear Factor-κB Activation in Response to Different Inflammatory Stimuli*

C. Heldin, A. Hamidi, S. Barluenga, 2011, The Journal of Biological Chemistry.

Pseudo-Complementary G:C Base Pair for Mixed Sequence dsDNA Invasion and Its Applications in Diagnostics (SARS-CoV-2 Detection)

S. Barluenga, N. Winssinger, Miguel López-Tena, 2023, JACS Au.

Photoreductive uncaging of fluorophore in response to protein oligomers by templated reaction in vitro and in cellulo.

T. Eierhoff, W. Römer, N. Winssinger, 2012, Journal of the American Chemical Society.

Probing Biology with Small Molecule Microarrays (SMM)

Nicolas Winssinger, Zbigniew Pianowski, François Debaene, 2007, Combinatorial Chemistry on Solid Supports.

Self-assembly of PNA-encoded peptides into microarrays.

François Debaene, N. Winssinger, 2009, Methods in molecular biology.

Microarray-based functional protein profiling using peptide nucleic acid-encoded libraries

Jennifer L. Harris, N. Winssinger, 2005, Expert review of proteomics.

Mitochondria-specific photoactivation to monitor local sphingosine metabolism and function

J. Martinou, H. Riezman, S. Montessuit, 2018, eLife.

Synthesis of Epothilones A and B in Solid and Solution Phase.

K. Nicolaou, Tianhu Li, P. Giannakakou, 1997 .

DNA display of glycoconjugates to emulate oligomeric interactions of glycans

N. Winssinger, A. Novoa, 2015, Beilstein journal of organic chemistry.

Caprin‐1 Promotes Cellular Uptake of Nucleic Acids with Backbone and Sequence Discrimination

A. Roux, N. Winssinger, K. Sadhu, 2019 .

Self-assembled antibody multimers through peptide nucleic acid conjugation.

Chan Hyuk Kim, P. Schultz, S. Barluenga, 2013, Journal of the American Chemical Society.

Luciferase-Induced Photouncaging: Bioluminolysis.

H. Riezman, N. Winssinger, Dalu Chang, 2019, Angewandte Chemie.

Self‐Assembled Small‐Molecule Microarrays for Protease Screening and Profiling

Jennifer L. Harris, C. Bole-Feysot, François Debaene, 2006, Chembiochem : a European journal of chemical biology.

Combining recombinase polymerase amplification and DNA‐templated reaction for SARS‐CoV‐2 sensing with dual fluorescence and lateral flow assay output

S. Barluenga, N. Winssinger, Ki Tae Kim, 2022, Biopolymers.

Autoactivation of Transforming Growth Factor β-activated Kinase 1 Is a Sequential Bimolecular Process*

Ramon F. Thali, R. Scholz, D. Neumann, 2010, The Journal of Biological Chemistry.

The Art and Science of Organic and Natural Products Synthesis

K. Nicolaou, E. J. Sorensen, N. Winssinger, 1998 .

Total Synthesis of Vancomycin

R. Hughes, K. Nicolaou, N. Winssinger, 1999 .

Smartphone DNA or RNA-Sensing Using Semisynthetic Luciferase-Based Logic Device.

Ki Tae Kim, Dalu Chang, Eric Lindberg, 2020, ACS sensors.

Sense-and-release Logic-gated Molecular Network Responding to Dimeric Cell Surface Proteins.

N. Winssinger, Simona Angerani, 2020, Journal of the American Chemical Society.

Applications of laser-polarized 129Xe to biomolecular assays.

P. Schultz, A. Pines, D. Wemmer, 2003, Magnetic resonance imaging.

Oligonucleotide Phosphorothioates Enter Cells by Thiol‐Mediated Uptake

S. Matile, N. Sakai, N. Winssinger, 2021, Angewandte Chemie.

PNA-encoded chemical libraries.

C. Zambaldo, S. Barluenga, N. Winssinger, 2015, Current opinion in chemical biology.

Detection of miRNA in live cells by using templated RuII-catalyzed unmasking of a fluorophore.

N. Winssinger, K. Sadhu, 2013, Chemistry.

PNA encoding (PNA=peptide nucleic acid): from solution-based libraries to organized microarrays.

Jennifer L. Harris, N. Winssinger, 2005, Chemistry.

Luciferase-induced photoreductive uncaging of small-molecule effectors

N. Winssinger, E. Lindberg, Simona Angerani, 2018, Nature Communications.

Probing for Thiol‐Mediated Uptake into Bacteria

S. Matile, N. Sakai, S. Barluenga, 2020, Chembiochem : a European journal of chemical biology.

Epothilones and Sarcodictyins: From Combinatorial Libraries to Designed Analogs

K. Nicolaou, N. Winssinger, 2001 .

A mating mechanism to generate diversity for the Darwinian selection of DNA-encoded synthetic molecules

J. Daguer, S. Barluenga, N. Winssinger, 2021, Nature Chemistry.

Synthesis of α-exo-Methylene-γ-butyrolactones: Recent Developments and Applications in Natural Product Synthesis

N. Winssinger, Weilong Liu, 2021, Synthesis.

Chemistry and Biology of Resorcylic Acid Lactones

S. Barluenga, N. Winssinger, 2007 .

Flipper Probes for the Community.

S. Manley, L. Reymond, S. Pitsch, 2021, Chimia.

Ligand dimerization programmed by hybridization to study multimeric ligand-receptor interactions.

J. Beyrath, S. Fournel, G. Guichard, 2010, Chemical communications.

Activity profile of dust mite allergen extract using substrate libraries and functional proteomic microarrays.

Aaron Shipway, Jennifer L. Harris, A. Ghaemmaghami, 2004, Chemistry & biology.

A minimal hybridization chain reaction (HCR) system using peptide nucleic acids

N. Winssinger, Simona Angerani, Ki Tae Kim, 2021, Chemical science.

Novel PTP1B inhibitors identified by DNA display of fragment pairs.

J. Daguer, C. Zambaldo, S. Barluenga, 2016, Bioorganic & medicinal chemistry letters.

PNA as a Biosupramolecular Tag for Programmable Assemblies and Reactions.

S. Barluenga, N. Winssinger, 2015, Accounts of chemical research.

Expanding the scope of PNA-encoded synthesis (PES): Mtt-protected PNA fully orthogonal to fmoc chemistry and a broad array of robust diversity-generating reactions.

Nicolas Winssinger, Mihai Ciobanu, Sofia Barluenga, 2012, Chemistry.

DNA display of PNA-tagged ligands

N. Winssinger, 2012, Artificial DNA PNA & XNA.

Discovery of an entropically-driven small molecule streptavidin binder from nucleic acid-encoded libraries.

J. Daguer, S. Barluenga, N. Winssinger, 2012, Organic & biomolecular chemistry.

DNA-templated combinatorial assembly of small molecule fragments amenable to selection/amplification cycles

J. Daguer, S. Barluenga, N. Winssinger, 2011 .

Selection of bead‐displayed, PNA‐encoded chemicals

J. P. Nelli, M. Guthold, Z. Pianowski, 2010, Journal of molecular recognition : JMR.

PNA-Encoded Synthesis (PES) and DNA Display of Small Molecule Libraries.

Nicolas Winssinger, Jacques Saarbach, Sofia Barluenga, 2020, Methods in molecular biology.

DNA display of PNA-tagged ligands : A versatile strategy to screen libraries and control geometry of multidentate ligands

N. Winssinger, 2017 .

Dynamic Cooperative Glycan Assembly Blocks the Binding of Bacterial Lectins to Epithelial Cells.

Anne Imberty, Nicolas Winssinger, A. Imberty, 2017, Angewandte Chemie.

DNA-templated homo- and heterodimerization of peptide nucleic acid encoded oligosaccharides that mimick the carbohydrate epitope of HIV.

O. Chaloin, N. Winssinger, K. Górska, 2009, Angewandte Chemie.

Nucleic acid-tagged peptides: encoding libraries and controlling dimerization and conformation.

N. Winssinger, K. Sadhu, 2013, Chimia.

Rapid fluorescence imaging of miRNAs in human cells using templated Staudinger reaction

I. Keklikoglou, U. Tschulena, N. Winssinger, 2011 .

Kinase-templated abiotic reaction† †Electronic supplementary information (ESI) available. See DOI: 10.1039/c7sc01416c Click here for additional data file.

O. Hantschel, S. Georgeon, N. Winssinger, 2017, Chemical science.

Following the Lead from Nature with Covalent Inhibitors.

N. Winssinger, R. Lagoutte, 2017, Chimia.

Small-molecule modulators of the ATPase VCP/p97 affect specific p97 cellular functions.

M. Gotta, J. Daguer, S. Barluenga, 2019, ACS chemical biology.

Chemistry, Biology, and Medicine of the Glycopeptide Antibiotics.

K. Nicolaou, N. Winssinger, C. Boddy, 1999, Angewandte Chemie.

The Art and Science of Total Synthesis at the Dawn of the Twenty-First Century.

Baran, K. Nicolaou, D. Vourloumis, 2000, Angewandte Chemie.

Picture Perfect: DNA‐Templated Photoaffinity Labeling

S. Barluenga, N. Winssinger, 2013, Chembiochem : a European journal of chemical biology.

Nucleic acid-templated energy transfer leading to a photorelease reaction and its application to a system displaying a nonlinear response.

N. Winssinger, K. Górska, M. Röthlingshöfer, 2011, Journal of the American Chemical Society.

Cysteine mapping in conformationally distinct kinase nucleotide binding sites: application to the design of selective covalent inhibitors.

D. Moras, J. Wurtz, S. Barluenga, 2011, Journal of medicinal chemistry.

DNA display of fragment pairs as a tool for the discovery of novel biologically active small molecules† †Electronic supplementary information (ESI) available. See DOI: 10.1039/c4sc01654h

J. Daguer, C. Zambaldo, S. Barluenga, 2014, Chemical science.

Synthesis of deguelin-biotin conjugates and investigation into deguelin's interactions.

S. Barluenga, N. Winssinger, F. Sasse, 2012, Bioorganic & medicinal chemistry.

The Novel Hsp90 Inhibitor NXD30001 Induces Tumor Regression in a Genetically Engineered Mouse Model of Glioblastoma Multiforme

R. Bronson, A. Rubenstein, A. Charest, 2010, Molecular Cancer Therapeutics.

Reactions templated by nucleic acids: more ways to translate oligonucleotide-based instructions into emerging function.

N. Winssinger, K. Górska, 2013, Angewandte Chemie.

Hsp90 inhibition with resorcyclic acid lactones (RALs).

S. Barluenga, N. Winssinger, J. Fontaine, 2009, Current topics in medicinal chemistry.