C. Cuevas

发表

Detection of a pederin‐like compound using a dilution‐to‐extinction‐based platform for the isolation of marine bacteria in drug discovery strategies

Jesús García, X. Benítez, Elena G Gonzalez, 2020, Microbial biotechnology.

Isolation and first total synthesis of PM050489 and PM060184, two new marine anticancer compounds.

F. Reyes, C. Cuevas, S. Munt, 2013, Journal of the American Chemical Society.

Enigmazole C: A Cytotoxic Macrocyclic Lactone and Its Ring-Opened Derivatives from a New Species of Homophymia Sponge

C. Cuevas, Jaime Rodríguez, C. Jiménez, 2022, Journal of natural products.

Identification of trans-AT polyketide clusters in two marine bacteria reveals cryptic similarities between distinct symbiosis factors

J. García, B. Galán, Elena G Gonzalez, 2020, bioRxiv.

Total solid-phase synthesis of the azathiocoraline class of symmetric bicyclic peptides.

Fernando Albericio, Mercedes Alvarez, Carmen Cuevas, 2006, Chemistry.

Enzyme-labile protecting groups for the synthesis of natural products: solid-phase synthesis of thiocoraline.

Miriam Góngora-Benítez, Judit Tulla-Puche, F. Albericio, 2013, Angewandte Chemie.

A new approach to 3-hydroxyquinoline-2-carboxylic acid

F. Albericio, C. Cuevas, M. Álvarez, 2005 .

Batzelladine alkaloids from the caribbean sponge Monanchora unguifera and the significant activities against HIV-1 and AIDS opportunistic infectious pathogens

R. Schinazi, M. Hamann, C. Cuevas, 2007 .

Lanesoic Acid: A Cytotoxic Zwitterion from Theonella sp.

C. Cuevas, Jaime Rodríguez, C. Jiménez, 2016, Organic letters.

Combining JBCA and Marfey's methodology to determine the absolute configuration of threonines: the case of gunungamide A, a new cyclic depsipeptide containing chloropyrrole from the sponge Discodermia sp.

C. Cuevas, Jaime Rodríguez, C. Jiménez, 2019, Organic Chemistry Frontiers.

Isolation and structures of pipecolidepsins A and B, cytotoxic cyclic depsipeptides from the Madagascan sponge Homophymia lamellosa.

F. Reyes, C. Cuevas, María Jesús Martín, 2014, Journal of natural products.

Stellatolides, a new cyclodepsipeptide family from the sponge Ecionemia acervus: isolation, solid-phase total synthesis, and full structural assignment of stellatolide A.

Judit Tulla-Puche, F. Albericio, F. Reyes, 2014, Journal of the American Chemical Society.

Pembamide, a N-methylated linear peptide from a sponge Cribrochalina sp.

C. Cuevas, Jaime Rodríguez, C. Jiménez, 2016 .

Bioconjugation through Mesitylene Thiol Alkylation.

F. Sánchez‐Madrid, J. Zapata, F. Albericio, 2018, Bioconjugate chemistry.

Synthesis and Structure–Activity Relationship of Cytotoxic Marine Cyclodepsipeptide IB‐01212 Analogues

F. Albericio, C. Cuevas, A. Francesch, 2007, ChemMedChem.

New cytotoxic diterpenylnaphthohydroquinone derivatives obtained from a natural diterpenoid.

C. Cuevas, A. San Feliciano, P. Chamorro, 2007, Bioorganic & medicinal chemistry.

Synthesis, characterisation, and antineoplastic cytotoxicity of hybrid naphthohydroquinone–nucleic base mimic derivatives

C. Cuevas, A. Oliva, A. San Feliciano, 2009, Medicinal Chemistry Research.

Cytotoxic‐Antineoplastic Derivatives of Prenyl‐1,2‐naphthohydroquinone

C. Cuevas, A. Oliva, A. San Feliciano, 2008, Archiv der Pharmazie.

Synthesis of Ecteinascidin 743 Analogues from Cyanosafracin B: Isolation of a Kinetically Stable Quinoneimine Tautomer of a 5‐Hydroxyindole

C. Cuevas, A. Echavarren, A. Francesch, 2006 .

Solid-Phase Synthesis of Aza-Kahalalide F Analogues: (2R,3R)-2-Amino-3-azidobutanoic Acid as Precursor of the Aza-Threonine

Judit Tulla-Puche, F. Albericio, C. Cuevas, 2010 .

Diazonamides C–E, new cytotoxic metabolites from the ascidian Diazona sp.

F. Reyes, C. Cuevas, R. Fernández, 2008 .

Synthesis and structure-activity relationship study of potent cytotoxic analogues of the marine alkaloid Lamellarin D.

Fernando Albericio, Andrés Francesch, Mercedes Alvarez, 2006, Journal of medicinal chemistry.

Contribution to the development of new substitution patterns of optically active .beta.-lactams: synthesis of homochiral 4-(1-aminoalkyl)azetidin-2-ones from N-(tert-butyloxycarbonyl) .alpha.-amino aldehyde-derived imines via asymmetric Staudinger reaction

C. Cuevas, F. Cossío, C. Palomo, 1992 .

Synthesis and cytotoxic evaluation of new derivatives of the marine alkaloid variolin B.

P. Molina, C. Cuevas, A. Francesch, 2006, Journal of medicinal chemistry.

Synthesis of Polyheterocyclic Nitrogen-Containing Marine Natural Products

Pablo Cironi, F. Albericio, C. Cuevas, 2004 .

Total syntheses of variolin B and deoxyvariolin B.

F. Albericio, C. Cuevas, J. Joule, 2003, The Journal of organic chemistry.

Synthesis of variolin B

F. Albericio, C. Cuevas, J. Joule, 2003 .

Topoisomerase I-mediated DNA cleavage as a guide to the development of antitumor agents derived from the marine alkaloid lamellarin D: triester derivatives incorporating amino acid residues.

C. Bailly, C. Tardy, C. Cuevas, 2004, Bioorganic & medicinal chemistry.

Stereocontrolled synthesis of 3,5-dialkyl-4-amino pyrrolidin-2-ones from β-lactams as chiral templates.

J. Odriozola, C. Cuevas, J. Ontoria, 1992 .

New cytotoxic furoquinones obtained from terpenyl-1,4-naphthoquinones and 1,4-anthracenediones.

A. Oliveira, S. Gualberto, C. Cuevas, 2006, Bioorganic & medicinal chemistry.

Synthesis and cytotoxicity of new heterocyclic terpenylnaphthoquinones.

C. Cuevas, M. Gordaliza, J. M. Miguel del Corral, 2006, Bioorganic & medicinal chemistry.

Dearomatizing anionic cyclization of N-methyl-N-benzyldi(1-naphthyl)phosphinamide: a route for access to a new class of functionalized tricyclic azaphospholes with antitumor properties

M. Serrano-Ruiz, C. Cuevas, M. Iglesias, 2012 .

Total synthesis and biological evaluation of tamandarin B analogues.

C. Cuevas, M. Joullié, J. Adrio, 2007, The Journal of organic chemistry.

Generation of Threonine- and Azathreonine N-Carboxy Anhydrides from alpha-Hydroxy beta-Lactams Promoted by 2,2,6,6-Tetramethylpiperidinyl-1-oxyl (TEMPO) in Combination with Sodium Hypochlorite.

C. Cuevas, A. Linden, J. Aizpurua, 1996, The Journal of organic chemistry.

Lamellarin D bioconjugates I: Synthesis and cellular internalization of PEG-derivatives.

Fernando Albericio, Andrés Francesch, Mercedes Alvarez, 2009, Bioconjugate chemistry.

Asymmetric synthesis of monocyclic β-lactams: application of imines derived from chiral N-protected α-amino aldehydes in the staudinger reaction

C. Cuevas, F. Cossío, C. Palomo, 1991 .

New cytotoxic-antineoplastic prenyl-1,2-naphthohydroquinone derivatives.

C. Cuevas, A. Oliva, A. San Feliciano, 2005, Bioorganic & medicinal chemistry.

From Ugi Multicomponent Reaction to Linkers for Bioconjugation

F. Sánchez‐Madrid, J. Zapata, F. Albericio, 2020, ACS omega.

Development of Yondelis (trabectedin, ET-743). A semisynthetic process solves the supply problem.

Andrés Francesch, Carmen Cuevas, C. Cuevas, 2009, Natural product reports.

Synthesis and Cytotoxic Evaluation of 6‐(3‐Pyrazolylpropyl) Derivatives of 1,4‐Naphthohydroquinone‐1,4‐diacetate

C. Cuevas, A. Oliva, A. San Feliciano, 2009, Archiv der Pharmazie.

Unique Polyhalogenated Peptides from the Marine Sponge Ircinia sp.

C. Cuevas, R. Fernández, Santiago Bueno, 2020, Marine drugs.

Structure-activity relationship of kahalalide F synthetic analogues.

E. Giralt, F. Albericio, C. Cuevas, 2008, Journal of medicinal chemistry.

Total synthesis of natural myriaporones.

F. Reyes, C. Cuevas, C. del Pozo, 2004, Angewandte Chemie.

Synthetic Aspects of Homochiral β-Lactams Derived from N-Protected α-Aminoimines Via Asymmetric [2+2] Cycloaddition Reaction

J. Odriozola, C. Cuevas, S. Munt, 2010 .

New Synthesis of .alpha.-Amino Acid N-Carboxy Anhydrides through Baeyer-Villiger Oxidation of .alpha.-Keto .beta.-Lactams

F. Carreaux, C. Cuevas, J. Ontoria, 1994 .

A mild method for the alcoholysis of β-lactams

C. Cuevas, J. Aizpurua, C. Palomo, 1995 .

A route to dipeptides containing β-amino-α-hydroxy acid fragments by coupling of N-boc-β-lactams with α-amino esters. Application to the synthesis of (–)-bestatin

C. Cuevas, J. Aizpurua, C. Palomo, 1994 .

A CONVENIENT METHOD FOR BETA -LACTAM FORMATION FROM BETA -AMINO ACIDS USING PHENYL PHOSPHORODICHLORIDATE REAGENT

C. Cuevas, J. Aizpurua, C. Palomo, 1991 .

A concise synthesis of piperazine-2-carboxylic acids via β-lactam-derived α-amino acid N-carboxy anhydrides

C. Cuevas, C. Boschetti, A. Linden, 1997 .

New Synthesis of α-Amino Acid N-Carboxy Anhydrides Through Baeyer-Villiger Oxidation of α-Keto β-Lactams.

F. Carreaux, C. Cuevas, J. Ontoria, 1994 .

Optically active 1,3,4,4-tetrasubstituted β-lactams: synthesis and evaluation as tumor cell growth inhibitors.

M. García-López, R. González-Muñiz, C. Cuevas, 2011, European journal of medicinal chemistry.

Diastereoselective [2 + 2] cycloaddition of dichloroketene with α-oxyaldehydes and α-amino aldehydes

J. I. Miranda, J. Odriozola, C. Cuevas, 1995 .

Phormidolides B and C, cytotoxic agents from the sea: enantioselective synthesis of the macrocyclic core.

F. Albericio, C. Cuevas, M. Álvarez, 2015, Chemistry.

Modification at the C9 position of the marine natural product isoaaptamine and the impact on HIV-1, mycobacterial, and tumor cell activity.

R. Schinazi, M. Hamann, C. Cuevas, 2006, Bioorganic & medicinal chemistry.

Synthesis and biological evaluation of new podophyllic aldehyde derivatives with cytotoxic and apoptosis-inducing activities.

F. Mollinedo, C. Cuevas, A. San Feliciano, 2010, Journal of medicinal chemistry.

Stereocontrolled Synthesis of 3,5‐Dialkyl‐4‐amino Pyrrolidin‐2‐ones from β‐Lactams as Chiral Templates.

J. Odriozola, C. Cuevas, J. Ontoria, 1993 .

Preparation of penta-azole containing cyclopeptides: challenges in macrocyclization

F. Albericio, C. Cuevas, M. Álvarez, 2007 .

Njaoamines A–F, new cytotoxic polycyclic alkaloids from the haplosclerid sponge Reniera sp.

F. Reyes, C. Cuevas, R. Fernández, 2007 .

Halogenated helianane derivatives from the sponge Spirastrella hartmani.

F. Reyes, C. Cuevas, R. Fernández, 2005, Journal of Natural Products.

Total solid-phase synthesis of marine cyclodepsipeptide IB-01212.

E. Giralt, F. Albericio, C. Cuevas, 2006, The Journal of organic chemistry.

Identification of trans-AT polyketide clusters in two marine bacteria reveals cryptic similarities between distinct symbiosis factors.

J. García, B. Galán, Elena G Gonzalez, 2021, Environmental microbiology.

The first total synthesis of the cyclodepsipeptide pipecolidepsin A

Judit Tulla-Puche, F. Albericio, C. Cuevas, 2013, Nature Communications.

Aplicyanins A–F, new cytotoxic bromoindole derivatives from the marine tunicate Aplidium cyaneum

F. Reyes, S. Taboada, C. Cuevas, 2008 .

PM100117 and PM100118, new antitumor macrolides produced by a marine Streptomyces caniferus GUA-06-05-006A

F. Reyes, Paz E. Zúñiga, C. Cuevas, 2015, The Journal of Antibiotics.

Synthesis of IB-01211, a cyclic peptide containing 2,4-concatenated thia- and oxazoles, via Hantzsch macrocyclization.

F. Albericio, G. Vilar, C. Cuevas, 2007, Organic letters.

Synthesis, characterisation and cytotoxicity of chloro derivatives of prenylnaphthohydroquinone.

C. Cuevas, A. Oliva, A. San Feliciano, 2005, Bioorganic & medicinal chemistry.

Synthesis and antitumor activity of mechercharmycin A analogues.

F. Albericio, C. Cuevas, M. Álvarez, 2008, Journal of medicinal chemistry.

Tanjungides A and B: New Antitumoral Bromoindole Derived Compounds from Diazona cf formosa. Isolation and Total Synthesis

F. Reyes, C. Cuevas, S. Munt, 2014, Marine drugs.

Complete mitochondrial genome of Polymastia littoralis (Demospongiae, Polymastiidae)

J. García, B. Galán, C. del Cerro, 2016, Mitochondrial DNA. Part A, DNA mapping, sequencing, and analysis.

Daedophamide, a Cytotoxic Cyclodepsipeptide from a Daedalopelta sp. Sponge Collected in Indonesia.

C. Cuevas, Jaime Rodríguez, C. Jiménez, 2017, Journal of natural products.

Bacterial Production of a Pederin Analogue by a Free-Living Marine Alphaproteobacterium.

Paz E. Zúñiga, F. de la Calle, C. Cuevas, 2017, Journal of natural products.

On the Mechanism of Action of Dragmacidins I and J, Two New Representatives of a New Class of Protein Phosphatase 1 and 2A Inhibitors

C. Cuevas, A. Daranas, Marta Pérez, 2018, ACS omega.

Synthesis and cytotoxicity of new aminoterpenylquinones.

S. Gualberto, C. Cuevas, M. Gordaliza, 2005, Bioorganic & medicinal chemistry.

Gaining diversity in solid-phase synthesis by modulation of cleavage conditions from hydroxymethyl-based supports. Application to lamellarin synthesis

Pablo Cironi, F. Albericio, C. Cuevas, 2004 .

Can Stereoclusters Separated by Two Methylene Groups Be Related by DFT Studies? The Case of the Cytotoxic Meroditerpenes Halioxepines.

C. Cuevas, Jaime Rodríguez, C. Jiménez, 2018, Journal of natural products.

Protoxenicins A and B, Cytotoxic Long-Chain Acylated Xenicanes from the Soft Coral Protodendron repens.

C. Cuevas, Jaime Rodríguez, C. Jiménez, 2017, Journal of natural products.

Njaoamine I, a cytotoxic polycyclic alkaloid from the Haplosclerida sponge Haliclona (Reniera) sp.

C. Cuevas, Jaime Rodríguez, C. Jiménez, 2018, Tetrahedron Letters.

Dearomatizing anionic cyclization of phosphonamides. A route to phosphonic acid derivatives with antitumor properties.

M. Serrano-Ruiz, C. Cuevas, M. Iglesias, 2008, Organic letters.

Double dearomatization of bis(diphenylphosphinamides) through anionic cyclization. A facile route of accessing multifunctional systems with antitumor properties.

M. Serrano-Ruiz, S. García‐Granda, C. Cuevas, 2007, The Journal of organic chemistry.

Synthesis and biological evaluation of tamandarin B analogues.

C. Cuevas, M. Joullié, J. Adrio, 2006, Organic letters.

Synthesis and Antitumor Activity of Mechercharmycin A Analogs

F. Albericio, C. Cuevas, M. Álvarez, 2013 .

Highly functionalized β-lactams and 2-ketopiperazines as TRPM8 antagonists with antiallodynic activity

G. Fernández-Ballester, M. Bonache, A. Fernández-Carvajal, 2020, Scientific Reports.

Stolonoxides E and F, cytotoxic metabolites from the marine ascidian Stolonica socialis.

F. Reyes, C. Cuevas, R. Fernández, 2010, Journal of natural products.

Bistratamides M and N, Oxazole-Thiazole Containing Cyclic Hexapeptides Isolated from Lissoclinum bistratum Interaction of Zinc (II) with Bistratamide K

C. Cuevas, Jaime Rodríguez, C. Jiménez, 2017, Marine drugs.

Streptenols F-I Isolated from the Marine-Derived Streptomyces misionensis BAT-10-03-023.

C. Cuevas, C. Schleissner, Guillermo Tarazona, 2017, Journal of natural products.

Convergent approaches for the synthesis of the antitumoral peptide, Kahalalide F. Study of orthogonal protecting groups.

E. Giralt, F. Albericio, C. Cuevas, 2006, Journal of Organic Chemistry.

Isolation and first total synthesis of PM050489 and PM060184, two new marine anticancer compounds.

F. Reyes, C. Cuevas, S. Munt, 2013, Journal of the American Chemical Society.

Optically active 1,3,4,4-tetrasubstituted β-lactams: synthesis and evaluation as tumor cell growth inhibitors.

M. García-López, R. González-Muñiz, C. Cuevas, 2011, European journal of medicinal chemistry.