Zeger Debyser

发表

Novel Virtual Screening Protocol Based on the Combined Use of Molecular Modeling and Electron-Ion Interaction Potential Techniques To Design HIV-1 Integrase Inhibitors

Cristina Tintori, Fabrizio Manetti, Nevena Veljkovic, 2007, J. Chem. Inf. Model..

Efficient 3D Database Screening for Novel HIV-1 IN Inhibitors

Myriam Witvrouw, Zeger Debyser, M. Letizia Barreca, 2004, J. Chem. Inf. Model..

Serotype-dependent transduction efficiencies of recombinant adeno-associated viral vectors in monkey neocortex

Zeger Debyser, Wim Vanduffel, Marie-Eve Laramée, 2015, Neurophotonics.

Viral vector technology for target validation and drug discovery

Jo Vercammen, Myriam Witvrouw, Zeger Debyser, 2006 .

Quantitative evaluation of MRI-based tracking of ferritin-labeled endogenous neural stem cell progeny in rodent brain

Zeger Debyser, Frederik Maes, Annemarie van der Linden, 2012, NeuroImage.

Design and characterization of novel integration inhibitors

Zeger Debyser, Virginie Suchaud, Fabrice Bailly, 2011 .

Transient expression of LEDGF-chimera results in retargeted and safer lentiviral vector integration

Zeger Debyser, Rik Gijsbers, Manuel Grez, 2013 .

State-of-the-art lentiviral vectors for research use: risk assessment and biosafety recommendations.

Zeger Debyser, Rik Gijsbers, Jaan Toelen, 2009, Current gene therapy.

An integrated multi-electrode-optrode array for in vitro optogenetics

Robert Puers, Georges Gielen, Zeger Debyser, 2016, Scientific Reports.

HIV-1 Integrase Inhibitors: Pharmacophore Modeling and Rational Drug Design

Myriam Witvrouw, Zeger Debyser, Angela Rao, 2005 .

Synthesis and biological evaluation of novel antiviral agents as protein–protein interaction inhibitors

Zeger Debyser, Alba Chimirri, Rosaria Gitto, 2014, Journal of enzyme inhibition and medicinal chemistry.

A refined pharmacophore model for HIV-1 integrase inhibitors: Optimization of potency in the 1H-benzylindole series.

Myriam Witvrouw, Zeger Debyser, Alba Chimirri, 2008, Bioorganic & medicinal chemistry letters.

Integrase Mutants Defective for Interaction with LEDGF/p75 Are Impaired in Chromosome Tethering and HIV-1 Replication*

Myriam Witvrouw, Zeger Debyser, Linos Vandekerckhove, 2005, Journal of Biological Chemistry.

Fragment-based discovery of 8-hydroxyquinoline inhibitors of the HIV-1 integrase-lens epithelium-derived growth factor/p75 (IN-LEDGF/p75) interaction.

Zeger Debyser, Nouri Neamati, Frauke Christ, 2013, Journal of medicinal chemistry.

Noninvasive and Quantitative Monitoring of Adult Neuronal Stem Cell Migration in Mouse Brain Using Bioluminescence Imaging

Zeger Debyser, Johan Nuyts, Luc Mortelmans, 2008, Stem cells.

Synthesis and biological evaluation of an 123I-labeled bicyclic nucleoside analogue (BCNA) as potential SPECT tracer for VZV-tk reporter gene imaging.

Zeger Debyser, Jan Balzarini, Luc Mortelmans, 2007, Bioorganic & Medicinal Chemistry Letters.

Highly potent and selective inhibition of human immunodeficiency virus type 1 (HIV-1) by the HIV-1-specific reverse transcriptase inhibitors

Zeger Debyser, Erik De Clercq, Masanori Baba, 1992 .

Diffusion of Myelin Oligodendrocyte Glycoprotein in Living OLN-93 Cells Investigated by Raster-Scanning Image Correlation Spectroscopy (RICS)

Zeger Debyser, Johan Hofkens, Marcel Ameloot, 2008, Journal of Fluorescence.

Non-invasive imaging of neuropathology in a rat model of alpha-synuclein overexpression.

Zeger Debyser, Johan Nuyts, Koen Van Laere, 2007, Neurobiology of aging.

Interaction of the HIV-1 Intasome with Transportin 3 Protein (TNPO3 or TRN-SR2)*

Zeger Debyser, Mark P Foster, Frauke Christ, 2012, The Journal of Biological Chemistry.

Characterization of lentiviral vector-mediated gene transfer in adult mouse brain.

Zeger Debyser, Bart Nuttin, Veerle Baekelandt, 2002, Human gene therapy.

Quantification of 3D T2*-weighted MR images allows evaluation of different viral vectors for stable MR reporter gene expression in the rodent brain

Zeger Debyser, Tom Dresselaers, Uwe Himmelreich, 2010 .

Comparative analysis of adeno-associated viral vector serotypes 1, 2, 5, 7, and 8 in mouse brain.

Zeger Debyser, Luc Mortelmans, Veerle Baekelandt, 2007, Human gene therapy.

Quinolone 3-carboxylic acid pharmacophore: design of second generation HIV-1 integrase inhibitors.

Myriam Witvrouw, Zeger Debyser, Laith Q Al-Mawsawi, 2008, Journal of medicinal chemistry.

DNA-induced Polymerization of HIV-1 Integrase Analyzed with Fluorescence Fluctuation Spectroscopy*

Jo Vercammen, Zeger Debyser, Yves Engelborghs, 2002, The Journal of Biological Chemistry.

FK506 binding protein 12 differentially accelerates fibril formation of wild type alpha‐synuclein and its clinical mutants A30P or A53T

Zeger Debyser, Veerle Baekelandt, Yves Engelborghs, 2008, Journal of neurochemistry.

4-[1-(4-Fluorobenzyl)-4-hydroxy-1H-indol-3-yl]-2-hydroxy-4-oxobut-2-enoic acid as a prototype to develop dual inhibitors of HIV-1 integration process.

Zeger Debyser, Alba Chimirri, Rosaria Gitto, 2011, Antiviral research.

Discovery of small molecule HIV-1 integrase dimerization inhibitors.

Cristina Tintori, Silvio Massa, Zeger Debyser, 2012, Bioorganic & medicinal chemistry letters.

Retroviral integration: Site matters

Zeger Debyser, Rik Gijsbers, Jonas Demeulemeester, 2015, BioEssays : news and reviews in molecular, cellular and developmental biology.

Towards a Safer, More Randomized Lentiviral Vector Integration Profile Exploring Artificial LEDGF Chimeras

Zeger Debyser, Rik Gijsbers, Jonas Demeulemeester, 2016, PloS one.

Lentiviral vectors mediate efficient and stable gene transfer in adult neural stem cells in vivo.

Zeger Debyser, Veerle Baekelandt, J. García-Verdugo, 2006, Human gene therapy.

LEDGF hybrids efficiently retarget lentiviral integration into heterochromatin.

Zeger Debyser, Rik Gijsbers, Frederic D Bushman, 2010, Molecular therapy : the journal of the American Society of Gene Therapy.

Pharmacophore-based design of HIV-1 integrase strand-transfer inhibitors.

Myriam Witvrouw, Zeger Debyser, Angela Rao, 2005, Journal of medicinal chemistry.

Allele specific repair of splicing mutations in cystic fibrosis through AsCas12a genome editing

Zeger Debyser, Marianne S Carlon, Anabela S Ramalho, 2019, Nature Communications.

Fetal surgery is a clinical reality.

Zeger Debyser, Joris Vermeesch, Gunnar Naulaers, 2010, Seminars in fetal & neonatal medicine.

The aggregation of alpha‐synuclein is stimulated by FK506 binding proteins as shown by fluorescence correlation spectroscopy

Zeger Debyser, Veerle Baekelandt, Yves Engelborghs, 2006, FASEB journal : official publication of the Federation of American Societies for Experimental Biology.

Small molecules targeting the interaction between HIV-1 integrase and LEDGF/p75 cofactor.

Zeger Debyser, Alba Chimirri, Rosaria Gitto, 2010, Bioorganic & medicinal chemistry.

The remarkable conformational plasticity of alpha-synuclein: blessing or curse?

Zeger Debyser, Veerle Baekelandt, V. Baekelandt, 2013, Trends in molecular medicine.

Transportin-SR2 Imports HIV into the Nucleus

Zeger Debyser, Rik Gijsbers, Richard Benarous, 2008, Current Biology.

Inhibitory profile of a LEDGF/p75 peptide against HIV‐1 integrase: Insight into integrase–DNA complex formation and catalysis

Zeger Debyser, Nouri Neamati, Frauke Christ, 2008, FEBS letters.

Synthesis, Molecular Modelling and Biological Studies of 3-hydroxy-pyrane-4-one and 3-hydroxy-pyridine-4-one Derivatives as HIV-1 Integrase Inhibitors.

Zeger Debyser, Afshin Fassihi, Simone Brogi, 2018, Medicinal chemistry (Shariqah (United Arab Emirates)).

Quantitative assessment of gene-based versus particle based MRI contrast agents for progenitor cell tracking in rodent brain

Zeger Debyser, Frederik Maes, Tom Dresselaers, 2010 .

Virus Evolution Reveals an Exclusive Role for LEDGF/p75 in Chromosomal Tethering of HIV

Myriam Witvrouw, Zeger Debyser, Linos Vandekerckhove, 2007, PLoS pathogens.

New Class of HIV Integrase Inhibitors that Block Viral Replication in Cell Culture

Myriam Witvrouw, Zeger Debyser, Erik De Clercq, 2002, Current Biology.

HIV-1 Integrase Forms Stable Tetramers and Associates with LEDGF/p75 Protein in Human Cells*

Zeger Debyser, Yves Engelborghs, Bart Devreese, 2003, The Journal of Biological Chemistry.

Morphologic and functional changes in the unilateral 6-hydroxydopamine lesion rat model for Parkinson’s disease discerned with μSPECT and quantitative MRI

Zeger Debyser, Jan Sijbers, Marleen Verhoye, 2010, Magnetic Resonance Materials in Physics, Biology and Medicine.