A. Chan

发表

Protein tyrosine phosphatase non-receptor type 22 modulates colitis in a microbiota-dependent manner.

C. von Mering, G. Rogler, D. Rawlings, 2019, The Journal of clinical investigation.

T Cell Receptor Signaling Precedes Immunological Synapse Formation

Michael Loran Dustin, P. Allen, A. Shaw, 2002, Science.

Recurrent viral infections associated with a homozygous CORO1A mutation that disrupts oligomerization and cytoskeletal association.

Toshiro K. Ohsumi, R. Geha, J. Chou, 2016, The Journal of allergy and clinical immunology.

Requirement for Coronin 1 in T Lymphocyte Trafficking and Cellular Homeostasis

D. Danilenko, L. Rangell, A. Chan, 2006, Science.

Importance of Cellular Microenvironment and Circulatory Dynamics in B Cell Immunotherapy1

L. Diehl, Yanmei Lu, Y. Meng, 2005, The Journal of Immunology.

An essential role for BLNK in human B cell development.

D. Campana, E. Coustan-Smith, M. Conley, 1999, Science.

Therapeutic antibodies for autoimmunity and inflammation

Andrew C. Chan, P. Carter, A. Chan, 2010, Nature Reviews Immunology.

Regulation of T Cell Receptor Signaling by DENND1B in TH2 Cells and Allergic Disease

Arthur Wuster, Meijuan Zhou, Andrew C. Chan, 2016, Cell.

ZAP-70: A 70 kd protein-tyrosine kinase that associates with the TCR ζ chain

Arthur Weiss, Christoph W. Turck, Andrew C. Chan, 1992, Cell.

Direct Regulation of ZAP-70 by SHP-1 in T Cell Antigen Receptor Signaling

D. Plas, A. Chan, Matthew L. Thomas, 1996, Science.

The role of receptor internalization in CD95 signaling

C. Hallas, M. Peter, A. Chan, 2006, The EMBO journal.

Discovery of a novel series of inhibitors of lymphoid tyrosine phosphatase with activity in human T cells.

Nunzio Bottini, Sheng Li, Tong Liu, 2011, Journal of medicinal chemistry.

B cell immunobiology in disease: evolving concepts from the clinic.

A. Chan, F. Martin, 2006, Annual review of immunology.

Molecular cloning of human Syk. A B cell protein-tyrosine kinase associated with the surface immunoglobulin M-B cell receptor complex.

C. Disteche, S. Edelhoff, A. Weiss, 1994, The Journal of biological chemistry.

Essential role for ZAP-70 in both positive and negative selection of thymocytes

K. Nakayama, K. Nakayama, D. Loh, 1995, Nature.

Signaling Takes Shape in Review the Immune System

Michael Loran Dustin, A. Chan, 2000 .

Binding of ZAP-70 to phosphorylated T-cell receptor zeta and eta enhances its autophosphorylation and generates specific binding sites for SH2 domain-containing proteins

A. Shaw, A. Chan, C. Terhorst, 1995, Molecular and cellular biology.

New insights into T-cell antigen receptor structure and signal transduction.

A. Chan, B. Irving, A. Weiss, 1992, Current opinion in immunology.

The role of protein tyrosine kinases and protein tyrosine phosphatases in T cell antigen receptor signal transduction.

A. Weiss, A. Chan, D. Desai, 1994, Annual review of immunology.

Surface receptor Toso controls B cell–mediated regulation of T cell immunity

K. Brand, A. Chan, A. Westphal, 2018, The Journal of clinical investigation.

Accumulation of 4-1BBL+ B cells in the elderly induces the generation of granzyme-B+ CD8+ T cells with potential antitumor activity.

L. Ferrucci, M. Croft, J. Mattison, 2014, Blood.

Haploinsufficiency of B cell linker protein enhances B cell signaling defects in mice expressing a limiting dosage of Bruton's tyrosine kinase.

A. Satterthwaite, O. Witte, A. Chan, 2003, International immunology.

Requirement for B cell linker protein (BLNK) in B cell development.

A. Cheng, A. Chan, C. Chiu, 1999, Science.

Protein tyrosine kinases in thymocyte development.

A. Cheng, A. Chan, 1997, Current opinion in immunology.

Restoration of thymocyte development and function in zap-70-/- mice by the Syk protein tyrosine kinase.

A. Chan, I. Negishi, Q. Gong, 1997, Immunity.

The Syk and ZAP-70 SH2-containing tyrosine kinases are implicated in pre-T cell receptor signaling.

T. Pawson, D. Loh, A. Cheng, 1997, Proceedings of the National Academy of Sciences of the United States of America.

Identification of Two Tyrosine Phosphoproteins, pp70 and pp68, Which Interact with Phospholipase Cγ, Grb2, and Vav after B Cell Antigen Receptor Activation*

A. Chan, C. Fu, 1997, The Journal of Biological Chemistry.

Regulation of antigen receptor signal transduction by protein tyrosine kinases.

A. Shaw, A. Chan, 1996, Current opinion in immunology.

ZAP-70 deficiency in an autosomal recessive form of severe combined immunodeficiency.

W. Kuo, A. Weiss, T. Parslow, 1994, Science.

Differential expression of ZAP-70 and Syk protein tyrosine kinases, and the role of this family of protein tyrosine kinases in TCR signaling.

A. Weiss, L. Turka, E. Clark, 1994, Journal of immunology.

Subcellular compartmentalization of FADD as a new level of regulation in death receptor signaling

A. Chan, N. Föger, Kyeong-Hee Lee, 2009, The FEBS journal.

Oligosaccharide structure of human C4.

J. Atkinson, A. Chan, 1985, Journal of immunology.

A golden era of opportunity in immunotherapy discovery and development

A. Chan, Andrew C. Chan, 2008, Immunological reviews.

Expression of dominant-negative src-homology domain 2-containing protein tyrosine phosphatase-1 results in increased Syk tyrosine kinase activity and B cell activation.

D. Plas, A. Chan, M. Thomas, 1999, Journal of immunology.

Activation Syk Tyrosine Kinase Activity and B Cell Tyrosine Phosphatase-1 Results in Increased Src-Homology Domain 2-Containing Protein Expression of Dominant-Negative

D. Plas, Yonghong Hu, A. Chan, 1999 .

B cell immunotherapy in autoimmunity--2010 update.

A. Chan, 2011, Molecular immunology.

THE ROLE OF PROTEIN TYROSINE KINASES AND PROTEIN TYROSINE PHOSPHATASES IN T CELL ANTIGEN RECEPTOR

A. Weiss, A. Chan, D. Desai, 1994 .

Transient B-Cell Depletion with Anti-CD20 in Combination with Proinsulin DNA Vaccine or Oral Insulin: Immunologic Effects and Efficacy in NOD Mice

H. Garren, L. Steinman, M. Atkinson, 2013, PloS one.

Membrane Cofactor Protein (MCP; CD46): Isoform-Specific Tyrosine Phosphorylation1

J. Atkinson, A. Chan, M. Liszewski, 2000, The Journal of Immunology.

Inefficient ZAP-70 Phosphorylation and Decreased Thymic Selection In Vivo Result from Inhibition of NF-κB/Rel1

M. Boothby, A. Chan, A. Mora, 2001, The Journal of Immunology.

Functional Complementation of BLNK by SLP-76 and LAT Linker Proteins*

T. Kurosaki, A. Chan, M. Ishiai, 2000, The Journal of Biological Chemistry.

Involvement of Lat, Gads, and Grb2 in Compartmentation of Slp-76 to the Plasma Membrane

K. Sugamura, T. Kurosaki, A. Chan, 2000, The Journal of experimental medicine.

Adapter proteins SLP-76 and BLNK both are expressed by murine macrophages and are linked to signaling via Fcgamma receptors I and II/III.

R. Geha, F. Bonilla, A. Chan, 2000, Proceedings of the National Academy of Sciences of the United States of America.

CHAPTER 80 – Non-Receptor Protein Tyrosine Kinases in T-Cell Antigen Receptor Function

A. Chan, Shin-Won Kang, K. Hasegawa, 2003 .

Molecular and Genetic Insights into T‐Cell Antigen Receptor Signaling

A. Weiss, A. Chan, T. Kadlecek, 1995, Annals of the New York Academy of Sciences.

Molecular and genetic insights into T cell antigen receptor signal transduction.

A. Weiss, A. Chan, T. Kadlecek, 1994, Advances in experimental medicine and biology.

B cell-mediated regulatory mechanisms control tumor-promoting intestinal inflammation.

K. Brand, A. Chan, T. Strowig, 2022, Cell reports.

BLNK required for coupling Syk to PLC gamma 2 and Rac1-JNK in B cells.

T. Kurosaki, A. Iwamatsu, K. Okawa, 1999, Immunity.

The 20 faces of the fourth component of complement.

D. Karp, J. Atkinson, A. Chan, 1984, Immunology today.

Isoform-Specific Tyrosine Phosphorylation Membrane Cofactor Protein (MCP; CD46):

J. Atkinson, A. Chan, M. Liszewski, 2017 .

Implications for Tolerance and Activation Receptor in Mature and Immature B Cells: Unique Signaling Properties of B Cell Antigen

A. Chan, R. Benschop, C. Cambier, 2001 .

Ocrelizumab: A New Therapeutic Paradigm for Multiple SclerosisPublished as part of the Biochemistry series "Biochemistry to Bedside".

A. Chan, P. Chin, 2017, Biochemistry.

Faculty Opinions recommendation of The N-terminal SH4 region of the Src family kinase Fyn is modified by methylation and heterogeneous fatty acylation: role in membrane targeting, cell adhesion, and spreading.

A. Chan, 2004 .

Sequence analysis of the COOH terminus of the alpha-chain of the fourth component of human complement. Identification of the site of its extracellular cleavage.

G. Hortin, J. Atkinson, A. Chan, 1986, The Journal of biological chemistry.

Complement and the Rheumatic Diseases

J. Atkinson, V. Holers, A. Chan, 1986 .

Identification and structural characterization of two incompletely processed forms of the fourth component of human complement.

J. Atkinson, A. Chan, John P. Atkinson, 1983, The Journal of clinical investigation.

Identification and partial characterization of the secreted form of the fourth component of human complement: evidence that it is different from major plasma form.

D. Karp, J. Atkinson, K. Mitchell, 1983, Proceedings of the National Academy of Sciences of the United States of America.

Toso regulates the balance between apoptotic and nonapoptotic death receptor signaling by facilitating RIP1 ubiquitination.

T. Mak, X. Nguyen, M. A. Kamal, 2011, Blood.

B‐cell targeted therapies in human autoimmune diseases: an updated perspective

J. Monroe, A. Chan, M. Townsend, 2010, Immunological reviews.

Human severe combined immunodeficiency due to a defect in ZAP-70, a T cell tyrosine kinase.

T. Hope, A. Weiss, T. Parslow, 1994, Science.

Differential regulation of mast cell degranulation versus cytokine secretion by the actin regulatory proteins Coronin1a and Coronin1b

A. Chan, N. Föger, Kyeong-Hee Lee, 2011, The Journal of experimental medicine.

Analysis of the interaction of ZAP-70 and syk protein-tyrosine kinases with the T-cell antigen receptor by plasmon resonance.

A. Shaw, A. Chan, A S Shaw, 1995, Proceedings of the National Academy of Sciences of the United States of America.

ZAP-70: a 70 kd protein-tyrosine kinase that associates with the TCR zeta chain.

C W Turck, C. Turck, A. Weiss, 1992, Cell.

A Specificity Map for the PDZ Domain Family

Chris Sander, Gary D Bader, Somasekar Seshagiri, 2008, PLoS biology.

Regulation of a Late Phase of T Cell Polarity and Effector Functions by Crtam

S. Sidhu, A. Chan, J. Yeh, 2008, Cell.

Sequential interactions of the TCR with two distinct cytoplasmic tyrosine kinases.

A. Weiss, A. Chan, B. Irving, 1994, Science.

PTPN22 regulates NLRP3-mediated IL1B secretion in an autophagy-dependent manner

G. Rogler, D. Rawlings, M. Spalinger, 2017, Autophagy.

NLRP 3 tyrosine phosphorylation is controlled by protein tyrosine phosphatase PTPN 22

B. Becher, G. Rogler, S. Vavricka, 2018 .

NLRP3 tyrosine phosphorylation is controlled by protein tyrosine phosphatase PTPN22.

B. Becher, G. Rogler, S. Vavricka, 2016, The Journal of clinical investigation.

Activation of human CD4+ cells with CD3 and CD46 induces a T-regulatory cell 1 phenotype

K. Murphy, J. Atkinson, A. Chan, 2003, Nature.

BLNK: a central linker protein in B cell activation.

C. Turck, T. Kurosaki, A. Chan, 1998, Immunity.

Requirement for Tyrosine Residues 315 and 319 within ζ Chain–Associated Protein 70 for T Cell Development

A. Chan, A. Akk, Q. Gong, 2001, The Journal of experimental medicine.

Phosphorylation of Tyr319 in ZAP‐70 is required for T‐cell antigen receptor‐dependent phospholipase C‐γ1 and Ras activation

R. Abraham, C. C. Chini, A. Chan, 1999, The EMBO journal.

Activation of ZAP‐70 kinase activity by phosphorylation of tyrosine 493 is required for lymphocyte antigen receptor function.

R. Johnson, R. Thoma, T. Kurosaki, 1995, The EMBO journal.

Signaling Takes Shape in the Immune System

Michael Loran Dustin, A. Chan, 2000, Cell.

The zeta chain is associated with a tyrosine kinase and upon T-cell antigen receptor stimulation associates with ZAP-70, a 70-kDa tyrosine phosphoprotein.

Arthur Weiss, Andrew C. Chan, A. Chan, 1991, Proceedings of the National Academy of Sciences of the United States of America.

Rituximab’s New Therapeutic Target: The Podocyte Actin Cytoskeleton

A. Chan, 2011, Science Translational Medicine.

Pathogenic roles of B cells in human autoimmunity; insights from the clinic.

A. Chan, F. Martin, 2004, Immunity.

Reconstitution of Syk function by the ZAP-70 protein tyrosine kinase.

T. Kurosaki, A. Shaw, A. Chan, 1995, Immunity.

The Direct Recruitment of BLNK to Immunoglobulin α Couples the B-Cell Antigen Receptor to Distal Signaling Pathways

R. Aebersold, M. Gold, M. Affolter, 2002, Molecular and Cellular Biology.

Genetic Evidence of a Role for Lck in T-Cell Receptor Function Independent or Downstream of ZAP-70/Syk Protein Tyrosine Kinases

A. Chan, J. Wong, D. Straus, 1998, Molecular and Cellular Biology.

Regulation of B cell function by linker proteins.

A. Chan, M. E. Kelly, 2000, Current opinion in immunology.

Regulation of antigen receptor function by protein tyrosine kinases.

G. Waksman, K. Fütterer, A. Chan, 1999, Progress in biophysics and molecular biology.

Regulation of PAK activation and the T cell cytoskeleton by the linker protein SLP-76.

B. Mayer, J. Chernoff, J. Chernoff, 1998, Immunity.

Distinct tyrosine phosphorylation sites in ZAP-70 mediate activation and negative regulation of antigen receptor function

T. Kurosaki, A. Chan, D. Straus, 1996, Molecular and cellular biology.

Immune System Dysfunction and Autoimmune Disease in Mice Lacking Emk (Par-1) Protein Kinase

H. Piwnica-Worms, K. Murphy, C. Zmasek, 2001, Molecular and Cellular Biology.

In Search of Magic Bullets: The Golden Age of Immunotherapeutics

J. O’Shea, Y. Kanno, A. Chan, 2014, Cell.

Epstein-Barr Virus Latent Membrane Protein 2a (Lmp2a) Employs the Slp-65 Signaling Module

R. Longnecker, M. Merchant, A. Chan, 2001, The Journal of experimental medicine.

The autoimmunity-associated gene PTPN22 potentiates toll-like receptor-driven, type 1 interferon-dependent immunity.

N. Bottini, G. Cheng, K. Ley, 2013, Immunity.

Disruption of T cell signaling networks and development by Grb2 haploid insufficiency

T. Pawson, A. Cheng, J. Alberola-Ila, 2001, Nature Immunology.

Autoimmunity linked protein phosphatase PTPN22 as a target for cancer immunotherapy

R. Cubas, M. Moskalenko, Z. Khan, 2020, Journal for ImmunoTherapy of Cancer.

Ocrelizumab: A New Generation of anti‐CD20 mAbfor Treatment of Multiple Sclerosis

A. Chan, P. Brunetta, P. Chin, 2019, Successful Drug Discovery.

Anti-CD20 antibody promotes cancer escape via enrichment of tumor-evoked regulatory B cells expressing low levels of CD20 and CD137L.

M. Merino, R. Wersto, J. Lai, 2013, Cancer research.

Structural basis for Syk tyrosine kinase ubiquity in signal transduction pathways revealed by the crystal structure of its regulatory SH2 domains bound to a dually phosphorylated ITAM peptide.

G Waksman, G. Waksman, R. Grucza, 1998, Journal of molecular biology.

Functional characterization of a signal transducing motif present in the T cell antigen receptor zeta chain

A. Weiss, A. Chan, B. Irving, 1993, The Journal of experimental medicine.

BLNK Required for Coupling Syk to PLCγ2 and Rac1-JNK in B Cells

Andrew C. Chan, T. Kurosaki, A. Iwamatsu, 1999 .

BLNK: molecular scaffolding through ‘cis’‐mediated organization of signaling proteins

T. Kurosaki, A. Chan, C. Chiu, 2002, The EMBO journal.

Phosphorylation of SLP-76 by the ZAP-70 Protein-tyrosine Kinase Is Required for T-cell Receptor Function*

David H. Williams, Andrew C. Chan, A. Chan, 1996, The Journal of Biological Chemistry.

The Lck SH3 Domain Is Required for Activation of the Mitogen-activated Protein Kinase Pathway but Not the Initiation of T-cell Antigen Receptor Signaling*

Heather C. Kaufman, A. Chan, D. Straus, 1999, The Journal of Biological Chemistry.

Autoimmune-associated PTPN22 R620W Variation Reduces Phosphorylation of Lymphoid Phosphatase on an Inhibitory Tyrosine Residue*

Nunzio Bottini, Oreste Acuto, Edoardo Fiorillo, 2010, The Journal of Biological Chemistry.

Unique Signaling Properties of B Cell Antigen Receptor in Mature and Immature B Cells: Implications for Tolerance and Activation1

J. Cambier, A. Chan, R. Benschop, 2001, The Journal of Immunology.

PEST Domain-Enriched Tyrosine Phosphatase (PEP) Regulation of Effector/Memory T Cells

L. Diehl, A. Chan, F. Martin, 2004, Science.

Stratified medicine in inflammatory disorders: From theory to practice.

B. Yaspan, A. Chan, M. Keir, 2015, Clinical immunology.

Personalizing medicine for autoimmune and inflammatory diseases

T. Behrens, A. Chan, 2013, Nature Immunology.

Autoimmunity-associated protein tyrosine phosphatase PEP negatively regulates IFN-α receptor signaling

A. Chan, P. Caplazi, Wyne P. Lee, 2015, The Journal of experimental medicine.

SH2 Domain Function Is Essential for the Role of the Lck Tyrosine Kinase in T Cell Receptor Signal Transduction (*)

A. Weiss, A. Chan, D. Straus, 1996, The Journal of Biological Chemistry.

Regulation of thymocyte development: only the meek survive.

Andrew C Chan, A. Chan, P. Love, 2003, Current opinion in immunology.

A biosynthetic pathway for anandamide

Bill X. Huang, Hee-Yong Kim, Lei Wang, 2006, Proceedings of the National Academy of Sciences.

Dusp5 negatively regulates IL‐33‐mediated eosinophil survival and function

D. Yan, Min Xu, A. Chan, 2015, The EMBO journal.

The C4 and Slp genes of the complement region of the murine H-2 major histocompatibility complex.

D. Karp, J. Atkinson, P. Rosa, 1984, Philosophical transactions of the Royal Society of London. Series B, Biological sciences.

Origin of the fourth component of complement related Chido and Rodgers blood group antigens.

D. Karp, J. Atkinson, R. Levine, 1988, Complement.

Lee, K. H. et al. The role of receptor internalization in CD95 signaling. EMBO J. 25, 1009-1023

C. Hallas, M. Peter, A. Chan, 2006 .

Regulation of protein tyrosine kinase activation by the T-cell antigen receptor zeta chain.

A. Weiss, A. Chan, B. Irving, 1992, Cold Spring Harbor symposia on quantitative biology.

Thermodynamic study of the binding of the tandem-SH2 domain of the Syk kinase to a dually phosphorylated ITAM peptide: evidence for two conformers.

G. Waksman, R. Grucza, K. Fütterer, 1999, Biochemistry.

30 Years of Biotherapeutics Development-What Have We Learned?

A. Chan, N. Ghilardi, J. Arron, 2020, Annual review of immunology.

Recognition of Unique Carboxyl-Terminal Motifs by Distinct PDZ Domains

L. Cantley, Songyang Zhou, James M. Anderson, 1997, Science.

Importance of Cellular Microenvironment and Circulatory Dynamics in B Cell Immunotherapy1

L. Diehl, Yanmei Lu, Y. Meng, 2005, The Journal of Immunology.

Differential regulation of mast cell degranulation versus cytokine secretion by the actin regulatory proteins Coronin1a and Coronin1b

A. Chan, N. Föger, Kyeong-Hee Lee, 2011, The Journal of experimental medicine.

Dusp5 negatively regulates IL‐33‐mediated eosinophil survival and function

D. Yan, A. Chan, J. Yeh, 2015, The EMBO journal.

Syk Family of Protein Tyrosine Kinases

A. Chan, 2004 .

Regulation of a Late Phase of T Cell Polarity and Effector Functions by Crtam

S. Sidhu, A. Chan, J. Yeh, 2008, Cell.

A Specificity Map for the PDZ Domain Family

Gary D Bader, C. Sander, B. Reva, 2008, PLoS biology.

NLRP3 tyrosine phosphorylation is controlled by protein tyrosine phosphatase PTPN22

B. Becher, G. Rogler, S. Vavricka, 2023, The Journal of clinical investigation.

NLRP3 tyrosine phosphorylation is controlled by protein tyrosine phosphatase PTPN22.

B. Becher, G. Rogler, S. Vavricka, 2016, The Journal of clinical investigation.