A. Cooper

C. Bonorino, I. Orme, A. Cooper, 1997, Tubercle and lung disease : the official journal of the International Union against Tuberculosis and Lung Disease.

What Do We Really Know about How CD4 T Cells Control Mycobacterium tuberculosis?

A. Cooper, E. Torrado, 2011, PLoS pathogens.

Antimycobacterial action of thiolactomycin: an inhibitor of fatty acid and mycolic acid synthesis

G. Besra, I. Orme, P. Brennan, 1996, Antimicrobial agents and chemotherapy.

TB day summit in upstate New York: Key issues to address

G. Kaplan, A. Cooper, K. Derbyshire, 2009, European journal of immunology.

Lymphotoxin beta receptor signaling limits mucosal damage through driving IL-23 production by epithelial cells

yang-xin fu, Michael Tighe, A. Cooper, 2014, Mucosal Immunology.

An oily, sustained counter-regulatory response to TB.

C. Karp, A. Cooper, 2005, The Journal of clinical investigation.

Yersinia pestis Evades TLR4-dependent Induction of IL-12(p40)2 by Dendritic Cells and Subsequent Cell Migration1

R. Locksley, E. Lien, S. Khader, 2008, The Journal of Immunology.

Opposing biological functions of tryptophan catabolizing enzymes during intracellular infection.

G. Prendergast, D. Munn, C. Karp, 2012, The Journal of infectious diseases.

Mouse model of tuberculosis.

A. Cooper, 2015, Cold Spring Harbor perspectives in medicine.

In Vivo IL-10 Production Reactivates Chronic Pulmonary Tuberculosis in C57BL/6 Mice1

I. Orme, A. Kipnis, M. Gonzalez-Juarrero, 2002, The Journal of Immunology.

Analysis of Lsh gene expression in congenic B10.L-Lshr mice.

J. Blackwell, T. Roach, M. King, 1988, Current topics in microbiology and immunology.

The study of Mycobacterium leprae infection in interferon-gamma gene--disrupted mice as a model to explore the immunopathologic spectrum of leprosy.

I. Orme, A. Cooper, D. Scollard, 2002, The Journal of infectious diseases.

Disruption of the Cellular Inflammatory Response to Listeria monocytogenes Infection in Mice with Disruptions in Targeted Genes

J. Burke, Alan D. Roberts, I. Orme, 1998, Infection and Immunity.

In a Murine Tuberculosis Model, the Absence of Homeostatic Chemokines Delays Granuloma Formation and Protective Immunity1

T. Randall, J. Rangel-Moreno, S. Khader, 2009, The Journal of Immunology.

In a Murine Tuberculosis Model, the Absence of Homeostatic Chemokines Delays Granuloma Formation and Protective Immunity1

T. Randall, J. Rangel-Moreno, S. Khader, 2009, The Journal of Immunology.

Cutting Edge: T-bet and IL-27R Are Critical for In Vivo IFN-γ Production by CD8 T Cells during Infection1

S. Wittmer, J. Kohlmeier, D. Woodland, 2008, The Journal of Immunology.

Neutrophils Play a Protective Nonphagocytic Role in Systemic Mycobacterium tuberculosis Infection of Mice

R. Appelberg, I. Orme, B. Saunders, 2000, Infection and Immunity.

Intracellular trafficking in Mycobacterium tuberculosis and Mycobacterium avium-infected macrophages.

I. Orme, A. Cooper, D. Chatterjee, 1994, Journal of immunology.

Mycobacterium tuberculosis infection induces il12rb1 splicing to generate a novel IL-12Rβ1 isoform that enhances DC migration

S. Khader, D. Woodland, A. Cooper, 2010, The Journal of Experimental Medicine.

Mycobacterium tuberculosis infection induces il12rb1 splicing to generate a novel IL-12Rβ1 isoform that enhances DC migration

S. Khader, D. Woodland, A. Cooper, 2010, The Journal of experimental medicine.

IL-17A Promotes Intracellular Growth of Mycobacterium by Inhibiting Apoptosis of Infected Macrophages

R. Appelberg, J. Pedrosa, M. Saraiva, 2015, Front. Immunol..

CD157 Confers Host Resistance to Mycobacterium tuberculosis via TLR2-CD157-PKCzeta-Induced Reactive Oxygen Species Production

Xinchun Chen, K. Ishihara, A. Yahagi, 2019, mBio.

the IL-12 p40 Subunit Is Present Responses to Mycobacterial Infection Only if Protective, Antigen-Specific Cellular Mice Lacking Bioactive IL-12 Can Generate

I. Orme, A. Kipnis, A. Cooper, 2002 .

Role of gamma delta T cells in immunopathology of pulmonary Mycobacterium avium infection in mice.

I. Orme, B. Saunders, A. Cooper, 1998, Infection and immunity.

IL-23 Is Required for Long-Term Control of Mycobacterium tuberculosis and B Cell Follicle Formation in the Infected Lung

J. Kolls, T. Randall, R. Gopal, 2011, The Journal of Immunology.

TNFα and IFNγ but Not Perforin Are Critical for CD8 T Cell-Mediated Protection against Pulmonary Yersinia pestis Infection

J. Bliska, A. Cooper, Jr-Shiuan Lin, 2014, PLoS pathogens.

A Persistent Tuberculosis Outbreak in the UK Is Characterized by Hydrophobic fadB4-Deficient Mycobacterium tuberculosis That Replicates Rapidly in Macrophages

N. Garton, M. Barer, H. O’Hare, 2022, mBio.

Expression of LPG and GP63 by different developmental stages of Leishmania major in the sandfly Phlebotomus papatasi

J. Blackwell, C. Davies, A. Cooper, 1990, Parasitology.

Innate IFN-γ–Producing Cells Developing in the Absence of IL-2 Receptor Common γ-Chain

R. Appelberg, M. Flórido, M. Borges, 2017, The Journal of Immunology.

This information is current as-Chain γ the Absence of IL-2 Receptor Common Producing Cells Developing in − γ Innate IFN -

R. Appelberg, M. Flórido, M. Borges, 2017 .

Old mice are able to control low-dose aerogenic infections with Mycobacterium tuberculosis

Alan D. Roberts, I. Orme, A. Cooper, 1995, Infection and immunity.

IL-27 Signaling Compromises Control of Bacterial Growth in Mycobacteria-Infected Mice1

S. Khader, A. Cooper, N. Ghilardi, 2004, The Journal of Immunology.

T cells in mycobacterial infection and disease.

A. Cooper, 2009, Current opinion in immunology.

Evidence for a reduced chemokine response in the lungs of beige mice infected with Mycobacterium avium

R. Appelberg, I. Orme, M. Flórido, 1997, Immunology.

Interleukin 12 (IL-12) Is Crucial to the Development of Protective Immunity in Mice Intravenously Infected with Mycobacterium tuberculosis

I. Orme, A. Cooper, J. Magram, 1997, The Journal of experimental medicine.

Cu,Zn Superoxide Dismutase of Mycobacterium tuberculosis Contributes to Survival in Activated Macrophages That Are Generating an Oxidative Burst

T. Laessig, F. Fang, I. Orme, 2001, Infection and Immunity.

Cytokines and Chemokines in Mycobacterium tuberculosis Infection

S. Khader, A. Cooper, O. Prince, 2016, Microbiology spectrum.

Is IL-17 required to control tuberculosis?

A. Cooper, 2009 .

Materials and Methods Briefdefinitive Report Disseminated Tuberculosis in Interferon 7 Gene-disrupted Mice

I. Orme, A. Cooper, D. Russell, 2022 .

Inflammation and lymphocyte activation during mycobacterial infection in the interferon-gamma-deficient mouse.

S. Ehlers, I. Orme, B. Saunders, 2001, Cellular immunology.

Disseminated tuberculosis in interferon gamma gene-disrupted mice

I. Orme, A. Cooper, D. Russell, 1993, The Journal of experimental medicine.

Animal Models of Tuberculosis

W. Bishai, J. Flynn, A. Cooper, 2005 .

Macrophage signalling upon mycobacterial infection: the MAP kinases lead the way

A. Cooper, J. Schorey, 2003, Cellular microbiology.

IL-12 and IL-23 cytokines: from discovery to targeted therapies for immune-mediated inflammatory diseases

J. McElwee, J. Casanova, M. Smyth, 2015, Nature Medicine.

IFN-gamma and NO in mycobacterial disease: new jobs for old hands.

S. Ehlers, R. Appelberg, A. Cooper, 2002, Trends in microbiology.

The balance between protective and pathogenic immune responses in the TB-infected lung

I. Orme, A. Cooper, R. Robinson, 2014, Nature Immunology.

IL-17 and Th17 cells in tuberculosis.

A. Cooper, E. Torrado, 2010, Cytokine & growth factor reviews.

Monoclonal antibodies that recognize distinct epitopes of the macrophage type three complement receptor differ in their ability to inhibit binding of Leishmania promastigotes harvested at different phases of their growth cycle.

J. Blackwell, A. Cooper, H. Rosen, 1988, Immunology.

Infection with Mycobacterium tuberculosis induces the Warburg effect in mouse lungs

H. Salamon, M. Gennaro, E. Eugenin, 2015, Scientific Reports.

Impairment of immunity to Candida and Mycobacterium in humans with bi-allelic RORC mutations

J. Casanova, A. Sette, L. Notarangelo, 2015, Science.

Cell-mediated immune responses in tuberculosis.

A. Cooper, Andrea M Cooper, 2009, Annual review of immunology.

IL-23 and IL-17 in the establishment of protective pulmonary CD4+ T cell responses after vaccination and during Mycobacterium tuberculosis challenge

R. Locksley, S. Gaffen, T. Randall, 2007, Nature Immunology.

Location, Location, Location: The Impact of Migratory Heterogeneity on T Cell Function

B. Baaten, L. Bradley, S. Swain, 2013, Front. Immunol..

Interleukin-12 and tuberculosis: an old story revisited.

S. Khader, A. Cooper, A. Solache, 2007, Current opinion in immunology.

Quantification and prognostic significance of interferon-γ secreting SARS-CoV-2 responsive T cells in hospitalized patients with acute COVID-19

M. Barer, J. W. Kim, C. A. Martin, 2021, Journal of Infection.

Intact type 1 immunity and immune-associated coagulative responses in mice lacking IFN gamma-inducible fibrinogen-like protein 2.

In-Jeong Kim, M. Blackman, D. Woodland, 2004, Proceedings of the National Academy of Sciences of the United States of America.

The role of interleukin-12 in acquired immunity to Mycobacterium tuberculosis infection.

Alan D. Roberts, I. Orme, E. R. Rhoades, 1995, Immunology.

IL-12p40: an inherently agonistic cytokine.

S. Khader, A. Cooper, 2007, Trends in immunology.

Mice Lacking Bioactive IL-12 Can Generate Protective, Antigen-Specific Cellular Responses to Mycobacterial Infection Only if the IL-12 p40 Subunit Is Present1

I. Orme, A. Kipnis, A. Cooper, 2002, The Journal of Immunology.

IL-23 and IL-17 in tuberculosis.

S. Khader, A. Cooper, 2008, Cytokine.

Restraining mycobacteria: Role of granulomas in mycobacterial infections

B. Saunders, A. Cooper, Bernadette M Saunders, 2000, Immunology and cell biology.

Cytokine/chemokine cascades in immunity to tuberculosis.

I. Orme, A. Cooper, 1999, Immunology today.

Tc17, a Unique Subset of CD8 T Cells That Can Protect against Lethal Influenza Challenge1

T. Strutt, S. Swain, K. McKinstry, 2009, The Journal of Immunology.

Transient Loss of Resistance to Pulmonary Tuberculosis in p 47 phox 2 / 2 Mice

S. Holland, I. Orme, A. Cooper, 2000 .

THEMIS Is Required for Pathogenesis of Cerebral Malaria and Protection against Pulmonary Tuberculosis

M. Lathrop, J. Berghout, P. Gros, 2014, Infection and Immunity.

Regulation of mitogen-activated protein kinase signaling pathway and proinflammatory cytokines by ursolic acid in murine macrophages infected with Mycobacterium avium

A. Cooper, E. Sukandar, D. Pitaloka, 2020, Infectious disease reports.

Early T‐cell responses in tuberculosis immunity

D. Woodland, A. Cooper, G. Winslow, 2008, Immunological reviews.

Expression of the Nitric Oxide Synthase 2 Gene Is Not Essential for Early Control of Mycobacterium tuberculosis in the Murine Lung

S. Ehlers, I. Orme, A. Cooper, 2000, Infection and Immunity.

Cytokines in the balance of protection and pathology during mycobacterial infections.

A. Cooper, E. Torrado, Andrea M Cooper, 2013, Advances in experimental medicine and biology.

Editorial: Be careful what you ask for: is the presence of IL‐17 indicative of immunity?

A. Cooper, 2010, Journal of leukocyte biology.

IL‐27 enhances LPS‐induced IL‐1β in human monocytes and murine macrophages

B. Banfield, C. Petes, K. Gee, 2017, Journal of leukocyte biology.

Differential and Site Specific Impact of B Cells in the Protective Immune Response to Mycobacterium tuberculosis in the Mouse

J. Rangel-Moreno, A. Cooper, E. Torrado, 2013, PloS one.

Immunological Basis for Reactivation of Tuberculosis in Mice

I. Orme, M. Gonzalez-Juarrero, B. Saunders, 2001 .

IL‐17 and anti‐bacterial immunity: Protection versus tissue damage

A. Cooper, 2009, European journal of immunology.

Effector CD4 T cell transition to memory requires late cognate interactions that induce autocrine IL-2

Wenlian Zhang, T. Strutt, S. Swain, 2014, Nature Communications.

Memory CD4 T cell-derived IL-2 synergizes with viral infection to exacerbate lung inflammation

F. Alam, S. Sell, T. Strutt, 2019, PLoS pathogens.

Interleukin 27R regulates CD4+ T cell phenotype and impacts protective immunity during Mycobacterium tuberculosis infection

Rachel P. J. Lai, Xinchun Chen, D. Zak, 2015, The Journal of experimental medicine.

The onset of adaptive immunity in the mouse model of tuberculosis and the factors that compromise its expression

I. Orme, A. Cooper, R. Robinson, 2015, Immunological reviews.

IL-23 Compensates for the Absence of IL-12p70 and Is Essential for the IL-17 Response during Tuberculosis but Is Dispensable for Protection and Antigen-Specific IFN-γ Responses if IL-12p70 Is Available1

S. Khader, A. Cooper, N. Ghilardi, 2005, The Journal of Immunology.

Different Epitopes of the Macrophage Type Three Complement Receptor (CR3) Are Used to Bind Leishmania Promastigotes Harvested at Different Phases of Their Growth Cycle

J. Blackwell, T. Roach, A. Cooper, 1989 .

The cytolytic activity of natural killer cells is not involved in the restriction of Mycobacterium avium growth.

R. Appelberg, M. Flórido, A. Cooper, 2003, International immunology.

Cutting Edge: IFN-γ Regulates the Induction and Expansion of IL-17-Producing CD4 T Cells during Mycobacterial Infection1

J. Pedrosa, S. Khader, A. Cooper, 2006, The Journal of Immunology.

IL12Rβ1ΔTM Is a Secreted Product of il12rb1 That Promotes Control of Extrapulmonary Tuberculosis

Halli E. Miller, A. Cooper, R. Robinson, 2014, Infection and Immunity.

Acquired Immunity: Chronic Bacterial Infections

A. Cooper, R. Robinson, 2011 .

CD4 is required for the development of a protective granulomatous response to pulmonary tuberculosis.

I. Orme, B. Saunders, A. Cooper, 2002, Cellular immunology.

Lipoarabinomannan in Active and Passive Protection Against Tuberculosis

C. Sundling, A. Cooper, G. Källenius, 2019, Front. Immunol..

CD25-Targeted IL-2 Signals Promote Improved Outcomes of Influenza Infection and Boost Memory CD4 T Cell Formation

F. Alam, S. Sell, T. Strutt, 2020, The Journal of Immunology.

Immunological basis of the development of necrotic lesions following Mycobacterium avium infection

R. Appelberg, M. Flórido, A. Cooper, 2002, Immunology.

An anti-inflammatory role for gamma delta T lymphocytes in acquired immunity to Mycobacterium tuberculosis.

I. Orme, B. Bloom, A. Cooper, 1997, Journal of immunology.

Of mice and mycobacteria: lessons from a manipulatable model.

A. Cooper, J. Pearl, 2015 .

Expression of memory immunity in the lung following re-exposure to Mycobacterium tuberculosis.

I. Orme, J. Belisle, A. Cooper, 1997, Tubercle and lung disease : the official journal of the International Union against Tuberculosis and Lung Disease.

Transient Requirement of the PrrA-PrrB Two-Component System for Early Intracellular Multiplication of Mycobacterium tuberculosis

C. Locht, N. Mielcarek, B. Gicquel, 2002, Infection and Immunity.

Mycobacterium tuberculosis-driven processes in gene-disrupted mice

I. Orme, B. Saunders, A. Cooper, 1997 .

MURINE MODEL OF TUBERCULOSIS

Alan D. Roberts, I. Orme, J. Belisle, 2002 .

4 Specific Models: 4.1 Murine Model of Tuberculosis

Alan D. Roberts, I. Orme, J. Belisle, 1998 .

Effect of high intensity interval training and moderate intensity continuous training on lymphoid, myeloid and inflammatory cells in kidney transplant recipients.

N. Bishop, Alice C. Smith, A. Cooper, 2022, Exercise immunology review.

VALIDATE: Exploiting the synergy between complex intracellular pathogens to expedite vaccine research and development for tuberculosis, leishmaniasis, melioidosis and leprosy

P. Kaye, H. McShane, R. Reljic, 2018, F1000Research.

Activation of the Mitogen-Activated Protein Kinase Signaling Pathway Is Instrumental in Determining the Ability of Mycobacterium avium to Grow in Murine Macrophages

E. Chan, A. Cooper, H. Tse, 2001 .

Tc 17 , a Unique Subset of CD 8 T Cells That Can Protect against Lethal Influenza Challenge 1

Richard, T. Strutt, S. Swain, 2009 .

A novel nonclassic beta2-microglobulin-restricted mechanism influencing early lymphocyte accumulation and subsequent resistance to tuberculosis in the lung.

S. Ehlers, I. Orme, A. Cooper, 2000, American journal of respiratory cell and molecular biology.

BCG vaccination-induced long-lasting control of Mycobacterium tuberculosis correlates with the accumulation of a novel population of CD4⁺IL-17⁺TNF⁺IL-2⁺ T cells.

R. Appelberg, J. Pedrosa, M. Saraiva, 2015, Vaccine.

Balance between Protection and Pathogenic Response to Aerosol Challenge with Mycobacterium tuberculosis (Mtb) in Mice Vaccinated with TriFu64, a Fusion Consisting of Three Mtb Antigens

G. Mukamolova, A. Cooper, Sadaf Sulman, 2021, Vaccines.

Pathological role of interleukin 17 in mice subjected to repeated BCG vaccination after infection with Mycobacterium tuberculosis

J. Pedrosa, T. Randall, M. Saraiva, 2010, The Journal of experimental medicine.

A Limited Antigen-Specific Cellular Response Is Sufficient for the Early Control of Mycobacterium tuberculosis in the Lung but Is Insufficient for Long-Term Survival

S. Ehlers, I. Orme, J. Belisle, 2004, Infection and Immunity.

A Limited Antigen-Speciﬁc Cellular Response Is Sufﬁcient for the Early Control of Mycobacterium tuberculosis in the Lung but Is Insufﬁcient for Long-Term Survival

S. Ehlers, I. Orme, J. Belisle, 2004 .

Interleukin 27 R regulates CD 4 + T cell phenotype and impacts protective immunity during Mycobacterium tuberculosis infection

Rachel P. J. Lai, Xinchun Chen, D. Zak, 2015 .

Adequate Expression of Protective Immunity in the Absence of Granuloma Formation in Mycobacterium tuberculosis-Infected Mice with a Disruption in the Intracellular Adhesion Molecule 1 Gene

I. Orme, A. Cooper, Christine M. Johnson, 1998, Infection and Immunity.

Antigen-Specific IFN-Dispensable for Protection and Response during Tuberculosis but Is IL-12 p 70 and Is Essential for the IL-17 IL-23 Compensates for the Absence of Ghilardi

A. Cooper, N. Ghilardi, J. Pearl, 2005 .

T-cell responses to infected autologous monocytes in patients with cutaneous and mucocutaneous leishmaniasis.

C. Karp, P. Melby, A. Cooper, 1994, Clinical and diagnostic laboratory immunology.

IL‐23 and IL‐17 have a multi‐faceted largely negative role in fungal infection

A. Cooper, 2007, European journal of immunology.

Faculty Opinions recommendation of Distinct, specific IL-17- and IL-22-producing CD4+ T cell subsets contribute to the human anti-mycobacterial immune response.

A. Cooper, 2008 .

CD95 signaling is not required for the down regulation of cellular responses to systemic Mycobacterium tuberculosis infection.

I. Orme, A. Cooper, J. Pearl, 2000, Tubercle and lung disease : the official journal of the International Union against Tuberculosis and Lung Disease.

Enhanced serodiagnostic potential of a fusion molecule consisting of Rv1793, Rv2628 and a truncated Rv2608 of Mycobacterium tuberculosis

I. Khan, A. Cooper, A. Ambreen, 2021, PloS one.

Differential expression of an alternative splice variant of IL-12Rβ1 impacts early dissemination in the mouse and associates with disease outcome in both mouse and humans exposed to tuberculosis

Xinchun Chen, A. Singhania, A. O’Garra, 2018, bioRxiv.

Disseminated tuberculosis in interferon gamma gene-disrupted mice

I. Orme, A. Cooper, D. Russell, 1993, The Journal of experimental medicine.

Editorial: Mycobacterial Glycolipids—Role in Immunomodulation and Targets for Vaccine Development

J. Nigou, A. Cooper, G. Källenius, 2020, Frontiers in Immunology.

IL‐17 and anti‐bacterial immunity: Protection versus tissue damage

A. Cooper, 2009, European journal of immunology.

ESAT-6-specific CD4 T cell responses to aerosol Mycobacterium tuberculosis infection are initiated in the mediastinal lymph nodes

Alan D. Roberts, S. Wittmer, D. Woodland, 2008, Proceedings of the National Academy of Sciences.