Mohammad Hekmat-Nejad

发表

A requirement for replication in activation of the ATR-dependent DNA damage checkpoint.

K. Cimprich, P. Lupardus, M. Yee, 2002, Genes & development.

Inhibition of prenylated KRAS in a lipid environment

Charles A. Wartchow, W. Jahnke, E. Fang, 2017, PloS one.

Structure of a kinesin microtubule depolymerization machine

Robert Fletterick, R. Fletterick, R. Milligan, 2004, The EMBO journal.

Regulation of KinI kinesin ATPase activity by binding to the microtubule lattice

R. Milligan, C. Moores, Mohammad Hekmat-Nejad, 2003, The Journal of cell biology.

Xenopus ATR is a replication-dependent chromatin-binding protein required for the DNA replication checkpoint

K. Cimprich, M. Yee, J. Newport, 2000, Current Biology.

The kinase activities of interleukin-1 receptor associated kinase (IRAK)-1 and 4 are redundant in the control of inflammatory cytokine expression in human cells.

A. Manning, Brian R. Wong, P. Olson, 2009, Molecular immunology.

Scaffold hopping towards potent and selective JAK3 inhibitors: discovery of novel C-5 substituted pyrrolopyrazines.

Johannes C. Hermann, A. Kuglstatter, A. Lovey, 2014, Bioorganic & medicinal chemistry letters.

RAF inhibitors activate the MAPK pathway by relieving inhibitory autophosphorylation.

F. McCormick, M. Holderfield, D. Stuart, 2013, Cancer cell.

A Modeling-Derived Hypothesis on Chronicity in Respiratory Diseases: Desensitized Pathogen Recognition Secondary to Hyperactive IRAK/TRAF6 Signaling

Brian R. Wong, D. G. Morris, Mohammad Hekmat-Nejad, 2009, PloS one.

Design and Discovery of N-(3-(2-(2-Hydroxyethoxy)-6-morpholinopyridin-4-yl)-4-methylphenyl)-2-(trifluoromethyl)isonicotinamide, a Selective, Efficacious, and Well-Tolerated RAF Inhibitor Targeting RAS Mutant Cancers: The Path to the Clinic.

W. Sellers, M. P. Dillon, Y. Mishina, 2020, Journal of medicinal chemistry.

Steady-state kinetic characterization of kinase activity and requirements for Mg2+ of interleukin-1 receptor-associated kinase-4.

D. Swinney, Mohammad Hekmat-Nejad, Terrence Z. Cai, 2010, Biochemistry.

Expression, purification and characterization of inactive and active forms of ERK2 from insect expression system.

Mohammad Hekmat-Nejad, J. M. Cheng, G. Pardee, 2015, Protein expression and purification.

Cancer Cell Inhibitory Autophosphorylation of RAF Kinase in vitro and in cells

F. McCormick, M. Holderfield, D. Stuart, 2013 .

Design and Discovery of N-(2-Methyl-5'-morpholino-6'-((tetrahydro-2H-pyran-4-yl)oxy)-[3,3'-bipyridin]-5-yl)-3-(trifluoromethyl)benzamide (RAF709): A Potent, Selective, and Efficacious RAF Inhibitor Targeting RAS Mutant Cancers.

M. P. Dillon, Mallika Singh, E. Lees, 2017, Journal of medicinal chemistry.

Antitumor Properties of RAF709, a Highly Selective and Potent Inhibitor of RAF Kinase Dimers, in Tumors Driven by Mutant RAS or BRAF.

Joshua M. Korn, W. Sellers, F. Shen, 2018, Cancer research.

3-Amido pyrrolopyrazine JAK kinase inhibitors: development of a JAK3 vs JAK1 selective inhibitor and evaluation in cellular and in vivo models.

Alam Jahangir, Johannes C. Hermann, Seth Harris, 2013, Journal of medicinal chemistry.