D. Shawcross

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Salivary microbiota‐immune profiling in cirrhosis: Could this be the noninvasive strategy that will revolutionize prognostication in hepatology?

V. Patel, D. Shawcross, 2015, Hepatology.

Endotoxemia produces coma and brain swelling in bile duct ligated rats

C. Zwingmann, Roger Williams, R. Jalan, 2007, Hepatology.

In vitro efficacy of pro‐ and anticoagulant strategies in compensated and acutely ill patients with cirrhosis

V. Patel, D. Shawcross, S. Støy, 2018, Liver international : official journal of the International Association for the Study of the Liver.

Neutrophil CD64 expression is elevated in acetaminophen-induced acute liver failure.

D. Shawcross, J. Wendon, W. Bernal, 2012, American journal of respiratory and critical care medicine.

EASL Clinical Practice Guidelines on the management of hepatic encephalopathy.

D. Thabut, K. Weissenborn, D. Shawcross, 2022, Journal of hepatology.

PROFIT, a PROspective, randomised placebo controlled feasibility trial of Faecal mIcrobiota Transplantation in cirrhosis: study protocol for a single-blinded trial

A. Douiri, V. Patel, D. Shawcross, 2019, BMJ Open.

Statins: A Panacea to Reduce Mortality in Patients Undergoing Liver Transplantation for Hepatocellular Carcinoma?

D. Shawcross, A. Suddle, 2021, Liver transplantation : official publication of the American Association for the Study of Liver Diseases and the International Liver Transplantation Society.

Is it time to target gut dysbiosis and immune dysfunction in the therapy of hepatic encephalopathy?

D. Shawcross, 2015, Expert review of gastroenterology & hepatology.

The Level of Alcohol Consumption in the Prior Year Does Not Impact Clinical Outcomes in Patients With Alcohol‐Associated Hepatitis

R. Bataller, E. Verna, J. Eickhoff, 2021, Liver transplantation : official publication of the American Association for the Study of Liver Diseases and the International Liver Transplantation Society.

Comparison of scoring systems and outcome of patients admitted to a liver intensive care unit of a tertiary referral centre with severe variceal bleeding

M. Mcphail, G. Auzinger, J. Devlin, 2014, Alimentary pharmacology & therapeutics.

Low myo-inositol and high glutamine levels in the brain are associated with neuropsychological deterioration following induced hyperammonemia

I. Marshall, J. Wardlaw, R. Williams, 2004 .

Rifaximin reduces gut-derived inflammation and mucin degradation in cirrhosis and encephalopathy: RIFSYS randomised controlled trial.

E. Le Chatelier, N. Pons, S. Ehrlich, 2021, Journal of hepatology.

Soluble TIM3 and Its Ligands Galectin-9 and CEACAM1 Are in Disequilibrium During Alcohol-Related Liver Disease and Promote Impairment of Anti-bacterial Immunity

Roger Williams, N. Heaton, J. Trebicka, 2021, Frontiers in Physiology.

CEG_A_329424 441..449

H. Vilstrup, D. Shawcross, S. Støy, 2021 .

Activation and Functional Priming of Blood Neutrophils in Non-Alcoholic Fatty Liver Disease Increases in Non-Alcoholic Steatohepatitis

H. Vilstrup, D. Shawcross, S. Støy, 2021, Clinical and experimental gastroenterology.

CD14, CD16 and HLA‐DR reliably identifies human monocytes and their subsets in the context of pathologically reduced HLA‐DR expression by CD14hi/CD16neg monocytes: Expansion of CD14hi/CD16pos and contraction of CD14lo/CD16pos monocytes in acute liver failure

D. Vergani, M. Mcphail, D. Shawcross, 2012, Cytometry. Part A : the journal of the International Society for Analytical Cytology.

The microbiota in cirrhosis and its role in hepatic decompensation.

J. Trebicka, J. Bajaj, D. Shawcross, 2021, Journal of hepatology.

Intestinal Fungal Dysbiosis and Systemic Immune Response to Fungi in Patients With Alcoholic Hepatitis

R. Bataller, D. Fouts, M. Torralba, 2020, Hepatology.

targeting of gut bacterium attenuates alcoholic liver disease.

Elizabeth, D. Fouts, L. Eckmann, 2019 .

Meeting the challenge of antimicrobial resistance in cirrhosis: the invisible threat that lies within.

D. Shawcross, S. Goldenberg, L. Edwards, 2021, Gastroenterology.

Pathophysiology: Gut Liver Axis Changes

D. Shawcross, C. Woodhouse, 2018 .

Pathophysiological mechanisms of hepatic encephalopathy

D. Shawcross, T. Tranah, A. Paolino, 2015, Clinical liver disease.

Global and temporal state of the human gut microbiome in health and disease

Mathieu Almeida, N. Pons, E. Chatelier, 2021 .

Recent Findings in the Gut-Liver Axis and Associated Disease Therapy A of selected treatment-related

J. Bajaj, B. Mullish, D. Shawcross, 2022 .

Defective monocyte oxidative burst predicts infection in alcoholic hepatitis and is associated with reduced expression of NADPH oxidase

S. Atkinson, M. Thursz, G. Foster, 2016, Gut.

Could abnormal neutrophil‐platelet interactions and complex formation contribute to oxidative stress and organ failure in cirrhosis?

D. Shawcross, W. Bernal, J. Sturgeon, 2015, Hepatology.

Decompensation of chronic stable alcoholic liver disease by severe exfoliative dermatitis.

R. Jalan, D. Shawcross, R. Mookerjee, 2003, European journal of gastroenterology & hepatology.

Serum and Fecal Oxylipins in Patients with Alcohol-Related Liver Disease

D. Shawcross, S. Ho, P. Mathurin, 2019, Digestive Diseases and Sciences.

The PREDICT study uncovers three clinical courses in acutely decompensated cirrhosis with distinct pathophysiology (120/120).

M. Manns, C. Trautwein, T. Berg, 2020, Journal of Hepatology.

Dysregulation of serum bile acids and FGF19 in alcoholic hepatitis.

R. Bataller, D. Fouts, E. Verna, 2018, Journal of hepatology.

Important Unresolved Questions in the Management of Hepatic Encephalopathy: An ISHEN Consensus.

R. Dhiman, D. Thabut, B. Sharma, 2020, The American journal of gastroenterology.

The impact of rifaximin-α on the hospital resource use associated with the management of patients with hepatic encephalopathy: a retrospective observational study (IMPRESS)

R. Jalan, M. Hudson, P. Richardson, 2017, Frontline Gastroenterology.

The changing face of hepatic encephalopathy: A projection for the next 5 years

D. Shawcross, 2016, Clinical liver disease.

Mucosa-associated invariant T cells link intestinal immunity with antibacterial immune defects in alcoholic liver disease

P. Klenerman, Y. Oo, J. Bajaj, 2017, Gut.

Effect of rifaximin on infections, acute‐on‐chronic liver failure and mortality in alcoholic hepatitis: A pilot study (RIFA‐AH)

R. Schwabe, R. Bataller, M. Poca, 2022, Liver international : official journal of the International Association for the Study of the Liver.

Dispelling myths in the treatment of hepatic encephalopathy

R. Jalan, D. Shawcross, 2005, The Lancet.

540 A COMPENSATORY ANTI-INFLAMMATORY RESPONSE SYNDROME (CARS) TRIGGERED BY NEUTROPHIL-INDUCED OXIDATIVE STRESS IS ASSOCIATED WITH CHRONIC LOW GRADE HEPATIC ENCEPHALOPATHY IN PATIENTS WITH ADVANCED CIRRHOSIS

D. Shawcross, J. Wendon, Yun Ma, 2010 .

Ammonia-Induced Brain Edema Requires Macrophage and T Cell Expression of Toll-Like Receptor 9

L. Wen, Changyun Hu, R. Verghis, 2019, Cellular and molecular gastroenterology and hepatology.

Systemic inflammation and ammonia in hepatic encephalopathy

D. Shawcross, G. M. Vijay, J. Ryan, 2012, Metabolic Brain Disease.

PMO-125 Neutrophil intracellular toll-like receptor (TLR) 9 expression serves as a biomarker that determines presence and severity of encephalopathy in acute liver failure and cirrhosis

S. Ramage, D. Shawcross, J. Wendon, 2012, Gut.

The severity of circulating neutrophil dysfunction in patients with cirrhosis is associated with 90‐day and 1‐year mortality

G. Auzinger, D. Shawcross, W. Bernal, 2014, Alimentary pharmacology & therapeutics.

Role of ammonia and inflammation in minimal hepatic encephalopathy

R. Jalan, D. Shawcross, S. O. Olde Damink, 2007, Metabolic Brain Disease.

Editorial: rifaximin—a kick in the gut for spontaneous bacterial peritonitis?

D. Shawcross, C. Woodhouse, 2018, Alimentary pharmacology & therapeutics.

Systemic inflammatory response exacerbates the neuropsychological effects of induced hyperammonemia in cirrhosis.

Roger Williams, R. Jalan, D. Shawcross, 2004, Journal of hepatology.

Diarrhoea and preadmission antibiotic exposure in COVID-19: a retrospective cohort study of 1153 hospitalised patients

B. Hayee, D. Shawcross, J. Galloway, 2021, BMJ open gastroenterology.

Ammonia and the neutrophil in the pathogenesis of hepatic encephalopathy in cirrhosis

R. Hughes, D. Shawcross, N. Taylor, 2010, Hepatology.

Hepatic encephalopathy and depression in chronic liver disease: is the common link systemic inflammation?

D. Shawcross, V. Kronsten, 2021, Analytical biochemistry.

Bacteriophage targeting of gut bacterium attenuates alcoholic liver disease

R. Bataller, D. Fouts, L. Eckmann, 2019, Nature.

Alcohol dehydrogenase–specific T‐cell responses are associated with alcohol consumption in patients with alcohol‐related cirrhosis

M. Hussain, D. Vergani, N. Heaton, 2013, Hepatology.

Pathophysiology of cerebral oedema in acute liver failure.

R. Hughes, D. Shawcross, V. Kronsten, 2013, World journal of gastroenterology.

Ammonia and Hepatic Encephalopathy: The More Things Change, the More They Remain the Same

R. Butterworth, R. Jalan, D. Shawcross, 2005, Metabolic Brain Disease.

High-volume plasma exchange in patients with acute liver failure: An open randomised controlled trial.

G. Auzinger, H. Isoniemi, V. Patel, 2016, Journal of hepatology.

Targeting the gut-liver-immune axis to treat cirrhosis

D. Shawcross, B. Schnabl, T. Tranah, 2020, Gut.

Clinical science workshop: targeting the gut-liver-brain axis

J. Bajaj, V. Patel, D. Shawcross, 2015, Metabolic Brain Disease.

Inflammation and hepatic encephalopathy.

D. Shawcross, T. Tranah, I. Coltart, 2013, Archives of biochemistry and biophysics.

Implications and Management of Cirrhosis‐Associated Immune Dysfunction Before and After Liver Transplantation

D. Shawcross, V. Kronsten, T. Tranah, 2021, Liver transplantation : official publication of the American Association for the Study of Liver Diseases and the International Liver Transplantation Society.

Pathogenesis of hepatic encephalopathy: role of ammonia and systemic inflammation.

D. R. Aldridge, D. Shawcross, E. Tranah, 2015, Journal of clinical and experimental hepatology.

Systemic inflammation and ammonia in hepatic encephalopathy

D. Shawcross, G. M. Vijay, J. Ryan, 2013, Metabolic Brain Disease.

Regulation, risk and safety of Faecal Microbiota Transplant

D. Shawcross, B. Merrick, Benjamin Forbes, 2020, Infection Prevention in Practice.

The Reactobiome Unravels a New Paradigm in Human Gut Microbiome Metabolism

Mathieu Almeida, E. Chatelier, S. Ehrlich, 2021, bioRxiv.

Balanced haemostasis with both hypo‐ and hyper‐coagulable features in critically ill patients with acute‐on‐chronic‐liver failure

V. Patel, D. Shawcross, J. Wendon, 2018, Journal of critical care.

Intestinal Virome in Patients With Alcoholic Hepatitis

D. Brenner, R. Bataller, D. Fouts, 2020, Hepatology.

Brain cytokine flux in acute liver failure and its relationship with intracranial hypertension

R. Jalan, D. Shawcross, S. O. Olde Damink, 2007, Metabolic Brain Disease.

Character and Temporal Evolution of Apoptosis in Acetaminophen-Induced Acute Liver Failure*

M. Mcphail, N. Heaton, M. Thursz, 2013, Critical Care Medicine.

Recent insights into the pathogenesis of hepatic encephalopathy and treatments

D. Shawcross, J. Sturgeon, Jonathan P. Sturgeon, 2014, Expert review of gastroenterology & hepatology.

Neutrophil gelatinase—Associated lipocalin predicts acute kidney injury in patients undergoing liver transplantation

M. Mcphail, M. Heneghan, D. Shawcross, 2010, Liver transplantation : official publication of the American Association for the Study of Liver Diseases and the International Liver Transplantation Society.

Should a biopsy precede liver resection or transplantation for presumed hepatocellular carcinoma when the alfa fetoprotein is normal?

Roger Williams, W. Lees, R. Jalan, 2004, Transplantation.

Neutrophil Toll-Like Receptor 9 Expression and the Systemic Inflammatory Response in Acetaminophen-Induced Acute Liver Failure

M. Mcphail, G. Auzinger, S. Ramage, 2016, Critical care medicine.

Infection and systemic inflammation, not ammonia, are associated with Grade 3/4 hepatic encephalopathy, but not mortality in cirrhosis.

G. Auzinger, D. Shawcross, J. Wendon, 2011, Journal of Hepatology.

Plasma ammonia levels predict hospitalisation with liver-related complications and mortality in clinically stable outpatients with cirrhosis.

R. Jalan, C. Montoliu, J. Ampuero, 2022, Journal of hepatology.

The 6-month abstinence rule in liver transplantation

J. O'grady, D. Shawcross, 2010, The Lancet.

The molecular pathogenesis of hepatic encephalopathy.

R. Jalan, D. Shawcross, N. Davies, 2003, The international journal of biochemistry & cell biology.

Low myo-inositol and high glutamine levels in brain are associated with neuropsychological deterioration after induced hyperammonemia.

I. Marshall, P. Hayes, J. Wardlaw, 2004, American journal of physiology. Gastrointestinal and liver physiology.

The pathophysiologic basis of hepatic encephalopathy: central role for ammonia and inflammation

R. Jalan, D. Shawcross, 2005, Cellular and Molecular Life Sciences CMLS.

Cerebral oedema is rare in acute‐on‐chronic liver failure patients presenting with high‐grade hepatic encephalopathy

G. Auzinger, J. O'grady, D. Shawcross, 2014, Liver international : official journal of the International Association for the Study of the Liver.

Dysfunctional neutrophil effector organelle mobilization and microbicidal protein release in alcohol-related cirrhosis.

D. Shawcross, R. Abeles, G. M. Vijay, 2017, American journal of physiology. Gastrointestinal and liver physiology.

Severe alcohol-related liver disease admissions post-COVID-19 lockdown: canary in the coal mine?

Roger Williams, K. Agarwal, D. Shawcross, 2020, Frontline Gastroenterology.

Multivariate metabotyping of plasma accurately predicts survival in patients with decompensated cirrhosis *

Holmes, K. Veselkov, E. Want, 2017 .

Multivariate metabotyping of plasma predicts survival in patients with decompensated cirrhosis

K. Veselkov, E. Want, M. Mcphail, 2016, Journal of hepatology.

Anti-tumor necrosis factor-alpha monoclonal antibody therapy in severe alcoholic hepatitis.

H. Tilg, C. Datz, A. Kaser, 2003, Journal of hepatology.

Gut-derived systemic inflammation as a driver of depression in chronic liver disease.

C. Pariante, D. Shawcross, V. Kronsten, 2021, Journal of hepatology.

Prognosis of cirrhotic patients admitted to intensive care unit: a meta-analysis

R. Cavallazzi, M. Mcphail, A. Burroughs, 2017, Annals of Intensive Care.

The neurological manifestations of acute liver failure

D. Shawcross, J. Wendon, 2012, Neurochemistry International.

Changing face of hepatic encephalopathy: role of inflammation and oxidative stress.

R. Hughes, D. Shawcross, Amit S Seyan, 2010, World journal of gastroenterology.

How to diagnose and manage hepatic encephalopathy: a consensus statement on roles and responsibilities beyond the liver specialist

Rajiv Jalan, Gerald Kircheis, Wim Laleman, 2015, European journal of gastroenterology & hepatology.

Diagnosis and management of hepatic encephalopathy.

D. Shawcross, 2018, British journal of nursing.

Treatment of hepatic encephalopathy: It's not lactulose

R. Jalan, D. Shawcross, 2004, BMJ : British Medical Journal.

The impact on hospital resource utilisation of treatment of hepatic encephalopathy with rifaximin‐α

M. Hudson, P. Richardson, J. Dillon, 2016, Liver international : official journal of the International Association for the Study of the Liver.

Subacute liver failure secondary to black cohosh leading to liver transplantation

A. Quaglia, D. Shawcross, T. Y. Lim, 2013, BMJ Case Reports.

Blockade of PD1 and TIM3 restores innate and adaptive immunity in patients with acute alcoholic hepatitis.

Roger Williams, M. Thursz, J. O'grady, 2015, Gastroenterology.

Faecal microbiota transplant to ERadicate gastrointestinal carriage of Antibiotic Resistant Organisms (FERARO): a prospective, randomised placebo-controlled feasibility trial

J. Bell, M. Shankar-Hari, C. Bunce, 2020, BMJ Open.

Is treating the gut microbiome the key to achieving better outcomes in cirrhosis?

D. Shawcross, Grace Hatton, 2018, Expert review of gastroenterology & hepatology.

Ammonia impairs neutrophil phagocytic function in liver disease

A. Pitsillides, R. Jalan, V. Stadlbauer, 2008, Hepatology.

Trajectory of Serum Bilirubin Predicts Spontaneous Recovery in a Real-World Cohort of Patients with Alcoholic Hepatitis.

R. Bataller, E. Verna, D. Shawcross, 2021, Clinical gastroenterology and hepatology : the official clinical practice journal of the American Gastroenterological Association.

Clinical and cytokine response to anti-TNF antibody therapy in severe alcoholic hepatitis.

H. Tilg, A. Kaser, R. Jalan, 2001 .

Plasma angiopoietin 2 as a novel prognostic biomarker in alcohol-related cirrhosis and hepatitis

R. Bataller, D. Shawcross, V. Kronsten, 2022, Liver Research.

Acute liver failure and the brain: a look through the crystal ball

D. Shawcross, J. Wendon, R. Mitry, 2013, Metabolic Brain Disease.

Worsening of cerebral hyperemia by the administration of terlipressin in acute liver failure with severe encephalopathy

P. Hayes, Roger Williams, R. Jalan, 2004, Hepatology.

245 NEUTROPHIL INTRACELLULAR TOLL-LIKE RECEPTOR (TLR) 9 EXPRESSION SERVES AS A BIOMARKER THAT DETERMINES PRESENCE AND SEVERITY OF ENCEPHALOPATHY IN ACUTE LIVER FAILURE AND CIRRHOSIS

M. Mcphail, S. Ramage, D. Shawcross, 2012 .

Acute-on-Chrenic Liver Failure in Cirrhosis: Defining and Managing Organ Dysfunction

D. Shawcross, J. Wendon, 2009 .

The impact of organ dysfunction in cirrhosis: survival at a cost?

M. Mcphail, G. Auzinger, D. Shawcross, 2012, Journal of hepatology.

Lessons Learned from Faecal Microbiota Transplantation in Cirrhosis

D. Shawcross, T. Tranah, Shaolu Ran, 2020, Current Hepatology Reports.

Clinical, histological and molecular profiling of different stages of alcohol-related liver disease

M. Ziol, C. Sempoux, J. Woosley, 2022, Gut.

Increased Survival for Patients With Cirrhosis and Organ Failure in Liver Intensive Care and Validation of the Chronic Liver Failure-Sequential Organ Failure Scoring System.

M. Mcphail, G. Auzinger, V. Patel, 2015, Clinical gastroenterology and hepatology : the official clinical practice journal of the American Gastroenterological Association.

PREDICT identifies precipitating events associated with the clinical course of acutely decompensated cirrhosis.

M. Manns, C. Trautwein, T. Berg, 2020, Journal of hepatology.

Circulating neutrophil dysfunction in acute liver failure

G. Auzinger, D. Shawcross, J. Wendon, 2013, Hepatology.

Meld score and serum sodium in the prediction of survival of patients with cirrhosis awaiting liver transplantation

D. Shawcross, M. Austin, I. Coltart, 2007 .

Modulation of the Gut Microbiota to Control Antimicrobial Resistance (AMR)—A Narrative Review with a Focus on Faecal Microbiota Transplantation (FMT)

D. Shawcross, D. Moyes, B. Merrick, 2023, Infectious disease reports.

Real-world evidence of long-term survival and healthcare resource use in patients with hepatic encephalopathy receiving rifaximin-α treatment: a retrospective observational extension study with long-term follow-up (IMPRESS II)

P. Richardson, D. Shawcross, R. Aspinall, 2022, Frontline Gastroenterology.

Rifaximin reduces the incidence of spontaneous bacterial peritonitis, variceal bleeding and all‐cause admissions in patients on the liver transplant waiting list

N. Heaton, M. Heneghan, V. Patel, 2019, Alimentary pharmacology & therapeutics.