P. C. Fineran

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Global phylogeography and ancient evolution of the widespread human gut virus crAssphage

Alexander V. Tyakht, Samuel L. Díaz-Muñoz, Stan J. J. Brouns, 2019, Nature Microbiology.

Global phylogeography and ancient evolution of the widespread human gut virus crAssphage

Stan J. J. Brouns, Daniel A. Cuevas, Abigail E. Asangba, 2019, bioRxiv.

CRISPR–Cas systems: beyond adaptive immunity

Peter C. Fineran, A. Buckling, E. Westra, 2014, Nature Reviews Microbiology.

Biosynthesis of tripyrrole and β‐lactam secondary metabolites in Serratia: integration of quorum sensing with multiple new regulatory components in the control of prodigiosin and carbapenem antibiotic production

Peter C. Fineran, G. Salmond, H. Slater, 2005, Molecular microbiology.

The biosynthesis and regulation of bacterial prodiginines

Finian J. Leeper, Peter C. Fineran, G. Salmond, 2006, Nature Reviews Microbiology.

The phage abortive infection system, ToxIN, functions as a protein–RNA toxin–antitoxin pair

Kathryn S. Lilley, Peter C. Fineran, G. Salmond, 2009, Proceedings of the National Academy of Sciences.

Viral molecular mimicry circumvents abortive infection and suppresses bacterial suicide to make hosts permissive for replication

G. Salmond, P. C. Fineran, F. Short, 2012, Bacteriophage.

Ribonucleases in bacterial toxin-antitoxin systems.

V. Arcus, P. C. Fineran, G. Cook, 2013, Biochimica et biophysica acta.

Functional genomics reveals the toxin–antitoxin repertoire and AbiE activity in Serratia

P. C. Fineran, Simon A. Jackson, Hannah G. Hampton, 2020, Microbial genomics.

Mutagenesis and Functional Characterization of the RNA and Protein Components of the toxIN Abortive Infection and Toxin-Antitoxin Locus of Erwinia

G. Salmond, P. C. Fineran, I. Toth, 2009, Journal of bacteriology.

CRISPR-Cas gene-editing reveals RsmA and RsmC act through FlhDC to repress the SdhE flavinylation factor and control motility and prodigiosin production in Serratia

G. Salmond, M. Bostina, P. C. Fineran, 2016, Microbiology.

Phage-based biocontrol strategies and their application in agriculture and aquaculture.

Peter C. Fineran, P. C. Fineran, Luciano A. Rigano, 2018, Biochemical Society transactions.

Novel configurations of type I and II CRISPR-Cas systems in Corynebacterium diphtheriae.

P. Hoskisson, P. C. Fineran, V. Sangal, 2013, Microbiology.

Transposon insertion libraries for the characterization of mutants from the kiwifruit pathogen Pseudomonas syringae pv. actinidiae

P. Gardner, M. Templeton, C. Mesarich, 2017, PloS one.

Regulation of CRISPR-Cas adaptive immune systems.

P. C. Fineran, A. Patterson, Mariya S Yevstigneyeva, 2017, Current opinion in microbiology.

Bioinformatic evidence of widespread priming in type I and II CRISPR-Cas systems

Chris M. Brown, Peter C. Fineran, R. Staals, 2018, RNA biology.

Interference-driven spacer acquisition is dominant over naive and primed adaptation in a native CRISPR–Cas system

Chris M. Brown, Stan J. J. Brouns, Peter C. Fineran, 2016, Nature Communications.

Advances in Bacteriophage-Mediated Control of Plant Pathogens

Peter C. Fineran, P. C. Fineran, R. Frampton, 2012, International journal of microbiology.

Discovery of multiple anti-CRISPRs highlights anti-defense gene clustering in mobile genetic elements

Chris M. Brown, S. Sørensen, J. Bondy-Denomy, 2020, Nature Communications.

Discovery of multiple anti-CRISPRs uncovers anti-defense gene clustering in mobile genetic elements

Chris M. Brown, S. Sørensen, J. Bondy-Denomy, 2020, bioRxiv.

Resistance is not futile: bacterial 'innate' and CRISPR-Cas 'adaptive' immune systems.

P. C. Fineran, P. Fineran, 2019, Microbiology.

Bacterial dormancy curbs phage epidemics

P. C. Fineran, Simon A. Jackson, 2019, Nature.

Complete DNA Sequence of Pseudomonas syringae pv. actinidiae, the Causal Agent of Kiwifruit Canker Disease

M. Templeton, P. C. Fineran, E. Rikkerink, 2015, Genome Announcements.

Genome, Proteome and Structure of a T7-Like Bacteriophage of the Kiwifruit Canker Phytopathogen Pseudomonas syringae pv. actinidiae

V. Young, M. Bostina, P. C. Fineran, 2015, Viruses.

Anticancer and immunosuppressive properties of bacterial prodiginines.

Peter C. Fineran, G. Salmond, P. C. Fineran, 2007, Future microbiology.

Type III CRISPR–Cas provides resistance against nucleus-forming jumbo phages via abortive infection

Peter C. Fineran, P. C. Fineran, Simon A. Jackson, 2022, bioRxiv.

A Unified Resource for Tracking Anti-CRISPR Names.

J. Doudna, A. Davidson, B. Wiedenheft, 2018, The CRISPR journal.

CRISPR-Cas-Mediated Phage Resistance Enhances Horizontal Gene Transfer by Transduction

R. Staals, P. C. Fineran, B. N. Watson, 2018, mBio.

The subtype I-F CRISPR-Cas system influences pathogenicity island retention in Pectobacterium atrosepticum via crRNA generation and Csy complex formation.

P. C. Fineran, Corinna Richter, 2013, Biochemical Society transactions.

Structural rearrangements allow nucleic acid discrimination by type I-D Cascade

David W. Taylor, D. Wrapp, E. Schwartz, 2022, Nature Communications.

Targeting of temperate phages drives loss of type I CRISPR-Cas systems

Peter C. Fineran, S. Gandon, E. Westra, 2019, Nature.

Type I-F CRISPR-Cas resistance against virulent phages results in abortive infection and provides population-level immunity

G. Salmond, E. Westra, R. Staals, 2019, Nature Communications.

Type I-F CRISPR-Cas resistance against virulent phage infection triggers abortive infection and provides population-level immunity

G. Salmond, E. Westra, R. Staals, 2019, bioRxiv.

Imprecise Spacer Acquisition Generates CRISPR-Cas Immune Diversity through Primed Adaptation.

Peter C. Fineran, P. C. Fineran, Simon A. Jackson, 2019, Cell host & microbe.

Genome-wide correlation analysis suggests different roles of CRISPR-Cas systems in the acquisition of antibiotic resistance genes in diverse species

Chris M. Brown, P. C. Fineran, T. Chyou, 2019, Philosophical Transactions of the Royal Society B.

Molecular basis of anti-CRISPR operon repression by Aca10

H. H. Park, P. C. Fineran, So-Yeon Lee, 2022, Nucleic acids research.

Molecular basis of dual anti-CRISPR and auto-regulatory functions of AcrIF24

H. H. Park, Y. Kim, P. C. Fineran, 2022, Nucleic acids research.

Approaches for bacteriophage genome engineering.

Sam P. B. van Beljouw, Stan J. J. Brouns, A. R. Costa, 2022, Trends in biotechnology.

Assembly of multi-subunit fusion proteins into the RNA-targeting type III-D CRISPR-Cas effector complex

Caitlyn L. McCafferty, J. Brodbelt, E. Schwartz, 2022, bioRxiv.

Conquering CRISPR: how phages overcome bacterial adaptive immunity.

P. C. Fineran, Lucia M Malone, N. Birkholz, 2020, Current opinion in biotechnology.

A jumbo phage that forms a nucleus-like structure evades CRISPR–Cas DNA targeting but is vulnerable to type III RNA-based immunity

P. Gardner, P. C. Fineran, Simon A. Jackson, 2019, Nature Microbiology.

A nucleus-forming jumbophage evades CRISPR-Cas DNA targeting but is vulnerable to type III RNA-based immunity

P. Gardner, P. C. Fineran, Simon A. Jackson, 2019, bioRxiv.

The autoregulator Aca2 mediates anti-CRISPR repression

P. C. Fineran, Simon A. Jackson, Robert D. Fagerlund, 2019, Nucleic acids research.

Computational Detection of CRISPR/crRNA Targets.

Chris M. Brown, P. C. Fineran, A. Biswas, 2015, Methods in molecular biology.

Antitoxin autoregulation of M. tuberculosis toxin-antitoxin expression through negative cooperativity arising from multiple inverted repeat sequences

Peter C. Fineran, P. C. Fineran, T. R. Blower, 2020, The Biochemical journal.

Widespread repression of anti-CRISPR production by anti-CRISPR-associated proteins

P. C. Fineran, Saadlee Shehreen, Chris M Brown, 2022, Nucleic acids research.

Bacterial defense islands limit viral attack

Peter C. Fineran, P. C. Fineran, S. Meaden, 2021, Science.

Type I CRISPR-Cas provides robust immunity but incomplete attenuation of phage-induced cellular stress

X. Morgan, P. C. Fineran, Hannah G. Hampton, 2021, Nucleic acids research.

A lipopolysaccharide‐dependent phage infects a pseudomonad phytopathogen and can evolve to evade phage resistance

M. Templeton, M. Bostina, P. C. Fineran, 2022, bioRxiv.

A nucleotidyltransferase toxin inhibits growth of Mycobacterium tuberculosis through inactivation of tRNA acceptor stems

C. Condon, O. Neyrolles, P. Genevaux, 2020, Science Advances.

Bacteriophage ΦM1 of Pectobacterium evolves to escape two bifunctional Type III 1 toxin-antitoxin and abortive infection systems through mutations in a single viral 2 gene 3

G. Salmond, B. Luisi, P. C. Fineran, 2020 .

Evolution of Pectobacterium Bacteriophage ΦM1 To Escape Two Bifunctional Type III Toxin-Antitoxin and Abortive Infection Systems through Mutations in a Single Viral Gene

G. Salmond, B. Luisi, P. C. Fineran, 2017, Applied and Environmental Microbiology.

A GntR family transcriptional regulator (PigT) controls gluconate-mediated repression and defines a new, independent pathway for regulation of the tripyrrole antibiotic, prodigiosin, in Serratia.

G. Salmond, H. Slater, P. C. Fineran, 2005, Microbiology.

CRISPR–Cas impedes archaeal mating

P. C. Fineran, 2018, Nature Microbiology.

Viral Evasion of a Bacterial Suicide System by RNA–Based Molecular Mimicry Enables Infectious Altruism

G. Salmond, P. C. Fineran, R. Przybilski, 2012, PLoS genetics.

Prokaryotic assembly factors for the attachment of flavin to complex II.

Peter C. Fineran, P. C. Fineran, Matthew B. McNeil, 2013, Biochimica et biophysica acta.

A widespread bacteriophage abortive infection system functions through a Type IV toxin–antitoxin mechanism

G. Salmond, P. C. Fineran, R. Przybilski, 2014, Nucleic acids research.

PigZ, a TetR/AcrR family repressor, modulates secondary metabolism via the expression of a putative four‐component resistance‐nodulation‐cell‐division efflux pump, ZrpADBC, in Serratia sp. ATCC 39006

G. Salmond, P. C. Fineran, L. Everson, 2008, Molecular microbiology.

Inactivation of CRISPR-Cas systems by anti-CRISPR proteins in diverse bacterial species

Peter C. Fineran, Alan R Davidson, A. Davidson, 2016, Nature Microbiology.

The PhoBR two-component system regulates antibiotic biosynthesis in Serratia in response to phosphate

G. Salmond, P. C. Fineran, L. Everson, 2009, BMC Microbiology.

Variation at the common polysaccharide antigen locus drives lipopolysaccharide diversity within the Pseudomonas syringae species complex

M. Templeton, C. Mesarich, P. C. Fineran, 2020, Environmental microbiology.

Variation at the common polysaccharide antigen locus drives lipopolysaccharide diversity within the P. syringae species complex

M. Templeton, C. Mesarich, P. C. Fineran, 2020, bioRxiv.

Diverse CRISPR-Cas Complexes Require Independent Translation of Small and Large Subunits from a Single Gene.

David W. Taylor, E. Schwartz, P. C. Fineran, 2020, Molecular cell.

Diverse CRISPR-Cas complexes require independent translation of small and large subunits from a single gene

David W. Taylor, E. Schwartz, P. C. Fineran, 2020, bioRxiv.

CRISPR-Cas systems are widespread accessory elements across bacterial and archaeal plasmids

Shiraz A. Shah, S. Sørensen, R. Garrett, 2021, bioRxiv.

Spacer capture and integration by a type I-F Cas1–Cas2-3 CRISPR adaptation complex

A. Heck, R. Scheltema, R. Staals, 2017, Proceedings of the National Academy of Sciences.

Memory of viral infections by CRISPR-Cas adaptive immune systems: acquisition of new information.

Emmanuelle Charpentier, E. Charpentier, P. C. Fineran, 2012, Virology.

Chromosomal targeting by CRISPR-Cas systems can contribute to genome plasticity in bacteria

P. C. Fineran, A. Pitman, Ron L. Dy, 2013, Mobile genetic elements.

Cytotoxic Chromosomal Targeting by CRISPR/Cas Systems Can Reshape Bacterial Genomes and Expel or Remodel Pathogenicity Islands

Peter C. Fineran, P. C. Fineran, R. Przybilski, 2013, PLoS genetics.

The arms race between bacteria and their phage foes

Peter C. Fineran, P. C. Fineran, Hannah G. Hampton, 2020, Nature.

Type III CRISPR-Cas systems can provide redundancy to counteract viral escape from type I systems

Peter C. Fineran, A. Fire, P. C. Fineran, 2017, eLife.

CRISPRDetect: A flexible algorithm to define CRISPR arrays

Chris M. Brown, Ambarish Biswas, Peter C. Fineran, 2016, BMC Genomics.

The Cpf1 CRISPR-Cas protein expands genome-editing tools

Peter C. Fineran, R. Staals, P. C. Fineran, 2015, Genome Biology.

A century of the phage: past, present and future

Peter C. Fineran, G. Salmond, P. C. Fineran, 2015, Nature Reviews Microbiology.

GalK limits type I-F CRISPR-Cas expression in a CRP-dependent manner.

P. C. Fineran, Hannah G. Hampton, Corinda Taylor, 2019, FEMS microbiology letters.

CRISPR-Cas: Adapting to change

Stan J. J. Brouns, Peter C. Fineran, Rebecca E. McKenzie, 2017, Science.

Quorum Sensing Controls Adaptive Immunity through the Regulation of Multiple CRISPR-Cas Systems

G. Evans, G. Salmond, R. Staals, 2016, Molecular cell.

Regulation of the Type I-F CRISPR-Cas system by CRP-cAMP and GalM controls spacer acquisition and interference

P. C. Fineran, Corinda Taylor, A. Patterson, 2015, Nucleic acids research.

Priming in the Type I-F CRISPR-Cas system triggers strand-independent spacer acquisition, bi-directionally from the primed protospacer

Peter C. Fineran, Rebecca E. McKenzie, R. Staals, 2014, Nucleic acids research.

In Vivo Protein Interactions and Complex Formation in the Pectobacterium atrosepticum Subtype I-F CRISPR/Cas System

Peter C. Fineran, P. C. Fineran, Corinna Richter, 2012, PloS one.

Virulence and Prodigiosin Antibiotic Biosynthesis in Serratia Are Regulated Pleiotropically by the GGDEF/EAL Domain Protein, PigX

G. Salmond, K. Lilley, P. C. Fineran, 2007, Journal of bacteriology.

Complete Genome Sequences of the Escherichia coli Donor Strains ST18 and MFDpir

P. C. Fineran, Simon A. Jackson, Bridget J Fellows, 2020, Microbiology Resource Announcements.

Selectivity and self-assembly in the control of a bacterial toxin by an antitoxic noncoding RNA pseudoknot

Peter C. Fineran, G. Salmond, X. Pei, 2012, Proceedings of the National Academy of Sciences.

Biotechnological exploitation of bacteriophage research.

Peter C. Fineran, Nicola K. Petty, G. Salmond, 2007, Trends in biotechnology.

CRISPRDetect: A flexible algorithm to define CRISPR arrays

Chris M. Brown, S. Morales, R. Staals, 2016, BMC Genomics.

Degenerate target sites mediate rapid primed CRISPR adaptation

Jos Boekhorst, Stan J. J. Brouns, Peter C. Fineran, 2014, Proceedings of the National Academy of Sciences.

The arms race between bacteria and their phage foes

P. C. Fineran, Hannah G. Hampton, B. N. Watson, 2020, Nature.

PADLOC: a web server for the identification of antiviral defence systems in microbial genomes

P. C. Fineran, N. Toro, Simon A. Jackson, 2022, Nucleic Acids Res..

CRISPRTarget: bioinformatic prediction and analysis of crRNA targets.

Chris M. Brown, Ambarish Biswas, Stan J. J. Brouns, 2013, RNA biology.

CRISPR-Cas systems preferentially target the leading regions of MOBF conjugative plasmids

Sarah Neumann, Fernando de la Cruz, Stan J. J. Brouns, 2013, RNA biology.

Turning down the (C)BASS: Phage-encoded inhibitors jam bacterial immune signaling.

P. C. Fineran, N. Birkholz, 2022, Molecular cell.

Identification and classification of antiviral defence systems in bacteria and archaea with PADLOC reveals new system types

Franklin L. Nobrega, C. Ronson, P. C. Fineran, 2021, Nucleic acids research.

Different genetic and morphological outcomes for phages targeted by single or multiple CRISPR-Cas spacers

G. Salmond, R. Staals, M. Bostina, 2019, Philosophical Transactions of the Royal Society B.

Function and Regulation of Clustered Regularly Interspaced Short Palindromic Repeats (CRISPR) / CRISPR Associated (Cas) Systems

Peter C. Fineran, P. C. Fineran, Corinna Richter, 2012, Viruses.

Remarkable Mechanisms in Microbes to Resist Phage Infections.

Peter C. Fineran, G. Salmond, P. C. Fineran, 2014, Annual review of virology.

Phage ΦPan70, a Putative Temperate Phage, Controls Pseudomonas aeruginosa in Planktonic, Biofilm and Burn Mouse Model Assays

P. C. Fineran, E. Kutter, Corinda Taylor, 2015, Viruses.

Csy4 is responsible for CRISPR RNA processing in Pectobacterium atrosepticum

Peter C. Fineran, P. C. Fineran, R. Przybilski, 2011, RNA biology.

A processed noncoding RNA regulates an altruistic bacterial antiviral system

Peter C. Fineran, G. Salmond, X. Pei, 2011, Nature Structural &Molecular Biology.

Phage capsid recognition triggers activation of a bacterial toxin-antitoxin defense system.

P. C. Fineran, Leah M. Smith, 2023, Molecules and Cells.

Identification of Bacteriophages for Biocontrol of the Kiwifruit Canker Phytopathogen Pseudomonas syringae pv. actinidiae

Nicola K. Petty, P. C. Fineran, R. Frampton, 2014, Applied and Environmental Microbiology.

Integrated regulation involving quorum sensing, a two-component system, a GGDEF/EAL domain protein and a post-transcriptional regulator controls swarming and RhlA-dependent surfactant biosynthesis in Serratia.

Peter C. Fineran, G. Salmond, P. C. Fineran, 2008, Environmental microbiology.

The Rsm (Csr) post-transcriptional regulatory pathway coordinately controls multiple CRISPR–Cas immune systems

C. Sharma, T. Bischler, P. C. Fineran, 2021, Nucleic acids research.

The Rcs stress response inversely controls surface and CRISPR–Cas adaptive immunity to discriminate plasmids and phages

P. Gardner, P. C. Fineran, Simon A. Jackson, 2021, Nature Microbiology.

Draft Genome Sequence of Serratia sp. Strain ATCC 39006, a Model Bacterium for Analysis of the Biosynthesis and Regulation of Prodigiosin, a Carbapenem, and Gas Vesicles

G. Salmond, J. L. Stanton, K. Brügger, 2013, Genome Announcements.

PigS and PigP Regulate Prodigiosin Biosynthesis in Serratia via Differential Control of Divergent Operons, Which Include Predicted Transporters of Sulfur-Containing Molecules

G. Salmond, P. C. Fineran, Matthew B. McNeil, 2010, Journal of bacteriology.

Diverse CRISPR-Cas complexes require independent translation of small and large subunits from a single gene

David W. Taylor, E. Schwartz, P. C. Fineran, 2020, bioRxiv.

Structural plasticity and in vivo activity of Cas1 from the type I-F CRISPR-Cas system.

Rebecca E. McKenzie, R. Staals, P. C. Fineran, 2016, The Biochemical journal.

Genome Sequence of a Jumbo Bacteriophage That Infects the Kiwifruit Phytopathogen Pseudomonas syringae pv. actinidiae

P. C. Fineran, H. Hendrickson, R. Frampton, 2019, Microbiology Resource Announcements.

A mobile restriction–modification system provides phage defence and resolves an epigenetic conflict with an antagonistic endonuclease

P. C. Fineran, Simon A. Jackson, Robert D. Fagerlund, 2022, Nucleic acids research.

Identification and classification of bacterial Type III toxin–antitoxin systems encoded in chromosomal and plasmid genomes

Peter C. Fineran, K. Mizuguchi, G. Salmond, 2012, Nucleic acids research.

Evolution of virulence in a novel family of transmissible mega-plasmids.

M. Cox, P. Gardner, T. Glare, 2021, Environmental microbiology.

SorTn-seq: a high-throughput functional genomics approach to discovering regulators of bacterial gene expression

P. Gardner, P. C. Fineran, Simon A. Jackson, 2021, Nature Protocols.

High viral abundance and low diversity are associated with increased CRISPR-Cas prevalence across microbial ecosystems

B. Dutilh, E. Westra, S. Morales, 2021, Current Biology.

The conserved RGxxE motif of the bacterial FAD assembly factor SdhE is required for succinate dehydrogenase flavinylation and activity.

P. C. Fineran, Matthew B. McNeil, P. Fineran, 2013, Biochemistry.

Pectobacterium atrosepticum and Pectobacterium carotovorum Harbor Distinct, Independently Acquired Integrative and Conjugative Elements Encoding Coronafacic Acid that Enhance Virulence on Potato Stems

Peter C. Fineran, M. Fiers, C. Ronson, 2016, Front. Microbiol..

YgfX (CptA) is a multimeric membrane protein that interacts with the succinate dehydrogenase assembly factor SdhE (YgfY).

Peter C. Fineran, P. C. Fineran, Matthew B. McNeil, 2013, Microbiology.