M. Belcourt

发表

Stable Suppression of the R2 Subunit of Ribonucleotide Reductase by R2-targeted Short Interference RNA Sensitizes p53(–/–) HCT-116 Colon Cancer Cells to DNA-damaging Agents and Ribonucleotide Reductase Inhibitors*

A. Sartorelli, J. G. Cory, Z. Lin, 2004, Journal of Biological Chemistry.

Tumor-targeted Salmonella expressing cytosine deaminase as an anticancer agent.

M. Belcourt, D. Bermudes, Stanley L. Lin, 2002, Human gene therapy.

Case Study: Identification of in vitro Metabolite/Decomposition Products of the Novel DNA Alkylating Agent Laromustine

A. Nassar, M. Belcourt, T. Lam, 2010 .

Excess ribonucleotide reductase R2 subunits coordinate the S phase checkpoint to facilitate DNA damage repair and recovery from replication stress.

A. Sartorelli, J. G. Cory, G. Shadel, 2007, Biochemical pharmacology.

Inhibition of DNA Cross-linking by Mitomycin C by Peroxidase-mediated Oxidation of Mitomycin C Hydroquinone*

D. Sherman, A. Sartorelli, M. Belcourt, 2001, The Journal of Biological Chemistry.

Exploring the mechanistic aspects of mitomycin antibiotic bioactivation in Chinese hamster ovary cells overexpressing NADPH:cytochrome C (P-450) reductase and DT-diaphorase.

S. Rockwell, A. Sartorelli, M. Belcourt, 1998, Advances in enzyme regulation.

Reversal of mitomycin C resistance by overexpression of bioreductive enzymes in Chinese hamster ovary cells.

D. Sherman, S. Rockwell, A. Sartorelli, 2001, Cancer research.

Mitomycin resistance in mammalian cells expressing the bacterial mitomycin C resistance protein MCRA.

D. Sherman, S. Rockwell, A. Sartorelli, 1999, Proceedings of the National Academy of Sciences of the United States of America.

Mitomycin C: a prototype bioreductive agent.

S. Rockwell, A. Sartorelli, M. Tomasz, 1994, Oncology research.

Differential toxicity of mitomycin C and porfiromycin to aerobic and hypoxic Chinese hamster ovary cells overexpressing human NADPH:cytochrome c (P-450) reductase.

S. Rockwell, A. Sartorelli, M. Belcourt, 1996, Proceedings of the National Academy of Sciences of the United States of America.

Tumour therapy using Salmonella

M. Sznol, X. Luo, M. Belcourt, 2000 .

Tumour-Selective Salmonella-Based Cancer Therapy

M. Belcourt, J. Pawelek, K. B. Low, 2001, Biotechnology & genetic engineering reviews.

Reduced Level of Ribonucleotide Reductase R2 Subunits Increases Dependence on Homologous Recombination Repair of Cisplatin-Induced DNA Damage

P. Glazer, A. Sartorelli, J. G. Cory, 2011 .

Enhancer and silencerlike sites within the transcribed portion of a Ty2 transposable element of Saccharomyces cerevisiae

P. Farabaugh, M. Belcourt, J. Clare, 1989, Molecular and cellular biology.

Structure of adduct X, the last unknown of the six major DNA adducts of mitomycin C formed in EMT6 mouse mammary tumor cells.

S. Rockwell, A. Sartorelli, M. Tomasz, 2000, Chemical research in toxicology.

Bioreductive metabolism of mitomycin C in EMT6 mouse mammary tumor cells: cytotoxic and non-cytotoxic pathways, leading to different types of DNA adducts. The effect of dicumarol.

S. Rockwell, A. Sartorelli, M. Tomasz, 2001, Biochemical pharmacology.

Preferential kill of hypoxic EMT6 mammary tumor cells by the bioreductive alkylating agent porfiromycin.

S. Keyes, S. Rockwell, A. Sartorelli, 1995, Advances in enzyme regulation.

Formation of a major DNA adduct of the mitomycin metabolite 2,7-diaminomitosene in EMT6 mouse mammary tumor cells treated with mitomycin C.

S. Rockwell, A. Sartorelli, M. Tomasz, 1998, Oncology research.

Nuclear Overexpression of NAD(P)H:Quinone Oxidoreductase 1 in Chinese Hamster Ovary Cells Increases the Cytotoxicity of Mitomycin C under Aerobic and Hypoxic Conditions*

S. Rockwell, A. Sartorelli, M. Tomasz, 2004, Journal of Biological Chemistry.

Reduced Level of Ribonucleotide Reductase R2 Subunits Increases Dependence on Homologous Recombination Repair of Cisplatin-Induced DNA Damage

P. Glazer, A. Sartorelli, J. G. Cory, 2011, Molecular Pharmacology.

Ribosomal frameshifting in the yeast retrotransposon Ty: tRNAs induce slippage on a 7 nucleotide minimal site

Philip J. Farabaugh, P. Farabaugh, M. Belcourt, 1990, Cell.

Efficient translational frameshifting occurs within a conserved sequence of the overlap between the two genes of a yeast Ty1 transposon.

P. Farabaugh, M. Belcourt, J. Clare, 1988, Proceedings of the National Academy of Sciences of the United States of America.

Case Study: The Unanticipated Loss of N2 from Novel DNA Alkylating Agent Laromustine by Collision‐Induced Dissociation: Novel Rearrangements

A. Nassar, M. Belcourt, T. Lam, 2010 .

Bioactivation of mitomycin antibiotics by aerobic and hypoxic Chinese hamster ovary cells overexpressing DT-diaphorase.

S. Rockwell, A. Sartorelli, M. Belcourt, 1996, Biochemical pharmacology.

Nuclear Localization of NADPH:Cytochrome c (P450) Reductase Enhances the Cytotoxicity of Mitomycin C to Chinese Hamster Ovary Cells

S. Rockwell, A. Sartorelli, M. Tomasz, 2005, Molecular Pharmacology.

Reduced Level of Ribonucleotide Reductase R2 Subunits Increases Dependence on Homologous Recombination Repair of Cisplatin-Induced DNA Damage

M. Belcourt, Yashang Lee, Peining Li, 2011, Molecular Pharmacology.

Reduced Level of Ribonucleotide Reductase R2 Subunits Increases Dependence on Homologous Recombination Repair of Cisplatin-Induced DNA Damage Molecular Fast

M. Belcourt, Alan C. Sartorelli, Z. P. Lin, 2011 .