Steven Bergink

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Rad23b26S Proteasome Shuttling Factor Reduced Cell Proliferation in Mice Lacking Erythropoietic Defect Associated with

Jeroen A. A. Demmers, S. Philipsen, W. Vermeulen, 2014 .

Erythropoietic Defect Associated with Reduced Cell Proliferation in Mice Lacking the 26S Proteasome Shuttling Factor Rad23b

Jeroen A. A. Demmers, S. Philipsen, W. Vermeulen, 2013, Molecular and Cellular Biology.

Versatile DNA damage detection by the global genome nucleotide excision repair protein XPC

A. Houtsmuller, J. Hoeijmakers, W. Vermeulen, 2008, Journal of Cell Science.

DNA damage triggers nucleotide excision repair-dependent monoubiquitylation of histone H2A.

J. Neefjes, A. Houtsmuller, J. Hoeijmakers, 2006, Genes & development.

The DNA repair-ubiquitin-associated HR23 proteins are constituents of neuronal inclusions in specific neurodegenerative disorders without hampering DNA repair

B. Oostra, J. Hoeijmakers, W. Vermeulen, 2006, Neurobiology of Disease.

Human USP3 Is a Chromatin Modifier Required for S Phase Progression and Genome Stability

Pier Paolo Di Fiore, Adriaan B. Houtsmuller, Wim Vermeulen, 2007, Current Biology.

FOXO1 controls protein synthesis and transcript abundance of mutant polyglutamine proteins, preventing protein aggregation

H. Kampinga, Wei-Guo Zhu, Jing Yang, 2021, Human molecular genetics.

HSP40/DNAJ Chaperones

H. Kampinga, Steven Bergink, E. Mattos, 2018 .

Role of Cdc48/p97 as a SUMO-targeted segregase curbing Rad51–Rad52 interaction

S. Jentsch, H. Leonhardt, L. Schermelleh, 2013, Nature Cell Biology.

Glioblastoma is associated with extensive accelerated brain ageing

B. Eggen, Steven Bergink, L. Barazzuol, 2022, bioRxiv.

DNAJs: more than substrate delivery to HSPA

H. Kampinga, Steven Bergink, Suzanne L. Dekker, 2015, Front. Mol. Biosci..

In vivo suppression of polyglutamine aggregation via co-condensation of the molecular chaperone DNAJB6

H. Kampinga, Steven Bergink, E. P. de Mattos, 2022, bioRxiv.

University of Groningen Recognition of DNA damage by XPC coincides with disruption of the XPC-RAD23 complex Bergink,

A. Houtsmuller, J. Hoeijmakers, W. Vermeulen, 2013 .

Recognition of DNA damage by XPC coincides with disruption of the XPC–RAD23 complex

A. Houtsmuller, J. Hoeijmakers, W. Vermeulen, 2012, The Journal of cell biology.

The FIGNL1-interacting protein C1orf112 is synthetic lethal with PICH and mediates RAD51 retention on chromatin

R. Fehrmann, M. V. van Vugt, Steven Bergink, 2022, bioRxiv.

Cooling of Cells and Organs Confers Extensive DNA Strand Breaks Through Oxidative Stress and ATP Depletion

F. Hoogstra-Berends, R. Henning, Steven Bergink, 2022, Cell transplantation.

The chaperone DNAJB6 surveils FG-nucleoporins and is required for interphase nuclear pore complex biogenesis

B. Giepmans, H. Kampinga, J. Kuipers, 2022, Nature Cell Biology.

Insulin-like growth factor 2 (IGF2) protects against Huntington’s disease through the extracellular disposal of protein aggregates

L. Ellerby, C. Hetz, K. Longo, 2020, bioRxiv.

Insulin-like growth factor 2 (IGF2) protects against HD through the extracellular disposal of protein aggregates

C. Hetz, K. Longo, F. Court, 2019 .

Genome instability and loss of protein homeostasis: converging paths to neurodegeneration?

Steven Bergink, L. Barazzuol, Anna Ainslie, 2020, Open Biology.

Myopathy associated BAG3 mutations lead to protein aggregation by stalling Hsp70 networks

H. Kampinga, S. Scherer, A. Rebelo, 2018, Nature Communications.

DNAJB chaperones suppress destabilised protein aggregation via a region unique from that used to inhibit amyloidogenesis.

H. Kampinga, Steven Bergink, H. Ecroyd, 2021, Journal of cell science.

DNAJB chaperones inhibit aggregation of destabilised proteins via a C-terminal region distinct from that used to prevent amyloid formation

H. Kampinga, Steven Bergink, H. Ecroyd, 2020, bioRxiv.

Locked in a vicious cycle: the connection between genomic instability and a loss of protein homeostasis

Steven Bergink, Wouter Huiting, 2020, Genome Instability & Disease.

A novel regulation mechanism of DNA repair by damage-induced and RAD23-dependent stabilization of xeroderma pigmentosum group C protein.

J. Hoeijmakers, W. Vermeulen, K. Sugasawa, 2003, Genes & development.

Heat shock proteins as potential targets for protective strategies in neurodegeneration

H. Kampinga, Steven Bergink, Harm H Kampinga, 2016, The Lancet Neurology.

DNAJB6, a Key Factor in Neuronal Sensitivity to Amyloidogenesis.

H. Kampinga, A. Fatima, D. Vilchez, 2020, Molecular cell.

Interplay of the Ubiquitin Proteasome System with Nucleotide Excision Repair

Steven Bergink, 2006 .

monoubiquitylation of histone H 2 A DNA damage triggers nucleotide excision repair-dependent data

Wim, J. Neefjes, A. Houtsmuller, 2006 .

Regulation of UV-induced DNA damage response by ubiquitylation.

Wim Vermeulen, W. Vermeulen, N. Jaspers, 2007, DNA repair.

Principles of ubiquitin and SUMO modifications in DNA repair

S. Jentsch, Steven Bergink, Stefan Jentsch, 2009, Nature.

Human USP3 is a chromatin modifier required for S-phase progression and genome stability

M. Lohuizen, W. Vermeulen, E. Citterio, 2008 .

Protein quality control in the nucleolus safeguards recovery of epigenetic regulators after heat shock

J. Martens, P. Angrand, H. Kampinga, 2019, eLife.

University of Groningen Protein quality control in the nucleolus safeguards recovery of epigenetic regulators after heat shock Azkanaz,

J. Martens, P. Angrand, H. Kampinga, 2019 .

Protein quality control in the nucleolus safeguards recovery of epigenetic regulators after heat

J. Martens, P. Angrand, H. Kampinga, 2019 .

Chaperones in Polyglutamine Aggregation: Beyond the Q-Stretch

H. Kampinga, Steven Bergink, E. Kuiper, 2017, Front. Neurosci..

Astrocytic expression of the chaperone DNAJB6 results in non-cell autonomous protection in Huntington’s disease

H. Kampinga, P. Dijkers, O. Sibon, 2019, Neurobiology of Disease.

The S/T-Rich Motif in the DNAJB6 Chaperone Delays Polyglutamine Aggregation and the Onset of Disease in a Mouse Model.

C. Dobson, H. Kampinga, C. Emanuelsson, 2016, Molecular cell.

A novel role of Hsp70 in the DNA damage response

R. Coppes, Steven Bergink, Mirjam Baanstra, 2018 .

A novel role of Hsp 70 in the DNA damage response

R. Coppes, Steven Bergink, Mirjam Baanstra, 2018 .

Protein Quality Control Pathways at the Crossroad of Synucleinopathies

H. Kampinga, Steven Bergink, R. Melki, 2020, Journal of Parkinson's disease.

Functional diversity between HSP70 paralogs caused by variable interactions with specific co-chaperones

Nadinath B. Nillegoda, H. Kampinga, M. Mayer, 2020, The Journal of Biological Chemistry.

Targeting DNA topoisomerases or checkpoint kinases results in an overload of chaperone systems, triggering aggregation of a metastable subproteome

H. Kampinga, J. LaCava, Steven Bergink, 2021, bioRxiv.

Preserving protein homeostasis prevents motor impairment in DNA Damage Response-compromised C. elegans

H. Kampinga, Alejandra Duque-Jaramillo, Steven Bergink, 2021, bioRxiv.

CHAPTER 4 DNAJB 6 delays Neurodegeneration in a Drosophila melanogaster Model for Huntington ’ s Disease via Non-Cell Autonomous Mechanisms

H. Kampinga, O. Sibon, Steven Bergink, 2019 .

On protein quality control, myofibrillar myopathies, and neurodegeneration

H. Kampinga, P. Dijkers, O. Sibon, 2017 .

Ectopic expression of DNAJB6 ameliorates Huntington’s disease phenotype in R6/2 mouse model

H. Kampinga, B. Sluis, Steven Bergink, 2014 .

The N terminus of the small heat shock protein HSPB7 drives its polyQ aggregation–suppressing activity

H. Kampinga, M. Haslbeck, Steven Bergink, 2019, The Journal of Biological Chemistry.

Myopathy associated BAG3 mutations lead to protein aggregation by stalling Hsp70 networks

S. Züchner, H. Kampinga, S. Scherer, 2018, Nature Communications.

On protein quality control, myofibrillar myopathies, and neurodegeneration

H. Kampinga, O. Sibon, Steven Bergink, 2017 .

Heat shock proteins as potential targets for protective strategies in neurodegeneration

H. Kampinga, Steven Bergink, 2016, The Lancet Neurology.

Hsp70 machinery vs protein aggregation

H. Kampinga, Steven Bergink, J. Brunsting, 2019 .

Regulation of protein homeostasis in acute and chronic stress

Steven Bergink, Paulina Troncoso-Escudero, P. Sardi, 2019 .

First Virtual International Congress on Cellular and Organismal Stress Responses, November 5–6, 2020

H. Kampinga, A. Edkins, A. Zhuravleva, 2021, Cell Stress and Chaperones.

The molecular chaperone DNAJB6 provides surveillance of FG-Nups and is required for interphase nuclear pore complex biogenesis

B. Giepmans, H. Kampinga, J. Kuipers, 2021, bioRxiv.

University of Groningen Protein quality control in the nucleolus safeguards recovery of epigenetic regulators after heat shock Azkanaz,

J. Martens, P. Angrand, H. Kampinga, 2019 .

Glioblastoma and its treatment are associated with extensive accelerated brain aging

Steven Bergink, D. Voshart, Anna Ainslie, 2024, Aging cell.

Astrocytic expression of the chaperone DNAJB6 results in non-cell autonomous protection in Huntington’s disease

H. Kampinga, P. Dijkers, O. Sibon, 2019, Neurobiology of Disease.

Versatile DNA damage detection by the global genome nucleotide excision repair protein XPC

A. Houtsmuller, J. Hoeijmakers, W. Vermeulen, 2008, Journal of Cell Science.

Functional diversity between HSP70 paralogs due to variable interactions with specific co-chaperones.

Nadinath B. Nillegoda, H. Kampinga, B. Bukau, 2020 .