B. Paolella

发表

Multiplexed single-cell profiling of post-perturbation transcriptional responses to define cancer vulnerabilities and therapeutic mechanism of action

James M. McFarland, A. Regev, T. Golub, 2019, bioRxiv.

Next-generation characterization of the Cancer Cell Line Encyclopedia

Joshua M. Korn, Jacob D. Jaffe, Ellen T. Gelfand, 2019, Nature.

Mitogenic and progenitor gene programmes in single pilocytic astrocytoma cells

Mariella G. Filbin, Zachary T Herbert, Robert T. Jones, 2019, Nature Communications.

Loss of heterozygosity of essential genes represents a widespread class of potential cancer vulnerabilities

Ashton C. Berger, R. Beroukhim, A. Cherniack, 2020, Nature Communications.

Loss of heterozygosity of essential genes represents a widespread class of potential cancer vulnerabilities

Ashton C. Berger, R. Beroukhim, A. Cherniack, 2019, bioRxiv.

Multiplexed single-cell transcriptional response profiling to define cancer vulnerabilities and therapeutic mechanism of action

James M. McFarland, A. Regev, T. Golub, 2020, Nature Communications.

Phosphate dysregulation via the XPR1:KIDINS220 protein complex is a therapeutic vulnerability in ovarian cancer

Joshua M. Dempster, James M. McFarland, John G Doench, 2020, Nature Cancer.

Expression profiles of 151 pediatric low-grade gliomas reveal molecular differences associated with location and histological subtype.

T. Golub, R. Beroukhim, P. Wen, 2015, Neuro-oncology.

Copy-number and gene dependency analysis reveals partial copy loss of wild-type SF3B1 as a novel cancer vulnerability

W. Hahn, G. Wei, R. Beroukhim, 2017, eLife.

Synthetic Lethal Interaction between the ESCRT Paralog Enzymes VPS4A and VPS4B in Cancers Harboring Loss of Chromosome 18q or 16q

T. Golub, W. Hahn, D. Root, 2020, Cell reports.

Selective modulation of a pan-essential protein as a therapeutic strategy in cancer.

Joshua M. Dempster, T. Golub, V. Hovestadt, 2021, Cancer discovery.

Systematic profiling of conditional degron tag technologies for target validation studies

T. Golub, W. Sellers, F. Vazquez, 2022, Nature Communications.

BET Bromodomain Inhibition of MYC-Amplified Medulloblastoma

R. Beroukhim, S. Schumacher, J. Qi, 2013, Clinical Cancer Research.

Partial gene suppression improves identification of cancer vulnerabilities when CRISPR-Cas9 knockout is pan-lethal

Joshua M. Dempster, James M. McFarland, T. Golub, 2022, bioRxiv.

A First-Generation Pediatric Cancer Dependency Map

Joshua M. Dempster, James M. McFarland, Thomas P. Howard, 2021, Nature Genetics.

Next-generation characterization of the Cancer Cell Line Encyclopedia

Jacob D. Jaffe, Ellen T. Gelfand, James M. McFarland, 2019, Nature.

MYB-QKI rearrangements in Angiocentric Glioma drive tumorigenicity through a tripartite mechanism

Liliana Goumnerova, Caterina Giannini, Rameen Beroukhim, 2016, Nature Genetics.

Targeting cancer gene dependencies with anthrax-mediated delivery of peptide nucleic acids.

R. Beroukhim, B. Paolella, John P. Busanovich, 2020, ACS chemical biology.

Neuronal differentiation and cell-cycle programs mediate response to BET-bromodomain inhibition in MYC-driven medulloblastoma

Emily J. Girard, Jacob D. Jaffe, W. Hahn, 2019, Nature Communications.

Paralog knockout profiling identifies DUSP4 and DUSP6 as a digenic dependence in MAPK pathway-driven cancers

John G Doench, G. Getz, W. Sellers, 2021, Nature Genetics.

Cancer Therapy : Preclinical BET Bromodomain Inhibition of MYC-Ampli fi ed Medulloblastoma

R. Beroukhim, S. Schumacher, J. Qi, 2014 .

Abstract 3003: Loss of heterozygosity of essential genes represents a novel class of cancer vulnerabilities

Ashton C. Berger, R. Beroukhim, A. Cherniack, 2018, Molecular and Cellular Biology / Genetics.

Id2 mediates oligodendrocyte precursor cell maturation arrest and is tumorigenic in a PDGF-rich microenvironment.

M. Israel, M. Havrda, B. Paolella, 2014, Cancer research.

Id2 Is Required for Specification of Dopaminergic Neurons during Adult Olfactory Neurogenesis

M. Israel, H. Yeh, B. Harris, 2008, The Journal of Neuroscience.

Phosphorylation Regulates Id2 Degradation and Mediates the Proliferation of Neural Precursor Cells

M. Israel, S. Gerber, A. Kettenbach, 2016, Stem cells.

Neuronal differentiation and cell-cycle programs mediate response to BET-bromodomain inhibition in MYC-driven medulloblastoma

Emily J. Girard, Jacob D. Jaffe, W. Hahn, 2019, Nature communications.

Behavioral abnormalities and Parkinson’s-like histological changes resulting from Id2 inactivation in mice

M. Havrda, B. Paolella, K. Holroyd, 2012, Disease Models & Mechanisms.

Gliomas "Dope Up" for Growth.

C. Stiles, B. Paolella, 2016, Cancer cell.

p53 Directly Represses Id2 to Inhibit the Proliferation of Neural Progenitor Cells

M. Israel, M. Havrda, B. Paolella, 2011, Stem cells.

Gliomas "Dope Up" for Growth.

C. Stiles, B. Paolella, 2016, Cancer cell.

Neuronal differentiation and cell-cycle programs mediate response to BET-bromodomain inhibition in MYC-driven medulloblastoma

Emily J. Girard, Jacob D. Jaffe, W. Hahn, 2019, Nature Communications.

Abstract NG01: Synthetic lethal interaction between the ESCRT paralog enzymes VPS4A and VPS4B in cancers harboring loss of chromosome 18q or 16q

T. Golub, W. Hahn, D. Root, 2021, Molecular and Cellular Biology/Genetics.

Synthetic Lethal Interaction between the ESCRT Paralog Enzymes VPS4A and VPS4B in Cancers Harboring Loss of Chromosome 18q or 16q

T. Golub, W. Hahn, D. Root, 2021, Cell reports.