T. Hirota

发表

Large-scale genome-wide association study in a Japanese population identifies novel susceptibility loci across different diseases

M. Kanai, Y. Kamatani, Y. Okada, 2020, Nature Genetics.

Large scale genome-wide association study in a Japanese population identified 45 novel susceptibility loci for 22 diseases

M. Kanai, Y. Kamatani, Y. Okada, 2019, bioRxiv.

Association between IFNA genotype and the risk of sarcoidosis

J. Casanova, A. Matsuda, S. Ohno, 2004, Human Genetics.

Multi-ethnic genome-wide association study of 21,000 cases and 95,000 controls identifies new risk loci for atopic dermatitis

Manuel A. R. Ferreira, M. Jarvelin, C. Gieger, 2015, Nature Genetics.

Functional polymorphism in the suppressor of cytokine signaling 1 gene associated with adult asthma.

Yusuke Nakamura, M. Shimizu, T. Shirakawa, 2007, American journal of respiratory cell and molecular biology.

Transforming growth factor‐β2 polymorphisms are associated with childhood atopic asthma

M. Ebisawa, T. Fukuda, A. Nakao, 2007, Clinical and experimental allergy : journal of the British Society for Allergy and Clinical Immunology.

Association between ADAM33 polymorphisms and adult asthma in the Japanese population

T. Shirakawa, M. Tamari, T. Hirota, 2006, Clinical and experimental allergy : journal of the British Society for Allergy and Clinical Immunology.

Functional promoter polymorphism in the TBX21 gene associated with aspirin-induced asthma

Yusuke Nakamura, M. Shimizu, C. Adra, 2005, Human Genetics.

Association of serum interleukin‐33 level and the interleukin‐33 genetic variant with Japanese cedar pollinosis

S. Fujieda, K. Nakanishi, M. Tamari, 2008, Clinical and experimental allergy : journal of the British Society for Allergy and Clinical Immunology.

The GSTP1 Gene Is a Susceptibility Gene for Childhood Asthma and the GSTM1 Gene Is a Modifier of the GSTP1 Gene

A. Hata, T. Shirakawa, Y. Matsubara, 2007, International Archives of Allergy and Immunology.

Associations of functional NLRP3 polymorphisms with susceptibility to food-induced anaphylaxis and aspirin-induced asthma.

Yusuke Nakamura, Y. Kohno, M. Ebisawa, 2009, The Journal of allergy and clinical immunology.

Endothelin-1 Pathway Polymorphisms and Outcomes in Pulmonary Arterial Hypertension.

A. Torbicki, H. Tiwari, M. Kubo, 2015, American journal of respiratory and critical care medicine.

A functional polymorphism in IL-18 is associated with severity of bronchial asthma.

Yusuke Nakamura, N. Higashi, M. Taniguchi, 2009, American journal of respiratory and critical care medicine.

Genetic impact of CDHR3 on the adult onset of asthma and COPD

M. Tamari, T. Hirota, H. Masuko, 2020, Clinical and experimental allergy : journal of the British Society for Allergy and Clinical Immunology.

Thymic stromal lymphopoietin gene promoter polymorphisms are associated with susceptibility to bronchial asthma.

Yusuke Nakamura, T. Tsunoda, S. Weiss, 2011, American journal of respiratory cell and molecular biology.

Polymorphisms in ADAM33 are associated with allergic rhinitis due to Japanese cedar pollen

M. Shimizu, T. Shirakawa, X. Mao, 2004, Clinical and experimental allergy : journal of the British Society for Allergy and Clinical Immunology.

Promoter polymorphisms in the IRF3 gene confer protection against systemic lupus erythematosus

T. Shirakawa, M. Tamari, T. Hirota, 2008, Lupus.

How important is allergic sensitization as a cause of atopic asthma?

M. Tamari, T. Hirota, H. Masuko, 2017, Allergology international : official journal of the Japanese Society of Allergology.

Lower FEV1 in non-COPD, nonasthmatic subjects: association with smoking, annual decline in FEV1, total IgE levels, and TSLP genotypes

E. Noguchi, M. Tamari, T. Hirota, 2011, International journal of chronic obstructive pulmonary disease.

Association of the IL12RB1 promoter polymorphisms with increased risk of atopic dermatitis and other allergic phenotypes.

M. Shimizu, Z. Ikezawa, T. Shirakawa, 2005, Human molecular genetics.

A NOD2 gene polymorphism is associated with the prevalence and severity of chronic obstructive pulmonary disease in a Japanese population

H. Date, S. Muro, H. Sakai, 2012, Respirology.

ORAI1 Genetic Polymorphisms Associated with the Susceptibility of Atopic Dermatitis in Japanese and Taiwanese Populations

Yusuke Nakamura, S. Juo, S. Fujieda, 2012, PloS one.

A genetic variant near TSLP is associated with chronic rhinosinusitis with nasal polyps and aspirin-exacerbated respiratory disease in Japanese populations.

S. Fujieda, M. Taniguchi, S. Takeno, 2019, Allergology international : official journal of the Japanese Society of Allergology.

ORMDL3/GSDMB genotype as a risk factor for early-onset adult asthma is linked to total serum IgE levels but not to allergic sensitization.

S. Konno, E. Noguchi, M. Tamari, 2020, Allergology international : official journal of the Japanese Society of Allergology.

A distinct sensitization pattern associated with asthma and the thymic stromal lymphopoietin (TSLP) genotype.

M. Nishimura, S. Konno, E. Noguchi, 2013, Allergology international : official journal of the Japanese Society of Allergology.

Late-breaking abstract: Genome-wide association of GLCCI1 with asthma steroid treatment response

Yusuke Nakamura, A. Litonjua, W. Qiu, 2011 .

Association analyses of eQTLs of the TYRO3 gene and allergic diseases in Japanese populations.

E. Noguchi, M. Tamari, T. Hirota, 2019, Allergology international : official journal of the Japanese Society of Allergology.

Long-term sublingual immunotherapy for Japanese cedar pollinosis and the levels of IL-17A and complement components 3a and 5a.

S. Fujieda, M. Tamari, T. Hirota, 2015, Cytokine.

Identification of Nine Novel Loci Associated with White Blood Cell Subtypes in a Japanese Population

Yusuke Nakamura, Kazuhiko Yamamoto, Tatsuhiko Tsunoda, 2011, PLoS genetics.

Genetic polymorphisms in the IL22 gene are associated with psoriasis vulgaris in a Japanese population.

Yusuke Nakamura, H. Nakagawa, S. Takeuchi, 2013, Journal of dermatological science.

Prevalence of Allergic Rhinitis and Sensitization to Common Aeroallergens in a Japanese Population

Yusuke Nakamura, T. Tsunoda, S. Fujieda, 2009, International Archives of Allergy and Immunology.

Genomewide association between GLCCI1 and response to glucocorticoid therapy in asthma.

Yusuke Nakamura, A. Litonjua, W. Qiu, 2011, The New England journal of medicine.

Lung functions of Japanese patients with chronic rhinosinusitis who underwent endoscopic sinus surgery.

S. Fujieda, M. Tamari, T. Hirota, 2014, Allergology international : official journal of the Japanese Society of Allergology.

Synergistic suppression of Poly(I:C)-induced CCL3 by a corticosteroid and a long acting β2 agonist in nasal epithelial cells.

S. Fujieda, M. Tamari, T. Hirota, 2015, Allergology international : official journal of the Japanese Society of Allergology.

Association between genetic variation in the gene for death-associated protein-3 (DAP3) and adult asthma

Yusuke Nakamura, M. Shimizu, H. Sekiguchi, 2004, Journal of Human Genetics.

Genome-Wide Association Study Identifies HLA-DP as a Susceptibility Gene for Pediatric Asthma in Asian Populations

Yusuke Nakamura, T. Asada, Teruhiko Yoshida, 2011, PLoS genetics.

S2554X mutation in the filaggrin gene is associated with allergen sensitization in the Japanese population.

T. Arinami, S. Fujieda, E. Noguchi, 2010, The Journal of allergy and clinical immunology.

[Eosinophilic chronic rhinosinusitis].

M. Urashima, S. Fujieda, T. Yamasoba, 2015, Arerugi = [Allergy].

Variants of C-C Motif Chemokine 22 (CCL22) Are Associated with Susceptibility to Atopic Dermatitis: Case-Control Studies

Yusuke Nakamura, Takashi Sasaki, M. Kubo, 2011, PloS one.

Bioconversion of 1,5-anhydro-D-fructose to 1,5-anhydro-D-glucitol and 1,5-anhydro-D-mannitol using Saccharomyces cerevisiae

T. Hirota, K. Yoshinaga, Abe Junichi, 2012 .

Associations of TNFAIP3 variants with susceptibility to psoriasis vulgaris and psoriasis arthritis in a Japanese population.

H. Nakagawa, Y. Umezawa, M. Tamari, 2020, Journal of dermatological science.

An association study of 36 psoriasis susceptibility loci for psoriasis vulgaris and atopic dermatitis in a Japanese population.

H. Nakagawa, S. Fujieda, S. Takeuchi, 2014, Journal of dermatological science.

ORMDL3/GSDMB genotype is associated with distinct phenotypes of adult asthma.

S. Konno, E. Noguchi, M. Tamari, 2021, Allergology international : official journal of the Japanese Society of Allergology.

Xanthan gum-based fluid thickener decreases postprandial blood glucose associated with increase of Glp1 and Glp1r expression in ileum and alteration of gut microbiome

Naofumi Uesaka, T. Hirota, H. Tohara, 2022, Journal of Functional Foods.

Genome-wide association study identifies eight new susceptibility loci for atopic dermatitis in the Japanese population

Yusuke Nakamura, T. Tsunoda, Takashi Sasaki, 2012, Nature Genetics.

Haplotypes with Copy Number and Single Nucleotide Polymorphisms in CYP2A6 Locus Are Associated with Smoking Quantity in a Japanese Population

Y. Okada, Yusuke Nakamura, Toshihiro Tanaka, 2012, PloS one.

An association study of asthma and related phenotypes with polymorphisms in negative regulator molecules of the TLR signaling pathway

Yusuke Nakamura, M. Shimizu, F. Kishi, 2006, Journal of Human Genetics.

Effects of Low-Level Er:YAG Laser Irradiation on Proliferation and Calcification of Primary Osteoblast-Like Cells Isolated From Rat Calvaria

A. Aoki, H. Kadokura, T. Hirota, 2020, Frontiers in Cell and Developmental Biology.

Replication of genetic association studies in asthma and related phenotypes

Y. Okamoto, A. Hata, Y. Kohno, 2010, Journal of Human Genetics.

Association study of the C3 gene with adult and childhood asthma

Y. Okamoto, A. Hata, Y. Kohno, 2008, Journal of Human Genetics.

Large scale genotyping study for asthma in the Japanese population

T. Arinami, M. Ebisawa, E. Noguchi, 2009, BMC Research Notes.

Multi-ethnic genome-wide association study of 21,000 cases and 95,000 controls identifies new risk loci for atopic dermatitis

David M. Evans, M. Jarvelin, C. Gieger, 2015, Nature Genetics.

Genome-Wide Association Study for Levels of Total Serum IgE Identifies HLA-C in a Japanese Population

M. Nishimura, S. Fujieda, S. Konno, 2013, PloS one.

Genome‐wide association studies of atopic dermatitis

M. Tamari, T. Hirota, 2014, The Journal of dermatology.

Genome-Wide Association Studies of Allergic Diseases.

Shota Tanaka, M. Tamari, T. Hirota, 2013, Allergology international : official journal of the Japanese Society of Allergology.

Associations between decay‐accelerating factor polymorphisms and allergic respiratory diseases

T. Arinami, E. Noguchi, M. Tamari, 2009, Clinical and experimental allergy : journal of the British Society for Allergy and Clinical Immunology.

Approaches to Understanding the Genetic Basis of Complex Diseases: Overview—What Is the Rationale for the Genome-Wide Approach to Understand Complex Diseases, Its Application and Limitations

M. Tamari, T. Hirota, 2018 .

Genome-Wide Association Study for Atopic Dermatitis in the Japanese Population

M. Tamari, T. Hirota, 2018 .

Genetic factors of childhood asthma

M. Tamari, T. Hirota, 2013 .

High-density genotyping study identifies four new susceptibility loci for atopic dermatitis

Yusuke Nakamura, Sen Yang, Andre Franke, 2013, Nature Genetics.

Genome-wide association study identifies three new susceptibility loci for adult asthma in the Japanese population

Yusuke Nakamura, Tatsuhiko Tsunoda, Scott T. Weiss, 2011, Nature Genetics.

Functional analysis of the thymic stromal lymphopoietin variants in human bronchial epithelial cells.

Yusuke Nakamura, S. Ziegler, M. Ebisawa, 2009, American journal of respiratory cell and molecular biology.

Filaggrin null mutations are associated with atopic dermatitis and elevated levels of IgE in the Japanese population: a family and case–control study

T. Arinami, S. Fujieda, F. Otsuka, 2008, Journal of Human Genetics.

Lack of Association between the IL13 Variant Arg110Gln and Susceptibility to Cedar Pollinosis in a Japanese Population

M. Shimizu, T. Shirakawa, X. Mao, 2005, International Archives of Allergy and Immunology.

Genome-wide association study of recalcitrant atopic dermatitis in Korean children.

D. Nicolae, C. Ober, M. Kubo, 2015, The Journal of allergy and clinical immunology.

Heritability of pulmonary function estimated from genome-wide SNPs in healthy Japanese adults.

E. Noguchi, M. Tamari, T. Hirota, 2015, Respiratory investigation.

Genetic determinants of risk in autoimmune pulmonary alveolar proteinosis

Y. Okada, F. Matsuda, Y. Inoue, 2021, Nature Communications.

Large-scale genome-wide association study in a Japanese population identifies novel susceptibility loci across different diseases

M. Kanai, Y. Kamatani, Y. Okada, 2020, Nature Genetics.

IL4Rα and ADAM33 as genetic markers in asthma exacerbations and type‐2 inflammatory endotype

M. Mishima, K. Izuhara, A. Yokoyama, 2017, Clinical and experimental allergy : journal of the British Society for Allergy and Clinical Immunology.

Coding SNP in tenascin-C Fn-III-D domain associates with adult asthma.

Yusuke Nakamura, T. Tsunoda, M. Shimizu, 2005, Human molecular genetics.

Association of the RIP2 gene with childhood atopic asthma.

Yusuke Nakamura, M. Shimizu, M. Ebisawa, 2006, Allergology international : official journal of the Japanese Society of Allergology.

A cis-eQTL allele regulating reduced expression of CHI3L1 is associated with late-onset adult asthma in Japanese cohorts

M. Nishimura, S. Konno, E. Noguchi, 2019, BMC Medical Genetics.

An association between asthma and TNF-308G/A polymorphism: meta-analysis

T. Arinami, E. Noguchi, M. Tamari, 2006, Journal of Human Genetics.

A functional polymorphism in MMP-9 is associated with childhood atopic asthma.

Yusuke Nakamura, M. Shimizu, M. Ebisawa, 2006, Biochemical and biophysical research communications.

Variants at HLA-A, HLA-C, and HLA-DQB1 Confer Risk of Psoriasis Vulgaris in Japanese.

M. Kanai, Y. Okada, Toshihiro Tanaka, 2017, The Journal of investigative dermatology.

Laser irradiation decreases sclerostin expression in bone and osteogenic cells

A. Aoki, K. Mizutani, H. Kadokura, 2020, FASEB journal : official publication of the Federation of American Societies for Experimental Biology.

Increased periostin associates with greater airflow limitation in patients receiving inhaled corticosteroids.

Y. Nakano, M. Mishima, K. Izuhara, 2013, The Journal of allergy and clinical immunology.

Genetics (AAGC) (2015). Multi-ancestry genome-wide association study of 21,000 cases and 95,000 controls identifies new risk loci for atopic dermatitis.

Weidinger, M. Jarvelin, C. Gieger, 2015 .

Variants in the 17q21 asthma susceptibility locus are associated with allergic rhinitis in the Japanese population

K. Tomita, M. Tamari, T. Hirota, 2013, Allergy.

Staphylococcus aureus enterotoxin sensitization involvement and its association with the CysLTR1 variant in different asthma phenotypes.

T. Kawaguchi, F. Matsuda, Y. Nakano, 2017, Annals of allergy, asthma & immunology : official publication of the American College of Allergy, Asthma, & Immunology.

Endotoxemia by Porphyromonas gingivalis Injection Aggravates Non-alcoholic Fatty Liver Disease, Disrupts Glucose/Lipid Metabolism, and Alters Gut Microbiota in Mice

Y. Izumi, N. Miyasaka, Y. Takeuchi, 2018, Front. Microbiol..

GLCCI1 variant accelerates pulmonary function decline in patients with asthma receiving inhaled corticosteroids

Y. Nakano, M. Mishima, A. Yokoyama, 2014, Allergy.

Functional SNPs in the distal promoter of the ST2 gene are associated with atopic dermatitis.

S. Tominaga, M. Shimizu, Y. Okayama, 2005, Human molecular genetics.

Porphyromonas gingivalis impairs glucose uptake in skeletal muscle associated with altering gut microbiota

Hirokazu Takahashi, Y. Eguchi, T. Hirota, 2020, FASEB journal : official publication of the Federation of American Societies for Experimental Biology.

Functional analysis of a polymorphism in the promoter region of the IL‐12/23p40 gene

M. Tamari, K. Okumura, T. Hirota, 2009, Clinical and experimental allergy : journal of the British Society for Allergy and Clinical Immunology.

HLA-DQ and RBFOX1 as susceptibility genes for an outbreak of hydrolyzed wheat allergy.

R. Kishikawa, Y. Kamatani, Y. Okada, 2019, The Journal of allergy and clinical immunology.

A functional polymorphism (−603A → G) in the tissue factor gene promoter is associated with adult-onset asthma

M. Nishimura, S. Konno, M. Tamari, 2010, Journal of Human Genetics.

Functional haplotypes of IL-12B are associated with childhood atopic asthma.

Yusuke Nakamura, M. Shimizu, M. Ebisawa, 2005, The Journal of allergy and clinical immunology.

Association of the hCLCA1 gene with childhood and adult asthma

M. Shimizu, T. Shirakawa, X. Mao, 2004, Genes and Immunity.

Role of Lung Function Genes in the Development of Asthma

M. Nishimura, S. Konno, E. Noguchi, 2016, PloS one.

Genome-wide association studies of asthma.

M. Tamari, T. Hirota, K. Tomita, 2011, Allergology international : official journal of the Japanese Society of Allergology.

Genetic polymorphism regulating ORM1-like 3 (Saccharomyces cerevisiae) expression is associated with childhood atopic asthma in a Japanese population.

Yusuke Nakamura, M. Ebisawa, E. Noguchi, 2008, The Journal of allergy and clinical immunology.

An interaction between Nrf2 polymorphisms and smoking status affects annual decline in FEV1: a longitudinal retrospective cohort study

E. Noguchi, M. Tamari, T. Hirota, 2011, BMC Medical Genetics.

Porphyromonas gingivalis Administration Induces Gestational Obesity, Alters Gene Expression in the Liver and Brown Adipose Tissue in Pregnant Mice, and Causes Underweight in Fetuses

N. Miyasaka, S. Yoshida, A. Hirose, 2022, Frontiers in Cellular and Infection Microbiology.

Novel IL36RN gene mutation revealed by analysis of 8 Japanese patients with generalized pustular psoriasis.

H. Nakagawa, S. Fujieda, Y. Umezawa, 2014, Journal of dermatological science.

Association of interleukin 1 receptor-like 1 gene polymorphisms with eosinophilic phenotype in Japanese adults with asthma.

S. Wenzel, M. Mishima, A. Niimi, 2017, Respiratory investigation.

Genomewide association study identifies HAS2 as a novel susceptibility gene for adult asthma in a Japanese population

S. Konno, E. Noguchi, M. Tamari, 2014, Clinical and experimental allergy : journal of the British Society for Allergy and Clinical Immunology.

Filaggrin loss-of-function mutations are not a predisposing factor for atopic dermatitis in an Ishigaki Island under subtropical climate.

J. Hayashi, A. Shiohama, Takashi Sasaki, 2014, Journal of dermatological science.

Association study of childhood food allergy with genome-wide association studies-discovered loci of atopic dermatitis and eosinophilic esophagitis.

Teruaki Matsui, Komei Ito, Tsuguhisa Nakayama, 2017, The Journal of allergy and clinical immunology.

Endotoxemia by Porphyromonas gingivalis Alters Endocrine Functions in Brown Adipose Tissue

Hirokazu Takahashi, S. Yoshida, Kazuki Morita, 2021, Frontiers in Cellular and Infection Microbiology.

A rare variant in CYP 27 A 1 and its association with atopic dermatitis with high serum total IgE Short title : CYP 27 A 1 association with atopic dermatitis

J. Furuta, E. Noguchi, M. Tamari, 2016 .

[Clinical relevance of biomarkers in allergic rhinitis].

S. Fujieda, M. Tamari, T. Hirota, 2014, Arerugi = [Allergy].

A rare variant in CYP27A1 and its association with atopic dermatitis with high serum total IgE

J. Furuta, E. Noguchi, M. Tamari, 2016, Allergy.

Author’s response to reviews Title: A cis-eQTL allele regulating reduced expression of CHI3L1 is associated with late-onset adult asthma in Japanese cohorts Authors:

M. Nishimura, E. Noguchi, M. Tamari, 2019 .

Variants near the HLA complex group 22 gene (HCG22) confer increased susceptibility to late-onset asthma in Japanese populations.

H. Makita, M. Nishimura, S. Kudoh, 2016, The Journal of allergy and clinical immunology.

Host molecular defense mechanisms against Chlamydophila pneumoniae and genetic studies of immune-response-related genes in asthma.

Yusuke Nakamura, M. Tamari, T. Hirota, 2009, Recent patents on inflammation & allergy drug discovery.

Genomic screening for Chlamydophila pneumoniae-specific antigens using serum samples from patients with primary infection.

I. Yanatori, F. Kishi, K. Miura, 2012, FEMS microbiology letters.

Genome-wide association studies

T. Hirota, K. Tomita, Asthma Tamari, 2021, Nature Reviews Methods Primers.

Comprehensive and Sequential Gene Expression Analysis of Bone Healing Process Following Er:YAG Laser Ablation.

A. Aoki, K. Mizutani, T. Hirota, 2020, Photobiomodulation, photomedicine, and laser surgery.

Genetic association of the functional CDHR3 genotype with early-onset adult asthma in Japanese populations.

M. Nishimura, S. Konno, E. Noguchi, 2017, Allergology international : official journal of the Japanese Society of Allergology.

Association Study of Matrix Metalloproteinase-12 Gene Polymorphisms and Asthma in a Japanese Population

Y. Okamoto, Hiroko Watanabe, A. Hata, 2012, International Archives of Allergy and Immunology.

SMAD3 as an atopic dermatitis susceptibility gene in the Japanese population.

T. Arinami, F. Otsuka, E. Noguchi, 2009, Journal of dermatological science.

Expression quantitative trait loci for ETV4 and MEOX1 are associated with adult asthma in Japanese populations

M. Tamari, T. Hirota, H. Masuko, 2021, Scientific Reports.

Genetics of allergic diseases

M. Tamari, T. Hirota, Shota Tanaka, 2012 .

High-frequency pulsed diode laser irradiation inhibits bone resorption in mice with ligature-induced periodontitis.

A. Aoki, T. Hirota, T. Iwata, 2022, Journal of clinical periodontology.