A. Lenaerts

发表

Digital Image Analysis of Heterogeneous Tuberculosis Pulmonary Pathology in Non-Clinical Animal Models using Deep Convolutional Neural Networks

A. Ben-Hur, G. Robertson, Bryce C Asay, 2020, Scientific Reports.

Bayesian models leveraging bioactivity and cytotoxicity information for drug discovery.

Barry A. Bunin, Joel S. Freundlich, Lisa K. Woolhiser, 2013, Chemistry & biology.

Discovery of Q203, a potent clinical candidate for the treatment of tuberculosis

Se Yeon Kim, R. Wintjens, J. Cechetto, 2013, Nature Medicine.

A Physiologically Based Pharmacokinetic Model of Rifampin in Mice

Brad Reisfeld, Raymond S. H. Yang, Michael A. Lyons, 2013, Antimicrobial Agents and Chemotherapy.

Importance of Confirming Data on the In Vivo Efficacy of Novel Antibacterial Drug Regimens against Various Strains of Mycobacterium tuberculosis

Lisa K. Woolhiser, I. Orme, A. Lenaerts, 2011, Antimicrobial Agents and Chemotherapy.

A Novel Metabolite of Antituberculosis Therapy Demonstrates Host Activation of Isoniazid and Formation of the Isoniazid-NAD+ Adduct

John L. Johnson, Lisa K. Woolhiser, J. Belisle, 2012, Antimicrobial Agents and Chemotherapy.

In vitro and in vivo antimycobacterial activities of ketone and amide derivatives of quinoxaline 1,4-di-N-oxide.

S. Franzblau, A. Lenaerts, R. Villar, 2008, The Journal of antimicrobial chemotherapy.

Efficacy of Quinoxaline-2-Carboxylate 1,4-Di-N-Oxide Derivatives in Experimental Tuberculosis

S. Franzblau, A. Lenaerts, R. Villar, 2008, Antimicrobial Agents and Chemotherapy.

In Vivo Adaptation of the Wayne Model of Latent Tuberculosis

Lisa K. Woolhiser, I. Orme, J. Belisle, 2007, Infection and Immunity.

Evaluation of a 2-Pyridone, KRQ-10018, against Mycobacterium tuberculosis In Vitro and In Vivo

Lisa K. Woolhiser, I. Orme, A. Lenaerts, 2008, Antimicrobial Agents and Chemotherapy.

Spiropyrimidinetriones: a Class of DNA Gyrase Inhibitors with Activity against Mycobacterium tuberculosis and without Cross-Resistance to Fluoroquinolones

K. Chibale, G. Basarab, G. Robertson, 2022, Antimicrobial agents and chemotherapy.

1,3-Diarylpyrazolyl-acylsulfonamides as Potent Anti-tuberculosis Agents Targeting Cell Wall Biosynthesis in Mycobacterium tuberculosis.

T. Myers, C. Eyermann, K. Chibale, 2021, Journal of medicinal chemistry.

Synthesis, Structure–Activity Relationship, and Mechanistic Studies of Aminoquinazolinones Displaying Antimycobacterial Activity

K. Chibale, Dale Taylor, T. Ioerger, 2020, ACS infectious diseases.

Intracellular and in vivo evaluation of imidazo[2,1-b]thiazole-5-carboxamide anti-tuberculosis compounds

A. Lenaerts, L. Woolhiser, Marvin J. Miller, 2020, PloS one.

Statistical limitations to the Cornell model of latent tuberculosis infection for the study of relapse rates.

I. Orme, A. Lenaerts, P. Chapman, 2004, Tuberculosis.

In Vivo Efficacy of Apramycin in Murine Infection Models

A. Lenaerts, E. Böttger, M. Scherman, 2014, Antimicrobial Agents and Chemotherapy.

Oral Therapy Using Nanoparticle-Encapsulated Antituberculosis Drugs in Guinea Pigs Infected with Mycobacterium tuberculosis

I. Orme, R. Pandey, R. Basaraba, 2005, Antimicrobial Agents and Chemotherapy.

A microbiological assessment of novel nitrofuranylamides as anti-tuberculosis agents.

B. Meibohm, S. Franzblau, A. Lenaerts, 2008, The Journal of antimicrobial chemotherapy.

Susceptibility of Mycobacterium abscessus to Antimycobacterial Drugs in Preclinical Models

K. Andries, A. Lenaerts, Marcela Henao-Tamayo, 2015, Antimicrobial Agents and Chemotherapy.

Pentacyclic Nitrofurans with In Vivo Efficacy and Activity against Nonreplicating Mycobacterium tuberculosis

Lisa K. Woolhiser, B. Meibohm, A. Lenaerts, 2014, PloS one.

Rapid Microbiologic and Pharmacologic Evaluation of Experimental Compounds against Mycobacterium tuberculosis

I. Orme, D. Crick, A. Lenaerts, 2006, Antimicrobial Agents and Chemotherapy.

Pyrazolo[1,5- a]pyridine Inhibitor of the Respiratory Cytochrome bcc Complex for the Treatment of Drug-Resistant Tuberculosis.

Xiaoyun Lu, Zhe Wang, A. Lenaerts, 2018, ACS infectious diseases.

Screening a library of 1600 adamantyl ureas for anti-Mycobacterium tuberculosis activity in vitro and for better physical chemical properties for bioavailability.

E. J. North, C. Morisseau, M. Jackson, 2012, Bioorganic & medicinal chemistry.

Discovery of selective menaquinone biosynthesis inhibitors against Mycobacterium tuberculosis.

S. Franzblau, D. Crick, A. Lenaerts, 2012, Journal of medicinal chemistry.

Activities of TMC207, Rifampin, and Pyrazinamide against Mycobacterium tuberculosis Infection in Guinea Pigs

I. Orme, David F. Ackart, Laurel Hascall-Dove, 2010, Antimicrobial Agents and Chemotherapy.

Activities of TMC 207 , Rifampin , and Pyrazinamide against Mycobacterium tuberculosis Infection in Guinea Pigs

I. Orme, David F. Ackart, Laurel Hascall-Dove, 2010 .

Delamanid or pretomanid? A Solomonic judgement!

H. Bax, A. Lenaerts, J. D. de Steenwinkel, 2022, The Journal of antimicrobial chemotherapy.

Host-Mediated Bioactivation of Pyrazinamide: Implications for Efficacy, Resistance, and Therapeutic Alternatives.

Jeong Su Cho, T. Shim, M. Zimmerman, 2015, ACS infectious diseases.

Mouse Model for Efficacy Testing of Antituberculosis Agents via Intrapulmonary Delivery

M. Gonzalez-Juarrero, A. Lenaerts, L. Woolhiser, 2012, Antimicrobial Agents and Chemotherapy.

In vitro and in vivo Evaluation of Synergism between Anti-Tubercular Spectinamides and Non-Classical Tuberculosis Antibiotics

B. Meibohm, A. Lenaerts, E. Böttger, 2015, Scientific Reports.

The Tuberculosis Drug Accelerator at year 10: what have we learned?

H. M. Petrassi, Christopher B. Cooper, Robert H Bates, 2021, Nature Medicine.

Comparative Analysis of Pharmacodynamics in the C3HeB/FeJ Mouse Tuberculosis Model for DprE1 Inhibitors TBA-7371, PBTZ169, and OPC-167832

Lisa K. Woolhiser, G. Robertson, Michelle E. Ramey, 2021, Antimicrobial agents and chemotherapy.

Heterogeneous disease progression and treatment response in a C3HeB/FeJ mouse model of tuberculosis

A. Lenaerts, E. Nuermberger, J. Lanoix, 2015, Disease Models & Mechanisms.

Synthesis and evaluation of pretomanid (PA-824) oxazolidinone hybrids.

A. Lenaerts, Richard E. Lee, Jiuyu Liu, 2016, Bioorganic & medicinal chemistry letters.

Presence of multiple lesion types with vastly different microenvironments in C3HeB/FeJ mice following aerosol infection with Mycobacterium tuberculosis

M. Gonzalez-Juarrero, R. Basaraba, A. Lenaerts, 2015, Disease Models & Mechanisms.

Lipoarabinomannan Localization and Abundance during Growth of Mycobacterium smegmatis

D. Crick, Premkumar Dinadayala, A. Lenaerts, 2011, Journal of bacteriology.

Model-Based Meta-Analysis of Relapsing Mouse Model Studies from the Critical Path to Tuberculosis Drug Regimens Initiative Database

Michelle E. Ramey, A. Lenaerts, N. Ammerman, 2021, bioRxiv.

Imaging and spatially resolved quantification of drug distribution in tissues by mass spectrometry.

A. Lenaerts, V. Dartois, Brendan Prideaux, 2018, Current opinion in chemical biology.

Isolation and purification of Mycobacterium tuberculosis from H37Rv infected guinea pig lungs.

J. Belisle, A. Izzo, D. Crick, 2014, Tuberculosis.

Host Directed Therapy for Chronic Tuberculosis via Intrapulmonary Delivery of Aerosolized Peptide Inhibitors Targeting the IL-10-STAT3 Pathway

C. Wilusz, K. Stefanisko, N. Tarasova, 2018, Scientific Reports.

In vitro and in vivo antimycobacterial activities of ketone and amide derivatives of quinoxaline 1 , 4-diN-oxide

S. Franzblau, A. Lenaerts, R. Villar, 2008 .

Antitubercular nitrofuran isoxazolines with improved pharmacokinetic properties.

B. Meibohm, A. Lenaerts, M. McNeil, 2012, Bioorganic & medicinal chemistry.

Computational pharmacokinetics/pharmacodynamics of rifampin in a mouse tuberculosis infection model

A. Lenaerts, M. Lyons, 2015, Journal of Pharmacokinetics and Pharmacodynamics.

Evaluation of Moxifloxacin-Containing Regimens in Pathologically Distinct Murine Tuberculosis Models

A. Lenaerts, P. Converse, K. Mdluli, 2015, Antimicrobial Agents and Chemotherapy.

Bedaquiline and Pyrazinamide Treatment Responses Are Affected by Pulmonary Lesion Heterogeneity in Mycobacterium tuberculosis Infected C3HeB/FeJ Mice

M. Zimmerman, M. Voskuil, K. Andries, 2016, ACS infectious diseases.

Comparative Studies Evaluating Mouse Models Used for Efficacy Testing of Experimental Drugs against Mycobacterium tuberculosis

Lisa K. Woolhiser, I. Orme, A. Lenaerts, 2010, Antimicrobial Agents and Chemotherapy.

Bioactive pyridine-N-oxide disulfides from Allium stipitatum.

Stephen Neidle, Simon Gibbons, Mekala Gunaratnam, 2009, Journal of natural products.

Effects of P-MAPA Immunomodulator on Toll-Like Receptors and p53: Potential Therapeutic Strategies for Infectious Diseases and Cancer

Lisa K. Woolhiser, N. Durán, A. Lenaerts, 2012, Infectious Agents and Cancer.

Comprehensive analysis of methods used for the evaluation of compounds against Mycobacterium tuberculosis.

I. Orme, T. Dick, S. Franzblau, 2012, Tuberculosis.

Structure-Activity Relationships of Spectinamide Antituberculosis Agents: A Dissection of Ribosomal Inhibition and Native Efflux Avoidance Contributions.

B. Meibohm, G. Robertson, A. Lenaerts, 2017, ACS infectious diseases.

Synthesis and evaluation of cyclic secondary amine substituted phenyl and benzyl nitrofuranyl amides as novel antituberculosis agents.

A. Lenaerts, Richard E. Lee, Robin E. B. Lee, 2005, Journal of medicinal chemistry.

Synthesis and evaluation of nitrofuranylamides as novel antituberculosis agents.

K. Hevener, S. Franzblau, A. Lenaerts, 2004, Journal of medicinal chemistry.

Rapid In Vivo Screening of Experimental Drugs for Tuberculosis Using Gamma Interferon Gene-Disrupted Mice

I. Orme, A. Lenaerts, V. Gruppo, 2003, Antimicrobial Agents and Chemotherapy.

Preclinical Testing of the Nitroimidazopyran PA-824 for Activity against Mycobacterium tuberculosis in a Series of In Vitro and In Vivo Models

Robert C. Reynolds, R. Reynolds, I. Orme, 2005, Antimicrobial Agents and Chemotherapy.

Limited Activity of Clofazimine as a Single Drug in a Mouse Model of Tuberculosis Exhibiting Caseous Necrotic Granulomas

M. Voskuil, R. Leistikow, A. Lenaerts, 2014, Antimicrobial Agents and Chemotherapy.

Spectinamides: A New Class of Semisynthetic Anti-Tuberculosis Agents that Overcome Native Drug Efflux

B. Meibohm, M. Gonzalez-Juarrero, A. Lenaerts, 2014, Nature Medicine.

INHIBITION OF MYCOLIC ACID TRANSPORT ACROSS THE MYCOBACTERIUM TUBERCULOSIS PLASMA MEMBRANE

Michael S. Scherman, Michael R. McNeil, Mary Jackson, 2011, Nature chemical biology.

Heterogeneity in tuberculosis pathology, microenvironments and therapeutic responses

C. Barry, A. Lenaerts, V. Dartois, 2015, Immunological reviews.

Glycolytic and Non-glycolytic Functions of Mycobacterium tuberculosis Fructose-1,6-bisphosphate Aldolase, an Essential Enzyme Produced by Replicating and Non-replicating Bacilli*

Jurgen Sygusch, Sabine Ehrt, Dirk Schnappinger, 2011, The Journal of Biological Chemistry.

Host Directed Therapy for Chronic Tuberculosis via Intrapulmonary Delivery of Aerosolized Peptide Inhibitors Targeting the IL-10-STAT3 Pathway

C. Wilusz, K. Stefanisko, N. Tarasova, 2018, Scientific Reports.

Spirocycle MmpL3 Inhibitors with Improved hERG and Cytotoxicity Profiles as Inhibitors of Mycobacterium tuberculosis Growth

A. Korkegian, L. Stojanovski, K. Read, 2021, ACS omega.

Menaquinone synthesis is critical for maintaining mycobacterial viability during exponential growth and recovery from non‐replicating persistence

J. C. Hinshaw, R. Slayden, D. Crick, 2009, Molecular microbiology.

Targeting Fatty Acid Biosynthesis for the Development of Novel Chemotherapeutics against Mycobacterium tuberculosis: Evaluation of A-Ring-Modified Diphenyl Ethers as High-Affinity InhA Inhibitors

Peter J. Tonge, Richard A. Slayden, P. Tonge, 2007, Antimicrobial Agents and Chemotherapy.

Location of Intra- and Extracellular M. tuberculosis Populations in Lungs of Mice and Guinea Pigs during Disease Progression and after Drug Treatment

R. Basaraba, A. Lenaerts, M. A. De Groote, 2011, PloS one.

Location of Persisting Mycobacteria in a Guinea Pig Model of Tuberculosis Revealed by R207910

S. Ehlers, I. Orme, R. Basaraba, 2007, Antimicrobial Agents and Chemotherapy.

Digital Image Analysis of Heterogeneous Tuberculosis Pulmonary Pathology in Non-Clinical Animal Models using Deep Convolutional Neural Networks

A. Ben-Hur, G. Robertson, B. Edwards, 2020, Scientific Reports.

Development of a Novel Lead that Targets M. tuberculosis Polyketide Synthase 13

Lisa K. Woolhiser, S. Norval, J. Sacchettini, 2017, Cell.

Evaluation of a Mouse Model of Necrotic Granuloma Formation Using C3HeB/FeJ Mice for Testing of Drugs against Mycobacterium tuberculosis

R. Basaraba, A. Lenaerts, I. Kramnik, 2012, Antimicrobial Agents and Chemotherapy.

Discovery of novel isoxazolines as anti-tuberculosis agents.

B. Meibohm, A. Lenaerts, Dianqing Sun, 2007, Bioorganic & medicinal chemistry letters.

Synthesis of new and potent analogues of anti-tuberculosis agent 5-nitro-furan-2-carboxylic acid 4-(4-benzyl-piperazin-1-yl)-benzylamide with improved bioavailability.

A. Lenaerts, Richard E. Lee, Robin E. B. Lee, 2006, Bioorganic & medicinal chemistry letters.

Nonclinical models for antituberculosis drug development: a landscape analysis.

K. Romero, A. Lenaerts, E. Nuermberger, 2015, The Journal of infectious diseases.

Discovery of Novel Oral Protein Synthesis Inhibitors of Mycobacterium tuberculosis That Target Leucyl-tRNA Synthetase

Christopher B. Cooper, Lisa K. Woolhiser, J. Sacchettini, 2016, Antimicrobial Agents and Chemotherapy.

Testing of Experimental Compounds in a Relapse Model of Tuberculosis Using Granulocyte-Macrophage Colony-Stimulating Factor Gene-Disrupted Mice

I. Orme, A. Lenaerts, L. Woolhiser, 2008, Antimicrobial Agents and Chemotherapy.

Antibiotic Bactericidal Activity Is Countered by Maintaining pH Homeostasis in Mycobacterium smegmatis

E. Clambey, M. Voskuil, R. Leistikow, 2016, mSphere.

Evaluation of Rifapentine in Long-Term Treatment Regimens for Tuberculosis in Mice

A. Lenaerts, M. Cynamon, S. Chase, 1999, Antimicrobial Agents and Chemotherapy.

Significant increases in the levels of liver enzymes in mice treated with anti-tuberculosis drugs.

I. Orme, A. Lenaerts, V. Gruppo, 2005, International journal of antimicrobial agents.

Model-Based Exposure-Response Assessment for Spectinamide 1810 in a Mouse Model of Tuberculosis

B. Meibohm, G. Robertson, A. Lenaerts, 2021, Antimicrobial agents and chemotherapy.

Torticollis in mice intravenously infected with Mycobacterium tuberculosis.

A. Lenaerts, E. Magden, J. Gilliland, 2011, Journal of the American Association for Laboratory Animal Science : JAALAS.

Evaluation of Standard Chemotherapy in the Guinea Pig Model of Tuberculosis

I. Orme, David F. Ackart, Laurel Hascall-Dove, 2010, Antimicrobial Agents and Chemotherapy.

Mycobacterium tuberculosis Lsr2 Is a Global Transcriptional Regulator Required for Adaptation to Changing Oxygen Levels and Virulence

Lisa K. Woolhiser, W. Jacobs, M. Voskuil, 2014, mBio.

Multiple M. tuberculosis Phenotypes in Mouse and Guinea Pig Lung Tissue Revealed by a Dual-Staining Approach

M. Voskuil, M. Gonzalez-Juarrero, R. Basaraba, 2010, PloS one.

Effects of P-MAPA Immunomodulator on Toll-Like Receptors and p53: Potential Therapeutic Strategies for Infectious Diseases and Cancer

A. Lenaerts, N. Durán, W. Fávaro, 2012, Infectious Agents and Cancer.

Improving acid-fast fluorescent staining for the detection of mycobacteria using a new nucleic acid staining approach.

H. Shapiro, A. Lenaerts, G. Ryan, 2014, Tuberculosis.

Discovery, synthesis, and biological evaluation of piperidinol analogs with anti-tuberculosis activity.

R. Slayden, A. Lenaerts, M. McNeil, 2009, Bioorganic & medicinal chemistry.

Metronidazole Lacks Antibacterial Activity in Guinea Pigs Infected with Mycobacterium tuberculosis

I. Orme, R. Basaraba, A. Lenaerts, 2008, Antimicrobial Agents and Chemotherapy.

Preclinical testing of new drugs for tuberculosis: current challenges.

I. Orme, A. Lenaerts, M. A. Degroote, 2008, Trends in microbiology.

Preclinical Evaluation of Inhalational Spectinamide-1599 Therapy against Tuberculosis.

B. Meibohm, M. Braunstein, C. Daley, 2021, ACS infectious diseases.

Comparative pharmacokinetics of spectinamide 1599 after subcutaneous and intrapulmonary aerosol administration in mice.

B. Meibohm, M. Braunstein, M. Gonzalez-Juarrero, 2019, Tuberculosis.

Spectinamides are effective partner agents for the treatment of tuberculosis in multiple mouse infection models

G. Robertson, A. Lenaerts, M. McNeil, 2016, The Journal of antimicrobial chemotherapy.

Visualization of Mycobacterial Biomarkers and Tuberculosis Drugs in Infected Tissue by MALDI-MS Imaging

Brendan Prideaux, Véronique Dartois, A. Lenaerts, 2018, Analytical chemistry.

Optimization of TAM16, a Benzofuran That Inhibits the Thioesterase Activity of Pks13; Evaluation toward a Preclinical Candidate for a Novel Antituberculosis Clinical Target

Robert H Bates, L. Stojanovski, K. Read, 2021, Journal of medicinal chemistry.

Efficacy and Improved Resistance Potential of a Cofactor-Independent InhA Inhibitor of Mycobacterium tuberculosis in the C3HeB/FeJ Mouse Model

A. Korkegian, G. Robertson, T. Parish, 2019, Antimicrobial Agents and Chemotherapy.

Discovery of a cofactor-independent inhibitor of Mycobacterium tuberculosis InhA

A. Korkegian, T. Ioerger, P. Tonge, 2018, Life Science Alliance.

Exposure to a Cutinase-like Serine Esterase Triggers Rapid Lysis of Multiple Mycobacterial Species*

L. Kremer, M. Gonzalez-Juarrero, D. Ke, 2012, The Journal of Biological Chemistry.

Novel pyridopyrazine and pyrimidothiazine derivatives as FtsZ inhibitors.

R. Reynolds, E. White, A. Lenaerts, 2011, Bioorganic & medicinal chemistry.

Nonclinical models for antituberculosis drug development: a landscape analysis.

K. Romero, A. Lenaerts, E. Nuermberger, 2015, The Journal of infectious diseases.

Mycobacterium tuberculosis precursor rRNA as a measure of treatment-shortening activity of drugs and regimens

B. D. de Jong, C. Wilusz, Benjamin Garcia, 2021, Nature Communications.

Evaluation of Moxifloxacin-Containing Regimens in Pathologically Distinct Murine Tuberculosis Models

A. Lenaerts, P. Converse, K. Mdluli, 2015, Antimicrobial Agents and Chemotherapy.

Isolation and purification of Mycobacterium tuberculosis from H37Rv infected guinea pig lungs.

J. Belisle, A. Izzo, D. Crick, 2014, Tuberculosis.

The DosR regulon of M. tuberculosis and antibacterial tolerance.

M. Voskuil, A. Lenaerts, M. Klein, 2009, Tuberculosis.

A microbiological assessment of novel nitrofuranylamides as anti-tuberculosis agents.

B. Meibohm, S. Franzblau, A. Lenaerts, 2008, The Journal of antimicrobial chemotherapy.

Drug distribution and efficacy of the DprE1 inhibitor BTZ-043 in the C3HeB/FeJ mouse tuberculosis model

M. Zimmerman, G. Robertson, A. Lenaerts, 2023, Antimicrobial agents and chemotherapy.

Preclinical testing of new drugs for tuberculosis: current challenges.

I. Orme, A. Lenaerts, M. A. Degroote, 2008, Trends in microbiology.

In vivo/in vitro pharmacokinetic and pharmacodynamic study of spray-dried poly-(dl-lactic-co-glycolic) acid nanoparticles encapsulating rifampicin and isoniazid.

A. Lenaerts, H. Swai, A. F. Kotzé, 2013, International journal of pharmaceutics.

Structure − Activity Relationships of Spectinamide Antituberculosis Agents : A Dissection of Ribosomal Inhibition and Native E ffl ux Avoidance Contributions

B. Meibohm, G. Robertson, A. Lenaerts, 2017 .

The Structure-Activity Relationships of Spectinamide Antituberculosis agents; a Dissection of Ribosomal Inhibition and Native Efflux Avoidance Contributions

B. Meibohm, G. Robertson, A. Lenaerts, 2017 .

GLYCOLYTIC AND NON-GLYCOLYTIC FUNCTIONS OF THE FRUCTOSE-1,6-BISPHOSPHATE ALDOLASE OF MYCOBACTERIUM TUBERCULOSIS , AN ESSENTIAL ENZYME PRODUCED BY REPLICATING AND NON-REPLICATING

D. Schnappinger, J. Sygusch, M. Gonzalez-Juarrero, 2011 .

Computational pharmacokinetics/pharmacodynamics of rifampin in a mouse tuberculosis infection model

Michael A. Lyons, A. Lenaerts, M. Lyons, 2015, Journal of Pharmacokinetics and Pharmacodynamics.