J. Buckner

发表

Notch signaling drives synovial fibroblast identity and arthritis pathology

N. Hacohen, C. Nusbaum, P. Gregersen, 2020, Nature.

Methods for high-dimensonal analysis of cells dissociated from cyropreserved synovial tissue

Shuqiang Li, N. Hacohen, C. Nusbaum, 2018, Arthritis Research & Therapy.

HLA class II tetramers: tools for direct analysis of antigen-specific CD4+ T cells.

H. Reijonen, J. Gebe, G. Nepom, 2002, Arthritis and rheumatism.

FOXP3 and the regulation of Treg/Th17 differentiation.

S. Ziegler, J. Buckner, Steven F Ziegler, 2009, Microbes and infection.

Erratum to: Understanding and preventing type 1 diabetes through the unique working model of TrialNet

Mark S. Anderson, Bart O. Roep, Carla J. Greenbaum, 2017, Diabetologia.

Negative regulation of TLR signaling in myeloid cells—implications for autoimmune diseases

Zhon-Yin Zhang, J. Buckner, J. Hamerman, 2016, Immunological reviews.

Mechanisms of impaired regulation by CD4+CD25+FOXP3+ regulatory T cells in human autoimmune diseases

J. Buckner, 2010, Nature Reviews Immunology.

Altered B Cell Homeostasis Is Associated with Type I Diabetes and Carriers of the PTPN22 Allelic Variant

E. L. Luning Prak, D. Rawlings, T. Habib, 2012, The Journal of Immunology.

B cell IFN-γ receptor signaling promotes autoimmune germinal centers via cell-intrinsic induction of BCL-6

D. Rawlings, S. Jackson, J. Buckner, 2016, The Journal of experimental medicine.

Increased levels of invariant natural killer T lymphocytes worsen metabolic abnormalities and atherosclerosis in obese mice

S. Subramanian, A. Chait, G. Getz, 2013, Journal of Lipid Research.

CD44 Costimulation Promotes FoxP3+ Regulatory T Cell Persistence and Function via Production of IL-2, IL-10, and TGF-β1

A. Preisinger, G. Nepom, J. Buckner, 2009, The Journal of Immunology.

Identification of type II collagen peptide 261-273-specific T cell clones in a patient with relapsing polychondritis.

W. Kwok, J. Buckner, Megan Van Landeghen, 2002, Arthritis and rheumatism.

Multiparameter Analysis Identifies Heterogeneity in Knee Osteoarthritis Synovial Responses

Kevin Macdonald, J. Buckner, Jonathan J. Clabeaux, 2019, Arthritis & rheumatology.

Optimization of Human T-Cell Expansion Ex Vivo Using Magnetic Beads Conjugated with Anti-CD3 and Anti-CD28 Antibodies

J. Buckner, R. Berenson, S. A. Long, 2004, Journal of immunotherapy.

Sudden Cardiac Death due to Coronary Artery Vasculitis in a Patient with Relapsing Polychondritis

J. Buckner, H. Bukiri, S. Ruhoy, 2020, Case reports in rheumatology.

Citrulline‐Specific Th1 Cells Are Increased in Rheumatoid Arthritis and Their Frequency Is Influenced by Disease Duration and Therapy

L. Klareskog, J. Gebe, E. James, 2014, Arthritis & rheumatology.

HLA autoimmune risk alleles restrict the hypervariable region of T cell receptors

S. Raychaudhuri, K. Ishigaki, Yang Luo, 2020, Nature Genetics.

The dynamic epigenetic regulation of the inactive X chromosome in healthy human B cells is dysregulated in lupus patients

M. Cancro, J. Buckner, Bam Paneru, 2020, Proceedings of the National Academy of Sciences.

Increased Binding of Specificity Protein 1 to the IL21R Promoter in B Cells Results in Enhanced B Cell Responses in Rheumatoid Arthritis

J. Buckner, Elizabeth M. Dam, A. Hocking, 2018, Front. Immunol..

Mechanism-driven strategies for prevention of rheumatoid arthritis.

J. Norris, W. Robinson, G. Firestein, 2022, Rheumatology & autoimmunity.

S1P1 deletion differentially affects TH17 and Regulatory T cells

E. Bettelli, M. Oukka, J. Buckner, 2017, Scientific Reports.

Anya Schneider Mediated Signaling − Involves IL-6 regsResistance to Adaptive T In Active Relapsing-Remitting Multiple Sclerosis , Effector T Cell

Chester Ni, K. Cerosaletti, J. Buckner, 2013 .

In Active Relapsing-Remitting Multiple Sclerosis, Effector T Cell Resistance to Adaptive Tregs Involves IL-6–Mediated Signaling

Chester Ni, K. Cerosaletti, J. Buckner, 2013, Science Translational Medicine.

RHEUMATIC DISEASES Immunological mechanisms and prospects for new therapies

D. Isenberg, K. Wucherpfennig, G. Nepom, 1999 .

Multi-omic Single-cell Atlas Reveals Broad Ex Vivo Effects on Human Immunobiology

J. Goldy, H. Bolouri, T. Torgerson, 2020, bioRxiv.

Evaluation of in vivo T cell kinetics: use of heavy isotope labelling in type 1 diabetes

M. Hellerstein, J. Buckner, C. Greenbaum, 2013, Clinical and experimental immunology.

HLA-DR1001 presents "altered-self" peptides derived from joint-associated proteins by accepting citrulline in three of its binding pockets.

E. James, W. Kwok, J. Buckner, 2010, Arthritis and rheumatism.

Strength in Numbers: Opportunities for Enhancing the Development of Effective Treatments for Type 1 Diabetes—The TrialNet Experience

J. Krischer, M. Atkinson, K. Herold, 2018, Diabetes.

Low HERV-K(C4) Copy Number Is Associated With Type 1 Diabetes

D. Chaussabel, V. Gersuk, G. Nepom, 2014, Diabetes.

Contains KAP 1 / TRIM 28 Chromatin-Remodeling Complex That Interacting Protein Couples FOXP 3 to a Cutting Edge : A Novel , Human-Specific and

S. Ziegler, J. Bluestone, J. Buckner, 2013 .

Cutting Edge: A Novel, Human-Specific Interacting Protein Couples FOXP3 to a Chromatin-Remodeling Complex That Contains KAP1/TRIM28

S. Ziegler, J. Bluestone, J. Buckner, 2013, The Journal of Immunology.

Induction of FoxP 3 and acquisition of T regulatory activity by stimulated human CD 4 + CD 25 – T cells

S. Ziegler, V. Gersuk, D. Kasprowicz, 2003 .

Lower omega-3 fatty acids are associated with the presence of anti-cyclic citrullinated peptide autoantibodies in a population at risk for future rheumatoid arthritis: a nested case-control study.

P. Gregersen, J. Norris, M. Weisman, 2016, Rheumatology.

Performance of anti-cyclic citrullinated Peptide assays differs in subjects at increased risk of rheumatoid arthritis and subjects with established disease.

P. Gregersen, J. Norris, M. Weisman, 2013, Arthritis and rheumatism.

Crosstalk between CD4 T cells and synovial fibroblasts from human arthritic joints promotes hyaluronan-dependent leukocyte adhesion and inflammatory cytokine expression in vitro

Christina K. Chan, I. Kang, G. Firestein, 2022, Matrix biology plus.

CD4+ Group 1 Innate Lymphoid Cells (ILC) Form a Functionally Distinct ILC Subset That Is Increased in Systemic Sclerosis

S. Ziegler, J. Bluestone, E. Whalen, 2016, The Journal of Immunology.

Correction: CD4+ Group 1 Innate Lymphoid Cells (ILC) Form a Functionally Distinct ILC Subset That Is Increased in Systemic Sclerosis

S. Ziegler, J. Bluestone, E. Whalen, 2016, The Journal of Immunology.

Genetic basis of defects in immune tolerance underlying the development of autoimmunity

J. Buckner, A. Hocking, 2022, Frontiers in Immunology.

Influence of FOXP3 on CD4+CD25+ regulatory T cells

S. Ziegler, J. Buckner, 2006, Expert review of clinical immunology.

CD4+FOXP3+ T Regulatory Cells in Human Autoimmunity: More Than a Numbers Game

J. Buckner, S. A. Long, 2011, The Journal of Immunology.

Functional islet‐specific Treg can be generated from CD4+CD25− T cells of healthy and type 1 diabetic subjects

E. James, G. Nepom, W. Kwok, 2009, European journal of immunology.

Evaluating associations of joint swelling, joint stiffness and joint pain with physical activity in first-degree relatives of patients with rheumatoid arthritis: Studies of the Aetiology of Rheumatoid Arthritis (SERA), a prospective cohort study

P. Gregersen, J. Norris, M. Weisman, 2021, BMJ Open.

Associations of joint swelling, joint stiffness, and joint pain with physical activity in first-degree relatives of patients with rheumatoid arthritis

P. Gregersen, J. Norris, M. Weisman, 2020, medRxiv.

Relatives without rheumatoid arthritis show reactivity to anti-citrullinated protein/peptide antibodies that are associated with arthritis-related traits: studies of the etiology of rheumatoid arthritis.

P. Gregersen, J. Norris, M. Weisman, 2013, Arthritis and rheumatism.

Differential Antigen Sensitivity and Costimulatory Requirements in Human Th1 and Th2 Antigen-Specific CD4+ Cells with Similar TCR Avidity 1

G. Nepom, W. Kwok, J. Buckner, 2003, The Journal of Immunology.

G. Nepom, W. Kwok, J. Buckner, 2022 .

Attenuated IL-2R signaling in CD4 memory T cells of T1D subjects is intrinsic and dependent on activation state.

M. Gavin, K. Cerosaletti, J. Buckner, 2017, Clinical immunology.

Citrullinated Aggrecan Epitopes as Targets of Autoreactive CD4+ T Cells in Patients With Rheumatoid Arthritis

K. Mikecz, E. James, J. Buckner, 2019, Arthritis & rheumatology.

Length Running head : Aggrecan as an RA autoantigen Title : Citrullinated Aggrecan Epitopes as Targets of Auto-reactive CD 4 + T cells in Patients with Rheumatoid Arthritis

K. Mikecz, E. James, J. Buckner, 2018 .

Identification and functional characterization of T cells reactive to citrullinated-vimentin in HLA-DRB1*0401 humanized mice and RA patients

J. Gebe, Betty B. Yue, G. Nepom, 2011 .

The Effector T Cells of Diabetic Subjects Are Resistant to Regulation via CD4+FOXP3+ Regulatory T Cells1

J. Buckner, C. Greenbaum, C. Pihoker, 2008, The Journal of Immunology.

Cell Signaling Associated with Autoimmunity Impairs B Cutting Edge: The PTPN22 Allelic Variant

T. Habib, Zhon-Yin Zhang, J. Buckner, 2009 .

Maintenance Pathways That Regulate Their Proliferation Regulatory T Cells , Disrupting Molecular Abatacept Targets T Follicular Helper and

Dawn, S. Khoury, E. Bettelli, 2019 .

Abatacept Targets T Follicular Helper and Regulatory T Cells, Disrupting Molecular Pathways That Regulate Their Proliferation and Maintenance

S. Khoury, E. Bettelli, L. Turka, 2019, The Journal of Immunology.

Rapamycin/IL-2 Combination Therapy in Patients With Type 1 Diabetes Augments Tregs yet Transiently Impairs β-Cell Function

J. Bluestone, A. Ahmann, L. Turka, 2012, Diabetes.

Identifying the ‘Achilles heel’ of type 1 diabetes

S. Richardson, M. Battaglia, M. Levings, 2020, Clinical and experimental immunology.

Defining antigen-specific responses with human MHC class II tetramers.

H. Reijonen, G. Nepom, W. Kwok, 2002, The Journal of allergy and clinical immunology.

Shifts in isoform usage underlie transcriptional differences in regulatory T cells in type 1 diabetes

Jeremy R. B. Newman, P. Concannon, K. Cerosaletti, 2022, bioRxiv.

Low-Dose Antigen Promotes Induction of FOXP3 in Human CD4+ T Cells

J. Buckner, P. Bollyky, R. Wu, 2011, The Journal of Immunology.

IL-6-Driven pSTAT1 Response Is Linked to T Cell Features Implicated in Early Immune Dysregulation

P. Linsley, K. Cerosaletti, J. Buckner, 2022, Frontiers in Immunology.

Circulating integrin alpha4/beta7+ lymphocytes targeted by vedolizumab have a pro-inflammatory phenotype.

J. Buckner, D. Shows, S. A. Long, 2018, Clinical immunology.

Dynamic Immune Phenotypes of B and T Helper Cells Mark Distinct Stages of T1D Progression

D. Rawlings, K. Cerosaletti, T. Habib, 2019, Diabetes.

Allelic Variant with Type I Diabetes and Carriers of the Altered B Cell Homeostasis Is Associated

Carla, D. Rawlings, T. Habib, 2011 .

A simple strategy for sample annotation error detection in cytometry datasets

V. Gersuk, J. Buckner, C. Speake, 2021, bioRxiv.

Plasma 25,OH Vitamin D Concentrations Are Not Associated with Rheumatoid Arthritis (RA)-related Autoantibodies in Individuals at Elevated Risk for RA

P. Gregersen, J. Norris, M. Weisman, 2009, Journal of Rheumatology.

Anticyclic Citrullinated Peptide Antibodies 3.1 and Anti-CCP-IgA Are Associated with Increasing Age in Individuals Without Rheumatoid Arthritis

P. Gregersen, J. Norris, M. Weisman, 2019, The Journal of Rheumatology.

Modulation of HLA-DQ binding properties by differences in class II dimer stability and pH-dependent peptide interactions.

G. Nepom, W. Kwok, J. Buckner, 1996, Journal of immunology.

Combination of rapamycin and IL-2 increases de novo induction of human CD4(+)CD25(+)FOXP3(+) T cells.

J. Buckner, S. A. Long, Jane H. Buckner, 2008, Journal of autoimmunity.

Active Translation Control of CD4 T Cell Activation by Regulatory T Cells

S. Ziegler, A. Takamori, J. Buckner, 2021, bioRxiv.

Dual IgA/IgG family autoantibodies from individuals at-risk for rheumatoid arthritis identify an arthritogenic strain of Subdoligranulum

W. Robinson, V. Holers, E. James, 2022, bioRxiv.

Pancreatic islet-specific engineered Tregs exhibit robust antigen-specific and bystander immune suppression in type 1 diabetes models

P. Linsley, D. Liggitt, D. Rawlings, 2022, Science Translational Medicine.

T Cells + FOXP3 in Human CD4 Low-Dose Antigen Promotes Induction of

J. Buckner, P. Bollyky, R. Wu, 2022 .

Immunotherapy: Building a bridge to a cure for type 1 diabetes

J. Bluestone, K. Herold, J. Buckner, 2021, Science.

CBLB Deficiency in Human CD4+ T Cells Results in Resistance to T Regulatory Suppression through Multiple Mechanisms

S. Ziegler, D. Rawlings, J. Buckner, 2022, The Journal of Immunology.

A novel and rapid method to quantify Treg mediated suppression of CD4 T cells.

J. Buckner, C. Mikacenic, A. E. Long, 2017, Journal of immunological methods.

Cutting Edge: Genetic Variation in TLR1 Is Associated with Pam3CSK4-Induced Effector T Cell Resistance to Regulatory T Cell Suppression

M. Wurfel, J. Buckner, C. Mikacenic, 2014, The Journal of Immunology.

Assessment of suppressive capacity by human regulatory T cells using a reproducible, bi-directional CFSE-based in vitro assay.

J. Buckner, A. Schneider, 2011, Methods in molecular biology.

Cutting Edge: High Molecular Weight Hyaluronan Promotes the Suppressive Effects of CD4+CD25+ Regulatory T Cells1

G. Nepom, J. Buckner, P. Bollyky, 2007, The Journal of Immunology.

Clonal IgA and IgG autoantibodies from individuals at risk for rheumatoid arthritis identify an arthritogenic strain of Subdoligranulum

W. Robinson, V. Holers, D. Frank, 2022, Science Translational Medicine.

Endomembrane targeting of human OAS1 p46 augments antiviral activity

Vineet D. Menachery, J. Baillie, K. Cerosaletti, 2021, bioRxiv.

B cell–derived IL-6 initiates spontaneous germinal center formation during systemic autoimmunity

D. Rawlings, S. Jackson, J. Buckner, 2017, The Journal of experimental medicine.

Distinct Heterogeneity in the Naive T cell Compartments of Children and Adults

Lucas T. Graybuck, E. Wherry, T. Torgerson, 2022, bioRxiv.

SAT0003 ELEVATED BASELINE AND INCREASING AUTOANTIBODY LEVELS ARE ASSOCIATED WITH INCREASED RISK FOR IMMINENT ONSET OF INFLAMMATORY ARTHRITIS IN A PROSPECTIVELY STUDIED ANTI-CITRULLINATED PROTEIN ANTIBODY POSITIVE COHORT: THE TIP-RA COLLECTIVE

W. Robinson, G. Firestein, V. Holers, 2020, Annals of the Rheumatic Diseases.

of CD4+CD25+ Regulatory T Cells Effects Hyaluronan Promotes the Suppressive Cutting Edge: High Molecular Weight

G. Nepom, J. Buckner, P. Bollyky, 2013 .

CD4+FOXP3+ T Regulatory Cells in Human Autoimmunity: More Than a Numbers Game

J. Buckner, S. A. Long, 2011, The Journal of Immunology.

IL-6–targeted therapies to block the cytokine or its receptor drive distinct alterations in T cell function

T. Habib, G. Nepom, J. Buckner, 2022, JCI Insight.

Neutrophil extracellular traps mediate articular cartilage damage and enhance cartilage component immunogenicity in rheumatoid arthritis.

V. Hoffmann, E. James, J. Buckner, 2020, JCI insight.

Type 1 diabetes immunotherapy using polyclonal regulatory T cells

Jeffrey A. Bluestone, Qizhi Tang, Shipra Gupta, 2015, Science Translational Medicine.

Association of Lipid Mediators With Development of Future Incident Inflammatory Arthritis in an Anti–Citrullinated Protein Antibody–Positive Population

P. Gregersen, J. Norris, M. Weisman, 2020, Arthritis & rheumatology.

IL-6: a cytokine at the crossroads of autoimmunity.

J. Buckner, B. Jones, M. Maerz, 2018, Current opinion in immunology.

Defects in IL-2R Signaling Contribute to Diminished Maintenance of FOXP3 Expression in CD4+CD25+ Regulatory T-Cells of Type 1 Diabetic Subjects

K. Cerosaletti, Zhon-Yin Zhang, J. Buckner, 2009, Diabetes.

Gene editing to induce FOXP3 expression in human CD4+ T cells leads to a stable regulatory phenotype and function

T. Torgerson, A. Scharenberg, D. Rawlings, 2020, Science Translational Medicine.

Synovial fibroblast-neutrophil interactions promote pathogenic adaptive immunity in rheumatoid arthritis

W. Robinson, V. Hoffmann, P. Thompson, 2017, Science Immunology.

Induction of FoxP3 and acquisition of T regulatory activity by stimulated human CD4+CD25- T cells.

S. Ziegler, V. Gersuk, D. Kasprowicz, 2003, The Journal of clinical investigation.

The PTPN22 allele encoding an R620W variant interferes with the removal of developing autoreactive B cells in humans.

P. Gregersen, C. Abraham, E. Meffre, 2011, The Journal of clinical investigation.

Genetic Variation in PTPN22 Corresponds to Altered Function of T and B Lymphocytes1

P. Concannon, S. Onengut-Gumuscu, J. Buckner, 2007, The Journal of Immunology.

Genetic Variation in PTPN 22 Corresponds to Altered Function of T and B Lymphocytes 1

P. Concannon, S. Onengut-Gumuscu, J. Buckner, 2007 .

Multimodal analysis for human ex vivo studies shows extensive molecular changes from delays in blood processing

J. Goldy, H. Bolouri, T. Torgerson, 2020, iScience.

Efficient ex vivo analysis of CD4+ T-cell responses using combinatorial HLA class II tetramer staining

E. James, W. Kwok, J. Buckner, 2016, Nature Communications.

Fine-mapping, trans-ancestral, and genomic analyses identify causal variants, cells, genes, and drug targets for type 1 diabetes

Amy S. Shah, Catherine C. Robertson, P. Deloukas, 2020, Nature Genetics.

IL-6 receptor blockade does not slow β cell loss in new-onset type 1 diabetes

Darrell M. Wilson, J. Gaglia, P. Raskin, 2021, JCI insight.

Obstacles and opportunities for targeting the effector T cell response in type 1 diabetes.

G. Nepom, J. Buckner, 2016, Journal of autoimmunity.

Enhanced T cell responses to IL-6 in type 1 diabetes are associated with early clinical disease and increased IL-6 receptor expression

K. Cerosaletti, E. Whalen, J. Buckner, 2016, Science Translational Medicine.

Defining inflammatory cell states in rheumatoid arthritis joint synovial tissues by integrating single-cell transcriptomics and mass cytometry

Nir Hacohen, Kamil Slowikowski, Andrew Filer, 2019, Nature Immunology.

Recognition of altered self major histocompatibility complex molecules modulated by specific peptide interactions

T. Lybrand, G. Nepom, J. Buckner, 1996, European journal of immunology.

Multiple Autoimmune-Associated Variants Confer Decreased IL-2R Signaling in CD4+CD25hi T Cells of Type 1 Diabetic and Multiple Sclerosis Patients

Elizabeth Whalen, Ian Frank, I. Frank, 2013, PloS one.

An autoimmune-associated variant in PTPN2 reveals an impairment of IL-2R signaling in CD4+ T cells

K. Cerosaletti, J. Buckner, Shan Wei, 2010, Genes and Immunity.

HLA-DRB1 risk alleles for RA are associated with differential clinical responsiveness to abatacept and adalimumab: data from a head-to-head, randomized, single-blind study in autoantibody-positive early RA

V. Bykerk, J. Buckner, N. Ray, 2021, Arthritis Research & Therapy.

IL-2 therapy in type 1 diabetes: "Trials" and tribulations.

J. Buckner, C. Greenbaum, S. A. Long, 2013, Clinical immunology.

Rheumatoid arthritis and the mucosal origins hypothesis: protection turns to destruction

J. Norris, W. Robinson, V. Holers, 2018, Nature Reviews Rheumatology.

Coordinated Induction of Antimicrobial Response Factors in Systemic Lupus Erythematosus

N. Sarvetnick, J. Buckner, Robert Z. Harms, 2019, Front. Immunol..

A disease-associated PTPN22 variant promotes systemic autoimmunity in murine models.

R. Moon, D. Liggitt, Alejandro Wolf-Yadlin, 2013, The Journal of clinical investigation.

The Autoimmune Risk Variant PTPN22 C1858T Alters B Cell Tolerance at Discrete Checkpoints and Differentially Shapes the Naive Repertoire

Genita Metzler, D. Rawlings, T. Habib, 2017, The Journal of Immunology.

Early Prognostic Indicators of Subsequent Hospitalization in Patients with Mild COVID-19

J. Buckner, Aaron Rips, U. Malhotra, 2021, Journal of clinical medicine.

A prospective approach to investigating the natural history of preclinical rheumatoid arthritis (RA) using first-degree relatives of probands with RA.

P. Gregersen, J. Norris, M. Weisman, 2009, Arthritis and rheumatism.

The problems and promises of research into human immunology and autoimmune disease

S. Sawcer, F. Zipp, R. Toes, 2012, Nature Medicine.

Functional Analysis of FOXP3

S. Ziegler, J. Buckner, 2008, Annals of the New York Academy of Sciences.

T Cell Selection and Differential Activation on Structurally Related HLA-DR4 Ligands1

J. Gebe, G. Nepom, W. Kwok, 2001, The Journal of Immunology.

G. Nepom, W. Kwok, J. Buckner, 2001 .

Mice expressing HLA-DQ6α8β transgenes develop polychondritis spontaneously

J. Buckner, C. David, D. Bradley, 2006, Arthritis research & therapy.

Intersection between genetic polymorphisms and immune deviation in type 1 diabetes

J. Buckner, A. Long, 2013, Current opinion in endocrinology, diabetes, and obesity.

C URRENT OPINION Intersection between genetic polymorphisms and immune deviation in type 1 diabetes

J. Buckner, A. Long, 2013 .

Clinical and experimental treatment of type 1 diabetes

J. Buckner, S. A. Long, 2022, Clinical and experimental immunology.

A Haplotype-Based Analysis of the PTPN22 Locus in Type 1 Diabetes

P. Concannon, S. Onengut-Gumuscu, J. Buckner, 2006, Diabetes.

Complement receptor 2/CD21- human naive B cells contain mostly autoreactive unresponsive clones.

C. Cunningham-Rundles, E. Meffre, J. Buckner, 2010, Blood.

Low-dose interleukin-2 fosters a dose-dependent regulatory T cell tuned milieu in T1D patients.

D. Klatzmann, A. Hartemann, T. Malek, 2015, Journal of autoimmunity.

Fewer LAG-3+ T Cells in Relapsing-Remitting Multiple Sclerosis and Type 1 Diabetes.

J. Buckner, C. Speake, H. Bahnson, 2022, Journal of immunology.

The A946T variant IFIH1 RNA sensor mediates an interferon program that limits viral infection but increases the risk for autoimmunity

D. Liggitt, P. Concannon, D. Rawlings, 2017, Nature Immunology.

De novo generation of antigen-specific CD4+CD25+ regulatory T cells from human CD4+CD25- cells.

S. Ziegler, G. Nepom, B. Carson, 2005, Proceedings of the National Academy of Sciences of the United States of America.

Identification of novel HLA class II target epitopes for generation of donor-specific T regulatory cells.

J. Shendure, A. Kas, J. Buckner, 2012, Clinical immunology.

Understanding and preventing type 1 diabetes through the unique working model of TrialNet

Mark S. Anderson, Mark Peakman, Manuela Battaglia, 2017, Diabetologia.

Autoreactivity against matrilin-1 in a patient with relapsing polychondritis.

D. Eyre, J. Buckner, Jiann-Jiu Wu, 2000, Arthritis and rheumatism.

Combined analysis of monocyte and lymphocyte messenger RNA expression with serum protein profiles in patients with scleroderma.

D. Pritchard, S. Schwartz, K. Elkon, 2008, Arthritis and rheumatism.

Lineage and signal strength determine the inhibitory effect of transforming growth factor beta1 (TGF-beta1) on human antigen-specific Th1 and Th2 memory cells.

J. Buckner, U. Holzer, M. Rieck, 2006, Journal of autoimmunity.

A functional framework for interpretation of genetic associations in T1D.

G. Nepom, J. Buckner, 2012, Current opinion in immunology.

Novel APC-like properties of human NK cells directly regulate T cell activation

J. Hanna, O. Mandelboim, D. Mevorach, 2015, bioRxiv.

Shared recognition of citrullinated tenascin-C peptides by T and B cells in rheumatoid arthritis

E. James, J. Buckner, V. Malmström, 2021, JCI insight.

Memory T cells specific to citrullinated α-enolase are enriched in the rheumatic joint.

L. Rönnblom, L. Klareskog, A. Dubnovitsky, 2018, Journal of autoimmunity.

Identification and functional characterization of T cells reactive to citrullinated vimentin in HLA-DRB1*0401-positive humanized mice and rheumatoid arthritis patients.

J. Gebe, Betty B. Yue, G. Nepom, 2011, Arthritis and rheumatism.

The heat shock protein Hsp70 enhances antigen‐specific proliferation of human CD4+ memory T cells

H. Kalbacher, W. Kwok, J. Buckner, 2005, European journal of immunology.

The heat shock protein Hsp 70 enhances antigen-specific proliferation of human CD 4 + memory T cells

H. Kalbacher, W. Kwok, J. Buckner, 2005 .

Use of class II tetramers for identification of CD4+ T cells.

Andrew W. Liu, W. Kwok, J. Buckner, 2002, Journal of immunological methods.

Multifunctional T cell reactivity with native and glycosylated type II collagen in rheumatoid arthritis.

Ida E. Andersson, L. Klareskog, R. Holmdahl, 2012, Arthritis and rheumatism.

Low-dose interleukin-2 fosters a dose-dependent regulatory T cell tuned milieu in T 1 D patients Running head : dose-dependent low dose IL-2 immunoregulation

D. Klatzmann, A. Hartemann, T. Malek, 2017 .

The TYK2-P1104A Autoimmune Protective Variant Limits Coordinate Signals Required to Generate Specialized T Cell Subsets

D. Rawlings, M. Oukka, K. Cerosaletti, 2019, Front. Immunol..

Regulating the immune system: the induction of regulatory T cells in the periphery

S. Ziegler, J. Buckner, 2004, Arthritis research & therapy.

Porphyromonas gingivalis and disease-related autoantibodies in individuals at increased risk of rheumatoid arthritis.

P. Gregersen, H. Sayles, J. Norris, 2012, Arthritis and rheumatism.

The PTPN22 allelic variant associated with autoimmunity impairs B cell signaling

J. Buckner, A. Arechiga, 2008, The Journal of Immunology.

Distinct T cell signatures define subsets of patients with multiple sclerosis

J. Goverman, A. Nielsen, J. Buckner, 2016, Neurology: Neuroimmunology & Neuroinflammation.

Protein Tyrosine Phosphatases and Type 1 Diabetes : Genetic and Functional Implications of PTPN 2 and PTPN 22

K. Cerosaletti, J. Buckner, 2013 .

Protein tyrosine phosphatases and type 1 diabetes: genetic and functional implications of PTPN2 and PTPN22.

K. Cerosaletti, J. Buckner, 2012, The review of diabetic studies : RDS.

Deep immune phenotyping reveals similarities between aging, Down syndrome, and autoimmunity

Kaitlin J. Flynn, P. Linsley, V. Gersuk, 2022, Science Translational Medicine.

Permutational immune analysis reveals architectural similarities between inflammaging, Down syndrome and autoimmunity

Kaitlin J. Flynn, J. Buckner, C. Greenbaum, 2021, bioRxiv.

Diminished responses to mRNA-based SARS-CoV-2 vaccines in individuals with rheumatoid arthritis on immune-modifying therapies

E. Bettelli, M. Wener, D. Campbell, 2023, medRxiv.

Genetics of rheumatoid arthritis: is there a scientific explanation for the human leukocyte antigen association?

G. Nepom, J. Buckner, 2002, Current opinion in rheumatology.

Immunity to T cell receptor peptides in multiple sclerosis. III. Preferential immunogenicity of complementarity-determining region 2 peptides from disease-associated T cell receptor BV genes.

D. Bourdette, G. Nepom, A. Vandenbark, 1998, Journal of immunology.

Genes * from Disease-Associated T Cell Receptor BV Complementarity-Determining Region 2 Peptides Sclerosis . III . Preferential Immunogenicity of Immunity to T Cell Receptor Peptides in Multiple

D. Bourdette, G. Nepom, A. Vandenbark, 1998 .

Autoantibodies against Neurologic Antigens in Nonneurologic Autoimmunity

D. Hafler, J. Guthridge, V. Holers, 2019, The Journal of Immunology.

The Relapsing Polychondritis Disease Activity Index: development of a disease activity score for relapsing polychondritis.

R. Moots, D. Scott, Toshio Tanaka, 2012, Autoimmunity reviews.

Relationship between air pollution and positivity of RA-related autoantibodies in individuals without established RA: a report on SERA

P. Gregersen, J. Norris, M. Weisman, 2013, Annals of the rheumatic diseases.

A Contra Capture Protein Array Platform for Studying Post-translationally Modified (PTM) Auto-antigenomes*

Peter Wiktor, Joshua LaBaer, Kailash Karthikeyan, 2016, Molecular & Cellular Proteomics.

Cytotoxic CD8+ T cells target citrullinated antigens in rheumatoid arthritis

W. Robinson, L. Donlin, S. Goodman, 2022, Nature Communications.

The BANK1 SLE-risk variants are associated with alterations in peripheral B cell signaling and development in humans.

Veronika A. Glukhova, K. Cerosaletti, R. James, 2016, Clinical immunology.

Transcript array analysis in rheumatology.

G. Nepom, J. Buckner, J. Molitor, 2002, Rheumatic diseases clinics of North America.

AI-18 B cell IFN-γ receptor signalling promotes autoimmune germinal centresvia cell-intrinsic induction of BCL-6

D. Rawlings, S. Jackson, J. Buckner, 2016, Lupus Science & Medicine.

Impact of Age and Antibody Type on Progression From Single to Multiple Autoantibodies in Type 1 Diabetes Relatives

P. Bingley, A. Steck, D. Boulware, 2017, The Journal of clinical endocrinology and metabolism.

Associations of Smoking and Age With Inflammatory Joint Signs Among Unaffected First‐Degree Relatives of Rheumatoid Arthritis Patients: Results From Studies of the Etiology of Rheumatoid Arthritis

P. Gregersen, J. Norris, Shun-Chiao Chang, 2016, Arthritis & rheumatology.

Cutting Edge: The PTPN22 Allelic Variant Associated with Autoimmunity Impairs B Cell Signaling1

T. Habib, Zhon-Yin Zhang, J. Buckner, 2009, The Journal of Immunology.

T Cells Contain an RNase-Insensitive Inhibitor of APOBEC3G Deaminase Activity

Lorne W. Walker, K. C. Klein, J. Lingappa, 2007, PLoS pathogens.

FOXP 3 and the regulation of Treg / Th 17 differentiation

S. Ziegler, J. Buckner, 2009 .

SARS-CoV-2 mRNA vaccines decouple anti-viral immunity from humoral autoimmunity

A. Ring, J. Buckner, C. Lucas, 2023, Nature Communications.

SAT0082 ASSOCIATIONS OF BASELINE CLINICAL AND BIOMARKER FACTORS WITH SYMPTOMS AND FUTURE DEVELOPMENT OF CLINICALLY-APPARENT RHEUMATOID ARTHRITIS IN AN ACPA POSITIVE COHORT

W. Robinson, G. Firestein, D. Boyle, 2019, SATURDAY, 15 JUNE 2019.

Functional and Structural Characterization of a Novel HLA-DRB1*04:01-Restricted α-Enolase T Cell Epitope in Rheumatoid Arthritis

R. Zubarev, L. Rönnblom, A. Ytterberg, 2016, Front. Immunol..

Genetic Mechanisms Highlight Shared Pathways for the Pathogenesis of Polygenic Type 1 Diabetes and Monogenic Autoimmune Diabetes

K. Cerosaletti, S. Flanagan, J. Buckner, 2019, Current Diabetes Reports.

The COVID-19 immune landscape is dynamically and reversibly correlated with disease severity

H. Bolouri, D. Campbell, J. Buckner, 2020, bioRxiv.

Th17 cells: from gut homeostasis to CNS pathogenesis

O. Harrison, J. Buckner, 2022, Trends in Immunology.

Multiple cytokines and chemokines are associated with rheumatoid arthritis-related autoimmunity in first-degree relatives without rheumatoid arthritis: Studies of the Aetiology of Rheumatoid Arthritis (SERA)

P. Gregersen, J. Norris, M. Weisman, 2012, Annals of the rheumatic diseases.

Response to comment on “Synovial fibroblast-neutrophil interactions promote pathogenic adaptive immunity in rheumatoid arthritis”

W. Robinson, P. Thompson, J. Buckner, 2018, Science Immunology.

The Effect of Ethnicity in the Rate of Beta Cell Functional Loss in the First 3 Years After Type 1 Diabetes Diagnosis.

Kathleen C. Fraser, Mark S. Anderson, Renee A. Davis, 2020, The Journal of clinical endocrinology and metabolism.

The Role of PTPN22 Risk Variant in the Development of Autoimmunity: Finding Common Ground between Mouse and Human

D. Rawlings, X. Dai, J. Buckner, 2015, The Journal of Immunology.

Cutting Edge Cutting Edge : The PTPN 22 Allelic Variant Associated with Autoimmunity Impairs B Cell Signaling 1

T. Habib, Zhon-Yin Zhang, J. Buckner, 2009 .

Latent autoimmunity across disease-specific boundaries in at-risk first-degree relatives of SLE and RA patients

P. Gaffney, J. Norris, C. Langefeld, 2019, EBioMedicine.

Peripheral and Site‐Specific CD4+CD28null T Cells from Rheumatoid Arthritis Patients Show Distinct Characteristics

J. Buckner, V. Malmström, O. Snir, 2014, Scandinavian journal of immunology.

S1P1 deletion differentially affects TH17 and Regulatory T cells

E. Bettelli, M. Oukka, J. Buckner, 2016, Scientific Reports.

Omega-3 fatty acids are associated with a lower prevalence of autoantibodies in shared epitope-positive subjects at risk for rheumatoid arthritis

P. Gregersen, J. Norris, M. Weisman, 2016, Annals of the rheumatic diseases.

Dysregulated IFN-γ signals promote autoimmunity in STAT1 gain-of-function syndrome

T. Torgerson, D. Rawlings, E. Allenspach, 2023, Science Translational Medicine.

The Autoimmune Risk R262W Variant of the Adaptor SH2B3 Improves Survival in Sepsis.

M. Wurfel, D. Liggitt, D. Rawlings, 2021, Journal of Immunology.

Perceived Stress and Inflammatory Arthritis: A Prospective Investigation in the Studies of the Etiologies of Rheumatoid Arthritis Cohort

P. Gregersen, J. Norris, P. Nicassio, 2020, Arthritis care & research.

Targeted Deep Sequencing in Multiple-Affected Sibships of European Ancestry Identifies Rare Deleterious Variants in PTPN22 That Confer Risk for Type 1 Diabetes

A. Quinlan, A. Mackey, S. Rich, 2015, Diabetes.

Factors associated with progression to inflammatory arthritis in first-degree relatives of individuals with RA following autoantibody positive screening in a non-clinical setting

P. Gregersen, J. Norris, M. Weisman, 2020, Annals of the Rheumatic Diseases.

PTPN22 R620W gene editing in T cells enhances low-avidity TCR responses

P. Linsley, D. Rawlings, K. Cerosaletti, 2022, bioRxiv.

Erratum: CD4+ Group 1 Innate Lymphoid CD4+ Group 1 Innate Lymphoid Subset That Is Increased in Systemic Sclerosis (Journal of Immunology (2016) 196 (2051-2062))

S. Ziegler, J. Bluestone, E. Whalen, 2016 .

Stacking the Deck: Studies of Patients with Multiple Autoimmune Diseases Propelled Our Understanding of Type 1 Diabetes as an Autoimmune Disease

J. Buckner, C. Greenbaum, 2017, The Journal of Immunology.

Cutting Edge: Effect of Disease-Modifying Therapies on SARS-CoV-2 Vaccine–Induced Immune Responses in Multiple Sclerosis Patients

E. Bettelli, M. Wener, D. Campbell, 2022, The Journal of Immunology.

Down syndrome: insights into autoimmune mechanisms

J. Buckner, B. Khor, 2023, Nature Reviews Rheumatology.

J. Buckner, A. Hocking, Namrata Singh, 2023, Immunological reviews.

IL-6–targeted therapies to block the cytokine or its receptor drive distinct alterations in T cell function

T. Habib, G. Nepom, J. Buckner, 2022 .

Regulatory T cells suppress CD4+ effector T cell activation by controlling protein synthesis

S. Ziegler, A. Takamori, J. Buckner, 2023, Journal of Experimental Medicine.