M. Llansola

V. Felipo, M. Malaguarnera, M. Llansola, 2017, Food and chemical toxicology : an international journal published for the British Industrial Biological Research Association.

GR3027 antagonizes GABAA receptor-potentiating neurosteroids and restores spatial learning and motor coordination in rats with chronic hyperammonemia and hepatic encephalopathy

V. Felipo, C. Montoliu, M. Llansola, 2015, American journal of physiology. Gastrointestinal and liver physiology.

GABAA receptor-potentiating neurosteroids and restores spatial learning and motor coordination in rats with chronic hyperammonemia and hepatic encephalopathy

C. Montoliu, M. Llansola, M. Doverskog, 2015 .

Progressive reduction of sleep time and quality in rats with hepatic encephalopathy caused by portacaval shunts

V. Felipo, J. L. Cantero, M. Errami, 2012, Neuroscience.

Chronic liver failure in rats impairs glutamatergic synaptic transmission and long‐term potentiation in hippocampus and learning ability

V. Felipo, S. Erceg, M. Llansola, 2007, The European journal of neuroscience.

Golexanolone, a GABAA receptor modulating steroid antagonist, restores motor coordination and cognitive function in hyperammonemic rats by dual effects on peripheral inflammation and neuroinflammation

V. Felipo, T. Blackburn, M. Llansola, 2022, CNS neuroscience & therapeutics.

A Multiomic Study To Unravel The Effects Of Developmental Exposure To Endosulfan In Rats: Molecular Explanation For Sex-Dependent Effects.

A. Conesa, V. Felipo, Sonia Tarazona, 2019, ACS chemical neuroscience.

Bicuculline Reduces Neuroinflammation in Hippocampus and Improves Spatial Learning and Anxiety in Hyperammonemic Rats. Role of Glutamate Receptors

V. Felipo, M. Malaguarnera, M. Llansola, 2019, Front. Pharmacol..

Increasing extracellular cGMP in cerebellum in vivo reduces neuroinflammation, GABAergic tone and motor in-coordination in hyperammonemic rats

V. Felipo, M. Malaguarnera, M. Llansola, 2017, Brain, Behavior, and Immunity.

Chronic hyperammonemia alters in opposite ways membrane expression of GluA1 and GluA2 AMPA receptor subunits in cerebellum. Molecular mechanisms involved.

V. Felipo, M. Llansola, A. Cabrera-Pastor, 2018, Biochimica et biophysica acta. Molecular basis of disease.

Inhibition of γ-Secretase Leads to an Increase in Presenilin-1

K. Blennow, V. Felipo, M. Llansola, 2017, Molecular Neurobiology.

Sildenafil reduces neuroinflammation in cerebellum, restores GABAergic tone, and improves motor in‐coordination in rats with hepatic encephalopathy

V. Felipo, C. Montoliu, M. Llansola, 2017, CNS neuroscience & therapeutics.

Extracellular Protein Kinase A Modulates Intracellular Calcium/Calmodulin-Dependent Protein Kinase II, Nitric Oxide Synthase, and the Glutamate-Nitric Oxide-cGMP Pathway in Cerebellum. Differential Effects in Hyperammonemia.

V. Felipo, M. Llansola, A. Cabrera-Pastor, 2016, ACS chemical neuroscience.

Extracellular cGMP Modulates Learning Biphasically by Modulating Glycine Receptors, CaMKII and Glutamate-Nitric Oxide-cGMP Pathway

V. Felipo, M. Malaguarnera, M. Llansola, 2016, Scientific Reports.

Infliximab reduces peripheral inflammation, neuroinflammation, and extracellular GABA in the cerebellum and improves learning and motor coordination in rats with hepatic encephalopathy

V. Felipo, J. Forteza, M. Llansola, 2016, Journal of Neuroinflammation.

Interplay between glutamatergic and GABAergic neurotransmission alterations in cognitive and motor impairment in minimal hepatic encephalopathy

V. Felipo, C. Montoliu, M. Malaguarnera, 2015, Neurochemistry International.

Translational research in hepatic encephalopathy: New diagnostic possibilities and new therapeutic approaches

V. Felipo, C. Montoliu, M. Malaguarnera, 2014 .

Mechanisms of cognitive alterations in hyperammonemia and hepatic encephalopathy: Therapeutical implications

V. Felipo, C. Montoliu, M. Llansola, 2009, Neurochemistry International.

Increasing the function of the glutamate‐nitric oxide‐cyclic guanosine monophosphate pathway increases the ability to learn a Y‐maze task

V. Felipo, C. Montoliu, S. Erceg, 2009, Journal of neuroscience research.

Glutamatergic and gabaergic neurotransmission and neuronal circuits in hepatic encephalopathy

V. Felipo, C. Montoliu, M. Llansola, 2009, Metabolic Brain Disease.

Chronic hyperammonemia impairs the glutamate–nitric oxide–cyclic GMP pathway in cerebellar neurons in culture and in the rat in vivo

V. Felipo, C. Hermenegildo, M. Miñana, 1998, The European journal of neuroscience.

Aluminium impairs the glutamate-nitric oxide-cGMP pathway in cultured neurons and in rat brain in vivo: molecular mechanisms and implications for neuropathology.

J. Canales, V. Felipo, C. Montoliu, 2001, Journal of inorganic biochemistry.

Prenatal Exposure to Aluminum Reduces Expression of Neuronal Nitric Oxide Synthase and of Soluble Guanylate Cyclase and Impairs Glutamatergic Neurotransmission in Rat Cerebellum

L Manzo, V. Felipo, M. Miñana, 1999, Journal of neurochemistry.

Sequential activation of soluble guanylate cyclase, protein kinase G and cGMP-degrading phosphodiesterase is necessary for proper induction of long-term potentiation in CA1 of hippocampus Alterations in hyperammonemia

Omar Cauli, Vicente Felipo, V. Felipo, 2004, Neurochemistry International.

Presence of diadenosine polyphosphates in microdialysis samples from rat cerebellum in vivo: effect of mild hyperammonemia on their receptors

V. Felipo, M. Llansola, J. Pintor, 2013, Purinergic Signalling.

Altered Modulation of Motor Activity by Group I Metabotropic Glutamate Receptors in the Nucleus Accumbens in Hyperammonemic Rats

V. Felipo, M. Errami, M. Llansola, 2005, Metabolic Brain Disease.

Hyperammonemia and liver failure alter signal transduction associated with glutamate receptors and modulation of guanylate cyclase by nitric oxide

V. Felipo, C. Montoliu, S. Erceg, 2003 .

Glutamate and muscarinic receptors in the molecular mechanisms of acute ammonia toxicity and of its prevention.

V. Felipo, C. Hermenegildo, M. Miñana, 1997, Advances in experimental medicine and biology.

Motor activity is modulated via different neuronal circuits in rats with chronic liver failure than in normal rats

V. Felipo, M. Llansola, O. Cauli, 2007, The European journal of neuroscience.

Neuroinflammation contributes to hypokinesia in rats with hepatic encephalopathy: Ibuprofen restores its motor activity

V. Felipo, M. Llansola, O. Cauli, 2009, Journal of neuroscience research.

Chronic hyperammonemia induces peripheral inflammation that leads to cognitive impairment in rats: reversal by anti-tnfa treatment.

V. Felipo, J. Forteza, S. Gil-Perotín, 2020, Journal of hepatology.

Reducing Peripheral Inflammation with Infliximab Reduces Neuroinflammation and Improves Cognition in Rats with Hepatic Encephalopathy

J. García-Verdugo, V. Felipo, J. Forteza, 2016, Front. Mol. Neurosci..

In vivo administration of extracellular cGMP normalizes TNF-α and membrane expression of AMPA receptors in hippocampus and spatial reference memory but not IL-1β, NMDA receptors in membrane and working memory in hyperammonemic rats

V. Felipo, M. Llansola, Tiziano Balzano, 2016, Brain, Behavior, and Immunity.

Hyperammonemia induces glial activation, neuroinflammation and alters neurotransmitter receptors in hippocampus, impairing spatial learning: reversal by sulforaphane

V. Felipo, M. Malaguarnera, M. Llansola, 2016, Journal of Neuroinflammation.

Sildenafil reduces neuroinflammation and restores spatial learning in rats with hepatic encephalopathy: underlying mechanisms

V. Felipo, C. Montoliu, M. Llansola, 2015, Journal of Neuroinflammation.

Potential Neuroprotective Role of Sugammadex: A Clinical Study on Cognitive Function Assessment in an Enhanced Recovery After Cardiac Surgery Approach and an Experimental Study

M. Llansola, V. Muedra, A. Agustí, 2022, Frontiers in Cellular Neuroscience.

Endosulfan and Cypermethrin Pesticide Mixture Induces Synergistic or Antagonistic Effects on Developmental Exposed Rats Depending on the Analyzed Behavioral or Neurochemical End Points.

V. Felipo, M. Llansola, A. Agustí, 2017, ACS chemical neuroscience.

Modulation of NMDA receptors in the cerebellum. 1. Properties of the NMDA receptor that modulate its function

V. Felipo, M. Llansola, O. Cauli, 2008, The Cerebellum.

Glutamine synthetase activity and glutamine content in brain: modulation by NMDA receptors and nitric oxide

V. Felipo, E. Kosenko, C. Montoliu, 2003, Neurochemistry International.

Role of cyclic GMP in glutamate neurotoxicity in primary cultures of cerebellar neurons

V. Felipo, E. Kosenko, C. Montoliu, 1999, Neuropharmacology.

NMDA receptors in hyperammonemia and hepatic encephalopathy

V. Felipo, E. Kosenko, C. Montoliu, 2007, Metabolic Brain Disease.

Rats with minimal hepatic encephalopathy show reduced cGMP-dependent protein kinase activity in hypothalamus correlating with circadian rhythms alterations

V. Felipo, J. Gaztelu, M. Llansola, 2015, Chronobiology international.

Cyclic GMP pathways in hepatic encephalopathy. Neurological and therapeutic implications

V. Felipo, C. Montoliu, M. Llansola, 2010, Metabolic Brain Disease.

Ammonia prevents glutamate-induced but not low K+-induced apoptosis in cerebellar neurons in culture

V. Felipo, L. Boscá, S. Hortelano, 2003, Neuroscience.

Metabotropic glutamate receptor 5, but not 1, modulates NMDA receptor-mediated activation of neuronal nitric oxide synthase

V. Felipo, M. Llansola, 2010, Neurochemistry International.

Modulation of NMDA receptors in the cerebellum. II. Signaling pathways and physiological modulators regulating NMDA receptor function

V. Felipo, M. Llansola, O. Cauli, 2008, The Cerebellum.

Modulation of NMDA receptor function by cyclic AMP in cerebellar neurones in culture

V. Felipo, C. Montoliu, M. Llansola, 2004, Journal of neurochemistry.

Inhibitors of phospholipase C prevent glutamate neurotoxicity in primary cultures of cerebellar neurons.

V. Felipo, M. Llansola, P. Monfort, 2000, The Journal of pharmacology and experimental therapeutics.

Gender differences in spatial learning, synaptic activity, and long-term potentiation in the hippocampus in rats: molecular mechanisms.

V. Felipo, M. Llansola, P. Monfort, 2015, ACS chemical neuroscience.

Restoration of learning ability in hyperammonemic rats by increasing extracellular cGMP in brain

V. Felipo, C. Montoliu, S. Erceg, 2005, Brain Research.

Cerebellum proteomics addressing the cognitive deficit of rats perinatally exposed to the food-relevant polychlorinated biphenyl 138.

Patrick De Boever, Vicente Felipo, Laura Brunelli, 2011, Toxicological sciences : an official journal of the Society of Toxicology.

Polychlorinated Biphenyls PCB 153 and PCB 126 Impair the Glutamate–Nitric Oxide–cGMP Pathway in Cerebellar Neurons in Culture by Different Mechanisms

V. Felipo, C. Montoliu, M. Llansola, 2009, Neurotoxicity Research.

Insight into the neuroproteomics effects of the food-contaminant non-dioxin like polychlorinated biphenyls.

Vicente Felipo, Alessandro Mariani, Laura Brunelli, 2012, Journal of proteomics.

Sildenafil reduces neuroinflammation and restores spatial learning in rats with hepatic encephalopathy: underlying mechanisms

V. Felipo, C. Montoliu, M. Llansola, 2015, Journal of Neuroinflammation.

A multi-omic study for uncovering molecular mechanisms associated with hyperammonemia-induced cerebellar function impairment in rats

A. Conesa, V. Felipo, Sonia Tarazona, 2021, Cell Biology and Toxicology.

Impaired release of corticosterone from adrenals contributes to impairment of circadian rhythms of activity in hyperammonemic rats.

V. Felipo, M. Errami, M. Llansola, 2013, Archives of biochemistry and biophysics.

Differential effects of chronic hyperammonemia on modulation of the glutamate–nitric oxide–cGMP pathway by metabotropic glutamate receptor 5 and low and high affinity AMPA receptors in cerebellum in vivo

V. Felipo, M. Llansola, J. Boix, 2012, Neurochemistry International.

Chronic exposure to ammonia alters the modulation of phosphorylation of microtubule-associated protein 2 by metabotropic glutamate receptors 1 and 5 in cerebellar neurons in culture

V. Felipo, S. Erceg, M. Llansola, 2005, Neuroscience.

GAIT-GM: Galaxy tools for modeling metabolite changes as a function of gene expression

A. Conesa, V. Felipo, L. McIntyre, 2020, bioRxiv.

Hyperammonemia induces glial activation, neuroinflammation and alters neurotransmitter receptors in hippocampus, impairing spatial learning: reversal by sulforaphane

V. Felipo, M. Malaguarnera, M. Llansola, 2016, Journal of Neuroinflammation.

Polychlorinated biphenyls PCB 52, PCB 180, and PCB 138 impair the glutamate-nitric oxide-cGMP pathway in cerebellar neurons in culture by different mechanisms.

V. Felipo, C. Montoliu, M. Llansola, 2010, Chemical research in toxicology.

Sustained hyperammonemia induces TNF-a IN Purkinje neurons by activating the TNFR1-NF-κB pathway

V. Felipo, J. Forteza, C. Montoliu, 2020, Journal of Neuroinflammation.

Chronic hyperammonemia alters protein phosphorylation and glutamate receptor-associated signal transduction in brain

V. Felipo, C. Montoliu, M. Llansola, 2002, Neurochemistry International.

Hyperammonemia Enhances GABAergic Neurotransmission in Hippocampus: Underlying Mechanisms and Modulation by Extracellular cGMP

V. Felipo, R. García-García, M. Llansola, 2022, Molecular Neurobiology.

Presence of diadenosine polyphosphates in microdialysis samples from rat cerebellum in vivo: effect of mild hyperammonemia on their receptors

V. Felipo, M. Llansola, J. Pintor, 2013, Purinergic Signalling.

Infliximab reduces peripheral inflammation, neuroinflammation, and extracellular GABA in the cerebellum and improves learning and motor coordination in rats with hepatic encephalopathy

V. Felipo, J. Forteza, M. Llansola, 2016, Journal of Neuroinflammation.

Prenatal exposure to polybrominated diphenylether 99 enhances the function of the glutamate–nitric oxide–cGMP pathway in brain in vivo and in cultured neurons

V. Felipo, C. Montoliu, S. Erceg, 2007, The European journal of neuroscience.

Chronic hyperammonemia, glutamatergic neurotransmission and neurological alterations

V. Felipo, C. Montoliu, M. Llansola, 2013, Metabolic Brain Disease.

Prevention of Ammonia and Glutamate Neurotoxicity by Carnitine: Molecular Mechanisms

V. Felipo, S. Erceg, M. Llansola, 2002, Metabolic Brain Disease.

Modulation of NMDA receptors by AKT kinase

V. Felipo, M. Llansola, A. Sánchez-Pérez, 2006, Neurochemistry International.

Role of nitric oxide and cyclic GMP in glutamate-induced neuronal death

V. Felipo, C. Montoliu, M. Llansola, 2001, Neurotoxicity Research.

Exploratory investigation on nitro- and phospho-proteome cerebellum changes in hyperammonemia and hepatic encephalopathy rat models

V. Felipo, R. Pastorelli, M. Llansola, 2012, Metabolic Brain Disease.

Sildenafil Treatment Eliminates Pruritogenesis and Thermal Hyperalgesia in Rats with Portacaval Shunts

V. Felipo, M. Llansola, A. Agustí, 2017, Neurochemical Research.

V. Felipo, M. Llansola, Tiziano Balzano, 2016, Journal of Neuroinflammation.

Metabotropic glutamate receptor 5 modulates the nitric oxide-cGMP pathway in cerebellum in vivo through activation of AMPA receptors

V. Felipo, M. Llansola, J. Boix, 2011, Neurochemistry International.

A multi-omic study for uncovering molecular mechanisms associated with hyperammonemia-induced cerebellar function impairment in rats

A. Conesa, V. Felipo, Sonia Tarazona, 2021, Cell Biology and Toxicology.

Roles of the NMDA Receptor and EAAC1 Transporter in the Modulation of Extracellular Glutamate by Low and High Affinity AMPA Receptors in the Cerebellum in Vivo: Differential Alteration in Chronic Hyperammonemia.

V. Felipo, M. Llansola, A. Cabrera-Pastor, 2015, ACS chemical neuroscience.

Role of NMDA and AMPA glutamatergic receptors in the effects of social defeat on the rewarding properties of MDMA in mice

V. Felipo, M. Llansola, J. Miñarro, 2018, The European journal of neuroscience.

NMDA‐induced phosphorylation of the microtubule‐associated protein MAP‐2 is mediated by activation of nitric oxide synthase and MAP kinase

V. Felipo, M. Llansola, R. Sáez, 2001, The European journal of neuroscience.

Chronic Exposure to Ammonia Alters Pathways Modulating Phosphorylation of Microtubule‐Associated Protein 2 in Cerebellar Neurons in Culture

V. Felipo, M. Llansola, R. Sáez, 1999, Journal of neurochemistry.

Carnitine prevents NMDA receptor-mediated activation of MAP-kinase and phosphorylation of microtubule-associated protein 2 in cerebellar neurons in culture

V. Felipo, M. Llansola, 2002, Brain Research.

Carbachol-Induced Hydrolysis of Phospholipids in Hippocampal Slices May Be Mediated in Part By Subsequent Activation of Metabotropic Glutamate Receptors

V. Felipo, C. Hermenegildo, M. Miñana, 1998, Neurochemical Research.

Prevention of glutamate neurotoxicity in cultured neurons by 3,4-dihydro-6-hydroxy-7-methoxy-2,2-dimethyl-1(2H)-benzopyran (CR-6), a scavenger of nitric oxide.

V. Felipo, C. Montoliu, A. Messeguer, 1999, Biochemical pharmacology.

V. Felipo, M. Llansola, Tiziano Balzano, 2016, Brain, Behavior, and Immunity.

Increasing extracellular cGMP in cerebellum in vivo reduces neuroinflammation, GABAergic tone and motor in-coordination in hyperammonemic rats

V. Felipo, M. Malaguarnera, M. Llansola, 2017, Brain, Behavior, and Immunity.

Golexanolone improves fatigue, motor incoordination and gait and memory in rats with bile duct ligation.

M. Llansola, Tiziano Balzano, Gergana Mincheva, 2023, Liver international : official journal of the International Association for the Study of the Liver.

Chronic hyperammonemia, glutamatergic neurotransmission and neurological alterations

V. Felipo, C. Montoliu, M. Llansola, 2012, Metabolic Brain Disease.

p38 MAP kinase is a therapeutic target for hepatic encephalopathy in rats with portacaval shunts

V. Felipo, M. Llansola, O. Cauli, 2011, Gut.

Patients who died with steatohepatitis or liver cirrhosis show neuroinflammation and neuronal loss in hippocampus

V. Felipo, C. Montoliu, M. Llansola, 2023, European journal of neurology.

Extracellular Vesicles from Mesenchymal Stem Cells Reverse Neuroinflammation and Restore Motor Coordination in Hyperammonemic Rats.

M. Llansola, M. Martínez-García, Paula Izquierdo-Altarejos, 2024, Journal of neuroimmune pharmacology : the official journal of the Society on NeuroImmune Pharmacology.