S. Metz

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p53-independent induction of p21waf1/cip1 contributes to the activation of caspases in GTP-depletion-induced apoptosis of insulin-secreting cells

J. Huo, S. Metz, G. Li, 2004, Cell Death and Differentiation.

The Pancreatic Islet as Rubik's Cube: Is Phospholipid Hydrolysis a piece of the Puzzle?

S. Metz, 1991, Diabetes.

Gene expression of type I phospholipase A2 in pancreatic beta cells

R. Robertson, B. Draznin, W. Leitner, 1991, FEBS letters.

Autonomic epilepsy: clonidine blockade of paroxysmal catecholamine release and flushing.

J. Halter, D. Porte, R. Robertson, 1978, Annals of internal medicine.

Rebound hypertension after discontinuation of transdermal clonidine therapy.

S. Metz, C. Klein, N. Morton, 1987, The American journal of medicine.

Paradoxical inhibition of insulin secretion by glucose in human diabetes mellitus.

J. Halter, R. Robertson, S. Metz, 1979, The Journal of clinical endocrinology and metabolism.

Selective deficiency of 1,25-dihydroxycholecalciferol. A cause of isolated skeletal resistance to parathyroid hormone.

M. Haussler, R. Robertson, S. Metz, 1977, The New England journal of medicine.

Activation of caspase-2 mediates the apoptosis induced by GTP-depletion in insulin-secreting (HIT-T15) cells.

S. Metz, R. Luo, Guodong Li, 2002, Endocrinology.

Effects of inhibitors of guanine nucleotide synthesis on membrane potential and cytosolic free Ca2+ levels in insulin-secreting cells.

S. Metz, G. Li, R. Luo, 2000, Biochemical pharmacology.

Prolonged depletion of guanosine triphosphate induces death of insulin-secreting cells by apoptosis.

M. Rabaglia, A. Kowluru, S. Metz, 1998, Endocrinology.

Inhibition of calcium-induced insulin secretion from intact HIT-T15 or INS-1 beta cells by GTP depletion.

S. Metz, G. Li, M. Meredith, 1997, Biochemical pharmacology.

Blockade by lipoxygenase inhibitors of Ca2+-dependent insulin secretion from permeabilized rat islets. A molecular mechanism distinct from that of alpha 2-adrenergic agonists.

S. Metz, 1989, Biochemical pharmacology.

Altered arachidonic acid synthesis and lipid peroxidation in diabetes mellitus: possible roles in leukocyte dysfunction and other cellular defects.

S. Metz, 1983, Medical hypotheses.

Neuroendocrine modulation of calcitonin and parathyroid hormone in man.

R. Robertson, L. Deftos, S. Metz, 1978, The Journal of clinical endocrinology and metabolism.

Inosine-5'-Monophosphate Dehydrogenase Is Required for Mitogenic Competence of Transformed Pancreatic β Cells* * This work was supported in part by NIH Grant DK-37312.

M. Rabaglia, J. Brockenbrough, S. Metz, 2001, Endocrinology.

Modulation of insulin secretion by cyclic AMP and prostaglandin E: the effects of theophylline, sodium salicylate and tolbutamide.

R. Robertson, W. Fujimoto, S. Metz, 1982, Metabolism: clinical and experimental.

Arachidonic acid and its metabolites: evolving roles as transmembrane signals for insulin release.

S. Metz, 1988, Prostaglandins, leukotrienes, and essential fatty acids.

Prostaglandins, the Glucoreceptor, and Diabetes

S. Metz, Robertson Rp, 1979 .

Lipoxygenase pathway in islet endocrine cells. Oxidative metabolism of arachidonic acid promotes insulin release.

R. Robertson, W. Fujimoto, R. Strife, 1983, The Journal of clinical investigation.

Oxygenation products of arachidonic acid: third messengers for insulin release.

R. Robertson, W. Fujimoto, S. Metz, 1984, The Journal of allergy and clinical immunology.

A role for endogenous prostaglandins in defective glucose potentiation of nonglucose insulin secretagogues in diabetics.

R. Robertson, S. Metz, J. McRae, 1981, Metabolism: clinical and experimental.

Prostaglandin synthesis inhibitors reverse alpha-adrenergic inhibition of acute insulin response to glucose.

R. Robertson, S. Metz, 1980, The American journal of physiology.

Hypothesis: prostaglandins mediate defective glucose recognition in diabetes mellitus.

R. Robertson, S. Metz, J. McRae, 1980, Prostaglandins and medicine.

Improvement of insulin secretion in diabetics by a prostaglandin synthesis inhibitor.

R. Robertson, S. Metz, M. Chen, 1979, Advances in experimental medicine and biology.

Cyclosporin-induced inhibition of insulin release. Possible role of voltage-dependent calcium transport channels.

B. Draznin, J. Leitner, S. Metz, 1988, Biochemical pharmacology.

Modulation of insulin secretion from normal rat islets by inhibitors of the post-translational modifications of GTP-binding proteins.

J. Stock, M. Rabaglia, A. Kowluru, 1993, The Biochemical journal.

Glucose activates the carboxyl methylation of gamma subunits of trimeric GTP-binding proteins in pancreatic beta cells. Modulation in vivo by calcium, GTP, and pertussis toxin.

A. Kowluru, S. Metz, G. Li, 1997, The Journal of clinical investigation.

Roles of Phospholipids and Phospholipase Activation in P-Cell Function

S. Metz, 1999 .

Subcellular localization and kinetic characterization of guanine nucleotide binding proteins in normal rat and human pancreatic islets and transformed beta cells.

M. Rabaglia, A. Kowluru, S. Metz, 1994, Biochimica et biophysica acta.

Glyburide increases cytosolic-free calcium concentrations in normal rat pancreatic islet cells.

B. Draznin, J. Leitner, S. Metz, 1988, Metabolism: clinical and experimental.

Clonidine-suppression test for diagnosis of pheochromocytoma.

J. Halter, Morris J. Brown, J. C. Beard, 1982, The New England journal of medicine.

Role for GTP in glucose-induced phospholipase C activation in pancreatic islets.

M. Rabaglia, S. Metz, J. Vadakekalam, 1996, The American journal of physiology.

Use of a soluble tetrazolium compound to assay metabolic activation of intact beta cells.

S. Metz, G. Li, V. Segu, 1998, Metabolism: clinical and experimental.

Stimulation of insulin release by phospholipase D. A potential role for endogenous phosphatidic acid in pancreatic islet function.

S. Metz, M. Dunlop, 1990, The Biochemical journal.

Ether-Linked Lysophospholipids Initiate Insulin Secretion: Lysophospholipids May Mediate Effects of Phospholipase A2 Activation on Hormone Release

S. Metz, 1986, Diabetes.

Role of tissue transglutaminase in GTP depletion-induced apoptosis of insulin-secreting (HIT-T15) cells.

S. Metz, Guodong Li, Jianxin Huo, 2003, Biochemical pharmacology.

Carboxylmethylation of the catalytic subunit of protein phosphatase 2A in insulin-secreting cells: evidence for functional consequences on enzyme activity and insulin secretion.

M. Rabaglia, S. Seavey, A. Kowluru, 1996, Endocrinology.

Effects of clonidine on hormone and substrate responses to hypoglycemia

J. Halter, S. Metz, 1980, Clinical pharmacology and therapeutics.

Sodium salicylate potentiates neurohumoral responses to insulin-induced hypoglycemia.

J. Halter, R. Robertson, S. Metz, 1980, The Journal of clinical endocrinology and metabolism.

Inhibition of Prostaglandin E Synthesis Augments Glucose-induced Insulin Secretion in Cultured Pancreas

W. Fujimoto, S. Metz, R. Paul Robertson, 1981, Diabetes.

Phasic effects of glucose, phospholipase A2, and lysophospholipids on insulin secretion.

W. Fujimoto, S. Metz, 1987, Endocrinology.

Phasic Glucose-stimulated Insulin Secretion by Neonatal Rat Pancreatic Islet Cells: Enhancement by Sodium Salicylate

W. Fujimoto, S. Metz, 1984, Diabetes.

Roles of GTP and phospholipase C in the potentiation of Ca(2+)-induced insulin secretion by glucose in rat pancreatic islets.

M. Rabaglia, S. Metz, J. Vadakekalam, 1997, The Journal of endocrinology.

Interleukin-1β inhibits phospholipase C and insulin secretion at sites apart from KATPchannel.

M. Rabaglia, S. Metz, J. Vadakekalam, 1997, American journal of physiology. Endocrinology and metabolism.

Dual Functional Effects of Interleukin-1β on Purine Nucleotides and Insulin Secretion in Rat Islets and INS-1 Cells

M. Rabaglia, J. Corbett, S. Metz, 1996, Diabetes.

Small elevations of glucose concentration redirect and amplify the synthesis of guanosine 5'-triphosphate in rat islets.

M. Rabaglia, A. Kowluru, S. Metz, 1993, The Journal of clinical investigation.

Purine Nucleotide- and Sugar Phosphate-Induced Inhibition of the Carboxyl Methylation and Catalysis of Protein Phosphatase-2A in Insulin-Secreting Cells: Protection by Divalent Cations

A. Kowluru, S. Metz, 1998, Bioscience reports.

Regulation of guanine-nucleotide binding proteins in islet subcellular fractions by phospholipase-derived lipid mediators of insulin secretion.

A. Kowluru, S. Metz, 1994, Biochimica et biophysica acta.

Anti-inflammatory agents as inhibitors of prostaglandin synthesis in man.

S. Metz, 1981, The Medical clinics of North America.

A defect late in stimulus-secretion coupling impairs insulin secretion in Goto-Kakizaki diabetic rats.

M. Rabaglia, A. Kowluru, S. Metz, 1999, Diabetes.

A role for the lipoxygenase pathway of arachidonic acid metabolism in glucose- and glucagon-induced insulin secretion.

R. Robertson, W. Fujimoto, S. Metz, 1983, Life sciences.

Fuel Metabolism as a Determinant of Arachidonic Acid Release and Oxygenation

S. Metz, 1985 .

Selective inhibitors of GTP synthesis impede exocytotic insulin release from intact rat islets.

M. Rabaglia, S. Metz, T. Pintar, 1992, The Journal of biological chemistry.

GTP and Its Binding Proteins in the Regulation of Insulin Exocytosis

A. Kowluru, S. Metz, 1994 .

Exogenous Arachidonic Acid Promotes Insulin Release From Intact or Permeabilized Rat Islets by Dual Mechanisms: Putative Activation of Ca2+ Mobilization and Protein Kinase C

S. Metz, 1988, Diabetes.

Prostaglandins as mediators of paraneoplastic syndromes: review and up-date.

R. Robertson, S. Metz, J. McRae, 1981, Metabolism: clinical and experimental.

Feedback modulation of glucose-induced insulin secretion by arachidonic acid metabolites: possible molecular mechanisms and relevance to diabetes mellitus.

S. Metz, 1981, Prostaglandins and medicine.

Suppression of plasma catecholamines and flushing by clonidine in man.

J. Halter, D. Porte, R. Robertson, 1978, The Journal of clinical endocrinology and metabolism.

Applications and limitations of measurement of 15-keto,13,14-dihydro prostaglandin E2 in human blood by radioimmunoassay.

R. Robertson, S. Metz, M. Rice, 1979, Prostaglandins.

Is phospholipase A2 a "glucose sensor" responsible for the phasic pattern of insulin release?

S. Metz, 1984, Prostaglandins.

Ceramide‐activated protein phosphatase‐2A activity in insulin‐secreting cells

A. Kowluru, S. Metz, 1997, FEBS letters.

Activation of phospholipase D by glyceraldehyde in isolated islet cells follows protein kinase C activation.

S. Metz, M. Dunlop, 1992, Endocrinology.

Inhibition of the metabolism of phosphatidylethanol and phosphatidic acid, and stimulation of insulin release, by propranolol in intact pancreatic islets.

S. Metz, M. Dunlop, 1991, Biochemical pharmacology.

Sodium fluoride unmasks the accumulation of lysophosphatidylcholine in intact pancreatic islet cells.

S. Metz, M. Dunlop, 1990, Biochemical and biophysical research communications.

A phospholipase D-like mechanism in pancreatic islet cells: stimulation by calcium ionophore, phorbol ester and sodium fluoride.

S. Metz, M. Dunlop, 1989, Biochemical and biophysical research communications.

Membrane phospholipid turnover as an intermediary step in insulin secretion. Putative roles of phospholipases in cell signaling.

S. Metz, 1988, The American journal of medicine.

Is Protein Kinase C Required for Physiologic Insulin Release?

S. Metz, 1988, Diabetes.

Lipoxygenase inhibitors reduce insulin secretion without impairing calcium mobilization.

S. Metz, 1987, Endocrinology.

Metabolism of lysophospholipids in intact rat islets. The insulin secretagogue p-hydroxymercuribenzoic acid impairs lysophosphatidylcholine catabolism and permits its accumulation.

S. Metz, 1987, The Biochemical journal.

A re-interpretation of lipoxygenase-dependent insulin release: which metabolites of arachidonic acid, or none?

S. Metz, 1986, Life sciences.

Glucose increases the synthesis of lipoxygenase-mediated metabolites of arachidonic acid in intact rat islets.

S. Metz, 1985, Proceedings of the National Academy of Sciences of the United States of America.

Unmasking of arachidonate-induced insulin release by removal of extracellular calcium. Arachidonic acid mobilizes cellular calcium in rat islets of Langerhans.

B. Draznin, J. Leitner, S. Metz, 1987, Biochemical and biophysical research communications.

Lysophosphatidylinositol, but not lysophosphatidic acid, stimulates insulin release. A possible role for phospholipase A2 but not de novo synthesis of lysophospholipid in pancreatic islet function.

S. Metz, 1986, Biochemical and biophysical research communications.

[20] Subcellular distribution and posttranslational modifications of GTP-binding proteins in insulin-secreting cells

A. Kowluru, S. Metz, 1996 .

Epinephrine Impairs Insulin Release by a Mechanism Distal to Calcium Mobilization: Similarity to Lipoxygenase Inhibitors

S. Metz, 1988, Diabetes.

Dantrolene-induced inhibition of insulin release. A mechanism independent of effects on calcium fluxes.

S. Metz, 1988, Biochemical pharmacology.

Mobilization of cellular Ca2+ by lysophospholipids in rat islets of Langerhans.

S. Metz, 1988, Biochimica et biophysica acta.

Measurement of cytosolic free calcium concentration in relation to insulin release in normal rat pancreatic islets.

B. Draznin, J. Leitner, S. Metz, 1987, Diabetes research and clinical practice.

Lack of specificity of melittin as a probe for insulin release mediated by endogenous phospholipase A2 or lipoxygenase.

S. Metz, 1986, Biochemical pharmacology.

p-Hydroxymercuribenzoic acid inhibits arachidonic acid esterification into two distinct pools and stimulates insulin release in intact rat islets.

S. Metz, 1986, The Journal of pharmacology and experimental therapeutics.

Effects on Glucose-induced Insulin Secretion of Lipoxygenase-derived Metabolites of Arachidonic Acid

R. Murphy, W. Fujimoto, R. Murphy, 1984, Diabetes.

Evidence for lipoxygenase mediation of arachidonic acid-stimulated insulin secretion.

R. Robertson, W. Fujimoto, S. Metz, 1983, Advances in prostaglandin, thromboxane, and leukotriene research.

Lipoxygenation of arachidonic acid: a pivotal step in stimulus-secretion coupling in the pancreatic beta cell.

R. Robertson, W. Fujimoto, S. Metz, 1982, Endocrinology.

Plasma prostaglandin E in patients with cancer with and without hypercalcemia.

R. Robertson, S. Metz, K. Cummings, 1976, The Journal of clinical endocrinology and metabolism.

Neuroendocrine tumours that secrete biologically active peptides and amines.

S. Metz, R. Levine, 1977, Clinics in endocrinology and metabolism.

Sounding board. Prostaglandins, the glucoreceptor, and diabetes.

R. Robertson, S. Metz, 1979, The New England journal of medicine.

Non-specific stimulatory effects of mastoparan on pancreatic islet nucleoside diphosphokinase activity: dissociation from insulin secretion.

M. Rabaglia, S. Seavey, A. Kowluru, 1995, Biochemical pharmacology.

Characterization of nucleoside diphosphokinase activity in human and rodent pancreatic beta cells: evidence for its role in the formation of guanosine triphosphate, a permissive factor for nutrient-induced insulin secretion.

A. Kowluru, S. Metz, 1994, Biochemistry.

Evidence of a role for GTP in the potentiation of Ca(2+)-induced insulin secretion by glucose in intact rat islets.

M. Rabaglia, S. Metz, M. Meredith, 1995, The Journal of clinical investigation.

Ectopic secretion of chorionic gonadotropin by a lung carcinoma. Pituitary gonadotropin and subunit secretion and prolonged chemotherapeutic remission.

B. Weintraub, R. Robertson, S. Metz, 1978, The American journal of medicine.

Letter: Ectopic hormones from tumors.

S. Metz, 1975, Annals of internal medicine.

Prostaglandin E2 Metabolite Levels During Diabetic Ketoacidosis

R. P. Day, J. Halter, R. Robertson, 1985, Diabetes.

Cytosolic biosynthesis of GTP and ATP in normal rat pancreatic islets.

M. Rabaglia, S. Metz, M. Meredith, 1995, Biochimica et biophysica acta.

Genetic obesity unmasks nonlinear interactions between murine type 2 diabetes susceptibility loci.

B. Yandell, A. Attie, J. Stoehr, 2000, Diabetes.

Transdermal clonidine therapy in elderly mild hypertensives: effects on blood pressure, plasma norepinephrine and fasting plasma glucose.

S. Metz, C. Klein, N. Morton, 1985, Journal of hypertension. Supplement : official journal of the International Society of Hypertension.

Perspectives in diabetes. Is protein kinase C required for physiologic insulin release

S. Metz, 1988 .

Sodium salicylate augments the plasma adrenocorticotropin and cortisol responses to insulin hypoglycemia in man.

J. Halter, S. Metz, 1982, The Journal of clinical endocrinology and metabolism.

Putative roles for lysophospholipids as mediators and lipoxygenase-mediated metabolites of arachidonic acid as potentiators of stimulus-secretion coupling: dual mechanisms of p-hydroxymercuribenzoic acid-induced insulin release.

S. Metz, 1986, The Journal of pharmacology and experimental therapeutics.

Inosine monophosphate dehydrogenase: A molecular switch integrating pleiotropic GTP-dependent beta-cell functions.

A. Kowluru, S. Metz, Stewart A. Metz, 1999, Proceedings of the Association of American Physicians.

Production of phosphatidylethanol by phospholipase D phosphatidyl transferase in intact or dispersed pancreatic islets: evidence for the in situ metabolism of phosphatidylethanol.

S. Metz, M. Dunlop, 1990, Archives of biochemistry and biophysics.

Induction of Defective Insulin Secretion and Impaired Glucose Tolerance by Clonidine Selective Stimulation of Metabolic Alpha-adrenergic Pathways

J. Halter, S. Metz, R. Paul Robertson, 1978, Diabetes.

Evidence for differential roles of the Rho subfamily of GTP-binding proteins in glucose- and calcium-induced insulin secretion from pancreatic beta cells.

M. Rabaglia, A. Kowluru, K. Aktories, 1997, Biochemical pharmacology.

Subcellular localization and kinetic characterization of guanine nucleotide binding proteins in normal rat and human pancreatic islets and transformed beta cells.

M. Rabaglia, A. Kowluru, S. Metz, 1994, Biochimica et biophysica acta.

Glucose- and GTP-dependent stimulation of the carboxyl methylation of CDC42 in rodent and human pancreatic islets and pure beta cells. Evidence for an essential role of GTP-binding proteins in nutrient-induced insulin secretion.

M. Rabaglia, S. Seavey, A. Kowluru, 1996, The Journal of clinical investigation.

Characterization of prenylcysteine methyltransferase in insulin-secreting cells.

A. Kowluru, S. Metz, G. Li, 1996, The Biochemical journal.

Stimulation by prostaglandin E2 of a high-affinity GTPase in the secretory granules of normal rat and human pancreatic islets.

A. Kowluru, S. Metz, 1994, The Biochemical journal.

A novel regulatory mechanism for trimeric GTP-binding proteins in the membrane and secretory granule fractions of human and rodent beta cells.

S. Seavey, A. Kowluru, C. Rhodes, 1996, The Biochemical journal.

Rapid extraction of leukotrienes from biologic fluids and quantitation by high-performance liquid chromatography.

R. Murphy, R. Murphy, S. Metz, 1982, Journal of chromatography.