W. Wasco

发表

Cloning of a gene bearing missense mutations in early-onset familial Alzheimer's disease

D. Pollen, J. Haines, M. Pericak-Vance, 1995, Nature.

Candidate gene for the chromosome 1 familial Alzheimer's disease locus

G. Schellenberg, E. Wijsman, D. Galas, 1995, Science.

Participation of Presenilin 2 in Apoptosis: Enhanced Basal Activity Conferred by an Alzheimer Mutation

T. Sunderland, P. Vito, B. Zhao, 1996, Science.

Mapping, cloning and genetic characterization of the region containing the Wilson disease gene

J. Ott, T. Gilliam, M. Devoto, 1993, Nature Genetics.

gamma-Secretase cleavage and binding to FE65 regulate the nuclear translocation of the intracellular C-terminal domain (ICD) of the APP family of proteins.

D. Selkoe, D. Walsh, J. Fadeeva, 2003, Biochemistry.

The upstream stimulatory factor functionally interacts with the Alzheimer amyloid beta-protein precursor gene.

R. Tanzi, R. Roeder, D. Kovacs, 1995, Human molecular genetics.

Isolation and characterization of APLP2 encoding a homologue of the Alzheimer's associated amyloid beta protein precursor.

B. Hyman, R. Tanzi, R. Neve, 1993, Nature genetics.

The amyloid precursor-like protein (APLP) gene maps to the long arm of human chromosome 19.

R. Tanzi, W. Wasco, J. Brook, 1993, Genomics.

Calsenilin is degraded by the ubiquitin-proteasome pathway.

J. Buxbaum, J. Choi, Yong-Sun Kim, 2011, Biochemical and biophysical research communications.

Calsenilin Enhances Apoptosis by Altering Endoplasmic Reticulum Calcium Signaling

J. Buxbaum, M. Mattson, W. Wasco, 2002, Molecular and Cellular Neuroscience.

Familial Alzheimer's chromosome 14 mutations

J. Growdon, R. Tanzi, S. Schmidt, 1995, Nature Medicine.

Isolation, characterization, and mapping of gene encoding dihydrolipoyl succinyltransferase (E2k) of humanα-ketoglutarate dehydrogenase complex

R. Tanzi, J. Gusella, J. Blass, 1994, Somatic cell and molecular genetics.

Isolation and characterization of APLP2 encoding a homologue of the Alzheimer's associated amyloid β protein precursor

B. Hyman, R. Tanzi, R. Neve, 1993, Nature Genetics.

Alternative Endoproteolysis of the Presenilins and Familial Alzheimer’s Disease

R. Tanzi, D. Kovacs, W. Wasco, 1998 .

Assessment of amyloid beta-protein precursor gene mutations in a large set of familial and sporadic Alzheimer disease cases.

J. Haines, B. Hyman, R. Tanzi, 1992, American journal of human genetics.

The amyloid beta-protein precursor and its mammalian homologues. Evidence for a zinc-modulated heparin-binding superfamily.

R. Tanzi, A. Bush, W. Pettingell, 1994, The Journal of biological chemistry.

Genomic structure, expression pattern, and chromosomal localization of the human calsenilin gene: no association between an exonic polymorphism and Alzheimer's disease

J. Buxbaum, D. Blacker, S. Bassett, 2000, Neuroscience Letters.

Chitin and nodulation

C. Bulawa, W. Wasco, CHRISTINE E. BULAWA, 1991, Nature.

Calsenilin regulates presenilin 1/γ‐secretase‐mediated N‐cadherin ∊‐cleavage and β‐catenin signaling

J. Buxbaum, J. Choi, Yong-Sun Kim, 2011, FASEB journal : official publication of the Federation of American Societies for Experimental Biology.

Phosphorylation of calsenilin at Ser63 regulates its cleavage by caspase-3

J. Buxbaum, J. Miller, W. Wasco, 2003, Molecular and Cellular Neuroscience.

Calsenilin-Presenilin Interaction in Alzheimer’s Disease

J. Buxbaum, W. Wasco, E. Choi, 2002 .

Developmental Regulation of Presenilin mRNA Expression Parallels Notch Expression

B. Hyman, R. Tanzi, O. Berezovska, 1997, Journal of neuropathology and experimental neurology.

Reduced amyloidogenic processing of the amyloid beta-protein precursor by the small-molecule Differentiation Inducing Factor-1.

R. Tanzi, Kevin J. Washicosky, Michael A. Myre, 2009, Cellular signalling.

Calsenilin interacts with transcriptional co‐repressor C‐terminal binding protein(s)

J. Buxbaum, Kevin J. Washicosky, W. Wasco, 2006, Journal of neurochemistry.

Calcium-regulated DNA Binding and Oligomerization of the Neuronal Calcium-sensing Protein, Calsenilin/DREAM/KChIP3*

J. Buxbaum, M. Ikura, J. Penninger, 2001, The Journal of Biological Chemistry.

Selective localization of amyloid precursor-like protein 1 in the cerebral cortex postsynaptic density.

I. Black, R. Tanzi, K. Wu, 1995, Brain research. Molecular brain research.

Immunogold localization of the regulatory subunit of a type II cAMP- dependent protein kinase tightly associated with mammalian sperm flagella

P. Satir, W. Wasco, G. Orr, 1988, The Journal of cell biology.

Identification of a mouse brain cDNA that encodes a protein related to the Alzheimer disease-associated amyloid beta protein precursor.

R. Tanzi, J. Gusella, F. Solomon, 1992, Proceedings of the National Academy of Sciences of the United States of America.

Secreted amyloid β–protein similar to that in the senile plaques of Alzheimer's disease is increased in vivo by the presenilin 1 and 2 and APP mutations linked to familial Alzheimer's disease

G. Schellenberg, J. Hardy, M. Viitanen, 1996, Nature Medicine.

Alzheimer–associated presenilins 1 and 2 : Neuronal expression in brain and localization to intracellular membranes in mammalian cells

B. Hyman, R. Tanzi, D. Kovacs, 1996, Nature Medicine.

Biochemical and immunocytochemical characterization of calsenilin in mouse brain

J. Buxbaum, B. Hyman, O. Berezovska, 2002, Neuroscience.

Subcellular localization of presenilin 2 endoproteolytic C-terminal fragments.

J. Buxbaum, D. Ausiello, W. Xia, 2001, Brain research. Molecular brain research.

Calsenilin: A calcium-binding protein that interacts with the presenilins and regulates the levels of a presenilin fragment

J. Buxbaum, W. Wasco, Yuxia Luo, 1998, Nature Medicine.

Presenilin 2 — APP Interactions

R. Tanzi, W. Wasco, D. Romano, 1998 .

A novel presenilin‐1 mutation: Increased β‐amyloid and neurofibrillary changes

J. Growdon, B. Hyman, R. Tanzi, 1997 .

Endoproteolytic Cleavage and Proteasomal Degradation of Presenilin 2 in Transfected Cells*

R. Tanzi, W. Pettingell, W. Wasco, 1997, The Journal of Biological Chemistry.

Etiological Clues from Gene Defects Causing Early Onset Familial Alzheimer’s Disease

R. Tanzi, W. Wasco, 1997 .

Identification and characterization of calmodulin-binding proteins in mammalian sperm flagella.

R. Kincaid, W. Wasco, G. Orr, 1989, The Journal of biological chemistry.

Deficiency of Huntingtin Has Pleiotropic Effects in the Social Amoeba Dictyostelium discoideum

M. MacDonald, J. Gusella, Michael A. Myre, 2011, PLoS genetics.

Secreted amyloid beta-protein similar to that in the senile plaques of Alzheimer's disease is increased in vivo by the presenilin 1 and 2 and APP mutations linked to familial Alzheimer's disease.

J. Hardy, M. Viitanen, D. Selkoe, 1996, Nature medicine.

Calsenilin, a Presenilin Interactor, Regulates RhoA Signaling and Neurite Outgrowth

J. Buxbaum, Jae-Bong Park, Yong-Sun Kim, 2018, International journal of molecular sciences.

Genetic heterogeneity of gene defects responsible for familial Alzheimer disease

R. Tanzi, A. Bush, W. Pettingell, 2005, Genetica.

Phosphorylation of Alzheimer beta-amyloid precursor-like proteins.

P. Greengard, A. Nairn, Y. Kirino, 1997, Biochemistry.

Silencing of the Drosophila ortholog of SOX5 in heart leads to cardiac dysfunction as detected by optical coherence tomography.

James G Fujimoto, Christopher J O'Donnell, Airong Li, 2013, Human molecular genetics.

Quantification of APP and APLP2 mRNA in APOE genotyped Alzheimer's disease brains.

B. Winblad, R. Ravid, L. Lannfelt, 1996, Brain research. Molecular brain research.

Search for the Genes Responsible for Familial Alzheimer's Disease

R. Tanzi, J. Peppercorn, W. Wasco, 1993, Annals of the New York Academy of Sciences.

Function of calmodulin in mammalian sperm: presence of a calmodulin-dependent cyclic nucleotide phosphodiesterase associated with demembranated rat caudal epididymal sperm.

W. Wasco, G. Orr, 1984, Biochemical and biophysical research communications.

The Wilson disease gene is a copper transporting ATPase with homology to the Menkes disease gene

J. Peppercorn, L. Pavone, B. Honig, 1993, Nature Genetics.

Genetic studies of Alzheimer's disease: Lessons learned and future imperatives

R. Tanzi, A. Bush, W. Wasco, 1994, Neurobiology of Aging.

The Diverse Molecular Nature of Inherited Alzheimer’s Disease

J. Haines, R. Tanzi, P. George-Hyslop, 1994 .

Loss of Ataxin-1 Potentiates Alzheimer’s Pathogenesis by Elevating Cerebral BACE1 Transcription

H. Zoghbi, J. Schmahmann, R. Tanzi, 2019, Cell.

Interaction of the regulatory subunit of a type II cAMP-dependent protein kinase with mammalian sperm flagellum.

W. Wasco, G. Orr, M. Leiser, 1988, The Journal of biological chemistry.

Molecular Mechanisms of Dementia

R. Tanzi, R. Friedland, W. Wasco, 1997, Nature Medicine.

Calsenilin reverses presenilin-mediated enhancement of calcium signaling.

J. Buxbaum, F. LaFerla, M. Leissring, 2000, Proceedings of the National Academy of Sciences of the United States of America.

Altered A Formation and Long-Term Potentiation in a Calsenilin Knock-Out

J. Buxbaum, V. Haroutunian, M. Gomez-Ramirez, 2003 .

REVIEWThe Gene Defects Responsible for Familial Alzheimer's Disease

R. Tanzi, D. Kovacs, W. Wasco, 1996, Neurobiology of Disease.

The APP family of proteins: similarities and differences.

D. Selkoe, D. Walsh, J. Fadeeva, 2007, Biochemical Society transactions.

A novel protein, amyloid precursor-like protein 2, is present in human brain, cerebrospinal fluid and conditioned media.

R. Tanzi, F. Sherriff, P. Francis, 1995, The Biochemical journal.

Calsenilin Is a Substrate for Caspase-3 That Preferentially Interacts with the Familial Alzheimer's Disease-associated C-terminal Fragment of Presenilin 2*

J. Buxbaum, W. Wasco, E. Choi, 2001, The Journal of Biological Chemistry.

The gene defects responsible for familial Alzheimer's disease.

R. Tanzi, D. Kovacs, W. Wasco, 1996, Neurobiology of disease.

A novel presenilin-1 mutation: increased beta-amyloid and neurofibrillary changes.

M McNamara, B T Hyman, B. Hyman, 1997, Annals of neurology.

Type 4 OFF cone bipolar cells of the mouse retina express calsenilin and contact cones as well as rods

H. Wässle, S. Haverkamp, J. Brandstätter, 2008, The Journal of comparative neurology.

Intracellular calcium modulates the nuclear translocation of calsenilin

J. Buxbaum, W. Wasco, E. Choi, 2004, Journal of neurochemistry.

Expression of calsenilin in neurons and astrocytes in the Alzheimer's disease brain

J. Buxbaum, J. Choi, R. Carp, 2005, Neuroreport.

Immunohistochemical and in situ analysis of amyloid precursor-like protein-1 and amyloid precursor-like protein-2 expression in Alzheimer disease and aged control brains

B. Hyman, R. Tanzi, M. McNamara, 1998, Brain Research.

Biochemical and immunological characterization of the flagellar-associated regulatory subunit of a type II cyclic adenosine 5'-monophosphate-dependent protein kinase.

M. Paupard, W. Wasco, P. Voulalas, 1989, Archives of biochemistry and biophysics.

Major 56,000‐dalton, soluble phosphoprotein present in bovine sperm is the regulatory subunit of a type II cAMP‐dependent protein kinase

M. Paupard, W. Wasco, G. Orr, 1988, Journal of cellular biochemistry.

Genetic heterogeneity of gene defects responsible for familial Alzheimer disease.

R. Tanzi, A. Bush, W. Pettingell, 1993 .

Mutation : Increased P-Amyloid and Neurofibrillary Changes

D. Schenk, P. Seubert, M. McNamara, 2004 .

624 Proteolytic processing of wild-type and mutant forms of presenilin 2

R. Tanzi, W. Wasco, W. Pettingell, 1996, Neurobiology of Aging.