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Imaging , Diagnosis , Prognosis Effect of TP 53 Arg 72 Pro and MDM 2 SNP 309 Polymorphisms on the Risk of High-Grade Osteosarcoma Development and Survival

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Preferential expression of RB1-inducible coiled-coil 1 in terminal differentiated musculoskeletal cells.

M. Serra, H. Okabe, T. Chano, 2002, The American journal of pathology.

LSAMP, a novel candidate tumor suppressor gene in human osteosarcomas, identified by array comparative genomic hybridization

Stine H. Kresse, O. Myklebost, L. Meza-Zepeda, 2009, Genes, chromosomes & cancer.

Clinicopathological significance of cell cycle regulation markers in a large series of genetically confirmed Ewing's Sarcoma Family of Tumors

A. Llombart‐Bosch, P. Picci, A. Pellín, 2011, International journal of cancer.

Imputation and subset-based association analysis across different cancer types identifies multiple independent risk loci in the TERT-CLPTM1L region on chromosome 5p15.33.

William Wheeler, Hideo Tanaka, Jianxin Shi, 2014, Human molecular genetics.

Targeting CDKs with Roscovitine Increases Sensitivity to DNA Damaging Drugs of Human Osteosarcoma Cells

R. Versteeg, J. Koster, P. Picci, 2016, PloS one.

Integrins in glioblastoma: Still an attractive target?

M. Serra, M. Paolillo, S. Schinelli, 2016, Pharmacological research.

Current understanding of pharmacogenetic implications of DNA damaging drugs used in osteosarcoma treatment

P. Picci, C. Hattinger, M. Serra, 2019, Expert opinion on drug metabolism & toxicology.

Stem-Like Cancer Cells in a Dynamic 3D Culture System: A Model to Study Metastatic Cell Adhesion and Anti-Cancer Drugs

L. Belvisi, S. Comincini, M. Serra, 2019, Cells.

An aza-macrocycle containing maltolic side-arms (maltonis) as potential drug against human pediatric sarcomas

P. Lollini, P. Picci, M. Magnani, 2014, BMC Cancer.

ABCA1/ABCB1 Ratio Determines Chemo- and Immune-Sensitivity in Human Osteosarcoma

G. De Rosa, M. Donadelli, D. Belisario, 2020, Cells.

Effect of TP53 Arg72Pro and MDM2 SNP309 Polymorphisms on the Risk of High-Grade Osteosarcoma Development and Survival

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Prognostic Value of CCN3 in Osteosarcoma

P. Picci, K. Scotlandi, M. Serra, 2008, Clinical Cancer Research.

CD99 acts as an oncosuppressor in osteosarcoma.

P. Lollini, M. Colombo, P. Picci, 2006, Molecular biology of the cell.

Expression of Met/hepatocyte growth factor receptor gene and malignant behavior of musculoskeletal tumors.

M. Oliviero, P. Comoglio, N. Baldini, 1996, The American journal of pathology.

P‐glycoprotein expression in osteosarcoma: A basis for risk‐adapted adjuvant chemotherapy

P. Picci, G. Bacci, N. Baldini, 1999, Journal of orthopaedic research : official publication of the Orthopaedic Research Society.

A small-molecule RGD-integrin antagonist inhibits cell adhesion, cell migration and induces anoikis in glioblastoma cells

M. Serra, M. Paolillo, D. Curti, 2012, International journal of oncology.

Copy number alterations and neoplasia‐specific mutations in MELK, PDCD1LG2, TLN1, and PAX5 at 9p in different neoplasias

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Alendronate Reduces Adhesion of Human Osteoclast-like Cells to Bone and Bone Protein-Coated Surfaces

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Candidate germline polymorphisms of genes belonging to the pathways of four drugs used in osteosarcoma standard chemotherapy associated with risk, survival and toxicity in non-metastatic high-grade osteosarcoma

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Adriamycin binding assay: a valuable chemosensitivity test in human osteosarcoma

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Genetic imbalances in 67 synovial sarcomas evaluated by comparative genomic hybridization

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Establishment and characterization of a primitive neuroectodermal tumor of bone continuous cell line (LAP-35).

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Amplification of CDK4, MDM2, SAS and GLI genes in leiomyosarcoma, alveolar and embryonal rhabdomyosarcoma.

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Relationship between P-glycoprotein expression and p53 status in high-grade osteosarcoma.

P. Picci, D. Maurici, F. Bertoni, 1999, International journal of oncology.

Pharmacogenomics of second-line drugs used for treatment of unresponsive or relapsed osteosarcoma patients.

P. Picci, C. Hattinger, M. Serra, 2016, Pharmacogenomics.

Genomic imbalances associated with secondary acute leukemias in Hodgkin lymphoma.

G. Castellani, S. Pileri, P. Zinzani, 2007, Oncology reports.

Different simian virus 40 genomic regions and sequences homologous with SV40 large T antigen in DNA of human brain and bone tumors and of leukocytes from blood donors

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Small molecule integrin antagonists in cancer therapy.

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Identification of markers of possible prognostic value in 57 giant cell tumors of bone.

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Differentially expressed genes in multidrug resistant variants of U-2 OS human osteosarcoma cells.

P. Picci, N. Baldini, K. Scotlandi, 2004, Oncology reports.

Hyaluronated liposomes containing H2S-releasing doxorubicin are effective against P-glycoprotein-positive/doxorubicin-resistant osteosarcoma cells and xenografts.

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Endoplasmic reticulum-targeting doxorubicin: a new tool effective against doxorubicin-resistant osteosarcoma

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Targeting polo-like kinase 1 by NMS-P937 in osteosarcoma cell lines inhibits tumor cell growth and partially overcomes drug resistance

R. Versteeg, P. Picci, C. Hattinger, 2014, Investigational New Drugs.

Preclinical validation of Aurora kinases-targeting drugs in osteosarcoma

R. Versteeg, P. Picci, C. Hattinger, 2013, British Journal of Cancer.

Giant Cell Tumor of Bone: A Model for the in Vitro Human Osteoclast Characterization

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Evaluation of osteonectin as a diagnostic marker of osteogenic bone tumors.

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Value of P-glycoprotein and clinicopathologic factors as the basis for new treatment strategies in high-grade osteosarcoma of the extremities.

S. Ferrari, P. Picci, F. Bertoni, 2003, Journal of clinical oncology : official journal of the American Society of Clinical Oncology.

Reversal of malignant phenotype in human osteosarcoma cells transduced with the alkaline phosphatase gene.

P. Lollini, P. Picci, D. Maurici, 2000, Bone.

Clinical relevance of Ki‐67 expression in bone tumors

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Redundancy of autocrine loops in human osteosarcoma cells

P. Lollini, P. Picci, N. Baldini, 1999, International journal of cancer.

Impact of ABC Transporters in Osteosarcoma and Ewing’s Sarcoma: Which Are Involved in Chemoresistance and Which Are Not?

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Characterization of Water-Soluble Esters of Nitrobenzoxadiazole-Based GSTP1-1 Inhibitors for Cancer Treatment.

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Endoplasmic reticulum-targeting doxorubicin: a new tool effective against doxorubicin-resistant osteosarcoma

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ABCA6 affects the malignancy of Ewing sarcoma cells via cholesterol-guided inhibition of the IGF1R/AKT/MDM2 axis

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Doxorubicin-resistant osteosarcoma: novel therapeutic approaches in sight?

P. Picci, C. Riganti, C. Hattinger, 2017, Future oncology.

Insulin-like growth factor I receptor-mediated circuit in Ewing's sarcoma/peripheral neuroectodermal tumor: a possible therapeutic target.

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Long-Term Follow-up of a Randomized Study of Oral Etoposide versus Viscum album Fermentatum Pini as Maintenance Therapy in Osteosarcoma Patients in Complete Surgical Remission after Second Relapse

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Prenylated Curcumin Analogues as Multipotent Tools To Tackle Alzheimer's Disease.

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Drug Resistance in Osteosarcoma: Emerging Biomarkers, Therapeutic Targets and Treatment Strategies

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Mitochondria-Targeted Doxorubicin: A New Therapeutic Strategy against Doxorubicin-Resistant Osteosarcoma

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Array comparative genomic hybridization reveals frequent alterations of G1/S checkpoint genes in undifferentiated pleomorphic sarcoma of bone

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miR‐34a predicts survival of Ewing's sarcoma patients and directly influences cell chemo‐sensitivity and malignancy

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Kinome and mRNA expression profiling of high-grade osteosarcoma cell lines implies Akt signaling as possible target for therapy

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EWS-erg and EWS-Fli1 fusion transcripts in Ewing's sarcoma and primitive neuroectodermal tumors with variant translocations.

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An update on emerging drugs in osteosarcoma: towards tailored therapies?

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Pharmacogenomics and Pharmacogenetics in Osteosarcoma: Translational Studies and Clinical Impact

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Mechanisms of gene amplification and evidence of coamplification in drug‐resistant human osteosarcoma cell lines

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Targeting ABCB1 and ABCC1 with their Specific Inhibitor CBT-1® can Overcome Drug Resistance in Osteosarcoma.

P. Picci, C. Hattinger, M. Serra, 2016, Current cancer drug targets.

Genome‐wide association study identifies the GLDC/IL33 locus associated with survival of osteosarcoma patients

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Prognostic Significance of Nuclear Accumulation of c-myc and mdm2 Proteins in Synovial Sarcoma of the Extremities

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Identification of EWS/FLI‐1 transcripts in giant‐cell tumor of bone

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Emerging drugs for high-grade osteosarcoma

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Analysis of Heritability and Shared Heritability Based on Genome-Wide Association Studies for Thirteen Cancer Types.

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Genomic imbalances associated with methotrexate resistance in human osteosarcoma cell lines detected by comparative genomic hybridization-based techniques.

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Value of immunohistochemical detection of noncollagenous proteins of bone for the diagnosis of bone tumours.

P. Picci, D. Maurici, F. Bertoni, 1996, International journal of oncology.

Prognostic and therapeutic targets in the Ewing's family of tumors (PROTHETS).

P. Picci, K. Scotlandi, M. Serra, 2006, Advances in experimental medicine and biology.

In Ewing's sarcoma CCN3(NOV) inhibits proliferation while promoting migration and invasion of the same cell type

M. Colombo, P. Picci, K. Scotlandi, 2005, Oncogene.

The expression of ccn3(nov) gene in musculoskeletal tumors.

P. Picci, F. Bertoni, H. Yeger, 2002, The American journal of pathology.

Effectiveness of insulin-like growth factor I receptor antisense strategy against Ewing's sarcoma cells

P. Lollini, P. Picci, N. Baldini, 2002, Cancer Gene Therapy.

Molecular characterization of commonly used cell lines for bone tumor research: A trans‐European EuroBoNet effort

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Multidrug resistance and malignancy in human osteosarcoma.

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A Genome-Wide Scan Identifies Variants in NFIB Associated with Metastasis in Patients with Osteosarcoma.

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Contribution of MEK/MAPK and PI3‐K signaling pathway to the malignant behavior of Ewing's sarcoma cells: Therapeutic prospects

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Simultaneous Paired Analysis of Numerical Chromosomal Aberrations and DNA Content in Osteosarcoma

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4-Demethoxy-3'-deamino-3'-aziridinyl-4'-methylsulphonyl-daunorubicin (PNU-159548): a promising new candidate for chemotherapeutic treatment of osteosarcoma patients.

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Genetic testing for high-grade osteosarcoma: a guide for future tailored treatments?

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Pre‐Treatment of human osteosarcoma cells with N‐methylformamide enhances P‐glycoprotein expression and resistance to doxorubicin

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Role of pharmacogenetics of drug-metabolizing enzymes in treating osteosarcoma

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An update on chemotherapy for osteosarcoma

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Small Nucleolar RNAs Determine Resistance to Doxorubicin in Human Osteosarcoma

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Caveolins in the development and diseases of musculoskeletal system.

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c-kit Receptor E xpression i n E wing's S arcoma: L ack o f Prognostic V alue b ut T herapeutic T argeting O pportunities i n Appropriate C onditions

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CD99 engagement: an effective therapeutic strategy for Ewing tumors.

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IR/IGF1R signaling as potential target for treatment of high-grade osteosarcoma

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The fine-tuning of TRAF2–GSTP1-1 interaction: effect of ligand binding and in situ detection of the complex

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Expression of an IGF‐I receptor dominant negative mutant induces apoptosis, inhibits tumorigenesis and enhances chemosensitivity in Ewing's sarcoma cells

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Cisplatin Resistance in Osteosarcoma: In vitro Validation of Candidate DNA Repair-Related Therapeutic Targets and Drugs for Tailored Treatments

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Silk Fibroin Nanoparticle Functionalization with Arg-Gly-Asp Cyclopentapeptide Promotes Active Targeting for Tumor Site-Specific Delivery

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Anti-EGFR Antibody Cetuximab Enhances the Cytolytic Activity of Natural Killer Cells toward Osteosarcoma

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H2S-Donating Doxorubicins May Overcome Cardiotoxicity and Multidrug Resistance.

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Pharmacogenomic Profiling of Cisplatin-Resistant and -Sensitive Human Osteosarcoma Cell Lines by Multimodal Targeted Next Generation Sequencing

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SARG: a new human osteosarcoma cell line. Expression of bone markers and of major histocompatibility antigens.

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Caveolin-1 reduces osteosarcoma metastases by inhibiting c-Src activity and met signaling.

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Integrative Analysis Reveals Relationships of Genetic and Epigenetic Alterations in Osteosarcoma

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Clinical impact of the methotrexate resistance-associated genes C-MYC and dihydrofolate reductase (DHFR) in high-grade osteosarcoma.

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An RGD small-molecule integrin antagonist induces detachment-mediated anoikis in glioma cancer stem cells.

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Molecular profiling of chordoma

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Molecular characterization of commonly used cell lines for bone tumor research: A trans‐European EuroBoNet effort

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Caveolins in the development and diseases of musculoskeletal system.

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Overcoming glutathione S-transferase P1-related cisplatin resistance in osteosarcoma.

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Establishment and characterization of in vivo orthotopic bioluminescent xenograft models from human osteosarcoma cell lines in Swiss nude and NSG mice

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