Ying Su

发表

Emodin enhances cisplatin-induced cytotoxicity via down-regulation of ERCC1 and inactivation of ERK1/2.

Yun-Wei Lin, J. Ko, Ying Su, 2010, Lung cancer.

Ultra-High-Throughput Screening of Natural Product Extracts to Identify Proapoptotic Inhibitors of Bcl-2 Family Proteins

J. Reed, M. Walters, K. Welsh, 2014, Journal of biomolecular screening.

Multicolor, one- and two-photon imaging of enzymatic activities in live cells with fluorescently Quenched Activity-Based Probes (qABPs).

Pengyu Yang, M. Uttamchandani, S. Yao, 2011, Journal of the American Chemical Society.

Elucidation of the specific function of the conserved threonine triad responsible for human L-asparaginase autocleavage and substrate hydrolysis.

A. Lavie, Ying Su, J. Nomme, 2014, Journal of molecular biology.

Structures of apo and product-bound human L-asparaginase: insights into the mechanism of autoproteolysis and substrate hydrolysis.

M. Konrad, A. Lavie, Ying Su, 2012, Biochemistry.

Title Development of new deoxycytidine kinase inhibitors and noninvasive in vivo evaluation using positron emission tomography

Jennifer M Murphy, M. Phelps, A. Lavie, 2013 .

Design, synthesis and evaluation of monovalent Smac mimetics that bind to the BIR2 domain of the anti-apoptotic protein XIAP.

John Calvin Reed, K. Welsh, K. Vuori, 2011, Bioorganic & medicinal chemistry letters.

Inhibition of Protein Kinase C-Driven Nuclear Factor-κB Activation: Synthesis, Structure−Activity Relationship, and Pharmacological Profiling of Pathway Specific Benzimidazole Probe Molecules

John Calvin Reed, J. Cashman, G. Roth, 2010, Journal of medicinal chemistry.

Insights into Regulated Ligand Binding Sites from the Structure of ZO-1 Src Homology 3-Guanylate Kinase Module*

A. Lavie, James M. Anderson, A. Fanning, 2010, The Journal of Biological Chemistry.

RXRα ligand Z-10 induces PML-RARα cleavage and APL cell apoptosis through disrupting PML-RARα/RXRα complex in a cAMP-independent manner

Ying Su, Hu Zhou, Xiao-Kun Zhang, 2017, Oncotarget.

Development of new deoxycytidine kinase inhibitors and noninvasive in vivo evaluation using positron emission tomography.

Jennifer M Murphy, M. Phelps, A. Lavie, 2013, Journal of medicinal chemistry.

The IGF-I/JAK2-STAT3/miR-21 signaling pathway may be associated with human renal cell carcinoma cell growth.

Jingjing Xu, Ying Su, J. Xu, 2017, Cancer biomarkers : section A of Disease markers.

Sulindac-derived RXRα modulators inhibit cancer cell growth by binding to a novel site.

R. Liddington, G. Cadwell, Ying Su, 2014, Chemistry & biology.

Celastrol-Induced Nur77 Interaction with TRAF2 Alleviates Inflammation by Promoting Mitochondrial Ubiquitination and Autophagy.

M. Diaz-Meco, J. Moscat, Zhaokai Wang, 2017, Molecular cell.

An adamantyl-substituted retinoid-derived molecule that inhibits cancer cell growth and angiogenesis by inducing apoptosis and binds to small heterodimer partner nuclear receptor: effects of modifying its carboxylate group on apoptosis, proliferation, and protein-tyrosine phosphatase activity.

T. Mustelin, M. Dawson, L. Jong, 2007, Journal of medicinal chemistry.

Discovery of 4-oxo-6-((pyrimidin-2-ylthio)methyl)-4H-pyran-3-yl 4-nitrobenzoate (ML221) as a functional antagonist of the apelin (APJ) receptor.

T. Chung, M. Hedrick, E. Sergienko, 2012, Bioorganic & medicinal chemistry letters.

Identification of a selective inhibitor of murine intestinal alkaline phosphatase (ML260) by concurrent ultra-high throughput screening against human and mouse isozymes.

T. Chung, Brock T Brown, M. Hedrick, 2014, Bioorganic & medicinal chemistry letters.

Virtual screening and experimental validation identify novel modulators of nuclear receptor RXRα from Drugbank database.

Xiaokun Zhang, Ying Su, Hu Zhou, 2017, Bioorganic & medicinal chemistry letters.

Opposite effects of arsenic trioxide on the Nrf2 pathway in oral squamous cell carcinoma in vitro and in vivo.

Min Zhang, Ying Su, Zheng Sun, 2012, Cancer letters.

Identification of Inhibitors of NOD1-Induced Nuclear Factor-κB Activation

John Calvin Reed, Brock T Brown, G. Roth, 2011, ACS medicinal chemistry letters.

P2X7R promotes angiogenesis and tumour‐associated macrophage recruitment by regulating the NF‐κB signalling pathway in colorectal cancer cells

S. Shi, Ying Su, J. Tong, 2020, Journal of cellular and molecular medicine.

Honokiol sensitizes breast cancer cells to TNF‐α induction of apoptosis by inhibiting Nur77 expression

Guanghui Wang, Xinlei Shi, Xindao Zhang, 2016, British journal of pharmacology.

Polarized cell migration induces cancer type-specific CD133/integrin/Src/Akt/GSK3β/β-catenin signaling required for maintenance of cancer stem cell properties

Yi-Wen Chang, Ying Su, Kuo-Chen Wei, 2015, Oncotarget.

Altered Structural and Mechanistic Properties of Mutant Dihydropteridine Reductases (*)

N. Xuong, Ying Su, K. Varughese, 1996, The Journal of Biological Chemistry.

Small-Molecule IAP Antagonists Sensitize Cancer Cells to TRAIL-Induced Apoptosis: Roles of XIAP and cIAPs

John Calvin Reed, K. Welsh, K. Vuori, 2013, Molecular Cancer Therapeutics.

High-Throughput Fluorescence Polarization Assay for Chemical Library Screening against Anti-Apoptotic Bcl-2 Family Member Bfl-1

John Calvin Reed, T. Chung, X. Chan, 2012, Journal of biomolecular screening.

SAR study of oxidative DIMs analogs targeting the Nur77-mediated apoptotic pathway of cancer cells.

Xindao Zhang, Xiaokun Zhang, Ying Su, 2022, Bioorganic chemistry.

The Janus-faced roles of Krüppel-like factor 4 in oral squamous cell carcinoma cells

Man Liu, Ying Su, Xinying Zhou, 2015, Oncotarget.

Structure-activity relationship and improved hydrolytic stability of pyrazole derivatives that are allosteric inhibitors of West Nile Virus NS2B-NS3 proteinase.

A. Strongin, N. Cosford, Ying Su, 2009, Bioorganic & medicinal chemistry letters.

Targeting truncated retinoid X receptor-α by CF31 induces TNF-α-dependent apoptosis.

X. Yao, Ying Su, Yi Dai, 2013, Cancer research.

Design and synthesis of selective inhibitors of placental alkaline phosphatase.

T. Chung, J. Cashman, J. Millán, 2010, Bioorganic & medicinal chemistry.

Design and synthesis of pyrazole derivatives as potent and selective inhibitors of tissue-nonspecific alkaline phosphatase (TNAP).

Brock T Brown, J. Millán, E. Sergienko, 2009, Bioorganic & medicinal chemistry letters.

Synthesis, biological evaluation, and molecular docking study of novel allyl-retrochalcones as a new class of protein tyrosine phosphatase 1B inhibitors.

Ying Su, Suqing Zheng, Weiwei Zhu, 2019, Bioorganic & medicinal chemistry.

AlCl3·6H2O-Catalyzed Friedel-Crafts Alkylation of Indoles by the para-Quinone Methide Moiety of Celastrol

Xiaokun Zhang, Ying Su, Hu Zhou, 2017, Molecules.

Crystal structures of bacterial FabH suggest a molecular basis for the substrate specificity of the enzyme

K. Gajiwala, K. Appelt, Ying Su, 2009, FEBS letters.

Direct reprogramming of stem cell properties in colon cancer cells by CD44

Yi-Wen Chang, Ying Su, Jia-Lin Lee, 2011, The EMBO journal.

A Novel l-Asparaginase with low l-Glutaminase Coactivity Is Highly Efficacious against Both T- and B-cell Acute Lymphoblastic Leukemias In Vivo.

A. Lavie, Michael J. Schlicht, P. Van Vlierberghe, 2018, Cancer research.

Design and Characterization of Erwinia Chrysanthemi l-Asparaginase Variants with Diminished l-Glutaminase Activity*

A. Lavie, Ying Su, H. Nguyen, 2016, The Journal of Biological Chemistry.

Target identification of biologically active small molecules via in situ methods.

Yuguo Zheng, S. Yao, Ying Su, 2013, Current opinion in chemical biology.

Discovery and validation of a series of aryl sulfonamides as selective inhibitors of tissue-nonspecific alkaline phosphatase (TNAP).

Brock T Brown, J. Millán, E. Sergienko, 2009, Journal of medicinal chemistry.

Identification and Characterization of Novel Tissue-Nonspecific Alkaline Phosphatase Inhibitors with Diverse Modes of Action

X. Chan, Brock T Brown, J. Millán, 2009, Journal of biomolecular screening.

Novel Peptide Isomer Strategy for Stable Inhibition of Catecholamine Release: Application to Hypertension

D. O'Connor, S. Mahata, M. Mahata, 2012, Hypertension.

Fluorescence-activated cell sorting and directed evolution of α-N-acetylgalactosaminidases using a quenched activity-based probe (qABP).

M. Uttamchandani, S. Yao, Ying Su, 2013, Chemical communications.

Structure-guided Engineering of Human Thymidine Kinase 2 as a Positron Emission Tomography Reporter Gene for Enhanced Phosphorylation of Non-natural Thymidine Analog Reporter Probe*

N. Satyamurthy, A. Lavie, J. Czernin, 2011, The Journal of Biological Chemistry.

Structural characterization of new deoxycytidine kinase inhibitors rationalizes the affinity-determining moieties of the molecules.

Jennifer M Murphy, A. Lavie, S. Olson, 2014, Acta crystallographica. Section D, Biological crystallography.

Role of Rad51 Down-Regulation and Extracellular Signal-Regulated Kinases 1 and 2 Inactivation in Emodin and Mitomycin C-Induced Synergistic Cytotoxicity in Human Non–Small-Cell Lung Cancer Cells

Yun-Wei Lin, Ying Su, Szu-Ting Lin, 2010, Molecular Pharmacology.

Role of Rad 51 Down-Regulation and Extracellular Signal-Regulated Kinases 1 and 2 Inactivation in Emodin and Mitomycin C-Induced Synergistic Cytotoxicity in Human Non – Small-Cell Lung Cancer Cells

Yun-Wei Lin, Ying Su, Szu-Ting Lin, 2010 .

SAR study of celastrol analogs targeting Nur77-mediated inflammatory pathway.

Ying Su, Siwei Yan, Ziwen Chen, 2019, European journal of medicinal chemistry.

Adamantyl-substituted retinoid-derived molecules that interact with the orphan nuclear receptor small heterodimer partner: effects of replacing the 1-adamantyl or hydroxyl group on inhibition of cancer cell growth, induction of cancer cell apoptosis, and inhibition of SRC homology 2 domain-containin

M. Dawson, L. Jong, J. Fontana, 2008, Journal of medicinal chemistry.

Design, synthesis and biological evaluation of acyl hydrazones-based derivatives as RXRα-targeted anti-mitotic agents.

Xiaokun Zhang, Ying Su, Xuan Zhang, 2022, Bioorganic chemistry.

Centrosomal Localization of RXRα Promotes PLK1 Activation and Mitotic Progression and Constitutes a Tumor Vulnerability.

Z. Yin, Zongxi Li, Ying Su, 2020, Developmental cell.

EN1 is a transcriptional dependency in triple-negative breast cancer associated with brain metastasis.

Andrew H. Beck, A. Beck, F. Beca, 2019, Cancer research.

Multiplex Imaging and Cellular Target Identification of Kinase Inhibitors via an Affinity-Based Proteome Profiling Approach

S. Sze, P. Hao, S. Yao, 2015, Scientific Reports.

Ripretinib (DCC-2618) Is a Switch Control Kinase Inhibitor of a Broad Spectrum of Oncogenic and Drug-Resistant KIT and PDGFRA Variants.

Stacie L. Bulfer, O. Rosen, M. Heinrich, 2019, Cancer cell.

Suppression of the dynamic interaction of estrogen receptor with chromatin is critical for therapeutic ligands to repress ER-mediated transcription activities

D. Tang, Ying Su, Jingyi Peng, 2020, Biotarget.

NSAID sulindac and its analog bind RXRalpha and inhibit RXRalpha-dependent AKT signaling.

Yu Cao, Hu Zhou, Weiwei Gao, 2010, Cancer cell.

Roles of MKK1/2-ERK1/2 and Phosphoinositide 3-Kinase–AKT Signaling Pathways in Erlotinib-Induced Rad51 Suppression and Cytotoxicity in Human Non–Small Cell Lung Cancer Cells

Yun-Wei Lin, S. Chuang, Chia-Che Chang, 2009, Molecular Cancer Research.

Roles of MKK 1 / 2-ERK 1 / 2 and Phosphoinositide 3-Kinase – AKT Signaling Pathways in Erlotinib-Induced Rad 51 Suppression and Cytotoxicity in Human Non – Small Cell Lung Cancer Cells

Yun-Wei Lin, S. Chuang, Chia-Che Chang, 2009 .

Free glycine accelerates the autoproteolytic activation of human asparaginase.

M. Konrad, A. Lavie, Ying Su, 2013, Chemistry & biology.

Diverse Targets of β-Catenin during the Epithelial-Mesenchymal Transition Define Cancer Stem Cells and Predict Disease Relapse.

M. Hsiao, Yi-Wen Chang, Ying Su, 2015, Cancer research.

MicroRNAs in Serum Exosomes as Potential Biomarkers in Clear-cell Renal Cell Carcinoma.

An Zhao, Wei Zhang, Ying Su, 2016, European urology focus.

Switch Control Inhibition of KIT and PDGFRA in Patients With Advanced Gastrointestinal Stromal Tumor: A Phase I Study of Ripretinib

Robin L. Jones, O. Rosen, M. Heinrich, 2020, Journal of clinical oncology : official journal of the American Society of Clinical Oncology.

Structural Insight into Substrate Selectivity of Erwinia chrysanthemil-Asparaginase

A. Lavie, Ying Su, H. Nguyen, 2016, Biochemistry.

3‐Cl‐AHPC inhibits pro‐HGF maturation by inducing matriptase/HAI‐1 complex formation

Ying Su, Hu Zhou, Zhiping Zeng, 2018, Journal of cellular and molecular medicine.

Knockdown of RhoC Inhibits Oral Squamous Cell Carcinoma Cell Invasion and Metastasis via Regulation of HMGA2

Ying Su, Yanlin Wu, Xinyan Zhang, 2021, Journal of oncology.

Retinoid X Receptor Alpha Nitro-ligand Z-10 and Its Optimized Derivative Z-36 Reduce β-Amyloid Plaques in Alzheimer's Disease Mouse Model.

Ying Su, Hu Zhou, Zhiping Zeng, 2018, Molecular pharmaceutics.

Opposite Effects of Garcinol on Tumor Energy Metabolism in Oral Squamous Cell Carcinoma Cells

Ying Su, Xinyan Zhang, Jie Fu, 2019, Nutrition and cancer.

Inhibition of Hematopoietic Protein Tyrosine Phosphatase Augments and Prolongs ERK1/2 and p38 Activation

T. Mustelin, T. Chung, Li Yang, 2012, ACS chemical biology.

Targeting truncated RXRα for cancer therapy.

Xiaokun Zhang, Ying Su, Hu Zhou, 2015, Acta biochimica et biophysica Sinica.

Optimization of novel oxidative DIMs as Nur77 modulators of the Nur77-Bcl-2 apoptotic pathway.

Xiaokun Zhang, Ying Su, Meichun Gao, 2020, European journal of medicinal chemistry.

Chemical biology strategy reveals pathway-selective inhibitor of NF-kappaB activation induced by protein kinase C.

T. Kipps, John Calvin Reed, J. Cashman, 2010, ACS chemical biology.

Restoration of the antiviral activity of 3'-azido-3'-deoxythymidine (AZT) against AZT-resistant human immunodeficiency virus by delivery of engineered thymidylate kinase to T cells.

C. Monnerjahn, M. Konrad, A. Lavie, 2008, The Journal of general virology.

Suppression of ERCC1 and Rad51 expression through ERK1/2 inactivation is essential in emodin-mediated cytotoxicity in human non-small cell lung cancer cells.

Yun-Wei Lin, J. Ko, Ying Su, 2010, Biochemical pharmacology.

Emodin enhances gefitinib-induced cytotoxicity via Rad51 downregulation and ERK1/2 inactivation.

Yun-Wei Lin, Wei‐Ting Lee, S. Chuang, 2009, Experimental cell research.

Design, synthesis and biological evaluation of tetrazole-containing RXRα ligands as anticancer agents.

Xiaokun Zhang, Ying Su, Qian Yang, 2019, European journal of medicinal chemistry.

Nitrostyrene Derivatives Act as RXRα Ligands to Inhibit TNFα Activation of NF-κB.

Ying Su, Hu Zhou, Jiacheng Lin, 2015, Cancer research.

Small Molecules Can Selectively Inhibit Ephrin Binding to the EphA4 and EphA2 Receptors*

G. Roth, N. Cosford, R. Noberini, 2008, Journal of Biological Chemistry.

Potent, selective, and orally available benzoisothiazolone phosphomannose isomerase inhibitors as probes for congenital disorder of glycosylation Ia.

H. Freeze, Brock T Brown, M. Hedrick, 2011, Journal of medicinal chemistry.

Mutation profile of drug resistant gastrointestinal stromal tumor (GIST) patients (pts) enrolled in the phase 1 study of DCC-2618.

O. Rosen, M. Heinrich, K. Ganjoo, 2018 .

Inhibition of the Hematopoietic Protein Tyrosine Phosphatase by Phenoxyacetic Acids.

T. Mustelin, T. Chung, X. Chan, 2011, ACS medicinal chemistry letters.

MMP-9 Knockdown Inhibits Oral Squamous Cell Carcinoma Lymph Node Metastasis in the Nude Mouse Tongue-Xenografted Model through the RhoC/Src Pathway

F. Gao, Ying Su, Yanlin Wu, 2021, Analytical cellular pathology.

Synthesis and SAR study of modulators inhibiting tRXRα-dependent AKT activation.

Weiwei Gao, Ying Su, Hu Zhou, 2013, European journal of medicinal chemistry.

Arg-Gly-Asp (RGD)-Modified E1A/E1B Double Mutant Adenovirus Enhances Antitumor Activity in Prostate Cancer Cells In Vitro and in Mice

Ying Su, Gu Zhang, Yipeng Xu, 2016, PloS one.

Celastrol binds to its target protein via specific noncovalent interactions and reversible covalent bonds.

Ying Su, Siwei Yan, Ziwen Chen, 2018, Chemical communications.

NSC-640358 acts as RXRα ligand to promote TNFα-mediated apoptosis of cancer cell

Guanghui Wang, Ying Su, A. Cheltsov, 2015, Protein & Cell.

Targeted Delivery of Deoxycytidine Kinase to Her2-Positive Cells Enhances the Efficacy of the Nucleoside Analog Fludarabine

A. Lavie, B. Kay, Ying Su, 2016, PloS one.

Characterization of folate receptor alpha (FRα) expression in archival tumor and biopsy samples from relapsed epithelial ovarian cancer patients: A phase I expansion study of the FRα-targeting antibody-drug conjugate mirvetuximab soravtansine

M. Birrer, A. Berkenblit, U. Matulonis, 2017, Gynecologic oncology.

Knockdown of Matrix Metallopeptidase 9 Inhibits Metastasis of Oral Squamous Cell Carcinoma Cells in a Zebrafish Xenograft Model

Ying Su, Linwei Li, Guozhu Ning, 2020, BioMed research international.

Oncogenic potential of truncated RXRα during colitis-associated colorectal tumorigenesis by promoting IL-6-STAT3 signaling

Hua‐Lang Wu, Ying Su, Hu Zhou, 2019, Nature Communications.

Choice of Capecitabine or S1 in Combination with Oxaliplatin based on Thymidine Phosphorylase and Dihydropyrimidine Dehydrogenase Expression Status in Patients with Advanced Gastric Cancer

Ying Su, Jiang Liu, Rui Chen, 2019, Journal of gastric cancer.

Discovery of atorvastatin as a tetramer stabilizer of nuclear receptor RXRα through structure-based virtual screening.

Xiaokun Zhang, Ying Su, Zhiping Zeng, 2019, Bioorganic chemistry.

Abstract C087: Phase 1 study of DCC-3014, an oral inhibitor of CSF1R, to assess the safety, tolerability, pharmacokinetics, and pharmacodynamics in patients with advanced solid tumors, including diffuse-type tenosynovial giant cell tumor

S. Leong, Ying Su, R. Ruiz-Soto, 2019 .

Oncogenic potential of truncated RXRα during colitis-associated colorectal tumorigenesis by promoting IL-6-STAT3 signaling

Hua‐Lang Wu, Ying Su, Hu Zhou, 2019, Nature Communications.

Online Supplement : Novel peptide isomer strategy for stable inhibition of catecholamine release : Application to hypertension

S. Mahata, M. Mahata, Ying Su, 2022 .

Direct reprogramming of stem cell properties in colon cancer cells by CD44

Yi-Wen Chang, Ying Su, Jia-Lin Lee, 2011, The EMBO journal.

HTS identifies novel and specific uncompetitive inhibitors of the two-component NS2B-NS3 proteinase of West Nile virus.

Michael C. Myers, Jeffrey W. Smith, A. Strongin, 2007, Assay and drug development technologies.

Multiplex Imaging and Cellular Target Identification of Kinase Inhibitors via an Affinity-Based Proteome Profiling Approach

S. Sze, P. Hao, Ying Su, 2015, Scientific Reports.