G. Fritz

发表

Platinum-induced kidney damage: Unraveling the DNA damage response (DDR) of renal tubular epithelial and glomerular endothelial cells following platinum injury.

J. Thomale, Katharina Krüger, N. Stojanović, 2015, Biochimica et biophysica acta.

Cisplatin sensitivity is related to late DNA damage processing and checkpoint control rather than to the early DNA damage response.

B. Kaina, W. Roos, M. Osmak, 2009, Mutation research.

Ultraviolet light-induced DNA damage triggers apoptosis in nucleotide excision repair-deficient cells via Bcl-2 decline and caspase-3/-8 activation

B. Kaina, T. Dunkern, G. Fritz, 2001, Oncogene.

Rho GTPases are over‐expressed in human tumors

B. Kaina, I. Just, G. Fritz, 1999, International journal of cancer.

Azathioprine Suppresses Ezrin-Radixin-Moesin-Dependent T Cell-APC Conjugation through Inhibition of Vav Guanosine Exchange Activity on Rac Proteins

M. Neurath, P. Galle, S. Wirtz, 2006, The Journal of Immunology.

Rho GTPases: promising cellular targets for novel anticancer drugs.

B. Kaina, G. Fritz, 2006, Current cancer drug targets.

Human APE/Ref-1 protein.

G. Fritz, 2000, The international journal of biochemistry & cell biology.

Transcriptional activation of the small GTPase gene rhoB by genotoxic stress is regulated via a CCAAT element.

B. Kaina, G. Fritz, Bernd Kaina, 2001, Nucleic acids research.

P38 MAP Kinase Signaling Is Required for the Conversion of CD4+CD25− T Cells into iTreg

A. Waisman, M. Blessing, J. Herkel, 2008, PloS one.

Activation of c-Jun N-Terminal Kinase 1 by UV Irradiation Is Inhibited by Wortmannin without Affecting c-jun Expression

B. Kaina, G. Fritz, 1999, Molecular and Cellular Biology.

Rho GTPases Are Involved in the Regulation of NF-κB by Genotoxic Stress

B. Kaina, G. Fritz, R. Gnad, 2001 .

Lovastatin attenuates ionizing radiation-induced normal tissue damage in vivo.

K. Lackner, G. Fritz, M. Torzewski, 2009, Radiotherapy and oncology : journal of the European Society for Therapeutic Radiology and Oncology.

K. Rothkamm, R. Knecht, Katharina Krüger, 2016, Oncotarget.

BER, MGMT, and MMR in defense against alkylation-induced genotoxicity and apoptosis.

M. Christmann, M. Tomicic, B. Kaina, 2001, Progress in nucleic acid research and molecular biology.

Clostridium difficile toxin B acts on the GTP-binding protein Rho.

K. Aktories, P. Boquet, C. von Eichel-Streiber, 1994, The Journal of biological chemistry.

Vav Guanosine Exchange Activity on Rac Cell-APC Conjugation through Inhibition of Ezrin-Radixin-Moesin-Dependent T Azathioprine Suppresses

M. Neurath, P. Galle, S. Wirtz, 2005 .

Ultraviolet light-induced apoptotic death is impaired by the HMG-CoA reductase inhibitor lovastatin.

B. Kaina, G. Fritz, R. V. Bardeleben, 2003, Biochemical and biophysical research communications.

Inhibition of protein isoprenylation impairs rho-regulated early cellular response to genotoxic stress.

B. Kaina, K. Aktories, G. Fritz, 2000, Molecular pharmacology.

Rac1 signaling protects monocytic AML cells expressing the MLL-AF9 oncogene from caspase-mediated apoptotic death

B. Kaina, C. Henninger, G. Fritz, 2013, Apoptosis.

αvβ3 Integrin-Mediated Drug Resistance in Human Laryngeal Carcinoma Cells Is Caused by Glutathione-Dependent Elimination of Drug-Induced Reactive Oxidative Species

D. Majhen, M. Osmak, G. Fritz, 2008, Molecular Pharmacology.

Targeting Mechanisms of the DNA Damage Response (DDR) and DNA Repair by Natural Compounds to Improve cAT-Triggered Tumor Cell Death

P. Proksch, G. Fritz, Jana Aengenvoort, 2022, Molecules.

Targeting the mevalonate pathway for improved anticancer therapy.

G. Fritz, 2009, Current cancer drug targets.

In Vitro Assessment of the Genotoxic Hazard of Novel Hydroxamic Acid- and Benzamide-Type Histone Deacetylase Inhibitors (HDACi)

W. Schulz, W. Roos, F. Hansen, 2020, International journal of molecular sciences.

The lipid lowering drug lovastatin protects against doxorubicin-induced hepatotoxicity.

K. Lackner, B. Kaina, C. Henninger, 2012, Toxicology and applied pharmacology.

Targeting the DNA damage response (DDR) by natural compounds.

P. Proksch, G. Fritz, Jana van Stuijvenberg, 2020, Bioorganic & medicinal chemistry.

Prevention of anticancer therapy-induced neurotoxicity: putting DNA damage in perspective.

G. Fritz, Vanessa Brinkmann, 2022, Neurotoxicology.

Phosphorylation of the DNA repair protein APE/REF-1 by CKII affects redox regulation of AP-1

B. Kaina, G. Fritz, 1999, Oncogene.

Comparative analysis of stress responses of H9c2 rat cardiomyoblasts following treatment with doxorubicin and tBOOH.

O. Issinger, G. Fritz, J. Hülsenbeck, 2012, Experimental cell research.

Identification of human genes involved in repair and tolerance of DNA damage

B. Kaina, G. Fritz, T. Coquerelle, 1991, Radiation and environmental biophysics.

Cytokine induction of NO synthase II in human DLD‐1 cells: roles of the JAK‐STAT, AP‐1 and NF‐κB‐signaling pathways

D. Geller, F. Rodríguez-Pascual, G. Fritz, 1998, British journal of pharmacology.

Cell and tissue-type specific expression of Ras-related GTPase RhoB.

B. Kaina, G. Fritz, R. Gnad, 1999, Anticancer research.

Nuclear RAC1 is a modulator of the doxorubicin-induced DNA damage response.

C. Henninger, G. Fritz, Rebekka Kitzinger, 2022, Biochimica et biophysica acta. Molecular cell research.

DNA damage response (DDR) induced by topoisomerase II poisons requires nuclear function of the small GTPase Rac.

C. Henninger, G. Fritz, F. Wartlick, 2013, Biochimica et biophysica acta.

Characterization of ATM and DNA-PK wild-type and mutant cell lines upon DSB induction in the presence and absence of CK2 inhibitors.

O. Issinger, G. Fritz, B. Olsen, 2011, International journal of oncology.

Anticancer drug and ionizing radiation-induced DNA damage differently influences transcription activity and DDR-related stress responses of an endothelial monolayer.

W. Roos, G. Fritz, L. Schumacher, 2020, Biochimica et biophysica acta. Molecular cell research.

Resistance of p53 knockout cells to doxorubicin is related to reduced formation of DNA strand breaks rather than impaired apoptotic signaling.

B. Kaina, T. Dunkern, G. Fritz, 2003, DNA repair.

Involvement of protein kinases in the induction of NO synthase II in human DLD‐1 cells

U. Förstermann, G. Fritz, H. Kleinert, 1998, British journal of pharmacology.

mESC-based in vitro differentiation models to study vascular response and functionality following genotoxic insults.

K. Gottmann, G. Fritz, M. Kassack, 2015, Toxicological sciences : an official journal of the Society of Toxicology.

Spongean alkaloids protect rat kidney cells against cisplatin-induced cytotoxicity

P. Proksch, J. Thomale, Katharina Krüger, 2014, Anti-cancer drugs.

Inducible Responses and Protective Functions of Mammalian Cells Upon Exposure to UV Light and Ionizing Radiation

S. Haas, B. Kaina, S. Mitra, 1999 .

Casein kinase II is elevated in solid human tumours and rapidly proliferating non-neoplastic tissue.

O. Issinger, H. R. Schneider, G. Fritz, 1990, European journal of biochemistry.

Nuclear expression of apurinic/apyrimidinic endonuclease increases with progression of ovarian carcinomas.

F. Oesch, H. Kölbl, J. Hengstler, 2004, Gynecologic oncology.

Tissue-specific variations in the expression and regulation of the small GTP-binding protein Rho.

I. Just, G. Fritz, P. Lang, 1994, Biochimica et biophysica acta.

Pleiotropic effects of spongean alkaloids on mechanisms of cell death, cell cycle progression and DNA damage response (DDR) of acute myeloid leukemia (AML) cells.

S. Wesselborg, P. Proksch, G. Fritz, 2015, Cancer letters.

Synthesis and biological evaluation of 4-nitro-substituted 1,3-diaryltriazenes as a novel class of potent antitumor agents.

I. Piantanida, M. Osmak, G. Fritz, 2011, European journal of medicinal chemistry.

Isolation and characterization of a Clostridium botulinum C2 toxin-resistant cell line: evidence for possible involvement of the cellular C2II receptor in growth regulation

P. Schroeder, K. Aktories, G. Fritz, 1995, Infection and immunity.

Differentiation-induced increase in Clostridium botulinum C3 exoenzyme-catalyzed ADP-ribosylation of the small GTP-binding protein Rho.

K. Aktories, I. Just, G. Fritz, 1994, European journal of biochemistry.

ADP-ribosylation of Rho proteins by Clostridium botulinum exoenzyme C3 is influenced by phosphorylation of Rho-associated factors.

K. Aktories, G. Fritz, 1994, The Biochemical journal.

Active site mutation of the C3-like ADP-ribosyltransferase from Clostridium limosum--analysis of glutamic acid 174.

K. Aktories, I. Just, P. Sehr, 1996, Biochemistry.

Upregulation of the immediate early gene product RhoB by exoenzyme C3 from Clostridium limosum and toxin B from Clostridium difficile.

I. Just, G. Fritz, R. Gerhard, 2007, Biochemistry.

Lovastatin protects keratinocytes from DNA damage-related pro-apoptotic stress responses stimulated by anticancer therapeutics.

G. Fritz, Verena Ziegler, Anne Albers, 2016, Biochimica et biophysica acta.

Lovastatin causes sensitization of HeLa cells to ionizing radiation‐induced apoptosis by the abrogation of G2 blockage

B. Kaina, G. Fritz, C. Brachetti, 2003, International journal of radiation biology.

Expression and cytoprotective activity of the small GTPase RhoB induced by the Escherichia coli cytotoxic necrotizing factor 1.

K. Rottner, I. Just, C. Brakebusch, 2013, The international journal of biochemistry & cell biology.

High-dose selection with mafosfamide results in sensitivity to DNA cross-linking agents: characterization of hypersensitive cell lines.

J. Hengstler, B. Kaina, G. Fritz, 1997, Cancer research.

Rac1-mediated cardiac damage causes diastolic dysfunction in a mouse model of subacute doxorubicin-induced cardiotoxicity

C. Henninger, G. Fritz, M. Kelm, 2017, Archives of Toxicology.

Inducibility of the DNA repair gene encoding O6-methylguanine-DNA methyltransferase in mammalian cells by DNA-damaging treatments

B. Kaina, S. Mitra, G. Fritz, 1991, Molecular and cellular biology.

Integrin αvβ3 expression in tongue squamous carcinoma cells Cal27 confers anticancer drug resistance through loss of pSrc(Y418).

D. Majhen, M. Bosnar, N. Stojanović, 2016, Biochimica et biophysica acta.

Long‐term activation of SAPK/JNK, p38 kinase and fas‐L expression by cisplatin is attenuated in human carcinoma cells that acquired drug resistance

M. Christmann, B. Kaina, J. Zisowsky, 2004, International journal of cancer.

Contribution of O6‐alkylguanine and N‐alkylpurines to the formation of sister chromatid exchanges, chromosomal aberrations, and gene mutations: New insights gained from studies of genetically engineered mammalian cell lines

B. Kaina, G. Fritz, T. Coquerelle, 1993, Environmental and molecular mutagenesis.

DNA Damage Response in Neonatal and Adult Stromal Cells Compared With Induced Pluripotent Stem Cells

H. Zaehres, G. Fritz, S. Liedtke, 2015, Stem cells translational medicine.

Cell-Based Drug Development , Screening , and Toxicology DNA Damage Response in Neonatal and Adult Stromal Cells Compared With Induced Pluripotent Stem Cells

H. Zaehres, G. Fritz, S. Liedtke, 2015 .

Selectivity analysis of protein kinase CK2 inhibitors DMAT, TBB and resorufin in cisplatin-induced stress responses.

O. Issinger, G. Fritz, B. Olsen, 2009, International journal of oncology.

B. Kaina, G. Fritz, 2001, The Journal of biological chemistry.

TSG (2,3,5,4′-Tetrahydroxystilbene-2-O-β-D-glucoside) from the Chinese Herb Polygonum multiflorum Increases Life Span and Stress Resistance of Caenorhabditis elegans

P. Proksch, Liang Zhao, G. Fritz, 2015, Oxidative medicine and cellular longevity.

Statins in anthracycline-induced cardiotoxicity: Rac and Rho, and the heartbreakers

C. Henninger, G. Fritz, 2017, Cell Death & Disease.

Stress factors affecting expression of O6-methylguanine-DNA methyltransferase mRNA in rat hepatoma cells.

B. Kaina, G. Fritz, 1992, Biochimica et biophysica acta.

Transfection and expression of human O6-methylguanine-DNA methyltransferase (MGMT) cDNA in Chinese hamster cells: the role of MGMT in protection against the genotoxic effects of alkylating agents.

B. Kaina, S. Mitra, G. Fritz, 1991, Carcinogenesis.

Rho inhibition by lovastatin affects apoptosis and DSB repair of primary human lung cells in vitro and lung tissue in vivo following fractionated irradiation

M. Ahmadian, C. Henninger, G. Fritz, 2017, Cell Death & Disease.

HMG-CoA reductase inhibitors (statins) as anticancer drugs (review).

G. Fritz, 2005, International journal of oncology.

CD28-dependent Rac1 activation is the molecular target of azathioprine in primary human CD4+ T lymphocytes.

M. Neurath, P. Galle, H. Lehr, 2003, The Journal of clinical investigation.

B. Kaina, G. Fritz, 2000, Biochemical and biophysical research communications.

Multiple DNA damage-dependent and DNA damage-independent stress responses define the outcome of ATR/Chk1 targeting in medulloblastoma cells.

W. Roos, S. Wesselborg, M. Remke, 2018, Cancer letters.

Class I HDAC overexpression promotes temozolomide resistance in glioma cells by regulating RAD18 expression

Ella L. Kim, T. Hofmann, W. Roos, 2022, Cell Death & Disease.

Premature senescence is a primary fail-safe mechanism of ERBB2-driven tumorigenesis in breast carcinoma cells.

Jan G Hengstler, Peter Schmidtke, Steffen Schmitt, 2005, Cancer research.

Rac1 promotes diethylnitrosamine (DEN)-induced formation of liver tumors.

M. Schwarz, B. Kaina, C. Henninger, 2015, Carcinogenesis.

Rac1 modulates acute and subacute genotoxin-induced hepatic stress responses, fibrosis and liver aging

B. Kaina, C. Henninger, G. Fritz, 2013, Cell Death and Disease.

Late Activation of Stress-activated Protein Kinases/c-Jun N-terminal Kinases Triggered by Cisplatin-induced DNA Damage in Repair-defective Cells*

B. Kaina, B. Köberle, M. Osmak, 2011, The Journal of Biological Chemistry.

Rho GTPases in human breast tumours: expression and mutation analyses and correlation with clinical parameters

B. Kaina, M. Schmidt, G. Fritz, 2002, British Journal of Cancer.

Fatal Lymphoproliferative Disease in Two Siblings Lacking Functional FAAP24

A. Borkhardt, B. Kempkes, B. Fleckenstein, 2016, Journal of Clinical Immunology.

Cytoprotective effect of the small GTPase RhoB expressed upon treatment of fibroblasts with the Ras‐glucosylating Clostridium sordellii lethal toxin

M. Hohenegger, I. Just, G. Fritz, 2012, FEBS letters.

Progression of breast tumors is accompanied by a decrease in expression of the Rho guanine exchange factor Tiam1.

M. Schmidt, M. Kunkel, G. Fritz, 2009, Oncology reports.

rhoB Encoding a UV-inducible Ras-related Small GTP-binding Protein Is Regulated by GTPases of the Rho Family and Independent of JNK, ERK, and p38 MAP Kinase*

B. Kaina, G. Fritz, 1997, The Journal of Biological Chemistry.

B. Kaina, K. Aktories, G. Fritz, 1995, The Journal of Biological Chemistry.

Intrinsic anticancer drug resistance of malignant melanoma cells is abrogated by IFN-β and valproic acid.

B. Kaina, W. Roos, G. Fritz, 2011, Cancer research.

Induction of DNA Repair Genes in Mammalian Cells in Response to Genotoxic Stress

M. Christmann, B. Kaina, G. Fritz, 2006 .

Genomic differences between O6-methylguanine-DNA methyltransferase proficient (Mex+) and deficient (Mex-) cell lines: possible role of genetic and epigenetic changes in conversion of Mex+ into Mex-.

B. Kaina, G. Fritz, 1992, Biochemical and biophysical research communications.

Downregulation of RhoB GTPase confers resistance to cisplatin in human laryngeal carcinoma cells.

M. Osmak, G. Fritz, N. Mikac, 2010, Cancer letters.

Phenotype plasticity rather than repopulation from CD90/CK14+ cancer stem cells leads to cisplatin resistance of urothelial carcinoma cell lines

P. Albers, A. Romano, W. Schulz, 2015, Journal of experimental & clinical cancer research : CR.

Lack of the catalytic subunit of DNA-dependent protein kinase (DNA-PKcs) is accompanied by increased CK2α′ levels

U. Fischer, E. Meese, O. Issinger, 2011, Molecular and Cellular Biochemistry.

Rac1 signaling protects monocytic AML cells expressing the MLL-AF9 oncogene from caspase-mediated apoptotic death

B. Kaina, C. Henninger, G. Fritz, 2013, Apoptosis.

Inhibition of Rac1 signaling by lovastatin protects against anthracycline-induced cardiac toxicity

K. Lackner, B. Kaina, C. Henninger, 2011, Cell Death and Disease.

Chronic heart damage following doxorubicin treatment is alleviated by lovastatin.

C. Henninger, G. Fritz, P. Wenzel, 2015, Pharmacological research.

Lovastatin protects human endothelial cells from the genotoxic and cytotoxic effects of the anticancer drugs doxorubicin and etoposide

B. Kaina, B. Epe, W. Roos, 2006, British journal of pharmacology.

Endoplasmic Reticulum Stress Is Involved in the Response of Human Laryngeal Carcinoma Cells to Carboplatin but Is Absent in Carboplatin-Resistant Cells

I. Arany, D. Majhen, B. Köberle, 2013, PloS one.

Lovastatin Protects Human Endothelial Cells from Killing by Ionizing Radiation without Impairing Induction and Repair of DNA Double-Strand Breaks

B. Kaina, W. Roos, G. Fritz, 2006, Clinical Cancer Research.

CD 28-dependent Rac 1 activation is the molecular target of azathioprine in primary human CD 4 + T lymphocytes

M. Neurath, P. Galle, H. Lehr, 2003 .

Designer Thiopurine-analogues for Optimised Immunosuppression in Inflammatory Bowel Diseases.

U. Hofmann, M. Neurath, R. Atreya, 2016, Journal of Crohn's & colitis.

Hepatic Rac1 GTPase contributes to liver-mediated basal immune homeostasis and LPS-induced endotoxemia.

S. Scheu, C. Henninger, G. Fritz, 2018, Biochimica et biophysica acta. Molecular cell research.

Lovastatin prevents cisplatin-induced activation of pro-apoptotic DNA damage response (DDR) of renal tubular epithelial cells.

J. Thomale, Katharina Krüger, C. Henninger, 2016, Toxicology and applied pharmacology.

Rho GTPases: Novel Players in the Regulation of the DNA Damage Response?

C. Henninger, G. Fritz, 2015, Biomolecules.

Rac1 Protein Signaling Is Required for DNA Damage Response Stimulated by Topoisomerase II Poisons*

B. Kaina, W. Roos, C. Henninger, 2012, The Journal of Biological Chemistry.

Mevalonate pathway inhibitors affect anticancer drug-induced cell death and DNA damage response of human sarcoma cells.

S. Nilsson, G. Fritz, J. Huelsenbeck, 2011, Cancer letters.

DNA replication arrest in response to genotoxic stress provokes early activation of stress-activated protein kinases (SAPK/JNK).

B. Kaina, W. Roos, G. Fritz, 2009, Journal of molecular biology.

Late activation of stress kinases (SAPK/JNK) by genotoxins requires the DNA repair proteins DNA-PKcs and CSB.

B. Kaina, G. Fritz, 2005, Molecular biology of the cell.

B. Kaina, G. Fritz, 2001, The Journal of Biological Chemistry.

Apurinic endonuclease (Ref-1) is induced in mammalian cells by oxidative stress and involved in clastogenic adaptation.

B. Kaina, G. Fritz, S. Grösch, 1998, Cancer research.

Ionizing radiation-induced E-selectin gene expression and tumor cell adhesion is inhibited by lovastatin and all-trans retinoic acid.

B. Kaina, W. Dippold, G. Fritz, 2004, Carcinogenesis.

Cisplatin-induced apoptosis in 43-3B and 27-1 cells defective in nucleotide excision repair.

B. Kaina, T. Dunkern, G. Fritz, 2001, Mutation research.

Rac1-Regulated Endothelial Radiation Response Stimulates Extravasation and Metastasis That Can Be Blocked by HMG-CoA Reductase Inhibitors

S. Wirtz, B. Kaina, G. Fritz, 2011, PloS one.

APE/Ref-1 and the mammalian response to genotoxic stress.

M. Tomicic, B. Kaina, G. Fritz, 2003, Toxicology.

Human primary endothelial cells are impaired in nucleotide excision repair and sensitive to benzo[a]pyrene compared with smooth muscle cells and pericytes

A. Izzotti, B. Kaina, G. Fritz, 2019, Scientific Reports.

Clostridium difficile Toxin A Induces Expression of the Stress-induced Early Gene Product RhoB*

I. Just, T. Thum, G. Fritz, 2005, Journal of Biological Chemistry.

Lovastatin inhibits Rho‐regulated expression of E‐selectin by TNF‐α and attenuates tumor cell adhesion

B. Kaina, W. Dippold, G. Fritz, 2004, FASEB journal : official publication of the Federation of American Societies for Experimental Biology.

Cisplatin-induced neurotoxicity involves the disruption of serotonergic neurotransmission.

N. Ventura, J. Bornhorst, G. Fritz, 2021, Pharmacological research.

Parental sex allocation and sex-specific survival drive offspring sex ratio bias in little owls

J. Fattebert, M. Grüebler, B. Naef-Daenzer, 2019, Behavioral Ecology and Sociobiology.

Distinct influence of the anthracycline derivative doxorubicin on the differentiation efficacy of mESC-derived endothelial progenitor cells.

A. Reichert, G. Fritz, M. Kassack, 2020, Biochimica et biophysica acta. Molecular cell research.

Overexpression of GLUT-1 is associated with resistance to radiotherapy and adverse prognosis in squamous cell carcinoma of the oral cavity.

H. Lehr, T. Whiteside, Jong-Hyeon Jeong, 2007, Oral oncology.

Transgenic systems in studies on genotoxicity of alkylating agents: critical lesions, thresholds and defense mechanisms.

S. Haas, B. Kaina, P. Lund, 1998, Mutation research.

Kaina by Oxidative Stress and Involved in Clastogenic Adaptation Apurinic Endonuclease ( Ref-1 ) Is Induced in Mammalian Cells

G. Fritz, S. Grösch, Bernd, 2006 .

Transfer of Genes Affecting Resistance of Mammalian Cells to Alkylating Drugs — Implications for Cancer Chemotherapy

B. Kaina, G. Fritz, E. Eschbach, 1995 .

Cytolethal distending toxin (CDT) is a radiomimetic agent and induces persistent levels of DNA double-strand breaks in human fibroblasts.

B. Kaina, W. Roos, T. Frisan, 2014, DNA repair.

Complementation of N-hydroxyethyl-N-chloroethylnitrosourea hypersensitivity of Mex- cells by microinjection of mRNA from Mex+ cells.

B. Kaina, H. Rahmsdorf, G. Fritz, 1990, Mutation research.

Inhibition of Rho modulates cytokine-induced prostaglandin E2 formation in renal mesangial cells.

J. Pfeilschifter, A. Huwiler, G. Fritz, 2004, Biochimica et biophysica acta.

Studies on the active-site structure of C3-like exoenzymes: involvement of glutamic acid in catalysis of ADP-ribosylation.

J. Vandekerckhove, K. Aktories, I. Just, 1995, Biochimie.

The HMG-CoA reductase inhibitor lovastatin protects cells from the antineoplastic drugs doxorubicin and etoposide.

B. Kaina, T. Dunkern, G. Fritz, 2002, International Journal of Molecular Medicine.

Effect of transfection of human poly(ADP-ribose)polymerase in Chinese hamster cells on mutagen resistance.

B. Kaina, B. Auer, G. Fritz, 1994, Mutation research.

Myricetin-Mediated Lifespan Extension in Caenorhabditis elegans Is Modulated by DAF-16

G. Fritz, D. Ackermann, W. Wätjen, 2013, International journal of molecular sciences.

Distinct contribution of Rac1 expression in cardiomyocytes to anthracycline-induced cardiac injury.

J. Schmitt, C. Henninger, G. Fritz, 2019, Biochemical pharmacology.

Effects of Manganese on Genomic Integrity in the Multicellular Model Organism Caenorhabditis elegans

M. Aschner, T. Schwerdtle, J. Bornhorst, 2021, International journal of molecular sciences.

Distinct mechanisms contribute to acquired cisplatin resistance of urothelial carcinoma cells

W. Schulz, M. Skowron, G. Niegisch, 2016, Oncotarget.

Statins Induce a DAF-16/Foxo-dependent Longevity Phenotype via JNK-1 through Mevalonate Depletion in C. elegans

G. Fritz, A. Jahn, S. Honnen, 2020, Aging and disease.

Proteasomal Degradation of Cytotoxic Necrotizing Factor 1-Activated Rac

K. Aktories, G. Fritz, M. Pop, 2002, Infection and Immunity.

Rho GTPases are involved in the regulation of NF-kappaB by genotoxic stress.

B. Kaina, G. Fritz, R. Gnad, 2001, Experimental cell research.

Profiling of a suramin-derived compound library at recombinant human P2Y receptors identifies NF272 as a competitive but non-selective P2Y2 receptor antagonist

G. Fritz, A. Hamacher, M. Kassack, 2019, Purinergic Signalling.

Potential use of HMG-CoA reductase inhibitors (statins) as radioprotective agents.

C. Henninger, G. Fritz, J. Huelsenbeck, 2011, British medical bulletin.

Werner syndrome (WRN) DNA helicase and base excision repair (BER) factors maintain endothelial homeostasis.

B. Kaina, G. Fritz, Kathrin Laarmann, 2019, DNA repair.

Use of C. elegans as a 3R-compliant in vivo model for the chemoprevention of cisplatin-induced neurotoxicity

U. Karst, J. Bornhorst, G. Fritz, 2021, Experimental Neurology.

Inhibition of the DSB repair protein RAD51 potentiates the cytotoxic efficacy of doxorubicin via promoting apoptosis-related death pathways.

G. Fritz, A. Brozovic, L. Schumacher, 2021, Cancer Letters.

Proteasomal Degradation of Cytotoxic Necrotizing Factor

K. Aktories, G. Fritz, M. Pop, 2002 .