E. Huston

发表

DISC1 and PDE4B Are Interacting Genetic Factors in Schizophrenia That Regulate cAMP Signaling

Jennifer E. Chubb, D. Blackwood, W. Muir, 2005, Science.

Mitotic activation of the DISC1-inducible cyclic AMP phosphodiesterase-4D9 (PDE4D9), through multi-site phosphorylation, influences cell cycle progression.

E. Hill, G. Baillie, A. Dunlop, 2014, Cellular signalling.

Molecular cloning and transient expression in COS7 cells of a novel human PDE4B cAMP-specific phosphodiesterase, HSPDE4B3.

R. Owens, M. Houslay, C. Catterall, 1997, The Biochemical journal.

Helix-1 of the cAMP-specific phosphodiesterase PDE4A1 regulates its phospholipase-D-dependent redistribution in response to release of Ca2+

M. Houslay, E. Huston, I. Gall, 2006, Journal of Cell Science.

Cyclic AMP Controls mTOR through Regulation of the Dynamic Interaction between Rheb and Phosphodiesterase 4D

M. Houslay, S. Jang, S. Ryu, 2010, Molecular and Cellular Biology.

MEK1 Binds Directly to βArrestin1, Influencing Both Its Phosphorylation by ERK and the Timing of Its Isoprenaline-stimulated Internalization*

G. Baillie, M. Houslay, D. Adams, 2009, Journal of Biological Chemistry.

In addition to the SH3 binding region, multiple regions within the N-terminal noncatalytic portion of the cAMP-specific phosphodiesterase, PDE4A5, contribute to its intracellular targeting.

M. Houslay, E. Huston, I. Gall, 2002, Cellular signalling.

Identification and Characterization of PDE4A11, a Novel, Widely Expressed Long Isoform Encoded by the Human PDE4A cAMP Phosphodiesterase Gene

Douglas J. MacMaster, Richard Graham Knowles, M. Houslay, 2005, Molecular Pharmacology.

Intracellular compartmentalization of PDE4 cyclic AMP-specific phosphodiesterases.

M. Houslay, S. Mackenzie, E. Huston, 1998, Methods.

Fluorescence Resonance Energy Transfer–Based Analysis of cAMP Dynamics in Live Neonatal Rat Cardiac Myocytes Reveals Distinct Functions of Compartmentalized Phosphodiesterases Cellular Biology

M. Zaccolo, T. Pozzan, M. Lohse, 2004 .

Coaggregation of DISC1 and mutant huntingtin dysregulates PDE4 in Huntington’s disease

A. Sawa, M. Houslay, N. Nukina, 2017 .

cAMP phosphodiesterase-4A1 (PDE4A1) has provided the paradigm for the intracellular targeting of phosphodiesterases, a process that underpins compartmentalized cAMP signalling.

G. Baillie, M. Houslay, E. Huston, 2006, Biochemical Society transactions.

Cyclic AMP Phosphodiesterase 4D (PDE4D) Tethers EPAC1 in a Vascular Endothelial Cadherin (VE-Cad)-based Signaling Complex and Controls cAMP-mediated Vascular Permeability*

G. Baillie, M. Houslay, E. Huston, 2010, The Journal of Biological Chemistry.

EPAC and PKA allow cAMP dual control over DNA-PK nuclear translocation

G. Baillie, M. Houslay, E. Krause, 2008, Proceedings of the National Academy of Sciences.

Attenuation of the Activity of the cAMP-specific Phosphodiesterase PDE4A5 by Interaction with the Immunophilin XAP2*

G. Baillie, M. Houslay, David G. McEwan, 2003, Journal of Biological Chemistry.

Altered expression of PDE1 and PDE4 cyclic nucleotide phosphodiesterase isoforms in 7-oxo-prostacyclin-preconditioned rat heart.

M. Houslay, E. Krause, G. Rena, 1997, Journal of molecular and cellular cardiology.

Pertussis toxin treatment increases glutamate release and dihydropyridine binding sites in cultured rat cerebellar granule neurons

E. Huston, M. Fazeli, A. Dolphin, 1993, Neuroscience.

A comparison of the effect of calcium channel ligands and GABAB agonists and antagonists on transmitter release and somatic calcium channel currents in cultured neurons

A. Dolphin, E. Huston, R. H. Scott, 1990, Neuroscience.

The involvement of multiple calcium channel sub-types in glutamate release from cerebellar granule cells and its modulation by GABAB receptor activation

E. Huston, A. Dolphin, J. Burley, 1995, Neuroscience.

In resting COS1 cells a dominant negative approach shows that specific, anchored PDE4 cAMP phosphodiesterase isoforms gate the activation, by basal cyclic AMP production, of AKAP-tethered protein kinase A type II located in the centrosomal region.

M. Houslay, K. Taskén, E. Huston, 2005, Cellular signalling.

PDE4 associates with different scaffolding proteins: modulating interactions as treatment for certain diseases.

M. Houslay, E. Huston, X. Li, 2008, Handbook of experimental pharmacology.

Expression, intracellular distribution and basis for lack of catalytic activity of the PDE4A7 isoform encoded by the human PDE4A cAMP-specific phosphodiesterase gene.

G. Baillie, M. Houslay, D. Adams, 2004, The Biochemical journal.

The Unique Amino-terminal Region of the PDE4D5 cAMP Phosphodiesterase Isoform Confers Preferential Interaction with β-Arrestins*

G. Baillie, M. Houslay, E. Huston, 2003, Journal of Biological Chemistry.

Occupancy of the catalytic site of the PDE4A4 cyclic AMP phosphodiesterase by rolipram triggers the dynamic redistribution of this specific isoform in living cells through a cyclic AMP independent process.

G. Baillie, M. Houslay, R. Terry, 2003, Cellular signalling.

Molecular cloning, genomic positioning, promoter identification, and characterization of the novel cyclic amp-specific phosphodiesterase PDE4A10.

M. Houslay, G. Rena, E. Huston, 2001, Molecular pharmacology.

Elucidation of a structural basis for the inhibitor-driven, p62 (SQSTM1)-dependent intracellular redistribution of cAMP phosphodiesterase-4A4 (PDE4A4).

G. Baillie, M. Houslay, F. Christian, 2011, Journal of medicinal chemistry.

TAPAS-1, a Novel Microdomain within the Unique N-terminal Region of the PDE4A1 cAMP-specific Phosphodiesterase That Allows Rapid, Ca2+-triggered Membrane Association with Selectivity for Interaction with Phosphatidic Acid*

Jim Warwicker, Michael J O Wakelam, J. Warwicker, 2002, The Journal of Biological Chemistry.

Evolutionarily Conserved Role of Calcineurin in Phosphodegron-Dependent Degradation of Phosphodiesterase 4D

Mark R. Duranski, Xiaoyong Yang, M. Lisanti, 2010, Molecular and Cellular Biology.

Phosphodiesterase-4 influences the PKA phosphorylation status and membrane translocation of G-protein receptor kinase 2 (GRK2) in HEK-293beta2 cells and cardiac myocytes.

G. Baillie, M. Houslay, Xiang Li, 2006, The Biochemical journal.

Cycloheximide abolishes pertussis toxin-induced increase in glutamate release from cerebellar granule neurones

A. Dolphin, E. Huston, G. Cullen, 1994, Neuroscience Letters.

Fluorescence Resonance Energy Transfer–Based Analysis of cAMP Dynamics in Live Neonatal Rat Cardiac Myocytes Reveals Distinct Functions of Compartmentalized Phosphodiesterases

Martin J. Lohse, Tullio Pozzan, Marco Mongillo, 2004, Circulation research.

Phosphodiesterase-8A binds to and regulates Raf-1 kinase

W. Kolch, J. Beavo, G. Baillie, 2013, Proceedings of the National Academy of Sciences.

G Protein Modulation of Calcium Entry and Transmitter Release a

M. Adams, A. Dolphin, E. Huston, 1991, Annals of the New York Academy of Sciences.

The Human Cyclic AMP-specific Phosphodiesterase PDE-46 (HSPDE4A4B) Expressed in Transfected COS7 Cells Occurs as Both Particulate and Cytosolic Species That Exhibit Distinct Kinetics of Inhibition by the Antidepressant Rolipram*

M. Houslay, E. Huston, G. Bolger, 1996, The Journal of Biological Chemistry.

Intracellular targeting, interaction with Src homology 3 (SH3) domains and rolipram-detected conformational switches in cAMP-specific PDE4A phosphodiesterase.

M. Houslay, G. Rena, S. Mackenzie, 1997, Biochemical Society transactions.

Association with the SRC Family Tyrosyl Kinase LYN Triggers a Conformational Change in the Catalytic Region of Human cAMP-specific Phosphodiesterase HSPDE4A4B

M. Houslay, E. Huston, S. Yarwood, 1999, The Journal of Biological Chemistry.

Elucidation of a structural basis for the inhibitor-driven, p62 (SQSTM1)-dependent intracellular redistribution of cAMP phosphodiesterase-4A4 (PDE4A4).

G. Baillie, M. Houslay, F. Christian, 2011, Journal of medicinal chemistry.

Cyclic AMP Controls mTOR through Regulation of the Dynamic Interaction between Rheb and Phosphodiesterase 4D

M. Houslay, S. Jang, M. N. Lee, 2010, Molecular and Cellular Biology.

Molecular cloning and transient expression in COS 7 cells of a novel human PDE 4 B cAMP-specific phosphodiesterase , HSPDE 4 B 3

R. Owens, M. Houslay, C. Catterall, 1997 .

The cAMP-specific phosphodiesterase PDE4A5 is cleaved downstream of its SH3 interaction domain by caspase-3. Consequences for altered intracellular distribution.

P. Vandenabeele, M. Houslay, N. Pyne, 2000, The Journal of biological chemistry.

Aggregation of scaffolding protein DISC1 dysregulates phosphodiesterase 4 in Huntington’s disease

N. Nukina, E. Huston, Yusuke Komi, 2017, Journal of the Neurological Sciences.

Research Portal

N. Nukina, E. Huston, Yusuke Komi, 2017 .

Coaggregation of DISC1 and mutant huntingtin dysregulates PDE4 in Huntington’s disease by

N. Nukina, E. Huston, Yusuke Komi, 2015 .

Coaggregation of DISC1 and mutant huntingtin dysregulates PDE4 in Huntington’s disease by

N. Nukina, E. Huston, Yusuke Komi, 2015 .